Man

Javier Octavio Morales Montecinos

Profesor Asistente

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Materiales poliméricos nanoestructuradas como sistemas de entrega controlada y dirigida de fármacos biológicos (biomacromoléculas) y fármacos convencionales

Educación

  •  Pharmaceutics, UNIVERSITY OF TEXAS AT AUSTIN. Estados Unidos, 2012
  •  Farmacia, UNIVERSIDAD DE CHILE. Chile, 2006
  •  Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2008

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Ciencias Químicas y Farmacéuticas

    Santiago, Chile

    Enero 2013 - A la fecha

Experiencia Profesional

  •   Graduate research Assistant Full Time

    The University of Texas at Austin

    Austin, Estados Unidos

    Enero 2008 - Enero 2012

  •   Profesor Part Time

    Instituto Profesional de Chile

    Santiago, Chile

    Enero 2007 - Enero 2008

  •   Intern Full Time

    Evonik Rohm GmbH

    Darmstadt, Alemania

    Enero 2011 - Enero 2011

  •   Miembro del comité editorial Part Time

    Drug Development and Industrial Pharmacy

    New York, Estados Unidos

    Enero 2013 - A la fecha

  •   Miembro del comité editorial Part Time

    AAPS PharmSciTech

    New York, Estados Unidos

    Enero 2014 - A la fecha

  •   Associate Editor Part Time

    Drug Development and Industrial Pharmacy

    New York, Estados Unidos

    Enero 2018 - A la fecha

Formación de Capital Humano


Director de 2 investigadores postdoctorales, 9 tesis dirigidas de pregrado, 3 tesis dirigidas de magíster, 6 tesis dirigidas de doctorado, 12 cursos de postgrado, 6 Unidades de Investigación de postgrado, 5 Actividades de titulación de postgrado, 38 Cursos de pregrado, 15 Unidades de Investigación de pregrado, 22 Actividades de titulación de pregrado, 3 Cursos nuevos de pregrado, 1 Curso innovado de pregrado, 2 Curso nuevo de postgrado.


Difusión y Transferencia


Patentes y aplicaciones de patentes
1. J.O. Morales, M. Montenegro-Nicolini, F. Campano-Hantscheruk. Forma farmacéutica para administración bucal de dosis altamente controlada, liberación controlada y estable de biomacromolécula que comprende película polimérica como sustrato de impresión y una tinta de inyección impresa sobre dicha película polimérica que comprende nanoparticulas o suspensiones de nanopartículas con dicha biomacromolécula, y método de preparación. Application Number CL201600112, and PCT/CL2017/050001
2. J.T. McConville, J.O. Morales, Alistair Ross. Bioadhesive films for local and/or systemic delivery. US Application Number 14/897140 (Submitted: December 9, 2015)
3. J.T. McConville, J.O. Morales, Alistair Ross. Bioadhesive films for local and/or systemic delivery. Application Number WO2014065870 A1 (Published: May 1, 2014)
4. J.T. McConville, J.O. Morales, K. Fraivillig, A. Schiano, E. Vansant, L. Hansen. Polymer Strip for Treatment of Oral Thermal Burns. Application/Provisional Number 61/717,082 (Submitted: Oct 22, 2012).
5. J.T. McConville, J.O. Morales, K. Fraivillig, A. Schiano, E. Vansant, L. Hansen. Medicated Polymer Film Strip: Application/Provisional Number 61/719,922 (Submitted: Oct 29, 2012)


Premios y Distinciones

  •   Abstract Reviewer and Publication Coordinator for the Taylor and Francis Group and and ExcipientFest 2017

    Taylor and Francis Group

    Estados Unidos, 2017

    Selected to review and coordinate the publication in Drug Development and Industrial Pharmacy of the best abstracts at ExcipientFest 2017 in Providence, RI

  •   Poster Exposition 1st Prize for the Department of Pharmaceutical Science and Technology

    UNIVERSIDAD DE CHILE

    Chile, 2017

    Poster Exposition 1st Prize for the Department of Pharmaceutical Science and Technology for: Desarrollo de quantum dots de óxido de zinc como nanocarriers de curcumina sensibles al pH tumoral

  •   BPS–USP PSWC2017 Congress Travel Scholarship

    BPS–USP PSWC2017 Congress

    Suecia, 2017

    Recipient of a Congress Scholarship based on academic excellence as a Young researcher/professor. Funding to attend and present at the FIP 6th Pharmaceutical Sciences World Congress 2017 in Stockholm, Sweden

  •   2015 ASILFA Distinguished Professional

    ASILFA

    Chile, 2016

    Recipient of the Distinguished Professional Award from the Industrial Association of Pharmaceutical Companies (ASILFA from its Spanish translation) for outstanding work in Research & Development on Pharmaceutical Sciences. Santiago, Chile

  •   Invited to chair the Symposium on “Challenges and future prospects of alternative delivery of biologics”

    AAPS Annual Meeting and Exposition

    Estados Unidos, 2015

    Invited to chair the Symposium on “Challenges and future prospects of alternative delivery of biologics” and to speak on “Buccal drug delivery of biologics as an alternative delivery route” to be presented in Orlando, Florida, USA in October 2015

  •   Invited to chair the Symposium in “Macromolecule Drug Delivery: Challenges and Triumphs”

    AAPS National Biotechnology Conference

    Chile, 2014

    Invited to chair the Symposium in “Macromolecule Drug Delivery: Challenges and Triumphs” and to speak on “Buccal Delivery of Insulin Using Flexible Films” presented in San Diego, CA in May 2014


Tipos de Producción
 

Dtp Import/Article (24)

Buccal delivery of small molecules and biologics=> of mucoadhesive polymers, films, and nanoparticles
Buccal dosage forms: General considerations for pediatric patients
Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films
Formulation and Delivery of Biologics
Inkjet printing of proteins: an experimental approach
Overview and future potential of buccal mucoadhesive films as drug delivery systems for biologics
Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer
Book Review of “Remington: Essentials of Pharmaceutics”
Nanoparticles for the treatment of wounds
Novel nanostructured polymeric carriers to enable drug delivery for cardiovascular diseases
Organic and inorganic nanoparticles for prevention and diagnosis of gastric cancer
Films loaded with Insulin-coated nanoparticles (ICNP) as potential platforms for peptide buccal delivery
Lipid Nanosystems for Skin Delivery of Retinoids and Derivatives
Novel strategies for the buccal delivery of macromolecules
Preface for Buccal Drug Delivery Special Edition
A design of experiments to optimize a new manufacturing process for high stability protein-containing submicron particles
Protein-coated nanoparticles embedded in films for buccal delivery
The influence of recrystallized caffeine on water-swellable polymethacrylate mucoadhesive buccal films
Manufacture and Characterization of Mucoadhesive Buccal Films
Surfactants: their critical role in enhancing drug delivery to the lungs
Orally Disintegrating Tablets Using Starch and Fructose
Characterization, phase solubility and molecular modeling of inclusion complex of 5 nitroindazole
Effect of surfactants and drug load on physico-mechanical and dissolution properties of nanocrystalline tadalafil-loaded oral films

Grant (20)

Advanced Center for Chronic Diseases (ACCDiS)
Ayuda de viaje
Beca Igualdad de Oportunidades
Centre for Research in Medical Devices (CÚRAM)

Article (19)

Development of Novel EE/Alginate Polyelectrolyte Complex Nanoparticles for Lysozyme Delivery: Physicochemical Properties and In Vitro Safety
A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages
Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches
The Effect of Inkjet Printing over Polymeric Films as Potential Buccal Biologics Delivery Systems
Buccal dosage forms: General considerations for pediatric patients
Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes
Effect of plasticizers on the physico-mechanical properties of pullulan based pharmaceutical oral films
Formulation and Delivery of Biologics
Inkjet Printing of Proteins: an Experimental Approach
Overview and future potential of buccal mucoadhesive films as drug delivery systems for biologics
Nanoparticles for the Treatment of Wounds
Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases
Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer
Films loaded with insulin-coated nanoparticles (ICNP) as potential platforms for peptide buccal delivery
A design of experiments to optimize a new manufacturing process for high stability protein-containing submicron particles
Protein-coated nanoparticles embedded in films as delivery platforms
The Influence of Recrystallized Caffeine on Water-Swellable Polymethacrylate Mucoadhesive Buccal Films
Manufacture and Characterization of Mucoadhesive Buccal Films
Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins

Patent (4)

Bioadhesive films for local and/or systemic delivery
Polymer Strip for Treatment of Oral Thermal Burns

Book Section (4)

Buccal delivery of nanoparticles
Mechanical Particle Size Reduction Techniques
Drug Delivery Systems: Oral Mucosal
Surface-modified nanoparticles to improve drug delivery

Review (3)

Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer
Lipid nanoparticles for the topical delivery of retinoids and derivatives
Novel strategies for the buccal delivery of macromolecules

Editorial Material (2)

Selected abstracts from Excipient Fest 2017
Preface for buccal drug delivery theme issue
52
Javier Morales Montecinos

Profesor Asistente

Departamento de Ciencias y Tecnología Farmacéuticas

Universidad de Chile

Santiago, Chile

3
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Ignacio Moreno

INST. CIENCIAS QUÍMICAS, FAC. CIENCIAS, UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Karina Valdés

Asistente

Ciencias y Tecnología Farmacéutica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Patricio Reyes

JEFATURA DE SECCIÓN

ANAMED

INSTITUTO DE SALUD PÚBLICA DE CHILE

SANTIAGO, Chile

1
Francisco Morales

Posdoctoral

Universidad de Chile. Centro FONDAP ACCDiS

Santiago, Chile

1
Natalia Hassan

Académico

Universidad Tecnológica Metropolitana

Santiago, Chile

1
Eyleen Araya

Academic

Chemical Sciences

Universidad Andres Bello

santiago, Chile

1
Miguel Jara

Asistente de Investigación

de Ciencias y Tecnología Farmacéuticas

Universidad de Chile

Santiago , Chile

1
Andronico Neira

Titular Professor

Biological and Animal Science

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Soledad Bollo

PROFESOR TITULAR

QUIMICA FARMACOLÓGICA Y TOXICOLÓGICA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Javier Morales

Académico - Profesor Asociado

Ciencias y Tecnología Farmacéuticas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Gerald Zapata

DEPARTAMENTO DE QUÍMICA INORGÁNICA Y ANALÍTICA FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS UNIVERSIDAD DE CHILE

Santiago, Chile

1
Claudio Olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Carolina Jullian

Profesor Asociado

Quimica Organica y Fisicoquimica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile