Man

Cecilia M. Hidalgo Tapia

Professor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Functional role of calcium release through Ryanodine Receptors (RyR)/calcium channels of hippocampal neurons. Characterization of how cellular redox state regulates RyR activity, synaptic plasticity and memory.

Educación

  •  Doctora en Ciencias, Mención Biología, Universidad de Chile. Chile, 1969
  •  Bioquímica, Universidad de Chile. Chile, 1965

Experiencia Académica

  •   Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    Enero 1965 - A la fecha

  •   Senior Investigator Part Time

    CENTRO DE ESTUDIOS CIENTIFICOS DE SANTIAGO

    Santiago, Chile

    Enero 1984 - Enero 2002

  •   Visiting Fellow Full Time

    NATIONAL INSTITUTE OF HEALTH

    Bethesda, MD, Estados Unidos

    Enero 1969 - Enero 1972

  •   ASSOCIATE Part Time

    HARVARD UNIVERSITY

    BOSTON, Estados Unidos

    Enero 1979 - Enero 1986

  •   STAFF SCIENTIST Full Time

    BOSTON BIOMEDICAL RESEARCH INSTITUTE

    BOSTON, Estados Unidos

    Enero 1974 - Enero 1986

Formación de Capital Humano


Tutor, PhD thesis Rodrigo Torres, Universidad de Chile

Tutor, PhD thesis J Alex Córdova, Universidad de Chile

Tutor, PhD thesis Ismael Valdés, Universidad de Chile

Tutor, PhD thesis, Jamileth More, Universidad de Chile

Co-Tutor, PhD thesis Alejandra Arias, Universidad de Valparaiso


Premios y Distinciones

  •   National Prize in Natural Sciences

    GOBIERNO DE CHILE

    Chile, 2006

    This prize is awarded every other year to a scientist with a distinguished carrer in natural sciences. I was the first woman to recieve this award


Tipos de Producción
 

Article (92)

Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release; both impinge on GLUT4 translocation.
Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates nnitochondrial Ca2+ uptake in primary hippocampal neurons
Redox-sensitive stimulation of type-1 ryanodine receptors by the scorpion toxin maurocalcine
The Antioxidant N-Acetylcysteine Prevents the Mitochondrial Fragmentation Induced by Soluble Amyloid-beta Peptide Oligomers
Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF
High-Frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-Mediated Ca2+ Release and Generates Hydrogen Peroxide, Which Jointly Stimulate NF-kappa B Activity
Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation
Iron Mediates N-Methyl-D-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity
Modulation of cardiac ryanodine receptor activity by ROS and RNS
Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion
Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training
Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide
Mitochondria fine-tune the slow Ca2+ transients induced by electrical stimulation of skeletal myotubes
Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress
Hypoxia stimulates via separate pathways ERK phosphorylation and NF-kappa B activation in skeletal muscle cells in primary culture
NADPH Oxidase and Hydrogen Peroxide Mediate Insulin-induced Calcium Increase in Skeletal Muscle Cells
The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible robe in cardioprotection
Ischemia enhances activation by Ca2+ and redox modification of ryanodine receptor channels from rat brain cortex
Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons
Calcium, iron and neuronal function
Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex
A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S-glutathionylation
Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
Fast kinetics of calcium dissociation from calsequestrin
Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1
Myotube depolarization generates reactive oxygen species through NAD(P)H oxidase; ROS-elicited Ca2+ stimulates ERK, CREB, early genes
Cross talk between Ca2+ and redox signalling cascades in muscle and neurons through the combined activation of ryanodine receptors/Ca2+ release channels
Effects of S-glutathionylation and S-nitrosylation on calmodulin binding to triads and FKBP12 binding to type 1 calcium release channels
Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle
Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells
Kinetic studies of calcium-induced calcium release in cardiac sarcoplasmic reticulum vesicles
S-glutathionylation decreases Mg2+ inhibition and S-nitrosylation enhances Ca2+ activation of RyR1 channels
Annexin VI is attached to transverse-tubule membranes in isolated skeletal muscle triads
Redox regulation of calcium release in skeletal and cardiac muscle
Sodium transport in triads isolated from rabbit skeletal muscle
SH Oxidation Stimulates Calcium Release Channels (Ryanodine Receptors) From Excitable Cells
Sodium/calcium exchange in amphibian skeletal muscle fibers and isolated transverse tubules
Sulfhydryl oxidation overrides Mg2+ inhibition of calcium-induced calcium release in skeletal muscle triads
ATP stimulation of Na +/Ca 2+ exchange in cardiac sarcolemmal vesicles
Cyclic ADP-ribose activates caffeine-sensitive calcium channels from sea urchin egg microsomes
Ca2+- and pH-dependent Halothane Stimulation of Calcium Release in Sarcoplasmic Reticulum from Frog Muscle.
Calcium dependence of ryanodine-sensitive calcium channels from brain cortex endoplasmic reticulum
Luminal pH regulates calcium release kinetics in sarcoplasmic reticulum vesicles
Protons induce calsequestrin conformational changes
Protons Induce Calsequestrin Conformational Changes. : 2130-2137
Luminal Calcium Regulates Calcium Release in Triads Isolated from Frog and Rabbit Skeletal Muscle.
Luminal Calcium Regulation of Calcium Release from Sarcoplasmic Reticulum.
Phospholipase C Activity in Membranes and a Soluble Fraction Isolated from Frog Skeletal Muscle.
Triads and Transverse Tubules Isolated from Skeletal Muscle Contain High Levels of Inositol 1,4,5-Trisphosphate. 268, 1511-1517
Inositol 1, 4, 5-Trisphosphatase Activity in Membranes Isolated from Amphibian Skeletal Muscle.
Sodium/Calcium Exchange in Transverse Tubule Vesicles Isolated from Amphibian Skeletal Muscle.
Sodium-Calcium Exchange in Transverse Tubule Vesicles Isolated from Frog Skeletal Muscle.
Activation of Calcium Channels in Sarcoplasmic Reticulum from Frog Muscle by Nanomolar Concentrations of Ryanodine.
Inositol Trisphosphate and Excitation-Contraction Coupling in Skeletal Muscle.
Calcium Modulation of Phosphoinositide Kinases in Transverse Tubule Vesicles from Frog Skeletal Muscle.
Inositol (1,4,5)-Trisphosphate Activates a Calcium Channel in Isolated Sarcoplasmic Reticulum Membranes.
Lipid Composition of Purified Transverse Tubule Membranes Isolated from Amphibian Skeletal Muscle.
Phosphorylation of Phosphatidylinositol by Transverse Tubule Vesicles and its Possible Role in Excitation-Contraction Coupling.
Transverse Tubules from Frog Skeletal Muscle. Purification and Properties of Vesicles Sealed with the Inside-Out Orientation.
Calcium Transport in Transverse Tubules Isolated from Rabbit Skeletal Muscle. Biochem
Ion Pathways in Transverse Tubules. Quantification of Receptors in Membranes Isolated from Frog and Rabbit Skeletal Muscle.
Characterization of the Ca2+-or Mg2+-ATPase of Transverse Tubule Membranes Isolated from Rabbit Skeletal Muscle.
Lipid-Protein Interactions in Sarcoplasmic Reticulum are not Perturbed by Ionophore A23187.
Rotational Dynamics of Protein and Boundary Lipid in Sarcoplasmic Reticulum Membranes.
Immunological and Biochemical Properties of Transverse Tubule Membranes Isolated from Rabbit Skeletal Muscle.
Highly Purified Sarcoplasmic Reticulum Vesicles are Devoid of a Ca2+-independent (‘Basal’) ATPase Activity.
Heterogeneity of SH Groups in Sarcoplasmic Reticulum.
Disposition of Proteins and Aminophospholipids in the Sarcoplasmic Reticulum Membrane.
Induction and General Properties of ß-Galactosidase and ß-Galactoside Permease in Pseudomonas BAL-31.
Stimulation of ß-Galactoside Transport in Pseudomonas BAL-31 by Infection with Bacteriophage PM2.
Sarcoplasmic Reticulum from Barnacle Muscle: Composition and Calcium Uptake Properties.
Methylation Pattern of Lambda Deoxyribonucleic Acid.
Methylation of Bacteriophage P1 DNA.
Temperature Dependence of Non-Electrolyte and Sodium Permeability in Giant Axon of Squid.
Effect of Temperature on Resting Potential in Giant Axons of Squid.
Effect of Temperature and Metabolic Inhibitors on Calcium-45 Outflow from Squid Giant Axons.
Sodium Transport Inhibition by Selective Mitochondrial Inhibitors in the Urinary Bladder of the Toad.

Review (5)

Crosstalk between calcium and redox signaling: From molecular mechanisms to health implications
A role for reactive oxygen/nitrogen species and iron on neuronal synaptic plasticity
Calcium microdomains and gene expression in neurons and skeletal muscle cells
The ryanodine receptors Ca2+ release channels: Cellular redox sensors?
Redox regulation of RyR-mediated Ca2+ release in muscle neurons

Editorial Material (2)

Getting to the Heart of Mechanotransduction
Redox Control of Brain Calcium in Health and Disease

Conference Paper (1)

TNP-8N 3-ADP photoinactivation of the phosphatase activity of FITC-modified SERCA

Nil Class (0)

103
Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

22
Gina Sánchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

8
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

8
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

6
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

6
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

5
Andrea Paula

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

5
Tatiana Adasme

Associate Professor, CIBQA Researcher

Centro Integrativo de Biología y Química Aplicada (CIBQA)

Universidad Bernardo OHiggins

Santiago, Chile

4
Steffen Hartel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

3
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Maria Behrens

Profesor Titular

Neurología y Neurocirugía, Farmacología

Hospital Clínico Universidad de Chile

Santiago, Chile

2
PAOLA HAEGER

Associated professor

Ciencias Biomedicas

Universidad Catolica del Norte

COQUIMBO, Chile

2
Berta Espinosa

Assistant Professor

Tecnología Médica

Universidad de Chile

Santiago, Chile

2
Roberto Bravo

Investigador Postdoctoral

Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile

Santiago, Chile

2
Juan Valdés

Head lab

Ciencias Biologicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

2
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

2
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Ulrike Kemmerling

Associate Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

2
Denise Riquelme

Adjunct Professor

Biology

Universidad de Santiago

Santiago, Chile

1
Rodrigo Troncoso

Assistant professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

1
Pabla Aguirre

Asistente de investigación

Biología

Universidad de Chile

Santiago, Chile

1
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Cesar Osorio

Associate Professor

Kinesiología

Universidad Metropolitana de Ciencias de la Educación

Santiago, Chile

1
Karen Castillo

Investigadora Joven

Laboratorio de Sensores Moleculares, Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso

Valparaiso, Chile

1
GABRIELA ZAVALA

Investigador post-doctoral

Cells for Cells

Universidad de los Andes

Santiago, Chile

1
Rodrigo Valenzuela

Profesor Titular

Universidad Católica Silva Henríquez

Santiago, Chile

1
Maria Aylwin

Associate Professor

Universidad de Talca

Talca, Chile