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ALEJANDRO HERNAN CORVALAN RODRIGUEZ

Principal Investigator

Pontificia Universidad Catolica de Chile

Santiago, Chile

A full-time medical researcher at Pontificia Universidad Catolica de Chile, involved in translational cancer research at basic, clinical, and population levels. My research focused on cancer epigenetics, systems biology, and biomarker development.

Medical Doctor, EDUCATIONAL COMMISION FOR FOREIGN MEDICAL GRADUATES. Estados Unidos, 1989
Medical Doctor, UNIVERSIDAD DE CHILE. Chile, 1985
Cell Biology, UNIVERSIDAD DE CHILE. Chile, 2006

Full Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Santiago, Chile

2003 - A la fecha
Assistant Professor Full Time

UNIV TEXAS M.D. ANDERSON CANCER CENTER

Houston, TX, Estados Unidos

2007 - 2009

Director Molecular Biology Laboratory Part Time

Clinica Las Condes

Santiago, Chile

1997 - 2003
CSO Part Time

Ilico Genetics

Santiago, Chile

2021 - A la fecha

1. Ossandon F., Uso de Bioinformática como herramienta de análisis de datos en Cáncer Gástrico, in Carrera de Bioquimica, Escuela de Ciencias Quimicas y Farmaceuticas. 2006, Universidad de Chile, Santiago.
2. Alvarez H., Estudio multietnico de la patogenesis del cancer de vesicula biliar, in Programa Doctorado en Ciencias Medicas. 2008, Pontificia Universidad Catolica de Chile, Santiago.
3. Gonzalez P., Inactivación epigenética de genes supresores de tumores como potencial marcador de riesgo de diseminación en cáncer de mama, in Carrera de Bioquímica, Facultad de Ciencias Biológicas. 2009, Pontificia Universidad Catolica de Chile, Santiago.
4. Villarroel C., Reprimo en checkpoint g2/m y su posible rol como biomarcador en cancer gastrico., in Carrera de Bioquímica, Facultad de Ciencias Biológicas. 2009, Pontificia Universidad Catolica.de Chile, Santiago.
5. Buchegger K., Efecto de la modulacion de la expresion de Reprimo sobre el comportamiento celular tumoral in vitro en cancer de mama, in Programa Doctorado en Biología Molecular Aplicada. 2011, Universidad de la Frontera, Temuco.
6. Droguett R., Caracterización in silico de microARNs asociados al gen RPRM mediante herramienta bioinformática, in Escuela de Ingeniería en Bioinformática, Facultad de Ingeniería. 2011, Universidad de Talca, Talca.
7. Saavedra K., Reprimo como potencial Gen Supresor de Tumores en Cáncer Gástrico, evaluación in vitro, in Programa Doctorado en Biología Molecular Aplicada. 2011, Universidad de la Frontera, Temuco.
8. Sandoval A., Rol de miR-335 y miR-597 en la pérdida de función del gen Reprimo en un modelo in vitro de cáncer gástrico, in Programa Doctorado en Biología Molecular Aplicada. 2011, Universidad de la Frontera, Temuco.
9. Garcia B., El Aumento de la expresio n endo gena de Reprimo inducido por un factor de transcripcio n artificial modifica la capacidad tumorige nica de Ca ncer Ga strico in vitro e in vivo, in Programa Doctorado en Ciencias Medicas. 2012, Pontificia Universidad Catolica de Chile, Santiago.
10. Torres V., Regulación de la expresión del gen Reprimo por metilación y su posible rol como gen supresor tumoral en cáncer gástrico, in Carrera de Bioquímica, Escuela de Química. 2012, Pontificia Universidad Catolica de Valparaiso, Valparaiso.
11. Sanchez M., La inactivación del gen Reprimo por metilación de su región promotora es un evento preneoplásico y su detección cuantitativa en plasma permite la deteccion precoz de cáncer gástrico, in Carrera de Bioquímica, Escuela de Química. 2013, Pontificia Universidad Catolica Valparaiso, Valparaiso.
12. Fry, Jacqueline, Hipermetilación aberrante y pérdida de expresión de reprimo en lesiones precursoras de cáncer gástrico, Magíster/Master/DEA, 2015, Universidad Andres Bello, Santiago
13.Pino, Camila, Rol de DNp73 en el riesgo de progresión en lesiones precursoras de Carcinoma Gástrico, Licenciatura/Bachillerato/Bachelor, 2015, Universidad Andres Bello, Santiago
14. Cerda, Paulina, Regulación de Reprimo por Survivina, a través de p53 en Cáncer Gástrico, Magíster/Master/DEA, 2016, Universidad de Chile, Santiago
15. Parra, Nicole, Expresion de proteina RPRM y detection de Helicobater pylori por inmunohistoqumica en muestras de mucosa gastrica caracterizadas por el sistema OLGA y OLGIM, Licenciatura/Bachillerato/Bachelor, 2016, Universidad Andres Bello, Santiago
16. Aranda, Estrella; Ibanez, Natalia, Lesiones preneoplasicas de cancer gastrico albergan cambios de expresion de RPRM, Licenciatura/Bachillerato/Bachelor, 2018, Universidad Andres Bello, Santiago
17. Arriagada, Diego, Interacción funcional entre la oncoproteína EBNA-1 del Virus Epstein-Barr (VEB) y componentes del humo de cigarrillo en células epiteliales gástricas, Magíster/Master/DEA, 2018, Universidad Andres Bello, Santiago
18.Valdivia, Andres, Vasculogenic Mimicry, Programa Doctorado en Ciencias Biologicas, 2019, Pontificia Universidad Catolica de Chile, Santiago.
19. Alarcon, Maria Alejandra. Rol de Reprimo-like en cancer gastrico. Programa Doctorado en Ciencias Medicas. 2020, Pontificia Universidad Catolica de Chile, Santiago.
20. Wichmann, Ignacio. Identification of long noncoding RNAs in competing endogenous RNA networks throughout the gastric precancerous cascade. Programa Doctorado en Ciencias Medicas 2020, Pontificia Universidad Catolica de Chile, Santiago.

PATENTS
1. Corvalán A.H., Método de detección precoz de cáncer gástrico que comprende detectar la presencia de marcadores específicos de cáncer gástrico en muestras de plasma. INAPI, Chile. WO 2011/035453 A2, PCT/CL2010/000041
2. Corvalán A.H.; Kogan, M.; Guzman, L.; Guerrero, A.; Marchant, MJ. “Método ultrasensible de detección de biomarcador de cáncer gástrico reprimo” INAPI-1649-2016
3. Corvalán A.H.; Maturana, MJ.; Santibanez, E. “Method and assay for the non-invasive detection of early gastric cancer by the combined use of methylated reprimo-cell free DNA and pepsinogens I/II. WO/2015/181804
4. Corvalán A.H.; Sandoval A. Método no invasivo de diagnóstico temprano de cáncer gástrico, usando como biomarcador los niveles de metilación de la secuencia de ADN del promotor del microRNA-335. INAPI-Chile
5. Corvalán A.H.; Alarcon, MA. Detección no-invasiva del cancer gastrico a traves de la deteccion en sangre de la metilacion de reprimo-like, PCT/CL2018/050047
6. Corvalán A.H.; Olivares W.; Santoro, P. KCNQ1OT1, un nuevo biomarcador en plasma para deteccion noinvasiva del Cáncer Gástrico (CG) PCT/CL2018/050126

CONFERENCES
1. VIII International Symposium on Helicobacter Pylori and Gastric Cancer, Pepsinogens and gastric atrophy in latin american populations, 2018, Brasil
2. VIII International Symposium on Helicobacter Pylori and Gastric Cancer,Reprimo-like a newly identified Reprimo paralogue gene, is downregulates by DNA methylation in early gastric cancer, 2018, Brasil
3. VIII International Symposium on Helicobacter Pylori and Gastric Cancer, Reprimo expression in gastric cancer and OLGA and OLGIM stages, 2018, Brasil
4. VIII International Symposium on Helicobacter Pylori and Gastric Cancer, A longitudinal study of cell-free DNA of reprimo methylated, pepsinogens and helicobacter pylori in plasma as a non-invasive risk-assessment for OLGA staging, 2018, Brasil
5. VIII International Symposium on Helicobacter Pylori and Gastric Cancer, Immunodetection of pepsinogens, gastrin-17 and helicobacter pylori for non-invasive diagnosis of high-risk atrophic gastritis in chile, 2018, Brasil
6. The International Society for Extracellular Vesicles, Role of microRNA-335-5p in gastric cancer derived extracellular, España, 2018
7. Digestive Disease Week, Helicobacter pylori infection is associated with an increased expression of delta-NP73 in gastric tissue samples from asymptomatic donors, USA, 2018
8. The International Society for Extracellular Vesicles, A simple method to label vesicles for visualization and in vivo tracking, España, 2018
9. AACR annual meeting, The Chilean Gastric Cancer Task Force: An uptade of results, USA, 2018
10. Second AACR international conference translational cancer medicine. Cancer discoveries for clinical application, Molecular characterization of gastric adenocarcinoma tumors from chilean patients, Brasil, 2018
11. XXIX reunion anual sociedad de reproduccion y desarrollo, Vasculogenic mimicry: an alternative model of tumor irrigation in ovarian cancer, Chile, 2018
12. XXXII reunion anual sociedad de biologia celular, Reprimo (RPRM) is involved in epithelial-mesenchymal transition (EMT) in zebrafish embryos, Chile, 2018
13. XLI Reunión Anual de la Sociedad de Bioquímica y Biología Molecular, Gastric cancer derived extracellular vesicles loaded with microRNA-335-5p and their role in tumor development, Chile, 2018
14. XLI Reunión Anual de la Sociedad de Bioquímica y Biología Molecular, Exosomal miRNAs in Gastric Cancer. , Chile, 2018
15. 13th International Gastric Cancer Congress, Reprimo-Like: a potential tumor suppressor and biomarker in gastric cancer, Praga, 2019
16. 50 Digestive Disease Week, mir-597p is associated with tumor invasion and metastasis in gastric cancer, USA, 2019
17. 50 Digestive Disease Week, Reprimo-Like: a potential tumor supressor and biomarker in gastric cancer, USA, 2019
18. AACR annual meeting 2019, The chilean Gastric Cancer Task Force: Final Report, USA, 2019
19. AACR annual meeting 2019, Extracellular signaling linked to PI3K-AKT triggers the formation of vasculogenic mimicry in ovarian cancer, USA, 2019
20. XLII Reunión Anual de la Sociedad de Bioquímica y Biología Molecular, Reduced Angiotensin II Type 2 Receptor expression is associated with gastric
cancer progression and receptor activation reduces gastric cancer cell migration, Chile, 2019
21. AACR, Clinical, biological and translational significance of reprimo-like gene, an uncharacterized member of the reprimo gene family, Virtual annual meeting, 2020
22. AACR, An additive effect of ebv-miR-BART5-5p and hsa-miR18a-5p in the downregulation of CDH1 transcript in Epstein-Barr virus associated gastric cancer, Virtual annual meeting, 2020
23. AACR, Loss of expression of wild-type transcript of CDH1 gene is associated with overexpression of microRNA-20 in diffuse-type of gastric cancer, Virtual annual meeting, 2020
24. LIII Reunion Anual Sociedad Genética de Chile, Identificación de polimorfismos genéticos desde el genoma completo, asociados al patrón de crecimiento de la tasa de mortalidad por infección de Sars-Cov-2, entre diferentes poblaciones, Virtual annual meeting, 2020
25. Cancer Simposium, A clinical platform for cancer research, Virtual annual meeting, 2020
26. Cancer Simposium, Epigenomic landscapes in gastric cancer, Virtual annual meeting, 2020
27. Gastric Cancer Summit - Stanford University, 2020.

OUTREACH
1. II Simposio internacional de bioinformatica integrativa, Organizacion, Chile, 2018
2. IIInternational Symposium on Integrative Bioinformatics, Organizacion, Chile, 2019
3. Laboratorios Itinerantes, Llevar la ciencia a estudiantes de enseñanza básica, Chile, 2019
4. ¿Qué tan cerca está la ciencia de encontrar una cura para el cáncer?, Artículo en prensa, Chile, 2019
5. Encuentro Virtual ACCDiS, Organizacion, Chile, 2020
6. Oncologia Biomedica, Curso para alumons de Doctorado, Chile, 2020
7. Las listas de espera para endoscopia para detectar cáncer gástrico y lesiones precursoras o premalignas, Programa de Radio, Chile, 2020

NETWORK
1. Dr. Luis Carvajal, UC Davis, CA, USA
2. Dr. Wael-ElRifai, U de Miami, FL, USA
3. Dra. Constanza Camargo, NIH, MD, USA
4. Dr. Elmer Fernandez, U. Católica de Cordova, Cordoba, Argentina
5. Dra. Marcis Leja, U. Latvia, Latvia

AVONNI en Salud

FORO INNOVACION

Chile, 2011

2001 award for the discovery of a potential biomarker for early detection of gastric cancer in plasma.
Premio Academia Medicina

ACADEMIA CHILENA DE MEDICINA

Chile, 2014

Premio en reconocimiento a la trayectoria personal, y a la labor multidisciplinaria que realizada en Chile en Cancer Gastrico. Este premio fue compartido con la Dra. Catterina Ferreccio.
Oncologo del Año

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 2017

Premio a la trayectoria, entregado por la Fundación Chilena para el Desarrollo de la Oncología, en conjunto con Comité Organizador del Congreso Latinoamericano de Oncología, SLAGO 2017, por la labor en el desarrollo de la oncología en Chile, contribuyendo al perfeccionamiento en investigación, docencia y en difusión del conocimiento científico”.


Extracellular vesicles from gastric epithelial GES-1 cells infected with Helicobacter pylori promote changes in recipient cells associated with malignancy Fernanda Gonzalez, Maria; Burgos-Ravanal, Renato; Shao, Baohai; Heinecke, Jay; Valenzuela-Valderrama, Manuel; Corvalan, Alejandro H.; Quest, Andrew F. G. Article ISI FRONTIERS IN ONCOLOGY (2022)
A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict clinically relevant toxicity associated with fluoropyrimidine and platinum-based chemotherapy in gastric cancer Cordova-Delgado, Miguel; Loreto Bravo, Maria; Cumsille, Elisa; Hill, Charlotte N.; Munoz-Medel, Matias; Pinto, Mauricio P.; Retamal, Ignacio N.; Lavanderos, Maria A.; Francisco Miquel, Juan; Rodriguez-Fernandez, Maria; Liao, Yuwei; Li, Zhiguang; Corvalan, Alejandro H.; Armisen, Ricardo; Garrido, Marcelo; Quinones, Luis A.; Owen, Gareth, I Article ISI BMC CANCER (2021)
EBV miR-BARTs and human lncRNAs: Shifting the balance in competing endogenous RNA networks in EBV-associated gastric cancer Torres, Keila; Landeros, Natalia; Wichmann, Ignacio A.; Polakovicova, Iva; Aguayo, Francisco; Corvalan, Alejandro H. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)
High-Risk Human Papillomavirus and Epstein-Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis Blanco, Rances; Carrillo-Beltran, Diego; Corvalan, Alejandro H.; Aguayo, Francisco Article ISI BIOLOGY-BASEL (2021)
Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent? Blanco, Rances; Carrillo-Beltran, Diego; Munoz, Juan P.; Corvalan, Alejandro H.; Calaf, Gloria M.; Aguayo, Francisco Article ISI BIOLOGY-BASEL (2021)
Interplay between Epstein-Barr virus infection and environmental xenobiotic exposure in cancer Aguayo, Francisco; Boccardo, Enrique; Corvalan, Alejandro; Calaf, Gloria M.; Blanco, Rances Article ISI INFECTIOUS AGENTS AND CANCER (2021)
Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis Perez-Dominguez, Francisco; Carrillo-Beltran, Diego; Blanco, Rances; Munoz, Juan P.; Leon-Cruz, Grettell; Corvalan, Alejandro H.; Urzua, Ulises; Calaf, Gloria M.; Aguayo, Francisco Article ISI BIOLOGY-BASEL (2021)
A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability Pinto, Mauricio P.; Cordova-Delgado, Miguel; Retamal, Ignacio N.; Munoz-Medel, Matias; Loreto Bravo, M.; Duran, Doris; Villanueva, Francisco; Sanchez, Cesar; Acevedo, Francisco; Mondaca, Sebastian; Koch, Erica; Ibanez, Carolina; Galindo, Hector; Madrid, Jorge; Nervi, Bruno; Pena, Jose; Torres, Javiera; Owen, Gareth, I; Corvalan, Alejandro H.; Armisen, Ricardo; Garrido, Marcelo Article ISI CANCERS (2020)
Angiotensin-(1–9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA pathway Sotomayor-Flores C.; Rivera-MejÃas P.; VÃ¡squez-Trincado C.; LÃ³pez-Crisosto C.; Morales P.E.; Pennanen C.; Polakovicova I.; Aliaga-Tobar V.; GarcÃa L.; Roa, J.C; Rothermel B.A.; Maracaja-Coutinho V.; Ho-Xuan H.; Meister G.; Chiong M.; Ocaranza M.P.; CorvalÃ¡n A.H.; Parra V.; Lavandero S. Article ISI SCOPUS Cell Death and Differentiation (2020)
Cohort Profile: The Maule Cohort (MAUCO) Ferreccio, Catterina; Huidobro, Andrea; Cortes, Sandra; Bambs, Claudia; Toro, Pablo; Van De Wyngard, Vanessa; Acevedo, Johanna; Paredes, Fabio; Venegas, Pia; Verdejo, Hugo; Oyarzun-Gonzalez, Ximena; Cook, Paz; Castro, Pablo F.; Foerster, Claudia; Vargas, Claudio; Koshiol, Jill; Carlos Araya, Juan; Cruz, Francisco; Corvalan, Alejandro H.; Quest, Andrew F.; Kogan, Marcelo J.; Lavandero, Sergio; MAUCO Study Grp Article ISI INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2020)
Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer Landeros, Natalia; Santoro, Pablo; Carrasco-Avino, Gonzalo; Corvalán, Alejandro Article ISI CANCERS (2020)
Effects of preparation on catalytic, magnetic and hybrid micromotors on their functional features and application in gastric cancer biomarker detection BÃ¡ez D.F.; Ramos G.; CorvalÃ¡n A.; Cordero M.L.; Bollo S.; Kogan M.J. Article ISI SCOPUS (2020)
Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors Lara, Pablo; Palma-Florez, Sujey; Salas-Huenuleo, Edison; Polakovicova, Iva; Guerrero, Simon; Lobos-Gonzalez, Lorena; Campos, America; Munoz, Luis; Jorquera-Cordero, Carla; Varas-Godoy, Manuel; Cancino, Jorge; Arias, Eloisa; Villegas, Jaime; Cruz, Luis J.; Albericio, Fernando; Araya, Eyleen; Corvalan, Alejandro H.; Quest, Andrew F. G.; Kogan, Marcelo J. Article ISI SCOPUS JOURNAL OF NANOBIOTECHNOLOGY (2020)
Human Papillomavirus 16 E7 Promotes EGFR/PI3K/AKT1/NRF2 Signaling Pathway Contributing to PIR/NF-kappa B Activation in Oral Cancer Cells Carrillo-Beltran, Diego; Munoz, Juan P.; Guerrero-Vasquez, Nahir; Blanco, Rances; Leon, Oscar; de Souza Lino, Vanesca; Tapia, Julio C.; Maldonado, Edio; Dubois-Camacho, Karen; Hermoso, Marcela A.; Corvalan, Alejandro H.; Calaf, Gloria M.; Boccardo, Enrique; Aguayo, Francisco Article ISI CANCERS (2020)
In vitro evaluation and molecular docking of QS-21 and quillaic acid from Quillaja saponaria Molina as gastric cancer agents Guzman, Leda; Villalon, Katherine; Jose Marchant, Maria; Elena Tarnok, Maria; Cardenas, Pilar; Aquea, Gisela; Acevedo, Waldo; Padilla, Leandro; Bernal, Giuliano; Molinari, Aurora; Corvalan, Alejandro Article ISI SCIENTIFIC REPORTS (2020)
The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer Alejandra Alarcon, Maria; Olivares, Wilda; Cordova-Delgado, Miguel; Munoz-Medel, Matias; de Mayo, Tomas; Carrasco-Avino, Gonzalo; Wichmann, Ignacio; Landeros, Natalia; Amigo, Julio; Norero, Enrique; Villarroel-Espindola, Franz; Riquelme, Arnoldo; Garrido, Marcelo; Owen, Gareth, I; Corvalan, Alejandro H. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
A Novel Role for Helicobacter pylori Gamma-Glutamyltranspeptidase in Regulating Autophagy and Bacterial Internalization in Human Gastric Cells Bravo; Díaz; Corvalán; Quest Article ISI SCOPUS CANCERS (2019)
Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers Gomaa A.; Peng D.; Chen Z.; Soutto M.; Abouelezz K.; Corvalan A.; El-Rifai W. Article ISI SCOPUS SCIENTIFIC REPORTS (2019)
Fact or Fiction, It Is Time for a Verdict on Vasculogenic Mimicry? Valdivia A.; Mingo G.; Aldana V.; Pinto, M. P.; Ramirez M.; Retamal C.; Gonzalez A.; Nualart F.; Corvalan A.H.; Owen, G. I. Article ISI SCOPUS FRONTIERS IN ONCOLOGY (2019)
Gold@Silica Nanoparticles Functionalized with Oligonucleotides: A Prominent Tool for the Detection of the Methylated Reprimo Gene in Gastric Cancer by Dynamic Light Scattering Jose Marchant, Maria; Guzman, Leda; Corvalan, Alejandro H.; Kogan, Marcelo J. Article ISI SCOPUS Nanomaterials (2019)
High Proportion of Potential Candidates for Immunotherapy in a Chilean Cohort of Gastric Cancer Patients: Results of the FORCE1 Study Cordova-Delgado, Miguel; Pinto, Mauricio P.; Retamal, Ignacio N.; Munoz-Medel, Matias; Loreto Bravo, Maria; Fernandez, Maria F.; Cisternas, Betzabe; Mondaca, Sebastian; Sanchez, Cesar; Galindo, Hector; Nervi, Bruno; Ibanez, Carolina; Acevedo, Francisco; Madrid, Jorge; Pena, Jose; Koch, Erica; Jose Maturana, Maria; Romero, Diego; de la Jara, Nathaly; Torres, Javiera; Espinoza, Manuel; Balmaceda, Carlos; Liao, Yuwei; Li, Zhiguang; Freire, Matias; Garate-Calderon, Valentina; Caceres, Javier; Sepulveda-Hermosilla, Gonzalo; Lizana, Rodrigo; Ramos, Liliana; Artigas, Rocio; Norero, Enrique; Crovari, Fernando; Armisen, Ricardo; Corvalan, Alejandro H.; Owen, Gareth, I; Garrido, Marcelo Article ISI SCOPUS CANCERS (2019)
Identification of c.1531C>T Pathogenic Variant in the CDH1 Gene as a Novel Germline Mutation of Hereditary Diffuse Gastric Cancer Norero E.; Alarcon M.A.; Hakkaart C.; de Mayo T.; Mellado C.; Garrido M.; Aguayo G.; Lagos M.; Torres J.; Calvo A.; Guilford P.; Corvalan A.H. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Integrated Analysis of Mouse and Human Gastric Neoplasms Identifies Conserved microRNA Networks in Gastric Carcinogenesis Chen, Z; Li, Z; Soutto, M; Wang, WZ; Piazuelo, MB; Zhu, SM; Guo, Y; Maturana MJ; Corvalan, AH; Chen, X; Xu, ZK; El-Rifai, WM Article ISI SCOPUS GASTROENTEROLOGY (2019)
The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish Stanic, Karen; Reig, German; Wichmann, Ignacio A.; Opazo, Juan C.; Owen, Gareth, I; Corvalan, Alejandro H.; Concha, Miguel L.; Amigo, Julio D. Article ISI SCOPUS SCIENTIFIC REPORTS (2019)
[Cardiotoxicity of anticancer therapies. Towards the implementation of cardio-oncology units]. Hameau, René; Gabrielli, Luigi; Garrido, Marcelo; Guzmán, Ana María; Retamal, Ignacio; Vacarezza, María José; Greig, Douglas; Ocqueteau, Mauricio; Sánchez, César; Pizarro, Marcela; Corvalán, Alejandro; Lavandero, Sergio; Castro, Pablo F; Martínez, Gonzalo Article Revista medica de Chile (2018)
Chilean Gastric Cancer Task Force=> A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients. Owen, Gareth I; Pinto, Mauricio P; Retamal, Ignacio N; Fernádez, María F; Cisternas, Betzabe; Mondaca, Sebastian; Sanchez, Cesar; Galindo, Hector; Nervi, Bruno; Ibañez, Carolina; Acevedo, Francisco; Madrid, Jorge; Peña, José; Bravo, Maria Loreto; Maturana, Maria Jose; Cordova-Delgado, Miguel; Romero, Diego; de la Jara, Nathaly; Torres, Javiera; Rodriguez-Fernandez, Maria; Espinoza, Manuel; Balmaceda, Carlos; Freire, Matías; Gárate-Calderón, Valentina; Crovari, Fernando; Jimenez-Fonseca, Paula; Carmona-Bayonas, Alberto; Zwenger, Ariel; Armisen, Ricardo; Corvalan, Alejandro H; Garrido, Marcelo Article Medicine (2018)
Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis? Urra, Soledad; Fischer, Martin C; Martínez, José R; Véliz, Loreto; Orellana, Paulina; Solar, Antonieta; Bohmwald, Karen; Kalergis, Alexis; Riedel, Claudia; Corvalán, Alejandro H; Roa, Juan C; Fuentealba, Rodrigo; Cáceres, C Joaquin; López-Lastra, Marcelo; León, Augusto; Droppelmann, Nicolás; González, Hernán E Article Oncotarget (2018)
Expression of RPRM/rprm in the Olfactory System of Embryonic Zebrafish (Danio rerio). Stanic K, Quiroz A; Lemus CG, Wichmann IA; Corvalán AH, Owen GI; Opazo JC, Concha ML Article FRONTIERS IN NEUROANATOMY (2018)
Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer. Cerda-Opazo P, Valenzuela-Valderrama M; Wichmann I, Rodríguez A; Contreras-Reyes D, Fernández EA; Carrasco-Aviño G, Corvalán AH Article ONCOTARGET (2018)
Role of microRNAs and Exosomes in and Epstein-Barr Virus Associated Gastric Cancers Polakovicova I, Jerez S; Wichmann IA, Sandoval-Bórquez A; Carrasco-Véliz N, Corvalán AH Article FRONTIERS IN MICROBIOLOGY (2018)
The Reprimo Gene Family=> A Novel Gene Lineage in Gastric Cancer with Tumor Suppressive Properties. Amigo, Julio D; Opazo, Juan C; Jorquera, Roddy; Wichmann, Ignacio A; Garcia-Bloj, Benjamin A; Alarcon, Maria Alejandra; Owen, Gareth I; Corvalán, Alejandro H Article International journal of molecular sciences (2018)
Expression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer. Graumann, Rebecca; Di Capua, Gabriella A; Oyarzún, Juan E; Vásquez, Marcos A; Liao, Christine; Brañes, Jorge A; Roa, Iván; Casanello, Paola; Corvalán, Alejandro H; Owen, Gareth I; Delgado, Iris; Zangemeister-Wittke, Uwe; Ziegler, Annemarie Article PloS one (2017)
Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer. Sahasrabudhe R, Lott P; Bohorquez M, Toal T; Estrada AP, Suarez JJ; Brea-Fernández A, Cameselle-Teijeiro J; Pinto C, Ramos I; Mantilla A, Prieto R; Corvalan A, Norero E; Alvarez C, Tapia T; Carvallo P, Gonzalez LM; Cock-Rada A, Solano A; Neffa F, Della Va; Latin American Gastric Cancer Genetics Collaborative Group, Taylor PR; Goldstein AM, Torres J; Echeverry M, Ruiz-Ponte C; Teixeira MR, Carvajal-Carmona LG Article GASTROENTEROLOGY (2017)
MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer Sandoval-Bórquez A, Polakovicova I; Carrasco-Véliz N, Lobos-González L; Riquelme I, Carrasco-Avino G; Bizama C, Norero E; Owen GI, Roa JC Article CLINICAL EPIGENETICS (2017)
Reprimo tissue-specific expression pattern is conserved between zebrafish and human. Figueroa, Ricardo J; Carrasco-Avino, Gonzalo; Wichmann, Ignacio A; Lange, Martin; Owen, Gareth I; Siekmann, Arndt F; Corvalán, Alejandro H; Opazo, Juan C; Amigo, Julio D Article PloS one (2017)
Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer Weber, H; Valbuena, JR; Barbhuiya, MA; Stein, S; Kunkel, H; García, P; Bizama, C; Riquelme, I; Espinoza, JA; Kurtz, SE; Tyner, J; Calderon, JF; Corvalán, AH; Grez, M; Pandey, A; Leal-Rojas, P; Roa, JC Article Oncotarget (2017)
The conundrum of the Epstein-Barr virus-associated gastric carcinoma in the Americas Carrasco-Avino G=> Riquelme I, Padilla O; Villaseca M, Aguayo FR Article ONCOTARGET (2017)
Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells Carrillo D, Muñoz JP; Huerta H, Leal G; Corvalán A, León O; Calaf GM, Urzúa U; Boccardo E, Tapia JC Article OPEN BIOLOGY (2017)
Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival Alvarez C.; Aravena, A.; Tapia, T.; Rozenblum E.; Solís L.; Corvalan, A; Camus, M; Alvarez M.; Munroe D.; Maass A.; Carvallo, P. Article ISI SCOPUS BMC Cancer (2016)
Escaping Antiangiogenic Therapy=> Strategies Employed by Cancer Cells. Pinto, Mauricio P; Sotomayor, Paula; Carrasco-Avino, Gonzalo; Corvalan, Alejandro H; Owen, Gareth I Article International journal of molecular sciences (2016)
Evolutionary history of the reprimo tumor suppressor gene family in vertebrates with a description of a new reprimo gene lineage. Wichmann, Ignacio A; Zavala, Kattina; Hoffmann, Federico G; Vandewege, Michael W; Corvalán, Alejandro H; Amigo, Julio D; Owen, Gareth I; Opazo, Juan C Article Gene (2016)
Gastric Cancer=> Nanoparticles as Tools to Improve Treatment Efficacy. Guerrero, Ariel R; Oyarzun-Ampuero, Felipe; Hassan, Natalia; Corvalán, Alejandro H; Quest, Andrew F G; Kogan, Marcelo J Article Current pharmaceutical design (2016)
Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer Buchegger, K; Lopez, J.; Ili C.; Riquelme I.; Letelier P; Guzman P.; Bellolio E.; Corvalán A.H.; Brebi P.; Roa, J.C Article ISI SCOPUS International Journal of Clinical and Experimental Medicine (2016)
Reprimo as a modulator of cell migration and invasion in the MDA-MB-231 breast cancer cell line. Buchegger, Kurt; Ili, Carmen; Riquelme, Ismael; Letelier, Pablo; Corvalán, Alejandro H; Brebi, Priscilla; Huang, Tim Hui-Ming; Roa, Juan Carlos Article Biological research (2016)
Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024. Ferreccio, Catterina; Roa, Juan Carlos; Bambs, Claudia; Vives, Alejandra; Corvalán, Alejandro H; Cortés, Sandra; Foerster, Claudia; Acevedo, Johanna; Huidobro, Andrea; Passi, Alvaro; Toro, Pablo; Covacevich, Yerko; de la Cruz, Rolando; Koshiol, Jill; Olivares, Mauricio; Miquel, Juan Francisco; Cruz, Francisco; Silva, Raúl; Quest, Andrew F; Kogan, Marcelo J; Castro, Pablo F; Lavandero, Sergio Article BMC public health (2016)
Waking up dormant tumor suppressor genes with zinc fingers, TALEs and the CRISPR/dCas9 system. Garcia-Bloj, Benjamin; Moses, Colette; Sgro, Agustin; Plani-Lam, Janice; Arooj, Mahira; Duffy, Ciara; Thiruvengadam, Shreyas; Sorolla, Anabel; Rashwan, Rabab; Mancera, Ricardo L; Leisewitz, Andrea; Swift-Scanlan, Theresa; Corvalan, Alejandro H; Blancafort, Pilar Article Oncotarget (2016)
A snapshot of cancer in Chile: Analytical frameworks for developing a cancer policy De Jimenez La Jara J.; Bastias G.; Ferreccio C.; Moscoso, C.; Sagues S.; Cid C.; Bronstein E.; Herrera, C; Nervi, B; Corvalan, A; Velasquez E.V.; Gonzalez P.; Castellón E.; Bustamante, E; Oñate S.; McNerney E.; Sullivan R.; Owen, G. I. Article SCOPUS Biological Research (2015)
Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis. Valenzuela, Manuel A; Canales, Jimena; Corvalán, Alejandro H; Quest, Andrew F G Article World journal of gastroenterology (2015)
Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer Saavedra K, Valbuena J; Olivares W, Marchant MJ; Rodríguez A, Torres-Estay V; Carrasco-Avino G, Guzmán L; Aguayo F, Roa JC Article PLOS ONE (2015)
Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer. Saavedra, Kathleen; Valbuena, José; Olivares, Wilda; Marchant, María José; Rodríguez, Andrés; Torres-Estay, Verónica; Carrasco-Avino, Gonzalo; Guzmán, Leda; Aguayo, Francisco; Roa, Juan Carlos; Corvalán, Alejandro H Article PloS one (2015)
NonCoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers Alejandra Sandoval-Bórquez (1,2,3)#a, Katheleen Saavedra (1,2,3)#a, Gonzalo Carrasco (4, 5), Benjamín García (3)#b, Jacqueline Fry (1,3), Ignacio Wichmann (1,3), Alejandro H. Corvalán (1,3,6) Article Disease Markers (2015)
Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer Oyarzun Ampuero, F; Guerrero, A; Hassan-Lopez, N; Morales, JO; Bollo, S; Corvalan, A; Quest, AFG; Kogan, MJ Article ISI CURRENT PHARMACEUTICAL DESIGN (2015)
Tobacco Smoke Activates Human Papillomavirus 16 p97 Promoter and Cooperates with High-Risk E6/E7 for Oxidative DNA Damage in Lung Cells Peña, Nelson; Carrillo, Diego; Muñoz, Juan P.; Chnaiderman, Jonás; Urzúa, Ulises; León, Oscar; Tornesello, Maria L.; Corvalán, Alejandro H.; Soto?Rifo, Ricardo; Aguayo, Francisco; Liu, Xuefeng Article ISI SCOPUS PLOS ONE (2015)
Improved survival of gastric cancer with tumor Epstein-Barr virus positivity: An international pooled analysis Camargo M.C.; Kim W.H.; Chiaravalli A.M.; Kim K.M.; Corvalan A.H.; Matsuo K.; Yu J.; Sung J.J.; Herrera-Goepfert R.; Meneses-Gonzalez F; Kijima Y.; Natsugoe S.; Liao L.M.; Lissowska J.; Kim S.; Hu N.; Gonzalez C.A.; Yatabe Y.; Koriyama C.; Hewitt S.M.; Akiba S.; Gulley M.L.; Taylor P.R.; Rabkin CS Article Gut (2014)
A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients Tang H., et al., Article Clin Cancer Res (2013)
Bases Epigenéticas del Cáncer Gástrico: Oportunidades para la búsqueda de nuevos biomarcadores Corvalán A.H. Article Revista Medica de Chile (2013)
Class-Biased Electoral Participation: The Youth Vote in Chile Corvalan, A; Cox, P Article ISI SCOPUS Latin American Politics and Society (2013)
Functional Interaction between Human Papillomavirus Type 16 E6 and E7 Oncoproteins and Cigarette Smoke Components in Lung Epithelial Cells Munoz, J. P.; González C; Parra, B; Corvalán A.H.; Tornesello M.L.; Eizuru Y.; Aguayo, F. Article ISI SCOPUS PLOS ONE (2012)
Lynch syndrome: selection of families by microsatellite instability and immunohistochemistry Wielandt, AM; Zarate, AJ; Hurtado C.; Orellana P.; Alvarez, K; Pinto, E; Contreras, L. ; Corvalan, A; Kronberg U.; Lopez-Kostner, F Article ISI REVISTA MEDICA DE CHILE (2012)
Merkel cell polyomavirus in non-small cell lung carcinomas from Chile Gheit T.; Munoz, J. P.; Levican J.; González C; Ampuero S.; Parra, B; Gaggero A.; Corvalán A.H.; Meneses M.; Tommasino M.; Aguayo, F. Article ISI SCOPUS Experimental and Molecular Pathology (2012)
Síndrome de Lynch: selección de pacientes para el estudio genético mediante análisis de inestabilidad microsatelital e inmunohistoquímica Wielandt A.M.; Zárate A.J.; Hurtado C.; Orellana P.; Alvarez, K; Pinto, E; Contreras, L. ; Corvalan, A; Kronberg U.; Lopez-Kostner, F Article SCIELO SCOPUS REVISTA MEDICA DE CHILE (2012)
Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis Camargo, MC; Murphy, G; Koriyama C.; Pfeiffer, RM; Kim, WH; Herrera-Goepfert, R; Corvalan, AH; Carrascal, E; Abdirad A.; Anwar M.; Hao Z.; Kattoor J.; Yoshiwara-Wakabayashi E.; Eizuru Y.; Rabkin CS; Akiba S. Article ISI SCOPUS British Journal of Cancer (2011)
High-risk HPV infection after five years in a population-based cohort of Chilean women Ferreccio C.; Van De Wyngard V; Dominguez M.A.; Puschel K.; Corvalán A.H.; Olcay F.; Franceschi S.; Snijders P.J.F. Article ISI SCOPUS Infectious Agents and Cancer (2011)
Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile Aguayo, F.; González C; Ampuero S.; Khan, N; Koriyama C.; Akiba S.; Padilla, O; Solís L.; Eizuru Y.; Corvalan, A Article ISI SCOPUS Infectious Agents and Cancer (2011)
Identification of the distinctive type i/XhoI+ strain of epstein-barr virus in gastric carcinoma in Peru Ordonez P.; Koriyama C.; Ding, S; Akiba S.; Yoshiwara E.; Takano J.; Watanabe, J; Miyagui J.; Corvalán A.H.; Chirinos J.L.; Hidalgo H.; Chacon, P; Linares V.; Eizuru Y. Article SCOPUS Anticancer Research (2011)
Factores de riesgo de alteraciones citológicas del cuello uterino en mujeres chilenas: Un estudio de casos y controles SOLIS, MARÍA TERESA; Aguayo, Francisco; Vargas, Macarena; Olcay, Fabiola; Puschel, Klaus; Corvalán, Alejandro; Ferreccio, Catterina Article SCIELO REVISTA MEDICA DE CHILE (2010)
Helicobacter pylori-Induced Loss of the Inhibitor-of-Apoptosis Protein Survivin Is Linked to Gastritis and Death of Human Gastric Cells Valenzuela,M.; Perez-Perez, G; Corvalan, AH; Carrasco, G; Urra, H; Bravo D.; Toledo, H; Quest, AFG Article ISI SCOPUS Journal of Infectious Diseases (2010)
Human papillomavirus (HPV) genotypes in cervix uterine cancer patients in a public hospital and private clinic from Santiago, Chile Valdivia, IM; Aguayo, F.; Pruyas, M; Snijders, PJF; Corvalan, A; Ferreccio C. Article ISI REVISTA CHILENA DE INFECTOLOGIA (2010)
Overexpression of p73 as a Tissue Marker for High-Risk Gastritis Carrasco, G; Díaz, J; Valbuena, JR; Ibáñez P.; Rodríguez, P.; Araya G.; Rodriguez, C; Torres J.; Duarte, I; Aravena, E; Mena, F.; Barrientos, C.; Corvalan, AH Article ISI SCOPUS Clinical Cancer Research (2010)
Recent patents of DNA methylation biomarkers in gastrointestinal oncology Corvalán A.H.; Maturana M.J. Article SCOPUS Recents patents on DNA & genes sequences (2010)
Risk factors associated with abnormal cervical cytology among Chilean women: A case control study Solis, MT; Aguaya, F; Vargas, M.; Olcay F.; Puschel K.; Corvalan, A; Ferreccio C. Article ISI REVISTA MEDICA DE CHILE (2010)
Risk factors associated with abnormal cervical cytology among Chilean women: A case control study Factores de riesgo de alteraciones citológicas del cuello uterino en mujeres Chilenas: Un estudio de casos y controles Solis M.T.; Ferreccio C.; Aguayo, F.; Vargas, M.; Corvalan, A; Olcay F.; Puschel K. Article SCOPUS Revista Medica de Chile (2010)
Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples Ferreccio C.; Corvalan, A; Margozzini P.; Viviani, P; González C; Aguilera X.; Gravitt, PE Article ISI SCOPUS BMC PUBLIC HEALTH (2008)
DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA 1 promoter region in early-onset gastric carcinogenesis Bernal, C; Vargas, M.; Ossandon F; Santibanez, E; Urrutia, J; Luengo, V; Zavala, LF; Backhouse, C.; Palma M.; Argandoña J.; Aguayo, F.; Corvalan, A Article ISI BIOLOGICAL RESEARCH (2008)
DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis Bernal, Carolina; Vargas, Macarena; Ossandon, Francisco; Santibañez, Eudocia; Urrutia, Julio; Luengo, Victor; ZAVALA, LUIS F; Backhouse, Claudia; Palma, Mariana; Argandona, Jorge; Aguayo, Francisco; Corvalán, Alejandro Article SCIELO SCOPUS BIOLOGICAL RESEARCH (2008)
In Silico analysis of Gastric carcinoma Serial Analysis of Gene Expression libraries reveals different profiles associated with ethnicity Ossandon FJ; villarroel, c; Aguayo, F.; Santibanez, E; Oue, N; Yasui, W; Corvalan, AH Article ISI SCOPUS MOLECULAR CANCER (2008)
Mismatch repair expression in testicular cancer predicts recurrence and survival Velasco, A; Corvalan, A; Wistuba, II; Riquelme E.; Chuaqui, R; Majerson A.; Leach, FS Article ISI SCOPUS INTERNATIONAL JOURNAL OF CANCER (2008)
Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors Tapia, T.; Smalley SV; Kohen P.; MuÑoz A.; Solis, LM; Corvalan, A; Faundez, P; Devoto L.; Camus, M; Alvarez M.; Carvallo, P. Article ISI SCOPUS EPIGENETICS (2008)
Reprimo as a Potential Biomarker for Early Detection in Gastric Cancer Bernal, C; Aguayo, F.; villarroel, c; Vargas, M.; Díaz I.; Ossandon FJ; Santibanez, E; Palma M.; Aravena, E; Barrientos, C.; Corvalan, AH Article ISI SCOPUS CLINICAL CANCER RESEARCH (2008)
Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer Alvarez H.; Corvalan, A; Roa, JC; Argani, P; Murillo F.; Edwards J.; Beaty, R; Feldmann, G; Hong, SM; Mullendore, M; Roa, I; Ibanez, L; Pimente, F; Diaz A.; Riggins, GJ; Maitra A. Article ISI SCOPUS CLINICAL CANCER RESEARCH (2008)
Analytical detection of immunoglobulin heavy chain gene rearrangements in gastric lymphoid infiltrates by peak area analysis of the melting curve in the LightCycler System Retamales E.; Rodríguez L.; Guzman, L; Aguayo, F.; Palma M.; Backhouse, C.; Argandoña J.; Riquelme E.; Corvalan, A Article ISI SCOPUS JOURNAL OF MOLECULAR DIAGNOSTICS (2007)
E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance Koriyama C.; Akiba S.; Itoh, T; Sueyoshi, K; Minakami, Y; Corvalan, A; Yonezawa, S; Eizuru Y. Article ISI SCOPUS WORLD JOURNAL OF GASTROENTEROLOGY (2007)
Epstein-Barr virus-associated primary lymphoepitheliomalike carcinoma of the esophagus Valbuena, JR; Retamal Y.; Bernal, C; Eizuru Y.; Corvalan, A Article ISI SCOPUS DIAGNOSTIC MOLECULAR PATHOLOGY (2007)
Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma Riquelme E.; Tang M.; Baez, S; Diaz A.; Pruyas, M; Wistuba, II; Corvalan, A Article ISI SCOPUS CANCER LETTERS (2007)
Gene expression profiles for therapeutic decisions in breast cancer Corvalan, A Article ISI REVISTA MEDICA DE CHILE (2007)
Gene expression profiles for therapeutic decisions in breast cancer Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama Corvalan, A Article REVISTA MEDICA DE CHILE (2007)
Hierarchical clustering analysis to detect associations between clinical and pathological features of gastric tumors and hypermethylation of suppressor genes Zavala, L; Luengo, V; Ossandon F; Riquelme E.; Backhouse, C.; Palma M.; Argandoña J.; Cumsille, MA; Corvalan, A Article ISI REVISTA MEDICA DE CHILE (2007)
High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile GUZMAN, LEDA M; Koriyama, Chihaya; Akiba, Suminori; Eizuru, Yoshito; Castillo, Darwins; Corvalán, Alejandro; AGUAYO, FRANCISCO R Article SCIELO BIOLOGICAL RESEARCH (2007)
High frequency of p16 promoter methylation in non-small cell lung carcinomas from Chile Guzman, LM; Koriyama C.; Akiba S.; Eizuru Y.; Castillo, D.; Corvalan, A; Aguayo FR Article ISI SCOPUS BIOLOGICAL RESEARCH (2007)
Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile Aguayo, F.; Castillo A.; Koriyama C.; Higashi, M; Itoh, T; Capetillo, M; Shuyama, K; Corvalan, A; Eizuru Y.; Akiba S. Article ISI SCOPUS BRITISH JOURNAL OF CANCER (2007)
Nasal natural killer/T-cell lymphoma and its association with type i"/Xhol loss strain Epstein-Barr virus in Chile" Cabrera, ME.; Eizuru Y.; Itoh, T; Koriyama C.; Tashiro, Y; Ding, S; Rey, S; Akiba S.; Corvalan, A Article ISI SCOPUS JOURNAL OF CLINICAL PATHOLOGY (2007)
Association of a distinctive strain of Epstein-Barr virus with gastric cancer Corvalan, A; Ding, S; Koriyama C.; Carrascal, E; Carrasquilla G.; Backhouse, C.; Urzua, L; Argandoña J.; Palma M.; Eizuru Y.; Akiba S. Article ISI SCOPUS INTERNATIONAL JOURNAL OF CANCER (2006)
Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile Castillo A.; Aguayo, F.; Koriyama C.; Torres M.; Carrascal, E; Corvalan, A; Roblero JP; Naquira, C; Palma M.; Backhouse, C.; Argandoña J.; Itoh, T; Shuyama, K; Eizuru Y.; Akiba S. Article ISI SCOPUS WORLD JOURNAL OF GASTROENTEROLOGY (2006)
Pathogenic role of PTEN tumor suppressor gene in ovarian cancer associated to endometriosis Castiblanco, A; Pires, N; Wistuba, I; Riquelme E.; Andrade L.; Corvalan, A Article ISI REVISTA MEDICA DE CHILE (2006)
Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus Corvalan, A; Akiba S.; Valenzuela, MT; Cumsille, MA; Koriyama C.; Argandoña J.; Backhouse, C.; Bal, M; Mena, F.; Palma M.; Eizuru Y. Article ISI REVISTA MEDICA DE CHILE (2005)
Histology-specific gender, age and tumor-location distributions of Epstein-Barr virus-associated gastric carcinoma in Japan Koriyama C.; Akiba S.; Corvalan, A; Carrascal, E; Itoh, T; Herrera-Goepfert, R; Eizuru Y.; Tokunaga, M Article ISI ONCOLOGY REPORTS (2004)
Prognostic significance of Epstein-Barr virus involvement in gastric carcinoma in Japan Koriyama C.; Akiba S.; Itoh, T; Kijima, Y; Sueyoshi, K; Corvalan, A; Herrera-Goepfert, R; Eizuru Y. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2002)
Epstein-Barr virus in gastric carcinoma is associated with location in the cardia and with a diffuse histology: A study in one area of Chile Corvalan, A; Koriyama C.; Akiba S.; Eizuru Y.; Backhouse, C.; Palma M.; Argandoña J.; Tokunaga, M Article ISI SCOPUS INTERNATIONAL JOURNAL OF CANCER (2001)
Gastric permeability is not increased in children colonized by CagA-positive strains of Helicobacter pylori Gotteland M.; Corvalan, A; Sarmiento F.; Chávez E.; Backouse, C; Palma M.; Kakarieka, E; Vial, MT; Figueroa G. Article ISI SCOPUS DIGESTIVE AND LIVER DISEASE (2001)
Helicobacter pylori: análisis de cagA y genotipificación de vacA en Chile. Detección de una cepa s2/m1 Martínez T, Alejandra; González C, Carlos; Kawaguchi P, Fernando; Montoya, Rolando; Corvalán, Alejandro; Madariaga B, Jaime; Roa S, Jorge; García C, Apolinaria; Salgado, Fernando; Solar, Henry; Palma, Mariana Article SCIELO REVISTA MEDICA DE CHILE (2001)
Helicobacter pylori: cagA status and vacA genotyping in Chile. Detection of a s2/m1 strain Martinez, TA; Gonzalez, CC; Kawaguchi, PF; Montoya R.; Corvalan, A; Madariaga, J; Roa, J; Garcia, CA; Salgado, F; Solar, H; Palma M. Article REVISTA MEDICA DE CHILE (2001)
Helicobacter pylori: caga status and vaca genotyping in Chile. Detection of a s2/m1 strain [Helicobacter pylori: Análisis de caga y genotipificación de vaca en Chile. Detección de una cepa s2/m1] Martinez T A.; Gonzalez C C.; Kawaguchi P F.; Montoya R.; Corvalan, A; Madariaga B J.; Roa S J.; Garcia C A.; Salgado, F; Solar, H; Palma M. Article SCOPUS REVISTA MEDICA DE CHILE (2001)
Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer Carrasco, G; Corvalan, A Article 10.1155/2013/393015 1604-2004: SUPERNOVAE AS COSMOLOGICAL LIGHTHOUSES
Improved survival of gastric cancer with tumor Epstein-Barr virus positivity: An international pooled analysis. Camargo et al. Article 10.1136/gutjnl-2013-304531 Gut


Combined use of methylated reprimo cell-free DNA and pepsinogens for noninvasive detection of early gastric cancer Alarcon, A.; Olivares, W; Maturana MJ; Rodríguez A.; Padilla, O; Wichmann, IA; Calvo, A; Corvalan, A Abstract ISI JOURNAL OF CLINICAL ONCOLOGY (2015)
Could methylated reprimo cell-free DNA serve as a novel tumor marker to assess response in locally advanced gastric cancer treated with preoperative chemotherapy? Muller, BG; Alarcon, A.; Arancibia, JM; Alfaro F.; Sola, JA; Maturana MJ; Ascui, RA; Fernandez, W; Corvalan, A Abstract ISI JOURNAL OF CLINICAL ONCOLOGY (2015)
Identification of Emerging Micro RNA markers for Heart Failure Development Using a Bioinformatic Approach Verdejo, HE; Castro, PF; Artigas R.; Wichmann I.; Corvalan, A Abstract ISI JOURNAL OF HEART AND LUNG TRANSPLANTATION (2015)
Identification of novel upregulated microRNAs in the pathogenesis of gastric cancer by the use of open access databases and bioinformatics tools Wichmann, IA; Artigas R.; Alarcon, A.; Olivares, W; Roldan, N; Fry, J; Cerda, P; Corvalan, A Abstract ISI JOURNAL OF CLINICAL ONCOLOGY (2015)
HSP90 expression and antitumoral activity of geldanamycin and its analog 17-AAG in gallbladder cancer. Valbuena, JR; Roa, JC; Leal, PA; Garcia, PA; Corvalan, A Abstract ISI CANCER RESEARCH (2013)
SCREENING AND TRIAGE TEST FOR EARLY DETECTION OF GASTRIC CANCER (STEAD-GC) Corvalan, A; Calvo, A; Ferreccio C.; Maturana, M; Cook, P; Sánchez, M; Aravena, E; Barrientos, C.; Estela, R Abstract ANNALS OF ONCOLOGY (2012)
Screening and Triage Test for Early Detection of Gastric Cancer (STEAD-GC): A noninvasive trial for early detection of gastric cancer Corvalan, A; Maturana MJ; Sánchez, M; Calvo, A; Ferreccio C. Abstract ISI JOURNAL OF CLINICAL ONCOLOGY (2012)
A Multiple Testing Approach for Histological and Molecular Markers for Early Gastric Cancer Carrasco, G; Ibáñez P.; Valbuena, JR; Mena, F.; Aguayo FR; Ferreccio C.; Corvalan, A Abstract LABORATORY INVESTIGATION (2009)
Inactivation of cell cycle regulatory genes in ovarian cancers Corvalan, A; Rahama, J; Riquelme E.; Wu, H; Dottino, PR; Kalir, T Abstract GYNECOLOGIC ONCOLOGY (2008)
A new epithelial mapping system use cytology prep to detect gallbladder adenocarcinoma on the operative room Alvarez, HA; Zarate, A; Castiblanco, A; Madrid, P; Aguayo, G; Giannini, MJ; Alvarez, MDLA; Duarte, I; Pimentel, F; Ibanez, L; Diaz A.; Corvalan, A Abstract FASEB JOURNAL (2007)
CpG island methylation profile in gastric carcinoma Corvalan, A; Backhouse, C.; Wistuba, I; Aguayo, F.; Cumsille, MA; Palma M.; Riquelme E.; Argandoña J.; Luengo, V; Akiba S.; Koriyama C.; Eizuru Y. Abstract JOURNAL OF MOLECULAR DIAGNOSTICS (2004)
Detection of oligoclonal immunoglobulins heavy chain gene rearrangement (IgH) by melting curve analysis in gastric lymphoid infiltrates. Corvalan, A; Retamales E.; Guzman, L; Torres J.; Riquelme E.; Palma M.; Backhouse, C. Abstract JOURNAL OF MOLECULAR DIAGNOSTICS (2004)


Early Diagnosis of Hepatocellular Carcinoma by MicroRNAs: Shining a Light from the Genome's "Dark Matter" Corvalán A.H. EditorialMaterial ISI SCOPUS Digestive Diseases and Sciences (2012)


Author Correction: The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish (Scientific Reports, (2019), 9, 1, (7131), 10.1038/s41598-019-43436-8) Stanic K.; Reig G.; Figueroa R.J.; Retamal P.A.; Wichmann I.A.; Opazo J.C.; Owen, G. I.; CorvalÃ¡n A.H.; Concha M.L.; Amigo J.D. Errata ISI SCOPUS SCIENTIFIC REPORTS (2020)


The upregulation of long-noncoding RNA, a novel opportunity to address the complexities of the pathogenesis of gastric cancer FONDECYT (1191928) Proyecto 2019-2020 Inv. Principal
SCREENING OF GASTRIC CANCER VIA BREATH VOLATILE ORGANIC COMPUNDS BY HYBRID SENSING APROACH H2020 - European Union (SEP-210510439) Proyecto 2018-2022 Coinvestigador(a)
EPIDEMIOLOGY AND RISK STRATIFICATION OF GASTRIC CANCER PRECURSOR LESIONS National Institute of Health, USA (6182-S20) Proyecto 2017-2018 Inv. Principal
ROLE OF MICRORNAS IN THE PATHOGENESIS OF GASTRIC CARCINOMA AND DEVELOPMENT OF NON-INVASIVE STRATEGIES FOR EARLY DETECTION FONDECYT (1151411) Proyecto 2015-2018 Inv. Principal
ADVANCED CENTER FOR CHRONIC DISEASES (ACCDiS) FONDAP (15130011) Proyecto 2013-2017 Inv. Principal
PLATAFORMA TRANSVERSAL DE PIROSECUENCIACIÓN PARA EL ESTUDIO DE ALTERACIONES EPIGENÉTICAS Y POLIMORFISMOS FONDEQUIP (EQM120205) Proyecto 2013-2015 Coinvestigador(a)
ROLE OF HPV-16 E6 AND E7 ONCOPROTEINS IN TOBACCO-SMOKE ASSOCIATED CARCINOGENESIS=> INTERACTION BETWEEN CIGARETTE SMOKE COMPONENTS (CSC) AND HPV16 E6/E7 ONCOPROTEINS IN ORAL AND BRONCHIAL EPITHELIAL CELLS AND CLINICAL SPECIMENS. FONDECYT (1120248) Proyecto 2012-2015 Coinvestigador(a)
ROLE OF REPRIMO, A P53-DEPENDENT G2 ARREST MEDIATOR CANDIDATE, IN THE PATHOGENESIS OF HUMAN GASTRIC CARCINOMA FONDECYT (1111014) Proyecto 2011-2014 Inv. Principal
TEST DE TAMIZAJE PARA LA DETECCIÓN PRECOZ DE CÁNCER GÁSTRICO FONDEF (D09I1137) Proyecto 2011-2013 Director(a)
EPIGENETIC BASES OF GASTRIC CARCINOMA PATHOGENESIS AND STRATEGIES FOR EARLY DETECTION FONDECYT (1080563) Proyecto 2008-2010 Inv. Principal
EPIGENETIC STATUS OF TUMOR SUPRESSOR GENES OF NON SMALL CELL LUNG CANCER (NSCLC) AND CORRELATION WITH MICRORNAS PCI (066-2008) Proyecto 2008-2009 Inv. Principal
EVALUATION AND CONTROL OF NEGLECTED MUCOSA ENTERIC INFECTIONS IN CHILDHOOD (CONTENT) Union Europea (Unión Europea - 2006 - RUE29 - CONICYT #RUE29.) Proyecto 2006-2009 Coinvestigador(a)
EVOLUCIÓN DE LA INFECCIÓN GENITAL POR VIRUS PAPILLOMA HUMANO (VPH) EN UNA COHORTE DE MUJERES CHILENAS ESTUDIADAS EL AÑO 2000 FONDECYT (1060645) Proyecto 2006-2008 Coinvestigador(a)
MARCADORES DE DETECCIÓN PRECOZ DE CÁNCER GÁSTRICO FONIS (SA06I20019) Proyecto 2006-2007 Inv. Principal
PATRON DE METILACION DE GENES SUPRESORES DE TUMORES EN LA PATOGENESIS DEL CANCER GASTRICO DIFUSO FONDECYT (7050076) Proyecto 2005-2006 Inv. Responsable
BUSQUEDA DE GENES PARTICIPANTES EN LA GENESIS Y EL DESARROLLO DE CANCER DE MAMA HEREDITARIO. FONDECYT (1040779) Proyecto 2004-2008 Coinvestigador(a)
PATRON DE METILACIÓN DE GENES SUPRESORES DE TUMORES EN LA PATOGÉNESIS DEL CANCER GÁSTRICO DIFUSO FONDECYT (1030130) Proyecto 2003-2005 Inv. Principal


Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama Corvalán, Alejandro PuntoDeVista SCIELO REVISTA MEDICA DE CHILE (2007)


The Phylogeographic Diversity of EBV and Admixed Ancestry in the Americas-Another Model of Disrupted Human-Pathogen Co-Evolution Corvalan, AH; Ruedlinger, J; de Mayo, T; Polakovicova, I; Gonzalez-Hormazabal, P; Aguayo, F Review ISI SCOPUS CANCERS (2019)
Epigenetics in the pathogenesis and early detection of gastric cancer Corvalan, A Review ISI REVISTA MEDICA DE CHILE (2013)
Teneurin protein family: An emerging role in human tumorigenesis and drug resistance Ziegler, A; Corvalan, A; Roa, I; Branes J.A.; Wollscheid B. Review ISI SCOPUS Cancer Letters (2012)

115

ALEJANDRO CORVALAN

Principal Investigator

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Francisco Aguayo

Profesor Asociado

Programa de Virología, Instituto de Ciencias Biomédicas (ICBM)

Universidad de Chile

Santiago, Chile

fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

María Maturana

Bioquimico

Pontificia Universidad Católica de Chile

Santiago, Chile

Diego Carrillo

Profesor auxiliar

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

Rancés Blanco

Profesional Senior

Plataforma de Apoyo a la Investigación

Pontificia Universidad Católica de Chile

Santiago de Chile, Chile

Matías Muñoz

Research Assistant

Universidad Mayor de Chile

Santiago, Chile

Leda Guzman

Profesor Adjunto

Instituto de Química

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Ignacio Wichmann

Assitant Professor

Obstetrics

Pontificia Universidad Católica de Chile

Santiago, Chile

Tomas de Mayo

PROFESOR ASOCIADO

CIENCIAS

UNIVERSIDAD MAYOR

SANTIAGO, Chile

SOLEDAD BOLLO

PROFESOR TITULAR

QUIMICA FARMACOLÓGICA Y TOXICOLÓGICA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

jose valbuena

Associate Professor

Anatomic Pathology

PONTIFICIA UNIVERSIDAD CATOLICA. FACULTAD DE MEDICINA/ESCUELA DE MEDICINA/ DEPARTAMENTO DE ANATOMÍA PATOLÓGICA

santiago, Chile

ULISES URZUA

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

Hugo Verdejo

Profesor Asociado

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

Maria Solis

Profesor Asociado

Instituto de Ciencias de la Salud

Universidad de O´Higgins

Rancagua, Chile

María Marchant

Profesor Postdoctoral

Química

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

Teresa Tapia

Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Natalia Landeros

Investigadora

Facultad de Medicina

Universidad Católica del Maule

Talca, Chile

Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Yolanda Vargas

Profesor Asociado

Producción Vegetal

UNIVERSIDAD DE CONCEPCIÓN

Chillán, Chile

Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

Marcelo Garrido

Director

CENTRO DEL CÁNCER, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

Ignacio Retamal

Docente

Universidad de Los Andes

Santiago, Chile

Cynthia Villarroel

Bárbara Parra

Profesional de Laboratorio

BIOMEDICO Y NACIONAL DE REFERENCIA

INSTITUTO DE SALUD PUBLICA

Santiago, Chile

Wilda Olivares

Bioquímico-Asistente en investigación y Coordinadora de Proyectos de Investigación.

hematologia oncologia

Pontificia Universidad Católica de Chile

santiago, Chile

Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

Jaime Madariaga

ASSOCIATE PROFESSOR

MEDICAL SPECIALTIES

UNIVERSITY OF CONCEPCION

CONCEPCION, Chile

Kurt Buchegger

Investigador Postdoctoral

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

jaime villegas

Profesor Asistente

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Vinicius Ramos Henriques

Associate Professor

Advanced Center for Chronic Diseases - ACCDiS

Univesidad de Chile

Santiago, Chile

Erica Koch

Oncólogo Médico

Red de Salud UC Christus

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Jorge Cancino

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

Edison Salas

Director de laboratorio de nanotecnología

Aintech

Santiago, Chile

Cesar Sanchez

Profesor asistente

Hematologia-oncologia

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

santiago, Chile

Paulina Orellana

Coordinadora traslacional

Universidad de Chile

Santiago, Chile

Miguel Cordova

Estudiando de Doctorado

Departamento de Posgrado

Universidad de Chile

Santiago, Chile

Vanessa Van De Wyngard

Investigadora

Escuela de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Daniela Báez

Investigadora Asociada

Universidad de Talca

Talca, Chile

Maria Cordero

Profesora asistente

Departamento de Física

UNIVERSIDAD DE CHILE

Santiago, Chile

Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

Eyleen Araya

Academic

Chemical Sciences

Universidad Andres Bello

santiago, Chile

Simon Guerrero

Investigador

Instituto de Investigación Interdisciplinar en Ciencias Biomédicas SEK

Universidad SEK

Santiago, Chile

Francisco Acevedo

Medico Oncologo

Hemato Oncologia

Pontificia Universidad Católica de Chile

Santiago, Chile

FERNANDO CROVARI

Jefe Departamento

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo Guzmán

Pathologist

Hospital Regional Dr. Hernán Henríquez Araven

Temuco, Chile

FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Jenny Ruedlinger

INVESTIGADOR POSTDOCTORAL EN PROYECTO MAUCO

SALUD PÚBLICA

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

Paula Díaz

Coordinadora de Investigación y Postgrado

Facultad de Salud

Universidad Santo Tomás

Santiago, Chile

Aurora Molinari

Profesor Titular

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

VALPARAISO, Chile

Juan Opazo

Profesor Titular

Facultad de Medicina y Ciencia

Universidad San Sebastián

Valdivia, Chile

German Reig

Investigador Principal

Centro integrativo de Biología y Química Aplicada

Universidad Bernardo O'Higgins

Santiago, Chile

Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

María Tarnok

Profesor Agregado

Instituto de Química

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

KAREN DUBOIS

Postdoctoral fellow Fondef IDeA ID17I10064 IDI17

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Paola Viviani

Profesor Asistente, categoría Ordinaria

Salud Pública

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Victor Aliaga

Postdoctorante

Universidad de O'Higgins

Santiago, Chile

CLAUDIA BAMBS

PROFESORA ASOCIADA

SALUD PÚBLICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Constanza Camargo

Investigador

Division of Cancer Epidemiology and Genetics

National Cancer Institute, USA

Rockville, Estados Unidos

Natalia Hassan

Coordinadora

Universidad Tecnológica Metropolitana

Santiago, Chile

Laura Huidobro

Encargada Investigación

Ciencias Preclínicas

Universidad Católica del Maule

Talca, Chile

MARIA DURAN

Estudiante

Universidad Mcgill

Montreal, Canada

Pablo Letelier

Docente Planta Permanente (Instructor)

UNIVERSIDAD CATOLICA DE TEMUCO

temuco, Chile

Hery Urra

Staff scientist

INSTITUTO DE NEUROCIENCIA BIOMEDICA (BNI)

Santiago, Chile

Javier Morales

Profesor Asociado

Departamento de Ciencias y Tecnología Farmacéuticas

Universidad de Chile

Santiago, Chile

Jaime Lopez

Asistente de Investigación

Anatomía Patologica

Universidad de La Frontera

Temuco, Chile

SERGIO BAEZ

SUBDIRECTOR MEDICO

CIRUGIA

HOSPITAL DR. SOTERO DEL RIO

SANTIAGO, Chile

Ismael Riquelme

Académico - Investigador

Ciencias de la Salud

UNIVERSIDAD AUTÓNOMA DE CHILE

Temuco, Chile

MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Ximena Aguilera

Full Professor; Director Centro de Epidemiología y Políticas de Salud /Center of Epidemiology and Health Policy

Centro de Epidemiología y Políticas de Salud (CEPS)/ Center of Epidemiology and Health Policy/Centro de Epidemiología y Políticas de Salud (CEPS)

Universidad del Desarrollo

Santiago, Chile

paula margozzini

Associate Professor

Public Health

Pontificia Universidad Católica de Chile

Santiago, Chile

Gabriel Bastias

Profesor Asociado

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Enrique Castellón

Profesor Titular. Director

Oncología Básico-Clínica

UNIVERSIDAD DE CHILE

Santiago, Chile

Juan Araya

Pathologist

Anatomía Patológica

Hospital Dr. Hernan Henríquez Aravena

Temuco, Chile

Priscilla Brebi

Profesor Asociado

Departamento de Anatomía Patológica.

Universidad de La Frontera

Temuco, Chile

Carmen Ili

Academico Asociado

Scientific and technological Bioresource Nucleus (BIOREN)

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

Alejandro Maass

Main Researcher

Center for Mathematical Modeling

Universidad de Chile

Santiago, Chile

Carolina Alvarez

Profesor Asociado Planta Especial Docente

PONTIFICIA UNIVERSIDAD CATÓLICA CHILE

Santiago, Chile

Claudia Gonzalez

Associate Professor and Resarcher

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

Franz Villarroel

Jefe Laboratorio - PI

Departamento de Investigación del Cáncer

Fundación Arturo López Pérez

Santiago, Chile

Giuliano Bernal

Profesor Titular

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

Jonas Chnaiderman

Profesor Asociado

Instituto de Ciencias Biomédicas

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Claudia Foerster

Associate Professor

Institute of Agri-food, Animal and Environmental Sciences

Universidad de O'Higgins

San Fernando, Chile

Alejandro Corvalan

Assistant Professor

Industrial Engineering

Universidad de Chile

Santiago, Chile

Aldo Gaggero

Académico. Profesor Asociado.

Virología

ICBM. FACULTAD DE MEDICINA. UNIVERSIDAD DE CHILE.

Santiago, Chile

Alvaro Muñoz

Profesor Titular

Universidad San Sebastián

Santiago, Chile

María Rodríguez

Profesora Asociada

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Johanna Acevedo

Profesor asociado investigador

Instituto de Ciencias e Innovación en Medicina (ICIM)

Universidad del Desarrollo

Santiago, Chile

Pilar Cárdenas

Asistente de investigación Fisiología y Bioquímica renal

Instituto de Química

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

Denisse Bravo

Associate Professor

Pathology and Oral Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Luigi Devoto

PROFESOR TITULAR

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL,FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Waldo Acevedo

Profesor Asociado

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

Charlotte Hill

Postdoctoral Fellow

Pedriatrics

Boston Childrens Hospital, Harvard Medical School

Boston, Estados Unidos

ALEJANDRO HERNAN CORVALAN RODRIGUEZ

Líneas de Investigación

Educación

Medical Doctor, EDUCATIONAL COMMISION FOR FOREIGN MEDICAL GRADUATES. Estados Unidos, 1989

Medical Doctor, UNIVERSIDAD DE CHILE. Chile, 1985

Cell Biology, UNIVERSIDAD DE CHILE. Chile, 2006

Experiencia Académica

Full Professor Full Time

Assistant Professor Full Time

Experiencia Profesional

Director Molecular Biology Laboratory Part Time

CSO Part Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

AVONNI en Salud

Premio Academia Medicina

Oncologo del Año

Article (104)

Abstract (12)

EditorialMaterial (1)

Errata (1)

Proyecto (17)

The upregulation of long-noncoding RNA, a novel opportunity to address the complexities of the pathogenesis of gastric cancer

SCREENING OF GASTRIC CANCER VIA BREATH VOLATILE ORGANIC COMPUNDS BY HYBRID SENSING APROACH

EPIDEMIOLOGY AND RISK STRATIFICATION OF GASTRIC CANCER PRECURSOR LESIONS

ROLE OF MICRORNAS IN THE PATHOGENESIS OF GASTRIC CARCINOMA AND DEVELOPMENT OF NON-INVASIVE STRATEGIES FOR EARLY DETECTION

ADVANCED CENTER FOR CHRONIC DISEASES (ACCDiS)

PLATAFORMA TRANSVERSAL DE PIROSECUENCIACIÓN PARA EL ESTUDIO DE ALTERACIONES EPIGENÉTICAS Y POLIMORFISMOS

ROLE OF HPV-16 E6 AND E7 ONCOPROTEINS IN TOBACCO-SMOKE ASSOCIATED CARCINOGENESIS=> INTERACTION BETWEEN CIGARETTE SMOKE COMPONENTS (CSC) AND HPV16 E6/E7 ONCOPROTEINS IN ORAL AND BRONCHIAL EPITHELIAL CELLS AND CLINICAL SPECIMENS.

ROLE OF REPRIMO, A P53-DEPENDENT G2 ARREST MEDIATOR CANDIDATE, IN THE PATHOGENESIS OF HUMAN GASTRIC CARCINOMA

TEST DE TAMIZAJE PARA LA DETECCIÓN PRECOZ DE CÁNCER GÁSTRICO