1505760_40619902032258

Juan Carlos Roa Strauch

Chair

Pontificia Universidad Catolica de Chile

SAntiago, Chile

Líneas de Investigación


Biobank national network in Chile; Translational research in digestive tumor, with special emphasys in gallbladder cancer; Research on HPV and its role in cervix preneoplastic and neoplastic lesions.

Educación

  •  Medical Doctor, UNIVERSIDAD DE LA FRONTERA. Chile, 1991
  •  Oncologia molecular, Centro de estudios sanitarios de Europa. España, 2012
  •  Especialista en Anatomia patologica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1995
  •  Fellowship in molecular biology, LOUISIANA STATE UNIVERSITY. Estados Unidos, 1999

Experiencia Académica

  •   Assistant Professor Part Time

    UNIVERSIDAD DE LA FRONTERA

    Medicine

    Temuco, Chile

    Enero 1995 - Enero 2004

  •   Associate Professor Part Time

    UNIVERSIDAD DE LA FRONTERA

    Medicine

    Temuco, Chile

    Enero 2004 - Enero 2009

  •   Full Professor Full Time

    UNIVERSIDAD DE LA FRONTERA

    Medicine

    Temuco, Chile

    Enero 2010 - Enero 2013

  •   Full professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    Enero 2012 - A la fecha

Experiencia Profesional

  •   Professor Part Time

    Universidad de la Frontera

    Temuco, Chile

    Enero 1995 - Enero 2013

  •   Surgical Pathologist Full Time

    Hospital Regional Temuco

    Temuco, Chile

    Enero 1995 - Enero 2012

  •   Surgical Pathologist Full Time

    Pontificia Universidad Catolica de Chile

    SAntiago, Chile

    Enero 2012 - A la fecha

Formación de Capital Humano


1.- Efecto de la modulación de la expresión de reprimo (RPRM) sobre el comportamiento tumoral en líneas celulares de cáncer de mama. Ph.D.c Kurt Buchegger. Molecular Biology PhD. Program. Universidad de la Frontera. 2011-in progress.
2.- Detección del Virus Papiloma Humano (HPV) en DNA transrenal como herramienta de diagnóstico temprano en Cáncer Cérvicouterino. Ph.D.c Ismael Riquelme. Molecular Biology PhD. Program. Universidad de la Frontera. 2011-in progress.
3.- Rol de miR-335 y miR-597 en la inactivación del gen Reprimo en cáncer gástrico. Ph.D.c Alejandra Sandoval. Molecular Biology PhD. Program. Universidad de la Frontera. 2011-in progress.
4.- Reprimo como potencial Gen Supresor de Tumores en Cáncer Gástrico. Ph.D.c Kathleen Saavedra. Molecular Biology PhD. Program. Universidad de la Frontera. 2011-in progress.
5.- Inactivation of ErbB3 expression due to miRNAs deregulation in cancer of the gallbladder and its effect on tumor behavior.
Jaime Patricio Lopez (Master in Sciences). Molecular Biology PhD. Program. Universidad de la Frontera. 2009-2012.
6.- Identification of Epigenomic Biomarkers of diagnosis and progression in Cervical Carcinogenesis. Ph.D. Priscilla Brebi. Molecular Biology PhD. Program. Universidad de la Frontera. 2008-2011.
7.- c-FLIP (celular FLICE-like inhibitory protein) characterization as diagnosis or prognosis biomarker in preneoplastic and neoplastic cervical lesions. Ph.D. Carmen Gloria Ili. Molecular Biology PhD. Program. Universidad de la Frontera. 2008-2011.
8.- Characterization of CTGF ( connective tissue growth factor) in GBC ant its effects in cellular invasión, tumoral behavior. Ph.D. Patricia Alejandra García Muñoz. Molecular Biology PhD. Program. Universidad de la Frontera. 2008-2011.
9.- Obtaining genic expression profiles from colon cancer by microarray technology. Ph.D Felipe Benavente Muñoz. Molecular Biology PhD. Program. Universidad de la Frontera. 2006-2010.
10.- Set up and use of Proteomics techniques in Gallbladder and gastric carcinogénesis Study. Postdoctoral Research. PhD. Fulgencio Espejel Carrasco. Postdoctorade PBCT- Academy Insertion. 2006-2009.
11.- Ubiquitine-ligase SCF complex FBW7 Protein expression , As potencial therapeutic target in gastric cancer. Postdoctoral Research. PhD. Pamela Alejandra Leal Rojas. Postdoctorade PBCT- Academy Insertion. 2006-2009.
12.- Patterns of promoter genic methylation in preneoplastic and neoplastic lesions of gallbladder. Patricia Alejandra García Muñoz (Master in Sciences). Molecular Biology PhD. Program. Universidad de la Frontera. 2005-2007.
13.- Perfil de metilación de genes supresores de tumores como factor pronóstico en pacientes con leucemia Mieloide Aguda. Soledad Reyes (Master in Sciences). Molecular Biology PhD. Program. Universidad de la Frontera. 2008-2010.
14.-Evaluación de los mecanismos moleculares de resistencia a la terapia fotodinámica in vitro y su potencial aplicación como marcadores en el tratamiento de lesiones preneoplásicas y neoplásicas de cáncer de piel no melanoma.Molecular Biology PhD. Program. Universidad de la Frontera. Daniela Leon 2013 In progress.
15Transcriptomic profiling of gallbladder cancer progression. Molecular Biology Conicyt Postdoctorado. Pontificia Universidad Catolica de Chile. 2013 In progress. Jaime Espinoza.
16.- “Identification and validation of prognostic biomarkers and potential therapeutic targets of the Hippo signaling pathway in gallbladder cancer patients. Conicyt Postdoctorado. Pontificia Universidad Catolica de ChileCarolina Bizama. 2013 In progress.


Difusión y Transferencia


Dr. Roa is a surgical and molecular Pathologist with extensive experience in biobanking and bioarchives, which are essential for the success of this project. Dr. Roa is one of the founder of the first biobank in Chile and is currently setting up the first biobank national network in Chile. He already has organized a Bioarchive in 2 different institutions and he is currently in-charge of the facilities dedicated to make tissue microarrays (TMA) blocks from different tumors. He has a completely characterized breast cancer cohort (clinical data and followup) and has currently recruited 1,000 patients with this disease. His molecular pathology lab is devoted to the identification and validation of biomarkers in gastrointestinal (gallbladder and gastric) and gynecological (breast and cervix cancer) tumors focusing on genetic predisposition, early diagnosis, prognosis and target. He has been PI and Co-PI on several gallbladder, cervix uterine cancer grants funded by the CORFO and Fondecyt programs. He has published over 150 peer reviewed scientific papers and numerous book chapters in the field. He is director of the Molecular Pathology Laboratory and former Director of Postgraduate and Research at the School of Medicine at Universidad de La Frontera. Since 2012, He is Director of the Department of Pathology at the Faculty of Medicine and PI of the Molecular Pathology Research Laboratory at Pontificia Universidad Católica de Chile and member of a study group on medicine for Fondecyt Program and a member of the academic committee of the Molecular Biology and the Medical Sciences doctoral programs.

Patents (as coinventor)
1. Novel Genes and uses thereof, expression profile of colon, gastric and pancreatic 61/404,141 ( USA) 2011.
2.-“HPV easy typing” Número de tramitación 765-2012 (INAPI) via PCT


Premios y Distinciones

  •   Scientific Productivity Award

    UNIVERSIDAD DE LA FRONTERA

    Chile, 2011

    Scientific Productivity Award. 2002-2011

  •   Chilean Gastroenterology Congress Award

    SOCIEDAD CHILENA DE GASTROENTEROLOGIA

    Chile, 2003

    Best Presentation Award 2001-2003

  •   Chilean Academy of Medicine Award

    ACADEMIA CHILENA DE MEDICINA

    Chile, 2001

    Chilean Academy of Medicine Award, collaborator.

  •   Scientific Productivity Award

    UNIVERSIDAD DE LA FRONTERA

    Chile, 2001

    Best Scientific Productivity 1997-2001

  •   Gonzalo Tolosa Award

    Gonzalo Tolosa Award

    Chile, 1991

    The best medicine graduate student

  •   Cautin Medical Society Award

    Cautin Medical Society Award

    Chile, 1989

    For Investigative Pathology


Tipos de Producción
 

Journal Article (209)

High intraspecific variability of Echinococcus granulosus sensu stricto in Chile
Poorly cohesive cell (diffuse-infiltrative/signet ring cell) carcinomas of the gallbladder: clinicopathological analysis of 24 cases identified in 628 gallbladder carcinomas
Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer
The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer
TNFα-Induced Mucin 4 Expression Elicits Trastuzumab Resistance in HER2-Positive Breast Cancer
Association of inflammatory and other immune markers with gallbladder cancer: Results from two independent case-control studies
Circulating MicroRNAs as Biomarkers in Biliary Tract Cancers
Immunohistochemical expression of RPRM is associated with low expression of proliferation marker Ki67 in patients with breast cancer
Low expression of equilibrative nucleoside transporter 1 is associated with poor prognosis in chemotherapy-naïve pT2 gallbladder adenocarcinoma patients
miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway
MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1
Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Other Tumoral Intraepithelial Neoplasms of Pancreatobiliary Tract Recommendations of Verona Consensus Meeting
RNA sequencing-based analysis of gallbladder cancer reveals the importance of the liver X receptor and lipid metabolism in gallbladder cancer
Salmonella enterica serovar Typhi and gallbladder cancer: a case-control study and meta-analysis
Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression, PDCD4 downregulation and breast cancer metastasis
Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014-2024
The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines
Beneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis
Calcium calmodulin dependent kinase kinase 2-a novel therapeutic target for gastric adenocarcinoma
Effects of c-FLIPL knockdown in cervical uterine carcinoma cell lines [Efectos de la inhibición de C-Flipl en líneas celulares de Cáncer de cuello uterino]
Endoscopic submucosal dissection in early gastric cancer. Experience in 16 patients
Gallbladder Cancer: expert consensus statement
Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer
Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways
Heregulin Co-opts PR Transcriptional Action Via Stat3 Role As a Coregulator to Drive Cancer Growth
Long non-coding RNAs in gastric cancer: mechanisms and potential applications
Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer
Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy
Quantitative phosphoproteomic analysis of IL-33-mediated signaling
Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice
Tumor Location Is a Strong Predictor of Tumor Progression and Survival in T2 Gallbladder Cancer An International Multicenter Study
COMPLETE PATHOLOGICAL RESPONSE TO IMATINIB MESYLATE IN AN EXTRAINTESTINAL GASTROINTESTINAL STROMAL TUMOR
EFFECTS OF c-FLIPL KNOCKDOWN IN CERVICAL UTERINE CARCINOMA CELL LINES
Estimation of thyroid cancer incidence in Chile based on pathological reports
Evaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer: exploratory study phase I
Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population
Genotyping of human papillomavirus in women under 25 years old treated in the screening program for cervical cancer
Human Papilloma Virus Frequency in non-Gynecological Tumors in the Araucania Region, Chile
Human papilloma virus frequency in non-gynecological tumors in the araucanía region, Chile [Frecuencia de virus papiloma humano en tumores no ginecológicos de la región de la araucanía, Chile]
Hypermethylation of Tumor Suppressor Gene p53 in Chilean Pediatrics Patients Under 15 Years with Acute Lymphoblastic Leukemia
IDENTIFICATION OF PROSAPOSIN AND TRANSGELIN AS POTENTIAL BIOMARKERS FOR GALLBLADDER CANCER USING QUANTITATIVE PROTEOMICS
IMMUNOHISTOCHEMICAL ANALYSIS OF THE PI3K/AKT/mTOR PATHWAY IN GASTRIC CANCER: CORRELATION WITH CLINICOPATHOLOGICAL FEATURES AND CUMULATIVE SURVIVAL.
IMMUNOHISTOCHEMICAL EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR A INADVANCED GALLBLADDER CARCINOMA
MIR-1 AND MIR-145 ACT AS TUMOR SUPPRESSOR MICRORNAS IN GALLBLADDER CANCER
SYNCHRONOUS ILEOCECALAND DUODENAL TUBERCULOSIS: CASE REPORT AND REVIEW OF THE LITERATURE
TARGETING ERBB-2 NUCLEAR LOCALIZATION AND FUNCTION INHIBITS BREAST CANCER GROWTH AND OVERCOMES TRASTUZUMAB RESISTANCE
TUMOR LOCATION IS A STRONG PREDICTOR OF TUMOR PROGRESSION AND SURVIVAL IN T2 GALLBLADDER CANCER: AN INTERNATIONAL MULTICENTER STUDY
AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines
Cellular FLICE-like Inhibitory Protein Long Form (c-FLIPL) Overexpression is Related to Cervical Cancer Progression
CMS: A Web-Based System for Visualization and Analysis of Genome-Wide Methylation Data of Human Cancers
Connective Tissue Growth Factor Immunohistochemical Expression Is Associated With Gallbladder Cancer Progression
Detection of human papilloma virus infection in men
Detection of Hypermethylation in Tumor Suppressor Genes APAF1, ASSP1, p73 and FHIT in Childhood Acute Lymphoblastic Leukemia
Early gallbladder carcinoma has a favorable outcome but Rokitansky-Aschoff sinus involvement is an adverse prognostic factor
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas
Frequency of Chlamydia trachomatis infection in a group of women from Region of Araucania, Chile
Immunohistochemical Expression of Phospho-mTOR Is Associated With Poor Prognosis in Patients With Gallbladder Adenocarcinoma
Inhibition of connective tissue growth factor (CTGF/CCN2) in gallbladder cancer cells leads to decreased growth in vitro
Neoadjuvant chemoradiation therapy for borderline pancreatic adenocarcinoma: report of two cases
Perfil de Metilación de Genes Supresores de Tumores APAF1, ASSP1, p73 y FHIT en Pacientes con Leucemia Linfoblástica Aguda Infantil
PROGESTERONE RECEPTOR ASSEMBLY OF A TRANSCRIPTIONAL COMPLEX ALONG WITH AP-1, STAT3 AND ERBB-2 GOVERNS BREAST CANCER GROWTH AND PREDICTS RESPONSE TO ENDOCRINE THERAPY
SILAC-based quantitative proteomic analysis of gastric cancer secretome
Treatment of the residual cavity during hepatic hydatidosis surgery: a cohort study of capitonnage vs. omentoplasty
VIRULENCE OF INFECTING HELICOBACTER PYLORI STRAINS AND AMOUNT OF MONONUCLEAR CELL INFILTRATION ARE ASSOCIATED WITH LEVELS OF DNA HYPERMETHYLATION IN GASTRIC MUCOSAE
Clinical and public health research using methylated DNA immunoprecipitation (MeDIP) A comparison of commercially available kits to examine differential DNA methylation across the genome
Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer
DNA PROMOTER METHYLATION AS A DIAGNOSTIC AND THERAPEUTIC BIOMARKER IN GALLBLADDER CANCER
EPIGENETIC ALTERATIONS IN PRENEOPLASTIC AND NEOPLASTIC LESIONS OF UTERINE CERVIX
Intracholecystic Papillary-Tubular Neoplasms (ICPN) of the Gallbladder (Neoplastic Polyps, Adenomas, and Papillary Neoplasms That Are >= 1.0 cm) Clinicopathologic and Immunohistochemical Analysis of 123 Cases
Mucinous Carcinomas of the Gallbladder Clinicopathologic Analysis of 15 Cases Identified in 606 Carcinomas
Overexpression of kinesin associated protein 3 (KIFAP3) in breast cancer
Pathologic staging of pancreatic, ampullary, biliary, and gallbladder cancers: pitfalls and practical limitations of the current AJCC/UICC TNM staging system and opportunities for improvement
Carcinoma epidermoide oral y orofaríngeo: Estudio clínico-patológico
Compromiso ganglionar extracapsular en pacientes con cáncer gástrico: determinación del valor pronóstico
Cáncer gástrico sin compromiso ganglionar linfático (pN0): características demográfico-patológicas y factores pronósticos
Diverticular disease of the appendix in appendectomies
Factores asociados al pronóstico de pacientes operados por cáncer gástrico avanzado
Factores morfológicos asociados al pronóstico de pacientes operados por cáncer gástrico incipiente
Gene Expression Profiling of Gastric Cancer
Genotyping of Human Papillomavirus in Cervical Intraepithelial Neoplasia in a High-Risk Population
Hyalinizing Cholecystitis and Associated Carcinomas: Clinicopathologic Analysis of a Distinctive Variant of Cholecystitis With Porcelain-like Features and Accompanying Diagnostically Challenging Carcinomas
Los Pericitos: Nuevos Enfoques en la Terapia Regenerativa, Patología Cerebrovascular y Cáncer
Oral and oropharingeal squamous cells carcinoma. Clinico-pathological study
Pathological features associated with survival in early gastric cancer
Pericytes: New Approaches in Regenerative Therapy, Cerebrovascular Pathology and Cancer
Prevalencia de enfermedad diverticular del apéndice cecal en pacientes apendicectomizados por apendicitis aguda
Prognostic factors for gastric cancer without lymph node involvement
Prognostic value of extracapsular lymph node involvement among patients with gastric cancer
Puntaje de Gleason en cáncer de próstata: Correlación de la biopsia por punción y prostatectomía radical
Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas
Tumores del Estroma Gastrointestinal (GIST): Características Clinico-Morfológicas y Perfil Inmunohistoquímico
Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis
Bone hydatidosis. Report of five patients
Breast hydatidosis. Report of one case
Carcinoma de células en anillo de sello gástrico: Descripción clínico-morfológica y valor pronóstico
Changes in morphological an clinical characteristics of gastric cancer from 1986 to 2005
Colon and Rectum Cancer: Morphological and Clinical Description of 322 Cases
Cáncer de Colon y Recto: Descripción Morfológica y Clínica de 322 Casos
Cáncer gástrico en una región de Chile: Comparación de variables clínicas y morfológicas en dos períodos (1986-1995 y 1996-2005)
Descripción clínico-morfológica y factores pronósticos en carcinomas de apéndice cecal: Estudio de cohorte
Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino
Duodenal villous atrophy associated with Mycophenolate mofetil. Report of one case
Evaluación de factores histológicos pronósticos de sobrevida en melanoma maligno cutáneo, seguimiento de 13 años
Genotipificación del virus papiloma humano en mujeres con adenocarcinoma cervical de la Región de La Araucanía-Chile
Hallazgos morfológicos en casos fatales de síndrome cardiopulmonar por hantavirus: Estudio de 7 autopsias
Human papillomavirus genotyping in cervical adenocarcinoma in the Region of La Araucania-Chile
Human papillomavirus genotyping of cervical uterine preneoplastic lesions in a high risk area
Morphological findings in fatal cases of hantavirus cardiopulmonary syndrome. Report of 7 autopsies
Prognosis of signet ring cell carcinoma of the stomach
Prognostic factors for survival of malignant melanomas
Survival of a cohort of patients with Intermediate and advanced gall bladder cancer treated with a prospective therapeutic protocol
The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma
Concomitant presence of a gastric adenocarcinoma and gastrointestinal stromal tumor. Report of one case
Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile
Detection and genotyping of human papillomavirus in biopsies of uterine cervical adenocarcinoma
Diagnostic value of frozen section biopsy during surgery for breast lesions or neoplasms
Early Gallbladder Cancer: Is Further Treatment Necessary?
HPV genotyping from invasive cervical cancer in Chile
Promoter Methylation Profile in Preneoplastic and Neoplastic Gallbladder Lesions
Description of Echinococcus granulosus genotypes in human hydatidosis in a region of southern Chile
Estudio de patrones de metilación génica en tumores del tubo digestivo
Gene methylation patterns in digestive tumors
Papillary carcinoma in a thyroglossal duct cyst. Report of two cases
Prevalence of human papillomavirus genital infection among male university students
Prevalencia de la infección genital por virus papiloma humano en hombres universitarios voluntarios de la IX Región, Chile
Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer
Detección y tipificación de virus papiloma humano en lesiones preneoplásicas del cuello uterino mediante PCR-RFLP
Detection and typification of human papilloma virus in pre cancerous cervical lesions
Hepatocarcinoma with sarcomatoid transformation. Case report
Hepatocarcinoma with sarcomatoid transformation. Case report Hepatocarcinoma con componente sarcomatoide. Caso clínico
Inestabilidad microsatelital en lesiones preneoplásicas y neoplásicas del cuello uterino: Correlación con el genotipo del virus papiloma humano
Microsatellite instability and human papilloma virus genotypes in preneoplastic and neoplastic uterine cervix lesions
Chemoradiotherapy in gallbladder cancer
Expresión inmunohistoquímica del complejo E-caderina-catenina en cáncer gástrico: Relación con variables clínico-morfológicas y sobrevida de pacientes
Frecuencia de los genes de fusión TEL/AML1 y BCR/ABL en pacientes pediátricos con leucemia linfoblástica aguda
Frequency of TEL/AML1 and BCR/ABL fusion genes in children with acute lymphoblastic leukemia
Gallbladder cancer: An analysis of a series of 139 patients with invasion restricted to the subserosal layer
Gallstones and gallbladder cancer-volume and weight of gallstones are associated with gallbladder cancer: A case-control study
Immunohistochemical expression of the E-cadherin-catenin complex in gastric cancer
Malignant melanoma in Chile: an unusual distribution of primary sites in men from low socioeconomic strata
Preneoplastic lesions in gallbladder cancer
Prognostic factors of phyllodes tumor of the breast
Promoter methylation profile in gallbladder cancer
Aneurysmal bone cyst of the maxilla. Report of one case
Detection of human papilloma virus in cytologic samples or biopsies of the cervix
Estudio del patrón de metilación génico en el cáncer gástrico en Chile
Frequency of K-ras mutation in biliary and pancreatic tumors
Microsatellite instability in preneoplastic and neoplastic lesions of the gallbladder
Mutación del gen K-ras en tumores pancreático-biliares
Promoter methylation profile in gastric cancer
Quiste aneurismático del maxilar superior: Reporte de un caso
Association between Helicobacter pylori genotype and the severity of gastritis in infected adults
Clinicopathological features of gallbladder polyps and adenomas
Detection of bone marrow micrometastases in patients with gallbladder cancer
DNA content and survival in subserous gallbladder carcinoma
Inactivación del gen CDKN2A (p16) en cáncer de la vesícula biliar
K-ras gene mutation in gallbladder carcinoma
Management of gallbladder cancer with invasion of the muscular layer
Neoadjuvant chemoradiotherapy in gallbladder cancer
Patrón de metilación génico en el cáncer de mama
Promoter methylation profile in breast cancer
Pólipos y adenomas de la vesícula biliar: consideraciones clínico-patológicas
Quimiorradioterapia de neoadyuvancia en cáncer de vesícula biliar
Relación de la genotipificación de Helicobacter pylori con la forma e intensidad de la gastritis en población adulta portadora de patología gástrica benigna
Hipofosfatemia revertida al extirpar hemangioendotelioma compuesto del dedo mayor del pie
Hipotiroidismo primario luego de la resección de un Struma ovarii: Report of one case
Human papilloma virus (HPV) typing in preneoplastic and neoplastic lesions of the uterine cervix in the IX region-Chile
Hypothyroidism after the excision of a Struma ovarii. Report of one case
Inestabilidad microsatelital y pérdida de la heterocigocidad en lesiones neoplásicas y preneoplásicas gástricas
Microsatellite instability and allelic imbalance in neoplastic and preneoplastic gastric lesions
Microsatellite instability and loss of heterozygosity in chronic gastritis
Mutación puntual del gen supresor de tumores TP53 en lesiones preneoplásicas y neoplásicas del estómago: cross- sectional study in a high risk region
Mutations of TP53 suppressor gene in pre-neoplastic and neoplastic lesions of the stomach: cross-sectional study in a high risk region
Tipificación del virus papiloma humano (VPH) en lesiones preneoplásicas y carcinoma del cuello uterino en mujeres de la IX Región-Chile
TRANSCRIPTOS DE FUSIÓN DEL GEN BCR/ABL EN PACIENTES CON LEUCEMIA MIELOIDE CRÓNICA
Detección de secuencias del gen BCR-ABL mediante RT-PCR en pacientes con leucemia en la IX Región: Chile
Detection of BCR-ABL gene sequences using polymerase chain reaction-reverse transcriptase in patients with leukemia
Elementos morfológicos pronósticos en el cáncer de la vesícula biliar
Expression of cadherine-catenine complex in subserous gallbladder carcinoma
Is gallbladder cancer a tumor with bad prognosis?
Morphological prognostic factors in gallbladder cancer
¿Es el cáncer de la vesícula biliar una enfermedad de mal pronóstico en Chile?
CD44 (HCAM) expression in subserous gallbladder carcinoma
Clinical and pathological features of early gallbladder carcinoma
Pathological findings in surgical reinterventions for gallbladder cancer in patients with and without preoperative chemo and radiotherapy
Gastric cancer and tumor growth regulation. Study of cell proliferation markers and protein complex p53/p21(WAF1/CIP1)/mdm-2
Microsatellite instability, prognosis and metastasis in gastric cancers from a low-risk population
p53 gene mutation in colorectal carcinoma
P53 Gene mutation in gallbladder cancer
Peritoneal pseudomyxoma in a child with a gallbladder Peutz-Jeghers- like hamartomatous polyp: A case report
DNA ploidy pattern and tumor suppressor gene p53 expression in gallbladder carcinoma
Double immunostaining for p53 and molecular chaperone hsp72/73 in gastric carcinoma
p53 tumour suppressor gene protein expression in early and advanced gallbladder carcinoma
Preneoplastic lesions and gallbladder cancer: An estimate of the period required for progression
Alteraciones genéticas en gastritis crónica: Estudio de inestabilidad microsatelital y pérdida de la heterocigocidad
Carcinoma incipiente de la vesícula biliar: Estudio clínico-patológico y pronóstico de 196 casos
Carcinoma subseroso de la vesícula biliar: expresión del complejo caderina-catenina
Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar
Cáncer de la vesícula biliar: Manejo de pacientes con invasión de la túnica muscular
Descripción de genotipos de Echinococcus granulosus obtenidos de especímenes de hidatidosis humana
Detección de micrometástasis en médula ósea de pacientes con cáncer de vesícula biliar
Estudio comparativo de detección del virus papiloma humano (VPH) en muestras citológicas y biopsias de cuello uterino
Mutación del gen K-ras en el cáncer de la vesícula biliar

Generic (32)

Adenomatous (Dysplastic) Transformation in Cholesterol Polyps (CPs) of the Gallbladder (GB)
Cellular Phenotypes in Gallbladder Dysplasia: Diagnostic Significance and Clinical Associations in an Analysis of 318 Cases
Expression Analysis of AKT/mTOR Signaling Pathway in Primary Tumors and Cell Lines Derived from Gallbladder Cancer
Growth Patterns of High-Grade Gallbladder Dysplasia: Clinicopathologic Associations and Diagnostic Implications in an Analysis of 318 Cases
International Consensus Study on the Terminology and Diagnosis of Tumoral Intraepithelial Neoplasms ("Adenomas" and "Intracystic Papillary Neoplasms" of WHO-2010) of the Gallbladder
Is 1 cm a Valid Cut-Off as the Cholecystectomy Indication for Gallbladder Polyps?: Clinicopathologic Analysis of 432 Cases
Follicular Cholecystitis: Reappraisal of Incidence, Definition and Clinicopathologic Associations in an Analysis of 2413 Cholecystectomies
Gallbladder Pathology in IgG4-Related Sclerosing Disease
Heat Shock Protein (HSP)-90 Is Overexpressed in Gallbladder Carcinoma (GBC)
High Grade Dysplasia (Intraepithelial Neoplasia) of the Gallbladder (GB): Patterns, Cell Lineages and Clinicopathologic Associations in an Analysis of 255 Cases
Poorly Cohesive Cell (Diffuse-Infiltrative/Signet-Ring) Carcinomas of the Gallbladder (GB): Clinicopathologic Analysis of 24 Cases Identified in 628 GB Carcinomas
The Significance of Poorly Differentiated (Undifferentiated) Component in Gallbladder Carcinomas (GBC): Clinicopathologic Analysis of 54 Cases Identified in 628 GBC
Pathological factors associated with survival in advanced gastric cancer
Appendiceal malignant tumors. Review of 84 cases
Genetic alterations in preneoplastic and neoplastic injuries of the gallbladder
Intravesicular Papillary-Tubular Neoplasm (IVPN) as a Unifying Category for Mass-Forming Preinvasive Neoplasms of the Gallbladder: An Analysis of 87 Cases
Mucinous Carcinoma (MC) of the Gallbladder (GB): Clinicopathologic Analysis of 14 Cases Identified among 606 GB Carcinomas
Neuroendocrine Carcinomas of the Gallbladder: A Clinicopathologic Analysis of 23 Cases
Sclerocalcifying Cholecystitis (SclCC) and Associated Carcinomas: Characterization of a Clinicopathologically Distinct and Challenging Entity
Squamous Cell and Adenosquamous Carcinomas of the Gallbladder: Clinicopathologic Analysis of 34 Cases
Metaplasia in the Gallbladder: Populational Differences in the Incidence of Intestinal Metaplasia Supports Its Association with Carcinoma
Methylation profile as a prognostic factor in advanced gallbladder cancer
Local immune response and virulence factors of Helicobacter pylori infection in Chile
HFE gene mutations in Chile
HFE Gene Mutations in Chile [5] (multiple letters)
Regions of allelic imbalance on chromosome 12q in human gastric cancers.
Helicobacter pylori: cagA status and vacA genotyping in Chile. Detection of a s2/m1 strain
MOLECULAS DE ADHESION CELULAR Y CANCER
p53 tumor supresor gene in digestive cancer
Use of combined consensus human papillomavirus (HPV) DNA amplification for detection and identification of HPV in parafin-embedded cervical specimens

Abstract (20)

Epithelial Atypia in the Gallbladder: Diagnosis and Classification in an International Consensus Study
Marked Geographic Differences in the Pathologic Diagnosis of Non-Invasive (Tis) vs Minimally Invasive (T1) Gallbladder Cancer: Santiago Consensus Conference Highlights the Need for the Unifying Category "Early Gallbladder Cancer" (EGBC)
Not All T2 Gallbladder Carcinomas (GBC) Are Equal: Proposal for Sub- Staging of T2 GBC with Significant Prognostic Value
Not All T2 Gallbladder Carcinomas (GBC) Are Equal: Proposal for Sub-Staging of T2 GBC with Significant Prognostic Value
Prognosis of T2 Gallbladder Carcinomas: An Analysis of 326 Cases Highlights a Prognosis Better Than the Current Impression in the West, but Incomparably Worse Than What Is Reported in Asia
Adenomyomatous Nodules of the Gallbladder: Clinicopathologic Analysis of 234 Cases, Including 20 With Neoplastic Transformation
Clinicopathologic Analysis of 21 Deceptively Benign-Appearing Adenocarcinomas ("Adenoma Malignum") of the Gallbladder and Their Differential Diagnosis From Pseudoinfiltrative Processes
Comparative Genetic Analysis of Invasion-Resistant (Complex Non-Mucinous Pyloric) and Invasion-Prone Types of Intracholecytstic Papillary-Tubular Neoplasms of the Gallbladder
FIRST TRIMESTER MULTIPARAMETRIC MODEL FOR GESTATIONAL DIABETES PREDICTION
Gallbladder Carcinomas With Sarcomatoid Component: Clinicopathologic Analysis of 11 Cases
HSP90 Expression and Antitumoral Activity of Geldanamicin and Its Analog in Gallbladder Carcinoma
Pathologic Diagnosis as the Reason for Wide Discrepancies in the Literature Regarding the Incidence and Behavior of T1 Gallbladder Cancer (GBC): An Analysis of 473 GBC and Comparison With Literature
Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas: Recommendations of Verona Consensus Meeting
Stat3 and ErbB-2 interaction in breast cancer metastasis
Biologic Behavior of Gallbladder High-Grade Dysplasia: A Long-Term Survival Analysis of 125 Cases Elucidates a Mostly Curable Disease, Which Is a Marker of Biliary Tract Cancer Risk in Some Patients
Carcinoma In-Situ of the Gallbladder: The SEER Database Perspective
Complex Tubular Type Intracholecystic Papillary Tubular Neoplasms (ICPN): Further Clinicopathologic and Molecular Characterization
Immunophenotypic Characteristics and Classification of Non-Tumoral (Flat) Gallbladder Dysplasia
mTOR/P70S6K signaling pathway as a potential target for advanced gallbladder cancer therapy
Second-line FOLFOX chemotherapy in patients with metastatic gallbladder cancer and cholangiocarcinoma

Grant (12)

Genetic and Immunological Research Center.

Book Section (10)

Molecular Pathology of Gallbladder Cancer
Biología Molecular del Cáncer de Páncreas
Molecular Pathology of Neoplasms of Extrahepatic Bile Ducts
Neoplasms of the Gallbladder
Viral Cancers: Etiology, Pathogenesis and Treatment
Future Directions in Gastric Cancer Research
Methylation in Cancer Research
Preneoplastic Lesions of a Gallbladder from Morphological and Molecular Point of View
Specific Gene Methylation as a Gastrointestinal Tumor Marker
Consideraciones generales y genetico-moleculares del cáncer de los conductos biliares y de la vesícula biliar

Case Report (9)

Carcinosarcoma de la vesícula biliar: Caso clínico
Atrofia vellositaria duodenal inducida por micofenolato mofetil: Caso clínico
Hidatidosis de la mama: Reporte de un caso
Hidatidosis ósea: Reporte de 5 casos y revisión de la literatura
Adenocarcinoma gástrico primario concomitante con tumor estromal gastrointestinal: Reporte de un caso y revisión de literatura
ADENOCARCINOMA ENDOMETRIAL CONCOMITANTE CON TUMOR ESTROMAL BENIGNO DEL ENDOMETRIO
Carcinoma papilar en quiste del conducto tirogloso: Reporte de dos casos
Colitis quística profunda posradioterapia: Caso clínico
Hepatocarcinoma con componente sarcomatoide: Caso clínico

Review (7)

The inflammatory inception of gallbladder cancer
Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy
Intracholecystic papillary tubular neoplasm of the gallbladder with microinvasive carcinoma
Human papillomavirus infection in men and its relation with cancer: Current status and prospectics
Alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliar
Gallbladder cancer: a morphological and molecular update

Letter (2)

Synchronous ileocecal and duodenal tuberculosis: case report and review of the literature
Criteria for Pathologic Sampling of Gallbladder Specimens

Conference Poster (2)

Expression Analysis of AKT/mTOR Signaling Pathway in Primary Tumors and Cell Lines Derived from Gallbladder Cancer Authors
Level of miR-125B and miR-451 and Deregulated Expression of PI3K/AKT/mTOR Pathway in Gastric Cancer

Patent (2)

Novel genes and uses thereof, expression profile of colon, gastric and pancreatic cancer
Kit de deteccion y genotipificacion de HPV. “HPV easy typing”

Editorial Material (1)

Activated status of Hedgehog pathway in oral squamous cell carcinoma (OSCC): the door is still open

Errata (1)

Early gallbladder carcinoma has a favorable outcome but Rokitansky-Aschoff sinus involvement is an adverse prognostic factor (vol 463, pg 651, 2013)

Actualizacion (1)

Diagnóstico de la infección por virus papiloma humano en el hombre
335
Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

SAntiago, Chile

50
Juan Araya

Director

Anatomía Patológica

Hospital Dr. Hernan Henríquez Aravena

Temuco, Chile

21
Priscilla Brebi

Profesor Asociado

Departamento de Anatomía Patológica.

Universidad de La Frontera

Temuco, Chile

18
Carmen Ili

Investigador y Docente

Anatomía Patológica

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

17
Patricia Garcia

Profesor Asistente Adjunto

ANATOMIA PATOLOGICA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

10
Ismael Riquelme

Académico - Investigador

Ciencias de la Salud

UNIVERSIDAD AUTÓNOMA DE CHILE

Santiago, Chile

10
Sergio Muñoz

Director

Salud Publica

Universidad de La Frontera

Temuco, Chile

9
Carolina Bizama

Investigador Postdoctoral

Anatomía Patológica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

8
Carlos Manterola

Profesor Titular

Cirugía y Traumatología

Universidad de La Frontera

Temuco, Chile

8
Helga Weber

Investigador Post Doctoral Y Profesor colaborador

Vicerrectoría de Investigación y Post Grado

Universidad de la Frontera

Temuco, Chile

7
Jaime Lopez

Asistente de Investigación

Anatomía Patologica

Universidad de La Frontera

Temuco, Chile

6
Bruno Nervi

Associated Professor

Hematology - Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

5
Alejandra Andana

Asistente Investigación

Anatomía Patológica

Universidad de La Frontera

Temuco, Chile

5
Leonardo Anabalon

PROFESOR ADJUNTO

FAC RECURSOS NATURALES

UNIVERSIDAD CATOLICA DE TEMUCO

TEMUCO, Chile

4
Kurt Buchegger

Investigador Postdoctoral

Anatomía Patológica

Universidad de La Frontera

Temuco, Chile

3
Pablo Letelier

Docente Planta Permanente (Instructor)

UNIVERSIDAD CATOLICA DE TEMUCO

temuco, Chile

3
Nicolas Jarufe

Chief Digestive Surgery

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Alejandro Corvalan

Associate Professor

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Francisco Mucientes

Jefe de Sección

Especialidades

Universidad de Concepción

Concepción, Chile

2
Gonzalo De Toro

MEDICO ANATOMOPATOLOGO

HOSPITAL DE PUERTO MONTT - LABORATORIO DE ANATOMIA PATOLOGICA Y BIOLOGIA MOLECULAR

PUERTO MONTT, Chile

2
Juan Orellana

Asistente A

Salud Pública

Universidad de La Frontera

Temuco, Chile

1
Patricia Macanas

Profesor Asistente Adjunto

Hematology Oncology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

223543432, Chile

1
Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Laura Andrea Huidobro

Académico

Ciencias Preclínicas

Universidad Católica del Maule

Talca, Chile

1
Alvaro Passi

Coordinador técnico de proyectos de investigación

Salud Pública

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Ricardo Hartley

Académico

Universidad Central de Chile

Santiago, Chile

1
Rolando de la Cruz

Associate Professor

Institute of Statistics

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO, INSTITUTO DE ESTADÍSTICA

Valparaíso, Chile

1
Claudia Foerster

Académica

Instituto de Ciencias Agronómicas y Veterinarias

Universidad de O'Higgins

Rancagua, Chile

1
SANDRA CORTES

ASSISTANT PROFESSOR

PUBLIC HEALTH

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Claudia Bambs

Profesor asistente

Salud Publica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Marco Arrese

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Daniel Cabrera

Investigador Adjunto

Pontificia Universidad Catolica de Chile

santiago, Chile

1
Margarita Pizarro

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Francisco Aguayo

Profesor Asociado

Departamento de Oncología Básico Clínica

Universidad de Chile

Santiago, Chile

1
Fernando Romero

Profesor JC. Asociado

Ciencias Preclinicas

Universidad de La Frontera

Temuco, Chile

1
jorge Sapunar

Head of Unit

Internal Medicine

Universidad de La Frontera

Temuco, Chile

1
Jennie Risopatrón

Académico y Director del CEBIOR

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

1
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Daniela León

Alumna Tesista de Doctorado

Universidad de La Frontera

Temuco, Chile

1
Marcelo Kogan

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Jorge Farias

Associate Professor

Chemical Engineering

Universidad de La Frontera

Temuco, Chile

1
Raúl Sánchez

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Antonio Sanhueza

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Fernando Romero

Profesor JC, asociado

Ciencias Preclínicas

Universidad de La Frontera

Temuco, Chile

1
Ramón Silva

Docente

Universidad Autonoma

Temuco, Chile

1
Carmen Astete

Profesor titular

ICIM

Fac de Medicina. Universidad del Desarrollo

Santiago, Chile

1
Felipe Benavente

Investigador Postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jaime Madariaga

ASSOCIATE PROFESSOR

MEDICAL SPECIALTIES

UNIVERSITY OF CONCEPCION

CONCEPCION, Chile