Man

Sergio Alejandro Lavandero Gonzalez

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Líneas de Investigación


Regulación de la concentración de calcio intracelular en células excitables; Mecanismos moleculares de cardioprotección; Regulación Redox de proteinas; Precondicionamiento Cardiaco; Hipertrofia cardiaca; Isquemia/Reperfusión cardiaca; Degradación de proteínas; Transduccion de Señales; Metabolismo; Insulina, Muerte celular: Apoptosis, Autofagia; Enfermedades Cardiovasculares

Educación

  •  Bioquimica, UNIVERSIDAD DE CHILE. Chile, 1993

Experiencia Académica

  •   Profesor Titular Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Quimicas y Farmaceuticas

    Santiago, Chile

    Enero 1985 - A la fecha

  •   Profesor Titular Part Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    Enero 2002 - A la fecha

  •   Adjunct Professor Other

    UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER AT DALLAS

    Dallas, Estados Unidos

    Enero 2014 - A la fecha


Tipos de Producción
 

Article (155)

Atrial Function Assessed by Speckle Tracking Echocardiography Is a Good Predictor of Postoperative Atrial Fibrillation in Elderly Patients
BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism
Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism
FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation
Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression
Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival
Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024
TonEBP suppresses IL-10-mediated immunomodulation
Glutathione Depletion Induces Spermatogonial Cell Autophagy
Hyperandrogenism Decreases GRP78 Protein Level and Glucose Uptake in Human Endometrial Stromal Cells
Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases
Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability
Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition
Unsaturated fatty acids induce non-canonical autophagy
4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast
A novel dihydropyridine with 3-aryl meta-hydroxyl substitution blocks L-type calcium channels in rat cardiomyocytes
Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes
Ca2+ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells
Effects of Trimetazidine in Nonischemic Heart Failure: A Randomized Study
Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy
Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NF kappa B-Opa-1 Signaling Pathway
Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake
Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics
Role of Heterotrimeric G Protein and Calcium in Cardiomyocyte Hypertrophy Induced by IGF-1
Serotonin (5-HT) Regulates Neurite Outgrowth Through 5-HT1A and 5-HT7 Receptors in Cultured Hippocampal Neurons
Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death
Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy
Cell Death and Survival Through the Endoplasmic Reticulum-Mitochondrial Axis
Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3K gamma-Akt-AS160 in Skeletal Muscle Cells
Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells
Herp depletion protects from protein aggregation by up-regulating autophagy
Local Control of Nuclear Calcium Signaling in Cardiac Myocytes by Perinuclear Microdomains of Sarcolemmal Insulin-Like Growth Factor 1 Receptors
Testosterone Increases GLUT4-Dependent Glucose Uptake in Cardiomyocytes
TGF-beta 1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways
A BAX/BAK and Cyclophilin D-Independent Intrinsic Apoptosis Pathway
Apoptosis, necrosis and autophagy are influenced by metabolic energy sources in cultured rat spermatocytes
Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol
Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart
Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics
Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy
Impaired cardiac autophagy in patients developing postoperative atrial fibrillation
Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice
NFAT5 Is Activated by Hypoxia: Role in Ischemia and Reperfusion in the Rat Kidney
Protein Carbonylation and Adipocyte Mitochondrial Function
Relationship between mechanical and metabolic dyssynchrony with left bundle branch block: Evaluation by 18-fluorodeoxyglucose positron emission tomography in patients with non-ischemic heart failure
Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability
Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress
Inhibition of autophagy by TAB2 and TAB3
Left Atrial Dysfunction Is a Predictor of Postcoronary Artery Bypass Atrial Fibrillation: Association of Left Atrial Strain and Strain Rate Assessed by Speckle Tracking
Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure
Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension
Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts
Systemic Oxidative Stress and Endothelial Dysfunction is Associated With an Attenuated Acute Vascular Response to Inhaled Prostanoid in Pulmonary Artery Hypertension Patients
Systemic vascular cell adhesion molecule-1 predicts the occurrence of post-operative atrial fibrillation
The complex interplay between mitochondrial dynamics and cardiac metabolism
The role of uric acid in heart failure
Xanthine-oxidase inhibitors and statins in chronic heart failure: Effects on vascular and functional parameters
An inositol 1,4,5-triphosphate (IP 3)-IP 3 receptor pathway is required for insulin-stimulated glucose transporter 4 translocation and glucose uptake in cardiomyocytes
An Inositol 1,4,5-Triphosphate (IP3)-IP3 Receptor Pathway Is Required for Insulin-Stimulated Glucose Transporter 4 Translocation and Glucose Uptake in Cardiomyocytes
Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro
Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion
Contraction-related stimuli regulate GLUT4 traffic in C 2C 12-GLUT4myc skeletal muscle cells
Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells
Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes
Heart energy metabolism and its role in the treatment of heart failure Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca
Increased levels of oxidative stress, subclinical inflammation, and myocardial fibrosis markers in primary aldosteronism patients
Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide
Mitochondria fine-tune the slow Ca 2+ transients induced by electrical stimulation of skeletal myotubes
Mitochondria fine-tune the slow Ca2+ transients induced by electrical stimulation of skeletal myotubes
Mitochondrial Fission and Autophagy in the Normal and Diseased Heart
Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica
Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress
The IKK complex contributes to the induction of autophagy
(TTA)n Polymorphism in 3-Hydroxy-3-Methylglutaryl-Coenzyme A and Response to Atorvastatin in Coronary Artery Disease Patients
Differential Participation of Angiotensin II Type 1 and 2 Receptors in the Regulation of Cardiac Cell Death Triggered by Angiotensin II
Ex vivo method to visualize and quantify vascular networks in native and tissue engineered skin
Gln 27?Glu? 2-adrenergic receptor polymorphism in heart failure patients: Differential clinical and oxidative response to carvedilol
Gln(27)-> Glu beta(2)-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and Oxidative Response to Carvedilol
Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with ?v?3 integrin that activates PKC? and RhoA
Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alpha v beta 3 integrin that activates PKC alpha and RhoA
Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species
Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling
The use of glandular-derived stem cells to improve vascularization in scaffold-mediated dermal regeneration
Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity
Use of Human Mesenchymal Cells to Improve Vascularization in a Mouse Model for Scaffold-Based Dermal Regeneration
Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism
Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes
Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor
Pleiotropic effects of atorvastatin in heart failure: Role in oxidative stress, inflammation, endothelial function, and exercise capacity
Senescence, apoptosis or autophagy?
Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure
Subclinical endothelial inflammation markers in a family with type I familial hyperaldosteronism caused by a de novo mutation
Mitochondrial control of cell death induced by hyperosmotic stress
Regulation of autophagy by the inositol trisphosphate receptor
The inositol trisphosphate receptor in the control of autophagy
Tumor necrosis factor-? activates nuclear factor-?B but does not regulate progesterone production in cultured human granulosa luteal cells
Tumor necrosis factor-alpha activates nuclear factor-kappa B but does not regulate progesterone production in cultured human granulosa luteal cells
Effect of hypertension on angiotensin-(1-7) levels in rats with different angiotensin-I converting enzyme polymorphism
Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat
Hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death
Hyperosmotic stress activates p65/RelB NF?B in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death
Hyperosmotic stress-dependent NF kappa B activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes
Hyperosmotic stress-dependent NF?B activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes
Membrane electrical activity elicits inositol 1,4,5-trisphosphate-dependent slow Ca2+ signals through a G beta gamma/phosphatidylinositol 3-kinase gamma pathway in skeletal myotubes
Membrane electrical activity elicits inositol 1,4,5-trisphosphate-dependent slow Ca2+ signals through a G??/phosphatidylinositol 3-kinase ? pathway in skeletal myotubes
Reactive oxygen species inhibit hyposmotic stress-dependent volume regulation in cultured rat cardiomyocytes
Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes
Effects of carvedilol on oxidative stress and chronotropic response to exercise in patients with chronic heart failure
Effects of Carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure
Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels
IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB
Increased aortic NADPH oxidase activity in rats with genetically high angiotensin-converting enzyme levels
Oxidative stress in pericardial fluid and plasma and its association with ventricular function
Perindopril regulates ?-agonist-induced cardiac apoptosis
Perindopril regulates beta-agonist-induced cardiac apoptosis
Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress in patients with chronic heart failure
Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes
Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humans
Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats
Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis - Differential effects of sorbitol and mannitol
IGF-1 modulation of rat cardiac fibroblast behavior and gene expression is age-dependent
Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-1-converting enzyme deletion/deletion genotype
Relation between oxidative stress, catecholamines, and impaired chronotropic response to exercise in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model
Angiotensin I-converting enzyme insertion/deletion polymorphism and adrenergic response to exercise in hypertensive patients
Effects of early decrease in oxidative stress after medical therapy in patients with class IV congestive heart failure
Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial hypertrophy and fibrosis
Oxidative stress after reperfusion with primary coronary angioplasty: Lack of effect of glucose-insulin-potassium infusion
Persistence of oxidative stress after heart tranplantation: A comparative study of patients with heart transplant versus chronic stable heart failure
Persistence of oxidative stress after heart transplantation: A comparative study of patients with heart transplant versus chronic stable heart failure
A rapid and strong apoptotic process is triggered by hyperosmotic stress in cultured rat cardiac myocytes
Angiotensin I-converting enzyme modulates neutral endopeptidase activity in the rat
Early prevention of experimental left ventricular hypertrophy in experimental hypertension and angiotensin II levels
Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth factor-1 on cultured cardiac myocytes
IGF-1 regulates apoptosis of cardiac myocyte induced by osmotic-stress
Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat
Prevalence of the angiotensin I converting enzyme insertion/deletion polymorphism, plasma angiotensin converting enzyme activity, and left ventricular mass in a normotensive Chilean population
In vivo and in vitro evidence of basic fibroblast growth factor action in mouse mammary gland development
Selective increase in cardiac IGF-1 in a rat model of ventricular hypertrophy
IGF-1 activates polyphosphoinositide hydrolysis, protein kinase C isoforms and ERK pathway in cultured neonatal rat cardiac myocytes
Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes
Omeprazole, a specific gastric secretion inhibitor on oxynticopeptic cells, reduces gizzard erosion in broiler chicks fed with toxic fish meals
Cyclic AMP dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction
Synthesis and pharmacological effects of 3-methyl tyrphostin (2-cyano- 3-[4-hydroxyphenyl]-2-butenethioamide): A new protein tyrosine kinase inhibitor

Abstract (31)

Glutathione depletion in spermatogonia-type germ cells: Autophagy and Ago2 function
FoxO1 switches energy metabolism and stimulates mitochondrial fission in myocardial insulin resistance.
Angiotensin-(1-9) Decreases Hypertension and Vascular Damage by Inhibiting Rhoa/rock Activity in Doca Hypertensive Rats
FoxO1 Ablation Rescues Metabolic Stress-induced Cardiac Remodeling
Germ cell autophagy: adaptive response to glutathione deficiency
Herp protects Hela cells from oxidative stress-induced cell death
Polycystin 2 is Required for Stress-induced Activation of Autophagy in Heart
Polycystin-1 Regulates Cardiac Hypertrophy via the L-type Calcium Channel
Effect of proinflammatory cytokines on mitochondrial function in 3T3-L1 adipocytes
NAD(P)H oxidase-dpendent H2O2 production and RyR-IP3R activation are required for insulin induced GLUT4 translocation and glucose uptake in skeletal muscle cells
New insights into insulin action in the heart
Persistent Activation of FoxO Contributes to Insulin Resistance and Diabetic Cardiomyopathy
MITOCHONDRIA MODULATE INTRACELLULAR CALCIUM SIGNALS THAT CONTROL ATP TRANSIENTS INDUCED BY ELECTRICAL STIMULATION OF SKELETAL MYOTUBES
Use of pancreas-derived stem cells to improve vascularization in skin tissue engineering
Effects of atorvastatin therapy in heart failure: Oxidative stress, inflammation, endothelial dysfunction and exercise capacity
Inflammation and endothelial dysfunction in patients with chronic heart failure
Mitochondrial Ca2+ transients upon electrical stimulation of skeletal myotubes
Up-regulation of ACE2 by enalapril is associated to lower cardiac remodeling in myocardial infarcted rat
Early expression of vascular transforming growth factor beta 1 (TGF beta 1) in DOCA-salt rats
IGF-1 prevents NF kappa B activation but not reactive oxygen species generation by hyperosmotic stress in apoptotic cultured cardiac myocytes
Influence of angiotensin-I converting enzyme polymorphism in the isoproterenol-induced extracellular matrix proteins deposition by cardiac fibroblasts.
Angiotensin converting enzyme polymorphism determines differential acumulation of cardiac extracelular matrix protein induced by isoproterenol in the rat
beta 1 and beta 2-adrenergic receptor gene polymorphisms are not associated with heart failure
Hyperosmotic stress induces oxidative stress and NF kappa B activation in cultured cardiac myocytes
Ethnic differences in beta 2 adrenergic receptor polymorphisms distribution
IGF-1 modulates cardiac fibroblast migration and adhesion through the expression and synthesis of alpha 1, beta 1-integrin and collagen
Angiotensin I-converting enzyme gene polymorphism modulates chronic hypertensive response in the rat Goldblatt model
IGF-1 regulates integrin and collagen expression and cell-ECM interactions on cultured rat cardiac fibroblasts
PI3-K/PKB pathway on the antiapoptotic response of IGF-1 in cardiac myocytes
Tissue neutral endopeptidase activity is inversely related to angiotensin I-converting enzyme expression in the rat
Gene transcription associated to cardiomyocyte hypertrophy is differentially regulated by IGF-1

Generic (23)

Insulin Induces both H2O2 Production and IP3-Dependent Mitochondria Ca2+ Uptake. H2O2 Oxidizes RyR to Elicit Ca2+ Release and GLUT4 Translocation in Skeletal Muscle Cells
ICDS 2011 meeting 'Signaling in cell death survival, proliferation and degeneration'
Mitochondria, Myocardial Remodeling, and Cardiovascular Disease
Anabolic Androgenic Steroids and Intracellular Calcium Signaling: A Mini Review on Mechanisms and Physiological Implications
Angiotensin-(1-9) Prevents Cardiomyocyte Hypertrophy Through Calcium Influx Dependent Pathway
Angiotensin-(1-9) Prevents the Cardiovascular Pathological Remodeling Induced by Angiotensin II In Vivo
The role of uric acid in heart failure Ácido úrico: Una molécula con acciones paradójicas en la insuficiencia cardiaca
Evidence of impaired cardiac autophagic flux in patients developing post-operative atrial fibrillation
Heart energy metabolism and its role in the treatment of heart failure
Insulin-Mediated GLUT4 Translocation Requires Intracellular and Extracellular Calcium and is Impaired by Short-Term High Fat Feeding
Increased Oxidative Stress Correlates With Pulmonary Vascular Response to Vasodilators in Pulmonary Artery Hypertension Patients
Angiotensin II triggers apoptosis in cardiac fibroblast but not in myofibroblast overexpressing the type 1 receptor
Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives
Activity of metalloproteinase-9 is related to oxidative stress in the acute coronary syndrome
Carvedilol corrects interventricular and interventricular dyssynchrony in chronic heart failure.
Apoptosis induced by hyperosmotic stress
Decrease in oxidative stress is not related to left ventricular function improvement in patients with chronic heart failure treated with carvedilol
Gene expression of profibrotic factors in isoproterenol-treated Brown-Norway and Lewis rats
The Arg389Arg adrenergic receptor variant interacts with the Arg16Arg and Gly27Gly beta 2 adrenergic receptor variants decreasing the risk for chronic heart failure
beta(2)-adrenergic receptor polymorphisms are not associated with heart failure
Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in normotensive and hypertensive subjects
Myocardial angiotensin II generation and the angiotensin I - converting enzyme gene polymorphism in the rat
Early decrease in oxidative stress in patients with class IV heart failure after successfull medical therapy

Review (22)

Mitochondrial dynamics, mitophagy and cardiovascular disease
New molecular insights of insulin in diabetic cardiomyopathy
ACE2 and vasoactive peptides: Novel players in cardiovascular/renal remodeling and hypertension
Autophagy in cardiovascular biology
Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy
ER-to-mitochondria miscommunication and metabolic diseases
Molecular Mechanisms of Autophagy in the Cardiovascular System
Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9)
Calcium signaling in insulin action on striated muscle
Oxidative Stress and Autophagy in Cardiovascular Homeostasis
Tumor Suppression and Promotion by Autophagy
Cardiovascular autophagy Concepts, controversies, and perspectives
Diabetic cardiomyopathy and metabolic remodeling of the heart
Endoplasmic Reticulum and the Unfolded Protein Response: Dynamics and Metabolic Integration
Regulation of cardiac autophagy by insulin-like growth factor 1
Guidelines for the use and interpretation of assays for monitoring autophagy
Autophagy as a therapeutic target in cardiovascular disease
Cardiomyocyte death: mechanisms and translational implications
Mitochondrial Dynamics: a Potential New Therapeutic Target for Heart Failure
Tuning flux: autophagy as a target of heart disease therapy
Ca2+, autophagy and protein degradation: Thrown off balance in neurodegenerative disease
Rho/Rho kinase signal transduction pathway in cardiovascular disease and cardiovascular remodeling

Editorial Material (5)

Parkin Gone Wild Unbridled Ubiquitination
Regulation of Cardiovascular Metabolism by Hormones and Growth Factors
Signaling in Cell Death, Survival, Proliferation and Degeneration
IKK connects autophagy to major stress pathways
Mechanisms of cell death: molecular insights and therapeutic perspectives

Letter (3)

Dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure Reply
Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome
Uric acid, xanthine oxidase and heart failure: Unresolved issues

Book Whole (2)

Autophagy in cardiac physiology and disease
Regulation of autophagy by insulin/IGF-1 signaling pathways

Errata (1)

Mitochondrial control of cell death induced by hyperosmotic stress (vol 12, pg 3, 2007)

Nil Class (0)

248
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

94
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

33
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

33
Jorge Jalil

FULL PROFESSOR

ENFS CARDIOVASCULARES

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE MEDICINA

Santiago, Chile

31
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

28
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

27
Ramon Corbalan

Director

Division of Cardiovascular Diseases

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

25
Rodrigo Troncoso

Assistant professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

21
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

20
Hugo Verdejo

Profesor Asistente

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

19
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

15
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

11
Rosemarie Mellado

Jefe de carrera / Académica

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

10
Andrea del Campo

Posdoctorado

Laboratorio de FIsiología del músculo

Universidad de Chile

Santiago, Chile

9
Samuel Cordova

ESCUELA DE MEDICINA, PONTIFICA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

9
Roberto Bravo

Investigador Postdoctoral

Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile

Santiago, Chile

7
Pablo Aránguiz

Postdoctorado

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

7
Gina Sánchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

6
Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

5
Eugenia Morselli

Assistant professor

Pontificia Universidad Católica

Santiago, Chile

5
Roberto Ebensperger

Associate Professor

Pharmacy

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

4
Manuel Estrada

/Associate Professor / PI

Physiology and Biophysics

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS (ICBM), PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

4
Claudio Olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Jose Egana

Profesor asistente

Instituto de Ingeniería Biológica y Médica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Rodrigo Valenzuela

Profesor Titular

Universidad Católica Silva Henríquez

Santiago, Chile

3
Carolina Nazzal

jefa

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

3
Cesar Osorio

Associate Professor

Kinesiología

Universidad Metropolitana de Ciencias de la Educación

Santiago, Chile

3
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

3
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Juan Carlos Quintana

Médico nuclear

Radiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Eugenia Morselli

Profesor Asistente de Planta Ordinaria

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

3
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Cristian Carvajal

Assistant Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Lorena Aguilar

Assistant Professor

Pathology

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

2
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

2
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

2
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

2
Pablo Irarrazaval

Professor

Electrical Engineering

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Andrés Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

2
Dagoberto Soto

Investigador

Universidad Católica de Chile

santiago, Chile

2
Juan Villena

ASSOCIATE PROFESSOR

BIOMEDICAL SICIENCES

FACULTA DE MEDICINA. UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

2
Carlos Vio

Director General de Investigación, Postgrado y Centros

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
MANUEL VARAS

Assistant Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

2
Berta Espinosa

Assistant Professor

Tecnología Médica

Universidad de Chile

Santiago, Chile

1
Claudia Bambs

Profesor asistente

Salud Publica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Felipe Court

Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Julio Tapia

Associate Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Gerald Zapata

DEPARTAMENTO DE QUÍMICA INORGÁNICA Y ANALÍTICA FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS UNIVERSIDAD DE CHILE

Santiago, Chile

1
Maite Castro

Professor

Faculty of Sciences

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Julio Cardenas

Assistant Professor

Anatomy and Developmental Biology

University of Chile

Santiago, Chile

1
Ismael Maldonado

Asistente de Investigación

Inmunología

Universidad de Chile

Santiago, Chile

1
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Javier Morales Montecinos

Profesor Asistente

Departamento de Ciencias y Tecnología Farmacéuticas

Universidad de Chile

Santiago, Chile

1
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

SAntiago, Chile

1
Andrea Calixto

Assistant Professor

Biological Sciences

Universidad Mayor

Santiago, Chile

1
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Francisco Nualart

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
SANDRA CORTES

ASSISTANT PROFESSOR

PUBLIC HEALTH

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Juan Santibáñez

Professor of Research

Molecular Oncology

Institute for Medical Research

Belgrade, Serbia

1
Sergio González

FACULTAD DE MEDICINA. PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Ricardo Moreno

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

1
Juan Reyes

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

1
Claudia Foerster

Profesora Asistente

Instituto de Ciencias Agronómicas y Veterinarias

Universidad de O'Higgins

Rancagua, Chile

1
Rolando de la Cruz

Associate Professor

Faculty of Engineering and Sciences

Universidad Adolfo Ibáñez

Peñalolén, Santiago, Chile

1
Galia Ramirez

PROFESOR ASISTENTE

DEPARTAMENTO DE MEDICINA PREVENTIVA ANIMAL

UNIVERSIDAD DE CHILE - FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

1
Carolina Ribeiro

Assistant Professor

Immunology Program

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

1
Jenny Blamey

Director

Research and Development

FUNDACIÓN CIENTÍFICA Y CULTURAL BIOCIENCIA

Santiago, Chile

1
Monica Acevedo

Associate Professor

Division of Cardiovascular Diseases

P. UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Carlos Puebla

Profesor Asistente

Universidad Autónoma de Chile

Santiago, Chile

1
Luis Sobrevia

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Roxana Pincheira

Profesor Asociado

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

1
Ariel Castro

Associate Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

1
Tatiana Adasme

Associate Professor, CIBQA Researcher

Centro Integrativo de Biología y Química Aplicada (CIBQA)

Universidad Bernardo OHiggins

Santiago, Chile

1
Carmen Romero

Jefe Laboratorio Endocrinología y Biología Reproductiva

Obstetricia y Ginecología

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile

1
Maria Vega

Academico Profesora Titular

Obstetricia y Ginecologia Campus Norte

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

1
Maria Lisbona

Postdoctorado

Biología

Universidad de Chile

Santiago, Chile

1
Maria Molina

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
lorena mosso

profesor asociado

endocrinologia

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Ivonne Olmedo

Assistant Profesor

Programa de Fisiopatología

Universidad de Chile

Santiago, Chile

1
Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Lorena Lobos-Gonzalez

Principal Investigator-Prosesor Asociado

Facultad de Medicina - Clinica Alemana

Universidad Del Desarrollo

santiago, Chile

1
Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

1
Steffen Hartel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Alvaro Passi

Coordinador técnico de proyectos de investigación

Salud Pública

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ramiro Zepeda

Academico

Farmacologia y neurociencia

universidad de Chile

santiago, Chile

1
Rodrigo Herrera Molina

Group Leader (staff member)

Neurochemistry and Molecular Biology

Leibniz Institute for Neurobiology

Magdeburg, Alemania

1
Laura Andrea Huidobro

Académico

Ciencias Preclínicas

Universidad Católica del Maule

Talca, Chile