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MANUEL ALEJANDRO VARAS GODOY

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Tumor Microenvironment; Extracellular Vesicles; Cancer Stem Cells, Cell Signaling

Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2004
Biotechnology, UNIVERSIDAD ANDRES BELLO. Chile, 2012
Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2006

Assistant Professor Full Time

UNIVERSIDAD DE LOS ANDES

Medicine

Santiago, Chile

2016 - 2019
Research Professor Full Time

UNIVERSIDAD DE LOS ANDES

Medicine

Santiago, Chile

2015 - 2016
Assistant Professor Full Time

UNIVERSIDAD SAN SEBASTIAN

Medicine and Science

Santiago, Chile

2019 - 2020
Associate Professor Full Time

UNIVERSIDAD SAN SEBASTIAN

Medicine and Science

Santiago, Chile

2020 - A la fecha

Professor Physiology Part Time

UCINF

Santiago, Chile

2012 - 2012
Academic Assistant Part Time

Universidad Andres Bello

Santiago, Chile

2009 - 2011
Research Assistant Part Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2007 - 2008
Postdoctoral Research Full Time

Karolinska Institutet

Stockholm, Suecia

2012 - 2015
Research Professor Full Time

Universidad de los Andes

Santiago, Chile

2015 - 2019
Research Professor Full Time

Universidad San Sebastián

Santiago, Chile

2019 - A la fecha

Graduated Students

1. Constanza Pinochet, Bachelor in Biothecnology, UNIVERSIDAD DE LA FRONTERA, 12 March 2013, (Supervisor).

2. Paula Valenzuela, Master in Biotechnology, UNIVERSIDAD ANDRES BELLO, 21 April 2016 (Co-supervisor).

3. Sebastián Venegas, Bachelor in Molecular Biotechnology, UNIVERSIDAD DE CHILE, 28 July 2017 (Co-supervisor).

4. Evelyn Zirotti, Bachelor in Biothecnology, UNIVERSIDAD DE LA FRONTERA, 18 December 2017 (Supervisor).

5. Gonzalo Gomara, Master in Biotechnology, UNIVERSIDAD ANDRES BELLO, 19 December 2018 (Co-supervisor).

6. Felipe Grunenwald, Bachelor in Biothecnology, UNIVERSIDAD MAYOR, 17 April 2020 (Supervisor).

7. Nelly Vera, Bachelor in Biothecnology, UNIVERSIDAD MAYOR, 9 June 2020 (Supervisor).

8. Daniela Riveros, Medical Technology,, UNIVERSIDAD SAN SEBASTÍAN, 25 November 2020 (Supervisor).

9. Javiera Portus, Biochemist, UNIVERSIDAD SAN SEBASTÍAN, 5 August 2021 (Supervisor).

10. Cristobal Cerda, PhD in Cell Biology and Biomedicine, UNIVERSIDAD SAN SEBASTIÁN, 4 April 2022 (Co-supervisor).

11. Liseth Orosco, Bachelor in Biology, UNIVERSIDAD NACIONAL DE SAN AGUSTIN, AREQUIPA, PERU, 8 June 2022 (Supervisor).

12. Albano Cáceres, PhD in Biomedicine, UNIVERSIDAD DE LOS ANDES, 13 June 2022 (Supervisor).

13. Jonathan Lillo, Biothecnology, UNIVERSIDAD TECNOLÓGICA METROPOLITANA, 2 July 2022 (Supervisor).

Current Students

1. Jorge Catalan, PhD in Cell Biology and Biomedicine, UNIVERSIDAD SAN SEBASTIAN, (Supervisor).

2. Javiera Portus, Master in Molecular Biomedicine, UNIVERSIDAD SAN SEBASTÍAN, (Supervisor).

3. Beatriz Caceres, Biochemist, UNIVERSIDAD SAN SEBASTÍAN, (Supervisor).

Postdoc

1. Francisca Alvarez, ANID, 2020-

Selected Conference 2016-2019

1. Cáceres-Verschae A, Varas-Godoy M. IL-8/CXCR1 activation induces cancer stem-like cells properties in ovarian cancer cells. Chilean Society for Cell Biology – XXXIII Annual Meeting – November 25-29, 2019. Puerto Varas, Chile.

2. Cerda-Troncoso C, Alvarez F, Gaete-Ramirez B, Varas-Godoy M, and Burgos PV. Characterization of multivesicular bodies (MVBs) in chemoresistance ovarian cancer cells with reduced macroautophagy. Chilean Society for Cell Biology – XXXIII Annual Meeting – November 25-29, 2019. Puerto Varas, Chile. Puerto Varas, Chile.

3. Cerda-Troncoso C, Alvarez F, Gaete-Ramirez B, Varas-Godoy M, and Burgos PV. Role of microautophagy (eMI) during chemotherapy resistance to cisplatin in ovarian cancer cells. EMBO Workshop - Proteostasis: From organelles to organisms - November 15-19, 2019. Ericeira, Portugal

4. Iva Polakovicova, Edison Salas-Huenuleo, Lorena Lobos-González, Manuel Varas-Godoy, Nicolas Carrasco-Veliz, Alejandro Corvalán. Role of microRNA-335-5p in gastric cancer derived extracellular
vesicles. Annual Meeting International Society for Extracellular Vesicles. Barcelona, España, 2018.

5. Edison Salas-Huenuleo, Iva Polakovicova, Manuel Varas-Godoy, Lorena Lobos-González, Julian Bejarano, Alejandro Corvalán, Marcelo J. Kogan. A simple method to label vesicles for visualization and in vivo
tracking. Annual Meeting International Society for Extracellular Vesicles. Barcelona, España, 2018.

6. Albano Cáceres-Verschae, Sofia Cubillos, Sebastian E. Illanes, Manuel Varas-Godoy. Extracellular vesicles derived from ovarian cancer sphere increase tumorigenic properties of low invasive ovarian cancer cells. XXXI Annual Meeting Chilean Society for Cell Biology. Puerto Varas, Chile, 2017.

7. America Campos, Lorena Lobos-González, Rocio Bustos, Manuel Varas-Godoy, Carlos Salomon, Andrew FG. Quest. Caveolin-1-containing exosomes from metastatic breast cancer cells contain adhesion
proteins and enhance migration in recipient cells. XXXI Annual Meeting Chilean Society for Cell Biology. Puerto Varas, Chile, 2017.

8. Lobos-Gonzalez L, Bustos R, Campos A V, Silva V, Carrasco M, Guevara F, Varas-Godoy M, Oliveira L, Burzio V, 6 , Burzio L. Exosomes from metastatic breast cancer cells post-interference of ncmtRNAs decreased metastasis in a model of carcinomatosis intraperitoneally. XXXIX Annual Meeting Chilean Society for Biochemistry and Molecular Biology. Puerto Varas, Chile, 2016.

9. Bustos R, Campos A, Varas-Godoy M, Carrasco M, Guevara F, Villegas J, Burzio V, Burzio L, Lobos Gonzalez L. Exosomes released upon knockdown of the antisense non-coding mitochondrial rnas modulate tumorigenic properties of the human breast cancer cell line MDA-MB-231. XXXIX Annual Meeting Chilean Society for Biochemistry and Molecular Biology. Puerto Varas, Chile, 2016.

10. Alejandro Luarte, Roberto Henzi, Juan Pablo Ramírez, Matías Masalleras, Isabel Villalobos, Manuel Varas, Úrsula Wyneken. Astrocyte-derived exosomes interact with neurons decreasing neuritic branching. XXX Annual Meeting Chilean Society for Cell Biology. Puerto Varas, Chile, 2016.

FUNDACION ARAUCARIA

SOCIEDAD CHILENA DE CARDIOLOGIA Y CIRUGIA CARDIOVASCULAR

Chile, 2006

Best work on heart disease award, Chilean Cardiology Congress
NOVARTIS LABORATORY

SOCIEDAD CHILENA DE CARDIOLOGIA Y CIRUGIA CARDIOVASCULAR

Chile, 2007

Best original work published in Chile's Cardiology
National Doctoral Scholarships 2008

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2008

Doctoral Fellowship
Student National Travel Fellowship

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2010

Conicyt Student Travel Fellowship, Chilean Society for cell Biology
Student National Travel Fellowship

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2011

Conicyt Student Travel Fellowship, Chilean Society for cell Biology
Student International Travel Fellowship

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2011

Conicyt Student international Travel Fellowship
Post-Doctoral Fellowship

KAROLINSKA INSTITUTE

Suecia, 2013

Karolinska Institutet Post-Doctoral Fellowship


H3K9 Methyltransferases Suv39h1 and Suv39h2 Control the Differentiation of Neural Progenitor Cells in the Adult Hippocampus Guerra, Miguel V.; Caceres, Matias I.; Herrera-Soto, Andrea; Arredondo, Sebastian B.; Varas-Godoy, Manuel; van Zundert, Brigitte; Varela-Nallar, Lorena Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)
Convergent Met and voltage-gated Ca 2+ channel signaling drives hypermigration of Toxoplasma -infected dendritic cells Ólafsson, Einar B.; ten Hoeve, Arne L.; Li-Wang, Xiaoze; Westermark, Linda; Varas-Godoy, Manuel; Barragan, Antonio Article WOS Core Collection ISI Journal of Cell Science (2021)
Dietary Fructose Promote Prostate Cancer Growth Carreño, Daniela; Corro, Nestor; Cerda-Infante, Javier; Echeverria, Carolina; Ascencio-Barría Catalina; Torres-Estay, Veronica; Mayorga-Weber, Gonzalo; Rojas, Pablo A.; Veliz, Loreto P.; Cisternas, Pedro; Montecinos, Viviana P.; San Francisco, Ignacio F.; Varas-Godoy, Manuel; Sotomayor, Paula C.; Castro, Maite A.; Nualart, Francisco J.; Inestrosa, Nibaldo C; Godoy, Alejandro S. Article WOS Core Collection ISI CANCER RESEARCH (2021)
eNOS-dependent S-nitrosylation of the NF-kappa B subunit p65 has neuroprotective effects Caviedes, Ariel; Maturana, Barbara; Corvalan, Katherina; Engler, Alexander; Gordillo, Felipe; Varas-Godoy, Manuel; Smalla, Karl-Heinz; Batiz, Luis Federico; Lafourcade, Carlos; Kaehne, Thilo; Wyneken, Ursula Article ISI CELL DEATH DISEASE (2021)
Overexpression of DAZL, STRA8, and BOULE Genes and Treatment With BMP4 or Retinoic Acid Modulate the Expression of MSC Overexpressing Germ Cell Genes Cordero, Paloma; Guerrero-Moncayo, Alejandra; De los Reyes, Monica; Varas-Godoy, Manuel; Cortez, Jahaira; Torres, Cristian G.; Parraguez, Victor H.; Peralta, Oscar A. Article ISI FRONTIERS IN VETERINARY SCIENCE (2021)
Pro-Tumoral Functions of Autophagy Receptors in the Modulation of Cancer Progression Cerda-Troncoso, Cristobal; Varas-Godoy, Manuel; Burgos, Patricia V. Article ISI FRONTIERS IN ONCOLOGY (2021)
A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites Bhandage, Amol K.; Olivera, Gabriela C.; Kanatani, Sachie; Thompson, Elizabeth; Lore, Karin; Varas-Godoy, Manuel; Barragan, Antonio Article ISI ELIFE (2020)
Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity Luarte, Alejandro; Henzi, Roberto; Fernández, Anllely; Gaete, Diego; Cisternas, Pablo; Pizarro, Matias; Batiz, Luis Federico; Villalobos, Isabel; Masalleras, Matias; Vergara, Rodrigo; Varas-Godoy, Manuel; Abarzua-Catalan, Lorena; Herrera-Molina, Rodrigo; Lafourcade, Carlos; Wyneken, Ursula Article Wos Core Collection ISI CELLS (2020)
Connexin-46 Contained in Extracellular Vesicles Enhance Malignancy Features in Breast Cancer Cells Acuna, Rodrigo A.; Varas-Godoy, Manuel; Berthoud, Viviana M.; Alfaro, Ivan E.; Retamal, Mauricio A. Article ISI Biomolecules (2020)
Endothelin-converting enzyme-1c promotes stem cell traits and aggressiveness in colorectal cancer cells PÃ©rez-Moreno P.; Indo S.; Niechi I.; Huerta, H.; Cabello P.; Jara L.; Aguayo F.; Varas-Godoy M.; Burzio, V.A.; Tapia, J.C. Article ISI SCOPUS MOLECULAR ONCOLOGY (2020)
Exosomes released upon mitochondrial ASncmtRNA knockdown reduce tumorigenic properties of malignant breast cancer cells Lobos-GonzÃ¡lez L.; Bustos R.; Campos A.; Silva V.; Silva V.; Jeldes E.; Salomon C.; Varas-Godoy M.; CÃ¡ceres-Verschae A.; Duran E.; Vera T.; Ezquer F.; Ezquer M.; Burzio, V.A.; Villegas J. Article SCOPUS SCIENTIFIC REPORTS (2020)
Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors Lara, Pablo; Palma-Florez, Sujey; Salas-Huenuleo, Edison; Polakovicova, Iva; Guerrero, Simon; Lobos-Gonzalez, Lorena; Campos, America; Munoz, Luis; Jorquera-Cordero, Carla; Varas-Godoy, Manuel; Cancino, Jorge; Arias, Eloisa; Villegas, Jaime; Cruz, Luis J.; Albericio, Fernando; Araya, Eyleen; Corvalan, Alejandro H.; Quest, Andrew F. G.; Kogan, Marcelo J. Article ISI SCOPUS JOURNAL OF NANOBIOTECHNOLOGY (2020)
Increased Circulating Levels of Tissue-Type Plasminogen Activator Are Associated with the Risk of Spontaneous Abortion During the First Trimester of Pregnancy Monteiro, Lara J.; Varas-Godoy, Manuel; Acuña-Gallardo, Stephanie; Correa, Paula; Passalacqua, Gianluca; Monckeberg, Max; Rice, Gregory E.; Illanes, Sebastián E. Article ISI SCOPUS DIAGNOSTICS (2020)
Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells Perez-Moreno, Pablo; Quezada-Meza, Camila; Chavez-Almarza, Cristopher; Niechi, Ignacio; Silva-Pavez, Eduardo; Trigo-Hidalgo, Cesar; Aguayo, Francisco; Jara, Lilian; Caceres-Verschae, Albano; Varas-Godoy, Manuel; Diaz, Victor M.; Garcia de Herreros, Antonio; Burzio, Veronica A.; Tapia, Julio C. Article ISI FRONTIERS IN ONCOLOGY (2020)
Srebf1 Controls Midbrain Dopaminergic Neurogenesis Toledo, Enrique M.; Yang, Shanzheng; Gyllborg, Daniel; van Wijk, Kim E.; Sinha, Indranil; Varas-Godoy, Manuel; Grigsby, Christopher L.; Lonnerberg, Peter; Islam, Saiful; Steffensen, Knut R.; Linnarsson, Sten; Arenas, Ernest Article ISI CELL REPORTS (2020)
The histone variant H3.3 regulates the transcription of the hepatitis B virus Alvarez-Astudillo, Francisca; Garrido, Daniel; Varas-Godoy, Manuel; Gutiérrez, José L.; Villanueva, Rodrigo A.; Loyola, Alejandra. Article WOS Core Collection ISI ANNALS OF HEPATOLOGY (2020)
The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells Rivas, Solange; Silva, Patricio; Reyes, Montserrat; Sepulveda, Hugo; Solano, Luis; Acuna, Juan; Guerrero, Marisol; Varas-Godoy, Manuel; Quest, Andrew F. G.; Montecino, Martin; Torres, Vicente A. Article ISI Scientific Reports (2020)
Wnt5a promotes differentiation and development of adult-born neurons in the hippocampus by noncanonical Wnt signaling Arredondo S.B.; Guerrero F.G.; Herrera-Soto A.; Jensen-Flores J.; Bustamante D.B.; OÃ±ate-Ponce A.; Henny P.; Varas-Godoy M.; Inestrosa N.C.; Varela-Nallar L. Article ISI SCOPUS STEM CELLS (2020)
Angiogenic Properties of Menstrual Stem Cells Are Impaired in Women with a History of Preeclampsia Varas-Godoy, Manuel; Acuna-Gallardo, Stephanie; Venegas-Duarte, Sebastian; Hill, Charlotte; Caceres-Verschae, Albano; Realini, Ornella; Monteiro, Lara J.; Zavala, Gabriela; Khoury, Maroun; Romero, Roberto; Rice, Gregory; Illanes, Sebastian E. Article ISI SCOPUS STEM CELLS INTERNATIONAL (2019)
BCG-induced cytokine release in bladder cancer cells is regulated by Ca2+ signaling Ibarra, C; Karlsson, M; Codeluppi, S; Varas-Godoy, M; Zhang, SB; Louhivuori, L; Mangsbo, S; Hosseini, A; Soltani, N; Kaba, R; Lundgren, TK; Tanaka, N; Oya, M; Wiklund, P; Miyakawa, A; Uhlen, P Article ISI SCOPUS Molecular Oncology (2019)
CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells Silva-Pavez, Eduardo; Villar, Paulina; Trigo, Cesar; Caamano, Esteban; Niechi, Ignacio; Perez, Pablo; Munoz, Juan P.; Aguayo, Francisco; Burzio, Veronica A.; Varas-Godoy, Manuel; Castro, Ariel F.; Colombo, Maria, I; Tapia, Julio C Article ISI SCOPUS CELL DEATH DISEASE (2019)
HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes Villota, Claudio; Varas-Godoy, Manuel; Jeldes, Emanuel; Campos, America; Villegas, Jaime; Borgna, Vincenzo; Burzio, Luis O.; Burzio, Veronica A. Article ISI SCOPUS AGING-US (2019)
Oral extracellular vesicles in early pregnancy can identify patients at risk of developing gestational diabetes mellitus Monteiro, Lara J.; Varas-Godoy, Manuel; Monckeberg, Max; Realini, Ornella; Hernandez, Marcela; Rice, Gregory; Romero, Roberto; Saavedra, Jose F.; Illanes, Sebastian E.; Chaparro, Alejandra Article ISI SCOPUS PLOS ONE (2019)
PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination Falcão, Ana Mendanha; Meijer, Mandy; Scaglione, Antonella; Rinwa, Puneet; Agirre, Eneritz; Liang, Jialiang; Larsen, Sara C.; Heskol, Abeer; Frawley, Rebecca; Klingener, Michael; Varas-Godoy, Manuel; Raposo, Alexandre A.S.F.; Ernfors, Patrik; Castro, Diogo S.; Nielsen, Michael L.; Casaccia, Patrizia; Castelo-Branco, Gonçalo Article ISI SCOPUS CELL REPORTS (2019)
Small Extracellular Vesicles in Rat Serum Contain Astrocyte-Derived Protein Biomarkers of Repetitive Stress Gomez-Molina, Cristobal; Sandoval, Mauricio; Henzi, Roberto; Pablo Ramirez, Juan; Varas-Godoy, Manuel; Luarte, Alejandro; Andres Lafourcade, Carlos; Lopez-Verrilli, Alejandra; Smalla, Karl-Heinz; Kaehne, Thilo; Wyneken, Ursula Article ISI INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2019)
Small Extracellular Vesicles Released from Ovarian Cancer Spheroids in Response to Cisplatin Promote the Pro-Tumorigenic Activity of Mesenchymal Stem Cells Vera, Nelly; Acuña-Gallardo, Stephanie; Grünenwald, Felipe; Caceres-Verschae, Albano; Realini, Ornella; Acuña, Rodrigo; LLadser, Alvaro; Illanes, Sebastián E.; Varas-Godoy, Manuel Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
TIMP-1 promotes hypermigration of Toxoplasma-infected primary dendritic cells via CD63-ITGB1-FAK signaling Olafsson, EB; Ross, EC; Varas-Godoy, M; Barragan, A Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2019)
Vesículas extracelulares como predictores tempranos de diabetes gestacional MARIO ARIAS; LARA J MONTEIRO; STEPHANIE ACUÑA-GALLARDO; Manuel Varas-Godoy,; GREGORY E RICE; MAX MONCKEBERG; PILAR DÍAZ; SEBASTIÁN E ILLANES Article SCIELO SCOPUS Revista Medica de Chile (2019)
Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines Campos A.; Salomon C.; Bustos R.; DÃaz J.; MartÃnez S.; Silva V.; Reyes C.; DÃaz-Valdivia N.; Varas-Godoy M.; Lobos-GonzÃ¡lez L.; Quest A.F. Article ISI SCOPUS (2018)
Effects of earthquake on perinatal outcomes: A Chilean register-based study Palmeiro-Silva, Yasna K.; Orellana, Pelusa; Venegas, Pia; Monteiro, Lara; Varas-Godoy, Manuel; Norwitz, Errol; Rice, Gregory; Osorio, Eduardo; Illanes, Sebastian E. Article ISI SCOPUS PLOS ONE (2018)
In vivo knockdown of antisense non-coding mitochondrial RNAs by a lentiviral-encoded shRNA inhibits melanoma tumor growth and lung colonization Varas-Godoy, M; Lladser, A; Farfan, N; Villota, C; Villegas, J; Tapia, JC; Burzio, LO; Burzio, VA; Valenzuela, PDT Article ISI SCOPUS PIGMENT CELL & MELANOMA RESEARCH (2018)
Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational diabetes mellitus Chaparro, Alejandra; Zúñiga, Edgardo; Varas-Godoy, Manuel; Albers, Daniela; Ramírez, Valeria; Hernández, Marcela; Kusanovic, Juan P; Acuña-Gallardo, Stephanie; Rice, Gregory; Illanes, Sebastián E. Article ISI SCOPUS JOURNAL OF PERIODONTOLOGY (2018)
Reduced FOXM1 Expression Limits Trophoblast Migration and Angiogenesis and Is Associated With Preeclampsia Monteiro, Lara J.; Cubillos, Sofia; Sanchez, Marianela; Acuña-Gallardo, Stephanie; Venegas, Pía; Herrera, Valentina; Lam, Eric W.-F.; Varas-Godoy, Manuel; Illanes, Sebastián E. Article ISI SCOPUS REPRODUCTIVE SCIENCES (2018)
Toxoplasma gondii infection shifts dendritic cells into an amoeboid rapid migration mode encompassing podosome dissolution, secretion of TIMP-1, and reduced proteolysis of extracellular matrix Olafsson, Einar B.; Varas-Godoy, Manuel; Barragan, Antonio Article ISI SCOPUS CELLULAR MICROBIOLOGY (2018)
Vaccination-induced skin-resident memory CD8(+) T cells mediate strong protection against cutaneous melanoma Galvez-Cancino, Felipe; Lopez, Ernesto; Menares, Evelyn; Diaz, Ximena; Flores, Camila; Caceres, Pablo; Hidalgo, Sofia; Chovar, Ornella; Alcantara-Hernandez, Marcela; Borgna, Vincenzo; Varas-Godoy, Manuel; Salazar-Onfray, Flavio; Idoyaga, Juliana; LLadser, Alvaro Article ISI SCOPUS ONCOIMMUNOLOGY (2018)
A short hairpin RNA-based adjuvant targeting NF-kappa B repressor I kappa B alpha promotes migration of dermal dendritic cells to draining lymph nodes and antitumor CTL responses induced by DNA vaccination Gálvez-Cancino, Felipe; Roco, Jonathan; Rojas-Colonelli, Nicole; Flores, Camila; Murgas, Paola; Cruz-Gómez, Sebastián; Oyarce, César; Varas-Godoy, Manuel; Sauma, Daniela; Lladser, Alvaro Article ISI SCOPUS VACCINE (2017)
Endothelial Nitric Oxide Synthase Is Present in Dendritic Spines of Neurons in Primary Cultures Caviedes, Ariel; Varas-Godoy, Manuel; Lafourcade, Carlos; Sandoval, Soledad; Bravo-Alegria, Javiera; Kaehne, Thilo; Massmann, Angela; Figueroa, Jorge P.; Nualart, Francisco; Wyneken, Ursula Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2017)
Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia Palmer, Kirsten R.; Kaitu’u-Lino, Tu’uhevaha J.; Cannon, Ping; Tuohey, Laura; De Silva, Manarangi S.; Varas-Godoy, Manuel; Acuña, Stephanie; Galaz, José; Tong, Stephen; Illanes, Sebastián E. Article ISI SCOPUS JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2017)
Physicochemical characterization of chitosan-hyaluronan-coated solid lipid nanoparticles for the targeted delivery of paclitaxel: A proof-of-concept study in breast cancer cells Campos J.; Varas-Godoy M.; Haidar Z.S. Article SCOPUS Nanomedicine (2017)
The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment Varas-Godoy M.; Rice G.; Illanes S.E. Article ISI SCOPUS STEM CELLS INTERNATIONAL (2017)
Voltage-dependent calcium channel signaling mediates GABA(A) receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii Kanatani, S; Fuks, JM; Olafsson, EB; Westermark, L; Chambers, B; Varas-Godoy, M; Uhlen, P; Barragan, A Article ISI SCOPUS PLOS PATHOGENS (2017)
Frizzled-1 receptor regulates adult hippocampal neurogenesis Mardones M.D.; Andaur G.A.; Varas-Godoy, M; Henriquez J.F.; Salech, F; Behrens, M. I.; couve, a; Inestrosa, N. C.; Varela-Nallar L. Article ISI SCOPUS Molecular Brain (2016)
Migratory activation of parasitized dendritic cells by the protozoan Toxoplasma gondii 14-3-3 protein Weidner, JM; Kanatani, S; Uchtenhagen, H; Varas-Godoy, M; Schulte, T; Engelberg, K; Gubbels, MJ; Sun, HS; Harrison, RE; Achour, A; Barragan, A Article ISI SCOPUS CELLULAR MICROBIOLOGY (2016)
Placental biomarkers and angiogenic factors in oral fluids of patients with preeclampsia Chaparro, A; Gaedechens D.; Ramírez V.; Zuñiga E; Kusanovic J.P; Inostroza C.; Varas-Godoy, M; Silva, K; Salomon, C; Rice, G; Illanes, S. E. Article ISI SCOPUS Prenatal Diagnosis (2016)
Prostate tumor-induced angiogenesis is blocked by exosomes derived from menstrual stem cells through the inhibition of reactive oxygen species Alcayaga-Miranda, F; Gonzalez, PL; Lopez-Verrilli, A; Varas-Godoy, M; Aguila-Diaz, C; Contreras, L; Khoury, M Article ISI SCOPUS ONCOTARGET (2016)
Targeting antisense mitochondrial ncRNAs inhibits murine melanoma tumor growth and metastasis through reduction in survival and invasion factors Lobos-González, Lorena; Silva, Verónica; Araya, Mariela; Restovic, Franko; Echenique, Javiera; Oliveira-Cruz, Luciana; Fitzpatrick, Christopher; Briones, Macarena; Villegas, Jaime; Villota, Claudio; VIDAURRE, SOLEDAD; Borgna, Vincenzo; Socias, Miguel; Valenzuela, Sebastián; López, Constanza; Socías, Teresa; Varas, Manuel; Díaz, Jorge; Burzio, Luis O.; Burzio, Verónica A. Article ISI SCOPUS ONCOTARGET (2016)
The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state Alarcon, V.; Hernandez S.; Rubio, L.; Alvarez, F.; Flores, Y.; Varas-Godoy, M; De Ferrari G.V.; Kann M.; Villanueva R.A.; Loyola, A. Article ISI SCOPUS SCIENTIFIC REPORTS (2016)
Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability Niechi, I; Silva, E.; Cabello, P; Huerta, H.; Carrasco, V; Villar, P.; Cataldo L.R.; Marcelain, K; Armisen, R; Varas-Godoy, M; Fernandez, C.; Tapia, J.C. Article SCOPUS Oncotarget (2015)
Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia Perez-Sepulveda, A; Monteiro, LJ; Dobierzewska, A; Espana-Perrot, PP; Venegas-Araneda, P; Guzman-Rojas, AM; Gonzalez Mi; Palominos-Rivera, M; Irarrazabal, CE; Figueroa-Diesel, H; Varas-Godoy, M; Illanes, SE Article ISI SCOPUS PLOS ONE (2015)
Sublethal Caspase Activation Promotes Generation of Cardiomyocytes from Embryonic Stem Cells Bulatovic, Ivana; Ibarra, Cristian; Osterholm, Cecilia; Wang, Heng; Beltran-Rodriguez, Antonio; Varas-Godoy, Manuel; Mansson-Broberg, Agneta; Uhlen, Per; Simon, Andras; Grinnemo, Karl-Henrik Article ISI PLOS ONE (2015)
The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons alfaro ie; Varela-Nallar, L; Varas-Godoy, M; Inestrosa, NC Article ISI SCOPUS Molecular and Cellular Neuroscience (2015)
Two Chronic Stress Models Based on Movement Restriction in Rats Respond Selectively to Antidepressant Drugs: Aldolase C As a Potential Biomarker Ampuero E.; Luarte, A; Santibañez M.; Varas-Godoy, M; Toledo, J; Diaz-Veliz, G; Cavada, G; Rubio, FJ; Wyneken, U Article ISI INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2015)
Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production Parodi, Jorge; Montecinos-Oliva, Carla; Varas, Rodrigo; Alfaro, Iván E.; Serrano, Felipe G.; Varas-Godoy, Manuel; Muñoz, Francisco J.; Cerpa, Waldo; Godoy, Juan A; Inestrosa, Nibaldo C Article ISI SCOPUS Molecular and Cellular Neuroscience (2015)
The glycolytic enzyme aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment Sandoval M.; Luarte, A; Herrera-Molina, R; Varas-Godoy, M; Santibañez M.; Rubio, FJ; Smit, AB; Gundelfinger ED; Li, KW; Smalla, KH; Wyneken, U Article ISI SCOPUS Brain Research (2013)
Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes Villota, C; Campos A.; Vidaurre S.; Oliveira-Cruz, L; Boccardo, E; Burzio, V.A.; Varas, M; Villegas, J; Villa L.L.; Valenzuela P.D.T.; Socias, M; Roberts, S.; Burzio L.O. Article ISI SCOPUS Journal of Biological Chemistry (2012)
Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro Ocaranza, MP; Lavandero S.; JALIL, JE; Moya, J; Pinto, M; Novoa U.; Apablaza F.; Gonzalez L.; Hernandez C.; Varas, M; Lopez R.; Godoy, I.; Verdejo H.; Chiong M. Article ISI SCOPUS Journal of Hypertension (2010)
Menores niveles tisulares de la enzima convertidora de angiotensina I homologa (ECA-2) y angiotensina-(1-9) están asociados a mayor remodelamiento de la pared aórtica de ratas hipertensas Ocaranza, Maria Paz; Moya, Jackeline; Pinto, Melissa; Escudero, Nicolas; Valenzuela, Francisco; Varas, Manuel; Godoy, Ivan; Chiong, Mario; Lavandero, Sergio; Jalil, Jorge Article SCIELO Revista chilena de cardiología (2010)
Menor expresión de la Enzima convertidora de Angiotensina I Homóloga (ECA2) se asocia a mayor remodelamiento de la pared aórtica de ratas con niveles genéticamente elevados de Angiotensina II Ocaranza, Maria P; Moya, Jackeline; Valenzuela, Francisca; Varas, Manuel; Jalil, Jorge Article Revista chilena de cardiología (2008)
El aumento de la actividad y expresión de la Enzima convertidora de Angiotensina I Homologa (ECA2) inducido por enalapril se asocia a menor fibrosis e hipertrofia ventricular izquierda post infarto al miocardio en la rata Ocaranza, Maria P; Varas, Manuel; Godoy, Ivan; Nilo, Flavia; Mackenzie, Denisse; Alarcón, Miguel; Pinto, Melissa; Román Maritza; Lavandero, Sergio; Jalil, Jorge E. Article Revista chilena de cardiología (2007)
Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat Ocaranza, MP; Godoy, I.; JALIL, JE; Varas, M; Collantes, P; Pinto, M; Román M.; Ramírez C.; Copaja M; Diaz-Araya, G; Castro P. ; Lavandero S. Article ISI SCOPUS HYPERTENSION (2006)


Biological Role of Fructose in Prostate Cancer Godoy, Alejandro Samuel; Varas-Godoy, Manuel; Cancino, Jorge; Huidobro, Christian Proyecto (2022)
Centro Científico Tecnológico de Excelencia Ciencia & Vida Perez-Acle, T Proyecto (2021)
THE INTERPLAY BETWEEN PHOSPHORYLATION AND UBIQUITYLATION CONTROLS STABILIZATION OF HERPUD1 UNDER ER STRESS: POSSIBLE IMPLICATIONS ON TNBC AGGRESSIVENESS Burgos, Patricia V.; Varas-Godoy, Manuel.; Mardones, Gonzalo; Barrera María José Proyecto (2021)
CÉLULAS TUMORALES RESISTENTES A CISPLATINO TRANSFIEREN QUIMIORESISTENCIA A TRAVÉS DE LA LIBERACIÓN DE VESÍCULAS EXTRACELULARES INDUCIDAS POR LA QUIMIOTERAPIA EN UNA MANERA DEPENDIENTE DE LA ACTIVACIÓN DE MTORC1 Alvarez-Astudillo, Francisca; Varas-Godoy, Manuel. Proyecto (2020)
OVARIAN CANCER STEM CELLS PROMOTE MALIGNANCY THROUGH IL8/CXCR1-DEPENDENT RELEASE OF EXTRACELLULAR VESICLES FONDECYT (11190928) Proyecto 2019-2023 Inv. Responsable
Endothelin-converting enzyme-1c (ECE1c) as a novel predictor of poor cancer patient outcome. An in vitro and in vivo study. FONDECYT (1160889) Proyecto 2016-2020 Coinvestigador(a)
Exosomes Released from Ovarian Cancer Stem Cells in Response to Chemotherapy Promote Pro-tumorigenic Properties of Mesenchymal Stem Cells FONDECYT (11150624) Proyecto 2015-2018 Inv. Responsable
MECANISMOS DE PROTECCION CARDIOVASCULAR DEPENDIENTES DE LA ENZIMA CONVERTIDORA DE ANGIOTENSINA I HOMOLOGA (ECA2) EN LA HIPERTENSION ARTERIAL EXPERIMENTAL. FONDECYT (1070662) Proyecto 2007-2010 Personal técnico y/o de apoyo
Enzima Convertidora de Angiotensina I Homologa (ECA-2) en la Disfunción Ventricular Izquierda Experimental FONDECYT (1040832) Proyecto 2004-2007 Tesista
FONDEF IDeA: Design of a prenatal screening for the early diagnosis of preeclampsia based on the detection of placental and endothelial biomarkers in oral fluids of pregnant women chaparro, alejandra; Illanes, Sebastián; Varas, Manuel; Hernandez, Marcela; Kusanovic, Juan Proyecto (0)


Harnessing the Angiogenic Potential of Stem Cell-Derived Exosomes for Vascular Regeneration Alcayaga-Miranda, F; Varas-Godoy, M; Khoury, M Review ISI SCOPUS (2016)
An integrated mechanism of cardiomyocyte nuclear Ca2+ signaling Ibarra C, Vicencio JM, Varas-Godoy M, Jaimovich E, Rothermel BA, Uhlén P, Hill JA, Lavandero S Review ISI SCOPUS JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)

MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Lara Jorge

Profesora Asistente

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

Stephanie Acuña

Asistente de Investigación

Facultad de Medicina

Universidad de los Andes

Santiago, Chile

Verónica Burzio

Investigadora Asociada

Fundacion Ciencia y Vida

Santiago, Chile

Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

jaime villegas

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Alejandro Luarte

Profesor Investigador

Neurociencias

Universidad de Los Andes

santiago, Chile

Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

JORGE JALIL

FULL PROFESSOR

ENFS CARDIOVASCULARES

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE MEDICINA

Santiago, Chile

Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

Pia Venegas

Asesora Técnica

Dirección de salud

Desafío Levantemos Chile

Santiago, Chile

Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Max Monckeberg

Profesor Investigador Asistente.

Ginecología Obstetricia y Biología de la Reproducción.

Universidad de Los Andes.

Santiago, Chile

Luis Burzio

Scientific Director

Andes Biotechnologies

FUNDACION CIENCIA PARA LA VIDA

Santiago, Chile

Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

Julio Tapia

Profesor Asociado

Oncologia Basico Clinica

Universidad de Chile

Santiago, Chile

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

PABLO PEREZ

Profesor investigador

Programa de Comunicación en Cáncer

Universidad del Desarrollo

Santiago, Chile

Eduardo Silva

Investigador Postdoctoral

Universidad Mayor

Santiago, Chile

Claudio Villota

Profesor/investigador Asociado

Facultad de Salud

Universidad Bernardo O'Higgins

Santiago, Chile

Ariel Caviedes

Postdoctorado

Escuela de psicología

Universidad Adolfo Ibánez

Santiago, Chile

Vincenzo Borgna

Investigador

Inmuno-Oncología

FUNDACION CIENCIA VIDA

Santiago, Chile

Valeria Ramirez

Profesor asociado

Facultad de Odontología

Universidad de Los Andes

Santiago, Chile

Maroun Khoury

Professor

Faculty of Medicine

Universidad de Los Andes

santiago, Chile

Juan Kusanovic

Jefe CIMAF

Obstetricia y Ginecología

SERV. DE SALUD METROPOLITANA SUR ORIENTE, HOSPITAL SOTERO DEL RIO

Santiago, Chile

Lilian Jara

Titular Professor

Human Molecular Genetic

UNIVERSIDAD DE CHILE / FACULTAD DE MEDICINA

Santiago, Chile

JULIO TAPIA

Full Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Rodrigo Acuña

Profesor Asistente Investigador

Medicina

Universidad del Desarrollo

Santiago, Chile

Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

Paulina Villar

Tesista doctorado en bioquímica

Bioquímica

Universidad de Chile

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

Felix Diaz

Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

Eduardo Ezquer

Director/Full Professor

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

Eyleen Araya

Academic

Chemical Sciences

Universidad Andres Bello

santiago, Chile

Simon Guerrero

Investigador

Instituto de Investigación Interdisciplinar en Ciencias Biomédicas SEK

Universidad SEK

Santiago, Chile

Paola Murgas

Profesor Investigador Asistente

Facultad de Ciencias

Universidad Austral de Chile

Valdivia , Chile

Juan Godoy

Tecnologo Medico

Laboratorio Clinico Cruz del Sur

Santiago, Chile

Cesar Oyarce Diaz

Posdtoc

MMB

UMCG

Groningen, Holanda

Sofía Hidalgo

Investigadora Postdoctoral

Departamento de Biología

Universidad de Chile

Santiago, Chile

Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

Edison Salas

Director de laboratorio de nanotecnología

Aintech

Santiago, Chile

carolina inostroza

investigador

Universidad de Los Andes

Santiago, Chile

Ximena Diaz

Asistente de investigación

Fundación ciencia y vida

Santiago, Chile

Francisca Alcayaga

Profesor Asociado

Facultad de Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

Ariel Castro

Full Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

Francisco Aguayo

Profesor Asociado

Programa de Virología, Instituto de Ciencias Biomédicas (ICBM)

Universidad de Chile

Santiago, Chile

gabriela zavala

Investigador post-doctoral

Cells for Cells

Universidad de los Andes

Santiago, Chile

Carlos Lafourcade

Profesor Asociado

UNIVERSIDAD DE LOS ANDES

Chile

Christopher Fitzpatrick

Postoctoral Researcher

Non coding RNAs

Fundación Ciencia y Vida

Santiago, Chile

Rodrigo Herrera

Group Leader (staff member)

Combinatorial NeuroImaging Core Facility

Leibniz Institute for Neurobiology

Magdeburg, Alemania

César Trigo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

Franko Restovic

Manager

Bioeconomy

Fundación Fraunhofer Chile Research

Santiago, Chile

Jorge Cancino

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

Emma Hernandez

Académico 44 h, profesor titular

Oral Patology and Medicine

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

Pablo Valenzuela

Founder and Scientific Director

Fundación Ciencia & Vida

Santiago, Chile

Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile

Maria Loyola

Principal Investigator

Fundación Ciencia & Vida

Santiago, Chile

Hugo Verdejo

Profesor Asociado

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

ALEJANDRO CORVALAN

Principal Investigator

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Giancarlo De Ferrari

Full Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Pablo Henny

Profesor Asociado

Anatomía Normal

Pontificia Universidad Católica de Chile

Santiago, Chile

Leticia Gonzalez

Profesional Apoyo a la Investigacion

Pontificia Universidad Católica de Chile

Santiago, Chile

Charlotte Hill

Postdoctoral Fellow

Pedriatrics

Boston Childrens Hospital, Harvard Medical School

Boston, Estados Unidos

Evelyn Menares

investigador postdoctoral

programa disciplinario de inmunología

Universidad de Chile

santiago, Chile

jaime villegas

Investigador Senior

Andes Biotechnologies

Fundación Ciencia para la Vida

Santiago, Chile

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

Yasna Palmeiro

Research Fellow

Institute for Global Health

University College London

London, Reino Unido

Felipe Gordillo

UNIVERSIDAD CATÒLICA DEL MAULE

Talca, Chile

Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

Rodrigo Varas

Profesor Asociado

Universidad Autónoma de Chile

Talca, Chile

Jorge Parodi

Director de laboratorio

Universidad Mayor de Chile

Temuco, Chile

Gabriel Cavada

Académico, Jefe de Programa

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

Luis Solano

Asistente de investigación

Universidad de Chile

Santiago, Chile

Patricio Silva

Investigados Postdoctoral

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile

Nicole Farfán

Asistente de investigación

instituto de ciencias biomedicas

Universidad del Desarrollo

Santiago, Chile

Sebastián Indo

Assistant Professor

Department of Medical Technologist

Universidad de Chile

Santiago, Chile

Mauricio Sandoval

Lab Manager

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Cristian Torres

Profesor Asociado

Ciencias Clínicas

Universidad de Chile

Santiago, Chile

Oscar Peralta

Profesor Asociado

Fomento de la Producción Animal

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Felipe Grunenwald

Postdoctoral Researcher

CIIB

Universidad de Los Andes

santiago, Chile

Maria del Pilar Díaz

Profesor Jornada

Medicina

Universidad de Los Andes

Santiago, Chile

Yvo Flores

Profesional (grado 12)

Biomédico

Instituto de Salud Pública

Santiago, Chile

MANUEL ALEJANDRO VARAS GODOY

Líneas de Investigación

Educación

Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2004

Biotechnology, UNIVERSIDAD ANDRES BELLO. Chile, 2012

Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2006

Experiencia Académica

Assistant Professor Full Time

Research Professor Full Time

Assistant Professor Full Time

Associate Professor Full Time

Experiencia Profesional

Professor Physiology Part Time

Academic Assistant Part Time

Research Assistant Part Time

Postdoctoral Research Full Time

Research Professor Full Time

Research Professor Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

FUNDACION ARAUCARIA

NOVARTIS LABORATORY

National Doctoral Scholarships 2008

Student National Travel Fellowship

Student National Travel Fellowship

Student International Travel Fellowship

Post-Doctoral Fellowship

Article (60)

Proyecto (10)

OVARIAN CANCER STEM CELLS PROMOTE MALIGNANCY THROUGH IL8/CXCR1-DEPENDENT RELEASE OF EXTRACELLULAR VESICLES

Endothelin-converting enzyme-1c (ECE1c) as a novel predictor of poor cancer patient outcome. An in vitro and in vivo study.

Exosomes Released from Ovarian Cancer Stem Cells in Response to Chemotherapy Promote Pro-tumorigenic Properties of Mesenchymal Stem Cells

MECANISMOS DE PROTECCION CARDIOVASCULAR DEPENDIENTES DE LA ENZIMA CONVERTIDORA DE ANGIOTENSINA I HOMOLOGA (ECA2) EN LA HIPERTENSION ARTERIAL EXPERIMENTAL.

Enzima Convertidora de Angiotensina I Homologa (ECA-2) en la Disfunción Ventricular Izquierda Experimental

Review (2)