Man

Tatiana Marlene Adasme Rocha

Associate Professor, CIBQA Researcher

Universidad Bernardo OHiggins

Santiago, Chile

Líneas de Investigación


Synaptic plasticity and Memory; Calcium Signals; Redox signaling; Calcium and Redox regulated Transcriptional Factors; Signal transduction in Aging

Educación

  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 2004
  •  Biochemist bachelor, UNIVERSIDAD DE CHILE. Chile, 2004
  •  Doctor in Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2009

Experiencia Académica

  •   Teacher and coordinator Part Time

    Universidad de Artes, Ciencias y Comunicación (UNIACC)

    Santiago, Chile

    Enero 2014 - Enero 2015

  •   Physiology teacher Part Time

    Universidad San Sebastian

    Santiago, Chile

    Enero 2009 - Enero 2010

  •   Physiology teacher Part Time

    Universidad Autónoma

    Santiago, Chile

    Enero 2010 - Enero 2010

  •   Physiology teacher Full Time

    Universidad Bernardo O´Higgins

    Facultad de Ingeniería, Ciencias y Tecnología

    Santiago, Chile

    Enero 2017 - A la fecha

  •   Physiology teacher Full Time

    Universidad de Bernardo O´Higgins

    Health

    Santiago, Chile

    Enero 2016 - A la fecha

  •   Physiology teacher Part Time

    UNIVERSIDAD DE VALPARAISO

    Facultad de Medicina

    Santiago, Chile

    Enero 2006 - Enero 2006

  •   teacher for Intracellular Calcium signals course Part Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago , Chile

    Enero 2007 - Enero 2008

  •   Teacher for Biomedicine I and II Part Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    Enero 2014 - Enero 2018

  •   Teacher and evaluator of Research Units Other

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    Enero 2012 - Enero 2017

  •   teacher Part Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    Enero 2018 - A la fecha

  •   Physiology teacher Full Time

    Universidad Bernardo O´Higgins

    Health

    Santiago, Chile

    Enero 2016 - A la fecha

  •   laboratory teacher Part Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    Enero 2019 - A la fecha

Experiencia Profesional

  •   Researcher, FONDAP/CEMC Fellowship Full Time

    Universidad de Chile/Facultad de medicina/ Laboratorio de Señales de Calcio

    Santiago, Chile

    Enero 2009 - Enero 2011

  •   postdegree CONICYT fellowship Full Time

    Universidad de Chile/Facultad de medicina/ Laboratorio de Señales de Calcio

    Santiago, Chile

    Enero 2006 - Enero 2009

  •   Member of professional team, FONDECYT 1050768 Part Time

    Universidad de Chile/Facultad de Ciencias Químicas y Farmacéuticas/ Laboratorio de Transducción de señales moleculares de la célula

    Santiago, Chile

    Enero 2005 - Enero 2006

  •   member of Professional team proyecto FONDECYT 1050690 Part Time

    Universidad de los Andes/ Laboratorio de Bioquímica y Fisiología celular

    Santiago, Chile

    Enero 2004 - Enero 2005

  •   undergraduate in professional thesis Full Time

    Universidad de Chile/Facultad de Ciencias Químicas y Farmaceúticas/ Laboratorio de Transducción de señales

    Santiago, Chile

    Enero 2002 - Enero 2004

  •   student in laboratory Part Time

    Universidad de Chile/Facultad de Ciencias/ Laboratorio de Bioquímica

    Santiago, Chile

    Enero 1999 - Enero 2000

  •   Investigadora CIBQA Full Time

    Universidad Bernardo O´Higgins

    Santiago, Chile

    Enero 2016 - A la fecha

  •   BNI researcher in collaboration Part Time

    Universidad de Chile/Facultad de medicina/ Laboratorio de Señales de Calcio

    Santiago, Chile

    Enero 2014 - A la fecha

  •   Professor, Faculty of Medicine Part Time

    Universidad de Chile

    Santiago, Chile

    Enero 2019 - Enero 2019

Formación de Capital Humano


Training of Young Investigators
1. Undergraduated Thesis: Italo Espinoza Fuenzalida; “The field electrical stimulation modulates the RyR2 expression in primary hippocampal neurons”; 2007-2010; Universidad de Chile; CHILE; Thesis for to be Biochemist. Function: co-director; director: Dra. María Angélica Carrasco. Laboratorio de Bioquímica Celular, Facultad de Medicina, Universidad de Chile.

2. Undergraduated Thesis: Karla Cataldo, Patricio Farías; Daniela Meza; “Efecto de la Astaxantina sobre la translocación del Factor Nuclear kappa B en hipocampo de ratas envejecidas y en células PC12”; Universidad de Valparaíso; CHILE; Thesis for to be Medical Technologist. Function: co-advisor; advisor: Dr. Pablo Munoz. Laboratory of Cellular and Molecular Plasticity, Facultad de Medicina, Universidad de Valparaíso.

3. Magister Thesis: Bábara Bruna Jara; “Involvement of the transcription factor Nrf2 in the increases of RyR2 expression induced of BDNF.”; 2015-2017; Universidad de Chile; CHILE; Master in Biochemistry Thesis. Function: co-director; Director: Dra. Andrea Paula-Lima. Laboratory of Celular and Molecular Biology, Faculty of Dentistry, Universidad de Chile.
- Professional trainee: Italo Espinoza Fuenzalida; “Detection of peroxide in hippocampal primary neurons stimulated electrically” Function: Chief professor. Laboratory of Celular Biochemistry, Faculty of Medicine, Universidad de Chile.

4. Magister Thesis: Marilyn Fonseca; “ Effects of beta-amyloid oligomers on Nrf2 nuclear translocation and expression of antioxidant enzymes in primary hippocampal neurons”; 2018 – in course; Universidad Bernardo O´Higgins; CHILE; Master in Chemical and Biological Sciences. Function: Advisor; co-advisor: Dra. Andrea Paula-Lima. Laboratory of Cellular and Molecular Biology, Faculty of Dentistry, Universidad de Chile.

Early scientific training for undergraduate and post degree students.

1. 2012-2019: 19 Undergraduate students, Medicine School (second year), Faculty of Medicine, Universidad de Chile. Function: Tutor. Laboratory of Calcium Signals, Faculty of Medicine, Universidad de Chile.
2. 2017-2017: 1 Postdegree student, Pharmacology program of PhD, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile.
2. 2008-2017: 8 Undergraduate students, Biochemistry School (second year), Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile.
3. 2012: 1 Undergraduate student, Pharmacy and Chemistry School (4Th), Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile.


Difusión y Transferencia


1. Project for development of critical and scientific thinking in students of middle education at Instituto Miguel León Prado. October-December 2015 and 2018.

2. Internship at the Institute of Neurobiology of Magdeburg, Germany, Leibniz Institute for Neurobiology (LIN), preparation of joint research project with Dr. Rodrigo Herrera Molina, Co-leader of the group in the Department of Neurochemistry and Molecular Biology of LIN . August 29 - September 13, 2017.

3. Project for the development of critical and scientific thinking for students of middle education at Instituto Miguel León Prado. October-December 2018.

4. Project for development of critical and scientific thinking for pre-basic and middle education students at Instituto Miguel León Prado. October-December 2015.
5. EXPLORA CONICYT; guide professor, Universidad de Chile, Open house Cicle 2008.

6. EXPLORA CONICYT: Cientific Committee evaluator, second stage of selected works evaluation, 8th School Meeting of Science and technology, EXPLORA CONICYT, Región Metropolitana, Universidad Católica de Chile, October 2013.


Premios y Distinciones

  •   Doctoral thesis fellowship AT-24080073

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2008

    Fellowship for the performing of doctoral thesis (complement to D-21060628) from CONICYT (Comisión Nacional de Investigación Científica y Tecnológica), AT-24080073, Gobierno de Chile, (2008).

  •   Doctoral Fellowship, CONICYT D-21060628

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2006

    CONICYT (Comisión Nacional de Investigación Científica y Tecnológica) Doctoral fellowship, D-21060628, Gobierno de Chile (2006-2009).

  •   Fellowship for Scientific Meeting assistance

    UNIVERSIDAD DE CHILE

    Chile, 2007

    Fellowship from Universidad de Chile for present and participate to the Course entitled “Neurochemical & Cellular Mechanism of Neuronal Damage. Therapeutical approaches”, Marzo 22-25, Pucón, Chile, 2007.

  •   Brazilian Academy of Sciencies 13rd TWAS-ROLAC

    The World Academy of Science

    Chile, 2013

    Awarded with fellowship to travel and preset my research (poster session) in “13rd TWAS-ROLAC Young Scientists Conference ”. Río de Janeiro, 6-8 de Mayo, 2013.

  •   Chilean Neuroscience society fellowship

    Chilean Society of Neuroscience

    Chile, 2013

    Awarded for travel and present my postdegree research in the session of Young Neuriscientist meeting, " IX Annual Meeting of Chilean Neurosciente Society and VIII Meeting of Latinoamerican Biophysics. Valparaíso, 1-4 de Octubre, 2013, Chile.

  •   FONDEQUIP Technical committee member

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2019

    Member of national committee of Fund of scientific and technologic equipment from January 2019.

  •   Member of Group III: Bioanalitical Instruments Evaluator

    FONDEQUIP

    Chile, 2018

    Member of evaluation pannel.


Tipos de Producción
 

Article (13)

Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K
Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats
Aging Impairs Hippocampal-Dependent Recognition Memory and LTP and Prevents the Associated RyR Up-regulation
Development of an iron-selective antioxidant probe with protective effects on neuronal function
RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid beta Peptide Oligomers
Astaxanthin protects primary hippocampal neurons against noxious effects of A ?-oligomers
Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons
The Antioxidant N-Acetylcysteine Prevents the Mitochondrial Fragmentation Induced by Soluble Amyloid-beta Peptide Oligomers
Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF
High-Frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-Mediated Ca2+ Release and Generates Hydrogen Peroxide, Which Jointly Stimulate NF-kappa B Activity
Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation
The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling

Conference Poster (9)

BDNF through RyR-mediated Ca2+ release and ROS signaling induces Nrf2 translocation in hippocampal neurons.
BDNF-induced hippocampal structural plasticity requires ROS-stimulated RyR2-mediated Ca2+ release.
Ryanodine receptor mediated calcium signals and ROS jointly mediate BDNF-induced Nrf2 nuclear translocation in primary hippocampal neurons.
“Anomalous Calcium/Redox signaling in rats exposed to amyloid b-oligomers: Function and behavioral correlates with early Alzheimer patients.”
“Ca2+ and ROS participate in BDNF signaling: a novel role for Nrf2”
“Calcium signals evoked in dendrites of primary rat hippocampal neurons engage RyR2- mediated calcium reléase for propagation to the nucleus.”
“RyR2-mediated Calcium release has a key role in hippocampal synaptic plasticity and memory processes and its defective in a rat model of Alzheimer disease.”
BDNF increase RyR2 expression through Ca2+ and ROS signaling induced Nrf2 translocation in hippocampal neurons.
Neuronal structural plasticity and LTP induction require Ryanodine Receptor mediated Ca2+ release.

Grant (5)

“Modulacion redox de reguladores transcripcionales en neuronas de hipocampo”.

Dtp Import/Article (3)

Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training
The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling.
IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB.

Review (1)

Contribution of Ca2+ Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation
28
Tatiana Adasme

Associate Professor, CIBQA Researcher

Centro Integrativo de Biología y Química Aplicada (CIBQA)

Universidad Bernardo OHiggins

Santiago, Chile

7
Andrea Paula

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

5
Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

3
Gina Sánchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

2
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Jose Valdes

Profesor Asistente

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Steffen Hartel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

2
JAMILETH MORE

Asistente de Investigación

Fisología y Biofisica

Universidad de Chile

Santiago, Chile

1
Juan Valdés

Head lab

Ciencias Biologicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
PAOLA HAEGER

Associated professor

Ciencias Biomedicas

Universidad Catolica del Norte

COQUIMBO, Chile

1
Rodrigo Herrera Molina

Group Leader (staff member)

Neurochemistry and Molecular Biology

Leibniz Institute for Neurobiology

Magdeburg, Alemania

1
Denise Riquelme

Adjunct Professor

Biology

Universidad de Santiago

Santiago, Chile

1
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Roberto Bravo

Investigador Postdoctoral

Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile

Santiago, Chile