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Valentina María Parra Ortiz

Profesora Asistente / Assistant Professor

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Mitochondrial dynamics and function; Stem Cells; Signal transduction in cardiac cells

Educación

  •  Bachelor on Biochemistry / Licenciatura en Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2003
  •  PhD on Biochemistry / Doctorado en Bioquímica, UNIVERSIDAD DE CHILE. Chile, 2011
  •  Biochemist / Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2006

Experiencia Académica

  •   Assistant Professor / Profesora Asistente Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    Enero 2016 - A la fecha

  •   Lecturer of General and Organic Chemistry Laboratories / Profesora de Laboratorios de Química General y Orgánica Part Time

    Universidad Santo Tomás

    UST - Facultad de Ciencias

    Santiago, Chile

    Enero 2008 - Enero 2008

  •   Physiology Lecturer / Profesora de Catedra, Fisiología Part Time

    UNIVERSIDAD AUTONOMA DE CHILE

    Facultad de Ciencias de la Salud

    Santiago, Chile

    Enero 2012 - Enero 2012

  •   Physiopathology Lecturer and Coordinator / Académica y Coordinadora de Cátedra, Fisiopatología Part Time

    UNIVERSIDAD ANDRES BELLO

    Santiago, Chile

    Enero 2015 - Enero 2016

Experiencia Profesional

  •   Undergraduate student, Biochemistry Bachelor Thesis / Tesista de Pregrado Full Time

    Centro FONDAP de Estudios Moleculares de la Celula, Universidad de Chile

    Santiago, Chile

    Enero 2005 - Enero 2007

  •   Laboratory Assistant / Ayuda Técnica de Laboratorio Full Time

    Centro FONDAP de Estudios Moleculares de la Celula, Universidad de Chile

    Santiago, Chile

    Enero 2007 - Enero 2007

  •   Graduate Student, PhD Thesis / Tesista de Postgrado, Doctorado. Full Time

    Centro FONDAP de Estudios Moleculares de la Celula, Universidad de Chile

    Santiago, Chile

    Enero 2007 - Enero 2011

  •   Postdoctoral Fellow / Investigador Postdoctoral Full Time

    Centro FONDAP de Estudios Moleculares de la Celula, Universidad de Chile

    Santiago, Chile

    Enero 2011 - Enero 2012

  •   Postdoctoral Fellow / Investigador Postdoctoral Full Time

    University of Texas Southwestern Medical Center

    Dallas, Estados Unidos

    Enero 2012 - Enero 2015

  •   Professor / Académica Full Time

    Universidad de Chile

    Santiago, Chile

    Enero 2016 - A la fecha

Formación de Capital Humano


Graduate Students

1. Gómez, Wileidy. 2018, Ph.D Degree on Integrative Genomics, Universidad Mayor.
Title: Disfunción en vías de degradación de organelos como vínculo entre el Síndrome de Down y Alzheimer.
State: In progress.

Undergraduate Students

1. Balboa, Karina. 2018, Profesional Degree: Pharmacist, Pontificia Universidad Católica de Chile.
Title: "Rol de la proteína ubiquitina ligasa E3 mitocondrial 1 (MUL1) en la desensibilización a la insulina y alteración del metabolismo mitocondrial inducido por palmitato".
State: In progress.

2. Cayupi, Jossete. 2018, Profesional Degree: Pharmacist, Universidad de Chile.
Title: "Vías de Señalización intracelular activadas por Resolvina E1 y Resolvina D1 en Fibroblastos Cardíacos".
State: Finished.

3. Arias, Carla. 2018, Profesional Degree: Biochemist, Pontificia Universidad Católica de Chile.
Title: “Inductores de mitofagia y su efecto en la diferenciación de cardiomiocitos derivados de células madres pluripotenciales inducidas (iPSC) de pacientes con trisomía de Síndrome de Down".
State: In progress.

4. Gómez, Andrés. 2017, Profesional Degree: Biochemist, Universidad de Chile.
Title: “Rol de la proteína RCAN1 en la mitofagia mediada por PINK1/PARKIN en cardiomiocitos derivados de células madres pluripotenciales inducidas (iPSC) de pacientes con trisomía de Síndrome de Down”.
State: Finished.

5. García, Macarena. 2017, Profesional Degree: Pharmacist, Pontificia Universidad Católica de Chile.
Title: "Relación de la proteína Ubiquitina Ligasa E3 Mitocondrial 1 (Mul1) con la conexión del Retículo endoplásmico (RE) y Mitocondria en células" musculares".
State: Finished.

6. Hernández, Carolina. 2016, Profesional Degree: Pharmacist, Pontificia Universidad Católica de Chile.
Title: “Rol de la Fisión Mitocondrial en el Cambio Metabólico Energético y Proliferación Celular en un Modelo Hipóxico de Células Pulmonares Arteriales Humanas de la Musculatura Lisa (hPASMC)”.
State: Finished.

7. Rivera, Pablo. 2012, Profesional Degree: Pharmacist, Universidad de Chile.
Title: “Regulación de la morfología mitocondrial del cardiomiocito por Angiotensina-(1-9)”.
State: Finished.

8. Sotomayor, Cristian. 2012, Profesional Degree: Pharmacist, Universidad de Chile.
Title: “Angiotensina (1-9) en la señalización del calcio mitocondrial en el cardiomiocito”
State: Finished.


Difusión y Transferencia


January 2nd, 2019, Interview for the Society of Biochemistry and Cell Biology of Chile: “Mitocondria, Células Madre y Bioinformática: Una nueva mirada para la Insuficiencia Cardíaca“. http://www.sbbmch.cl/?p=22966

2017-2018, Secretaría de Extensión, Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile.

April 5th, 2018. Participation in the Radial Program: "A tu Salud". Radio Universidad de Chile.
https://radio.uchile.cl/programas/a-tu-salud/460034/

April 19th, 2018. Interview for the Society of Biochemistry and Cell Biology of Chile: “Dra. Valentina Parra: Desde los infartos al Síndrome de Down”?
http://www.sbbmch.cl/?p=17044

March 30th, 2018. Scientific Dissemination Text: “Entendiendo la Ciencia: El Gen 1 de la Región Crítica del Síndrome de Down o RCAN1, ayuda en la mantención de una red mitocondrial Fusionada”. Website FONDAP Center for Chronic Diseases (ACCDiS).
http://www.accdis.cl/entendiendo-la-ciencia-el-gen-1-de-la-region-critica-del-sindrome-de-down-o-rcan1- ayuda-en-la-mantencion-de-una-red-mitocondrial-fusionada/

March 29th, 2018, Interview for the Secretary of Communications Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
http://www.uchile.cl/noticias/142123/academica-valentina-parra-publico-articulo-circulation-research

May, 2017. Start of activities as the new Secretary of Extension for the Department of Biochemistry and Molecular Biology, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile.

July 24-28th, 2017. Participation in the Graduate Winter School for Conosur Students with the activity: Rediscovering the Cell. Confocal Microscopy Techniques. Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Faculty of Biology, Pontificia Universidad Católica de Chile.

August, 2017. Participation in the Initiative of Videos of Chilean Women in Sciences. School version. Organized by the Chilean Academy of Sciences. Student: Paloma Kohl.?
https://www.youtube.com/watch?v=IX7BzjpYjMU&t=62s

September 22th, 2017. Participation in the activity "A Day with a Scientist" organized by the Proyecto Asociativo Regional Explora de CONICYT Región Metropolitana Zona Sur Oriente, and held in the Laboratory of Cellular Differentiation and Metabolism, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile. Student: Valentina Reyes.

October 5th, 2017. Coordinator and Cheer in the Center (CEMC) Exercise, Metabolism and Cancer - EXPLORA Activity 2017. Organized by the FONDAP Centers for Molecular Studies of the Cell (CEMC) and the Advanced Center for Chronic Diseases (ACCDiS), University of Chile. Visit to the facilities of the different Laboratories of the CEMC and ACCDiS Centers by High School Students from different districts of Santiago in October of 2017.

October 13th, 2017. Participation with the talk entitled: "Cell Therapies" at the V Science and Technology Fair organized by Liceo San Francisco de Quito, Municipalidad de Independencia, Independencia, Santiago. Supported and organized by the FONDAP Center for Chronic Diseases (ACCDiS).

August 23rd- November 18th, 2017. Scientific monitor for High School students in the “Days of Scientific Initiation for High School Students of Municipal Schools of the Independencia Commune focused on Cardiovascular Diseases and Cancer”. Supported and organized by the FONDAP Center for Chronic Diseases (ACCDiS).

October 4th and 17th, 2016. Participation in the Week of Science with two talks intended to High School Students in San Bernardo, Chile. Talk Title: "Cell Therapies". Schools: Kings School (October 4th) and American Academy (October 17th). Organized by EXPLORA Initiative, CONICYT, Chile.

October 5th, 2016. Coordinator and Roundtable Speaker in the Center (CEMC) for Molecular Studies of the Cell - EXPLORA Activity 2016. Organized by the Center CEMC and the Adnaced FONDAP Center for Chronic Diseases (ACCDiS), University of Chile. Visit to the facilities of the different Laboratories of the CEMC and ACCDiS Centers by High School Students from different districts of Santiago in October of 2016.

2015, Volunteer and Judge for the Spring Leadership Conference. Organizada por Health Occupations Students of America (HOSA). Irving, Texas.

2015, Volunteer and Judge for the Dallas ISD’S Stem Divisional Science Fair. Organizada por el Dallas Independent
School District. Dallas, Texas.


Premios y Distinciones

  •   Medalla Hermann Niemeyer

    SOCIEDAD DE BIOQUIMICA DE CHILE

    Chile, 2011

    Distinción para el mejor estudiante de doctorado en Bioquímica o ciencias afines en Chile.

  •   Premio Oriana Josseau

    Fundación Oriana Josseau

    Chile, 2011

    Distinción a la mejor estudiante mujer del programa de Doctorado en Bioquímica.

  •   Beca For Women in Science

    L´Oréal Chile y UNESCO

    Chile, 2009

    En Chile, For Women in Science constituye uno de los premios más destacados de la ciencia a nivel mundial, que L'Oréal junto a UNESCO otorgan en nuestro país. Tiene como misión, reconocer la vocación científica femenina en Chile, galardonando a jóvenes que lo han recibido desde diversas áreas de la ciencia; como física, química, biología, enfermería, geología, ciencias forestales, biotecnología y ecología, entre otras.

  •   IUBMB-SBBq Young Scientists Program (YSP) Fellowship Awardee

    IUBMB and Brazilian Society for Biochemistry and Molecular Biology (SBBq), Brasil.

    Brasil, 2015

    The International Union of Biochemistry and Molecular Biology (IUBMB) and the Brazilian Society for Biochemistry and Molecular Biology (SBBq) jointly hosted the 23rd IUBMB and 44th SBBq Congress in Brazil, August 24-28, 2015. The venue for this conference was the city of Foz do Iguaçu. As part of the IUBMB activities, a satellite IUBMB-SBBq Young Scientists Program (YSP) was held in São Paulo, Brazil, August 20th to 22th, 2015. This program, aimed toward students and recent PhDs, provided a unique opportunity for young scientists from different countries to discuss their scientific results, novel ideas, and career development. Participants in the YSP were selected from candidates worldwide and received fellowships to attend both the YSP and the IUBMB-SBBq Congress.

  •   Beca Fundación Andes para pasantías en centros internacionales de alta tecnología (Programa C-13840).

    Fundación Andes

    Chile, 2002

    Programa de pasantías en centros internacionales de alta tecnología (Programa C-13840) para estudiantes destacados de pregrado. Supervisor Internacional: Dr. Ole H. Petersen FRS, MRC Research Professor. Laboratorio de Fisiología, Departamento de Fisiología, Universidad de Liverpool, Liverpool, Inglaterra.

  •   Premio Adelina Gutierrez, para científicas jóvenes destacadas.

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2019

    El Premio de Excelencia Científica “Adelina Gutiérrez”, es otorgado anualmente por la Academia Chilena de Ciencias (AC), a investigadoras menores de 40 años de edad, con el objetivo de contribuir a la promoción de la Ciencia en el país e incentivar a las investigadoras en Ciencias.


Tipos de Producción
 

Dtp Import/Article (33)

BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism.
Endolysosomal two-pore channels regulate autophagy in cardiomyocytes.
HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor.
Mitochondrial dynamics, mitophagy and cardiovascular disease.
Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy.
FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes.
Alteration in mitochondrial Ca(2+) uptake disrupts insulin signaling in hypertrophic cardiomyocytes.
Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.
Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance.
Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury.
Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway.
Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway.
Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake.
Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes.
Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death.
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration.
A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway.
Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics.
Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy.
[Mitochondrial dynamics: a potential new therapeutic target for heart failure].
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress.
The complex interplay between mitochondrial dynamics and cardiac metabolism.
An inositol 1,4,5-triphosphate (IP3)-IP3 receptor pathway is required for insulin-stimulated glucose transporter 4 translocation and glucose uptake in cardiomyocytes.
Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes.
Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide.
Mitochondria fine-tune the slow Ca(2+) transients induced by electrical stimulation of skeletal myotubes.
Parallel activation of Ca(2+)-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress.
Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species.
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis.
Autofagia del cardiomiocito: ¿un nuevo mecanismo de adaptación al estrés o de muerte celular?
Hyperosmotic stress activates p65/RelB NFkappaB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death.
IGF-1: un factor de crecimiento con acciones cardiovasculares pleiotrópicas
Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes.

Grant (12)

Anillo de Investigación en Ciencia y Tecnología 2017. Mechanisms of Autophagy in Obesity.
Centro FONDAP de Estudios Avanzados de Enfermedades Crónicas / ACCDiS Advanced Center for Chronic Diseases
U-Redes Generación VID 2018. Network for the study of high- lethality cardiopulmonary diseases (REECPAL)

Article (10)

Polycystin-2 Is Required for Starvation- and Rapamycin-Induced Atrophy in Myotubes
Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase of ER stress
Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network
Polycystin-2-dependent control of cardiomyocyte autophagy
Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis
The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content
Calcineurin signaling in the heart: The importance of time and place
Calcium Transport and Signaling in Mitochondria
Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells
mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling

Abstract (2)

MITOCHONDRIA MODULATE INTRACELLULAR CALCIUM SIGNALS THAT CONTROL ATP TRANSIENTS INDUCED BY ELECTRICAL STIMULATION OF SKELETAL MYOTUBES
24
Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Roberto Bravo

Investigador Postdoctoral

Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile

Santiago, Chile

2
Zully Pedrozo

Assistant professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

1
Verónica Eisner

Assistant Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

1
Paula Díaz

POSTDOCTORAL RESEARCH FELLOW

UNIVERSIDAD DE CHILE

Chile

1
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile