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Rodrigo Hernán Troncoso Cotal

Assistant professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

Líneas de Investigación


Energetic metabolism regulation, obesity, physical exercise and glucocorticoid.

Educación

  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2009
  •  Pharmaceutical Chemist, UNIVERSIDAD DE CHILE. Chile

Experiencia Académica

  •   Assistant professor Full Time

    UNIVERSIDAD DE CHILE

    Instituto de Nutrición y Tecnología de los Alimentos

    Chile

    Enero 2014 - A la fecha

Experiencia Profesional

  •   Docente Part Time

    Universidad San Sebastián

    Chile

    Enero 2014 - Enero 2014

Formación de Capital Humano


2019
- Thesis for the degree of Master in Nutrition and Food, Mention Human Nutrition, INTA. Student: Omara Moya. "Sucralose as a disrupter of hepatic insulin sensitivity". Co-Director: Dr. Roberto Bravo. INTA, University of Chile. 2019-in development.

- Thesis for the degree of Master in Nutrition and Food, Mention Human Nutrition, INTA. Student: Pamela Pino. "Effect of intake of sucralose on mitochondrial function in a model of hepatic steatosis induced by a high-fat diet". Co-Director: Dr. Roberto Bravo. INTA, University of Chile. 2019-in development.

- Thesis for the degree of Master in Nutrition and Food, Mention Human Nutrition, INTA. Student: Stacy Bustos. "The induction of the stress response protein FKBP51 produces hepatic insulin resistance." INTA, University of Chile. 2019-in development.

- Thesis for the degree of Master in Nutrition and Food, Mention Human Nutrition, INTA. Student: Andrea Eunady. Co-Director: Dra. Valentina Parra. INTA, University of Chile. 2019-in development.

- Thesis for the degree of Master in Nutrition and Food, Mention Human Nutrition, INTA. Student: Angie Mountain. "Effect of sucralose on the regulation of autophagy in the mouse hepatocyte cell line AML12". Co-Director: Dr. Alfredo Criollo. INTA, University of Chile. 2019-in development.

- Thesis to apply for the degree of Master in Biochemistry, Faculty of Chemistry and Pharmacy. Student: Nicole Cancino. "Expression of myokines IL-6 and myostatin in mouse aorta during physical exercise". Co-Director: Dr. Mario Chiong. Faculty of Chemistry and Pharmacy, University of Chile. 2019-in development.

2018
- Thesis for the degree of Master in Nutrition and Food, Mention Human Nutrition, INTA. Student: Laura Quezada. "Effect of chronic physical exercise on the modulation of the hepatic endocannabinoid system in a model of hepatic steatosis due to a high-fat diet". Co-Director: Dr. Miguel Llanos. INTA, University of Chile. 2018-in development.

- Thesis for the degree of Master in Nutrition and Food, Mention Human Nutrition, INTA. Student: Edson Yañez. "Role of FKBP5 in a model of insulin desensitization induced by glucocorticoids". INTA, University of Chile. 2018-in development.

- Thesis for the degree of Master in Nutrition and Food, Mention Human Nutrition, INTA. Student: Juan Carlos Bórquez. "Effect of sucralose on mitochondrial oxidative function in the human enterocyte cell line Caco-2". Co-Director: Dr. Robero Bravo. INTA, University of Chile. 2018-2019.

- Thesis for the degree of Master in Nutrition and Food, Mention Human Nutrition, INTA. Student: Felipe Barahona. "Effect of sucralose consumption on longevity and intestinal autophagy in Drosophila melanogaster". Co-Director: Dr. Christian Hodar. INTA, University of Chile. 2018-in development.

2017
- Thesis to qualify for the degree of Master in Physiology, Faculty of Medicine. Student: Francisco Pino. "Role of chronic physical exercise in the regulation of lipophagy in a model of hepatic steatosis induced by a diet high in fat". Co-Director: Dr. Alejandra Espinosa. Faculty of Medicine, University of Chile. 2017- 2018.

- Thesis to qualify for the degree of Doctor in Nutrition and Food, INTA. Student: Carlos Sepúlveda. "Function of the endocannabinoid system in the regulation of autophagy in skeletal muscle". Co-Director: Dr. Miguel Llanos. INTA, University of Chile. 2017- in development.

- Thesis to qualify for the degree of Doctor in Nutrition and Food, INTA. Student: Matías Monsalves. "Effect of? -Hydroxybutyrate supplementation on skeletal muscle mitochondrial function". Co-Director: Dr. Sergio Lavandero. INTA, University of Chile. 2017- in development.

- Thesis to qualify for the degree of Doctor in Nutrition and Food, INTA. Student: Juan Rodriguez. "Role of Notch-1 in metabolic plasticity in cancer cells". Co-Director: Dr. Sandra Hirsch. INTA, University of Chile. 2017- in development.

2016
- Thesis to apply for the professional title of Biochemistry of the Pontifical Catholic University of Valparaiso. Student: Jonatan Dassonvalle. "Resistance to glucocorticoids in obesity: role of exercise in glucocorticoid sensitivity". INTA, University of Chile. 2016-2017.

- Thesis for the degree of Master in Nutrition and Food, Mention Human Nutrition, INTA. Student: Camila Donoso. "Physiological role of hydrogen sulfide in skeletal muscle and its relationship with insulin signaling". Co-Director: Dr. Omar Porras. INTA, University of Chile. 2016-2017.

- Thesis for the degree of Master in Nutrition and Food, Mention Human Nutrition, INTA. Student: Camila Fuentes. "Palmitate induces characteristics of cancer stem cells in the liver cancer cell line HepG2 through the activation of the Notch1 signaling pathway". Co-Director: Dr. Sandra Hirsch. INTA, University of Chile. 2016-2017.

- Thesis to qualify for the degree of Master in Nutrition and Food, Mention Clinical Nutrition, INTA. Student: Nicole Aguilera. "Autofagia in skeletal muscle tissue in subjects with visceral obesity subjected to an acute exercise session". Co-Director: Dr. María Pía de la Maza. INTA, University of Chile. 2016-2017.

- Thesis for the degree of Master in Nutrition and Food, Mention Human Nutrition, INTA. Student: Pamela Recabarren. "The regulation of the endocannabinoid system by glucocorticoids produces a differential regulation in the response to glucocorticoids in the cell line of skeletal muscle C2C12". Co-Director: Dr. Miguel Llanos. INTA, University of Chile. 2016-2017.

2015
- Thesis to apply for the degree of Master in Biotechnology, Andrés Bello University
Student: Claudia Sepúlveda. "Role of the Glucocorticoid Beta receptor in the metabolism of the HepG2 cell line" .INTA, Universidad de Chile. 2015-2017.

2014
- Thesis to apply for the professional title of Pharmaceutical Chemist, Pontificia Universidad Católica de Chile. Student: María Belén Farías. "Determine the role of the glucocorticoid receptor? in autophagy. " INTA, University of Chile. 2014-2016

- Thesis to apply for the professional title of Pharmaceutical Chemist, Pontificia Universidad Católica de Chile. Student: Izela Bernal Sore. "The drug RU486 increases insulin sensitivity through the modulation of the beta glucocorticoid receptor." INTA, University of Chile. 2014-2015

2012
- Thesis to apply for the Master's Degree in Biochemistry, University of Chile. Student: Alejandra Oyarzún. "The inhibitor of Nicotinamide Fosforribosiltransferasa, FK866, promotes desensitization to the insulin response in cardiomyocytes." Co-Director: Dr. Sergio Lavandero. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. 2012-2014.


Difusión y Transferencia


2019

- Column of Opinion "Healthy Eating and Cancer Prevention: Virtuous Alliance with a Long Way to Go, February 4, Digital Magazine Qué Pasa / La Tercera. https://www.latercera.com/canal/que-pasa/

- Column of Opinion "The Risk of Physical Inactivity: National Survey of Habits of Physical Activity and Sports". January 8, www.inta.cl

- Course "Childhood and adolescent obesity: epidemiology, physiopathology, diagnosis and therapeutic confrontation", 7-8 January, INTA.

2018

- Obesity: a permanent challenge. What is the science of our country doing to attack this phenomenon? October 30, MEDS Clinic.

- Obesity, Nutrition and Physical Activity. Conference on Education, Learning and Prevention of Chronic Diseases for Teachers. August 17, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

- Obesity, Nutrition and Physical Activity. Conference on Education, Learning and Prevention of Chronic Diseases for Students. August 24, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

- Obesity, Nutrition and Physical Activity. Science Week. August 10, English University College.
 
- Role of the skeletal muscle in the control of metabolism and insulin sensitivity. 1º Integral Seminar: "Plasticity of the Skeletal Muscle and Exercise". June 22, MEDS Clinic.

- Extension Course: Physical condition in school stage: A pending challenge, April 23, INTA, University of Chile.

2017
- The movement as an educational tool. Conference on Education, Learning and Prevention of Chronic Diseases for Teachers. October 20, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

- Physical Activity and Teamwork. Conference on Education, Learning and Prevention of Chronic Diseases for Students. October 13, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

2016
- "NUTRITION AND PHYSICAL ACTIVITY: THE PERFECT PARTNER TO LIVE HEALTHY". Conference for Teachers: Live Healthy: From Nutrition to Learning. December 16, Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

2015
- Interview Radio Cooperativa, Just Measure Program "Stress-Chronic Diseases".



Tipos de Producción
 

Article (31)

Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes
Hyperosmotic stress stimulates autophagy via polycystin-2
Irisin is weakly associated with usual physical activity in young overweight women
Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells
Atrial Function Assessed by Speckle Tracking Echocardiography Is a Good Predictor of Postoperative Atrial Fibrillation in Elderly Patients
Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity
HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor
Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival
FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes
Unsaturated fatty acids induce non-canonical autophagy
Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes
Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance
Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NF kappa B-Opa-1 Signaling Pathway
Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake
Organelle communication: Signaling crossroads between homeostasis and disease
Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death
Herp depletion protects from protein aggregation by up-regulating autophagy
Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol
Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy
Mitochondria, Myocardial Remodeling, and Cardiovascular Disease
Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress
Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes
Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide
Differential Participation of Angiotensin II Type 1 and 2 Receptors in the Regulation of Cardiac Cell Death Triggered by Angiotensin II
Gln(27)-> Glu beta(2)-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and Oxidative Response to Carvedilol
Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity
Hyperosmotic stress-dependent NF kappa B activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes
Effects of Carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure
Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress in patients with chronic heart failure

Review (7)

Glucocorticoid resistance in chronic diseases
New insights into IGF-1 signaling in the heart
Cardiovascular autophagy Concepts, controversies, and perspectives
Regulation of cardiac autophagy by insulin-like growth factor 1
Cardiomyocyte death: mechanisms and translational implications
Heart energy metabolism and its role in the treatment of heart failure
Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca

Grant (7)

Advanced Center for Chronic Diseases (ACCDiS)
Mechanisms of Autophagy in Obesity

Book Whole (2)

Autophagy in the Onset of Atrial Fibrillation
Regulation of autophagy by insulin/IGF-1 signaling pathways

Abstract (2)

Herp protects Hela cells from oxidative stress-induced cell death
Activity of metalloproteinase-9 is related to oxidative stress in the acute coronary syndrome

Journal Article (1)

Interacción entre los polimorfismos del receptor ß1 y ß2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica
50
Rodrigo Troncoso

Assistant professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

28
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

22
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

21
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

9
Hugo Verdejo

Profesor Asistente

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

7
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

6
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

6
Andrea del Campo

Posdoctorado

Laboratorio de FIsiología del músculo

Universidad de Chile

Santiago, Chile

5
Roberto Bravo

Investigador Postdoctoral

Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile

Santiago, Chile

4
Pablo Aránguiz

Postdoctorado

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

4
Rosemarie Mellado

Jefe de carrera / Académica

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Ramon Corbalan

Director

Division of Cardiovascular Diseases

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

3
Juan Carlos Quintana

Médico nuclear

Radiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Jorge Jalil

FULL PROFESSOR

ENFS CARDIOVASCULARES

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE MEDICINA

Santiago, Chile

2
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

2
Lorena Aguilar

Assistant Professor

Pathology

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

1
Ariel Castro

Associate Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

1
Dagoberto Soto

Investigador

Universidad Católica de Chile

santiago, Chile

1
Maria Molina

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

1
Roxana Pincheira

Profesor Asociado

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

1
Gina Sánchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

1
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Ismael Maldonado

Asistente de Investigación

Inmunología

Universidad de Chile

Santiago, Chile

1
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

1
Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

1
ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Claudio Olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Juan Santibáñez

Professor of Research

Molecular Oncology

Institute for Medical Research

Belgrade, Serbia

1
Mauricio Budini

Assistant Professor

Facultad de Odonotología

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Galia Ramirez

PROFESOR ASISTENTE

DEPARTAMENTO DE MEDICINA PREVENTIVA ANIMAL

UNIVERSIDAD DE CHILE - FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

1
Carolina Ribeiro

Assistant Professor

Immunology Program

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

1
Eugenia Morselli

Profesor Asistente de Planta Ordinaria

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

1
Teresa Jimenez

Nutricionista

INTA

Santiago, Chile

1
María Barrera

ACADEMICO

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE LOS ALIMENTOS

INTA. UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Omar Porras

Assistant professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Nicolas Tobar

Assistan Professor

Celullar Biology Laboratory

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS, INTA-UCHILE

Santiago, Chile

1
Mauricio Ibacache

Profesor Asociado

Pontificia Universidad Católica de Chile

santiago centro, Chile

1
Luigi Gabrielli

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile