Man

Julio Cesar Cardenas Matus

Assistant Professor

University of Chile

Santiago, Chile

Líneas de Investigación


our lab is interested in the mechanisms that regulated cellular metabolism and bioenergetic’s, with special emphasis in the functional relation between the endoplasmic reticulum and mitochondria

Educación

  •  Biomedical Science, UNIVERSIDAD DE CHILE. Chile, 2005
  •  Medical Technology, UNIVERSIDAD DE CHILE. Chile, 2000

Experiencia Académica

  •   Assitent professor Full Time

    UNIVERSIDAD DE CHILE

    Santiago, Chile

    Enero 2011 - A la fecha

  •   Visiting Professor Other

    UNIVERSITY OF PENNSYLVANIA

    Philadelphia, Estados Unidos

    Enero 2012 - A la fecha

Experiencia Profesional

  •   Assitant Professor Full Time

    University of Chile

    Santiago, Chile

    Enero 2011 - A la fecha

Formación de Capital Humano


2012-2013 Project advisor: Camila Godoy “Melformin induces cell death specifically in breast tumor derived cell lines”. (University of Chile, Chile).
2012-2013 Project advisor: Galdo Bustos “Determining the mechanism that drives cell death in the absence of InsP3R activity, by measuring apoptosis, autophagy and necrosis”. (University of Chile, Chile).
2013-present Bachelor Thesis advisor: Carlos Valdes, “Modulation of cellular metabolism by InsP3R inhibition: role of sirtuin 1”. (Catholic University of Valparaiso, Chile).
2013-present Bachelor Thesis advisor: Felipe Araya, “Role of InsP3R in mitochondrial dynamics”. (Austral University, Chile).
2013-present Bachelor Thesis advisor: Sebastian Merino, “Role of MCU and MCUR1 in cancer bioenergetics” (University of Chile, Chile).
2013-present Bachelor Thesis advisor: Mery Ann Hidalgo, “Determination of autophagy levels in biopsies of patients with dysferlinophaty disease”. (University of Chile, Chile).
2013-present PhD advisor: Felix Urra, “Metabolic remodeling in breast cancer: mitochondrial bioenergetics as target for the design of anti-metastatic drugs”.
2013-present Postdoctoral supervisor: Fabian Jana, “Defining the role of mitochondrial electron transport chain complex I on the modulation of Ca2+ homeostasis: effects on cancer cell metabolism”.


Premios y Distinciones

  •   Best PhD thesis award

    FUNDACION CIENCIA PARA LA VIDA

    Chile, 2005

    premio a la major tesis de doctorado del anio 2005

  •   International Travel Award

    Biophysical Society

    Estados Unidos, 2005

    trabajo en la modalidad poster premiado .

  •   Research award

    American Heart Association

    Chile, 2009

    research grant to work in atheroslcerosis


Tipos de Producción
 

Journal Article (15)

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.
MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival
Mitochondrial Ca 2+ signals in autophagy
Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.
LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.
Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by freeze-drying and rotary shadowing for electron microscopy
Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by freeze-drying and rotary shadowing for electron microscopy.
Single-channel recording of inositol trisphosphate receptor in the isolated nucleus of a muscle cell line
Nuclear inositol 1,4,5-trisphosphate receptors regulate local CA2+ tranasients and modulate cAMP response elements binding protein phosphorylation
Xestospongin B, a competitive inhibitor of IP3-mediated Ca 2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells
Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein via calcium and protein kinase C alpha
Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes
Calcium transients in 1B5 myotubes lacking ryanodine receptors are related to inositol trisphosphate receptors

Generic (2)

Nuclear IP3 receptor isoforms regulate local Ca2+ transients and modulate CREB phosphorylation
Subcellular localisation of inositol 1,4,5-trisphosphate receptors in cultured skeletal muscle from rat and mouse

Abstract (1)

Normal distribution of Ins(1,4,5)P3 receptors is disrupted in Duchenne muscular dystrophy
19
Julio Cardenas

Assistant Professor

Anatomy and Developmental Biology

University of Chile

Santiago, Chile

12
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Jorge Bevilacqua

Profesor Titular

Neurología y Neurocirugía

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, ESCUELA DE MEDICINA

Santiago, Chile

1
Steffen Hartel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
Sergio Lavandero

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Ricardo Hartley

Académico

Universidad Central de Chile

Santiago, Chile