Man

Juan Francisco Santibáñez Domínguez

Professor of Research

Institute for Medical Research

Belgrade, Serbia

Líneas de Investigación


Células madre mesenquimáticas; inflamación and Cancer

Educación

  •  Bioquimica, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 1990
  •  Doctorado en Ciencias Biológicas, UNIVERSIDAD AUTONOMA DE MADRID. España, 1999

Experiencia Académica

  •   Professor of Research Full Time

    Institute for Medical Reseach, University of Belgrade

    Belgrade, Serbia

    Enero 2008 - A la fecha

  •   Visiting professor Other

    UNIVERSIDAD BERNARDO O'HIGGINS

    Santiago, Chile

    Enero 2016 - A la fecha

Experiencia Profesional

  •   profesor asistente Full Time

    INTA, Universidad de Chile

    Santiago, Chile

    Enero 2000 - Enero 2008

  •   Instructor Full Time

    INTA, Universidad de Chile

    Santiago, Chile

    Enero 1996 - Enero 1999

  •   Profesor de Investigacion Full Time

    IMI, Universidad de Belgrado

    Serbia

    Enero 2008 - A la fecha

Premios y Distinciones

  •   Fundación Zanlungo

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Chile, 1989

    Estimulo académico

  •   Abraham Stekel program

    UNIVERSIDAD DE CHILE

    Chile, 1992

    Estimulo académico para Jovenes Investigadores

  •   Abraham Stekel program

    UNIVERSIDAD DE CHILE

    Chile, 1993

    Estimulo académico para Jovenes Investigadores

  •   Abraham Stekel program

    UNIVERSIDAD DE CHILE

    Chile, 1994

    Estimulo académico para Jovenes Investigadores

  •   Abraham Stekel program

    UNIVERSIDAD DE CHILE

    Chile, 1995

    Estimulo académico para Jovenes Investigadores

  •   Beca de doctorado

    Mutis (AECI/ICI)

    España, 1996

    Biological Doctoral program, Autonoma University /IIB Madrid, Spain

  •   Programa de doctores extranjeros en España

    Ministerio de Educación, Cultura y Deportes (MECD), Spain.

    España, 2003

    Estadia de instigacion en el Centro de Investigaciones Biológicas, CSIC. 18 meses

  •   7. Fonds de la Recherche Scientifique-FNRS

    Université Catholique de Louvain

    Bélgica, 2007

    Laboratory of Pharmacocinétique, Métabolisme, Nutrition e Toxicologie. Université Catholique de Louvain


 

Article (79)

Lipopolysaccharide Can Modify Differentiation and Immunomodulatory Potential of Periodontal Ligament Stem Cells via ERK1,2 Signaling
Obesity: An Emerging Importance of Progenitors
Oxidative Stress in Disease and Aging: Mechanisms and Therapies 2016
Correlation between telomere maintenance and stemness of mesenchymal stem/stromal cells
Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK1/2 Activation: Implications in Myogenic Differentiation
Inflammatory cytokines prime adipose tissue mesenchymal stem cells to enhance malignancy of MCF-7 breast cancer cells via transforming growth factor-β1
Mesenchymal Stem Cells from Different Tissues: Immune Status and Activity
TGF- Signalling and Its Role in Cancer Progression and Metastasis
The inhibition of periodontal ligament stem cells osteogenic differentiation by IL-17 is mediated via MAPKs
The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation
Transforming Growth Factor-Beta and Matrix Metalloproteinases Functional Interplay in Cancer; Implications in Epithelial to Mesenchymal Transition
An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling
Interleukin-17 and Its Implication in the Regulation of Differentiation and Function of Hematopoietic and Mesenchymal Stem Cells
Mesenchymal stem cells of different origin: Comparative evaluation of proliferative capacity, telomere length and pluripotency marker expression
Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression
Transforming growth factor-beta differently regulates urokinase type plasminogen activator and matrix metalloproteinase-9 expression in mouse macrophages; analysis of intracellular signal transduction
Urokinase type plasminogen activator mediates Interleukin-17-induced peripheral blood mesenchymal stem cell motility and transendothelial migration
Characteristics of human adipose mesenchymal stem cells isolated from healthy and cancer affected people and their interactions with human breast cancer cell line MCF-7 in vitro
Mesenchymal stem cells isolated from human periodontal ligament
Novel patents and cancer therapies for transforming growth factor-beta and urokinase type plasminogen activator: potential use of their interplay in tumorigenesis
Transforming Growth Factor-Beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-Infiltrating Myeloid Cells
GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells
In vitro effects of IL-17 on angiogenic properties of endothelial cells in relation to oxygen levels
Interleukin-17 modulates myoblast cell migration by inhibiting urokinase type plasminogen activator expression through p38 mitogen-activated protein kinase
Mesenchymal stem cells isolated from peripheral blood and umbilical cord Wharton’s jelly
Skip Regulates TGF- β 1-Induced Extracellular Matrix Degrading Proteases Expression in Human PC-3 Prostate Cancer Cells
Transforming Growth Factor-Beta and Urokinase-Type Plasminogen Activator: Dangerous Partners in Tumorigenesis—Implications in Skin Cancer
Effects of IL-17 on erythroid progenitors growth: involvement of MAPKs and GATA transcription factors
Interleukin 17 inhibits myogenic and promotes osteogenic differentiation of C2C12 myoblasts by activating ERK1,2
J Biol Regul Homeost Agents
SKIP Downregulation Increases TGF- β 1-Induced Matrix Metalloproteinase-9 Production in Transformed Keratinocytes
SMAD3 is essential for transforming growth factor-beta 1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes
Transforming growth factor-β superfamily, implications in development and differentiation of stem cells
Mesenchymal stem cell properties of dental pulp cells from deciduous teeth
IL-17 and FGF signaling involved in mouse mesenchymal stem cell proliferation
Synthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazines
TGF-β/TGF-β receptor system and its role in physiological and pathological conditions
Combined effect of IL-17 and blockade of nitric oxide biosynthesis on haematopoiesis in mice
New ruthenium(II) complexes with N-alkylphenothiazines: Synthesis, structure, in vivo activity as free radical scavengers and in vitro cytotoxicity
Rac1 modulates TGF-beta 1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes
ROS-NF kappa I' mediates TGF-beta 1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion
SKIP is required for TGF-beta 1-induced epithelial mesenchymal transition and migration in transformed keratinocytes
Spred2 inhibits TGF-beta 1-induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition
The Role of the TGF-β Coreceptor Endoglin in Cancer
The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras
Structural Antitumoral Activity Relationships of Synthetic Chalcones
RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NF kappa B-dependent mechanism
Caveolin-1 interacts and cooperates with the transforming growth factor-  type I receptor ALK1 in endothelial caveolae
Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling
Endoglin regulates cyclooxygenase-2 expression and activity
Hyperosmotic stress-dependent NF kappa B activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes
JNK mediates TGF-beta 1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes
Ha-Ras sensitizes transformed mouse skin cells to Anisomycin-induced apoptosis
Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-β receptor complex
Differential activation of ERK1,2 MAP kinase signaling pathway in mesenchymal stem cell from control and osteoporotic postmenopausal women
EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases
Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts. Possible modulation by genistein and curcumin
Cyclic AMP inhibits TGF beta 1-induced cell-scattering and invasiveness in murine-transformed keratinocytes
TGF-beta(1) and Smad4 overexpression induce a less invasive phenotype in highly invasive spindle carcinoma cells
Transforming growth factor-beta 1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes
ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS-2 cell line
Genistein and curcumin block TGF-? 1-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes
Genistein and curcumin block TGF-beta(1)-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes
Involvement of the Ras/MAPK signaling pathway in the modulation of urokinase production and cellular invasiveness by transforming growth factor-beta(1) in transformed keratinocytes
Bone extracellular matrix stimulates invasiveness of estrogen-responsive human mammary MCF-7 cells
Urokinase expression and binding activity associated with the transforming growth factor beta1-induced migratory and invasive phenotype of mouse epidermal keratinocytes
Effect of desialylated human chorionic gonadotropin (hCG) on the bioactivity of rat Leydig cells
Soluble factors secreted by PC-3 cells induce structural changes in proteoglycans produced by fetal rat osteoblasts
The compound 14-keto-stypodiol diacetate from the algae Stypopodium flabelliforme inhibits microtubules and cell proliferation in DU-145 human prostatic cells
Genistein inhibits proliferation and in vitro invasive potential of human prostatic cancer cell lines
Prostate-derived soluble factors block osteoblast differentiation in culture
Soluble factors produced by PC-3 prostate cells decrease collagen content and mineralisation rate in fetal rat osteoblasts in culture
The secretion of urokinase-like plasminogen activator is inhibited by microtubule-interacting drugs
Surface-associated plasminogen activation in leukemic cells: interaction with extracellular matrix
Extracellular calcium modulates proliferation of factor dependent hemopoietic cells
Membrane-associated procollagenase of leukemic cells is activated by urokinase-type plasminogen activator
The antineoplastic agent estramustine and the derivative estramustine-phosphate inhibit secretion of interleukin-3 in leukemic cells. Possible roles of MAPs
Binding and production of insulin-like growth factor-I in rat mammary gland
Insulin-like growth factor I receptor levels during the lactogenic cycle in rat mammary gland

Proyecto (9)

Determination of the mutational landscapes and clonal architecture and its application in angiogenesis and thrombosis of MPN patients
Regenerative and modulatory potential of mesenchymal stem cells
13. Cellular and molecular mechanisms involved in hematopoiesis regulation
TGF-beta1 Signal transduction regulation. Implications in tumor progression
TGF-beta Signal Transduction Pathways during tumor progression of mouse skin Carcinogenesis
Microambiente celular y molecular de la médula ósea generador de condiciones para sustentar los procesos hematopoiético, osteogénico y de progresión tumoral
Estudios de la función de proteínas asociadas a citoesqueleto en la invasión tumoral
Estudios de Invasión Tumoral
Signal transduction pathways in TGF- regulation of MMP-9 in mouse Skin Carcinogenesis

BookSection (5)

Novel Patents and Cancer Therapies for Transforming Growth Factor-β and Urokinase Type Plasminogen Activator: Potential Use of Their Interplay in Tumorigenesis
Janus kinase 2 and transforming growth factor beta signal transduction targeted therapies in myeloproliferative neoplasms
Transforming growth factor-beta regulation of urokinase type plasminogen system; mutual interactions and potential combinatory implications in oncotherapies
TGF-B and MMPs: A Complex Regulatory Loop Involved in Tumor Progression
INTERLEUKIN-17 RECEPTOR-A

Abstract (3)

The TGFbeta co-receptor endoglin modulates the expression and transforming potential of H-Ras
Activation of mitogen-activated protein kinase (MAPK) pathway in mesenchymal stem cells (MSC) derived from control and osteoporotic postmenopausal women.
Epidermal growth factor (EGF) stimulates urokinase expression through the ERK and JNK signaling pathways in gingival fibroblasts.
96
Juan Santibáñez

Professor of Research

Molecular Oncology

Institute for Medical Research

Belgrade, Serbia

12
Jorge Martinez

Profesor Titular

Laboratorio de Biología Celular

INSTITUTO DE NUTRICIÓN Y TECNOLOGÍA DE ALIMENTOS (INTA), UNIVERSIDAD DE CHILE

Santiago, Chile

2
Nicolas Tobar

Assistan Professor

Celullar Biology Laboratory

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS, INTA-UCHILE

Santiago, Chile

1
Claudio Olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
Rodrigo Ramirez

Consultor

Asesorias CUBO

Santiago, Chile

1
Rodrigo Troncoso

Assistant professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Monica Cáceres

PONTIFICA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

1
Alfonso González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile