Man

Alfredo Guillermo Criollo Cespedes

Assistant professor

Facultad de Odontología, Universidad de Chile

Santiago, Chile

Líneas de Investigación


-Autophagy -Cancer -Cell Death

Educación

  •  Biochemist, Universidad de Chile. Chile, 2004
  •  Ph.D. Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2009
  •  Ph.D. Molecular and Cellular Biology, Universidad de Paris. Francia, 2009

Experiencia Académica

  •   Assistant professor Full Time

    Fac de Odontología, Universidad de Chile

    Odontology

    Santiago, Chile

    Enero 2014 - A la fecha

Experiencia Profesional

  •   Post Doctoral Fellow Full Time

    UT Southwestern Medical Center

    Dallas, Estados Unidos

    Enero 2011 - Enero 2014

  •   Assistant professor Full Time

    Facultad de Odontología, Universidad de Chile

    Santiago, Chile

    Enero 2014 - A la fecha

Formación de Capital Humano


Patricio Silva: Post-Doctorate Fellow FONDECYT

Elisa Villalobos : Ph.D. Student, Programa Doctorado en Nutrición. Universidad de Chile
Daniel Peña : Ph.D. Student, Programa Doctorado en Bioquímica. Universidad de Chile
Pablo Rivera: Ph.D. Student, Programa Doctorado en Bioquímica. Universidad de Chile
Jimena Gatica: Ph.D. Student, Programa Doctorado en Nutrición. Universidad de Chile

Cecilia Hernando: Undergraduated Student. Universidad de Chile
Nadia Hernandez: Undergraduated Student. Universidad Iberoamericana de Ciencias y Tecnología
Sebastian Pino: Undergraduated Student. Universidad de Chile
Felipe Riquelme: Master Student. Universidad Nacional Andrés Bello
José Moreno: Undergraduated Student. Universidad de Chile


Difusión y Transferencia


2018 Organizer, International Workshop New Mechanisms of Autophagy in Chronic Diseases. Pontificia Universidad Católica de Chile. Santiago, Chile
2018 Autophagy in Stress, Development and Disease Gordon Research Conference. Lucca (Barga), Italy
2016 Organizer, ICGEB International Workshop. Autophagy: Physiological and Pathological Roles. Facultad de Odontología. Universidad de Chile.
2016 Organizer, Jornadas de Investigación y Expoinvestigacion de la Facultad de Odontología, Universidad de Chile.
2015 Organizer, Mesa redonda Autophagy: Expanding the Knowledge. Auditorium Abate Molina. Pontificia Universidad Católica de Chile.
2015 Organizer, International Simposium. Key Roles of Autophagy in Chronic Diseases.Puerto Varas. Chile.


Premios y Distinciones

  •   Ph.D. Fellowship CONICYT

    FONDECYT

    Chile, 2005

    Ph.D. Fellowship

  •   Ph.D. Fellowship Foundation pour la Recherché Médicale (FRM)

    Foundation pour la Recherché Médicale

    Francia, 2007

    Ph.D. Fellowship

  •   PhD Fellowship International Collaboration Program ECOS-CONICYT

    Conicyt

    Chile, 2005

    Ph.D. Fellowship International Collaboration Chile-France

  •   Medal Hermann Niemayer

    Sociedad Chilena de Bioquimica y Biologia Molecular

    Chile, 2007

    Best Ph.D student in Biological Sciences in Chile

  •   Grand Prix of the Chancellery of the Universities of Paris

    Chancellery of the Universities of Paris

    Francia, 2010

    Best Ph.D. thesis in Biomedical Sciences in the Paris Region


Tipos de Producción
 

Article (59)

Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
Impact of estrogens and estrogen receptor-alpha in brain lipid metabolism
Polycystin-2-dependent control of cardiomyocyte autophagy
Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72
Hyperosmotic stress stimulates autophagy via polycystin-2
New Roles of the Primary Cilium in Autophagy
Poly(GP) proteins: a potential pharmacodynamic marker in ALS and FTD
Sex Hormones and Cardiometabolic Health: Role of Estrogen and Estrogen Receptors
The effects of oestrogens and their receptors on cardiometabolic health
Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome AcidificationCLINICAL PERSPECTIVE
Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability
Organelle communication: Signaling crossroads between homeostasis and disease
Role of Heterotrimeric G Protein and Calcium in Cardiomyocyte Hypertrophy Induced by IGF-1
Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway
Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death
Autophagy is required for the activation of NFκB
Direct molecular interactions between Beclin 1 and the canonical NFκB activation pathway
Prognostic impact of vitamin B6 metabolism in lung cancer.
BH3 mimetics activate multiple pro-autophagic pathways
Illicit survival of cancer cells during polyploidization and depolyploidization
Inhibition of autophagy by TAB2 and TAB3
Longevity-relevant regulation of autophagy at the level of the acetylproteome
p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
Crosstalk between apoptosis and autophagy within the Beclin 1 interactome
miR-181a and miR-630 Regulate Cisplatin-Induced Cancer Cell Death
Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos
Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced hyperosmotic stress
The IKK complex contributes to the induction of autophagy
The life span-prolonging effect of sirtuin-1 is mediated by autophagy
Anti- and pro-tumor functions of autophagy
Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol
Control of autophagy by oncogenes and tumor suppressor genes
DRAM: a phylogenetically ancient regulator of autophagy
Induction of autophagy by spermidine promotes longevity
Stimulation of autophagy by the p53 target gene Sestrin2
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
Senescence, Apoptosis or Autophagy? When a Damaged Cell Must Decide Its Path
A dual role of p53 in the control of autophagy
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells
Methods for assessing autophagy and autophagic cell death
Mutant p53 protein localized in the cytoplasm inhibits autophagy
p53 represses autophagy in a cell cycle-dependent fashion
Reduction of endoplasmic reticulum Ca2+ levels favors plasma membrane surface exposure of calreticulin
Regulation of autophagy by cytoplasmic p53
Senescence, apoptosis or autophagy?
BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L)
Cell cycle-dependent induction of autophagy, mitophagy and reticulophagy
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
Mitochondrial control of cell death induced by hyperosmotic stress
Regulation of autophagy by the inositol trisphosphate receptor
The inositol trisphosphate receptor in the control of autophagy
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death
Hyperosmotic stress-dependent NF kappa B activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes
Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis - Differential effects of sorbitol and mannitol

Grant (6)

Advanced Center for Chronic Diseases (ACCDiS)
Polycystin2-Beclin-1: a novel protein complex in autophagy regulation

Dtp Import/Article (5)

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
An immunosurveillance mechanism controls cancer cell ploidy.
The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1
Chronic High Fat Diet Consumption Impairs Metabolic Health of Male Mice.
Regulation of cardiomyocyte autophagy by calcium

Review (3)

A sexually dimorphic hypothalamic response to chronic high-fat diet consumption
Tumor Suppression and Promotion by Autophagy
Cardiomyocyte death: mechanisms and translational implications

Book Section (2)

Autophagy networks in inflammation
Mutant p53 Located in the Cytoplasm Inhibits Autophagy

Editorial Material (1)

IKK connects autophagy to major stress pathways
76
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

20
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

16
Eugenia Morselli

Profesor Asistente de Planta Ordinaria

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

11
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

6
Eugenia Morselli

Assistant professor

Pontificia Universidad Católica

Santiago, Chile

6
Rodrigo Troncoso

Assistant professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

3
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

3
Mauricio Budini

Assistant Professor

Facultad de Odonotología

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

2
Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

1
Juan Santibáñez

Professor of Research

Molecular Oncology

Institute for Medical Research

Belgrade, Serbia

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
Roberto Bravo

Investigador Postdoctoral

Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile

Santiago, Chile

1
Steffen Hartel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Zully Pedrozo

Assistant professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

1
Claudio Olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Valentina Parra

Profesora Asistente / Assistant Professor

Departamento de Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile