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Luis Fernando Michea Acevedo

PROFESOR ASOCIADO

UNIVERSIDAD DE CHILE

Santiago, Chile

Hormonal regulation of ion transport in renal and cardiovascular tissue. Pathophysiology of hypertension and vascular calcification in chronic kidney failure. Immunological mechanism in hypertension and hypertension- target- organ damage.

CIENCIAS BIOMEDICAS, UNIVERSIDAD DE CHILE. Chile, 1996
MD, UNIVERSIDAD DE CHILE. Chile, 1991
Filosofía, UNIVERSIDAD DE LOS ANDES. Chile, 2006

PROFESOR ASISTENTE Full Time

UNIVERSIDAD DE CHILE

MEDICINA

SANTIAGO, Chile

2007 - 2010
DIRECTOR DE INVESTIGACION Y TECNOLOGIA Full Time

UNIVERSIDAD DE CHILE

MEDICINA

SANTIAGO, Chile

2007 - 2013
PROFESOR ASISTENTE Full Time

UNIVERSIDAD DE LOS ANDES

MEDICINA

SANTIAGO, Chile

1996 - 2002
PROFESOR ASOCIADO Full Time

UNIVERSIDAD DE LOS ANDES

MEDICINA

SANTIAGO, Chile

2002 - 2006
PROFESOR ASOCIADO Full Time

UNIVERSIDAD DE CHILE

MEDICINA

SANTIAGO, Chile

2010 - A la fecha

VISITING SCIENTIST Full Time

NATIONAL INSTITUTE OF HEALTH

Bethesda, Maryland, Estados Unidos

1998 - 2000
PROFESOR ASISTENTE Full Time

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1996 - 2002
PROFESOR ASOCIADO Full Time

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

2002 - 2006
PROFESOR ASISTENTE Full Time

UNIVERSIDAD DE CHILE

Santiago, Chile

2007 - 2010
DIRECTOR DE INVESTIGACION Y TECNOLOGIA Full Time

UNIVERSIDAD DE CHILE

Santiago, Chile

2007 - 2013
PROFESOR ASOCIADO Full Time

UNIVERSIDAD DE CHILE

Santiago, Chile

2010 - A la fecha

POSTDOCTORAL
Loreto Carrasco Alarcón. FONDECYT 3060026. Potential participation of vassopressin in cardiovascular damage induced by high salt intake and minerolcorticoids.

GRADUATE
Patricio Andrés Araos Salas. 2014. Renal dendritic cells are required for the development of arterial hypertension in response to Angiotensin II. PhD in Pharmacolgy. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile.
Pablo Andrés Diaz Molina Díaz. 2014. Role of the ?3 subunit of the Na+/K+ ATPase pump in sodium homeostasis and arterial hipertension PhD in Biochemistry. Universidad de Chile.
Daniel Enrique Hevia Magaña. 2014. Proinflammatory dendritic cells are required for damage induced by hipertension. PhD in Biomedical Sciences. Universidad de Chile.
Luis Alejandro Toro Cabrera. 2014. Protective effect of the FGF-23/Klotho/FGFR1 pathway in ischemic acute kidney injury. PhD in Biomedical Sciences and Speciality. Universidad de Chile.
Keigo Sugisawa. 2014. The Regulation of FGF23 in Acute Kidney Injury. Department of Human Pathology. Latin American Collaborative Research Center, Tokyo Medical and Dental University (TMDU), Clínica Las Condes- Universidad de Chile.
Daisuke Kawata. 2013. Role of FGFR1 Pathway in Acute Kidney Injury. Department of Human Pathology. Latin American Collaborative Research Center, Tokyo Medical and Dental University (TMDU),Clínica Las Condes- Universidad de Chile.
María Loreto Varela Morales. 2013. Effect of Angiotensin (1-9) in angiogenesis, via the AT2 receptor of Angiotensin II. Magister en Ciencias Biológicas y Médicas, mención Morfología. Universidad de Chile.
Juan Pedro Peña Mendez. 2013. Activation of Interleukin 17 via a mechanism of inflammation and cardiovascular damage induced by aldosterone. Magister en Ciencias Animales y Veterinarias. Mención Patología Animal. Facultad de Ciencias Veterinarias y Pecuarias. Universidad de Chile.
Cristián Alejandro Amador Carrasco. 2013. Activity of the mineralocorticoid receptor in cells from the immune system during cardiovascular and renal inflammation. PhD in Biomedical Sciences. Universidad de Chile.
Rafael Alonso Martínez Figueroa. 2012. Role of the inorganic phosphate cotransporter PiT-1 in the condroidea hypertrophy of ATDC5 cells exposed to synovial liquid of patients with osteoarthritis. PhD in Biomedical Sciences. Pontificia Universidad Católica de Chile.
Natalia Hilda Dünner Moreno. 2012. Studies on the mechanism of intracellular calcium levels and the proteolisis induced by the parathyroid hormone in uremic skeletal muscle. PhD in Biochemistry. Universidad de Chile.
Jessica Alejandra Díaz Elizondo . 2011. Aldosterone in peripheral blood mononuclear cells and cardiomyocytes: role of TNF-? and reactive oxygen species.PhD in Biochemistry. Universidad de Chile.
Alexis González Parra. 2009. Expression of the epithelial sodium channel (ENaC) in renin-angiotensin-aldosterone system and possible regulation mediated by Cox-2 in rat kidney. PhD in Physiological Sciences.

UNDERGRADUATE
Alvaro Plaza Valencia. 2014. Mineralocorticoid role in regulating subunit ?3 of the Na + / K + ATPase in rat ventricular myocardium. Biochemist . Universidad de Santiago de Chile.
María Ignacia Bunster Sobarzo. 2013. Activity of the mineralocorticoid receptor in cells from the immune system during cardiovascular and renal inflammation. Nutricionist. Universidad Andrés Bello de Chile.
María Paz Beltrán Salvo. 2011. Role of Connexin 43 in uremic rats. Biologist. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile.
Kathia Berczeller Nahum. 2007. Hormonal regulation of sodium-phospphate NaPi III cotransporter implicated in arteriosclerosis. Veterinary Doctor. Facultad de Ciencias Veterinarias y Pecuarias. Universidad de Chile.
Karla Carolina Pino Lemunao. 2006. Aldosterone effect on the expression of parathyroid hormone receptors in the cardiovascular system. Biochemist. Facultad de Ciencias Básicas y Matemáticas, Pontificia Universidad Católica de Valparaíso.
Andrea Alejandra Villagrán Torres. 2006. Potential aldosterone effect in the cardiovascular system of a experimental model for chronic renal failure. Biochemist. Facultad de Ciencias Básicas y Matemáticas, Pontificia Universidad Católica de Valparaíso.
Francisco Antonio Lisboa Galdames.2006. Hiperaldosteronism effect in experimental models for congestive heart failure over the imflamatory immune response.Biochemist. Facultad de Ciencias Básicas y Matemáticas, Pontificia Universidad Católica de Valparaíso.
Andrés Enrique González Gutiérrez. 2006. Sodium ephitelial channel (ENaC) activity in rat cardiac tissue and its modulation by beta 1 adrenergic agonist. Biochemist. Facultad de Ciencias Básicas y Matemáticas, Pontificia Universidad Católica de Valparaíso.
Francisco Roderick Pérez Contreras. 2006. Endothelial sodium epithelial channel (ENAC) modulates the arterial contraction from vascular resistance arteries in the rat. Biochemist. Facultad de Ciencias Básicas y Matemáticas, Pontificia Universidad Católica de Valparaíso.
Francisco Rafael Rojas Díaz. 2004. Regulation of the expression of NKCC1 cotransporter by aldosterone in cardiac tissue. Veterinary Doctor, Facultad de Ciencias Veterinarias y Pecuarias. Universidad de Chile.
Ana María Delpiano Barriga. 2004. Mineralocorticoids regulate the expression of potassium-chloride KCC3 cotransporter in blood vessels but with no effect in arterial tissue. Biochemist. Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile.
Natalia Dünner Moreno. 2003. Regulation by aldosterone of the genic expression of the NKCC1 cotransporter in cardiovascular tissueBiochemist. Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile.
Nandy Carolina López Bartolucci. 2002. Expression and regulation by suprarenal steroids of the K+-Cl- cotransporters in arterial tissue. Biochemist. Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Chile.

Young Research Investigator Award

Chilean Society of Nephrology

Chile, 2013

The fibroblast growth factor 23 presents early renal clearance and increase in experimental acute renal dysfunction.
Best Clinical Work Award

Chilean Society of Transplantation

Chile, 2013

Comparison of the diagnostic test of insulin resistance HOMA, ISI and TyG in pediatric renal transplantation
Research Investigator Award

Latin American Society of Nephrology and Hypertension and XVII Congress of the Colombian Association of Nephrology and Hypertension. 2012

Colombia, 2012

Stanniocalcin-1 increases expression in aorta of atherosclerotic animals and induce calcification in VSMC.
Young Investigator Award

XVth Congress of the International Society of Cardiovascular Pharmacotherapy

Chile, 2011

The blockade of interleukin-17 ameliorates the hypertension, and heart inflammation induced by Experimental hiperaldosteronism remodelation.
Best Research Work

Chilean Society of Transplantation

Chile, 2011

Mineral bone disease in renal transplantation : Role of FGF23-Klotho axis.
Best Work Basic Sciences

Chilean Societies of Nephrology, Hypertension and Transplant

Chile, 2011

High phosphate and vitamin D induces the expression of Stanniocalcin-1, a new hormone procalcificante in endothelial cells
Best Scientific Work

Chilean Societies of Nephrology, Hypertension and Transplant

Chile, 2011

Mineral bone disease in renal transplantation: Role of FGF23-Klotho axis
Best Basic Research

Chilean Societies of Nephrology, Hypertension and Transplant

Chile, 2010

The activation of aldosterone receptor promotes the polarization of the Th17 inflammatory pathway in DOCA-salt rats and dendritic cells in vitro.
Best Basic Research

Chilean Societies of Nephrology, Hypertension and Transplant

Chile, 2009

Aldosterone activates the inflammatory T helper17 pathway in DOCA-salt rats.
Best Basic Research

Chilean Societies of Nephrology, Hypertension and Transplant

Chile, 2008

Aldosterone directly induce the expression of the sodium-phosphate cotransporter and the osteocondrogenic transdifferentiation of the arterial wall
Young Investigator Award

Chilean Societies of Nephrology, Hypertension and Transplant

Chile, 2007

Sulprostone regulates expression of alpha - and ENaC -1 alpha subunit of the Na +, K +-ATPase pump in the renal medulla of rats infused with angiotensin II.
Best Basic Research

Chilean Societies of Nephrology, Hypertension and Transplant

Chile, 2007

The activity of endothelial nitric oxide synthase is modulated by ENaC present in the endothelium of arteries resistance.
Best Research Work

Chilean Societies of Nephrology, Hypertension and Transplant

Chile, 2006

Gene expression and activity of sodium-phosphate cotransporter in experimental vascular of CKD
Best Research Work

Chilean Societies of Nephrology, Hypertension and Transplant

Chile, 2005

Spironolactone action in the cardiovascular system uremic rats
Research Investigator Award

XVII Congreso de la Sociedad Latinoamericana de Nefrología e Hipertensión Arterial SLANH / VIII Congreso Iberoamericano de Nefrología / XXXI Congreso Conjunto de Sociedades Chilenas de Nefrología e Hipertensión

Chile, 2014

Dendritic cells are necessary for the development of hypertension and tissue damage in response to angiotensin II and diet rich in salt.
Research Investigator Award

XVII Congreso de la Sociedad Latinoamericana de Nefrología e Hipertensión Arterial SLANH / VIII Congreso Iberoamericano de Nefrología / XXXI Congreso Conjunto de Sociedades Chilenas de Nefrología e Hipertensión

Chile, 2014

Fibroblast Growth Factor 23 has presented early renal clearance and increase in experimental acute renal failure
Editorial Commentary

Hypertension

Estados Unidos, 2009

The (F) low Down on the Endothelial Epithelial Sodium Channel. Epithelial Sodium Channel as a Brake on Flow-Mediated Vasodilation
Invited Speaker

Symposium New Mechanisms in the Regulation of Vascular Function. Sociedad Chilena de Ciencias Fisiológicas

Chile, 2007

Epithelial sodium channel (ENaC) located in the endothelium regulates the production of NO.
Letter to the Editor

Hypertension

Estados Unidos, 2008

Response to Spironolactone Attenuates Oxidative Stress in Patients With Chronic Kidney Disease
Editorial Commentary

Hypertension

Estados Unidos, 2008

Cardiac benefits of Mineralocorticoid Receptor Inhibition in Renal Failure.
Invited Speaker

World Congress Nephrology

Brasil, 2007

Receptor-mediated Endocytosis Symposium
Editorial Commentary

Hypertension

Estados Unidos, 2005

Microvascular Effects of Aldosterone and Angiotensin Type 2 Receptors
Editorial Commentary

Endocrinology

Chile, 2005

Nongenomic Cardiovascular Actions of Aldosterone: A Receptor for All Seasons?
Latin American Scientist Award

American Society of Nephrology

Chile, 1998

Latin American Scientist, 1998, American Society of Nephrology, Washington DC, USA.
Young Investigator Award

Chilean Societies of Nephrology, Hypertension and Transplant

Chile, 2003

Spironolactone and potassium homeostasis in hemodialysis patients
Best Research Work

XXXV Chilean Congress Internal Medicine

Chile, 2014

El factor de crecimiento fibroblástico 23 es un potencial biomarcador de injuria renal aguda en pacientes críticos con sepsis: resultados preliminares de una cohorte prospectiva
The William E. Mitch, III, MD, FASN International Scholars

American Society of Nephrology.Annual Meeting at Kidney Week 2014.

Estados Unidos, 2014

Ablation of Dendritic Cells Prevents Hypertension in Mice Infused with Angiotensin II plus High Salt Diet.
Top Oral Abstracts by Trainees

ASN Kidney Week 2014 Annual Meeting

Chile, 2014

Ablation of Dendritic Cells Prevents Hypertension in Mice Infused with Angiotensin II plus High Salt Diet


Dendritic cells are crucial for cardiovascular remodeling and modulate neutrophil gelatinase-associated lipocalin expression upon mineralocorticoid receptor activation Araos, Patricio; Prado, Carolina; Lozano, Mauricio; Figueroa, Stefanny; Espinoza, Alexandra; Berger, Thorsten; Mak, Tak W.; Jaisser, Frederic; Pacheco, Rodrigo; Michea, Luis; Amador, Cristian A. Article ISI SCOPUS JOURNAL OF HYPERTENSION (2019)
Glucocorticoids Decrease Longitudinal Bone Growth in Pediatric Kidney Transplant Recipients by Stimulating the FGF23/FGFR3 Signaling Pathway Delucchi, Ángela; Toro, Luis; Alzamora, Rodrigo; Barrientos, Victor; González, Magdalena; Andaur, Rodrigo; León, Pablo; Villanueva, Francisco; Galindo, Mario; Heras, Facundo Las; Montecino, Martín; moena, daniel; Lazcano, Andrea; Pinto, Viola; Salas, Paulina; Reyes, María Loreto; Mericq, Verónica; Michea, Luis Article ISI SCOPUS JOURNAL OF BONE AND MINERAL RESEARCH (2019)
L-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice Pasten C.; Alvarado C.; Rocco J.; Contreras L.; Aracena P.; Liberona, J; Suazo C.; Michea L.; IrarrÃ¡zabal C.E. Article ISI SCOPUS American Journal Physiology-Renal Physiology (2019)
TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines Sagredo, Alfredo I.; Sagredo, Eduardo A.; Pola, Victor; Echeverria, Cesar; Andaur, Rodrigo; Michea, Luis; Stutzin, Andres; Simon, Felipe; Marcelain, Katherine; Armisen, Ricardo Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Erythropoietin induces bone marrow and plasma fibroblast growth factor 23 during acute kidney injury Toro, Luis; Barrientos, Víctor; León, Pablo; Rojas, Macarena; Gonzalez, Magdalena; González-Ibáñez, Alvaro; Illanes, Sebastián; Sugikawa, Keigo; Abarzúa, Néstor; Bascuñán, César; Arcos, Katherine; Fuentealba, Carlos; Tong, Ana María; Elorza, Alvaro A.; Pinto, María Eugenia; Alzamora, Rodrigo; Romero, Carlos; Michea, Luis Article ISI SCOPUS KIDNEY INTERNATIONAL (2018)
Myeloid CD11c(+) Antigen-Presenting Cells Ablation Prevents Hypertension in Response to Angiotensin II Plus High-Salt Diet Michea, Luis; Alzamora, Rodrigo; Hevia, Daniel; Cifuentes-Araneda, Flavia; Prado, Carolina; Gonzalez, Alexis A.; Rojas, Macarena; Amador, Cristian A.; Fuentes Luppichini, Eugenia; Pacheco, Rodrigo; Araos, Patricio Article ISI SCOPUS HYPERTENSION (2018)
Mineralocorticoids modulate the expression of the-3 subunit of the Na+, K+-ATPase in the renal collecting duct Rojas, Macarena; D?az, Pablo; Le?n, Pablo; Gonz?lez, Alexis A.; Gonz?lez, Magdalena; Barrientos, V?ctor; Pestov, Nikolay B.; Alzamora, Rodrigo; Michea, Luis Article ISI SCOPUS CHANNELS (2017)
Tumor-induced osteomalacia: experience from a South American academic center González, G.; Baudrand, R.; Sepúlveda, M. F.; Vucetich, N.; Guarda, F. J.; Villanueva, P.; Contreras, O.; Villa, A.; Salech, F.; Toro, L.; Michea, L.; Florenzano, P. Article ISI SCOPUS OSTEOPOROSIS INTERNATIONAL (2017)
The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A Rivas, S.; Armisen, R; Rojas, DA; Maldonado E.; Huerta, H.; Tapia, JC; Espinoza J.; Colombo, A; Michea, L.; Hayman, MJ; Marcelain, K Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2016)
Excess Iodide Induces an Acute Inhibition of the Sodium/Iodide Symporter in Thyroid Male Rat Cells by Increasing Reactive Oxygen Species Arriagada, AA; Albornoz, E; Opazo, MC; Becerra, A; Vidal G.; Fardella, C.; Michea, L.; Carrasco N.; Simon F.; Elorza, AA; Bueno, SM; Kalergis, AM; Riedel, CA Article ISI SCOPUS Endocrinology (2015)
Overexpression of connexin 43 reduces melanoma proliferative and metastatic capacity Tittarelli, A; Guerrero, I.; Tempio F.; GLEISNER, MA; Avalos, I.; Sabanegh, S.; Ortiz, C.; Michea, L.; López MN; Mendoza-Naranjo, A; SALAZAR ONFRAY F Article ISI SCOPUS British Journal of Cancer (2015)
The Expression of RAC1 and Mineralocorticoid Pathway-Dependent Genes are Associated With Different Responses to Salt Intake Tapia-Castillo, A; Carvajal, CA; Campino C.; Hill, C; Allende, F; Vecchiola, A; Carrasco C.; Bancalari, R; Valdivia C.; Lagos C.; Martinez-Aguayo, A; García H.; Aglony, M; Baudrand, RF; Kalergis, AM; Michea LF; Riedel, CA; Fardella, CE Article ISI SCOPUS American Journal of Hypertension (2015)
Vascular mineralocorticoid receptor and blood pressure regulation Tarjus, A; Amador, C; Michea, L.; Jaisser, F Article ISI SCOPUS Current Opinion in Pharmacology (2015)
Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis Ocaranza, Maria Paz; Moya, Jackeline; Barrientos, Victor; Alzamora, Rodrigo; Hevia, Daniel; Morales, Cristobal; Pinto, Melissa; Escudero, Nicolas; Garcia, Lorena; Novoa, Ulises; Ayala, Pedro; Diaz-Araya, Guillermo; Godoy, Ivan; Chiong, Mario; Lavandero, Sergio; Jalil, Jorge E.; Michea, Luis Article ISI SCOPUS JOURNAL OF HYPERTENSION (2014)
Reply: dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure Ocaranza, Maria Paz; Michea, Luis; Chiong, Mario; Lavandero, Sergio; Jalil, Jorge E. Article ISI JOURNAL OF HYPERTENSION (2014)
Spironolactone Decreases DOCA-Salt-Induced Organ Damage by Blocking the Activation of T Helper 17 and the Downregulation of Regulatory T Lymphocytes Amador, Cristian A; Barrientos, Victor; Peña, Juan; Herrada, Andres A.; Gonzalez, Magdalena; Valdes, Solange; Carrasco, Loreto; Alzamora, Rodrigo; Figueroa, Fernando; Kalergis, Alexis M; Michea, Luis Article ISI SCOPUS HYPERTENSION (2014)
Steroid Withdrawal in Pediatric Kidney Transplant Allows Better Growth, Lipids and Body Composition: A Randomized Controlled Trial Mericq,V., Salas, P., Pinto, V., Cano, F., Reyes, L., Brown, K., Gonzalez, M., Michea, L., Delgado, I., Delucchi, A Article ISI SCOPUS Hormone Research in Paediatrics (2013)
Assesment of arterial damage by noninvasive peripheral arterial tonometry in non-diabetic hemodialysis patients Espinoza F.; Kunstmann, S; Urzúa, A; Michea, L.; Marusic, ET; Vukusich A. Article ISI REVISTA MEDICA DE CHILE (2012)
Daño arterial asociado a la enfermedad renal crónica: evaluación mediante técnicas de laboratorio no invasivo en pacientes hemodializados Espinoza F.; Kunstmann, S; Urzúa, A; Michea, L.; Marusic E.T.; Vukusich A. Article SCIELO SCOPUS REVISTA MEDICA DE CHILE (2012)
IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction Avalos A.M.; Apablaza F.A.; Quiroz M.; Toledo, V.; Pena J.P.; Michea, L.; Irarrázabal C.E.; Carrion F.A.; Figueroa F.E. Article ISI SCIELO SCOPUS Biological Research (2012)
Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia Perez-Sepulveda, A; Torres, M. J.; Valenzuela F. J.; Larrain, R; Figueroa-Diesel, H; Galaz J.; Nien, J. K.; Serra R.; Michea, L.; Illanes, S. E. Article ISI SCOPUS Prenatal Diagnosis (2012)
NFAT5 Is Activated by Hypoxia: Role in Ischemia and Reperfusion in the Rat Kidney Villanueva, S.; Suazo, C; Santapau, D; Pérez F.; Quiroz M.; Carreno, J.E.; Illanes, S; Lavandero S.; Michea, L.; Irarrázabal C.E. Article ISI SCOPUS PLOS ONE (2012)
Homeostatic NMDA receptor down-regulation via brain derived neurotrophic factor and nitric oxide-dependent signalling in cortical but not in hippocampal neurons Sandoval, R; González A; Caviedes A; Pancetti F.; Smalla, KH; Kaehne T,; Michea, L.; Gundelfinger ED; Wyneken, U Article ISI SCOPUS Journal of Neurochemistry (2011)
A Randomized, Double-Blind, Placebo-Controlled Trial of Spironolactone on Carotid Intima-Media Thickness in Nondiabetic Hemodialysis Patients Vukusich A.; Kunstmann, S; Varela C.; Gainza, D; Bravo S.; Sepulveda D.; Cavada, G; Michea, L.; Marusic, ET Article ISI SCOPUS Clinical Journal of the American Society of Nephrology (2010)
Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity Herrada, AA; Contreras, FJ; Marini, NP; Amador CA; Gonzalez PA; Cortes, CM; Riedel, CA; Carvajal, CA; Figueroa F.; Michea LF; Fardella, CE; Kalergis, AM Article ISI SCOPUS Journal of Immunology (2010)
Cardiovascular assessment of non diabetic patients on hemodialysis Kunstmann, S; Vukusich A.; Michea, L.; Varela C.; Allende, I; Bravo S.; Gainza, D; Sepulveda D.; Marusic, E; Figueroa F. Article ISI REVISTA MEDICA DE CHILE (2009)
E Prostanoid-1 receptor regulates renal medullary alpha ENaC in rats infused with angiotensin II Gonzalez, AA; Cespedes, C; Villanueva, S.; Michea, L.; Vio, CP Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Endothelial Epithelial Sodium Channel Inhibition Activates Endothelial Nitric Oxide Synthase via Phosphoinositide 3-Kinase/Akt in Small-Diameter Mesenteric Arteries Perez, FR; Venegas, F; Gonzalez, M.; Andres S; Vallejos C.; RIQUELME, G; Sierralta, J; Michea, L. Article ISI SCOPUS HYPERTENSION (2009)
Evolución del compromiso cardiovascular de pacientes insuficientes renales, en hemodiálisis, sin bloqueo del eje renina-angiotensina Kunstmann, Sonia; Vukusich, Antonio; Michea, Luis; Varela, Cristián; Allende, Irene; Bravo, Sebastián; Gainza, Daniela; Sepúlveda, Daniela; Marusic, Elisa; Figueroa, Fernando Article SCIELO REVISTA MEDICA DE CHILE (2009)
Increased free fetal DNA levels in early pregnancy plasma of women who subsequently develop preeclampsia and intrauterine growth restriction Illanes, S; Parra,M; Serra R.; Pino, K; Figueroa-Diesel, H; Romero C.; Arraztoa JA; Michea, L.; Soothill, PW Article ISI SCOPUS PRENATAL DIAGNOSIS (2009)
Regulation of the Sodium-Phosphate Cotransporter Pit-1 and its Role in Vascular Calcification Gonzalez, M.; Martínez R.; Amador, C; Michea, L. Article CURRENT VASCULAR PHARMACOLOGY (2009)
Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and prevents oxidative stress in uremic rats Michea, L.; Villagrán A.; Urzúa, A; Kuntsmann, S; Venegas P.; CARRASCO L.; Gonzalez, M.; Marusic, ET Article ISI SCOPUS HYPERTENSION (2008)
ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload Castro J.; Ruminot, I; Porras, OH; Flores, CM; Hermosilla T.; Verdugo E.; Venegas, F; Hartel, S; Michea, L.; Barros, LF Article ISI SCOPUS CELL DEATH AND DIFFERENTIATION (2006)
Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells Cai Q.; Dmitrieva N.I.; Ferraris, J. D.; Michea L.F.; Fenton R.A.; Burg, M. B.; Salvador J.M.; Hollander M.C.; Fornace Jr. A.J. Article SCOPUS American Journal of Physiology - Renal Physiology (2006)
Na+-K+-2Cl(-) cotransporter is implicated in gender differences in the response of the rat aorta to phenylephrine Palacios J.; Espinoza F.; Munita C.; Cifuentes F.; Michea, L. Article ISI SCOPUS BRITISH JOURNAL OF PHARMACOLOGY (2006)
Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels Michea, L.; Delpiano, AM; Hitschfeld, C; Lobos, L; Lavandero S.; Marusic, ET Article SCOPUS ENDOCRINOLOGY (2005)
High-salt diet inhibits expression of angiotensin type 2 receptor in resistance arteries Gonzalez, M.; Lobos, L; Castillo, F.; Galleguillos L.; Lopez, NC; Michea, L. Article ISI SCOPUS HYPERTENSION (2005)
Effect of spironolactone on K+ homeostasis and ENaC expression in lymphocytes from chronic hemodialysis patients Michea, L.; Vukusich A.; Gonzalez, M.; Zehnder C.; Marusic, ET Article ISI SCOPUS KIDNEY INTERNATIONAL (2004)
Estradiol-induced expression of Na+-K+-ATPase catalytic isoforms in rat arteries: gender differences in activity mediated by nitric oxide donors Palacios J.; Marusic, ET; Lopez, NC; Gonzalez, M.; Michea, L. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)
cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion Brooks, Heddwen L.Ageloff S, Kwon TH, Brandt W, Terris JM, Seth A, Michea L, Nielsen S, Fenton R, Knepper MA Article SCOPUS American Journal of Physiology. Renal Physiology (2003)
Nongenomic effect of aldosterone on Na+,K+-adenosine triphosphatase in arterial vessels Alzamora, R; Marusic, ET; Gonzalez, M.; Michea, L. Article ISI SCOPUS ENDOCRINOLOGY (2003)
Regulation of KCI cotransport (KCC) isoforms expression and activity by aldosterone in vascular tissue. Michea LF; Lopez, NC; Marusic, ETM Article JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)
Toxicity of acetaminophen, salicylic acid, and caffeine for first-passage rat renal inner medullary collecting duct cells Cai Q.; Dmitrieva N.I.; Michea L.F.; Rocha, G.; Ferguson D.; Burg, M. B. Article SCOPUS JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Mitochondrial dysfunction is an early event in high-NaCl-induced apoptosis of mIMCD3 cells Michea, Luis F.,Combs C, Andrews P, Dmitrieva N, Burg MB Article SCOPUS American Journal of Physiology. Renal Physiology (2002)
Proliferation and osmotic tolerance of renal inner medullary epithelial cells in vivo and in cell culture Zhang Z.; Cai Q.; Michea, L.; Dmitrieva, NI; Andrews P.; Burg, MB Article ISI SCOPUS American Journal Physiology-Renal Physiology (2002)
Rate of increase of osmolality determines osmotic tolerance of mouse inner medullary epithelial cells Cai Q.; Michea, L.; Andrews P.; Zhang Z.; Rocha, G.; Dmitrieva, N; Burg, MB Article ISI SCOPUS American Journal Physiology-Renal Physiology (2002)
Three GADD45 isoforms contribute to hypertonic stress phenotype of murine renal inner medullary cells Chakravarty, D; Cai Q.; Ferraris, JD; Michea, L; Burg, MB; Kultz, D Article ISI American Journal Physiology-Renal Physiology (2002)
Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells Rocha, Gerson M.,Michea, LF., Peters, EM., Kirby, M., Xu, Y., ferguson, DR.,Burg, MB., Article SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
p53 Protects renal inner medullary cells from hypertonic stress by restricting DNA replication Dmitrieva, Natalia; Michea, Luis; Burg, Maurice Article American Journal of Physiology-Renal Physiology (2001)
Reduced Na-K pump but increased Na-K-2Cl cotransporter in aorta of streptozotocin-induced diabetic rat Michea, L.; Irribarra V.; Goecke, A; Marusic, ET Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2001)
Effect of casein-derived peptides on D-xylose absorption assessed by H-2 breath test in normal volunteers Defilippi C.; Madrid, AM; Salas K; Michea, L.; Lagos, N. Article ISI SCOPUS DIGESTIVE DISEASES AND SCIENCES (2000)
Genomic and non-genomic effects of mineralocorticoids in vascular smooth muscle Marusic, ET; Alzamora, R; Michea, L. Article JOURNAL OF PHYSIOLOGY-LONDON (2000)
Protection of renal inner medullary epithelial cells from apoptosis by hypertonic stress-induced p53 activation Dmitrieva, N; Kultz, D; Michea, L; Ferraris, J; Burg, M Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Regulation of aquaporin-2 trafficking by vasopressin in the renal collecting duct. Roles of ryanodine-sensitive Ca2+ stores and calmodulin Chou, Chunglin, Yip KP, Michea L, Kador K, Ferraris JD, Wade JB, Knepper MA Article SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Role of 11 beta-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries Alzamora, R; Michea, L.; Marusic, ET Article ISI HYPERTENSION (2000)
Toxic effects, pharmacokinetics and clearance of saxitoxin, a component of paralytic shellfish poison (PSP), in cats Andrinolo, D; Lagos, N.; Michea L.F. Article TOXICON (1999)
Adrenal-dependent modulation of the catalytic subunit isoforms of the Na+-K+-ATPase in aorta Michea, L.; Valenzuela, V.; Bravo, I; Schuster, A; Marusic E.T. Article AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (1998)
Comparison of extra renal potassium disposal in hypertensive, diabetic and normal subjects Michea, Luis F.,Alvo, M., Morales, H., Brito, J., Peters, G., Marusic, ET. Article SCOPUS REVISTA MEDICA DE CHILE (1997)
Biochemical evidence for adhesion-promoting role of major intrinsic protein isolated from both normal and cataractous human lenses Michea ,LF., Andrinolo, D., Ceppi, H., Lagos,N. Article SCOPUS EXPERIMENTAL EYE RESEARCH (1995)
Lens major intrinsic protein (MIP) promotes adhesion when reconstituted into large unilamellar liposomes Michea Luis F., de la Fuente, M., Lagos, N. Article SCOPUS BIOCHEMISTRY (1994)
Effect of chronic renal failure on Na,K-ATPase alpha 1 and alpha 2 mRNA transcription in rat skeletal muscle. Bonilla, S., Goecke, IA., Bozzo, I., Alvo, M., Michea, L., Marusic, ET. Article Scopus JOURNAL OF CLINICAL INVESTIGATION (1991)


BIOMARKERS IN ACUTE REJECTION IN PEDIATRIC KIDNEY TRANSPLANTATION Hevia D; Busnter, MI; Delucchi, A; Cano, F; Pinto, V; Salas P.; Gonzalez, M.; Michea, L. Abstract PEDIATRIC TRANSPLANTATION (2011)
PROTOCOL BIOPSY AND BIOMARKERS OF ACUTE REJECTION IN PEDIATRIC KIDNEY TRANSPLANTATION Pinto, V; Salas P.; Hevia D; Hernández J.; Elgueta S.; Contreras, L. ; Cano, F; Gonzalez, M.; Michea, L.; Delucchi, A Abstract PEDIATRIC TRANSPLANTATION (2011)
STEROID WITHDRAWAL IMMUNOSUPPRESSION IN FGF23/KLOTHO AND IGF-I/IGFBP3 AXIS IN PEDIATRIC KIDNEY TRANSPLANTATION Delucchi, A; Dinamarca, H; Cano, F; Pinto, V; Salas P.; Gonzalez, M.; Mericq V.; Iñiguez G.; Hevia D; Michea, L. Abstract PEDIATRIC TRANSPLANTATION (2011)
Biomarkers in Early Acute Rejection in Pediatric Renal Transplantation Delucchi, A; Bunster, MI; Gonzalez, M.; Cano, F; Pinto, V; Salas P.; Michea, L. Abstract PEDIATRIC NEPHROLOGY (2010)
Cardiovascular morbimortality in End Stage Renal Disease patients: Effect of spironolactone Gainza, D; Kunstmann, S; Marusic, E; Vukusich A.; Michea, L.; Varela C.; Sepulveda D.; Bravo S. Abstract CIRCULATION (2008)
Cardiac expression of degenerin/epithelial sodium channel proteins and potential modulation by mineralocorticoids Venegas, F; Varela, N; Michea, L. Abstract PLACENTA (2006)
Effect of vasopressin and DOCA-salt in 11(beta)over-barhydroxysteroid deshydrogenase type 2 and mineralocorticoid receptor expression in cardiac tissue CARRASCO L.; Michea, L. Abstract PLACENTA (2006)
Functional and structural cardiac responses to spironolactone in uremic rats Michea, L.; Kunstmann, S; Urzúa, A; Villagrán A.; Venegas P.; Marusic, E Abstract ISI ATHEROSCLEROSIS SUPPLEMENTS (2006)
Non diabetic end stage renal disease patients in chronic hemodialysis have high prevalence of cardiovascular damage Michea, L.; Kunstmann, S; Vukusic, A; Alliende I.; Varela C.; Gainza, D; Bravo S.; Sepulveda D.; Marusic, E Abstract ISI ATHEROSCLEROSIS SUPPLEMENTS (2006)
Proinflammatory cytokines and cardiovascular damage in chronic hemodialysis patients Michea, L.; Valenzuela, SV; Carron, F; Ibarra P.; Vukusich A.; Alliende I.; Figueroa F. Abstract PLACENTA (2006)
Adrenal steroids regulate the KCl cotransporter KCC4 isoform expression in cardiac muscle López N.; Mount, DB; Michea LF Abstract HYPERTENSION (2002)
Modulatory role of 11 beta-hydroxysteroid dehydrogenase on rapid effects of adrenocorticosteroids in vascular tissue Alzamora, R; Michea, L.; Aguirre, C; Marusic, ET Abstract JOURNAL OF PHYSIOLOGY-LONDON (2000)


Fisiología de la mama en la era molecular Michea, L.,Illanes S.; Arraztoa, J BookSection
Sistema Renina Angiotensina Aldosterona Michea, L.; Gordillo G, Exeni RA, de la Cruz J BookSection
Sistema Renina Angiotensina Aldosterona: concepto clásico y nuevos paradigmas. Michea, L.; G Gordillo, R. Exeni, J de la Cruz. BookSection


Dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure Reply Ocaranza, MP; Michea, L.; Chiong M.; Lavandero S.; JALIL, JE Letter ISI SCOPUS JOURNAL OF HYPERTENSION (2014)
Response to Spironolactone Attenuates Oxidative Stress in Patients With Chronic Kidney Disease Michea, L.; Marusic, ET Letter ISI HYPERTENSION (2008)


Validación de un Biomarcador Combinado para el Diagnóstico Precoz de Injuria Renal Aguda: Estudio Clínico Prospectivo Multicéntrico Michea, Luis; Luis Toro C. Proyecto (2020)
DIETARY CHLORIDE IN THE DEVELOPMENT OF HYPERTENSION: A NEW PLAYER REGULATING INTRARENAL RENIN-ANGIOTENSIN SYSTEM AND DENDRITIC CELL ACTIVITY? Michea, Luis; Alzamora, Rodrigo; Stutzin, Andres Proyecto (2017)
Dietary chloride in the development of hypertension=> a new player regulating intrarenal renin-angiotensin system and dendritic cell activity? FONDECYT (1171869) Proyecto 2017-2020 Inv. Responsable
REGULATION OF RENAL TUBULAR SODIUM REABSORPTION BY AMP-ACTIVATED PROTEIN KINASE ON ANGIOTENSIN II-INDUCED HYPERTENSION. FONDECYT (1151423) Proyecto 2015-2019 Coinvestigador(a)
ROLE IN SODIUM HOMEOSTASIS AND HYPERTENSION OF A NOVEL MOLECULAR MECHANISM THAT MEDIATES THE ACTION OF ALDOSTERONE IN TARGET TISSUES=> REGULATION OF THE BETA-3 SUBUNIT OF THE SODIUM PUMP. FONDECYT (1130550) Proyecto 2013-2017 Inv. Responsable
Instituto Milenio Inmunología e Inmunoterapia Kalergis-Parra, Alexis; Michea, Luis Proyecto (2011)
Instituto Milenio Inmunología e Inmunoterapia Iniciativa Milenio (P09-016-F) Proyecto 2011-2020 Inv. Responsable
THE INCRETIN GLUCAGON-LIKE PEPTIDE I=> STUDY OF NEW METABOLIC MECHANISMS IN VASCULAR REMODELING FONDECYT (1110180) Proyecto 2011-2014 Coinvestigador(a)
ANGIOTENSIN-(1-9)=> A NEW PEPTIDE REGULATOR OF BLOOD PRESSURE THAT DECREASES CARDIOVASCULAR REMODELING AND RENAL INJURY FONDECYT (1100874) Proyecto 2010-2014 Coinvestigador(a)
Pro-inflammatory conditions increase the permeability of the cell membrane through pathways that offer new therapeutic targets for human diseases Sáez, Juan Carlos; Michea, Luis Proyecto (2010)
Pro-inflammatory conditions increase the permeability of the cell membrane through pathways that offer new therapeutic targets for human diseases CONICYT (ACT71) Proyecto 2010-2013 Inv. Principal
MECANISMOS DE ARTERIOESCLEROSIS EN LA INSUFICIENCIA RENAL CRONICA=> REGULACION DE LOS TRANSPORTADORES DE FOSFATO Y TRANSDIFERENCIACION DEL MUSCULO LISO POR ALDOSTERONA Y LEPTINA FONDECYT (1090223) Proyecto 2009-2013 Inv. Responsable
Millennium Nucleus on Immunology and Immunotherapy Iniciativa Milenio (P07/088-F) Proyecto 2009-2011 Inv. Responsable
Centro FONDAP, Centro Estudios Moleculares de la Célula FONDAP (FONDAP 15010006) Proyecto 2007-2012 Inv. Principal
Centro FONDAP, Centro Estudios Moleculares de la Célula Stutzin, Andres; Hidalgo, Cecilia; Quest, Andrew; Jaimovich, Enrique; Hetz, Claudio; Michea, Luis; Lavandero, Sergio Proyecto (2007)
ESTADO INMUNOLOGICO PROINFLAMATORIO MEDIADO POR ALDOSTERONA. ESTUDIO CLINICO Y EXPERIMENTAL DE LA FUNCION INMUNE Y ENDOTELIAL EN EL DANO CARDIOVASCULAR INDUCIDO POR HIPERALDOSTERONEMIA FONDECYT (1050265) Proyecto 2005-2008 Coinvestigador(a)
MECANISMOS DE CARDIOPROTECCION DE ANTAGONISTAS DE ALDOSTERONA Y SU ACCION EN EL DANO CARDIOVASCULAR DE LA IRC=>ESTUDIOS CLINICOS Y EXPERIMENTALES. FONDEF (1050690) Proyecto 2005-2009 Inv. Responsable
POTENCIAL PARTICIPACION DE VASOPRESINA EN EL DANO CARDIOVASCULAR INDUCIDO POR ALTA INGESTA DE SAL Y MINERALOCORTICOIDES. FONDECYT (3060026) Proyecto 2005-2007 Inv. Patrocinante
MECANISMOS DE CARDIOPROTECCION DE ANTAGONISTAS DE ALDOSTERONA Y SU ACCION EN EL DAÃ‘O CARDIOVASCULAR DE LA INSUFICIENCIA RENAL CRONICA=>ESTUDIOS CLINICOS Y EXPERIMENTALES. FONDECYT (1040338) Proyecto 2004-2007 Coinvestigador(a)
REGULACION HORMONAL DE TRANSPORTADORES IONICOS DEL MUSCULO LISO VASCULAR Y SU EFECTO EN LA CONTRACTILIDAD Y PROLIFERACION CELULAR. FONDECYT (1010185) Proyecto 2001-2005 Inv. Responsable
REGULACION HORMONAL DE LOS TRANSPORTES VASCULARES DE SODIO Y SU RELACION CON LA REACTIVIDAD VASCULAR FONDECYT (1970696) Proyecto 1997-2000 Coinvestigador(a)
SEPARACION Y PURIFICACION DE FRACCIONES DE POLIPEPTIDOS DE LA CASEINA, ESTUDIO DE SU EFECTO EN LA ABSORCION, MOTILIDAD Y TRANSITO DEL INTESTINO DELGADO FONDECYT (1961213) Proyecto 1996-1999 Coinvestigador(a)
PURIFICACION DE DOS PROTEINAS INTRINSECAS DE MEMBRANA PRESENTES EN CRISTALINOS DE MAMIFEROS. FONDECYT (2930001) Proyecto 1993-1996 Inv. Responsable
ACOPLAMIENTO ESTIMULO-PERMEABILIDAD=> ROL DE HORMONAS POLIPEPTIDICAS Y DE MENSAJEROS CELULARES. FONDECYT (1880053) Proyecto 1988-1991 Coinvestigador(a)
ANGIOTENSIN-(1-9): A NEW PEPTIDE REGULATOR OF BLOOD PRESSURE THAT DECREASES CARDIOVASCULAR REMODELING AND RENAL INJURY Ocaranza, Maria; Michea, Luis Proyecto (0)
REGULATION OF RENAL TUBULAR SODIUM REABSORPTION BY AMP-ACTIVATED PROTEIN KINASE ON ANGIOTENSIN II-INDUCED HYPERTENSION Alzamora, Rodrigo; Michea, Luis Proyecto (0)
ROLE IN SODIUM HOMEOSTASIS AND HYPERTENSION OF A NOVEL MOLECULAR MECHANISM THAT MEDIATES THE ACTION OF ALDOSTERONE IN TARGET TISSUES: REGULATION OF THE BETA-3 SUBUNIT OF THE SODIUM PUMP Michea, Luis; Alzamora, Rodrigo Proyecto (0)
THE INCRETIN GLUCAGON-LIKE PEPTIDE I: STUDY OF NEW METABOLIC MECHANISMS IN VASCULAR REMODELING Chiong, Mario; Michea, Luis Proyecto (0)


Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system Ocaranza, Maria Paz; Michea, Luis; Chiong, Mario; Lagos, Carlos F; Lavandero, Sergio; Jalil, Jorge E. Review ISI SCOPUS CLINICAL SCIENCE (2014)
Influence of glucose metabolism on vascular smooth muscle cell proliferation Chiong M.; Morales PE; Torres, G; Gutiérrez T.; Garcia, L.; Ibacache M.; Michea, L. Review ISI SCOPUS Vasa - Journal of Vascular Diseases (2013)
Aldosterone as a modulator of immunity: implications in the organ damage Herrada, AA; Campino C.; Amador CA; Michea LF; Fardella, CE; Kalergis, AM Review ISI SCOPUS Journal of Hypertension (2011)

Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

Antonio Vukusich

Decano Facultad de Medicina

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

Cristián Amador

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Rodrigo Alzamora

ASSISTANT PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD DE CHILE

Santiago, Chile

Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Francisco Espinoza

Profesor Asistente

Medicina Interna

Universidad de los Andes

Santiago, Chile

Luis Toro

Profesor Asistente

Departamento de Medicina

Universidad de Chile

Santiago, Chile

Pablo León

Asistente de Investigación

Ciencias Biomedicas

Universidad de Chile

Santiago, Chile

Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Nestor Lagos

Full Professor

Fisiología y Biofísica

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

SANTIAGO, Chile

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

Alvaro Elorza

FULL PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

Maria Mericq

Profesor Titular

IDIMI

Universidad de Chile

Santiago, Chile

Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

Jimena Sierralta

Full Professor

Neuroscience

Faculty of Medicine, Universidad de Chile

Santiago, Chile

daniel hevia

Investigador PhD

Inmunologia

Universidad de Chile

santiago, Chile

Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Alexis Gonzalez

Adjunct Professor

Instituto de Química

Pontificia Universidad Católica de Valparaiso

Valparaíso, Chile

Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

Clemente Palacios

Académico

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

Patricio Araos

Profesor Asistente

Fisiología

Universidad Autónoma de Chile

Santiago, Chile

JORGE JALIL

FULL PROFESSOR

ENFS CARDIOVASCULARES

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE MEDICINA

Santiago, Chile

Pablo Díaz

Professional/Scientific advisor

Scientific Affairs

Instituto de Salud Públida de Chile

santiago, Chile

Alvaro Gonzalez

Chief Technology Officer

Cellter

Santiago, Chile

Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

Eduardo Sagredo

Pablo Florenzano

Instructor

Endocrinologia

Pontificia Universidad Católica de Chile

Santiago, Chile

Hernán Huerta

Asistente de Investigación

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Juan Peña

Director Medico

Servicios Veterinarios especializados VETCO

santiago, Chile

Alejandro Martinez

Profesor Asociado

Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago de Chile, Chile

Viola Pinto

Jefe

Hospital de niños Dr. Exequiel González Cortés

Santiago, Chile

Alejandro Arriagada

Coordinador y docente

Núcleo de Ciencias Biológicas

Universidad Mayor de Chile

Santiago, Chile

Mauricio Lozano

Asistente de Investigación

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

Andrés Tittarelli

Profesor Asociado

Instituto Universitario de Investigación y Desarrollo Tecnológico (IDT)

Universidad Tecnológica Metropolitana

Santiago, Chile

Alvaro Becerra

Profesor Asociado

Ciencias Químico y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Maria Opazo

Profesor Asociado

Universidad de Las Américas

Santiago, Chile

Gilberto González

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

JULIO TAPIA

Full Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Edio Maldonado

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

María Gleisner

INVESTIGADORA

ICBM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

ALEJANDRA TAPIA

Investigador

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

Pedro Ayala

Profesor investigador asistente

Departamento de Enfermedades Respiratorias

Pontificia Universidad Católica de Chile

Santiago, Chile

Solange Rivas

Postdoctoral Research Assistant

Oncología básico-clínico

Universidad de Chile

Santiago, Chile

Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Carlos Romero

Medico Intensivista

Medicina

Hospital Clinico Universidad de Chile

Santiago, Chile

Pablo González

Associate Professor

Molecular Genetics and MIcrobiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Ivan Ruminot

INVESTIGADOR

BIOLOGIA

CENTRO DE ESTUDIOS CIENTIFICOS

VALDIVIA, Chile

Andres Herrada

Principal Investigator

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Talca, Chile

Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

Francisco Valenzuela

Academico

Ciencias Básicas

UNIVERSIDAD DEL BÍO BÍO

Chillan, Chile

Ariel Caviedes

Postdoctorado

Escuela de psicología

Universidad Adolfo Ibánez

Santiago, Chile

Cristobal Alvarado

Jefe Unidad de Apoyo a la Investigación Biomédica.

Hospital Las Higueras de Talcahuano

Talcahuano, Chile

Andrés González

Staff Scientist

Neurociencias

Instituto de Neurociencia Biomédica

Santiago, Chile

Natacha Marini

Floria Pancetti

Director de Departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

Rodrigo Sandoval

Director de departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

Gabriel Cavada

Académico, Jefe de Programa

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

GLORIA TORRES

Investigadora Postdoctoral

CIIB

Universidad de Los Andes

Santiago, Chile

Carmen Romero

Jefe Laboratorio Endocrinología y Biología Reproductiva

Obstetricia y Ginecología

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile

RAMON SERRA

JEFE DE SERVICIO

GINECOLOGIA

HOSPITAL NAVAL FFAA

PUNTA ARENAS, Chile

Daniel Moena

Docente

Química y Medio Ambiente

Universidad Técnica Federico Santa María

Concepción, Chile

Luis Fernando Michea Acevedo

Líneas de Investigación

Educación

CIENCIAS BIOMEDICAS, UNIVERSIDAD DE CHILE. Chile, 1996

MD, UNIVERSIDAD DE CHILE. Chile, 1991

Filosofía, UNIVERSIDAD DE LOS ANDES. Chile, 2006

Experiencia Académica

PROFESOR ASISTENTE Full Time

DIRECTOR DE INVESTIGACION Y TECNOLOGIA Full Time

PROFESOR ASISTENTE Full Time

PROFESOR ASOCIADO Full Time

PROFESOR ASOCIADO Full Time

Experiencia Profesional

VISITING SCIENTIST Full Time

PROFESOR ASISTENTE Full Time

PROFESOR ASOCIADO Full Time

PROFESOR ASISTENTE Full Time

DIRECTOR DE INVESTIGACION Y TECNOLOGIA Full Time

PROFESOR ASOCIADO Full Time

Formación de Capital Humano

Premios y Distinciones

Young Research Investigator Award

Best Clinical Work Award

Research Investigator Award

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Best Research Work

Best Work Basic Sciences

Best Scientific Work

Best Basic Research

Best Basic Research

Best Basic Research

Young Investigator Award

Best Basic Research

Best Research Work

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Editorial Commentary

Invited Speaker

Letter to the Editor

Editorial Commentary

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Editorial Commentary

Latin American Scientist Award

Young Investigator Award

Best Research Work

The William E. Mitch, III, MD, FASN International Scholars

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Article (61)

Abstract (12)

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Proyecto (28)

Dietary chloride in the development of hypertension=> a new player regulating intrarenal renin-angiotensin system and dendritic cell activity?

REGULATION OF RENAL TUBULAR SODIUM REABSORPTION BY AMP-ACTIVATED PROTEIN KINASE ON ANGIOTENSIN II-INDUCED HYPERTENSION.

ROLE IN SODIUM HOMEOSTASIS AND HYPERTENSION OF A NOVEL MOLECULAR MECHANISM THAT MEDIATES THE ACTION OF ALDOSTERONE IN TARGET TISSUES=> REGULATION OF THE BETA-3 SUBUNIT OF THE SODIUM PUMP.

Instituto Milenio Inmunología e Inmunoterapia

THE INCRETIN GLUCAGON-LIKE PEPTIDE I=> STUDY OF NEW METABOLIC MECHANISMS IN VASCULAR REMODELING

ANGIOTENSIN-(1-9)=> A NEW PEPTIDE REGULATOR OF BLOOD PRESSURE THAT DECREASES CARDIOVASCULAR REMODELING AND RENAL INJURY

Pro-inflammatory conditions increase the permeability of the cell membrane through pathways that offer new therapeutic targets for human diseases

MECANISMOS DE ARTERIOESCLEROSIS EN LA INSUFICIENCIA RENAL CRONICA=> REGULACION DE LOS TRANSPORTADORES DE FOSFATO Y TRANSDIFERENCIACION DEL MUSCULO LISO POR ALDOSTERONA Y LEPTINA

Millennium Nucleus on Immunology and Immunotherapy

Centro FONDAP, Centro Estudios Moleculares de la Célula

ESTADO INMUNOLOGICO PROINFLAMATORIO MEDIADO POR ALDOSTERONA. ESTUDIO CLINICO Y EXPERIMENTAL DE LA FUNCION INMUNE Y ENDOTELIAL EN EL DANO CARDIOVASCULAR INDUCIDO POR HIPERALDOSTERONEMIA

MECANISMOS DE CARDIOPROTECCION DE ANTAGONISTAS DE ALDOSTERONA Y SU ACCION EN EL DANO CARDIOVASCULAR DE LA IRC=>ESTUDIOS CLINICOS Y EXPERIMENTALES.

POTENCIAL PARTICIPACION DE VASOPRESINA EN EL DANO CARDIOVASCULAR INDUCIDO POR ALTA INGESTA DE SAL Y MINERALOCORTICOIDES.