Man

Eugenia Morselli

Profesor Asistente de Planta Ordinaria

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

Líneas de Investigación


Autophagy; Metabolism; Obesity

Educación

  •  Cellular and Molecular Biology, UNIVERSITÉ PARIS-SUD, PARIS XI. Francia, 2010
  •  Medical Biotechnology, UNIVERSITÀ DEGLI STUDI DI MODENA E REGGIO EMILIA. Italia, 2007

Experiencia Académica

  •   Profesor Asistente de Planta Ordinaria Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Enero 2014 - A la fecha

Formación de Capital Humano


Since the beginning of my career as assistant professor at the Pontificia Universidad Católica de Chile (July 2014) I have been actively involved in the training of students in the laboratory.
Student mentoring and teaching are detailed below:
STUDENTS

Doctoral program in Biological Sciences of the Pontificia Universidad Católica de Chile, specialization in Physiology.

1. Maria Paz Hernandez “PALMITIC ACID-MEDIATED G PROTEIN–COUPLED RECEPTOR 40 (GPR40) ACTIVATION INHIBITS AUTOPHAGY AND PROMOTES INFLAMMATION IN HYPOTHALAMIC NEURONS”.
She joined the laboratory in march 2015, she performed the two investigation units required by her study program in the first year and she defended her qualifying exam in June 2016.

2. Lilian Toledo “GPR40 AS MEDIATOR OF PALMITIC-ACID INDUCED INFLAMMATION AND INSULIN RESISTANCE IN HYPOTHALAMIC NEURONS”.
She joined the laboratory in march 2016 and she will defend her qualifying exam in August 2017.

Biochemistry, biology and college undergraduate programs of the Pontificia Universidad Católica de Chile.

1. Germán Arenas (4th year Biology Student). He performed a research unit in the laboratory entitled “Involvementof the protein GPR40 in hypothalamic autophagy”.

2. Javier Novoa (3rd year Biochemistry Student). He performed a research unit in the laboratory entitled “Exposure to high fat diet inhibits hypothalamic autophagy”.

3. Ana María Velásquez Alvarado (3rd year College Student). She performed a research unit in the laboratory entitled “ Effect of high fat diet on GPR40 hypothalamic expression”.

4. Camila Solar (3rd year Biochemistry Student). She performed a research unit in the laboratory entitled “Function of the protein GPR40 in neuronal autophagy”.

School of medicine of the Pontificia Universidad Católica de Chile.

Diana Fuentes Castillo. She joined the laboratory as recipient of a felloship financed by the school of medicine for medical students to get laboratory experience. Her project is entitled “Involvement of hypothalamic GPR40 in saturated fatty acids-mediated autophagy and inflammation”.

Genetics and Biotechnology program of the Universidad Nacional Mayor de San Marcos – Perú.

Marion Fernández Berrocal. She is performing her undergraduate thesis project entitled “Preparation of rat primary hypothalamic neurons to determine if palmitic acid modulates autophagy".


Difusión y Transferencia


• Interview on the Newspaper “El Mercurio” “Looking for a way to enhance the beneficial effects of estrogens in men”, July 22nd, 2015.
• Coffee with the Doctor (activity realized during the Biochemistry congress, Santiago 2015), July 23rd, 2015.
• Interview to “Canal 13” (TV program “Teletrece AM”) regarding the results published by the World Health Organization on the correlation between meat consumption and cancer, October 27th, 2015.
• Interview on the Newspaper “El Mercurio” “Vegans need a better balance in their diet and require vitamin supplies”, March 23rd, 2016.
• Interview on the Newspaper “El Mercurio” “Intermittent fasting or eating reduced amounts of food have a positive effect on health and state of mind” 4 de May 4th, 2016.

ORGANIZATION OF WORKSHOPS AND SIMPOSIA

- Organizer of the mini-simposium “Round Table: “Autophagy: Expanding the Knowledge”, Facultad de Ciencias Biologicas, Pontificia Universidad Católica de Chile, Abate Molina, Santiago, Chile, September 21st, 2015.

- Organizer of the Symposium “Key Roles Of Autophagy In Chronic Diseases”, (XXXVIII Reunión Anual de la Sociedad de Bioquímica y Biología Molecular de Chile), Puerto Varas, Chile, Septiembre 25th 2015.

- Co-organizer of the Workshop “Autophagy: Physiological and Pathological Roles”, Facultad de Cs. Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile, November 23rd and 24th, 2016. Workshop financed by the “International Cenre for Genetic Engineering and Biotechnology (ICGEB)”.


Premios y Distinciones

  •   Keystone Symposia Travel Award

    Keystone Symposia

    Estados Unidos, 2014

    Travel award to assist and give a short oral communication to theKeystone Conference "Obesity: A Multisystems Perspective (J2)" Fairmont Hotel Vancouver, CANADA, January, 2014.


Tipos de Producción
 

Article (33)

Autophagy and oxidative stress in non-communicable diseases: a matter of the inflammatory state?
Impact of estrogens and estrogen receptor-alpha in brain lipid metabolism
Polycystin-2-dependent control of cardiomyocyte autophagy
Hyperosmotic stress stimulates autophagy via polycystin-2
New Roles of the Primary Cilium in Autophagy
Sex Hormones and Cardiometabolic Health: Role of Estrogen and Estrogen Receptors
The effects of oestrogens and their receptors on cardiometabolic health
Regulation of cardiomyocyte autophagy by calcium
Sex and Gender: Critical Variables in Pre-Clinical and Clinical Medical Research
Sexually dimorphic brain fatty acid composition in low and high fat diet-fed mice
Maternal high-fat diet is associated with impaired fetal lung development
ER? upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue
Hypothalamic PGC-1 alpha Protects Against High-Fat Diet Exposure by Regulating ER alpha
Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A
Inhibition of autophagy by TAB2 and TAB3
Longevity-relevant regulation of autophagy at the level of the acetylproteome
p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
Defective autophagy control by the p53 rheostat in cancer.
miR-181a and miR-630 Regulate Cisplatin-Induced Cancer Cell Death
Mitochondrial gateways to cancer
The IKK complex contributes to the induction of autophagy
Upregulation of nuclear-encoded mitochondrial LON protease in HAART-treated HIV-positive patients with lipodystrophy: implications for the pathogenesis of the disease
Viral strategies for the evasion of immunogenic cell death.
Nutlin kills cancer cells via mitochondrial p53
Targeting post-mitochondrial effectors of apoptosis for neuroprotection
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
Mechanisms of p53-mediated mitochondrial membrane permeabilization
Mutant p53 protein localized in the cytoplasm inhibits autophagy
p53 represses autophagy in a cell cycle-dependent fashion
Regulation of autophagy by cytoplasmic p53
Targeting p53 to mitochondria for cancer therapy
Viral Control of Mitochondrial Apoptosis

Dtp Import/Article (28)

Autophagy and Its Impact on Neurodegenerative Diseases=> New Roles for TDP-43 and C9orf72.
A sexually dimorphic hypothalamic response to chronic high-fat diet consumption.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Sex and Gender: Critical Variables in Pre-Clinical and Clinical Medical Research.
AGPAT2 deficiency impairs adipogenic differentiation in primary cultured preadipocytes in a non-autophagy or apoptosis dependent mechanism.
Estrogen, astrocytes and the neuroendocrine control of metabolism.
Direct molecular interactions between Beclin 1 and the canonical NFκB activation pathway.
Evaluation of rapamycin-induced cell death.
Phosphoproteomic analysis of cells treated with longevity-related autophagy inducers.
Prognostic impact of vitamin B6 metabolism in lung cancer.
BH3 mimetics activate multiple pro-autophagic pathways.
Mitochondrial liaisons of p53.
Oncosuppressive functions of autophagy.
Autophagy regulation by p53.
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy.
IKK connects autophagy to major stress pathways.
The life span-prolonging effect of sirtuin-1 is mediated by autophagy.
Viral strategies for the evasion of immunogenic cell death.
Anti- and pro-tumor functions of autophagy.
Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol.
Control of autophagy by oncogenes and tumor suppressor genes.
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.
Stimulation of autophagy by the p53 target gene Sestrin2
A dual role of p53 in the control of autophagy.
Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death.
Life, death and burial: multifaceted impact of autophagy.
Senescence, apoptosis or autophagy? When a damaged cell must decide its path--a mini-review.
Chronic High Fat Diet Consumption Impairs Metabolic Health of Male Mice.

Grant (5)

International Network for the Study of Autophagy
Mechanisms of Autophagy in Obesity
Polycystin2-Beclin-1: a novel protein complex in autophagy regulation

Book Section (3)

Loss of autophagy in hypothalamic neurons may be involved in the pathogenesis of obesity
Aging
Mutant p53 Located in the Cytoplasm Inhibits Autophagy

Review (1)

A sexually dimorphic hypothalamic response to chronic high-fat diet consumption
42
Eugenia Morselli

Profesor Asistente de Planta Ordinaria

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

16
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

6
Eugenia Morselli

Assistant professor

Pontificia Universidad Católica

Santiago, Chile

4
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Roberto Bravo

Investigador Postdoctoral

Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile

Santiago, Chile