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Steffen Hartel Grundler

Full Professor

University of Chile

Santiago, Chile

Scientific Imaging and Microscopy; Computational Medicine; Cellular Biology; Image Processing; Membrane Biophysics, Medical Informatics

Diploma in Physics, UNIVERSITAT BREMEN. Alemania, 1996
Dr rer nat Physics, UNIVERSITAT BREMEN. Alemania, 2000

Assistant Professor Full Time

UNIVERSIDAD DE CHILE

Medicine

Santiago, Chile

Enero 2006 - Enero 2011
Associated Professor Full Time

UNIVERSIDAD DE CHILE

Medicine

Santiago, Chile

Enero 2012 - Enero 2017
Full Professor Full Time

UNIVERSIDAD DE CHILE

Medicine

Santiago, Chile

Enero 2017 - A la fecha

Postdoc Full Time

Bremen Universitat

Bremen, Alemania

Enero 2000 - Enero 2000
Postdoc / Automatic Video-Analysis And Textual Annotation (Avanta) Full Time

Center For Computing Technologies (Tzi) / Dfg- Schwerpunkt-Program

Bremen, Alemania

Enero 2001 - Enero 2001
Postdoc / Structure, Dynamics And Kinetics In Biomembranes And Necrobiological Processes Focussed Full Time

Universidad de Córdoba / Alexander Von Humboldt Foundation

Córdoba, Argentina

Enero 2001 - Enero 2003
Postdoc / Mechanisms Of Apoptotic And Necrotic Cell Death: Time Resolved Multi-Parameter Analysis Full Time

Centro De Estudios Cientificos (CECS) and Universidad Austral de Chile

Valdivia, Chile

Enero 2003 - Enero 2006
Subdirector of Research, Instituto de Ciencias Biomedicas, Facultad de Medicina Other

Universidad de Chile

Santiago, Chile

Enero 2015 - A la fecha
Director of Center of Medical Informatics and Telemedicine, CIMT, Faculty of Medicine Full Time

Universidad de Chile

Santiago, Chile

Enero 2016 - A la fecha
Director, National Center for Health Information Systems, CENS, CTTS-66390 Part Time

CORFO

Santiago, Chile

Enero 2017 - A la fecha

Post-doctoral Sponsor (4)
===============
1.- 2013-2016. Victor Castañeda, post-doctoral FONDECYT 3140444 "Particle filter based tracking and segmentation pipeline for the analysis of cell shape in large biomedical imaging data".
2.- 2013-2016. Mauricio Cerda, post-doctoral FONDECYT 3140447 "Structural and dynamical priors for the characterization of tubular networks in cell biology".
3.- 2012-2015, German Reig, post-doctoral FONDECYT 3130598 "Papel de la adhesión diferencial y la inhibición por contacto de locomoción celular como motores de la expansión tisular en la epibolia de peces teleósteos".
4.- 2010-2013. Omar Ramírez, post-doctoral FONDECYT 3110157 "Structure and Dynamics of the Endoplasmic Reticulum: Molecular Mechanisms at the Interface of Form and Function".

Phd Tutor / Co-tutor (9)
===============
1.- 2013, PhD co-tutor, Alex Cordova, F-Med, U-Chile
2.- 2013, PhD co-tutor, Jorge Toledo, F-Med, U-Chile
3.- 2013, PhD co-tutor, Sandra de la Fuente, Public Health School, F-Med, U-Chile.
4.- 2012, PhD co-tutor, Violeta Chang, Characterization of Human Sperm Components for an Accurate Morphological Analysis. Departamento de Ciencias de la Computación. In progress.
5.- 2012, PhD co-tutor, Raquel Pezoa , A segmentation method for images with subjective contours in the field of digital pathology. Universidad Técnica Federico Santa María. In progress.
6.- 2010, PhD co-tutor, Rodrigo Rojas, Image segmentation constrained to topological invariants for digital pathology and medical imaging. Universidad Técnica Federico Santa Mária. In progress.
7.- 2009-2010, PhD co-tutor, Pablo Aguilar, Departamento de Ciencias de la Computación, U-Chile.
8.- 2009, PhD co-tutor, Jorge Jara, "Superficies Activas y Conceptos de Vecindades Tridimensionales para la Cuantificación y Parametrización de Fenómenos de Compactación en Estructuras Biológicas", Departamento de Ciencias de la Computación, Universidad de Chile. In process.
9.- 2009-2011, PhD co-tutor, José del Piano, Departamento de Ingeniería Electrica, U-Chile.

Summer Schools & short courses (>10)
===============
1.- 2014, F-Med, U-Chile, Summer School Optics, Forces & Development, organizer and lectures.
2.- 2014, F-Med, U-Chile, first BioMed-HPC collaboration network meeting.
3.- 2013, F-Med, U-Chile and DAAD, "Diplomado en Informatica Medica, Sistemas de Información en Salud: Requisitos para un Diseño e Implementación Exitoso"
4.- 2013, Instituto Clemente Estable, Montevideo, Uruguay, The Microbial World through different eyes.
5.- 2013, F-Med, U-Chile and DAAD, Summer School Computational Bio-Medicine, organizer and lectures.
6.- 2013, F-Med, U-Chile, Summer School Optics, Forces & Development, organizer and lectures.
7.- 2011, F-Med, U-Chile and DAAD, "Diplomado en Informatica Medica, Sistemas de Información en Salud: Requisitos para un Diseño e Implementación Exitoso".
8.- 2010, Instituto Clemente Estable, Montevideo, Uruguay, "MICROSCOPÍA DE FLUORESCENCIA."
9.- 2005, Universidad de la República, Montevideo, Uruguay, "DECONVOLUCION Y RECONSTRUCCIÓN DE ESTRUCTURAS 10.- 2003, DIMENSIONALES EN LA MICROSCOPIA CONFOCAL."

See a detailed list of other short lectures (from 2006-2014) at http://www.scian.cl/portal/globals.php?COD_SECCION=2960

Research units (5)
===============
1.- 2012, responsible of Alex Cordova research units course, Ciencias Biomédicas Phd Program, F-Med, U-Chile.
2.- 2009, with Dr. Miguel Concha, responsable of Germán Reig research units course, Ciencias Biomédicas Phd Program, F-Med, U-Chile.
3.- 2009, with Dr. Miguel Concha, responsable of Eduardo Pulgar research units course, Ciencias Biomédicas Phd Program, F-Med, U-Chile. "Campos de especialización procesos migratorios y las transformaciones de la organogénesis células precursoras dorsal".
4.- 2008, with Dr. Miguel Concha, responsable of Germán Reig research units course, Ciencias Biomédicas Phd Program, F-Med, U-Chile. "Campos de especialización son la biología del pez cebra, de desarrollo, la morfogénesis y la proyección de imagen confocal de 4D."
5.- 2007, with Dr. Miguel Concha, responsable of Karina Palma research units course Biological Sciences Master program, F-Med, U-Chile. "Análisis Morfo -Topológico de la Migración Asimétrica del Órgano Parapineal en el Desarrollo Embrionario de Pez Cebra (Danio rerio)".

Master level (5)
===============
1.- 2014. Images and bio-signals processing I & II. Responsible Professor. Medical Informatics Program, F-Med, U-Chile.
2.- 2014. Bibliographic seminar course. Responsible Professor. Medical Informatics Program, F-Med, U-Chile.
3.- 2012. Images and bio-signals processing I & II. Responsible Professor. Medical Informatics Program, F-Med, U-Chile.
4.- 2012. Bibliographic seminar course. Responsible Professor. Medical Informatics Program, F-Med, U-Chile.
5.- 2012-2014. Coordinator of the Medical Informatics Program, F-Med, U-Chile.

Undergraduate (10)
===============
1.- 2014, responsible of Computer Engineer thesis, Iván Rojas. Department of Computer Science (DCC), FCFM, U-Chile. "Optimización y paralización de un algoritmo de generación de skeletons".
2.- 2012, responsible of Computer Engineer thesis, Liliana Alcayaga Gallardo. DCC, FCFM, U-Chile. "Esqueletonización de estructuras biológicas tridimensionales."
3.- 2008, responsible of Mathematical Engineer thesis, Luis Felipe Olmos Marchant, Department of Mathematics, FCFM, U-Chile. ’Conceptos de Vecindades Tridimensionales para la Cuantificación y Parametrización de Fenómenos de Compactación en Estructuras Biológicas.’
4.- 2006, responsible of Computer Engineer thesis, Jorge Francisco Jara Wilde, Escuela de Ingeniería Civil en Informática (EICI), Universidad Austral de Chile (U-Austral). "Contornos activos y su aplicación para la segmentación y parametrización tridimensional de estructuras biológicas."
5.- 2005, responsible of Computer Engineer thesis, Etiene Valentino Verdugo Ruiz, EICI, U-Austral. "Reconstrucción, visualización y parametrización tridimensional de estructuras biológicas a través de imágenes confocales de fluorescencia."
6.- 2003, responsible of Computer Engineer thesis María Luisa Oyarzo Vergara, Physics Department (PD) and EICI, U-Austral "Segmentación y análisis automatizado de objetos en movimiento aplicado al estudio microscópico de sistemas biológicos en tiempo real."
7.- 2001, collaborator of Computer Engineer thesis, Pamela Barria PD & EICI, U-Austral. "Plataforma de Identificación, Clasificación y Análisis de Imágenes, obtenidas a partir de muestras Celulares."
8.- 2001, collaborator of Computer Engineer thesis, Victor Espinoza Romero, PD & EICI, U-Austral. "Plataforma de Identificación, Clasificación y Análisis de Imágenes, obtenidas a partir de muestras Celulares."
9.- 2001, collaborator of Computer Engineer thesis Rodrigo Rojas Moraleda, PD & EICI, U-Austral. "Plataforma de Identificación, Clasificación y Análisis de Imágenes, obtenidas a partir de muestras Celulares."
10.- 2000, Tutor for the diploma thesis in experimental physics, Mr. Marcus Haas, University of Bremen: "Charakterisierung der Fluoreszenzeigenschaften des Farbstoffs DiI-CN in Zusammenhang mit der Bestimmung von physikalischen Zuständen in Lipidmembranen".

Academic Excellence in Research Medal

University of Chile

Chile, 2013

Special distinction for academic excellence in research at F-Med, U-Chile.
Iberoamerican award to innovation and entrepreneurship (SEGIB)

Secretaria General Iberoamericana

España, 2012

The Iberoamerican awards for Innovation and entrepreneurship are awarded to projects technology, products and services,
Academic Excellence in Research Medal

University of Chile

Chile, 2012

Medalla a la excelencia académica otorgada por autoridad maxima de la facultad de medicina de la universidad de chile
Innovative Vision award 100K 2011

Banco Santander - Universia

Chile, 2011

seed capital award for technological innovations projects.
Digital Thesis of the Year

UNIVERSIA (www.universia.cl) and Fundación Pais Digital, Chile and Fundación Pais Digital, Chile

Chile, 2007

Supervisor of the Diploma Thesis.
Doctor José Tohá Castella

EXPLORA of the Comisión Nacional de Investigación Científica y Technológica, CONICYT

Chile, 2005

Recognition for outstanding divulgation of science and technology activities.
Feodor Lynen Fellowship

Alexander von Humboldt Foundation

Alemania, 2001

Feodor Lynen Fellowship.
Special award for the Ph.D. thesis

Bruker Daltonik GmbH

Chile, 2000

Special award for the Ph.D. thesis
Bremer Studienpreis for the best Ph.D. thesis in natural sciences of the year

University of Bremen

Chile, 2000

the best Ph.D. thesis in natural sciences of the year
Dissertation passed with Maximum Distinction summa cum laude

University of Chile

Chile, 2000

summa cum laude
Travel & Investigation Grant, DAAD

German Foreign Academic Exchange Agency

Chile, 1997

Travel & Investigation Grant, DAAD.
Bremer Studienfonds e.V, Investigation Fellowship & Travel Fellowship, DAAD

German Foreign Academic Exchange Agency

Chile, 1995

to perform research at the Instituto de Física, Universidad Austral de Chile, Valdivia, Chile
Recognition for its Contribution to Research under the ISI-WOS 2017 Publication, entitled "Extra-Embryonic tissue spreading direct early embryo morphogenesis in killifish"

UNIVERSIDAD DE CHILE

Chile, 2018

Located in the top 6% of its discipline. Published in the journal Nature Communications
Recognition for its Contribution to Research under the Publication ISI-WOS 2017, entitled "Epigenetic editing of th Dlg4 / PSD95 gene improves cognition in aged and Alzheimer's disease mice"

UNIVERSIDAD DE CHILE

Chile, 2018

Located in the top 6% of its discipline. published in the journal Brain.
Recognition for its Contribution to Research under the Publication ISI-WOS 2017, entitled "Directional asymmetry in the volume of the human habenula"

UNIVERSIDAD DE CHILE

Chile, 2018

Located in the top 6% of its discipline. Published in the journal Brain Structure & Function
Recognition for its Contribution to Research under the Publication ISI-WOS 2017, "Extra-embryonic tissue spreading direct early embryo morphogenesis in killifish"

UNIVERSIDAD DE CHILE

Chile, 2018

Located in the top 6% of its discipline. Published in the journal Nature Communications.
Recognition for its Contribution to Research under the award of the Fondecyt-Regular 2018 project, entitled "5D Image Processing and Physical Models for the Quantification of Cell Migration and Multicellular Architecture with 4-Lens Light Sheet Fluorescen

UNIVERSIDAD DE CHILE

Chile, 2018

Evaluation in the top 10% of the Engineering study group 2.
Special recognition for its contribution to the value that university internalization must play in the development of the University of Chile and the country

UNIVERSIDAD DE CHILE

Chile, 2018

Recognition for their work in promoting and specifying internationalization activities.


Variable numbers of calreticulin genes in Trypanosoma cruzi correlate with atypical morphology and protein expression Gonzalez, Andrea; Hartel, Steffen; Mansilla, Jorge; Sanchez-Valdez, Fernando; Ferreira, Arturo Article ISI SCOPUS IMMUNOBIOLOGY (2018)
Epigenetic editing of the PSD95 gene improves cognition in aged and Alzheimer's disease mice Bustos, F; Ampuero, E; Aguilar, R; Jury, N; Varela-Nallar, L; Falahi, F; Toledo, J; Ahumada, J; Lata, J; Cubillos, P; Henríquez, B; Guerra, M; Stehberg, J; Neve, R; Inestrosa, N; Wyneken, U; Fuenzalida, M; Härtel, S; Sena-Esteves, M; Rots, M; Montecino, M; B Van Zundert Article Brain (2017)
Asymmetric morphogenesis of the parapineal organ in the embryonic zebrafish brain Lemus, Carmen Gloria; Palma, Karina; Jara, Jorge; Cramer, Teresa; Härtel, Steffen; Concha, Miguel Article ISI MECHANISMS OF DEVELOPMENT (2017)
Automatic classification of human sperm head morphology Chang, V; Heutte, L; Petitjean, C; Hartel, S; Hitschfeld, N Article ISI SCOPUS COMPUTERS IN BIOLOGY AND MEDICINE (2017)
CDK5 downregulation enhances synaptic plasticity Posada-Duque, R; Ramírez, O; Hartel, S; Inestrosa, N; Bodaleo, F; González-Billault, C; Kirkwood, A; Cardona-Gómez, G Article CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice Bustos, Fernando J; Ampuero, Estibaliz; Jury, Nur; Aguilar, Rodrigo; Falahi, Fahimeh; Toledo, Jorge; Ahumada, Juan; Lata, Jaclyn; Cubillos, Paula; Henríquez, Berta; Guerra, Miguel V; Stehberg, Jimmy; Neve, Rachael L; Inestrosa, Nibaldo C; Wyneken, Ursula; Fuenzalida, Marco; Härtel, Steffen; Sena-Esteves, Miguel; Varela-Nallar, Lorena; Rots, Marianne G; Montecino, Martin; van Zundert, Brigitte Article ISI SCOPUS Brain (2017)
Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish Reig, G; Cerda, M; Sepúlveda, N; Flores, D; Castaneda, V; Tada, M; Hartel, S; Concha, M Article ISI SCOPUS NATURE COMMUNICATIONS (2017)
Gastrulation in an annual killifish: Molecular and cellular events during germ layer formation in Austrolebias Pereiro, L; Loosli, F; Fernandez, J; Hartel, S; Wittbrodt, J; Concha, ML Article ISI SCOPUS DEVELOPMENTAL DYNAMICS (2017)
Gold-standard for computer-assisted morphological sperm analysis Chang, V; Garcia, A; Hitschfeld, N; Hartel, S Article ISI SCOPUS COMPUTERS IN BIOLOGY AND MEDICINE (2017)
Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons Ampuero E.; Jury N.; Härtel S.; Marzolo M.-P.; van Zundert B. Article ISI SCOPUS Journal of cellular physiology (2017)
Light/dark cycles modulate asymmetric parapineal connectivity to the left habenula in zebrafish larvae Palma, Karina; Meynard, Margarita; Cornejo, Valeria; Cerda, Mauricio; Jara, Jorge; Härtel, Steffen; Concha, Miguel Article ISI MECHANISMS OF DEVELOPMENT (2017)
RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid beta Peptide Oligomers SanMartín, Carol D.; Veloso, Pablo; Adasme, Tatiana; Lobos, Pedro; Bruna, Barbara; Galaz, Jose; García, Alejandra; Hartel, Steffen; Hidalgo, Cecilia; Paula-Lima, Andrea C. Article ISI SCOPUS Frontiers in Molecular Neuroscience (2017)
Sleep/wake disorders and the hypocretin/orexin system in a zebrafish model of Parkinson's Disease Izquierdo, Almudena Laliena; Castañeda, Víctor; Härtel, Steffen; Concha, Miguel Article ISI MECHANISMS OF DEVELOPMENT (2017)
A frame-based ANN for classification of hyperspectral images: assessment of mechanical damage in mushrooms Rojas-Moraleda, R; Valous, N; Gowen, A; Esquerre, C; Hartel, S; Salinas, L; O'Donnell, C Article Neural Computing and Applications (2016)
Directional Asymmetry in the Volume of the Human Habenula Ahumada, P; Lemus, C; Diaz, E; Osorio-Reich, M; Hartel, S; Concha, ML Article Brain Structure and Function (2016)
Fimbriae have distinguishable roles in Proteus mirabilis biofilm formation Scavone, Paola; Iribarnegaray, Victoria; Caetano, Ana Laura; Schlapp, Geraldine; Hrtel, Steffen; Zunino, Pablo; Ruzicka, Filip Article ISI SCOPUS Pathogens and Disease (2016)
Leader Cells Define Directionality of Trunk, but Not Cranial, Neural Crest Cell Migration Richardson J.; Gauert A.; Briones Montecinos L.; Fanlo L.; Alhashem Z.M.; Assar, R; Marti E.; Kabla A.; H&#228rtel S.; Linker, C Article ISI SCOPUS Cell Reports (2016)
Segmentation of HER2 protein overexpression in immunohistochemically stained breast cancer images using Support Vector Machines Pezoa, R; Salinas, L; Torres, C; Hartel, S; Maureira-Fredes, C; Arce, P Article Journal of Physics (2016)
An Implementation of Combined Local-Global Optical Flow Jara-Wilde, J; Cerda M.; Delpiano, J; Hartel, S Article ISI IMAGE PROCESSING ON LINE (2015)
Higher blood vessel density in comparison to the lymphatic vessels in oral squamous cell carcinoma Maturana Ramirez A; Espinoza, I; Reyes, M; Aitken JP; Aguayo, F.; Hartel, S; Rojas Alcayaga G. Article ISI international journal of clinical and experimental pathology (2015)
Transactivation activity and nucleocytoplasmic transport of beta-catenin are independently regulated by its C-terminal end Maturana, JL; Niechi, I; Silva, E.; Huerta H.; Cataldo, R; Hartel, S; Barros, LF; Galindo, M; Tapia, JC Article ISI SCOPUS Gene (2015)
Trypanosoma cruzi Calreticulin Topographical Variations in Parasites Infecting Murine Macrophages González A; Valck C; Sánchez G; Hartel, S; Mansilla, J; Ramirez G.; Fernandez, MS; Arias, JL; Galanti N.; Ferreira A. Article ISI SCOPUS American Journal of Tropical Medicine and Hygiene (2015)
Trypanosoma cruzi infectivity assessment in "in vitro" culture systems by automated cell counting Liempi, A; Castillo C.; Cerda M.; Droguett, D; Duaso, J; Barahona, K; Hernandez A.; Diaz-Lujan, C; Fretes R.; Hartel, S; Kemmerling U. Article ISI SCOPUS Acta Trop. (2015)
Bleomycin-induced gamma H2AX foci map preferentially to replicating domains in CHO9 interphase nuclei Liddle P.; Lafon-Hughes L.; Di Tomaso M.V.; Reyes-Abalos A.L.; Jara, J; Cerda M.; Hartel, S; Folle G.A. Article ISI SCOPUS Chromosome Research (2014)
Computational Methods for Analysis of Dynamic Events in Cell Migration Castaneda, V; Cerda M.; Santibanez F.; Jara, J; Pulgar E.; Palma K.; Lemus, CG; Osorio-Reich, M; Concha, ML; Hartel, S Article ISI CURRENT MOLECULAR MEDICINE (2014)
Gold-standard and improved framework for sperm head segmentation Chang V.; Saavedra, JM; Castaneda, V; Sarabia L.; Hitschfeld, N; Hartel, S Article ISI SCOPUS Computer Methods and Programs in Biomedicine (2014)
Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons San Martín, CD; Paula-Lima, AC; García, A; Hartel, S; Núñez, MT; Hidalgo, C Article Frontiers in Molecular Neuroscience (2014)
Spermatozoa from mice deficient in Niemann- Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability Busso, D; Oñate-Alvarado, MJ; Balboa, E; Castro, J; Lizama, C; Morales, G; Vargas, S; Hartel, S; Moreno, RD; Zanlungo, S Article Reproduction Fertility and Development (2014)
Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth Colombo A, Palma K, Armijo L, Mione M, Signore I, Morales C, Guerrero N, Meynard M, Pérez R, Suazo J, Marcelain-Cubillos K, Briones L, Hartel S, Wilson S and M Concha Article Development (2013)
A method for analysis of lipid vesicle domain structure from confocal image data Husen P.; Fidorra, M; Hartel, S; Bagatolli L.A.; Ipsen J.H. Article ISI SCOPUS European Biophysics Journal (2012)
Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the Rear in Metastatic Cancer Cells Urra, H; Torres V.A.; Ortiz R.J.; Lobos L; Díaz M.I.; Díaz N; Hartel, S; Leyton, L; Quest, A.F.G. Article ISI SCOPUS PLoS ONE (2012)
TRP, TRPL and Cacophony Channels Mediate Ca2+ Influx and Exocytosis in Photoreceptors Axons in Drosophila Astorga, G; Hartel, S; Sanhueza M.; Bacigalupo, J Article ISI SCOPUS PLoS ONE (2012)
Association of age with sperm DNA fragmentation Horta, F; Madariaga M.; Garcia, A.; Hartel, S; Smith, R Article ISI REVISTA MEDICA DE CHILE (2011)
Aumento del daño en el ADN espermático en varones mayores de 40 años Horta, Fabrizzio; Madariaga, Marcia; Garcia, Alejandra; Hartel, Steffen; Smith, Rosita Article SCIELO SCOPUS REVISTA MEDICA DE CHILE (2011)
Changes in Rab3D Expression and Distribution in the Acini of Sjogren's Syndrome Patients Are Associated With Loss of Cell Polarity and Secretory Dysfunction Bahamondes, V; Albornoz, A; Aguilera, S; Alliende C; Molina C.; Castro, I; Urzua, U; Quest, AFG; Barrera, MJ; Gonzalez S.; Sánchez, M; Hartel, S; Hermoso, M; Leyton, C; Gonzalez, MJ Article ISI SCOPUS Arthritis and Rheumatism (2011)
Development of 3D architecture of uropathogenic Proteus mirabilis batch culture biofilms-A quantitative confocal microscopy approach Schlapp, G.; Scavone, P.; Zunino, P; Hartel, S Article ISI SCOPUS Journal of Microbiological Methods (2011)
High-Frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-Mediated Ca2+ Release and Generates Hydrogen Peroxide, Which Jointly Stimulate NF-kappa B Activity Riquelme, D.; Alvarez A.; Leal N.; Adasme, T.; Espinoza, I; Valdes, JA; Troncoso N.; Hartel, S; Hidalgo J.; Hidalgo C.; Carrasco, MA Article ISI SCOPUS Antioxidants and Redox Signaling (2011)
Location matters: the endoplasmic reticulum and protein trafficking in dendrites Ramirez, OA; Hartel, S; Couve, A Article ISI SCIELO SCOPUS Biological Research (2011)
Microtubule-associated Protein 1B (MAP1B) Is Required for Dendritic Spine Development and Synaptic Maturation Tortosa E.; Montenegro-Venegas, C; Benoist, M; Hartel, S; Gonzalez-Billault, C; Esteban, JA; Avila J. Article ISI SCOPUS Journal of Biological Chemistry (2011)
Performance of optical flow techniques for motion analysis of fluorescent point signals in confocal microscopy Delpiano, J; Jara, J; Scheer, J; Ramirez, O; Ruiz-del-Solar, J; Härtel, S Article Machine Vision and Applications (2011)
Confined displacement algorithm determines true and random colocalization in fluorescence microscopy Ramirez, O.; Garcia, A.; Rojas, R.; Couve, A; Hartel, S Article ISI SCOPUS Journal of Microscopy (2010)
Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ Oteiza, P; Koppen, M; Krieg M.; Pulgar E.; Farias, C; Melo, C; Preibisch, S; Muller, D; Tada M.; Hartel, S; Heisenberg, CP; Concha, ML Article ISI SCOPUS Development (Cambridge) (2010)
Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by freeze-drying and rotary shadowing for electron microscopy Cárdenas C; Escobar M.; Garcia, A.; Osorio-Reich, M; Hartel, S; Foskett, JK; Franzini-Armstrong, C Article ISI SCOPUS Journal of Structural Biology (2010)
Dendritic Assembly of Heteromeric gamma-Aminobutyric Acid Type B Receptor Subunits in Hippocampal Neurons Ramirez, OA; Vidal, RL; Tello, JA; Vargas, KJ; Kindler, S; Haertel, S; Couve, A Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Insulin Resistant Skeletal Muscle: Mitochondria Structure, Dynamics and Calcium Homeostasis Eisner V.; García, A; Härtel, S; Escobar, M; Casas, M; Aedo, P; Mears, D; Ezquer, M; Conget, P; Lavandero, S; Hidalgo, C; Jaimovich, E Article BIOPHYSICAL JOURNAL (2009)
Lipid domains in giant unilamellar vesicles and their correspondence with equilibrium thermodynamic phases: A quantitative fluorescence microscopy imaging approach Fidorra, M; Garcia, A.; Ipsen, JH; Hartel, S; Bagatolli, LA Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)
NADPH Oxidase and Hydrogen Peroxide Mediate Insulin-induced Calcium Increase in Skeletal Muscle Cells Espinosa, A.; Garcia, A.; Hartel, S; Hidalgo C.; Jaimovich E. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Sphingomyelinase-Induced Domain Shape Relaxation Driven by Out-of-Equilibrium Changes of Composition Fanani, ML; De Tullio, L; Hartel, S; Jara, J; Maggio, B Article ISI SCOPUS BIOPHYSICAL JOURNAL (2009)
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis Parra, V; Eisner V.; Chiong M.; Criollo, A; Moraga, F; Garcia, A.; Haertel, S; Jaimovich E.; Zorzano A; Hidalgo C.; Lavandero S. Article ISI SCOPUS CARDIOVASCULAR RESEARCH (2008)
Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible robe in cardioprotection Sánchez G; Escobar M.; Pedrozo, Z; Macho P; Domenech, R; Hartel, S; Hidalgo C.; Donoso P. Article ISI SCOPUS CARDIOVASCULAR RESEARCH (2008)
Marlin-1 and conventional kinesin link GABA(B) receptors to the cytoskeleton and regulate receptor transport Vidal, RL; Ramirez, OA; Sandoval L.; Koenig-Robert, R; Hartel, S; Couve, A Article ISI MOLECULAR AND CELLULAR NEUROSCIENCE (2007)
The initial surface composition and topography modulate sphingomyelinase-driven sphingomyelin to ceramide conversion in lipid monolayers De Tullio, L; Maggio, B; Hartel, S; Jara, J; Fanani, ML Article ISI SCOPUS CELL BIOCHEMISTRY AND BIOPHYSICS (2007)
ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload Castro J.; Ruminot, I; Porras, OH; Flores, CM; Hermosilla T.; Verdugo E.; Venegas, F; Hartel, S; Michea, L.; Barros, LF Article ISI SCOPUS CELL DEATH AND DIFFERENTIATION (2006)
Surface-bound phosphatase activity in ectomycorrhizal fungi: a comparative study between a colorimetric and a microscope-based method Alvarez M.; Gieseke, A; Godoy, R; Hartel, S Article ISI SCOPUS BIOLOGY AND FERTILITY OF SOILS (2006)
Anatomical-physiological determination of surface bound phosphatase activity in ectomycorrhizae of Nothofagus obliqua Alvarez M.; Godoy, R; Heyser, W; Hartel, S Article ISI SCOPUS SOIL BIOLOGY BIOCHEMISTRY (2005)
Shape transitions and lattice structuring of ceramide-enriched domains generated by sphingomyelinase in lipid monolayers Hartel, S; Fanani, ML; Maggio, B Article ISI SCOPUS BIOPHYSICAL JOURNAL (2005)
Surface-bound phosphatase activity in living hyphae of ectomycorrhizal fungi of Nothofagus obliqua Alvarez M.; Godoy, R; Heyser, W; Hartel, S Article ISI SCOPUS Mycologia (2004)
Ultraviolet exposure of thymocytes: selective inhibition of apoptosis Ojeda, F; Guarda, MI; Lovengreen, C; Hidalgo, MA; Folch H.; Hartel, S; Maldonado, C Article ISI SCOPUS INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2004)
NEW PERSPECTIVES ON THE DETERMINATION OF PHOSPHATASE ACTIVITY IN ECTOMYCORRHIZAE OF NOTHOFAGUS OBLIQUA FORESTS IN SOUTHERN CHILE Alvarez, Maricel; Härtel, Steffen; Godoy, Roberto; Heyser, Wolfgang Article SCIELO GAYANA BOTANICA (2003)
Staurosporine-induced apoptosis in human cornea epithelial cells in vitro Hartel, S; Zorn-Kruppa, M; Tykhonova, S; Alajuuma, P; Engelke, M; Diehl, HA Article ISI SCOPUS CYTOMETRY PART A (2003)
The susceptibility of non-UV fluorescent membrane dyes to dynamical properties of lipid membranes Hartel, S; Tykhonova, S; Haas, M; Diehl, HA Article ISI Journal of Fluorescence (2002)


Translational cancer research comes of age in Latin America Investigators of U.S. Latin America Cancer Research Network Article Science Translational Medicine (2015)
Trypanosoma cruzi Calreticulin Topographical Variations in Parasites Infecting Murine Macrophages Gonzalez A; Valck, C; Sánchez G.; Hartel, S; Mansilla J.; Ramirez, G.; Fernandez, MS; Arias, JL; Galanti, N; Ferreira A Article American Journal of Tropical Medicine and Hygiene (2015)
SOFI of GABAB neurotransmitter receptors in hippocampal neurons elucidates intracellular receptor trafficking and assembly Huss A, Ramírez OA, Santibañez F, Couve A, Härtel S, Enderlein J Article Proceedings of spie (2013)
Ciencia Computacional Aplicada a la Biomedicina Jara, Jorge; Histchfeld, Nancy; Härtel, Steffen Article Revista BITS de Ciencia (2012)
The action of sphingomyelinase in lipid monolayers as revealed by microscopic image analysis. Fanani, Maria Laura; Hartel, Steffen; Maggio, Bruno; De Tullio, Luisina; Jara, Jorge; Olmos, Felipe; Oliveira, Rafael Gustavo Article Biochimica et biophysica acta (2010)
3D Morpho-Topological Analysis of Asymmetric Neuronal Morphogenesis in Developing Zebrafish. S. Härtel, J. Jara, C.G. Lemus, M.L. Concha Article Computational Modelling of Objects Represented in Images. Fundamentals, Methods and Applications (2007)
The initial surface composition and topography modulate sphingomyelinase-driven sphingomyelin to ceramide conversion in lipid monolayers De Tullio L., Maggio B., Härtel S., Jara J. & Fanani ML. Article Cell Biochemistry and Biophysics (2007)
Phosphatase Activity in Ectomycorrhiza Fungi: A Comparative Study Between a Colorimetric and a Microscope-Based Method Alvarez M., Godoy R., Gieseke A., & Härtel S. Article Biology & Fertility of Soils (2006)
Anatomical-physiological determination of surface bound phosphatase activity in ectomycorrhiza of Nothofagus obliqua based on image processed confocal fluorescence microscopy Alvarez M., Godoy R., Heyser W., & Härtel S. Article Soil Biology and Biochemistry (2005)
Surface bound phosphatase activity in living hyphae of ectomycorrhizal fungi of Nothofagus obliqua Alvarez M., Godoy R., Heyser W., & Härtel S. Article Mycologia (2004)
Ceramide modulates the lipid membrane organization at molecular and supramolecular levels Carrer D., Härtel S., & Maggio B. Article Chemisty and Physics of Lipids (2003)
New Perspectives in the Determination of phoshatase activity in ectomycorrhiza of Nothofagus obliqua in forests of southern Chile Alvarez M., Härtel S. Godoy R., & Heyser W. Article Gayana (2003)
Bidirectional Control of Sphingomyelinase Activity and Surface Topography in Lipid Monolayers Fanani M., Härtel S., Oliveira R., & Maggio B. Article Biophysical Journal (2002)
Kinetics of apoptotic markers in exogeneously induced apoptosis of EL4 cells Jessel R., Haertel S., Socaciu C., Tykhonova S., & Diehl H. Article Journal of Cellular and Molecular Medicine (2002)
Carotenoids in 1,2-dipalmitoyl-sn-glycero-3-phosphoryl-choline liposomes: incorporation and effects on phase transition and vesicle size. Socaciu C., Jessel R., Härtel S., & Diehl H. Article Journal of Medical Biochemistry (2000)
Cholesterol induced variations of membrane dynamics related to the induction of apoptosis in mouse thymocytes Härtel S., Ojeda F., & Diehl H. Article International Journal of Radiation Biology (1998)
Methyl-beta-cyclodextrins and liposomes as water-soluble carriers for cholesterol incorporation into membranes and its evaluation by a microenzymatic fluorescence assay and membrane fluidity-sensitive dyes Härtel S., Diehl H., & Ojeda F. Journal Article PubMed Analytical Biochemistry (1998)


Physical Model of Collective Cell Migration in Zebrafish Gastrulation Marquez, S; Soto, R; Pulgar, E; Concha, M; Hartel, S Abstract ISI EUROPEAN BIOPHYSICS JOURNAL (2017)
Microtubule-associated protein 1B (MAP1B) regulates synaptic functions in mature neurons Bodaleo, F; Montenegro-Venegas, C; Court, F; Hartel, S; Gonzalez-Billault, C Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2013)
TRYPANOSOMA CRUZI INDUCES CELLULAR PROLIFERATION IN THE TROPHOBLASTIC CELL LINE BEWO Droguett, D; Liempi, A; Castillo C.; Duaso, J; Cerda M.; Hartel, S; Galanti N.; Maya, JD; Kemmerling U. Abstract ISI PLACENTA (2013)
TRYPANOSOMA CRUZI INDUCES DIFFERENTIATION OF THE TROPHOBLAST Castillo C.; Liempi, A; Droguett, D; Duaso, J; Cerda M.; Hartel, S; Galanti N.; Maya, JD; Kemmerling U. Abstract ISI PLACENTA (2013)
Comparative analysis of epiboly in teleost fish Reig G.; Hartel, S; Concha M. Abstract ISI MECHANISMS OF DEVELOPMENT (2009)
Linking organ formation to left-right patterning in the embryonic zebrafish Oteiza, P; Lemus, C; Koppen, M; Palma K.; Krieg M.; Melo, C; Farias, C; Pulgar E.; Preibisch, S; Hartel, S; Heisenberg, CP; Concha M. Abstract ISI MECHANISMS OF DEVELOPMENT (2009)
Wnt11/Pk1a-mediated planar cell polarity signalling orchestrates epithelial organ morphogenesis by regulating N-cadherin dependent cell adhesion forces Oteiza, P; Koeppen, M; Krieg M.; Preibisch, S; Haertel, S; Mueller, D; Heisenberg, CP; Concha M. Abstract ISI MECHANISMS OF DEVELOPMENT (2009)
Asymmetric morphogenesis of the parapineal organ in the developing zebrafish brain Lemus, CG; Hartel, S; Regan, J; Russel, C; Wilson S.; Concha, ML Abstract ISI DEVELOPMENTAL BIOLOGY (2007)


SOFI of GABAB neurotransmitter receptors in hippocampal neurons elucidates intracellular receptor trafficking and assembly Huss, A; Ramírez, O; Santibáñez, F; Couve, A; Hartel, S; Enderlein , J Conference Paper SCOPUS Progress in Biomedical Optics and Imaging - Proceedings of SPIE (2013)
3D morpho-topological analysis of asymmetric neuronal morphogenesis in developing zebrafish Hartel, S; Jara, J; Lemus, CG; Concha, ML ConferencePaper ISI COMPUTATIONAL MODELLING OF OBJECTS REPRESENTED IN IMAGES: FUNDAMENTALS, METHODS AND APPLICATIONS (2007)


The action of sphingomyelinase in lipid monolayers as revealed by microscopic image analysis Fanani, ML; Hartel, S; Maggio, B; De Tullio, L; Jara, J; Olmos, F; Oliveira, RG Review ISI SCOPUS Biochimica et Biophysica Acta - Biomembranes (2010)


Ciencia Computacional Aplicada a la Biomedicina Jara, J; Hitschfeld, N; Hartel, S Monograph (2012)

Steffen Hartel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Mauricio Cerda

Assistant Professor (appointed)

Programa de Anatomía y Biología del Desarrollo

UNIVERSIDAD DE CHILE

Santiago, Chile

Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Eduardo Pulgar

Postdoctorado

Departamento de Anatomía y Biología del Desarrollo

UNIVERSIDAD DE CHILE

Santiago, Chile

Ulrike Kemmerling

Associate Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

Juan Maya

Associated Proffesor

Instituto de Ciencias Biomedicas

UNIVERSIDAD DE CHILE

Santiago, Chile

Tatiana Adasme

Associate Professor, CIBQA Researcher

Associate Professor

Computer Science

UNIVERSIDAD DE CHILE , DEPTO CIENCIAS COMPUTACION

Santiago, Chile

Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Maria-Paz Marzolo

Profesor Asociado

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

Andrea Maturana

Academico

Patologia y Medicina Oral

Facultad de Odontologia

Santiago, Chile

Ignacio Niechi

Profesor Adjunto

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

JUAN AITKEN

PROFESOR ASISTENTE

PATOLOGIA Y MEDICINA ORAL

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

German Reig

Investigador Postdoctoral

Anatomía y Biología del Desarrollo

LABORATORIO DE ESTUDIOS ONTOGENETICOS. FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Lorena Lobos-Gonzalez

Principal Investigator-Prosesor Asociado

Facultad de Medicina - Clinica Alemana

Universidad Del Desarrollo

santiago, Chile

Maria Diaz

Part time Professor

Ciencias Quimicas y Biologicas

Universidad Bernado O´higgins

Santiago , Chile

Hery Urra

Postdoctorado

UNIVERSIDAD DE CHILE

Santiago, Chile

Rodrigo Assar

Adjoint Professor

Facultad de Medicina

Universidad de Chile

Santiago, Chile

Amelina Albornoz

Post doctorado

Virología Molecular

Fundación Ciencia & Vida

Santiago, Chile

Francisco Aguayo

Profesor Asociado

CENTRO INTERNACIONAL DE BIOMEDICINA (ICC)

Santiago, Chile

Maria Hidalgo

Associate professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Eugenia Diaz

Profesor Asistente

Facultad de Medicina

Universidad de Chile

Santiago, Chile

Denise Riquelme

Adjunct Professor

Biology

Universidad de Santiago

Santiago, Chile

Ulises Urzúa

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

INGE Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

Jose Delpiano

Profesor Asistente

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Hugo Folch

Professor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Steffen Hartel Grundler

Líneas de Investigación

Educación

Diploma in Physics, UNIVERSITAT BREMEN. Alemania, 1996

Dr rer nat Physics, UNIVERSITAT BREMEN. Alemania, 2000

Experiencia Académica

Assistant Professor Full Time

Associated Professor Full Time

Full Professor Full Time

Experiencia Profesional

Postdoc Full Time

Postdoc / Automatic Video-Analysis And Textual Annotation (Avanta) Full Time

Postdoc / Structure, Dynamics And Kinetics In Biomembranes And Necrobiological Processes Focussed Full Time

Postdoc / Mechanisms Of Apoptotic And Necrotic Cell Death: Time Resolved Multi-Parameter Analysis Full Time

Subdirector of Research, Instituto de Ciencias Biomedicas, Facultad de Medicina Other

Director of Center of Medical Informatics and Telemedicine, CIMT, Faculty of Medicine Full Time

Director, National Center for Health Information Systems, CENS, CTTS-66390 Part Time

Formación de Capital Humano

Premios y Distinciones

Academic Excellence in Research Medal

Iberoamerican award to innovation and entrepreneurship (SEGIB)

Academic Excellence in Research Medal

Innovative Vision award 100K 2011

Digital Thesis of the Year

Doctor José Tohá Castella

Feodor Lynen Fellowship

Special award for the Ph.D. thesis

Bremer Studienpreis for the best Ph.D. thesis in natural sciences of the year

Dissertation passed with Maximum Distinction summa cum laude

Travel & Investigation Grant, DAAD

Bremer Studienfonds e.V, Investigation Fellowship & Travel Fellowship, DAAD

Recognition for its Contribution to Research under the ISI-WOS 2017 Publication, entitled "Extra-Embryonic tissue spreading direct early embryo morphogenesis in killifish"

Recognition for its Contribution to Research under the Publication ISI-WOS 2017, entitled "Epigenetic editing of th Dlg4 / PSD95 gene improves cognition in aged and Alzheimer's disease mice"

Recognition for its Contribution to Research under the Publication ISI-WOS 2017, entitled "Directional asymmetry in the volume of the human habenula"

Recognition for its Contribution to Research under the Publication ISI-WOS 2017, "Extra-embryonic tissue spreading direct early embryo morphogenesis in killifish"

Recognition for its Contribution to Research under the award of the Fondecyt-Regular 2018 project, entitled "5D Image Processing and Physical Models for the Quantification of Cell Migration and Multicellular Architecture with 4-Lens Light Sheet Fluorescen

Special recognition for its contribution to the value that university internalization must play in the development of the University of Chile and the country

Article (61)

Article (17)

Abstract (8)

ConferencePaper (2)

Review (1)

Monograph (1)