Man

Lorena Del Pilar Garcia Nannig

Assistant Professor

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Enfermedades crónicas y su asociacion con Inflamacion y estres oxidativo (hipetension, diabetes, entre otras) Estudio quimico y farmaco-toxicologico de productos naturales y de vias transduccionales asociadas a inflamacion

Educación

  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2005

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Quimicas y Farmaceuticas

    Santiago, Chile

    Enero 1995 - A la fecha

Formación de Capital Humano


Undergraduate THESIS STUDENTS (last 5 years): 14
Pharmaceutical Chemist, University of Chile: Sandra Espinoza, Grace Cordero, Daniela Jara, Ma Jose Quepil, Ma Magdalena Penna, Rafael Lopez, Elia Becerra. Biochemist, University of Chile: Veronica Gonzalez. Pharmaceutical Chemist, P Catholic University of Chile: Natalia Montt, Leticia Perez, Mario Navarro, Amalia Garcia, Valeria Tapia. Biotechnology, Mayor University: María Teresa Gomez.

PhD THESIS STUDENTS (last 5 years): 5
PhD in Biochemistry, University of Chile: Ariel Díaz. PhD in Pharmacology, University of Chile: Claudio Humeres, Pía Boza. PhD in Pharmaceutical Science, University of Chile: Claudia Muñoz, Marcelo Peña

POST-GRADUATE LECTURE COURSES (Chile). Lecturer in 2 post-graduate courses of the University of Chile (Biochemist and Macromolecular Function, and Strategies for Investigation of Bioactive Natural Products).



Tipos de Producción
 

Article (45)

Polymorphisms in the RAC1 Gene Are Associated With Hypertension Risk Factors in a Chilean Pediatric Population
EPAC expression and function in cardiac fibroblasts and myofibroblasts
TGF-beta 1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways
Dexmedetomidine preconditioning activates pro-survival kinases and attenuates regional ischemia/reperfusion injury in rat heart
Impaired cardiac autophagy in patients developing postoperative atrial fibrillation
Mitochondria, Myocardial Remodeling, and Cardiovascular Disease
Relationship between mechanical and metabolic dyssynchrony with left bundle branch block: Evaluation by 18-fluorodeoxyglucose positron emission tomography in patients with non-ischemic heart failure
Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability
Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure
Mayor actividad de rho kinasa en leucocitos circulantes se asocia a estrés oxidativo y rigidez arterial en hipertensos diabéticos
Systemic Oxidative Stress and Endothelial Dysfunction is Associated With an Attenuated Acute Vascular Response to Inhaled Prostanoid in Pulmonary Artery Hypertension Patients
Systemic vascular cell adhesion molecule-1 predicts the occurrence of post-operative atrial fibrillation
The role of uric acid in heart failure
The role of uric acid in heart failure Ácido úrico: Una molécula con acciones paradójicas en la insuficiencia cardiaca
Xanthine-oxidase inhibitors and statins in chronic heart failure: Effects on vascular and functional parameters
Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes
Heart energy metabolism and its role in the treatment of heart failure Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca
Increased levels of oxidative stress, subclinical inflammation, and myocardial fibrosis markers in primary aldosteronism patients
Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide
Niveles aumentados de estrés oxidativo se asocian a disfunción endotelial periférica y respuesta vascular pulmonar disminuida frente a vasodilatadores en pacientes con hipertensión pulmonar
Comparative Study of CSF Neurofilaments in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis and Other Neurological Disorders
El tratamiento con atorvastatina reduce la actividad de xantina-oxidasa unida al endotelio en pacientes con insuficiencia cardíaca crónica: ¿Un posible nuevo efecto pleiotrópico?
Application of capillary electrophoresis for the identification of Atlantic salmon and rainbow trout under raw and heat treatment.
Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica
Inflammation and endothelial dysfunction in patients with chronic heart failure
Inflammation and endothelial dysfunction in patients with chronic heart failure Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica
Interacción entre los polimorfismos del receptor ß1 y ß2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica
Interactions between beta(1) and beta(2) adrenergic receptor polymorphisms as risk factors for chronic heart failure
Interactions between ß 1 and ß 2 adrenergic receptor polymorphisms as risk factors for chronic heart failure Interacción entre los polimorfismos del receptor ß 1 y ß 2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica
Microtubule proteins and their post-translational forms in the cerebrospinal fluid of patients with paraparesis associated with HTLV-I infection and in SH-SY5Y cells: An in vitro model of HTLV-I-induced disease
Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor
Pleiotropic effects of atorvastatin in heart failure: Role in oxidative stress, inflammation, endothelial function, and exercise capacity
Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure
Trophic factors in cerebrospinal fluid and spinal cord of patients with tropical spastic paraparesis, HIV, and Creutzfeldt-Jakob disease
Potato tuber isoapyrases: Substrate specificity, affinity labeling, and proteolytic susceptibility
Extracellular matrix protein expression in cerebrospinal fluid from patients with tropical spastic paraparesis associated with HTLV-I and Creutzfeldt-Jakob disease
Matrix metalloproteinase profile in patients with Creuztfeldt-Jakob disease
TIMPs and MMPs expression in CSF from patients with TSP/HAM
ATPase and ADPase activities in synovial membrane of equine metacarpophalangeal joint
Human placental ecto-enzymes: Studies on theplasma membrane anchorage and effect of inhibitors of ATP-metabolizing enzymes
Kinetic characteristics of nucleoside mono-, di- and triphosphatase activities of the periplasmic 5'-nucleotidase of Escherichia coli
ATP-diphosphohydrolase activity in rat renal microvillar membranes and vascular tissue
ATP-diphosphophydrolase activity in rat heart tissue
Characterization of ATP-diphosphohydrolase from rat mammary gland
Comparison of the biochemical properties, regulation and function of ATP-diphosphohydrolase from human placenta and rat kidney

Review (4)

Influence of glucose metabolism on vascular smooth muscle cell proliferation
Regulation of cardiac autophagy by insulin-like growth factor 1
Heart energy metabolism and its role in the treatment of heart failure
Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca

Abstract (3)

Increased Oxidative Stress Correlates With Pulmonary Vascular Response to Vasodilators in Pulmonary Artery Hypertension Patients
Matrix metalloproteinases profile in patients with Creuztfeldt-Jakob disease
NGF and FGF-2 in CSF and in spinal cord from TSP/HAM patients.

Comunicacion Breve (1)

Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca

Letter (1)

Uric acid, xanthine oxidase and heart failure: Unresolved issues

Nil Class (0)

74
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

24
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

23
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

15
Hugo Verdejo

Profesor Asistente

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

13
Rosemarie Mellado

Jefe de carrera / Académica

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

10
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

8
Jorge Jalil

FULL PROFESSOR

ENFS CARDIOVASCULARES

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE MEDICINA

Santiago, Chile

5
Luigi Gabrielli

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

5
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

5
Rodrigo Troncoso

Assistant professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

3
Samuel Cordova

ESCUELA DE MEDICINA, PONTIFICA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Pablo Aránguiz

Postdoctorado

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

3
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Gina Sánchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

2
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

2
Ramon Corbalan

Director

Division of Cardiovascular Diseases

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

2
Bernardo Krause

Assistant Professor

Division of Pediatrics

CENTRO DE INVESTIGACIONES MÉDICAS, ESCUELA DE MEDICINA, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Andrea del Campo

Posdoctorado

Laboratorio de FIsiología del músculo

Universidad de Chile

Santiago, Chile

2
Juan Carlos Quintana

Médico nuclear

Radiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Cristian Carvajal

Assistant Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Eduardo Aranda

Biochemist

Hematology

P. UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Sergio González

FACULTAD DE MEDICINA. PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

1
CARLOS LAGOS

Profesor Asistente

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
Sandra Solari

Profesor Asociado

Departamento Laboratorios Clinicos - Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
lorena mosso

profesor asociado

endocrinologia

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Roberto Bravo

Investigador Postdoctoral

Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile

Santiago, Chile

1
Victoria Espinosa

Academica titular, Vicedecana de Investigación FACIMED

Facultad de Ciencias Medicas

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile