Man

Francisco Javier Nualart Santander

Full Professor and Scientific Director

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Líneas de Investigación


Neurobiology, Cancer, Stem Cells, Death Cell, Vitamin C, Glucose and Vitamin C Transporters, aging, Choroid Plexus Cells Biology

Educación

  •  Biologist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1986
  •  Sciences with Histology mention, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1989
  •  Cell and Molecular Biology, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1995

Experiencia Académica

  •   Instructor Full Time

    UNIVERSIDAD AUSTRAL DE CHILE

    Medicine

    Valdivia, Chile

    Enero 1989 - Enero 1990

  •   Assistant Professor Part Time

    UNIVERSIDAD DE LA FRONTERA

    Medicine

    Temuco, Chile

    Enero 1993 - Enero 1995

  •   Associate Professor and Chairman Full Time

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    Chile

    Enero 1995 - Enero 2003

  •   Full Professor and Scientific Director Full Time

    UNIVERSIDAD DE CONCEPCION

    Biological Sciences

    Concepción, Chile

    Enero 2004 - A la fecha

  •   Post-Doc Full Time

    MEMORIAL SLOAN-KETTERING CANCER CENTER

    Estados Unidos

    Enero 1997 - Enero 1998

Experiencia Profesional

  •   Director Full Time

    Departament of Cell Biology

    Chile

    Enero 2004 - Enero 2014

  •   Scientific Director Part Time

    Center for Advanced Microscopy CMA BIO BIO

    Chile

    Enero 2010 - A la fecha

  •   Director Full Time

    Department of Histology and Embriology

    Chile

    Enero 2002 - Enero 2003

  •   Referee member Part Time

    Study Section III (Neurosciences, Molecular Biology and Pharmacology), FONDECYT, Chile

    Chile

    Enero 2006 - Enero 2008

  •   Referee member Part Time

    Fondequip evaluation Committee

    Chile

    Enero 2011 - Enero 2015

  •   Regional Director Part Time

    Chilean Society of Neuroscience

    Chile

    Enero 2008 - Enero 2009

  •   Member of the Young Latinamerica Scholars Committee Part Time

    American Society for Neurochemistry, USA

    Estados Unidos

    Enero 2009 - A la fecha

  •   Council Member, ISN-CC committee Part Time

    International Society of Neurochemistry

    Chile

    Enero 2009 - A la fecha

  •   Member of the post-graduate technical committee Part Time

    University of Concepcion

    Chile

    Enero 2010 - Enero 2013

  •   Member of the Academic Council, Faculty of Biological Sciences Part Time

    University of Concepcion

    Chile

    Enero 2001 - Enero 2014

  •   Member of the Study Section (Biological Sciences and Medicine) Part Time

    Accreditation National Committee, CNA, Chile

    Chile

    Enero 2008 - A la fecha

  •   Member of the Study Section (Biological Sciences and Medicine) Part Time

    Accreditation National Committee, CNA

    Chile

    Enero 2008 - A la fecha

  •   Representative of the Faculty of Biological Sciences in the Scientific-Technical Committee of Biomedicine Program Part Time

    University of Concepcion

    Chile

    Enero 2009 - Enero 2010

  •   President of Science Committee Part Time

    Acredita CI

    Chile

    Enero 2014 - A la fecha

  •   Evaluator Part Time

    National Research Agency, Francia,

    Francia

    Enero 2015 - Enero 2015

  •   Member Sectorial Council of the Faculty of Health Sciences Part Time

    San Sebastian University

    Concepción, Chile

    Enero 2012 - A la fecha

  •   Evaluator PhD Scholarships abroad, Scholarships Chile Part Time

    CONICYT

    Chile

    Enero 2012 - A la fecha

  •   Evaluator Post-Doctorate Scholarships abroad, Scholarships Chile Part Time

    CONICYT

    Chile

    Enero 2012 - A la fecha

  •   Evaluator Magister Scholarships, Physiology and Biochemistry committee. Part Time

    CONICYT

    Chile

    Enero 2012 - A la fecha

  •   Evaluator Magister Scholarships, Cell and Molecular Biology Committee Part Time

    CONICYT

    Chile

    Enero 2012 - A la fecha

  •   Evaluator Projects CONICYT-PCI-ECOS Part Time

    CONICYT

    Chile

    Enero 2014 - A la fecha

Formación de Capital Humano


Formation of Human Capital

Undergraduate

1. Alejandro Godoy."Characterization of glucose transporters in cancer". Medical Technologist Undergraduate, Frontera University. 1995. Tutor

2. Claudio Aguayo."Characterization of glucose transporters in human brain". Medical Technologist Undergraduate, Frontera University. 1995. Tutor

3. Carolina Balmaceda. "Immunolocalization and molecular characterization of the glucose transporter GLUT 1 in cartilaginous fish Scyliorhinus canicula and Schroedericthys chilensis and bony fish Oncorhynchus mykiss brains." Biologist Thesis. Concepción University. 2001. Tutor

4. Sofía Barberis."Hexose transporters expression in human prostate cancer". Biochemistry Undergraduate Thesis. Concepción University. 2000. Co-Tutor

5. Mónica Carrasco."GLUT1 localization and expression analysis in normal and neoplastic ependymal glia". Biochemistry Undergraduate Thesis. Concepción University. 2001. Tutor

6. Maite Castro. "Characterization of the transport of vitamin C in cells of the central nervous system". Biochemistry undergraduate Thesis. Concepción University. 2000. Tutor

7. Carola Millán."OSC-spondin: Analysis of expression in the subcommissural organ and partial sequencing of its mRNA in the rat OSC". Biochemistry Undergraduate Thesis. Austral University of Chile. 2002. Co-tutor. Co-Tutor

8. Claudio Morales. "Hexose transporters analysis in human malignant melanoma". Biochemistry Undergraduate Thesis. Concepción University. 2002. Tutor

9. Viviana Ulloa."Characterization of the transport of vitamin C in human tumor cells of the choroid plexus". Pharmacist Undergraduate Thesis. Concepción University. 2003. Co-Tutor

10. Patricia Pastor."Postnatal neurogenic niche differentiation, localization of the precursor cells (stem cells) in mouse and human." Biochemistry Undergraduate Thesis. Concepción University. 2003. Tutor

11. Carmen Silva. "Cellular markers in radial glia differentiation". Biochemistry Undergraduate Thesis. Concepción University. 2004. Tutor

12. Christian Cortés Campos. "MCT1 and MCT2 expression and localization in glial cells of the hypothalamus." Biochemistry Undergraduate Thesis. Concepción University. 2005. Co-Tutor

13. Marcela Low M."SVCT1 and SVCT2 polarization in kidney cells." Biochemistry Undergraduate Thesis. Concepción University. 2004. Tutor

14. Katterine Salazar."SVCT2 distribution in neurons and glial cells ". Biochemistry Undergraduate Thesis. Concepción University. 2003. Tutor

15. Pedro Cisternas F. "Study of Vitamin C recycling between astrocytes and neurons". Biochemistry Undergraduate Thesis. Concepción University. 2006. Co-Tutor

16. Karina Oyarce. “Vitamin C and neuronal differentiation”. Bioingeniering undergraduate Thesis. Concepción University. 2009 - 2010. Tutor
17. Nery Jara. “Neurogenesis and brain tumors”. Biochemistry Undergraduate Thesis. Concepción University. 2009 - 2010. Tutor

18. Gustavo Cerda. "Lentiviral vectors for SVCT2 overexpression". Bioingeniering Undergraduate Thesis. Concepción University. 2013. Co-Tutor

19. Luciano Ferrada. "Vitamin recycling between astrocytes and neurons and death induction". Bioingeniering Undergraduate Thesis. Concepción University. 2013. Tutor

20. Francisca Espinoza. "Effect of retinoic acid and ascorbic acid on the SVCT2 expression in neural stem cells". Biochemistry Undergraduate Thesis. Concepción University. 2015. Tutor

21. Victor Baeza. "Characterization of IIIG9 expression in ependymal cells". Biochemistry Undergraduate Thesis. Concepción University. (2015). Co-Tutor

22. María José Oviedo. "Analysis of the expression, localization and interaction of the isoforms of the protein phosphatase 1 (PPP1) and the ciliary protein IIIG9 in ependymal cells". Biochemistry Undergraduate Thesis. Concepción University. 2017. Co-Tutor

23. Rocío Magdalena Parra. "Effect of dehydroascorbic acid on neuronal metabolism". Biochemistry Undergraduate Thesis. Concepción University. (2019). Tutor

24. Cristian Sanzana. "Vitamin C transporters recycling in aging". Bioingeniering Undergraduate Thesis. Concepción University. (2019 in progress). Tutor

25. Ninoska Troncoso. "Bystander effect and ferroptosis induction". Bioingeniering Undergraduate Thesis. Concepción University. (2019 in progress). Tutor

Post-graduate

Master

1. Alejandro Godoy. "Expression and function of glucose transporters in cancer, with special emphasis on breast cancer cells". Master Thesis, Concepción University. Tutor. 2000.

2. Federico Rodríguez. "Vitamin C uptake in human glioma cells: Application of a model of resistance to cytostatic therapies". Master Thesis, Concepción University. Tutor. 2000.

3. Roberto Elizondo. Differential characterization of the ability to release lactate by cortical and hypothalamic glial cells. Master Thesis, Concepción University. Co-Tutor. 2010.

4. Paula Llanos. Inhibition of GLUT2 in hypothalamic tanycytes and its effect on food intake in vivo. Master Thesis, Concepción University. Co-Tutor. 2013.

PhD Thesis

1. María García. "Study of the expression and function of hexose transporters and vitamin C in normal and tumor ependymal cells". PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2001. Tutor.

2. Maite Castro. "Effect of vitamin C on glucose uptake and accumulation in neurons of the cerebral cortex". PhD Thesis. Cellular and Molecular Biology Program. Austral University of Chile. 2005. Tutors, Dr. Francisco Nualart, Dra. Ilona Concha.

3. Allisson Astuya. "Uptake and intracellular action of vitamin C in developing neurons and human neuroblastoma cell lines". PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2006. Tutor.

4. Tamara Castro. "Dynamic and polarized expression of Vitamin C transporters in kidney epithelial cells". PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2007. Tutor.

5. Carola Millán."Localization, regulation and inhibition of glucokinase in the hypothalamic glia and its regulation in eating behavior". PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2008. Tutor.

6. Carolina Balmaceda. "Cellular and molecular bases for explaining the phylogenetically model of glia-neuron metabolic coupling". PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2009. Tutor.

7. Viviana Ulloa."Looking for the molecular and functional bases to explain the entry of vitamin C into the brain through the choroid plexus." PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2009. Tutor.

8. Carmen Silva A."Effect of vitamin C and and factors released from the meninges into the in vitro differentiation of radial glia."PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2009. Tutor.

9. Katterine Salazar. “Vitamin C effect in neuronal differentiation, an in vitro approach”. PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2010. Tutor.

10. Patricia Pastor. “Neurogenic niche and SVCT2 expression”. PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2010. Tutor.

11. Christian Cortés. “MCTs participation in the glucose sensing mechanism based in the metabolic coupling glia-neuron”. PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2011. Co-Tutors, M.A. García, F. Nualart.

12. Fernando Martínez. “Glucose sensing mechanism in hypothalamic glial cells”. PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2012. Co-Tutors, MA. García, F. Nualart.

13. Marcela Low. “SVCT2 expression and vitamin C function in neuromuscular differentiation”. PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2010. Co-Tutors, JP Henríquez, F. Nualart.

14. Zahady Velásquez. “Localization and function of Fructose-1,6-bifosfatase rat brain”. PhD Thesis. Cellular and Molecular Biology Program. Austral University. 2011. Co-Tutors, JC Slebe, F. Nualart.

15. Pedro Cisternas. “Vitamin C recycling and glutamate effect in astrocytes”. PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2012. Tutor.

16. Andrea García. “Oxidized vitamin C affects NFkB activation in neurons”. PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2012. Tutor.

17. Daniel Sandoval. “Subcellular localization and SVCT2 functional activity in skeletal muscle cells”. PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2012. Co-Tutors, J.P. Henríquez, F. Nualart.

18. Karina Oyarce. “Effect of vitamin C in neuronal differentiation”. PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2015. Tutor.

19. Nery Jara. “Neurogenesis and their effect on tumor growth”. PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2016. Tutor.

20. Francisca Espinoza. "Effect of vitamin C recycling in the neurites formation". PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. (In progress). Tutor.

21. Eder Ramírez. "Functional role of vitamin C in glioblastoma progression". PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. (In progress). Tutor.

22. Natalia Saldivia. "Effect of vitamin C on the postnatal radial glia of normal brains and slc23a2 +/-. PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2017 (In progress). Tutor.

23. Víctor Baeza. "Study of the expression and function of IIIG9 in the differentiation and polarization of normal and tumor ependymal cells". PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2017 (In progress). Co-Tutor.

24. Luciano Ferrada. "Necroptosis in neuronal cells under oxidative stress". PhD Thesis. Cellular and Molecular Biology Program. Concepcion University. 2018. Tutor.

Post Docs

Dr. Viviana Ulloa, Supported by Innova Bio Bio Grant.
Dr. Katterine Salazar, Supported by DIUC Grant.
Dr. Katherin Forman, Supported by Fondecyt Grant.
Dr. Romina Bertinat, Supported by Fondecyt Grant.
Dr. Carolina Balmaceda. Assistant Professor UDD.
Dr. Fernando Martínez. Supported by Innova Bio Bio Grant.


Difusión y Transferencia


- CMA Brochure. January 2012, CMA Bío-Bío produces a brochure with information about the center.
- Biomedical Science. San Sebastian University invites the CMA to publish about the Center in its scientific journal. This magazine is distributed from Arica to Puerto Montt.
- Biological Sciences newsletter "In Touch". Volume 12 (1) July 2012.
Center for Advanced Microscopy Bio-Bio: a pole of services with application
technological, scientific and industrial of the highest level in the country.
- Chilean Society of Biochemistry and Molecular Biology. Web page
http://www.microscopy.info advertises the CMA as a microscope facility in Chile.
- Aquaculture "Technical Magazine Different Version, The magazine is distributed in 4000 copies to all Chilean Salmon farms, Crops Centers, Hatcheries, Process plants.
I D i Magazine University of Concepción. May 3, 2013 Inauguration of the CMA
Bio-Bio.
- In 2012, it participated in 3 radio programs of the University to discuss aspects related to Research, Post-Graduate Training and Research Projects and Microscopy.
- Talk "Confocal Laser Microscopy". Collegiate Institute of Humanities, 3rd and 4th media. Advanced Microscopy Center, University of Concepción. August 12, 2014.
- Science Day October 4, 2014. Advanced Microscopy Center. CMA BIO BIO. The Center was kept open for external visitors to the University.
- Different Version Magazine. Advanced Microscopy Center. Application in Salmon and Aquaculture. Number 20, 2014.
- Revista I D i UDEC, December 2013. Woman with first transplant of differentiated stem cells, tells her new life.
- Talk "Confocal Laser Microscopy". Collegiate Institute of Humanities, 3rd and 4th media. Advanced Microscopy Center, University of Concepción. August 12, 2014.
- University Radio radio program, information is prepared for 2015.
- Website Fac. Biological Sciences, UDEC, Center for Advanced Microscopy Biobío, a center of excellence in the service of research. Tuesday, July 7, 2015. http://csbiolmas.blogspot.com/2015/07/centro-de-microscopia-avanzada-biobio.html.
- El Mercurio journal. Special editions. "Postgraduate Supplement in the South". Leaders in Confocal Microscopy. Sunday, July 12, 2015.
- EL MERCURIO. Special editions "Postgraduate Supplement in the South". CMA BIO BIO. Referent in light microscopy technologies. Sunday, July 12, 2015.
- UDEC Panorama. Article. Advanced Microscopy Center receives excellence evaluation. May 2016, No. 722. Page 16.
- Magazine I+D+ i UDEC. Insert on the renovation of CMA BIO BIO. P. 79. No 34, September 2016.
- Magazine PANORAMA UDEC, Advanced Microscopy Center received excellence evaluation. May, 2016, pag. 16
- The latest news. 3D images show how the most aggressive tumors are fed. Wednesday, August 30, 2017.
- Newspaper EL MERCURIO. CMA BIO BIO promotes strategy to open its services to new companies. March 11, 2018
- Conference Inauguration of the 2019 school year, Concepción, Chile. The different types of cell death, an inevitable fate.


Premios y Distinciones

  •   Young Scientific Highlight

    SOCIEDAD DE BIOLOGIA DE CHILE

    Chile, 2001

    Award from the Society of Biology-Bios Chile IGSA

  •   Municipal Science Prize

    ILUSTRE MUNICIPALIDAD DE CONCEPCION

    Chile, 2011

    Award granted by the Municipality of the City of Concepción to the most outstanding Scientists.

  •   Best Image in Cell Biology 2018

    Chilean Society for Cell Biology- XXXII Annual Meeting, October 22-26.

    Chile, 2018

    For many years, the SBCCH has rewarded the best photomicrographers who make important scientific contributions to cell biology in striking pictures. Authors: Germán Osorio, Eder Ramírez, Joanna Tereszczuk, Natalia Saldivia, Gustavo Cerda, Fernando Martínez, Katterine Salazar, Francisco Nualart.

  •   Best Poster Presentation Award

    ISANH international conference 2017. Université Pierre et Marie Curie, Paris.

    Francia, 2017

    Poster presentation: "Vitamin C and neuronal oxidative stress alter mitochondrial and cellular size, tiggering neuronal death". Authors: Ferrada, L; Salazar, K; Nualart F.

  •   Second Best Poster Presentation Award

    Cold Spring Harbor Asia (CSHA) 2018

    China, 2018

    Poster presentation: "Vitamin C sensitizes neural cancer cells to ferroptosis" Authors: Luciano Ferrada and Francisco Nualart

  •   Second place for the Best Image in Cell Biology 2011

    Chilean Society for Cell Biology- XXXII Annual Meeting, October 22-26.

    Chile, 2011

    Poster presentation: "GLIAL SUBVENTRICULAR TUMORS INDUCED IN THE NEUROGENIC NICHE INCREASE GENERATION OF NEUROBLASTS". Authors: Nery Jara and Francisco Nualart.

  •   Third place for the Best Image in Cell Biology 2012

    Chilean Society for Cell Biology- XXVI Annual Meeting 2012

    Chile, 2012

    Poster presentation: "Adult guinea pig brain has a lateral ventricle extention involved in neurogenesis". Authors: Jara, N., Oyarce, K. and Nualart, F.


Tipos de Producción
 

Article (96)

Brain Glucose-Sensing Mechanism and Energy Homeostasis
Metabolic control by dehydroascorbic acid: Questions and controversies in cancer cells
The median eminence as the hypothalamic area involved in rapid transfer of glucose to the brain: functional and cellular mechanisms
Vitamin C controls neuronal necroptosis under oxidative stress
Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells.
Sodium tungstate: Is it a safe option for a chronic disease setting, such as diabetes?
SVCT2 Expression and Function in Reactive Astrocytes Is a Common Event in Different Brain Pathologies.
SVCT2 Is Expressed by Cerebellar Precursor Cells, Which Differentiate into Neurons in Response to Ascorbic Acid.
The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice.
13. Anti-Diabetic Agent Sodium Tungstate Induces the Secretion of Pro- and Anti-Inflammatory Cytokines by Human Kidney Cells.
Aging Selectively Modulates Vitamin C Transporter Expression Patterns in the Kidney.
Apical Polarization of SVCT2 in Apical Radial Glial Cells and Progenitors During Brain Development.
Arachidonic acid triggers [Ca2+]i increases in rat round spermatids by a likely GPR activation, ERK signalling and ER/acidic compartments Ca2+ release.
Endothelial Nitric Oxide Synthase Is Present in Dendritic Spines of Neurons in Primary Cultures.
Oxidative Stress Promotes Doxorubicin-Induced Pgp and BCRP Expression in Colon Cancer Cells Under Hypoxic Conditions.
Structural and functional identification of vasculogenic mimicry in vitro.
Dehydroascorbic Acid Promotes Cell Death in Neurons Under Oxidative Stress: a Protective Role for Astrocytes.
SGLT2 Inhibitors: Glucotoxicity and Tumorigenesis Downstream the Renal Proximal Tubule?
SVCT2 Overexpression in Neuroblastoma Cells Induces Cellular Branching that is Associated with ERK Signaling.
Dehydroascorbic Acid Promotes Cell Death in Neurons Under Oxidative Stress: a Protective Role for Astrocytes
Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength in the epileptic brain
In Vivo Sodium Tungstate Treatment Prevents E-Cadherin Loss Induced by Diabetic Serum in HK-2 Cell Line
Overexpression of muscle glycogen synthase in human diabetic nephropathy.
Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans.
A new rapid kindling variant for induction of cortical epileptogenesis in freely moving rats
Dynamic Localization of Glucokinase and Its Regulatory Protein in Hypothalamic Tanycytes
SVCT2 transporter expression is post-natally induced in cortical neurons and its function is regulated by its short isoform
The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism
Unconventional Neurogenic Niches and Neurogenesis Modulation by Vitamins
Vitamin C Transporters, Recycling and the Bystander Effect in the Nervous System: SVCT2 versus Gluts
Altered expression and localization of insulin receptor in proximal tubule cells from human and rat diabetic kidney
Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation
Dynamic expression of the sodium-vitamin C co-transporters, SVCT1 and SVCT2, during perinatal kidney development
Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells
Human choroid plexus papilloma cells efficiently transport glucose and vitamin C
MCT2 Expression and Lactate Influx in Anorexigenic and Orexigenic Neurons of the Arcuate Nucleus
SVCT2 vitamin C transporter expression in progenitor cells of the postnatal neurogenic niche
The vitamin C transporter SVCT2 is down-regulated during postnatal development of slow skeletal muscles
Cellular distribution of Glut-1 and Glut-5 in benign and malignant human prostate tissue
Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels
Glucose Transporter 1 and Monocarboxylate Transporters 1, 2, and 4 Localization within the Glial Cells of Shark Blood-Brain-Barriers
Typical and atypical stem cells in the brain, vitamin C effect and neuropathology
Expression and Distribution of Facilitative Glucose (GLUTs) and Monocarboxylate/H+ (MCTs) Transporters in Rat Olfactory Epithelia
Insulin Regulates GLUT1-Mediated Glucose Transport in MG-63 Human Osteosarcoma Cells
MCT Expression and Lactate Influx/Efflux in Tanycytes Involved in Glia-Neuron Metabolic Interaction
Up-regulation of the vitamin C transporter SVCT2 upon differentiation and depolarization of myotubes
Expression and localization of an agmatinase-like protein in the rat brain
Glial glucokinase expression in adult and post-natal development of the hypothalamic region
Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1
Glucose transporters in sex steroid hormone related cancer.
Kinin B-1 receptor activation turns on exocytosis of matrix metalloprotease-9 and myeloperoxidase in human neutrophils: involvement of mitogen-activated protein kinase family
Nutritional channels in breast cancer
Stimulation of the bradykinin B-1 receptor induces the proliferation of estrogen-sensitive breast cancer cells and activates the ERK1/2 signaling pathway
The ascorbic acid transporter SVCT2 is expressed in slow-twitch skeletal muscle fibres
The Na+-dependent l-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids
Ascorbic acid participates in a general mechanism for concerted glucose transport inhibition and lactate transport stimulation
Differential distribution of the Sodium-vitamin C cotransporter-1 along the proximal tubule of the mouse and human kidney
Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75
Classical Xenopus laevis progesterone receptor associates to the plasma membrane through its ligand-binding domain
Intracellular ascorbic acid inhibits transport of glucose by neurons, but not by astrocytes
Activation of kinin B-1 receptors induces chemotaxis of human neutrophils
Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: Ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues
Ependymal cell differentiation and GLUT1 expression is a synchronous process in the ventricular wall
Novel expression of liver FBPase in Langerhans islets of human and rat pancreas
Sodium vitamin C cotransporter SVCT2 is expressed in hypothalamic glial cells
The presence of glia stimulates the appearance of glycinergic synaptic transmission in spinal cord neurons
Vitamin C uptake and recycling among normal and tumor cells from the central nervous system
Differential regulation of glucose transporter expression by estrogen and progesterone in Ishikawa endometrial cancer cells
Regulation by insulin and insulin-like growth factor of 2-deoxyglucose uptake in primary ependymal cell cultures.
Stimulated human neutrophils form biologically active kinin peptides from high and low molecular weight kininogens
Broad expression of fructose-1,6-bisphosphatase and phosphoenolpyruvate carboxykinase provide evidence for gluconeogenesis in human tissues other than liver and kidney
Estrogen and progesterone up-regulate glucose transporter expression in ZR-75-1 human breast cancer cells
Hypothalamic ependymal-glial cells express the glucose transporter GLUT2, a protein involved in glucose sensing
Recycling of vitamin C by a bystander effect
Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells
Biosynthesis and molecular biology of the secretory proteins of the subcommissural organ
Early expression of glycine and GABA(A) receptors in developing spinal cord neurons. Effects on neurite outgrowth
Effect of protein kinase C activation on the glycine evoked Cl- current in spinal cord neurons
Elevated expression of glucose transporter-1 in hypothalamic ependymal cells not involved in the formation of the brain-cerebrospinal fluid barrier
High-affinity sodium-vitamin C co-transporters (SVCT) expression in embryonic mouse neurons
Spatial distribution of Reissner's fiber glycoproteins in the filum terminale of the rat and rabbit
Neurite outgrowth in developing mouse spinal cord neurons is modulated by glycine receptors
Expression of the hexose transporters GLUT1 and GLUT2 during the early development of the human brain
Hydrolysis of kininogens by degranulated human neutrophils and analysis of bradykinin as chemotactic factor for cells isolated from peripheral blood.
Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer
Partial sequencing of Reissner's fiber glycoprotein I (RF-Gly I)
Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells
Alpha 1-antitrypsin expression in human thyroid papillary carcinoma
Bovine Reissner's fiber (RF) and the central canal of the spinal cord: An immunocytochemical study using a set of monoclonal antibodies against the RF-glycoproteins
Expression of the fructose transporter GLUT5 in human breast cancer
Analysis of the secretory glycoproteins of the subcommissural organ of the dogfish (Scyliorhinus canicula)
Identification and partial characterization of the secretory glycoproteins of the bovine subcommissural organ-Reissner's fiber complex
Subcommissural organ and cerebrospinal fluid: a biochemical and experimental study.

Conference Poster (71)

Effect of vitamin C recycling during neurospheres differentiation in vitro.
Hyperglycemia modify the cell structure of GLUT2/GLUT6-positive tanycytes from the median eminence.
IIIG9: Analysis of its subcellular localization and the effect of its inhibition in ependymal cells.
Neuronal necroptosis is induced by vitamin C oxidation
Three dimensional structured illumination microscopy (3D-SIM) to evaluate SVCT2 clustering in the neuronal membrane
Vitamin C sensitizes neural cancer cells to ferroptosis
Comparative analysis of vitamin C and vitamin A in stimulating neurite growth in neural progenitors
VITAMIN C TRANSPORTERS EXPRESSION AND DISTRIBUTION IN GLIOBLASTOMA CELLS
SVCT2 Overexpression in Neuroblastoma Cells Induces Cellular Branching that is Associated with ERK Signaling
Ependymal cells differentiation and IIIG9 expression is a synchronous process.
Neurogenesis and lateral ventricular extensión in the adult guinea pig brain.
Structural changes induced for acute hyperglycemia in median eminence tanycytes and vasculature.
Vitamin C deficiency disrupts normal cellular composition within the subventricular zone neurogenic niche
Astroglial hyperexcitability increases the excitatory transmission in epileptic brain
Glial cell distribution and SVCT2 transporter expression in different areas of the adult brain.
SVCT2 transporter expression is postnatally induced in cortical neurons and its function is regulated by hetero-oligomerization
Vitamin C transporters: GLUTs versus SVCTs, conference
Analysis of brain glucose sensing mechanism using adenoviral-mediated inhibition of MCT1 and MCT4 in tanycytes.
Comparative analysis of GLUT1 and SVCCT2 polarization in choroid plexus cells.
MCT2 in brain glucose sensing
Regulation of AA uptake in neuronal precursor cells by a novel short form of SVCT2.
Super-resolution confocal analysis to define the localization and relation of SVCT2 with synaptic proteins in cortical neurons.
Superoxide-dependent uptake of vitamin C in human glioma cells. .
Tanycytes GLUT2 inhibition in vivo affects feeding behavior. IX Reunión de la Sociedad Chilena de Neurociencias. Valparaíso 1-4 de octubre, 2013.
. Neural stem cell differentiation induces a short form of SVCT2
Adult guinea pig brain has a lateral ventricle extention involved in neurogenesis.
Dehydroascorbic acid modulates glycolytic, pentose-phosphate pathway and glutathione activity in cortical neurons
Glucocorticoid receptor localization in the diabetic kidney.
Inhibition of MCT1 through an adenoviral transduction of MCT1 shRNA induces a compensatoy effect.
Lactate affects the expression of orexigenic and anorexigenic neuropeptides in hypothalamic neurons
Myoblasts fusion is induced by a mechanism involving the vitamin C transporter SV C T2 and Wnt3a-dependent signaling
Orexigenic and anorexigenic neurons of the arcuate nucleus express MCT2. 43rd Annual Meeting of American Society for Neurochemistry (ASN). Baltimore, EEUU. (2012).
Role of Sall2 transcription factor in cell proliferation and survival after acute genotoxic injury
Scorbutogenic diet reduces angiogenic activity in a guinea pig model for glioblastoma multiforme
Adenoviral strategies to induce GLUT2 and GLUT6 knock‐down in the tanycytes of the median eminence
Dehydroascorbic acid modulates glycolytic, pentose phosphate pathway and glutathione activity in astrocytes
Glucose Increases Intracellular Free Ca2+ In Tanycytes Via ATP Released Through Connexin 43 Hemichannels.
Glucosensing in hypothalamic tanycytes: signaling through connexin 43 hemichannels.
GLUT1 polarization and function in mouse and human choroid plexus cells
Glycolytic pathway rate and lactate efflux in hypothalamic glial cells and cortical astrocytes
Inhibition of GLUT2 by siRNA adenoviral transduction modulates insulin release in insulinoma cells.
MCT1 Knockdown In Hypothalamic Glial Cells And Their Effect In The Expression Of Neuropeptides That Control Food Intake.
Neural stem cell line C17.2 differentiates into neurons when treated with vitamin C.
Post-natal brain cortex development and SVCT2 expression and function.
The Vitamin C Transporter SVCT2 Is Down-Regulated During Early Post-Natal Development of Slow Skeletal Muscle Fibers.
Acute hyperglycemia induces structural changes in median eminence glial and vasculature
Expression and lactate influx/efflux in hypothalamic glial cells
Glutamate Stimulates vitamin C recycling in astrocyte.
MCT expression and lactate influx/efflux in hypothalamic glial cells
Neurogenesis in a tumor enviroment
SVCT2 lentiviral transduction effect on neuronal branching
SVCT2 polarization and function of vitamin c in radial glial cells.
Vitamin C modulates neural stem cell differentiation.
Vitamin C uptake in glioma cells is associated with microglial intracellular superoxide production

Grant (22)

IIIG9 EXPRESSION AND FUNCTION DURING THE DIFFERENTIATION AND POLARIZATION OF EPENDYMAL CELLS AND IN EPENDYMOMA PROGRESSION
VITAMIN C RECYCLING: FUNCTIONAL EFFECTS IN NEURONAL DIFFERENTIATION AND NECROPTOSIS INDUCTION
Role of Fructose in Prostate Cancer
Research Center for the study of the nervous system: Cell Biology and Biomedical Application.
Generation of autologous articular cartilage for the repair of osteochondral lesions by means of tissue engineering
Vitamin C, differentiation of the nervous system and tumor genesis
Vitamin C and oxidative stress: Mechanism and regulatory factors
Change of glycine receptor properties in spinal neurons

Conference Paper (18)

Cloning and sub-cellular distribution of GK and GKRP in cultures of hypothalamic tanycytes.
Functional characterization of vitamin C in an stem cell model.
GK and GK-RP codistribution in hypothalamic glial cells.
Glial GK expression in adult and post-natal development of hypothalamic region.
Glucose induces changes in cytoarchitecture and vascularization of median eminence.
Glutamate stimulates vitamin C recycling in the astrocyte-neuron interaction.
Hypothalamic glial cells release lactate by monocarboxylate transporters
MCT1 and MCT4 are located in glial cells of hypothalamus
MCT2 is the neuronal transporter in hypothalamus.
Polarization of vitamin C and glucose transporters in choroid plexus cells
Postnatal polarization analysis of choroids plexus.
SVCT2 expression and polarization in radial glial cells
SVCT2 is expressed in type C neurogenic progenitors
SVCT2 lentiviral transduction effects in neuronal branching in vitro.
Hydrolysis of kininogens by degranulated human neutrophils and analysis of bradykinin as chemotactic factor for cells isolated from peripheral blood

Book Review (4)

Vitamin C transporter (SVCT2) distribution in developing and adult brain
Chapter: Vitamin C in skeletal muscle: the importance of transport
Chapter: Vitamin C: Absorption and Reabsorption.
Chapter - Cancer and metabolic adaptation

Nil Class (0)

212
Francisco Nualart

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

28
Maria Garcia

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

16
Katterine Salazar

Associate Professor

Cell Biology

University of Concepcion

Concepción, Chile

16
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

14
Fernando Martinez

Assistant Professor

Cell Biology

Universidad de Concepción

Concepción, Chile

11
Allisson Astuya

profesor asociado

Departamento de Oceanografia de la Universidad de Concepción

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

11
Teresa Caprile

Associate profesor

DPTO. BIOLOGIA CELULAR,

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

10
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

10
Alejandro Yañez

Full professor

Biochemistry and microbiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

9
Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

7
Carola Millán

Profesor

de Ciencias

UNIVERSIDAD ADOLFO IBAÑEZ FACULTAD DE ARTES LIBERALES

Viña del Mar, Chile

6
Juan Tapia

Profesor

UNIVERSIDAD DE TALCA

Talca, Chile

6
Romina Bertinat

Investigador asociado

Centro de Microscopía Avanzada, CMA BIO BIO

Universidad de Concepcion

Concepción, Chile

5
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Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

5
Juan Pablo Henriquez

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

4
Coralia Rivas

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

4
Viviana Ulloa

Profesional Superior

Dirección de Estudios Estratégicos

Universidad de Concepción

Concepción, Chile

4
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Associate Professor

Physiological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

4
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Co-investigador

Ciencia Animal

UNIVERSIDAD DE CONCEPCIÓN

Chillán, Chile

3
Gareth Owen

Profesor Titular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Elena Uribe

Associate Professor

Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

3
INGRID EHRENFELD

ASSOCIATE PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

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Roberto Elizondo

Investigador Post-Doctoral

Universidad de los Andes

Santiago, Chile

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Rafael Burgos

FULL PROFESSOR

PHARMACOLOGY AND MORPHOPHYSIOLOGY

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

3
Maria Poblete

Profesor Auxiliar

Anatomia, Histologia y Patologia

Universidad Austral de Chile

Valdivia, Chile

2
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Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

2
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Investigador

INIA

Osorno, Chile

2
Maite Castro

Professor

Faculty of Sciences

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

2
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Full Professor

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

2
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

1
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Professor

Sciences Faculty

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Carolina Delgado

Encargado de calidad Unidad de Anatomía Patológica

CR Diagnóstico Terapéutico

Hospital Regional Concepción HGGB

Concepcion, Chile

1
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Director

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

1
Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

1
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Nelson Osses

Associated Professor

Institute of Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

1
Sylvain Marcellini

Associate Professor

Department of Cell biology

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Felipe Zúñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Estefania Tarifeño

Postdoctoral Researcher

Centro de Biotecnología

Universidad de Concepción

Concepción, Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Vania Figueroa

Profesor Asistente

Instituto de Ciencias de la Salud

Universidad de O’Higgins

Rancagua, Chile

1
Juan Orellana

Assistant Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Paula Sotomayor

Investigador

Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Reyes

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

1
Ilona Concha

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Fernando Delgado

Associate Professor

Division of Medicine

Universidad Catolica del Maule

Talca, Chile

1
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Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Marcelo Bustamante

Director

Basisc Sciences

UNIVERSIDAD CATÓLICA DE LA SANTÍSIMA CONCEPCIÓN

CONCEPCIÓN, Chile

1
Nelson Osses

Profesor Titular

Instituto de Química

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Marco Fuenzalida

Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
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profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

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Director

Center for Biomedical Research

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

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Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Victor Castro

Profesor Asistente

Departamento de Biología

UNIVERSIDAD DE CHILE

Ñuñoa, Chile

1
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Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

1
Magdalena Cuevas

Profesor Asistente

Departamento de Fisiología

Universidad de Concepción

Concepción, Chile

1
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Investigador

Biología celular

Universidad de Concepción

Concepcion, Chile

1
Pabla Aguirre

Asistente de investigación

Biología

Universidad de Chile

Santiago, Chile