Man

Mariana Cifuentes Koster

Professor

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


OBESIDAD; ENFERMEDADES CRONICAS DE ORIGEN NUTRICIONAL; Receptor sensor de calcio en el tejido adiposo; Obesidad e inflamacion; Fisiologi­a tejido adiposo, cell signaling

Educación

  •  Chemist Pharmacist, UNIVERSIDAD DE CHILE. Chile, 1997
  •  Nutritional Sciences, RUTGERS UNIVERSITY. Estados Unidos, 2002

Experiencia Académica

  •   Instructor Full Time

    UNIVERSIDAD DE CHILE

    Instituto de Nutrición y Tecnologia de los Alimentos

    Santiago, Chile

    Enero 2003 - Enero 2005

  •   Asistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Instituto de Nutrición y Tecnologia de los Alimentos

    Santiago, Chile

    Enero 2005 - Enero 2011

  •   Associate Professor Full Time

    UNIVERSIDAD DE CHILE

    Instituto de Nutrición y Tecnologia de los Alimentos

    Santiago, Chile

    Enero 2011 - Enero 2017

  •   Professor Full Time

    UNIVERSIDAD DE CHILE

    Instituto de Nutrición y Tecnología de los Alimentos

    Santiago, Chile

    Enero 2017 - A la fecha

Formación de Capital Humano


Ph.D. and M.Sc POST-GRADUATE STUDENTS

Post-doctoral fellows
Roberto Bravo-Sagua (2018)

Ph.D. THESIS STUDENTS
1) Pia Villarroel (2016)
2) Amanda D'Espessailles (2018)
3) Pamela Mattar (co-tutored, 2018)
4) Lautaro Briones (Co-tutored, in progress)

M.Sc. THESIS STUDENTS
1) Ximena Díaz (co-tutored, Jun 2009)
2) Pamela Mattar (Jan 2011)
3) Pía Segovia (Aug 2011)
4) Andrea Arreguin (Jul 2012)
5) Elisa Villalobos (Dec 2012)
6) Gladys Rocha (Sep 2014)
7) Maria de los Angeles Spencer (2017)
8) Yuly Andrea Mora (2017)
9) Sofía Sanhueza (co-tutored, 2019)
10) Natalia Santillana (In progress)
11) Karin Herrera (co-tutored, in progress)
12) Gabriela Yuri (co-tutored, in progress)
13) Elizabeth Trejo (co-tutored, in progress)

POST-GRADUATE LECTURE COURSES
Creator or co-creator of 2 post-graduate courses of the University of Chile:
Improving Skills in Nutrition Research I and II (Creator & lecturer)
Investigation Workshop: the Thesis Challenge (Co-Creatorr & lecturer).
Lecturer in 3 other post-graduate courses per year.

UNDERGRADUATE STUDENT TRAINING IN THE LAB
Tutoring of international undergraduate students from Michigan University (MHIRT program, 3-month program in)


Difusión y Transferencia


DISSEMINATION ARTICLES

04/2018 Artículo Nutrición y Vida "La obesidad es más que un tema estético: derribando mitos sobre la grasa" http://nutricionyvida.cl/la-obesidad-es-mas-que-un-tema-estetico-derribando-mitos-sobre-la-grasa/
11/2018 Artículo Nutrición y Vida “Científicos y sociedad: Aprendiendo a entendernos en tiempos de la postverdad” http://nutricionyvida.cl/cientificos-y-sociedad-aprendiendo-a-entendernos-en-tiempos-de-la-postverdad/?fbclid=IwAR2LdAE2LXPr6eT4JoMFa2oW-TtAPOm7lxZ7bQyhL0nXQLNAMiOSo-Jr5FA
11/2012 Update article for the Health Ministry (MINSAL): Cifuentes M. Calcio y salud ósea: un alto riesgo de deficiencia (Calcium and bone health: a high risk of deficiency). In: Informe Final "Estudio para Revisión y Actualización de las Guías Alimentarias para la Población Chilena". Santiago: MINSAL; 2012. p 92-96.
07/2012 Article “Instituto de Nutrición y Tecnología de los Alimentos (INTA)- Mariana Cifuentes: Receptor Sensor de Calcio en el Tejido Adiposo Humano” (Institute of Nutrition and Food Technology- M. Cifuentes: Calcium sensing receptor in human adipose tissue) for Universidad de Chile's 2010-2011 Annual Report.
08/2011 Article “Fisiología y Metabolismo del de Calcio y Fósforo” (Physiology and metabolism of calcium and phosphorus). Indualimentos Magazine, August 2011, pp. 48-50.Artículo
03/2006 Dissemination Article for Soprole, Q&A format on calcium nutrition for general public.
05/2005 Article “Efectos del Calcio en la Regulación del Peso Corporal” (calcium effects on body weight regulation) for Nestlé's Chilean webpage..

INTERVIEWS

01/2015 Interview, Nutrición y Vida Magazine, Nº13 Jan-Mar 2015 “La libertad y el desafío de ir un paso adelante” (Freedom and the challenge of going one step ahead).
02/2015 Interview, El Mercurio “Jóvenes investigadores develan las dificultades de hacer ciencia en Chile” (Young investigators reveal the difficulties of the scientific work in Chile). published on Feb 9, 2015 sección Vida-Ciencia-Tecnología (Life-Science-techcnology section).
11/2014 Guest at the radio show “La justa medida”, radio Cooperativa, Nov 2014. Tema de la entrevista: “La importancia del estudio de la grasa en la obesidad” (the relevance of fat studies in obesity).
09/2003 Interview “Dietas rápidas y de moda: Una atracción fatal” (quick and popular diets: a fatal attraction" for Revista Mujer, La Tercera, Sept 28th 2003 edition.
01/2003 Interview “Dieta rica en lácteos reduciría grasa corporal: últimas investigaciones en Estados Unidos y Europa sorprenden a expertos” (Dairy-rich diets may reduce body fat, latest research in USA and Europe surprise the experts) Nutrition XXI MagazineJan/Feb Edition 2003 (Nº9).

Talks and Conferences

10/2018 Expositora (Charla y mesa redonda) Programa Explora, Facultad de Medicina UChile. “Obesidad: Verdades y Mitos” Centro de Estudios en Ejercicio, Metabolismo y Cáncer - CEMC. Universidad de Chile - Semana Nacional de la Ciencia y la Tecnología-Explora 2018
10/ 2018 Charla UDD Facultad de Medicina Clínica Alemana - Universidad del Desarrollo
ACTUALIZACIONES EN MEDICINA INTERNA “FISIOPATOLOGÍA DEL SÍNDROME METABÓLICO: ROL DEL TEJIDO ADIPOSO ECTÓPICO”
09/2018 NEW BASIC AND CLINICAL INSIGHTS INTO OBESITY SYMPOSIUM: Talk: “Adipose tissue Dysfunction and Metabolically Healthy vs Unhealthy Obesity: a role for the Calcium Sensing Receptor”
08/2018 XXIII Reunión anual Sociedad Chilena de Ciencias Fisiológicas Participation in Symposium "Beyond energy depot in adipose tissue" with the talk "Adipose tissue Dysfunction and Metabolically Healthy vs Unhealthy Obesity: a role for the Calcium Sensing Receptor”
08/2017 Sociedad Chilena de Nutrición (SOCHINUT), XXI Jornadas de Nutrición. Simposio : “Obesidad y nutrición balanceada” Talk: "Obesidad: Perspectiva desde el tejido adiposo"
11/2016 Talk at the Advanced Center for Chronic Diseases- ACCDiS Seminar Series "Disfunción del Tejido Adiposo: Obesidad Metabólicamente “Sana” vs. “Enferma” y Papel del Receptor Sensor de Calcio". (Adipose tissue dysfunction: metabolically healthy and unhealthy obesity and the role of the calcium sensing receptor)
10/2016 Universidad de Chile, INTA Seminar Series “Disfunción del tejido adiposo en obesidad: papel del receptor sensor de calcio” (Adipose tissue dysfunction in obesity: role of the calcium sensing receptor)
08/2016 Talk at the Biological Sciences Department, Catholic University Physiology Seminar series “Disfunción del tejido adiposo en obesidad: papel del receptor sensor de calcio” (Adipose tissue dysfunction in obesity: role of the calcium sensing receptor)
10/2015 Talks: “Adipose Tissue and Obesity” y “Calcium Sensing Receptor and Adipose Tissue Dysfunction in Obesity” International Theoretical & Practical Course “Metabolic Signaling and Chronic Disease” Advanced center for chronic diseases (ACCDiS) Santiago, Chile Oct 5-9, 2015
11/2013 Talk: “Receptor Sensor Calcio y Disfunción del tejido adiposo” (Calcium sensing receptor and adipose tissue dysfunction). Symposium at the XXX Joint Meeting of the Chilean Nephrology and Hypertension Societies; Nov 14, 2013 Chillán, Chile
11/2013 Universidad de Chile, INTA Seminar Series “Receptor Sensor de Calcio y Disfunción del Tejido Adiposo”(Calcium sensing receptor and adipose tissue dysfunction)
08/2013 Talk: “Remodelamiento del tejido adiposo durante el ciclo vital” (Adipose tissue remodeling in the life cycle), for the “Fisiología del tejido adiposo” (adipose tissue physiology) Symposium; at the course “Tejido adiposo como órgano endocrino: Desde las ciencias fundamentales a la clínica” (Adipose tissue as an endocrine organ: from basic sciences to clinical studies), Sociedad Chilena de Endocrinología y Diabetes August 23, 2013, Santiago, Chile
05/2013 Talk: “Grasa Visceral versus Grasa Subcutánea” (Visceral vs subcutaneous fat) VII Chilean Meeting of Clinical Nutrition and Metabolism; May 31, 2013 Viña del Mar, Chile
10/2012 Talk: “Receptor Sensor de Calcio y Disfunción del Tejido Adiposo” (Calcium sensing receptor and adipose tissue dysfunction) Nutrition Dept, Pontificia Universidad Católica.
08/2012 Talk: “Receptor Sensor de Calcio y Disfunción del Tejido Adiposo” (Calcium sensing receptor and adipose tissue dysfunction) Centro médico Obesidad group.
04/2011 Universidad de Chile, INTA Seminar Series “Receptor Sensor de Calcio y Disfunción del Tejido Adiposo”(Calcium sensing receptor and adipose tissue dysfunction)
11/2010 Conference “Metabolismo y adipocitos” (metabolism and adipocytes) at the XVII Jornadas, Chilean Nutrition Society, Santiago, Nov 24, 2010.
10/2009 Universidad de Chile, INTA Seminar Series “Receptor Sensor de Calcio en el Adipocito Humano” (Calcium sensing receptor in the human adipocyte)
10/2009 Fall 2009 Nutrition Seminar Series “Calcium Sensing Receptor in the Human Adipocyte” Boston University, Massachussets, USA
10/2009 Rutgers University Nutritional Sciences Department Seminar Series “Calcium Sensing Receptor in the Human Adipocyte” Rutgers University, New Jersey, USA.
10/2009 Graduate program workshop “Challenges in Research” Rutgers University, New Jersey , USA.


Premios y Distinciones

  •   Henri Nestlé Award to Scientific Research

    NESTLE CHILE S.A.

    Chile, 2009

    First place prize for the paper entitled "Antilipolytic effect of calcium-sensing receptor in human adipocytes” (Mol Cell Biochem. 2008; 319(1-2):17-21)

  •   Obesity Society Basic Science Section 2015 Poster Competition

    Obesity Society

    Estados Unidos, 2015

    FIrst prize for the poster “Calcium sensing receptor stimulation in adipose and hepatic cells: possible implications in the metabolic consequences associated with obesity” presented at The Obesity Society's Annual meeting at ObesityWeek, Los Angeles, CA, USA.

  •   University Research Prize

    Banco Santander- El Mercurio

    Chile, 2014

    Prize to University Research on obesity and its impact on Chilean health, basic science category.

  •   Best work presented at the XXVII chilean internal medicine meeting

    Chilean Internal Medicine Society

    Chile, 2005

    FIrst prize to the work presented "Determinant role of small adipocytes on lipolysis and lipogenesis in obese and non-obese adults”

  •   “Predoctoral recognition award”.

    Association for Women in Science Educational Foundation (AWIS)

    Estados Unidos, 2001

    Predoctoral recognition award for the doctoral Thesis project “Hormonal regulation of calcium metabolism: the influence of body weight”.


Tipos de Producción
 

Article (32)

Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes
Calcium-sensing receptor activates the NLRP3 inflammasome in LS14 preadipocytes mediated by ERK1/2 signaling
Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase of ER stress
Calcium Sensing Receptor as a Novel Mediator of Adipose Tissue Dysfunction: Mechanisms and Potential Clinical Implications
Calcium sensing receptor effects in adipocytes and liver cells: Implications for an adipose-hepatic crosstalk
Regulation of cardiomyocyte autophagy by calcium
Obesity is associated with acute inflammation in a sample of adolescents
Preadipocyte proliferation is elevated by calcium sensing receptor activation
Calcium, obesity and the role of the calcium sensing receptor.
Identification of novel 11 beta-HSD1 inhibitors by combined ligand- and structure-based virtual screening
Obesity is associated with acute inflammation in a sample of adolescents.
Adipogenic effect of calcium sensing receptor activation
Antilipolytic effect of calcimimetics depends on the allelic variant of calcium-sensing receptor gene polymorphism rs1042636 (Arg990Gly)
Calcium sensing receptor activation elevates proinflammatory factor expression in human adipose cells and adipose tissue
Energy Restriction Is Associated with Lower Bone Mineral Density of the Tibia and Femur in Lean but Not Obese Female Rats
The anti-adipogenic effect of angiotensin II on human preadipose cells involves ERK 1,2 activation and PPARG phosphorylation
The anti-adipogenic effect of angiotensin II on human preadipose cells involves ERK1,2 activation and PPARG phosphorylation
Antilipolytic effect of calcium-sensing receptor in human adipocytes
Differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes
Effects of replacing the habitual consumption of sugar-sweetened beverages with milk in Chilean children
Larger anti-adipogenic effect of angiotensin II on omental preadipose cells of obese humans
Calcium-sensing receptor expression in human adipocytes
Overweight Postmenopausal Women Lose Bone With Moderate Weight Reduction and 1 g/day Calcium Intake
Estrogen prevents the reduction in fractional calcium absorption due to energy restriction in mature rats
Intestinal FABP2 A54T polymorphism: Association with insulin resistance and obesity in women
Bone turnover and body weight relationships differ in normal-weight compared with heavier postmenopausal women
Osteopontin Facilitates Bone Resorption, Decreasing Bone Mineral Crystallinity and Content During Calcium Deficiency
Precise and accurate determination of calcium isotope ratios in urine using HR-ICP-SFMS
Energy restriction reduces fractional calcium absorption in mature obese and lean rats
Energy restriction reduces bone density and biomechanical properties in aged female rats
. Identification of novel 11β-HSD1 inhibitors by combined ligand- and structure-based virtual screening

Grant (14)

Soft drinks, milk and obesity in Chilean children

Generic (5)

Obesity-associated proinflammatory cytokines increase calcium sensing receptor (CaSR) protein expression in primary human adipocytes and ls14 human adipose cell line
Antilipolytic effect of calcium sensing receptor activation in human adipocytes
Impact of milk consumption on BMI and height in children
Association of serum TNFa and its soluble receptors STNFR1 and STNFR2 with obesity and insulin resistance
Estrogen prevents the reduction in fractional calcium absorption due to energy restriction in mature rats.

Book Section (3)

Calcium in Obesity and Related Diseases: The Calcium-Sensing Receptor as a Novel Mediator
Adipose Tissue and Desmoplastic Response in Breast Cancer
Drug-Nutrient Interactions that Impact on Mineral Status

Review (2)

ER-to-mitochondria miscommunication and metabolic diseases
Calcium, obesity, and the role of the calcium-sensing receptor

Book Whole (1)

Body weight/composition and weight change: Effects on bone health

Abstract (1)

Calcium sensing receptor and obesity: Influence on adipose tissue dysfunction

Nil Class (0)

58
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

9
Cecilia Albala

Director, full professor

INTA/U CHILE

Santiago, Chile

6
Marcela Reyes

Profesor Asistente

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE LOS ALIMENTOS (INTA)

Santiago, Chile

4
Pia Villarroel

Docente investigador

UNIVERSIDAD MAYOR

Santiago, Chile

3
Lydia Lera

Profesor Asociado

INTA University of Chile

Santiago de Chile, Chile

3
Roberto Bravo

Investigador Postdoctoral

Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile

Santiago, Chile

3
Nicolas Tobar

Assistan Professor

Celullar Biology Laboratory

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS, INTA-UCHILE

Santiago, Chile

2
Maria Acuña

Academico Investigador

Salud

Universidad Bernardo O´Higgins

Santiago, Chile

2
Jorge Martinez

Profesor Titular

Laboratorio de Biología Celular

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE ALIMENTOS (INTA), UNIVERSIDAD DE CHILE

Santiago, Chile

2
Rodrigo Troncoso

Assistant professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Sandra Solari

Profesor Asociado

Departamento Laboratorios Clinicos - Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Marco Arrese

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Jose Santos

Full Professor

Department of Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Cristian Carvajal

Assistant Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

1
Eugenia Morselli

Profesor Asistente de Planta Ordinaria

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

1
Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Gareth Owen

Profesor Titular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile