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Juan Carlos Saez Carreño

Professor

Universidad de Valparaiso

Valparaíso, Chile

Regulation and function of gap junctions and hemichannels formed by connexins or pannexins in cells of the brain and skeletal muscles under normal and pathological conditions.

Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1979
Neurociencias, ALBERT EINSTEIN COLLEGE OF MEDICINE. Estados Unidos, 1986

Instructor Full Time

UNIVERSIDAD DE CONCEPCION

Biological Sciences

Concepcion, Chile

1979 - 1983
Assistant Professor Full Time

ALBERT EINSTEIN COLLEGE OF MEDICINE

New York, Estados Unidos

1987 - 1993
Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Biological Sciences

Santiago, Chile

1993 - 1994
Associate Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Biological Sciences

Santiago, Chile

1995 - 2002
Full Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Biological Sciences

Santiago, Chile

2003 - 2017
Full Professor Full Time

UNIVERSIDAD DE VALPARAISO

Facultad de Ciencias

Valparaiso, Chile

2017 - A la fecha

INstructor Full Time

Universidad de Concepcion

Concepcion, Chile

1979 - 1983
Assistant Professor Full Time

Albert Instein College of Medicine

New York, Estados Unidos

1987 - 1993
Assistant Professor Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

1993 - 1994
Associate Professor Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

1994 - 2002
Professor Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2003 - A la fecha
Professor Full Time

Universidad de Valparaiso

Valparaiso, Chile

2017 - A la fecha

7 postoral fellows
-Dr. Iván Bravo. Involvement of connexin hemichannles expressed by glial cells in depression. (2018-present).
-Dr. Iván Barría. Role of connexin-based channels expressed by glia in the cochlea under inflammatory conditions. (2018-present)
-Dr. Rosalba Escamilla. Role of hemichannels in oligodendrocytes of neuroinflammatory diseases.(2014-present).
-2014-2017. Dra. Elisa Balboa. Proyecto Fondecyt. Relevancia del estrés oxidativo, la disfunción mitocondrial y la expresión de conexinas en la inducción de atrofia muscular por
dexamatasona.
-Dr. Carlos Puebla. FONDECYT. (3130662). "Regulation glucose transport through its specific transporters and hemichannels by essential fatty acids in the small intestine".
-Dr. Adam Aguirre. FONDECYT. (3130632)."Involvement of hemichannels in glia pre-activation by auditory stress to inflammation promoted by poly (I:C) and consequences on
neuronal arborization and survival".
-Dr. Jose Luis Vega. FONDECYT.(3120006). “Regulation of connexin-43 hemichannels properties by PKC, PKA and MAP kinases”.

34 graduate students and 6 undergraduate students
- 2020 Presente. Claudia García. Doctorado en Neurociencias, Instituto de Neurociencias. Universidad de Valparaíso. Mejoramiento del tratamiento actual de la epilepsia
considerando la neuroinflamación mediada por hemicanales
- 2012-2020. Ximena López. Doctor Ciencias Fisiológicas, PUC. Papel de hemicanales formadospor Panexina 1 en la inhibición de la activación de linfocitos T CD4+ por
adenosina
- 2011-present. Bruno Cisterna.Doctor Ciencias Fisiológicas, PUC. "Role of connexin hemichannels in muscle atrophy induced by denervation".
- 2012-present. Elsa Fritz,(Co-mentor with Dr. Jorge Campusano) Doctor Ciencias Fisiológicas, PUC. "Role of innexins on the coordinated circadian of behavior in Drosophila
melanogaster".
- 2013-present. Gonzalo Gomez, Doctor Ciencias Fisiológicas, PUC."The R hoA/ROCK pathway regulates the connexin43 hemichannel and gap junctional channel activity in
angiotensin-induce kidney injury.
- 2013-present. Dusan Recordon. (co-mentor with Dr. Gareth Owen). Doctor Ciencias Fisiológicas, PUC. "Purinergic signaling in the vasculogenesis-like process".
- 2009-present. Carola Marturana, Doctor Ciencias Fisiológicas, PUC. "Involvement of pannexin1 hemichannels of oligodendrocytes in amyelinization during prenatal stress".
- 20111-present Anibal Vargas, Doctor Ciencias Fisiológicas, PUC. "Involvement of connexin hemichanels in muscle atrophy induced by cachexia".
- 2009-present. Paloma Hacha, Doctor Ciencias Fisiológicas, PUC. Involvement of hemichannels in the degranulation response induced by immunoglobulin E in murine mast
cells”
- 2012-2014. Carolina Urrutia, (co-mentor with DR. Victoria Velarde). Master in Science: Free Radicals and Biomedicine”. The University of Vaparaíso. "Activation of
hemichannels
formed by connexins promotes Ca2+ influx, oxidative stress, and cell death, which is prevented by antioxidant agents that block hemichannels”.
- 2009-2013. Maximiliano Rovegno. (Co-mentor with Dra. Rommy von Benhardi). Doctorado en Ciencias Médicas, PUC. “Activation of inflammation in astrocytes induced by
ATP release via connexin hemichannels in an in vitro model of brain trauma".
- 2009-2013. Raúl Lagos Cabré. (Co-mentor with Dr. Ricardo Moreno). Doctorado en Ciencias Fisiológicas, PUCC. “Modulation of the ADAM protein family by xenostrogens
induces apoptosis in male germinal cells”.
- 2009-presente. Daniela Salas. (Co-mentor with Dr. Sergio Lavandero). Doctorado en Bioquímica, Universidad de Chile. “Regulation of Cx43 hemichannels by metabolic
stress”.
- 2008-2012. Pablo J. Sáez. Candidato a Doctor Ciencias Fisiológicas, PUC. Regulation and funtion of hemichannels and gap junction channels at the interaction between
dendritic cell and T lymphocytes.
- 2009-2012. Vania Figueroa. (Co-mentor with Dr. Agustín Martínez). Doctorado en Neurociencias, Universidad de Valparaíso. Activation of hemichannels formed by hCx26
and hPanx1 under physiologic and pathologic conditions and its possible role in the etiopatognesis of defness.
- 2008-2012. Luis A. Cea. Doctor Ciencias Fisiológicas, PUC. The activity controls the levels of connexins 39, 43 and 45 in rat skeletal muscles.
- 2008-2011. Kenji Shoji. Doctor Ciencias Fisiológicas, PUC. T-lymphocytes present Panx1 channels coupled to P2X7 receptor that mediate ATP-induced cell death induced
by extracellular ATP.
- 2008-presente. Romina Hernández (Co-tutor con Dra. M.V. Velarde). Candidato a Doctor Ciencias Fisiologicas, PUC. Effect of boldine in diabetic nephropaty in rats.
- 2008-2010. Juan A. Orellana. Doctor en Ciencias Biológicas, mención Ciencias Fisiológicas, PUC. Role and regulation of astroglial channels formed by connexin43 in
neuronal death induced by hypoxia in high glucose: potentiation by neurodegenerative agents.
- 2005-2010. Manuel A. Riquelme. Doctor en Ciencias Biológicas, mención Ciencias Fisiológicas, PUC. Role of panneixn1 hemichannels and extracellular ATP in myogenic
commitment and potentiation of muscle contraction in adult muscles.
- 2003-2008. Carolina Gatica de la Puente. Doctor en Ciencias Biológicas, mención Ciencias Fisiológicas, PUC. Role of hemichannels and gap junction channels in neuronal
differentiation and myogenic commitment acquisition in cell lines.
- 2005-2008. Helmuth Sánchez. Doctor en Ciencias Biológicas, mención Ciencias Fisiológicas, PUC. Involvement of connexin32 based channels in cell responses of two in
vitro models of ischemia-reperfusion.
- 2007-2008. Kurt A. Schalper. Doctor en Ciencias Médicas, PUC. Modulation of connexin hemichannel functional state by different physicochemical stimuli.
- 2003-2005. Mauricio Retamal. Doctor en Ciencias Biológicas, mención Ciencias Fisiológicas. PUC. Hemichannels formed by connexin43 are sensitive to redox changes.
- 2003-2005. Mauricio Garré. (Co-Director con la Dr. Veronica Abudara). Maestría en Biología, opción Neurociencias. PEDECIBA, Uruguay.Effects of fibroblast growth factor
FGF-1 on the intercellular communication medoated by gap junction channels on the neurotoxic phenotype of spinal astrocytes
- 2001-2005. (Co-Director con el Dr. M. Boric) Loreto P. Véliz. Doctor en Ciencias Biológicas, mención Ciencias Fisiológicas, PUC. Expression and function of gap junctions
between leukocytes and endothelial cells during inflammation.
- 1999-2003. Sra. Liliana Corvalán. Doctor en Ciencias Biológicas, mención Ciencias Fisiológicas, PUC. “Gap junctions in contacts dendrict cell-T cell contacts”.
- 1999-2003. Dr. Jorge Contreras. Doctor en Ciencias Biológicas, mención Ciencias Fisiológicas, PUC. “Biophysical properties and mechanism of action of hemichannels
formed by connexin43: possible participation in cell death induced by ischemia”.
- 1999-2004. Roberto Araya. Doctor en Ciencias Biológicas, mención Ciencias Fisiológicas, PUC. Papel de los receptores purinérgicos y de las uniones en hendidura en el
proceso de diferenciación del músculo esquelético.
- 1998-2001. Dr. Eliseo A. Eugenín. Doctor en Ciencias Biológicas, mención Ciencias Fisiológicas, PUC. “Uniones en hendidura (UH) entre macrófagos: identificación de
conexinas, regulación de su expresión y su función en procesos metabólicos y celulares”.
- 1997-2000. Dr. María C. Brañes. Doctor en Ciencias Biológicas, mención, Biología Celular y Molecular. PUC. “Polymorphonuclear cells and endothelial cells form homo end
heterocellular gap junctions regulated by proinflammatory agents”.
- 1996-1998. Dr. Hernán González. Doctor en Ciencias Médicas. PUC. “Effect of endotoxemia on hepatic gap junctions”.
- 1996-1999. Dr. Agustín Martínez. Doctor en Ciencias Biológicas, mención Ciencias Fisiológicas. PUC. “In vitro regulation of glial gap junctions by inflammatory conditions”.
- 1989-1992. Dr. Viviana M. Berthoud, Department of Neuroscience, Albert Einstein College of Medicine, Nueva York, E.E.U.U. Ph.D. in Sciences. “Regulation of Gap
Junctions”.

24 Undergradute thesis
- 20178-2019. Catalina A. Ascencio Barría. “Análisis de la expresión y estado funcional de conexinas en cáncer de próstata”. (Cotutoría con Dr. Alejandro Godoy).
- 2017. Camila Aravena. Biochemist, PUC Role of glial hemichannels in epilepsy.
- 2015-2016. Fijiko Saveedra. “Participación de los hemicanales formados por conexinas en la atrofia
de los músculos esqueléticos rápidos adultos producida por denervación”. Bioquímico. Pontificia
Universidad Católica de Valparaiso.
- 2013-2014 Angelica Benvenuto.Biochemist, PUC. "Characterization of hemichannels and gap junction channels formed by connexina43 y pannexin 1 en adipocytes"
- 2011. (Co-mentor with Dr. Xavier Figueroa) Mauricio A. Lillo. Biochemist, PUC. Involvement hemichannels formed by connexins or pannexins in NO transport cross the
cell membrane in the vascular wall.
- 2009. Anibal Vargas. Lic. Biología, PUC. Characterization of antimycin A as an inhibitor of hemichannels formed by connexins.
- 2007-2009. (Co-mentor with Dr. Sergio Lavandero). Daniela P. Salas. Biochemist, Universidad de Chile. Hemichannels formed by connexins in volume regulation in
myocardiocytes exposed to hypoosmotic stress.
- 2009. Paola Soto. Biologist, PUC. Study on channels formed by connexin32 in a cell line derived from oligodendrocytes.
- 2008. Marlene Arismendi, Industrial Chemist, UTEM, Purification and biological activity of compounds derived from Boldo on channels formed by connexins.
- 2008. Diego Hernández, Biologist, PUC. Regulation of astroglial and neuronal channels formed by connexins in neurodegenerative processes.
- 2009. Natalia Vega, Biochemist, PUC. Regulation of cell membrane permeability by phosphorylation of hemichannels formed by connexin43 via protein kinase C (PKC).
- 2008. Paloma Harcha, Biologist, PUC. D2SC1 cells express functional hemichannels formed by pannexina1.
- 2006. Ariel Orellana. Biologist, PUC. The acquisition of myogenic commitment of reserve C2C12 cells requires activation of P2X receptors.
- 2006. Pablo J. Sáez, Biologist, PUC. ATP and TNF-? induce formation gap junction channels in microglia.
- 2006. Kenji Shoji, Biologist, PUC. The redox sensor of hemichannels formed by connexin43 is located in the carboxyl terminus of the protein subunit.
- 2005. Juan Andrés Orellana, Biologist, PUC. Chlorpromazine inhibits intercellular communication mediated by gap junctions in Gn-11 cells and astrocytes.
- 2005. Constanza J. Cortés, Biologist, PUC. Opening of Cx43 hemichannels in mediated by oxidative mechanisms in astrocytes”.
- 2005. Nicolás Palacios, Biologist, PUC. Modulation of the functional state of connexin-based channels by sexual hormones and tamoxifen in a cells line derived from human
breast cancer.
- 2002-2003. Manuel Riquelme-Biochemist, PUC. P2X receptors and connexin-based channels are needed for acquisition of myogenic commitment.
- 1998-1999. Patricio Orio-Biochemist, Universidad de Chile. Molecular characterization and functional gap junctions Express by Peripherals human lymphocytes.
- 1997. Alejandro Sepúlveda-Biochemist, Univ. Austral de Chile. Gap junctions between antigen-presenting cells and T cells: characterization and regulation of connexins.
- 1997. Eliseo Eugenín-Biochemist, Univ. Austral de Chile. Regulation of glycogen stores by norepinephrine in rat pineal gland: role of gap junctions.
- 1994-1995. Francisco Scheihing- Biochemist, Universidad Católica de Valparaíso. Effect of leptocarpin on gap junctions of epithelial cell lines.
- 1996. Erwin Strahsburger-Biochemist, Univ. Austral de Chile. Regulation of gap junctional Communications in astroglial cells of the pineal gland.

3 workshops and three meeting symposia.

Scopus

Elsevier Editorial

Chile, 2008

Highest productivity and impact among Chilean Scientist in Pharmacology, Biochemistry, Cell Biology and Molecular Biology
Member of the National Academy of Science USA

UNIVERSIDAD DE VALPARAISO

Estados Unidos, 2019

Member of the National Academy of Science USA
Member of the Latin American Academy of Science

UNIVERSIDAD DE VALPARAISO

Chile, 2017

Cell Biology and Molecular Biology


Contribution of large-pore channels to inflammation induced by microorganisms Vega, Jose L.; Gutierrez, Camila; Rojas, Mauro; Guiza, Juan; Saez, Juan C. Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)
Expression of KID syndromic mutation Cx26S17F produces hyperactive hemichannels in supporting cells of the organ of Corti Abbott, Ana C.; Garcia, Isaac E.; Villanelo, Felipe; Flores-Munoz, Carolina; Ceriani, Ricardo; Maripillan, Jaime; Novoa-Molina, Joel; Figueroa-Cares, Cindel; Perez-Acle, Tomas; Saez, Juan C.; Sanchez, Helmuth A.; Martinez, Agustin D. Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)
Share Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons. Arredondo C, Cefaliello C, Dyrda A, Jury N, Martinez P, Díaz I, Amaro A, Tran H, Morales D, Pertusa M, Stoica L, Fritz E, Corvalán D, Abarzúa S, Méndez-Ruette M, Fernández P, Rojas F, Kumar MS, Aguilar R, Almeida S, Weiss A, Bustos FJ, González-Nilo F, Ot Article ISI NEURON (2022)
Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties. Palacios-Prado N, Soto PA, López X, Choi EJ, Marquez-Miranda V, Rojas M, Duarte Y, Lee J, González-Nilo FD, Sáez JC. Article ISI Proc Natl Acad Sci USA (2022)
Oxidative Stress, Inflammation and Connexin Hemichannels in Muscular Dystrophies. González-Jamett A, Vásquez W, Cifuentes-Riveros G, Martínez-Pando R, Sáez JC, Cárdenas AM. Article ISI Biomedicines (2022)
Contribution of non-selective membrane channels and receptors in epilepsy. García-Rodríguez C, Bravo-Tobar ID, Duarte Y, Barrio LC, Sáez JC Article ISI PHARMACOLOGY AND THERAPEUTICS (2022)
TNF-α Plus IL-1β Induces Opposite Regulation of Cx43 Hemichannels and Gap Junctions in Mesangial Cells through a RhoA/ROCK-Dependent Pathway. Lucero CM, Marambio-Ruiz L, Balmazabal J, Prieto-Villalobos J, León M, Fernández P, Orellana JA, Velarde V, Sáez JC, Gómez GI. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy. Guo A, Zhang H, Li H, Chiu A, García-Rodríguez C, Lagos CF, Sáez JC, Lau CG. Article ISI Proc Natl Acad Sci USA (2022)
Share A Short-Term Sucrose Diet Impacts Cell Proliferation of Neural Precursors in the Adult Hypothalamus. Recabal A, López S, Salgado M, Palma A, Obregón AM, Elizondo-Vega R, Sáez JC, García-Robles MÁ. Article ISI NUTRIENTS (2022)
Share Unnexins: Homologs of innexin proteins in Trypanosomatidae parasites. Güiza J, García A, Arriagada J, Gutiérrez C, González J, Márquez-Miranda V, Alegría-Arcos M, Duarte Y, Rojas M, González-Nilo F, Sáez JC, Vega JL. Article ISI JOURNAL OF CELLULAR PHYSIOLOGY (2022)
A Short-Term Sucrose Diet Impacts Cell Proliferation of Neural Precursors in the Adult Hypothalamus Recabal, Antonia; Lopez, Sergio; Salgado, Magdiel; Palma, Alejandra; Obregon, Ana M.; Elizondo-Vega, Roberto; Saez, Juan C.; Garcia-Robles, Maria A. Article ISI NUTRIENTS (2022)
Contribution of non-selective membrane channels and receptors in epilepsy Garcia-Rodriguez, Claudia; Bravo-Tobar, Ivan D.; Duarte, Yorley; Barrio, Luis C.; Saez, Juan C. Article ISI PHARMACOLOGY THERAPEUTICS (2022)
Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties Palacios-Prado, Nicolas; Soto, Paola A.; Lopez, Ximena; Choi, Eun Ju; Marquez-Miranda, Valeria; Rojas, Maximiliano; Duarte, Yorley; Lee, Jinu; Gonzalez-Nilo, Fernando D.; Saez, Juan C. Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons Arredondo, Cristian; Cefaliello, Carolina; Dyrda, Agnieszka; Jury, Nur; Martinez, Pablo; Diaz, Ivan; Amaro, Armando; Tran, Helene; Morales, Danna; Pertusa, Maria; Stoica, Lorelei; Fritz, Elsa; Corvalan, Daniela; Abarzua, Sebastian; Mendez-Ruette, Maxs; Fernandez, Paola; Rojas, Fabiola; Kumar, Meenakshi Sundaram; Aguilar, Rodrigo; Almeida, Sandra; Weiss, Alexandra; Bustos, Fernando J.; Gonzalez-Nilo, Fernando; Otero, Carolina; Tevy, Maria Florencia; Bosco, Daryl A.; Saez, Juan C.; Kahne, Thilo; Gao, Fen-Biao; Berry, James D.; Nicholson, Katharine; Sena-Esteves, Miguel; Madrid, Rodolfo; Varela, Diego; Montecino, Martin; Brown, Robert H.; van Zundert, Brigitte Article ISI NEURON (2022)
Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy Guo, Anni; Zhang, Huiqi; Li, Huanhuan; Chiu, Arthur; Garcia-Rodriguez, Claudia; Lagos, Carlos F.; Saez, Juan C.; Lau, Chunyue Geoffrey Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
Oxidative Stress, Inflammation and Connexin Hemichannels in Muscular Dystrophies Gonzalez-Jamett, Arlek; Vasquez, Walter; Cifuentes-Riveros, Gabriela; Martinez-Pando, Rafaela; Saez, Juan C.; Cardenas, Ana M. Article ISI BIOMEDICINES (2022)
TNF-alpha Plus IL-1 beta Induces Opposite Regulation of Cx43 Hemichannels and Gap Junctions in Mesangial Cells through a RhoA/ROCK-Dependent Pathway Lucero, Claudia M.; Marambio-Ruiz, Lucas; Balmazabal, Javiera; Prieto-Villalobos, Juan; Leon, Marcelo; Fernandez, Paola; Orellana, Juan A.; Velarde, Victoria; Saez, Juan C.; Gomez, Gonzalo, I Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Unnexins: Homologs of innexin proteins in Trypanosomatidae parasites Guiza, Juan; Garcia, Anibal; Arriagada, Javiera; Gutierrez, Camila; Gonzalez, Jorge; Marquez-Miranda, Valeria; Alegria-Arcos, Melissa; Duarte, Yorley; Rojas, Maximiliano; Gonzalez-Nilo, Fernando; Saez, Juan C.; Vega, Jose L. Article ISI JOURNAL OF CELLULAR PHYSIOLOGY (2022)
Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer's Disease, ALS, and Harmful Stress Conditions. Harcha PA, Garcés P, Arredondo C, Fernández G, Sáez JC, van Zundert B. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Share Anti-parasitic drugs modulate the non-selective channels formed by connexins or pannexins. Güiza J, Arriagada J, Rodríguez L, Gutiérrez C, Duarte Y, Sáez JC, Vega JL. Article ISI Biochim Biophys Acta Mol Basis Dis (2021)
Share Long-term effects of stress resilience: Hippocampal neuroinflammation and behavioral approach in male rats Bravo-Tobar ID, Fernández P, Sáez JC, Dagnino-Subiabre A Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (2021)
Stretch-Induced Activation of Pannexin 1 Channels Can Be Prevented by PKA-Dependent Phosphorylation. López X, Escamilla R, Fernández P, Duarte Y, González-Nilo F, Palacios-Prado N, Martinez AD, Sáez JC. Article ISI Int J Mol Sci. (2021)
Purinergic signaling in tanycytes and its contribution to nutritional sensing. Salgado M, García-Robles MÁ, Sáez JC Article ISI PURINERGIC SIGNALLING (2021)
Wang Y, Su Y, Yu G, Wang X, Chen X, Yu B, Cheng Y, Li R, Sáez JC, Yi C, Xiao L, Niu J. Article ISI Adv Sci (Weinh) (2021)
A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII. López X, Palacios-Prado N, Güiza J, Escamilla R, Fernández P, Vega JL, Rojas M, Marquez-Miranda V, Chamorro E, Cárdenas AM, Maldifassi MC, Martínez AD, Duarte Y, González-Nilo FD, Sáez JC. Article ISI Proc Nat Acad Sci USA (2021)
Identification of Cx45 as a Major Component of GJs in HeLa Cells. Choi EJ, Palacios-Prado N, Sáez JC, Lee J. Article ISI Biomolecules (2021)
A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII Lopez, Ximena; Palacios-Prado, Nicolas; Guiza, Juan; Escamilla, Rosalba; Fernandez, Paola; Vega, Jose L.; Rojas, Maximiliano; Marquez-Miranda, Valeria; Chamorro, Eduardo; Cardenas, Ana M.; Maldifassi, Maria Constanza; Martinez, Agustin D.; Duarte, Yorley; Gonzalez-Nilo, Fernando D.; Saez, Juan C. Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
Anti-parasitic drugs modulate the non-selective channels formed by connexins or pannexins Guiza, Juan; Arriagada, Javiera; Rodriguez, Luis; Gutierrez, Camila; Duarte, Yorley; Saez, Juan C.; Vega, Jose L. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)
Glial Connexins and Pannexins in the Healthy and Diseased Brain. Giaume C, Leybaert L, Naus CC, Sáez JC. Article PHYSIOLOGICAL REVIEWS (2021)
Long-term effects of stress resilience: Hippocampal neuroinflammation and behavioral approach in male rats Bravo-Tobar, Ivan D.; Fernandez, Paola; Saez, Juan C.; Dagnino-Subiabre, Alexies Article ISI JOURNAL OF NEUROSCIENCE RESEARCH (2021)
Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer's Disease, ALS, and Harmful Stress Conditions Harcha, Paloma A.; Garces, Polett; Arredondo, Cristian; Fernandez, German; Saez, Juan C.; van Zundert, Brigitte Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Purinergic signaling in tanycytes and its contribution to nutritional sensing Salgado, Magdiel; Garcia-Robles, Maria a.; Saez, Juan C. Article ISI PURINERGIC SIGNALLING (2021)
Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress Wang, Yuxin; Su, Yixun; Yu, Guangdan; Wang, Xiaorui; Chen, Xiaoying; Yu, Bin; Cheng, Yijun; Li, Rui; Saez, Juan C.; Yi, Chenju; Xiao, Lan; Niu, Jianqin Article ISI ADVANCED SCIENCE (2021)
The FGF2-induced tanycyte proliferation involves a connexin 43 hemichannel/purinergic-dependent pathway Recabal, Antonia; Fernandez, Paola; Lopez, Sergio; Barahona, Maria J.; Ordenes, Patricio; Palma, Alejandra; Elizondo-Vega, Roberto; Farkas, Carlos; Uribe, Amparo; Caprile, Teresa; Saez, Juan C.; Garcia-Robles, Maria A. Article ISI JOURNAL OF NEUROCHEMISTRY (2021)
The FGF2-induced tanycyte proliferation involves a connexin 43 hemichannel/purinergic-dependent pathway. Recabal A, Fernández P, López S, Barahona MJ, Ordenes P, Palma A, Elizondo-Vega R, Farkas C, Uribe A, Caprile T, Sáez JC, García-Robles MA Article ISI J Neurochem. (2021)
Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation Cisterna, Bruno A.; Vargas, Aníbal A.; Puebla, Carlos; Fernández, Paola; Escamilla, Rosalba; Lagos, Carlos F; Matus, María F.; Vilos, Cristian; Cea, Luis A.; Barnafi, Esteban; Gaete, Hugo; Escobar, Daniel F.; Cardozo, Christopher P.; Sáez, Juan C. Article SCOPUS Nature Communications (2020)
Blockade of Hemichannels Normalizes the Differentiation Fate of Myoblasts and Features of Skeletal Muscles from Dysferlin-Deficient Mice Cea, Luis A.; Fernández, Gabriela; Arias-Bravo, Guisselle; Castillo-Ruiz, Mario; Escamilla, Rosalba; Brañes, María C.; Sáez, Juan C. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Confirmation of Connexin45 Underlying Weak Gap Junctional Intercellular Coupling in HeLa Cells Choi, Eun Ju; Palacios-Prado, Nicolas; Saez, Juan C.; Lee, Jinu Article ISI Biomolecules (2020)
Connexin 43 deletion in astrocytes promotes CNS remyelination by modulating local inflammation Li T.; Niu J.; Yu G.; Ezan P.; Yi C.; Wang X.; Koulakoff A.; Gao, X.; Chen X.; SÃ¡ez J.C.; Giaume C.; Xiao L. Article ISI SCOPUS GLIA (2020)
Glial connexins and pannexins in the healthy and diseased brain Giaume, Christian BA; Naus, Christian C.; Saez, Juan Carlos; Leybaert, Luc Article ISI PHYSIOLOGICAL REVIEWS (2020)
Interferon-gamma and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage Saez, Juan C.; Contreras-Duarte, Susana; Labra, Valeria C.; Santibanez, Cristian A.; Mellado, Luis A.; Inostroza, Carla A.; Alvear, Tanhia F.; Retamal, Mauricio A.; Velarde, Victoria; Orellana, Juan A. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)
Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage. Sáez JC, Contreras-Duarte S, Labra VC, Santibañez CA, Mellado LA, Inostroza CA, Alvear TF, Retamal MA, Velarde V, Orellana JA. Article ISI Biochim Biophys Acta Mol Cell Res (2020)
Myofibers deficient in connexins 43 and 45 expression protect mice from skeletal muscle and systemic dysfunction promoted by a dysferlin mutation Fernández, Gabriela; Arias-Bravo, Guisselle; Bevilacqua, Jorge A.; Castillo-Ruiz, Mario; Caviedes, Pablo; Sáez, Juan C.; Cea, Luis A. Article ISI Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2020)
Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species Sáez, Juan C.; Vargas, Aníbal A.; Hernández, Diego E.; Ortiz, Fernando C.; Giaume, Christian; Orellana, Juan A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Stretch-Induced Activation of Pannexin 1 Channels Can Be Prevented by PKA-Dependent Phosphorylation Lopez, Ximena; Escamilla, Rosalba; Fernandez, Paola; Duarte, Yorley; Gonzalez-Nilo, Fernando; Palacios-Prado, Nicolas; Martinez, Agustin D.; Saez, Juan C. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
The FGF2‐induced tanycyte proliferation involves a connexin 43 hemichannel/purinergic‐dependent pathway Recabal, Antonia; Fernández, Paola; López, Sergio; Barahona, María José; Ordenes, Patricio; Alejandra, Palma; Elizondo?Vega, Roberto; Farkas, Carlos; Uribe, Amparo; Caprile, Teresa; Sáez, Juan C.; García?Robles, María A Article ISI JOURNAL OF NEUROCHEMISTRY (2020)
Vitamin E Blocks Connexin Hemichannels and Prevents Deleterious Effects of Glucocorticoid Treatment on Skeletal Muscles Balboa, Elisa; Saavedra, Fujiko; Cea, Luis A.; Ramírez, Valeria; Escamilla, Rosalba; Vargas, Aníbal A.; Regueira, Tomás; Sáez, Juan C. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
De novo expression of functional connexins 43 and 45 hemichannels increases sarcolemmal permeability of skeletal myofibers during endotoxemia Cea, Luis A.; Balboa, Elisa; Vargas, Anibal A.; Puebla, Carlos; Branes, Maria C.; Escamilla, Rosalba; Regueira, Tomas; Saez, Juan C Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)
Gap junctions coordinate the propagation of glycogenolysis induced by norepinephrine in the pineal gland Eugenin E.A.; Valdebenito S.; Gorska A.M.; MartÃnez A.D.; Bitran M.; SÃ¡ez J.C. Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2019)
Pannexin-1 Channels Are Essential for Mast Cell Degranulation Triggered During Type I Hypersensitivity Reactions Harcha P.A.; LÃ³pez X.; SÃ¡ez P.J.; FernÃ¡ndez P.; BarrÃa I.; MartÃnez A.D.; SÃ¡ez J.C. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes Harcha PA, López X, Sáez PJ, Fernández P, Barría I, Martínez AD, Sáez JC Article (2019)
Role of a RhoA/ROCK-Dependent Pathway on Renal Connexin43 Regulation in the Angiotensin II-Induced Renal Damage Gomez, Gonzalo I.; Velarde, Victoria; Saez, Juan C Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Role of calcium permeable channels in dendritic cell migration Sáez PJ, Sáez JC, Lennon-Duménil AM, Vargas P Article ISI Curr Opin Immunol (2018)
Angiotensin II-Induced Mesangial Cell Damage Is Preceded by Cell Membrane Permeabilization Due to Upregulation of Non-Selective Channels Gomez, Gonzalo, I; Fernandez, Paola; Velarde, Victoria; Saez, Juan C Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Astroglial Ca 2+ -dependent hyperexcitability requires p2y 1 purinergic receptors and pannexin-1 channel activation in a chronic model of epilepsy Wellmann M.; Álvarez-Ferradas C.; Maturana C.J.; Sáez J.C.; Bonansco C. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2018)
Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function Sáez, Juan C.; Contreras-Duarte, Susana; Gómez, Gonzalo I.; Labra, Valeria C.; Santibañez, Cristian A.; Gajardo-Gómez, Rosario; Avendaño, Beatriz C.; Díaz, Esteban F.; Montero, Trinidad D.; Velarde, Victoria; Orellana, Juan A. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
Role of calcium permeable channels in dendritic cell migration Saez, Pablo J.; Saez, Juan C; Lennon-Dumenil, Ana-Maria; Vargas, Pablo Article ISI SCOPUS CURRENT OPINION IN IMMUNOLOGY (2018)
SEPSIS-INDUCED CHANNELOPATHY IN SKELETAL MUSCLES IS ASSOCIATED WITH EXPRESSION OF NON-SELECTIVE CHANNELS Balboa, E; Saavedra-Leiva, F; Cea, LA; Vargas AA; Ramirez, V; Escamilla, R; Saez, JC; Regueira, T Article ISI Shock (2018)
Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes Barria, Ivan; Guiza, Juan; Cifuentes, Fredi; Zamorano, Pedro; Saez, Juan C; Gonzalez, Jorge; Vega, Jose L. Article ISI SCOPUS AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2018)
ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X7 receptors Sáez PJ, Vargas P, Shoji KF, Harcha PA, Lennon-Duménil AM, Sáez JC Article ISI SCIENCE SIGNALING (2017)
ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X(7) receptors Saez, PJ; Vargas, P; Shoji, KF; Harcha, PA; Lennon-Dumenil, AM; Saez, JC Article ISI SCOPUS Science Signaling (2017)
Cannabinoids Prevent the Amyloid beta-Induced Activation of Astroglial Hemichannels: A Neuroprotective Mechanism Gajardo-Gómez, R.; Labra, V.C.; Maturana, C.J.; Shoji, K.F.; Santibañez, C.A.; Sáez, J.C.; Giaume, C.; Orellana, J.A. Article ISI SCOPUS GLIA (2017)
Connexins and pannexins in Alzheimer's disease. Giaume C, Sáez JC; Song W, Leybaert L Article Neurosci Lett (2017)
High Glucocorticoid Levels During Gestation Activate the Inflammasome in Hippocampal Oligodendrocytes of the Offspring Maturana C.J.; Aguirre A.; Sáez J.C. Article ISI SCOPUS Developmental Neurobiology (2017)
Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease Yi C.; Ezan P.; Fernández P.; Schmitt J.; Sáez J.C.; Giaume C.; Koulakoff A. Article ISI SCOPUS GLIA (2017)
On Biophysical Properties and Sensitivity to Gap Junction Blockers of Connexin 39 Hemichannels Expressed in HeLa Cells Vargas, AA.; Cisterna, BA.; Saavedra-Leiva, F.; Urrutia, C. ; Cea, LA.; Vielma, AH.; Gutierrez-Maldonado, SE.; Martin, AJ.; Pareja-Barrueto, C.; Escalona, Y.; Schmachtenberg, O.; Lagos, CF.; Perez-Acle, T.; Sáez, JC. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2017)
Regulation of Connexin-Based Channels by Fatty Acids Puebla, Carlos; Retamal, Mauricio A.; Acuña, Rodrigo; Sáez, Juan C. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2017)
A soluble activin receptor IIB fails to prevent muscle atrophy in a mouse model of spinal cord injury Graham Z.A.; Collier, L; Peng, Y.; Sáez, J.C.; Bauman W.A.; Qin W.; Cardozo C.P. Article ISI SCOPUS Journal of Neurotrauma (2016)
Connexin hemichannels explain the ionic imbalance and lead to atrophy in denervated skeletal muscles Cisterna, Bruno A.; Vargas, An?bal A.; Puebla, Carlos; S?ez, Juan C. Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)
Connexin Hemichannels=> Methods for Dye Uptake and Leakage. Johnson RG, Le HC; Evenson K, Loberg SW; Myslajek TM, Prabhu A; Manley AM, O'Shea C; Grunenwald H, Haddican M; Fitzgerald PM, Robinson T; Cisterna BA, Sáez JC; Liu TF, Laird DW Article J Membr Biol (2016)
Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels. Cea LA, Balboa E; Puebla C, Vargas AA; Cisterna BA, Escamilla R; Regueira T, Sáez JC. Article Biochim Biophys Acta. (2016)
Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels. Cea LA, Balboa E, Puebla C, Vargas AA, Cisterna BA, Escamilla R, Regueira T, Sáez JC. Article Biochim Biophys Acta (2016)
Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels. Cea LA, Balboa E; Puebla C, Vargas AA; Cisterna BA, Escamilla R; Regueira T, Sáez JC. Article Biochim Biophys Acta. Molecular Basis of Disease (2016)
Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis Cea L.A.; Puebla, C; Cisterna B.A.; Escamilla, R; Vargas A.A.; Frank, M; Martínez-Montero P.; Prior C.; Molano J.; Esteban-Rodríguez I.; Pascual, I.; Gallano, P; Lorenzo G.; Pian H.; Barrio L.C.; Willecke K.; Sáez, J.C. Article ISI SCOPUS CELLULAR AND MOLECULAR LIFE SCIENCES (2016)
Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism Puebla, C; Cisterna B.A.; Salas D.P.; Delgado-Lopez, F; Lampe P.D.; Sáez, J.C. Article ISI SCOPUS Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (2016)
The absence of dysferlin induces the expression of functional connexin-based hemichannels in human myotubes Cea, Luis A.; Bevilacqua, Jorge A.; Arriagada, Christian; Cárdenas, Ana María; Bigot, Anne; Mouly, Vincent; Sáez, Juan C.; Caviedes, Pablo Article ISI SCOPUS BMC CELL BIOLOGY (2016)
Connexin43 Hemichannels Mediate Secondary Cellular Damage Spread from the Trauma Zone to Distal Zones in Astrocyte Monolayers Rovegno M.; Soto Pa; Sáez PJ; Naus, CC; Sáez JC; von Bernhardi R. Article ISI SCOPUS GLIA (2015)
Hemichannels Are Required for Amyloid beta-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice Harcha PA; Vargas A.; Yi, CJ; Koulakoff, AA; Giaume C.; Sáez JC Article ISI SCOPUS Journal of Neuroscience (2015)
Keratitis-Ichthyosis-Deafness Syndrome-Associated Cx26 Mutants Produce Nonfunctional Gap Junctions but Hyperactive Hemichannels When Co-Expressed With Wild Type Cx43 Garcia, IE; Maripillán J; Jara O.; Ceriani, R.; Palacios-Muñoz A; Ramachandran J; Olivero P.; Perez-Acle, T; González C; Sáez JC; Contreras, JE; Martínez AD Article ISI SCOPUS Journal of Investigative Dermatology (2015)
Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells Talaverón R.; Fernández P.; Escamilla, R; Pastor A.M.; Matarredona E.R.; Sáez, J.C. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2015)
Restraint stress increases hemichannel activity in hippocampal glial cells and neurons Orellana, Juan A.; Moraga-Amaro, Rodrigo; Díaz-Galarce, Raúl; Rojas, Sebastián; Maturana, Carola J.; Stehberg, Jimmy; Sáez, Juan C. Article ISI SCOPUS Frontiers in Cellular Neuroscience (2015)
Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition Salas, D.; Puebla, C; Lampe, PD; Lavandero S.; Sáez JC Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2015)
Characterization of a Novel Water Pocket Inside the Human Cx26 Hemichannel Structure Araya-Secchi R; Perez-Acle, T; Kang, SG; Huynh T.; Bernardin A; Escalona Y.; Garate, JA; Martínez AD; Garcia, IE; Sáez JC; Zhou R. Article ISI SCOPUS BIOPHYSICAL JOURNAL (2014)
Extracellular gentamicin reduces the activity of con nexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells Figueroa V.A.; Retamal M.A.; Cea L.A.; Salas J.D.; Vargas A.A.; Verdugo C.A.; Jara O.; Martinez A.D.; Sáez, J.C. Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca(2+) signaling in HeLa cells. Figueroa VA, Retamal MA, Cea LA, Salas JD, Vargas AA, Verdugo CA, Jara O, Martínez AD, Sáez JC. Article Scopus Front Cell Neurosci (2014)
Gap Junction Intercellular Communication Mediated by Connexin43 in Astrocytes Is Essential for Their Resistance to Oxidative Stress Le H.T.; Sin W.C.; Lozinsky, S; Bechberger, J; Vega, J. L.; Guo X.Q.; Sáez, J.C.; Naus C.C. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Hemichannels; from the molecule to the function Retamal, MA.; Sáez JC Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2014)
Opening of pannexin- and con nexin-based channels increases the excitability of nodose ganglion sensory neurons Retamal, Mauricio A; Alcayaga, Julio; Verdugo, Christian A.; Bultynck, Geert; Leybaert, Luc; Sáez, Pablo J.; Fernández, Ricardo; León, Luis E.; Sáez, Juan C. Article ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Pannexin 1 channels in skeletal muscles Cea, LA; Riquelme, MA; Vargas AA; Urrutia, C; Sáez JC Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2014)
Pannexin 1 channels: new actors in the regulation of catecholamine release from adrenal chromaffin cells Momboisse F.; Olivares, MJ; Baez-Matus X; Guerra MJ; Flores-Munoz, C; Sáez JC; Martínez AD; Cárdenas AM Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Pannexin 1 channels: new actors in the regulation of catecholamine release from adrenal chromaffin cells. Momboisse F, Olivares MJ, Báez-Matus X, Guerra MJ, Flores-Muñoz C, Sáez Juan C, Martínez Agustin D, Cárdenas AM. Article Front Cell Neurosci (2014)
Pannexin 1 regulates bidirectional hippocampal synaptic plasticity in adult mice Ardiles, AO, Flores C, Ahumada J, Monyer H, Cárdenas, AM, Palacios AG, Muñoz-Carvajal P, Sáez JC, Fuenzalida M, Martínez AD. Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Pannexin1 channels act downstream of P2X(7) receptors in ATP-induced murine T-cell death Shoji KF, Sáez PJ, Harcha PA, Aguila HL, Sáez JC. Article ISI SCOPUS CHANNELS (2014)
ATP is Required and Advances Cytokine-Induced Gap Junction Formation in Microglia In Vitro Sáez PJ, Shoji KF, Retamal MA, Harcha PA, Ramírez G, Jiang JX, von Bernhardi R, Sáez JC. Article ISI SCOPUS Mediators of Inflammation (2013)
Boldine Prevents Renal Alterations in Diabetic Rats Hernandez-Salinas, R; Vielma AZ; Arismendi, MN; Boric, MP; Sáez JC; Velarde, V Article ISI SCOPUS Journal of Diabetes Research (2013)
Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia Kozoriz MG, Lai S, Vega JL, Sáez JC, Sin WC, Bechberger JF, Naus CC. Article ISI SCOPUS Neuropharmacology (2013)
De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy Cea, LA; Cisterna, BA; Puebla, C; Frank, M; Figueroa, XF; Cardozo C.; Willecke K.; Latorre R.; Sáez JC Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2013)
Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels Figueroa XF, Lillo MA, Gaete PS, Riquelme MA, Sáez JC Article ISI SCOPUS Neuropharmacology (2013)
Disruption in Connexin-Based Communication Is Associated with Intracellular Ca2+ Signal Alterations in Astrocytes from Niemann-Pick Type C Mice Sáez PJ; Orellana, JA; Vega-Riveros, N; Figueroa, VA; Hernández DE; Castro, JF; Klein, AD; Jiang JX; Zanlungo S.; Sáez JC Article ISI SCOPUS PLOS ONE (2013)
FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and the purinergic receptor P2X(7) Aguirre A.; Shoji, KF; Sáez JC; Henríquez M; Quest, AFG Article ISI SCOPUS Journal of Cellular Physiology (2013)
Gap Junctions in Antigen-Presenting Cells Sáez PJ; Shoji, KF; Sáez JC Article ISI CONNEXIN CELL COMMUNICATION CHANNELS: ROLES IN THE IMMUNE SYSTEM AND IMMUNOPATHOLOGY (2013)
HIV increases the release of dickkopf-1 protein from human astrocytes by a Cx43 hemichannel-dependent mechanism. Orellana JA, Sáez JC, Bennett MV, Berman JW, Morgello S, Eugenin EA Article Scopus J Neurochem. (2013)
Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation Giaume C.; Froger, N; Orellana, JA; Retamal, M.; Sáez JC Article ISI CONNEXIN CELL COMMUNICATION CHANNELS: ROLES IN THE IMMUNE SYSTEM AND IMMUNOPATHOLOGY (2013)
Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca2+-dependent pathway Figueroa, V.; Sáez PJ; Salas JD; Salas, D.; Jara O.; Martínez AD; Sáez JC; Retamal, MA. Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)
Pannexin1 hemichannels are critical for HIV infection of human primary CD4(+) T lymphocytes Orellana, JA; Velasquez S.; Williams, DW; Sáez JC; Berman, JW; Eugenin, EA Article ISI SCOPUS Journal of Leukocyte Biology (2013)
The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels Riquelme MA, Cea LA, Vega JL, Boric MP, Monyer H, Bennett MV, Frank M, Willecke K, Sáez JC. Article ISI SCOPUS Neuropharmacology (2013)
Connexin 36 is Expressed in Beta and Connexins 26 and 32 in Acinar Cells at the End of the Secondary Transition of Mouse Pancreatic Development and Increase During Fetal and Perinatal Life Perez-Armendariz E.M.; Cruz-Miguel L.; Coronel-Cruz C.; Esparza-Aguilar M.; Pinzon-Estrada E.; Rancano-Camacho E.; Zacarias-Climaco G.; Olivares P.F.; Espinosa A.M.; Becker, I; Sáez, J.C.; Berumen J.; Perez-Palacios G. Article ISI SCOPUS Anatomical Record (2012)
Connexin and pannexin hemichannels in inflammatory responses of glia and neurons. Bennett MV, Garré JM, Orellana JA, Bukauskas FF, Nedergaard M, Sáez JC. Article Brain Res. (2012)
Connexin-based channels in astrocytes: How to study their properties Giaume C.; Orellana J.A.; Abudara, V; Sáez, J.C. Article SCOPUS Methods in Molecular Biology (2012)
Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function Jara O.; Acuña R.; Garcia I.E.; Maripillán J; Figueroa, V.; Sáez, J.C.; Araya-Secchi R.; Lagos, C. F.; Perez-Acle, T; Berthoud V.M.; Beyer E.C.; Martinez A.D. Article ISI SCOPUS MOLECULAR BIOLOGY OF THE CELL (2012)
Glial hemichannels and their involvement in aging and neurodegenerative diseases Orellana, JA; von Bernhardi R.; Giaume C.; Sáez JC Article ISI SCOPUS Reviews in the Neurosciences (2012)
Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels Orellana J.A.; Sáez P.J.; Cortes-Campos, C; Elizondo R.J.; Shoji, K.F.; Contreras-Duarte, S; Figueroa, V.; Velarde, V; Jiang J.X.; Nualart, F.; Sáez, J.C.; García M.A. Article ISI SCOPUS GLIA (2012)
Permeation of Calcium through Purified Connexin 26 Hemichannels Fiori M.C.; Figueroa, V.; Zoghbi M.E.; Sáez, J.C.; Reuss L.; Altenberg G.A. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels Orellana J.A.; Schalper K.A.; Figueroa, V.; SANCHEZ, H.A.; Sáez, J.C. Article ISI SCOPUS Advances in Experimental Medicine and Biology (2012)
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala Stehberg, J; Moraga-Amaro, R; Salazar C.; Becerra, A; Echeverria, C.; Orellana J.A.; Bultynck G.; Ponsaerts, R; Leybaert, L; Simon F.; Sáez, J.C.; Retamal M.A. Article ISI SCOPUS FASEB Journal (2012)
Amyloid beta-Induced Death in Neurons Involves Glial and Neuronal Hemichannels Orellana, JA; Shoji, KF; Abudara, V; Ezan P.; Amigou, E; Sáez PJ; Jiang JX; Naus, CC; Sáez JC; Giaume C. Article ISI SCOPUS Journal of Neuroscience (2011)
ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels Orellana, JA; Froger, N; Ezan P.; Jiang JX; BENNETT, MVL; Naus, CC; Giaume C.; Sáez JC Article ISI SCOPUS Journal of Neurochemistry (2011)
Boldina disminuye la apoptosis miocárdica post isquemia reperfusión en la rata López, René; Arismendi, Marlene; Sáez, Juan Carlos; Godoy, Ivan; Ocaranza, Maria Paz Article SCIELO Revista chilena de cardiología (2011)
Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species Orellana, JA; Diaz, E.; Schalper, KA; Vargas AA; BENNETT, MVL; Sáez JC Article ISI SCOPUS Biochemical and Biophysical Research Communications (2011)
Hemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions Orellana, JA; Figueroa, XF; Sanchez HA; Contreras-Duarte, S; Velarde, V; Sáez JC Article ISI SCOPUS CNS and Neurological Disorders - Drug Targets (2011)
Cell membrane permeabilization via connexin-hemichannels in living and dying cells. Sáez, J.C., Schalper, K. A., Retamal, M.A., Orellana, J.A, Shoji, K.F., and Bennett, M.V.L Article Exp. Cell Res. (2010)
Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization Schalper, KA; Sanchez HA; Lee, SC; Altenberg, GA; Nathanson, MH; Sáez JC Article ISI SCOPUS American Journal of Physiology - Cell Physiology (2010)
Connexin43 is a pH-gated plasma membrane calcium channel. Schalper K.A., Lee S-C; Altenberg G.A., Nathanson M.H. and Sáez J.C. Article Amer. J. Physiol. (2010)
FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels Garre, JM; Retamal, MA.; Cassina, P; Barbeito, L; Bukauskas, FF; Sáez JC; BENNETT, MVL; Abudara, V Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2010)
Hypoxia in High Glucose Followed by Reoxygenation in Normal Glucose Reduces the Viability of Cortical Astrocytes Through Increased Permeability of Connexin 43 Hemichannels Orellana, JA; Hernández DE; Ezan P.; Velarde, V; BENNETT, MVL; Giaume C.; Sáez JC Article ISI SCOPUS GLIA (2010)
Inhibition of Cx43 hemichannels activated by pro-inflammatory treatment exhibited a neuroprotective effect against NMDA excitotocixity. Froger N., Orellana J.A., Amigou E., Kozoriz M.G., Naus C.C, Sáez J.C. and Giaume C. Article Mol. Cell Neurosci. (2010)
Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective Froger, N; Orellana, JA; Calvo, CF; Amigou, E; Kozoriz, MG; Naus, CC; Sáez JC; Giaume C. Article ISI SCOPUS Molecular and Cellular Neuroscience (2010)
ATP Released by Electrical Stimuli Elicits Calcium Transients and Gene Expression in Skeletal Muscle Buvinic, S.; Almarza G.; Bustamante, M; Casas M.; Lopez, J.; Riquelme M.; Sáez JC; Huidobro-Toro, JP; Jaimovich E. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments Froger, N; Orellana, JA; Cohen-Salmon, M; Ezan P.; Amigou, E; Sáez JC; Giaume C. Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2009)
Dysfunctions of the Diffusional Membrane Pathways Mediated Hemichannels in Inherited and Acquired Human Diseases Schalper, Kurt A.; Orellana, Juan A.; Berthoud, Viviana M.; Saez, Juan C Article ISI CURRENT VASCULAR PHARMACOLOGY (2009)
Gap Junctions at the Dendritic Cell-T Cell Interface Are Key Elements for Antigen-Dependent T Cell Activation Elgueta R.; Tobar, JA; Shoji, KF; De Calisto, J.; Kalergis, AM; Bono, MR.; Rosemblatt, M.; Sáez JC Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2009)
Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells Sanchez HA; Orellana, JA; Verselis, VK; Sáez JC Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neuro-egeneration. Orellana, J.A., Sáez, P.J., Shoji, K.F., Schalper, K.A., Palacios-Prado, N., Velarde, V., Giaume, C., Bennett, M.V.L. and Sáez, J.C. Article Antioxidants & Redox Signaling (2009)
Astrocytes as connexin-dependent signaling cells for local blood flow regulation. Sáez, J.C. Article Amer. J. Physiol. (2008)
Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+](i) responses Schalper, KA; Palacios-Prado, N; Retamal, MA.; Shoji, KF; Martínez AD; Sáez JC Article ISI SCOPUS MOLECULAR BIOLOGY OF THE CELL (2008)
Currently used methods for identification and characterization of hemichannels Schalper, KA; Palacios-Prado, N; Orellana, JA; Sáez JC Article ISI SCOPUS CELL COMMUNICATION AND ADHESION (2008)
Functional role of gap junctions in cytokine-induced leukocyte adhesion to endothelium in vivo Véliz LP; Gonzalez, FG; Duling, BR; Sáez JC; Boric, MP Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)
The connexin hemichannel composition determines the FGF-1-induced membrane permeability and free Ca2+i responses. Schalper, K.A., Palacios-Prado, N., Retamal, M.A., Shoji, K.F., Martínez A.D. and Sáez. J.C. Article Mol. Biol. Cell (2008)
Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia Retamal, MA.; Froger, N; Palacios-Prado, N; Ezan P.; Sáez PJ; Sáez JC; Giaume C. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2007)
Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells Mendoza-Naranjo, A; Sáez PJ; Johansson, CC; Ramirez M.; Mandakovic, D; Pereda, C; López MN; Kiessling R.; Sáez JC; SALAZAR ONFRAY F Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2007)
Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro Eugenin, EA; González HE; Sanchez HA; Branes, MC; Sáez JC Article ISI SCOPUS CELLULAR IMMUNOLOGY (2007)
Injury of skeletal muscle and specific cytokines induce the expression of gap junction channels in mouse dendritic cells Corvalan, LA; Araya, R; Branes, MC; Sáez PJ; Kalergis, AM; Tobar, JA; Theis, M; Willecke K.; Sáez JC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2007)
Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential Retamal, MA.; Schalper, KA; Shoji, KF; BENNETT, MVL; Sáez JC Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Chlorpromazine reduces the intercellular communication via gap junctions in mammalian cells Orellana, JA; Palacios-Prado, N; Sáez JC Article ISI SCOPUS TOXICOLOGY AND APPLIED PHARMACOLOGY (2006)
S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents Retamal, MA.; Cortes, CJ; Reuss L.; BENNETT, MVL; Sáez JC Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43 Araya, R; Eckardt, D; Maxeiner, S; Kruger, O; Theis, M; Willecke K.; Sáez JC Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2005)
HISTAMINE REDUCES GAP JUNCTIONAL COMMUNICATION OF HUMAN TONSIL HIGH ENDOTHELIAL CELLS IN CULTURE Saez, Juan; Rosemblatt, Mario; Martinez, Agustin; Garces, Gladys; Figueroa, Xavier; Boric, Mauricio; Alviña, Karina Article MICROVASCULAR RESEARCH (2004)
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue Contreras, JE; Sanchez HA; Véliz LP; Bukauskas, FF; BENNETT, MVL; Sáez JC Article ISI BRAIN RESEARCH REVIEWS (2004)
The formation of skeletal muscle myotubes requires functional membrane receptors activated by extracellular ATP Araya, R; Riquelme, MA; Brandan, E.; Sáez JC Article ISI BRAIN RESEARCH REVIEWS (2004)
Connexin43 is expressed in mouse fetal ovary Perez-Armendariz, EM; Sáez JC; Bravo-Moreno, JF; Lopez-Olmos, V; Enders, GC; Villalpando, I Article ISI SCOPUS ANATOMICAL RECORD (2003)
Functioning of Cx43 hemichannels demonstrated by single channel properties Contreras, JE; Sáez JC; Bukauskas, FF; BENNETT, MVL Article ISI SCOPUS CELL COMMUNICATION AND ADHESION (2003)
Gating and regulation of connexin 43 (Cx43) hemichannels Contreras J.E.; Sáez, J.C.; Bukauskas F.F.; Bennett, M. V. L. Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Presence and importance of connexin43 during myogenesis Araya, R; Eckardt, D; Riquelme, MA; Willecke K.; Sáez JC Article ISI SCOPUS CELL COMMUNICATION AND ADHESION (2003)
TNF-? plus IFN-? induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses Eugenin E.A.; Branes M.C.; Sáez, J.C.; Berman J.W. Article SCOPUS JOURNAL OF IMMUNOLOGY (2003)
ACTIVATION OF HUMAN POLYMORPHONUCLEAR CELLS INDUCES FORMATION OF FUNCTIONAL GAP JUNCTIONS AND EXPRESSION OF CONNEXINS Branes, Maria; Contreras, Jorge; Saez, Juan Article Medical Science Monitor (2002)
Identification of second messengers that induce expression of functional gap junctions in microglia cultured from newborn rats Martínez AD; Eugenin, EA; Branes, MC; BENNETT, MVL; Sáez JC Article ISI SCOPUS BRAIN RESEARCH (2002)
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture Contreras, JE; Sanchez HA; Eugenin, EA; Speidel, D; Theis, M; Willecke K.; Bukauskas, FF; BENNETT, MVL; Sáez JC Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Regulation of hepatic connexins in cholestasis: possible involvement of Kupffer cells and inflammatory mediators González HE; Eugenin, EA; Garces, G; Solís N.; Pizarro M.; Accatino L.; Sáez JC Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)
Expression of connexin43 in mouse Leydig, Sertoli, and germinal cells at different stages of postnatal development Bravo-Moreno, JF; Diaz-Sanchez, V; Montoya-Flores, JG; Lamoyi, E; Sáez JC; Perez-Armendariz, EM Article ISI SCOPUS ANATOMICAL RECORD (2001)
Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha Eugenin, EA; Eckardt, D; Theis, M; Willecke K.; BENNETT, MVL; Sáez JC Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Gap junctions in cells of the immune system: structure, regulation and possible functional roles Sáez JC; Branes, MC; Corvalan, LA; Eugenin, EA; GONZALEZ, H; Martínez AD; Palisson F. Article ISI SCOPUS BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2000)
Gap junctions in the chicken pineal gland Berthoud VM.; Hall, DH; Strahsburger, E; Beyer, EC; Sáez JC Article ISI SCOPUS BRAIN RESEARCH (2000)
Regulation of astrocyte gap junctions by hypoxia-reoxygenation Martínez AD; Sáez JC Article ISI BRAIN RESEARCH REVIEWS (2000)
Arachidonic acid-induced dye uncoupling in rat cortical astrocytes is mediated by arachidonic acid byproducts Martinez A.D.; Sáez, J.C. Article Brain research (1999)
Cells of the carotid body express connexin43 which is up-regulated by cAMP Abudara V, Garcés G, Sáez JC Article ISI (1999)
Chapter 25: Gap Junctions in Inflammatory Responses: Connexins, Regulation and Possible Functional Roles Sáez, J.C.; Araya, R; Branes M.C.; Contreras J.E.; Eugenin E.A.; Martinez A.D.; Palisson F.; Concha M.; Sepúlveda, M.A. Article Current Topics in Membranes and Transport (1999)
The ependymocytes of the bovine subcommissural organ are functionally coupled through gap junctions González C.A.; Schobitz, K; Rodríguez E.M.; Garces, G; Sáez, J.C. Article NEUROSCIENCE LETTERS (1999)
Gap junctional communication coordinates vasopressin-induced glycogenolysis in rat hepatocytes Eugenin E.A.; GONZALEZ, H; Saez C G; Sáez, J.C. Article AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (1998)
Identification of gap junctions in the oviduct and regulation of connexins during development and by sexual hormones Hermoso, M; Sáez, J.C.; Villalón M. Article EUROPEAN JOURNAL OF CELL BIOLOGY (1997)
Phosphorylation of connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions Sáez, J.C.; Spray D.C.; Hertzberg E.L.; Fishman G.I.; Nairn A.C.; Czernik A.J. Article JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (1997)
REGULATION OF GAP-JUNCTIONS BY PROTEIN PHOSPHORYLATION Branes, Maria; Gonzalez, Humberto; Martínez A; Saez, Juan Article BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (1997)
Regulation of glycogen content in rat pineal gland by norepinephrine Eugenin E.A.; Saez C G; Garces, G; Sáez, J.C. Article Brain research (1997)
C-erbB2/neu transfection induces gap junctional communication incompetence in glial cells Hofer A.; Dermietzel R.; Sáez, J.C.; Chang C.C.; Trosko J.E.; Spray D.C. Article JOURNAL OF NEUROSCIENCE (1996)
Regulated assembly of connexin33 and connexin43 into rat Sertoli cell gap junctions Tan I.P.; Risley M.S.; Roy, C; Sáez, J.C.; Saez C G; Paul D.L. Article BIOLOGY OF REPRODUCTION (1996)
Biological mechanisms involved in the spread of traumatic brain damage. Rovegno M, Soto PA, Sáez JC, von Bernhardi R. Article Med. Intensiva (0)
Sepsis-Induced Channelopathy in Skeletal Muscles is Associated with Expression of Non-Selective Channels. Balboa E, Saavedra F; Cea LA, Vargas AA; Ramírez V, Escamilla R; Sáez JC, Regueira T. Article SHOCK (0)


HIV infection of astrocytes increases release of Dickkopf-1 protein by a gap junction and hemichannel dependent mechanism Orellana J.; Saez, J; Berman, J; Eugenin, E Abstract JOURNAL OF NEUROVIROLOGY (2012)
Specific ablation of connexin 43 delays skeletal muscle regeneration in vivo Araya, R; Eckardt, D; Maxeiner, S; Kruger, O; Theis, M; Willecke K.; Saez, J Abstract MOLECULAR BIOLOGY OF THE CELL (2002)


Connexin and Pannexin Based Channels in the Nervous System: Gap Junctions and More Sáez, J.C.; Nicholson B. BookWhole SCOPUS From Molecules to Networks: An Introduction to Cellular and Molecular Neuroscience: Third Edition (2014)


Brain Research Reviews: Preface Sáez, J.C.; Bennett, M. V. L. ConferencePaper BRAIN RESEARCH REVIEWS (2004)


We've had important advances in the connexin/pannexin field, yet there is still much to do Johnson RG, Sáez JC. EditorialMaterial ISI SCOPUS Neuropharmacology (2013)
Astrocytes as connexin-dependent signaling cells for local blood flow regulation Saz, JC EditorialMaterial ISI AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)


UNIONES EN HENDIDURA Y SU PAPEL FUNCIONAL EN EL TRACTO REPRODUCTOR FEMENINO Branes, Maria; Saez, Alejandra; Villalon, Manuel; Saez, Juan Metodologia REVISTA CHILENA DE OBSTETRICIA Y GINECOLOGIA (2004)


DIVERSE CELL TYPES PRESENT PANNEXIN1-BASED GAP JUNCTION CHANNELS WITH DISTINCT REGULATORY, FUNCTIONAL AND PHARMACOLOGICAL PROPERTIES SAEZ, JUAN CARLOS; Sáez, Juan C. Proyecto (2019)
Centro Interdiciplianrio de Neurociencias de Valparaiso Ministerio de Economía, Instituto Milenio de Neurociencias de la Universidad de Valparaiso (P09-022-F) Proyecto 2016-2021 Inv. Principal
UNCOVERING THE ROLE OF HEMICHANNELS IN GLIAL AND NEURONAL DYSFUNCTION INDUCED BY ALPHA-SYNUCLEIN FONDECYT (1160710) Proyecto 2016-2020 Coinvestigador(a)
Neuronal derived factor(s) and mechanim(s) that repress the expression of non-selective ion channels in normal adult skeletal muscles FONDECYT (1150291) Proyecto 2015-2018 Inv. Responsable
RELEVANCIA DEL ESTRÉS OXIDATIVO, LA DISFUNCIÓN MITOCONDRIAL Y LA EXPRESIÓN DE CONEXINAS EN LA INDUCCIÓN DE ATROFIA MUSCULAR POR DEXAMETASONA FONDECYT (3160594) Proyecto 2015-2018 Inv. Patrocinante
CONNEXIN HEMICHANNELS AS MEDIATORS OF SARCOLEMMAL AND MITOCHONDRIAL DYSFUNCTION IN RESPIRATORY AND PERIPHERAL MUSCLE IN THE PATHOGENESIS OF SEPSIS ASSOCIATED-INTENSIVE CARE UNIT ACQUIRED WEAKNESS (ICUAW) FONDECYT (1141092) Proyecto 2014-2018 Coinvestigador(a)
"INVOLVEMENT OF HEMICHANNELS IN GLIA PRE-ACTIVATION BY AUDITORY STRESS TO INFLAMMATION PROMOTED BY POLY (I=>C) AND CONSEQUENCES ON NEURONAL ARBORIZATION AND SURVIVAL" FONDECYT (3130632) Proyecto 2012-2015 Inv. Patrocinante
REGULACION DEL TRANSPORTE DE GLUCOSA, A TRAVES DE SUS TRANSPORTADORES ESPECIFICOS Y HEMICANALES, POR ACIDOS GRASOS ESENCIALES EN INTESTINO DELGADO FONDECYT (3130662) Proyecto 2012-2015 Inv. Patrocinante
Centro Interdiciplianrio de Neurociencias de Valparaiso Ministerio de Economía, Instituto Milenio de Neurociencias de la Universidad de Valparaiso (P09-022-F) Proyecto 2011-2016 Coinvestigador(a)
INVOLVEMENT OF TACE/ADAM17 AND PANNEXIN HEMICHANNELS IN XENOESTROGENS INDUCED APOPTOSIS IN MAMMALIAN SPERMATOGENESIS FONDECYT (1110778) Proyecto 2011-2015 Coinvestigador(a)
REGULATION OF CONNEXIN43 HEMICHANNELS PROPERTIES BY PKC, PKA AND MAP KINASES. FONDECYT (3120006) Proyecto 2011-2013 Inv. Patrocinante
ROLE AND REGULATION OF HEMICHANNELS IN FUNCTIONAL RESPONSES OF INACTIVE, ACTIVE AND ACUTELY CACHEXIC ADULT SKELETAL MUSCLES. FONDECYT (1111033) Proyecto 2011-2015 Inv. Responsable
Role nad regulation of hemichannels in functional responses of inactive, active and acutly cachexic adult skeletal muscle FONDAP (1111033) Proyecto 2011-2015 Inv. Principal
COORDINATION OF MICROVASCULAR FUNCTION BY LONG DISTANCE ENDOTHELIAL CELL SIGNALING BASED ON CONNEXIN-MEDIATED COMMUNICATION AND VOLTAGE-DEPENDENT VASODILATOR MECHANISMS FONDECYT (1100850) Proyecto 2010-2014 Coinvestigador(a)
PATHOGENIC MECHANISM OF CONNEXIN26 MUTATIONS INVOLVED IN SYNDROMIC AND NON-SYNDROMIC DEAFNESS FONDECYT (1090573) Proyecto 2009-2012 Coinvestigador(a)
PAPEL Y REGULACION DE LOS CANALES FORMADOS POR CONEXINA43 ASTROGLIAL EN LA DISFUNCION Y MUERTE CELULAR EN TEJIDO CEREBRAL IN VITRO INDUCIDA POR ISQUEMIA-REPERFUSION EN ALTA GLUCOSA. FONDECYT (1070591) Proyecto 2007-2011 Inv. Responsable
ESTUDIO DEL PAPEL REGULADOR DE LAS CONEXINAS SOBRE EL PROCESO DE NEUROGENESIS Y GLIOGENESIS IN VITRO FONDECYT (1050857) Proyecto 2005-2009 Coinvestigador(a)
IDENTIFICACION Y REGULACION DE VIAS DE SENALIZACION INTERCELULAR EN EL EPITELIO DEL OVIDUCTO QUE CONTROLAN EL TRANSPORTE MUCOCILIAR EN CONDICIONES FISIOLOGICAS Y FISIPATOLOGICAS. FONDECYT (1040804) Proyecto 2004-2008 Coinvestigador(a)
CARACTERIZACION DE MECANISMOS MODULADORES DEL ESTADO FUNCIONAL DE HEMICANALES DE LAS UNIONES EN HENDIDURA EN CELULAS DEL SISTEMA NERVIOSO CENTRAL. FONDECYT (1030945) Proyecto 2003-2007 Inv. Responsable
IMPORTANCIA Y REGULACION DE MECANISMOS DE SENALIZACION INTERCELULAR EN LA RESPUESTA INFLAMATORIA FONDECYT (8990008) Proyecto 1999-2003 Inv. Principal
REGULACION Y FUNCION DE LAS UNIONES EN HENDIDURA EN MODELOS DE INFLAMACION "IN VITRO" FONDECYT (1960559) Proyecto 1996-1999 Inv. Responsable
MECANISMOS DE COORDINACION Y CONTROL DE LA ACTIVIDAD CILIAR EN EL EPITELIO DEL OVIDUCTO. FONDECYT (1940691) Proyecto 1994-1997 Coinvestigador(a)
REGULACION DE LAS UNIONES COMUNICANTES DEL ACINO HEPATICO Y SU POSIBLE FUNCION EN LA RESPUESTA GLUCOGENICA DEL HIGADO FONDECYT (3930011) Proyecto 1993-1996 Inv. Patrocinante
REGULACION Y FUNCION DE LAS UNIONES COMUNICANTES DE LA GLANDULA PINEAL FONDECYT (1930690) Proyecto 1993-1996 Inv. Responsable
SUPEROXIDOS Y PATOGENIA DEL SINDROME DE SHOCK. FONDECYT (1851083) Proyecto 1985-1986 Coinvestigador(a)


Connexins and pannexins in Alzheimer's disease Giaume, C; Saez, JC; Song, WH; Leybaert, L; Naus, CC Review ISI NEUROSCIENCE LETTERS (2019)
Direct Intercellular Communications and Cancer: A Snapshot of the Biological Roles of Connexins in Prostate Cancer Asencio-BarrÃa C.; Defamie N.; SÃ¡ez J.C.; Mesnil M.; Godoy, A. S. Review ISI SCOPUS CANCERS (2019)
Innexins: Expression, Regulation, and Functions Guiza, J; Barria, I; Saez, JC; Vega, JL Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2018)
Role of astrocyte connexin hemichannels in cortical spreading depression Rovegno, M; Saez, JC Review ISI BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)
Connexin-Dependent Neuroglial Networking as a New Therapeutic Target Charvériat M.; Naus C.C.; Leybaert L.; Sáez J.C.; Giaume C. Review ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2017)
Connexins and Pannexins in Bone and Skeletal Muscle Plotkin L.I.; Davis H.M.; Cisterna B.A.; Sáez J.C. Review ISI SCOPUS CURRENT OSTEOPOROSIS REPORTS (2017)
Regulation of pannexin and connexin channels and their functional role in skeletal muscles Sáez JC; Cisterna, BA; Vargas A.; Cardozo, CP Review ISI SCOPUS CELLULAR AND MOLECULAR LIFE SCIENCES (2015)
Hunting for connexin hemichannels Sáez JC, Leybaert L. Review ISI SCOPUS FEBS LETTERS (2014)
Neuronal involvement in muscular atrophy Cisterna, BA; Cardozo C.; Sáez JC Review ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Regulation of Hemichannels and Gap Junction Channels by Cytokines in Antigen-Presenting Cells Sáez PJ; Shoji, KF; Aguirre A.; Sáez JC Review ISI SCOPUS MEDIATORS OF INFLAMMATION (2014)
Connexin and pannexin hernichannels in brain glial cells: properties, pharmacology, and roles Giaume C.; Leybaert, L; Naus, CC; Sáez JC Review ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2013)
Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation Aguirre A, Maturana CJ, Harcha PA, Sáez JC. Review ISI SCOPUS Mediators of Inflammation (2013)
Role of Gap Junctions and Hemichannels in Parasitic Infections Vega, JL; Subiabre, M; Figueroa F.; Schalper, KA; Osorio, L; Gonzalez, J; Sáez JC Review ISI SCOPUS BioMed Research International (2013)
Biological mechanisms involved in the spread of traumatic brain damage Rovegno M.; Soto P.A.; Sáez, J.C.; von Bernhardi R. Review ISI SCOPUS Medicina Intensiva (2012)
Connexin and pannexin hemichannels in inflammatory responses of glia and neurons Bennett, M. V. L.; Garre J.M.; Orellana J.A.; Bukauskas F.F.; Nedergaard M.; Sáez, J.C. Review ISI SCOPUS Brain Research (2012)
Connexin- and Pannexin-Based Channels in Normal Skeletal Muscles and Their Possible Role in Muscle Atrophy Cea L.A.; Riquelme, M. A.; Cisterna B.A.; Puebla, C; Vega, J. L.; Rovegno M.; Sáez, J.C. Review ISI SCOPUS Journal of Membrane Biology (2012)
Glial connexin expression and function in the context of Alzheimer's disease Koulakoff A.; Mei X.; Orellana J.A.; Sáez, J.C.; Giaume C. Review ISI SCOPUS Biochimica et Biophysica Acta - Biomembranes (2012)
Modulation of gap junction channels and hemichannels by growth factors Schalper K.A.; Riquelme, M. A.; Branes M.C.; Martinez A.D.; Vega, J. L.; Berthoud V.M.; Bennett, M. V. L.; Sáez, J.C. Review ISI SCOPUS Molecular BioSystems (2012)
The Role of Gap Junction Channels During Physiologic and Pathologic Conditions of the Human Central Nervous System Eugenin, EA; Basilio D.; Sáez JC; Orellana, JA; Raine, CS; Bukauskas, F; BENNETT, MVL; Berman, JW Review ISI SCOPUS Journal of Neuroimmune Pharmacology (2012)
Cell membrane permeabilization via connexin hemichannels in living and dying cells Sáez JC; Schalper, KA; Retamal, MA.; Orellana, JA; Shoji, KF; BENNETT, MVL Review ISI SCOPUS Experimental Cell Research (2010)
Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration Orellana, JA; Sáez PJ; Shoji, KF; Schalper, KA; Palacios-Prado, N; Velarde, V; Giaume C.; BENNETT, MVL; Sáez JC Review ISI ANTIOXIDANTS & REDOX SIGNALING (2009)
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion Retamal, MA.; Schalper, KA; Shoji, KF; Orellana, JA; BENNETT, MVL; Sáez JC Review ISI JOURNAL OF MEMBRANE BIOLOGY (2007)
Connexin-based gap junction hemichannels: Gating mechanisms Sáez JC; Retamal, MA.; Basilio D.; Bukauskas, FF; BENNETT, MVL Review ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2005)
GAP JUNCTION HEMICHANNELS IN ASTROCYTES OF THE CNS Saez, Juan; Contreras, Jorge; Bukauskas, Feliksas; Retamal, Mauricio; Bennett, Michael Review ACTA PHYSIOLOGICA SCANDINAVICA (2003)
New roles for astrocytes: Gap junction hemichannels have something to communicate BENNETT, MVL; Contreras, JE; Bukauskas, FF; Sáez JC Review ISI TRENDS IN NEUROSCIENCES (2003)

223

Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Mauricio Retamal

Associate Professor

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

HELMUTH SANCHEZ

INVESTIGADOR ADJUNTO

Laboratorio de Conexinas y Panexinas

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAISO

VALPARAISO, Chile

Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

Vania Figueroa

Directora InES Género y CTGénero, Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

ROSALBA ESCAMILLA

Investigador asociado

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Cristian Vilos

Académico Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

Iván Barría

Investigador Post doctoral

Centro Interdisciplinario de Neurociencia de Valparaíso

Valparaíso, Chile

Aníbal Vargas

Investigador postdoctoral

Universidad Mayor

Santiago, Chile

Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

Carolina Flores

Investigador Postdoctoral

Neurociencias

Universidad de Valparaíso

Valparaíso, Chile

Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Ricardo Ceriani

Profesor adjunto

Farmacia

Universidad Valparaíso

Valparaíso, Chile

YORLEY DUARTE

profesor Asistente

Universidad Andrés Bello

Santiago, Chile

Paloma Harcha

Investigadora Postdoctoral

Universidad de Valparaíso

Valparaíso, Chile

Claudia Garcia

Candidata a doctora

Ciencias

Universidad de Valparaíso

Valparaíso, Chile

Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

Susana Contreras

Assistant Professor

Nutrition and Dietetics

Universidad San Sebastián

Santiago, Chile

Alex Vielma

Postdoctoral researcher

Centro Interdisciplinario de Neurociencias de Valparaíso

Valparaiso, Chile

PAOLA SOTO

Investigadora Laboratorio Fisiología Integrativa y Molecular

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

Rodrigo Acuña

Profesor Asistente Investigador

Medicina

Universidad del Desarrollo

Santiago, Chile

Mariana Casas

Assistant Professor

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Daniela Salas

ELISA BALBOA

Académico Investigador

Facultad de Medicina

Universidad Finis Terrae

SANTIAGO, Chile

Rodrigo Moraga

Postdoctoral researcher

Nuklear Medizin

Medizinische Hochschule Hannover

Hannover, Alemania

Ana Cárdenas

Professor

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Roberto Elizondo

Profesor Asistente

Departamento de Biología Celular

Universidad de Concepción

CONCEPCION, Chile

Loreto Véliz

Profesor Asistente Adjunto

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Claudia Lucero

Asistente Investigación-Docente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

David Rovegno

PROFESOR ASISTENTE ADJUNTO

Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

PEDRO ZAMORANO

Profesor Asociado

Depto Biomédico

Universidad de Antofagasta

Antofagasta, Chile

Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

Jaime De Calisto

Director Docente

Escuela de Biotecnología

Universidad Mayor

Santiago, Chile

Marlene Arismendi

INVESTIGADOR JEFE

INVESTIGACION Y DESARROLLO

NANOTEC S.A

SANTIAGO, Chile

Gonzalo Gomez

Profesor Asistente

Instituto de Ciencias de la Saluda

Universidad Autónoma de Chile

Santiago, Chile

Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

alejandro bernardin

PhD (c)

Fundación Ciencia y Vida

Santiago, Chile

Mario Rosemblatt

Executive Director

Fundacion Ciencia & Vida

Santiago, Chile

Jorge Bevilacqua

Profesor Titular

Neurología y Neurocirugía

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, ESCUELA DE MEDICINA

Santiago, Chile

DINKA MANDAKOVIC

Assistant Professor

GEMA Center

Universidad Mayor

Santiago, Chile

Alberto Martin

Associate professor

Centro Ciencia & Vida

Universidad San Sebastián

Santiago, Chile

Sonja Buvinic

Associate Professor

Institute for Research in Dental Sciences

Universidad de Chile

Santiago, Chile

ANDRES KLEIN

Assistant Professor/Director (Head) Center for Genetics and Genomics; Director, PhD Program in Sciences and Innovation in Medicine

Centro de Genética y Genómica

Universidad del Desarrollo-Clínica Alemana

SANTIAGO, Chile

Trinidad Montero

postdoctorate

Medicine

Pontificia Universidad Católica de Chile

Santiago, Chile

Oliver Schmachtenberg

Investigador titular

Instituto de Biología

Universidad de Valparaíso, CINV

Valparaíso, Chile

Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

Alejandra Vielma

Post-doctorado

Ciencias Biológicas, Ciencias Fisiológicas

Pontificia Universidad Católica de Chile

Santiago, Chile

ISAAC GARCÍA

Profesor Adjunto

Instituto de Neurociencias

Universidad de Valparaiso

Valparaiso, Chile

Raul Araya

Docente Investigador

Facultad de Ingenieria y Tecnologia

Universidad San Sebastián

Santiago, Chile

Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

Fernando Delgado

Associate Professor

Division of Medicine

Universidad Catolica del Maule

Talca, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Pablo Olivero

Profesor Adjunto

Patologia y Fisiologia

Universidad de Valparaiso

Viña del Mar, Chile

Luis Leon

Head of Bioinformatics and Computational Biology

Technology

PhageLab

Santiago, Chile

Julio Alcayaga

Profesor Titular

Biología

UNIVERSIDAD DE CHILE, FAC. CIENCIAS, DEPTO. BIOLOGÍA

Santiago, Chile

María García

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Mario Subiabre

Ricardo Fernández

Associate Professor

Salud

Universidad de Los Lagos

Osorno, Chile

Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

Adrian Palacios

Profesor

Instituto de Neurosciencia

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

DOMINGO BONANSCO

Profesor Titular

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

Daniel Escobar

PROFESIONAL

SALUD AMBIENTAL

INSTITUTO DE SALUD PÚBLICA DE CHILE

SANTIAGO, Chile

Hernan Gonzalez Diaz

Associate Professor

Cirugía Oncológica

Pontificia Universidad Católica de Chile

Santiago, Chile

Claudia Pareja

Investigadora de Postdoctorado

Departamento de Hematología-Oncología

Pontificia Universidad Católica de Chile

Santiago, Chile

Jorge Gonzalez

Profesor Titular

Departamento de Tecnología Médica

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

Mauricio Henriquez

Profesor asistente

PROGRAMA DE FISIOLOGÍA Y BIOFíSICA

Universidad de Chile / Facultad de Medicina

Santiago, Chile

Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

Carlos Farkas

PostDoctoral Fellow

CancerCare Manitoba

University of Manitoba

Winnipeg, Canada

César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

Sebastián Gutiérrez

Investigador postdoctoral

Fundación Ciencia & Vida

Santiago, Chile

Patricio Órdenes

Docente

Facultad de Ciencias de la Salud

Universidad San Sebastián

Concepción, Chile

Alexies Dagnino

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Antonia Recabal

Docente

Universidad Católica de la Santisima Concepción

Concepción, Chile

María José Barahona

Investigadora posdoctoral

Biología Celular

Universidad de Concepción

Concepción, Chile

Melissa Alegría

Académico Asociado

Facultad de Ingeniería y Negocios

Universidad de Las Américas

Santiago, Chile

Walter Vásquez

Estudiante de doctorado

Centro interdisciplinario de neurociencias de Valparaíso

Universidad de Valparaíso

Valparaíso, Chile

EDUARDO CHAMORRO

Director CENTRO DE QUIMICA TEÓRICA & COMPUTACIONAL (CQT&C)

Departamento de Ciencias Químicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

María Pertusa

Profesor Asociado

Biology

UNIVERSIDAD DE SANTIAGO DE CHILE. FACULTAD QUÍMICA Y BIOLOGÍA

Santiago, Chile

Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Margarita Pizarro

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Erwin Strahsburger

Instructor Professor

Universidad Arturo Prat

Iquique, Chile

Juan Carlos Saez Carreño

Líneas de Investigación

Educación

Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1979

Neurociencias, ALBERT EINSTEIN COLLEGE OF MEDICINE. Estados Unidos, 1986

Experiencia Académica

Instructor Full Time

Assistant Professor Full Time

Assistant Professor Full Time

Associate Professor Full Time

Full Professor Full Time

Full Professor Full Time

Experiencia Profesional

INstructor Full Time

Assistant Professor Full Time

Assistant Professor Full Time

Associate Professor Full Time

Professor Full Time

Professor Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Scopus

Member of the National Academy of Science USA

Member of the Latin American Academy of Science

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