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Felipe Alonso Simon Pino

Profesor Titular

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Sepsis induced-organ dysfunction; Vascular physiopathology during sepsis; Inflammation induced-vascular disfunction; Discovery of markers for the treatment of sepsis.

PhD in Biomedical Sciences, UNIVERSIDAD DE CHILE. Chile, 2006
Master in Physiology, UNIVERSIDAD DE CHILE. Chile, 2003
Biochemist, UNIVERSIDAD DE CHILE. Chile, 2001
Bachelor in Biochemistry, UNIVERSIDAD DE CHILE. Chile, 1999

Associate Investigator Other

UNIVERSIDAD DE CHILE

Faculty of Medicine

Santiago, Chile

1999 - 2006
Profesor Titular Full Time

UNIVERSIDAD ANDRES BELLO

Faculty of Biological Science

Santiago, Chile

2015 - A la fecha
Postdoc Full Time

UNIVERSIDAD DE CHILE

Faculty of Medicine

Santiago, Chile

2006 - 2007
Associate Professor Full Time

UNIVERSIDAD ANDRES BELLO

Faculty of Biological Science

Santiago, Chile

2013 - 2015

Investigator Other

Universidad de Chile

Santiago, Chile

1999 - 2006
Profesor Tituar Full Time

Universidad Andrés Bello

Santiago, Chile

2015 - A la fecha
Profesor Asociado Full Time

Universidad Andres Bello

Santiago, Chile

2012 - 2015
Post-doc Full Time

Universidad de Chile

Santiago, Chile

2006 - 2007

PhD Thesis (as thesis director):
- Alvaro Becerra, 2017
- Cesar Echeverría, 2013
- Lorena Perez, 2018
- Sebastian Gatica, en curso
- Alejandro Vallejos, en curso
- Yolanda Prado, en curso

Magister/undergraduate Thesis (as thesis director):
- Ivanka Jimenez, en curso
- Vicente Villegas, 2017
- Alejandro Vallejos, 2017
- Macarena Rojas, 2015
- Ignacio Montorfano, 2013
- Daniela Sarmiento, 2013
- Alvaro Becerra, 2010
- Felipe Nuñez, 2010

> 10 lab training at postgraduate level as tutor
> 20 lab training at undergraduate level as tutor
> 10 participation in postgraduate thesis as examiner.
> 15 participation in undergraduate thesis as examiner.
2 postgraduate curses as director.
> 20 undergraduate curses as director.

PhD Schoolarship

FUNDACION DE ESTUSIOS BIOMEDICOS AVANZADOS

Chile, 2004

SCHOOLARSHIP TO PERFORM PhD PROYECTS
PhD Scholarship

MINISTERIO DE EDUCACION

Chile, 2005

Scholarship for oustandings PhD students


Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis Gatica, Sebastian; Aravena, Cristobal; Prado, Yolanda; Aravena, Diego; ECHEVERRIA-LEAL, CRISTIAN MAURICIO; Santibanez, Juan; RIEDEL-SORIA, CLAUDIA ANDREA; Stehberg, Jimmy; SIMON-PINO, FELIPE ALONSO Article SCOPUS Advances in Experimental Medicine and Biology (2023)
Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells Abrigo, Johanna; Olguin, Hugo; Tacchi, Franco; Orozco-Aguilar, Josue; Valero-Breton, Mayalen; Soto, Jorge; Castro-Sepulveda, Mauricio; Elorza, Alvaro A.; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI SCIELO BIOLOGICAL RESEARCH (2023)
Contribution of viral and bacterial infections to senescence and immunosenescence Reyes, A.; Ortiz, G.; Duarte, L. F.; Fernández, C.; Hernández-Armengol, R.; Palacios, P. A.; Prado, Y.; Andrade, C. A.; Rodriguez-Guilarte, L.; Kalergis, A. M.; Simon, F.; Carreño, L. J.; Riedel, C. A.; Cáceres, M.; González, P. A. Article FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2023)
Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis Jimenez-Dinamarca, Ivanka; Prado, Yolanda; Tapia, Pablo; Gatica, Sebastian; Alt, Clemens; Lin, Charles P.; Reyes-Martinez, Cristian; Feijoo, Carmen G.; Aravena, Cristobal; Gonzalez-Canacer, Alejandra; Correa, Simon; Varela, Diego; Cabello-Verrugio, Claudio; Simon, Felipe Article ISI SCIELO BIOLOGICAL RESEARCH (2023)
Effect of Dietary Supplements with omega-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats Prado, Yolanda; Echeverria, Cesar; Feijoo, Carmen G. G.; Riedel, Claudia A. A.; Cabello-Verrugio, Claudio; Santibanez, Juan F. F.; Simon, Felipe Article ISI ANTIOXIDANTS (2023)
Effects of Adrenergic Receptor Stimulation on Human Hemostasis: A Systematic Review Gatica, Sebastian; Aravena, Diego; ECHEVERRIA-LEAL, CRISTIAN MAURICIO; Santibanez, Juan; RIEDEL-SORIA, CLAUDIA ANDREA; SIMON-PINO, FELIPE ALONSO Article SCOPUS Advances in Experimental Medicine and Biology (2023)
Novel evidence on sepsis-inducing pathogens: from laboratory to bedside Gatica, Sebastian; Fuentes, Brandon; Rivera-Asin, Elizabeth; Ramirez-Cespedes, Paula; Sepulveda-Alfaro, Javiera; Catalan, Eduardo A.; Bueno, Susan M.; Kalergis, Alexis M.; Simon, Felipe; Riedel, Claudia A.; Melo-Gonzalez, Felipe Article ISI FRONTIERS IN MICROBIOLOGY (2023)
Procoagulant phenotype induced by oxidized high-density lipoprotein associates with acute kidney injury and death Prado, Yolanda; Perez, Lorena; Eltit, Felipe; Echeverria, Cesar; Llancalahuen, Felipe M.; Tapia, Pablo; Gonzalez, Pablo A.; Kalergis, Alexis M.; Cabello-Verrugio, Claudio; Simon, Felipe Article ISI THROMBOSIS RESEARCH (2023)
Sepsis-Induced Coagulopathy Phenotype Induced by Oxidized High-Density Lipoprotein Associated with Increased Mortality in Septic-Shock Patients Prado, Yolanda; Tapia, Pablo; Eltit, Felipe; Reyes-Martinez, Cristian; Feijoo, Carmen G.; Llancalahuen, Felipe M.; Riedel, Claudia A.; Cabello-Verrugio, Claudio; Stehberg, Jimmy; Simon, Felipe Article ISI ANTIOXIDANTS (2023)
Small Plastics, Big Inflammatory Problems Prado, Yolanda; Aravena, Cristobal; Aravena, Diego; Eltit, Felipe; Gatica, Sebastian; RIEDEL-SORIA, CLAUDIA ANDREA; SIMON-PINO, FELIPE ALONSO Article SCOPUS Advances in Experimental Medicine and Biology (2023)
Statins and Hemostasis: Therapeutic Potential Based on Clinical Evidence Prado, Yolanda; Aravena, Diego; Llancalahuen, Felipe M.; Aravena, Cristobal; Eltit, Felipe; ECHEVERRIA-LEAL, CRISTIAN MAURICIO; Gatica, Sebastian; RIEDEL-SORIA, CLAUDIA ANDREA; SIMON-PINO, FELIPE ALONSO Article SCOPUS Advances in Experimental Medicine and Biology (2023)
Transforming Growth Factor-β1 in Cancer Immunology: Opportunities for Immunotherapy Villar, Víctor H.; Suboti?ki, Tijana; Dikic, Dragoslava; Mitrovi?-Ajti?, Olivera; SIMON-PINO, FELIPE ALONSO; Santibanez, Juan Article SCOPUS Advances in Experimental Medicine and Biology (2023)
Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux Orozco-Aguilar, Josue; Tacchi, Franco; Aguirre, Francisco; Valero-Breton, Mayalen; Castro-Sepulveda, Mauricio; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI SCIELO BIOLOGICAL RESEARCH (2023)
α1-Adrenergic Stimulation Increases Platelet Adhesion to Endothelial Cells Mediated by TRPC6 Llancalahuen, Felipe M.; Vallejos, Alejando; Aravena, Diego; Prado, Yolanda; Gatica, Sebastian; Otero, Carolina; SIMON-PINO, FELIPE ALONSO Article SCOPUS Advances in Experimental Medicine and Biology (2023)
Bile Acids Induce Alterations in Mitochondrial Function in Skeletal Muscle Fibers Abrigo, Johanna; Olguin, Hugo; Gutierrez, Danae; Tacchi, Franco; Arrese, Marco; Cabrera, Daniel; Valero-Breton, Mayalen; Elorza, Alvaro A.; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI ANTIOXIDANTS (2022)
Combined Administration of Andrographolide and Angiotensin- (1-7) Synergically Increases the Muscle Function and Strength in Aged Mice Abrigo, Johanna; Simon, Felipe; Cabrera, Daniel; Vilos, Cristian; Cabello-Verrugio, Claudio Article ISI CURRENT MOLECULAR MEDICINE (2022)
In Vivo and in vitro antitumor activity of tomatine in hepatocellular carcinoma Echeverria, Cesar; Martin, Aldo; Simon, Felipe; Salas, Cristian O.; Nazal, Mariajesus; Varela, Diego; Perez-Castro, Ramon A.; Santibanez, Juan F.; Valdes-Valdes, Ricardo O.; Forero-Doria, Oscar; Echeverria, Javier Article ISI FRONTIERS IN PHARMACOLOGY (2022)
Intensive care unit-acquired weakness: A review from molecular mechanisms to its impact in COVID-2019 Gonzalez, Andrea; Abrigo, Johanna; Achiardi, Oscar; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY (2022)
Oxidized High-Density Lipoprotein Induces Endothelial Fibrosis Promoting Hyperpermeability, Hypotension, and Increased Mortality Rojas, Macarena; Prado, Yolanda; Tapia, Pablo; Carreno, Leandro J.; Cabello-Verrugio, Claudio; Simon, Felipe Article ISI ANTIOXIDANTS (2022)
Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor Abrigo, Johanna; Gonzalez, Francisco; Aguirre, Francisco; Tacchi, Franco; Gonzalez, Andrea; Paz Meza, Maria; Simon, Felipe; Cabrera, Daniel; Arrese, Marco; Karpen, Saul; Cabello-Verrugio, Claudio Article ISI JOURNAL OF CELLULAR PHYSIOLOGY (2021)
Cobalt ions induce metabolic stress in synovial fibroblasts and secretion of cytokines/chemokines that may be diagnostic markers for adverse local tissue reactions to hip implants Eltit, Felipe; Noble, Jake; Sharma, Manju; Benam, Niloufar; Haegert, Anne; Bell, Robert H.; Simon, Felipe; Duncan, Clive P.; Garbuz, Donald S.; Greidanus, Nelson, V; Masri, Bassam A.; Ng, Tony L.; Wang, Rizhi; Cox, Michael E. Article ISI Acta Biomaterialia (2021)
Impact of exercise training on the sarcopenia criteria in non-alcoholic fatty liver disease: a systematic review and meta-analysis Gonzalez, Andrea; Valero-Breton, Mayalen; Huerta-Salgado, Camila; Achiardi, Oscar; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY (2021)
Redox-Dependent Effects in the Physiopathological Role of Bile Acids Orozco-Aguilar, Josue; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI Oxidative Medicine and Cellular Longevity (2021)
Scaffold biomaterials and nano-based therapeutic strategies for skeletal muscle regeneration Tacchi, Franco; Orozco-Aguilar, Josue; Gutierrez, Danae; Simon, Felipe; Salazar, Javier; Vilos, Cristian; Cabello-Verrugio, Claudio Article ISI NANOMEDICINE (2021)
The Critical Role of Oxidative Stress in Sarcopenic Obesity Gonzalez, Andrea; Simon, Felipe; Achiardi, Oscar; Vilos, Cristian; Cabrera, Daniel; Cabello-Verrugio, Claudio Article ISI Oxidative Medicine and Cellular Longevity (2021)
Angiotensin (1-7) decreases myostatin-induced NF-kb signaling and skeletal muscle atrophy Aravena J.; Abrigo J.; Gonzalez F.; Aguirre F.; Gonzalez A.; Simon F.; Cabello-verrugio C. Article ISI SCOPUS international journal of mole (2020)
Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle Rivera, Juan Carlos; Abrigo, Johanna; Tacchi, Franco; Simon, Felipe; Brandan, Enrique; Santos, Robson A.; Bader, Michael; Chiong, Mario; Cabello-Verrugio, Claudio Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Endothelial dysfunction in pregnancy metabolic disorders Echeverria, C; Eltit, F; Santibanez, JF; Gatica, S; Cabello-Verrugio, C; Simon, F Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)
N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease Abrigo, Johanna; Marin, Tabita; Aguirre, Francisco; Tacchi, Franco; Vilos, Cristian; Simon, Felipe; Arrese, Marco; Cabrera, Daniel; Cabello-Verrugio, Claudio Article ISI SCOPUS CURRENT MOLECULAR MEDICINE (2020)
Protective Effect of Angiotensin 1-7 on Sarcopenia Induced by Chronic Liver Disease in Mice Aguirre, Francisco; Abrigo, Johanna; Gonzalez, Francisco; Gonzalez, Andrea; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD) Gonzalez, Andrea; Huerta-Salgado, Camila; Orozco-Aguilar, Josue; Aguirre, Francisco; Tacchi, Franco; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI Oxidative Medicine and Cellular Longevity (2020)
Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5 Abrigo, Johanna; Campos, Fabian; Gonzalez, Francisco; Aguirre, Francisco; Gonzalez, Andrea; Huerta-Salgado, Camila; Conejeros, Sabrina; Simon, Felipe; Arrese, Marco; Cabrera, Daniel; Elorza, Alvaro A.; Cabello-Verrugio, Claudio Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
SARS-CoV-2/Renin-Angiotensin System: Deciphering the Clues for a Couple with Potentially Harmful Effects on Skeletal Muscle Gonzalez, Andrea; Orozco-Aguilar, Josue; Achiardi, Oscar; Simon, Felipe; Cabello-Verrugio, Claudio Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
TRPM Channels in Human Diseases Jimenez, Ivanka; Prado, Yolanda; Marchant, Felipe; Otero, Carolina; Eltit, Felipe; Cabello-Verrugio, Claudio; Cerda, Oscar; Simon, Felipe Article ISI CELLS (2020)
TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia Gatica S.; Villegas V.; Vallejos A.; Olivares P.; Aballai V.; Lagos-Meza F.; Echeverria C.; Cabello-Verrugio C.; Varela D.; Simon F. Article ISI SCOPUS LABORATORY INVESTIGATION (2020)
TRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Death Ramirez-Barrantes, Ricardo; Carvajal-Zamorano, Karina; Rodriguez, Belen; Cordova, Claudio; Lozano, Carlo; Simon, Felipe; Diaz, Paula; Munoz, Pablo; Marchant, Ivanny; Latorre, Ramon; Castillo, Karen; Olivero, Pablo Article ISI FRONTIERS IN PHYSIOLOGY (2020)
Circulating Endothelial Cells From Septic Shock Patients Convert to Fibroblasts Are Associated With the Resuscitation Fluid Dose and Are Biomarkers for Survival Prediction Tapia, Pablo; Gatica, Sebastian; Cortés-Rivera, Cristian; Otero, Carolina; Becerra, Alvaro; Riedel, Claudia A; Cabello-Verrugio, Claudio; Kalergis, Alexis M; Simon, Felipe Article ISI SCOPUS CRITICAL CARE MEDICINE (2019)
Copper deficiency- induced anemia is caused by a mitochondrial metabolic reprograming in erythropoietic cells Jensen, EL; Gonzalez-Ibanez, AM; Mendoza, P; Ruiz, LM; Riedel, CA; Simon, F; Schuringa, JJ; Elorza, AA Article ISI SCOPUS METALLOMICS (2019)
Endothelial Cells Exhibit Two Waves of P-selectin Surface Aggregation Under Endotoxic and Oxidative Conditions Barrionuevo N.; Gatica S.; Olivares P.; Cabello-Verrugio C.; Simon F. Article ISI SCOPUS PROTEIN JOURNAL (2019)
Endotoxemia-induced endothelial fibrosis inhibition improves hypotension, tachycardia, multiple organ dysfunction syndrome, cytokine response, oxidative stress, and survival Vallejos A.; Olivares P.; Gatica S.; Villegas V.; Echeverria C.; Cabello-Verrugio C.; Simon F. Article ISI SCOPUS LABORATORY INVESTIGATION (2019)
Expression Suppression and Activity Inhibition of TRPM7 Regulate Cytokine Production and Multiple Organ Dysfunction Syndrome During Endotoxemia: A New Target for Sepsis Gatica S.; Eltit F.; Santibanez J.F.; Varela D.; Cabello-Verrugio C.; Simon F. Article ISI SCOPUS CURRENT MOLECULAR MEDICINE (2019)
Mitochondrial Dysfunction in Skeletal Muscle Pathologies Abrigo, Johanna; Simon, Felipe; Cabrera, Daniel; Vilos, Cristian; Cabello-Verrugio, Claudio Article ISI SCOPUS CURRENT PROTEIN & PEPTIDE SCIENCE (2019)
OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-kappa B pathway on endothelial cells Perez, L; Vallejos A.; Echeverria, C; Varela, D; Cabello-Verrugio, C; Simon, F Article ISI SCOPUS LABORATORY INVESTIGATION (2019)
TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines Sagredo, Alfredo I.; Sagredo, Eduardo A.; Pola, Victor; Echeverria, Cesar; Andaur, Rodrigo; Michea, Luis; Stutzin, Andres; Simon, Felipe; Marcelain, Katherine; Armisen, Ricardo Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Critical contribution of Na+-Ca2+ exchanger to the Ca2+-mediated vasodilation activated in endothelial cells of resistance arteries Lillo, MA; Gaete, PS; Puebla M.; Ardiles, NM; Poblete, I; Becerra, A; Simon, F; Figueroa, XF Article ISI SCOPUS FASEB JOURNAL (2018)
Gestational Hypothyroxinemia Affects Its Offspring With a Reduced Suppressive Capacity Impairing the Outcome of the Experimental Autoimmune Encephalomyelitis Haensgen, H; Albornoz, E; Opazo, MC; Bugueno, K; Fernandez, ELJ; Binzberger, R; Rivero-Castillo, T; Salas, LFV; Simon, F; Cabello-Verrugio, C; Elorza, AA; Kalergis, AM; Bueno, SM; Riedel, CA Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
Preventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survival Vallejos A.; Olivares, P; Varela, D; Echeverria, C; Cabello-Verrugio, C; Perez-Leighton, C; Simon, F Article ISI FRONTIERS IN PHYSIOLOGY (2018)
Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia Abrigo, Johanna; ELorza, Alvaro A.; Riedel, Claudia A; Vilos, Cristian; Simon, Felipe; Cabrera, Daniel; Estrada, Lisbell; Cabello-Verrugio, Claudio Article ISI Oxidative Medicine and Cellular Longevity (2018)
Sarcopenia in a mice model of chronic liver disease: role of the ubiquitin-proteasome system and oxidative stress Campos, F; Abrigo, J; Aguirre, F; Garces, B.; Arrese, M; Karpen, S; Cabrera, D; Andia, ME; Simon, F; Cabello-Verrugio, C Article ISI SCOPUS PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2018)
TGF-beta requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy Cabello-Verrugio, Claudio; Riedel, Claudia; Abrigo, Johanna; Cabrera, Daniel; Simon, Felipe; Vilos, Cristian; Campos, Fabian Article ISI SCOPUS BIOLOGICAL CHEMISTRY (2018)
Transient Receptor Potential Vanilloid 1 Expression Mediates Capsaicin-Induced Cell Death Ramirez-Barrantes, Ricardo; Cordova,Claudio; Gatica, Sebastian; Rodriguez, Belen; Lozano, Carlo; Marchant, Ivanny; Echeverria, Cesar; Simon, Felipe; Olivero, Pablo Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2018)
Endothelial-to-mesenchymal transition: Cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions Pérez, Lorena; Muñoz-Durango, Natalia; Riedel, Claudia A.; Echeverría, Cesar; Kalergis, Alexis M.; Cabello-Verrugio, Claudio; Simon, Felipe Article ISI SCOPUS CYTOKINE & GROWTH FACTOR REVIEWS (2017)
Human Peritoneal Mesothelial Cell Death Induced by High-Glucose Hypertonic Solution Involves Ca2+ and Na+ Ions and Oxidative Stress with the Participation of PKC/NOX2 and PI3K/Akt Pathways Simon, Felipe; Tapia, Pablo; Armisen, Ricardo; Echeverria, Cesar; Gatica, Sebastian; Vallejos, Alejandro; Pacheco, Alejandro; Sanhueza, Maria E.; Alvo, Miriam; Segovia, Erico; Torres, Rubén Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2017)
Imprinting of maternal thyroid hormones in the offspring Opazo, MC; Haensgen, H; Bohmwald, K; Venegas, LF; Boudin, H; Elorza, AA; Simon F.; Fardella, C.; Bueno, SM; Kalergis, AM; Riedel, CA Article ISI SCOPUS INTERNATIONAL REVIEWS OF IMMUNOLOGY (2017)
Oxidative Stress in Disease and Aging: Mechanisms and Therapies 2016 Cabello-Verrugio, Claudio; Simon, Felipe; Trollet, Capucine; Santibañez, Juan F. Article ISI SCOPUS Oxidative Medicine and Cellular Longevity (2017)
TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells Sagredo, A; Sagredo, E.; Cappelli, C; Báez, P; Andaur, R; Blanco, C; Tapia, J.; Echeverría, C; Cerda, O; Stutzin, A.; Simon, F.; Marcelain, K; Armisén, R Article ISI Molecular Oncology (2017)
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas Morales M.G.; Abrigo, J; Acuna M.J.; Santos R.A.; Bader M.; Brandan, E.; Simon F.; Olguin, H; cabrera, D; Cabello-Verrugio C. Article ISI SCOPUS DMM Disease Models and Mechanisms (2016)
The characterization of anti-T. cruzi activity relationships between ferrocenyl, cyrhetrenyl complexes and ROS release Echeverría, César; Romero, Valentina; Arancibia, Rodrigo; Klahn, Hugo; Montorfano, Ignacio; Armisen, Ricardo; Borgna, Vincenzo; Simon, Felipe; Ramírez-Tagle, Rodrigo Article ISI SCOPUS BIOMETALS (2016)
Transforming growth factor type beta (TGF-?) requires reactive oxygen species to induce skeletal muscle atrophy Abrigo, J; Rivera J.C.; Simon F.; cabrera, D; Cabello-Verrugio C. Article ISI SCOPUS Cellular Signalling (2016)
Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism Cisternas, F.; Morales, MG; Meneses, C.; Simon F.; Brandan, E.; Abrigo, J; Vazquez, Y; Cabello-Verrugio, C Article ISI CLINICAL SCIENCE (2015)
Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism. Cisternas F, Morales MG, Meneses C, Simon F, Brandan E, Abrigo J, Vazquez Y, Cabello-Verrugio C. Article Clinical Science (2015)
Apocynin inhibits the upregulation of TGF-beta(1) expression and ROS production induced by TGF-beta in skeletal muscle cells Abrigo, J; Morales, MG; Simon F.; cabrera, D; Di CApua G; Cabello-Verrugio, C Article ISI SCOPUS Phytomedicine (2015)
Ca-v beta(2) transcription start site variants modulate calcium handling in newborn rat cardiomyocytes Moreno C.; Hermosilla T.; Morales, D; Encina, M; Torres-Diaz, L; Díaz P; Sarmiento D.; Simon F.; Varela D. Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism Morales, MG; Olguin, H; Di CApua G; Brandan, E.; Simon F.; Cabello-Verrugio, C Article ISI SCOPUS Clinical Science (2015)
Excess Iodide Induces an Acute Inhibition of the Sodium/Iodide Symporter in Thyroid Male Rat Cells by Increasing Reactive Oxygen Species Arriagada, AA; Albornoz, E; Opazo, MC; Becerra, A; Vidal G.; Fardella, C.; Michea, L.; Carrasco N.; Simon F.; Elorza, AA; Bueno, SM; Kalergis, AM; Riedel, CA Article ISI SCOPUS Endocrinology (2015)
Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species. Arriagada AA, Albornoz E, Opazo MC, Becerra A, Vidal G, Fardella C, Michea L, Carrasco N, Simon F, Elorza AA, Bueno SM, Kalergis AM, Article Endocrinology (2015)
Multifunctional polymeric nanoparticles doubly loaded with SPION and ceftiofur retain their physical and biological properties Solar P.; Gonzalez G. ; Vilos C.; Herrera, N; Juica, N; Moreno, M.; Simon F.; Velasquez L. Article ISI SCOPUS Journal of Nanobiotechnology (2015)
Multifunctional polymeric nanoparticles doubly loaded with SPION and ceftiofur retain their physical and biological properties Solar P, González G, Vilos C, Herrera N, Juica N, Moreno M, Simon F, Velásquez L. Article Journal of Nanobiotechnology (2015)
Preclinical Development and In Vivo Efficacy of Ceftiofur-PLGA Microparticles Cristian Vilos, Luis A Velasquez, Paula I Rodas, Katherine Zepeda, Soung-Jae Bong, Natalia Herrera, Mario Cantin, Felipe Simon, Luis Constandil Article PLOS ONE (2015)
Preclinical Development and In Vivo Efficacy of Ceftiofur-PLGA Microparticles Vilos C.; Velasquez LA; Rodas, PI; Zepeda K; Bong, SJ; Herrera, N; Cantin, M; Simon F.; Constandil, L Article ISI SCOPUS PLOS ONE (2015)
Renin-Angiotensin system: an old player with novel functions in skeletal muscle Cabello-Verrugio C.; Morales MG.; Rivera JC.; Cabrera D.; Simon F Article MEDICINAL RESEARCH REVIEW (2015)
Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide Nardocci, G; Martin A.; Abarzua S.; Rodriguez J.; Simon F.; Reyes E.P.; Acuna-Castillo, C; Navarro, C.; Cortes P.P.; Fernandez, R. Article ISI SCOPUS JOURNAL OF NEUROIMMUNOLOGY (2015)
Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide. Nardocci G, Martin A, Abarzúa S, Rodríguez J, Simon F, Reyes EP, Acuña-Castillo C, Navarro C, Cortes PP, Fernández R. Article Journal of Neuroimmunology (2015)
Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway Echeverria, C.; Montorfano I.; Cabello-Verrugio, C; Armisen, R; Varela D.; Simon F. Article ISI SCOPUS Journal of Hypertension (2015)
Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway Echeverría C, Montorfano I, Cabello-Verrugio C, Armisén R, Varela D, Simon F. Article JOURNAL OF HYPERTENSION (2015)
The angiotensin-(1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice Meneses, C.; Morales M.; Abrigo, J; Simon F.; Brandan, E.; Cabello-Verrugio, C Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility Cáceres M.; Ortiz, L; Recabarren, T; Romero A.; Colombo, A; Leiva-Salcedo, E; Varela D.; Rivas J.; Silva I.; Morales, D; Campusano, C; Almarza O.; Simon F.; Toledo, H; Park, KS; Trimmer, JS; Cerda O. Article ISI SCOPUS PLOS ONE (2015)
Adaptive Responses of Mitochondria to Mild Copper Deprivation Involve Changes in Morphology, OXPHOS Remodeling and Bioenergetics Ruiz, LM; Jensen, EL; Bustos, RI; Arguelloa, G; Gutierrez-Garcia, R; Gonzalez, M.; Hernandez C.; Paredes, R.; Simon F.; Riedel C.; Ferrick, D.; Elorza, AA Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2014)
Angiotensin 1-7 Decreases Skeletal Muscle Atrophy induced by Angiotensin II through Mas Receptor Dependent Mechanism. Cisternas, F; Morales, MG; Meneses, C; Simon, F; Brandan, E; Abrigo, J; Vazquez, Y; Cabello-Verrugio, C. Article ISI CLINICAL SCIENCE (2014)
Endotoxin Induces Fibrosis in Vascular Endothelial Cells through a Mechanism Dependent on Transient Receptor Protein Melastatin 7 Activity Echeverría, Cesar; Montorfano, Ignacio; Hermosilla, Tamara; Armisén, Ricardo; Velásquez, Luis A.; Cabello-Verrugio, Claudio; Varela, Diego; Simon, Felipe; Li, Liwu Article ISI SCOPUS PLOS ONE (2014)
Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity Echeverría C ; Montorfano I; Hermosilla T ; Armisén R; Velásquez LA; Cabello-Verrugio C ; Varela D; Simon F. Article PLOS ONE (2014)
Endotoxin-Induced Endothelial Fibrosis Is Dependent on Expression of Transforming Growth Factors β1 and β2 Echeverría, Cesar; Montorfano, Ignacio; Tapia, Pablo; Cabello-Verrugio, Claudio; Simon, Felipe Article ISI INFECTION AND IMMUNITY (2014)
Endotoxin-induced endothelial fibrosis is dependent on the expression of TGF-beta1 and TGF-beta2 Echeverría C.; Montorfano I.; Tapia P.; Riedel C.; Cabello-Verrugio C.; Simon F Article INFECTION AND IMMUNITY (2014)
Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-kappa B pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity Sarmiento, Daniela; Montorfano, Ignacio; Cáceres, Mónica; Echeverría, Cesar; Fernandez, Ricardo; Cabello-Verrugio, Claudio; Cerda, Oscar; Tapia, Pablo; Simon, Felipe Article ISI SCOPUS INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)
Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-kappaB pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity. Sarmiento D.; Montorfano I.; Cáceres M.; Echeverría C.; Fernández R.; Cabello-Verrugio C.; Cerda O.; Tapia P.; Simon F. Article THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)
Expression of the Mas receptor is upregulated in skeletal muscle wasting Morales M.G.; Abrigo, J; Meneses, C.; Cisternas, F.; Simon F.; Cabello-Verrugio C. Article ISI SCOPUS Histochemistry and Cell Biology (2014)
Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel Sarmiento, D; Montorfano, I; Cerda, O; Cáceres, M; Becerra, A; Cabello-Verrugio, C; Elorza, AA; Riedel, C; Tapia, P; Velazquez, L; Varela, D; Simon, F. Article ISI MICROVASCULAR RESEARCH (2014)
Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel. Microvascular Research. Sarmiento D, Montorfano I, Cerda O, Cáceres M, Becerra A, Cabello-Verrugio C, Elorza AA, Riedel C, Tapia P, Velásquez LA, Varela D, Simon F; Montorfano I; Cerda O; Cáceres M; Becerra A; Cabello-Verrugio C; Elorza AA; Riedel C; Tapia P; Velásquez LA; Varela D; Simon F Article Microvascular Research (2014)
Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-beta 1 and TGF-beta 2-dependent pathway Montorfano, Ignacio; Becerra, Alvaro; Cerro, Roberto; Echeverría, Cesar; Sáez, Elizabeth; Morales, Maria Gabriela; Fernandez, Ricardo; Cabello-Verrugio, Claudio; Simon, Felipe Article ISI SCOPUS LABORATORY INVESTIGATION (2014)
Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-beta1 and TGF-beta2-dependent pathway. Montorfano I.; Becerra A.; Cerro R.; Echeverría C.; Sáez E.; Morales M.; Fernández R.; Cabello-Verrugio C.; Simon F Article LABORATORY INVESTIGATION (2014)
Role of astrocytes in memory and psychiatric disorders. Moraga-Amaro, R; Jerez-Baraona, JM; Simon, F; Stehberg, J. Article ISI JOURNAL OF PHYSIOLOGY-PARIS (2014)
Role of the insular cortex in taste familiarity Moraga-Amaro, R; Cortes-Rojas A.; Simon F.; Stehberg, J Article ISI NEUROBIOLOGY OF LEARNING AND MEMORY (2014)
Role of the insular cortex in taste familiarity Moraga-Amaro R ; Cortés A; Simon F; Stehberg J Article Neurobiology Learning and Memory (2014)
The Ang-(1-7)/Mas-1 axis attenuates the expression and signalling of TGF-beta 1 induced by AngII in mouse skeletal muscle Morales, MG; Abrigo, J; Meneses, C.; Simon F.; Cisternas, F.; Rivera, JC; Vazquez, Y; Cabello-Verrugio, C Article ISI SCOPUS CLINICAL SCIENCE (2014)
The Ang-(1-7)/Mas-1 axis attenuates the expression and signalling of TGF-beta1 induced by AngII in mouse skeletal muscle Morales MG; Abrigo J; Meneses C; Simon F; Cisternas F; Rivera JC; Vazquez Y; Cabello-Verrugio C. Article Clinical Science (2014)
The Ang-(1-7)/Mas-1 axis attenuates the expression and signalling of TGF-β1 induced by AngII in mouse skeletal muscle Morales, MG; Abrigo, J; Meneses, C; Simon, F; Cisternas, F; Rivera, JC; Vazquez, Y; Cabello-Verrugio, C. Article ISI CLINICAL SCIENCE (2014)
The angiotensin-(1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice. Meneses C, Morales MG, Abrigo J, Simon F, Brandan E, Cabello-Verrugio C. Article Pflugers Arch. (2014)
Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up-regulation of MFN2 and OPA1 in erythropoietic cells Bustos, RI; Jensen, EL; Ruiz, LM; Rivera S.; Ruiz S.; Simon F.; Riedel C.; Ferrick, D.; Elorza, AA Article ISI SCOPUS Biochemical and Biophysical Research Communications (2013)
Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons Henriquez, B; Bustos, FJ; Aguilar R.; Becerra, A; Simon F.; Montecino, M.; van Zundert, B Article ISI SCOPUS MOLECULAR AND CELLULAR NEUROSCIENCE (2013)
Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells Echeverría, C; Montorfano, I; Sarmiento, D; Becerra, A; Nunez-Villena, F; Figueroa XF; Cabello-Verrugio, C; Elorza AA.; Riedel C.; Simon F. Article JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2013)
Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells Echeverria, C.; Montorfano I.; Sarmiento D.; Becerra, A; Nunez-Villena, F; Figueroa, XF; Cabello-Verrugio, C; Elorza, AA; Riedel C.; Simon F. Article ISI SCOPUS Journal of Cellular and Molecular Medicine (2013)
Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans. Simon, F.; Varela, D,; Cabello-Verrugio, C. Article Cellular Signalling (2013)
Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells Morales, M. G.; Vazquez, Y.; Acuna, M. J.; Rivera, J. C.; Simon, F.; Salas, J. D.; Alvarez, J.; Brandan, E.; Cabello-Verrugio, C. Article THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)
Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells Morales M.G.; Vazquez, Y; Acuna M.J.; Rivera J.C.; Simon F.; Salas J.D.; Alvarez Ruf J; Brandan, E.; Cabello-Verrugio, C Article ISI SCOPUS International Journal of Biochemistry and Cell Biology (2012)
Effectiveness of short-term 6-hour high-volume hemofiltration during refractory severe septic shock Tapia, P; Chinchon, E; Morales, D; Stehberg, J; Simon F. Article SCOPUS Journal of Trauma and Acute Care Surgery (2012)
Effectiveness of short-term 6-hour high-volume hemofiltration during refractory severe septic shock Tapia P.; Chinchon E.; Morales, D; Stehberg J.; Simon F. Article JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2012)
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala Stehberg, J; Moraga-Amaro, R; Salazar C.; Becerra, A; Echeverria, C.; Orellana J.A.; Bultynck G.; Ponsaerts, R; Leybaert, L; Simon F.; Sáez, J.C.; Retamal M.A. Article ISI SCOPUS FASEB Journal (2012)
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala Stehberg J.; Moraga-Amaro R.; Salazar C.; Becerra A.; Echeverría.; Orellana JA.; Bultynck G.; Ponsaerts R.; Leybaert L.; Simon F.; Sáez JC.; Retamal MA. Article THE FASEB JOURNAL (2012)
The paramagnetic and luminescent [Re6Se8I6](3-) cluster. Its potential use as an antitumoral and biomarker agent Echeverria, C.; Becerra, A; Nunez-Villena, F; Munoz-Castro, A; Stehberg, J; Zheng, Z; Arratia-Perez, R; Simon F.; Ramirez-Tagle, R Article ISI SCOPUS New Journal of Chemistry (2012)
The paramagnetic and luminescent [Re6Se8I6](3-) cluster. Its potential use as an antitumoral and biomarker agent Echeverria C.; Becerra A.; Nunez-Villena F.; Munoz-Castro, A.; Stehberg J.; Zheng, ZP; Arratia-Perez, R.; Simon F.; Ramirez-Tagle R. Article NEW JOURNAL OF CHEMISTRY (2012)
Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells Cabello-Verrugio C.; Acuna, MJ; Morales, MG; Becerra A.; Simon F.; Brandan E. Article BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells Cabello-Verrugio, C; Acuña MJ; Morales, MG; Becerra, A; Simon F.; Brandan, E. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2011)
Increased Expression of the Transient Receptor Potential Melastatin 7 Channel Is Critically Involved in Lipopolysaccharide-Induced Reactive Oxygen Species-Mediated Neuronal Death Nunez-Villena F.; Becerra A.; Echeverria C.; Briceno N.; Porras O.; Armisen R.; Varela D.; Montorfano I.; Sarmiento D.; Simon F. Article ANTIOXIDANTS & REDOX SIGNALING (2011)
Increased Expression of the Transient Receptor Potential Melastatin 7 Channel Is Critically Involved in Lipopolysaccharide-Induced Reactive Oxygen Species-Mediated Neuronal Death Nunez-Villena, F; Becerra, A; Echeverria, C.; Briceno, N; Porras O.; Armisen, R; Varela D.; Montorfano I.; Sarmiento D.; Simon F. Article ISI SCOPUS Antioxidants and Redox Signaling (2011)
Involvement of the insular cortex in retention of conditioned taste aversion is not time dependent Stehberg, J; Simon F. Article ISI SCOPUS Neurobiology of Learning and Memory (2011)
Involvement of the insular cortex in retention of conditioned taste aversion is not time dependent Stehberg J.; Simon F. Article NEUROBIOLOGY OF LEARNING AND MEMORY (2011)
Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome Fernandez, R.; Nardocci, G; Simon F.; Martin A.; Becerra, A; Rodriguez Tirado C; Maisey, KR; Acuna-Castillo, C; Cortes, PP Article ISI SCOPUS Respiratory Physiology and Neurobiology (2011)
Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome Fernandez R.; Nardocci G.; Simon F.; Martin A.; Becerra A.; Rodriguez-Tirado C.; Maisey, KR; Acuna-Castillo C.; Cortes, PP Article RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2011)
The role of the insular cortex in taste function Stehberg, J; Moraga-Amaro, R; Simon F. Article ISI SCOPUS Neurobiology of Learning and Memory (2011)
The role of the insular cortex in taste function Stehberg J.; Moraga-Amaro R.; Simon F. Article NEUROBIOLOGY OF LEARNING AND MEMORY (2011)
Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death Becerra, A; Echeverria, C.; Varela D.; Sarmiento D.; Armisen, R; Nunez-Villena, F; Montecinos, M; Simon F. Article ISI SCOPUS Cardiovascular Research (2011)
Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death Becerra A.; Echeverria C.; Varela D.; Sarmiento D.; Armisen R.; Nunez-Villena F.; Montecinos M.; Simon F. Article CARDIOVASCULAR RESEARCH (2011)
TRPM4 Enhances Cell Proliferation Through Up-Regulation of the beta-Catenin Signaling Pathway Armisen, R; Marcelain, K; Simon F.; Tapia, JC; Toro, J.; Quest, AFG; Stutzin A. Article ISI SCOPUS Journal of Cellular Physiology (2011)
TRPM4 Enhances Cell Proliferation Through Up-Regulation of the beta-Catenin Signaling Pathway Armisen R.; Marcelain K.; Simon F.; Tapia, JC; Toro J.; Quest, AFG; Stutzin A. Article JOURNAL OF CELLULAR PHYSIOLOGY (2011)
Hydrogen Peroxide Removes TRPM4 Current Desensitization Conferring Increased Vulnerability to Necrotic Cell Death Simon F.; Leiva-Salcedo E.; Armisen R.; Riveros A.; Cerda O.; Varela D.; Eguiguren, AL; Olivero, P; Stutzin A. Article JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Hydrogen Peroxide Removes TRPM4 Current Desensitization Conferring Increased Vulnerability to Necrotic Cell Death Simon F.; Leiva-Salcedo, E; Armisen, R; Riveros A.; Cerda O.; Varela D.; Eguiguren, AL; Olivero P.; Stutzin A. Article ISI SCOPUS Journal of Biological Chemistry (2010)
P2X4 Activation Modulates Volume-sensitive Outwardly Rectifying Chloride Channels in Rat Hepatoma Cells Varela D.; Penna, A; Simon F.; Eguiguren, AL; Leiva-Salcedo, E; Cerda O.; Sala F.; Stutzin A. Article ISI SCOPUS Journal of Biological Chemistry (2010)
P2X4 Activation Modulates Volume-sensitive Outwardly Rectifying Chloride Channels in Rat Hepatoma Cells Varela D.; Penna A.; Simon F.; Eguiguren, AL; Leiva-Salcedo E.; Cerda O.; Sala F.; Stutzin A. Article JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Early lipopolysaccharide-induced reactive oxygen species production evokes necrotic cell death in human umbilical vein endothelial cells Simon F.; Fernandez, R. Article ISI SCOPUS JOURNAL OF HYPERTENSION (2009)
Early lipopolysaccharide-induced reactive oxygen species production evokes necrotic cell death in human umbilical vein endothelial cells Simon F.; Fernandez R. Article JOURNAL OF HYPERTENSION (2009)
Protein kinase C-mediated phosphorylation of p47(phox) modulates platelet-derived growth factor-induced H(2)O(2) generation and cell proliferation in human umbilical vein endothelial cells Simon F.; Stutzin A. Article ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH (2008)
Protein kinase C-mediated phosphorylation of p47(phox) modulates platelet-derived growth factor-induced H(2)O(2) generation and cell proliferation in human umbilical vein endothelial cells Simon F.; Stutzin A. Article ISI SCOPUS ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH (2008)
Activation of H2O2-induced VSOR CI(-)currents in HTC cells require phospholipase C gamma 1 phosphorylation and Ca2+ mobilisation Varela D.; Simon F.; Olivero P.; Armisen, R; Leiva-Salcedo, E; Jorgensen, F; Sala F.; Stutzin A. Article ISI SCOPUS CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2007)
Hydroxyl radical activation of a Ca2+-sensitive nonselective cation channel involved in epithelial cell necrosis Simon F.; Varela D.; Eguiguren, AL; Diaz, LF; Sala F.; Stutzin A. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)
NAD(P)H oxidase-derived H2O2 signals chloride channel activation in cell volume regulation and cell proliferation Varela D.; Simon F.; Riveros A.; Jorgensen, F; Stutzin A. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The volume-activated chloride current depends on phospholipase c activation and intracellular calcium mobilization Varela D.; Simon F.; Riveros A.; Jorgensen, F; Stutzin A. Article ISI ADVANCES IN MATERNAL-FETAL BIOMEDICINE (2004)
Non-selective cation channels and oxidative stress- induced cell swelling Simon F.; Varela D.; Riveros A.; Eguiguren, AL; Stutzin A. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2002)


Lipopolysaccharide-induced skeletal muscle atrophy is prevented by Angiotensin (1-7) via Mas receptor. Morales, MG; Olguin, HH; Brandan, E.; Simon F.; Cabello-Verrugio, C Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
The TRPM4 channel regulates the Epithelial-Mesenchymal transition in prostate cancer cells Sagredo A; Sagredo, E; Salamanca, E.; Luco, C; Andaur R,; Michea, L.; Simon F.; Tapia J.; Marcelain, K; Armisen, R Abstract ISI FEBS JOURNAL (2014)
Transforming growth factor type beta 1 (TGF-beta 1) induces skeletal muscle atrophy by a mechanism dependent of NADPH oxidase-induced reactive oxygen species. Abrigo, J; Morales, MG; Simon F.; Cabello-Verrugio, C Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
Vascular endothelial fibrosis induced by endotoxin: characteristics, mechanism and therapeutic perspectives Simon F.; Echeverria, C.; Montorfano I.; Becerra, A; Varela D.; Hermosilla T.; Cabello-Verrugio, C; Armisen, R Abstract ISI CARDIOVASCULAR RESEARCH (2014)
Polycomb-Group proteins (PcG) Ezh1 and Ezh2 differentially regulate PSD-95 gene expression in developing hippocampal neurons. Henriquez, B; Bustos, FJ; Blanco F.; Becerra, A; Salas C.; Simon F.; Montecino, M.; van Zundert, B Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2012)
Platelet-derived growth factor (PDGF) increases intracellular ROS by NAD(P)H oxidase activation in endothelial cells Simon F.; Stutzin A. Abstract PLACENTA (2006)
Production of reactive oxygen species induced by lipopolysaccharide in endothelial cells Simon F.; Fernandez, R. Abstract PLACENTA (2006)
Protons and calcium modulate the open probability of a non selective cation channel in epithelial cells Leiva-Salcedo, E; Varela D.; Simon F.; Stutzin A. Abstract PLACENTA (2006)


Oxidative Stress in Disease and Aging: Mechanisms and Therapies Cabello-Verrugio, C; Ruiz-Ortega, M; Mosqueira, M; Simon F. EditorialMaterial ISI SCOPUS Oxidative Medicine and Cellular Longevity (2016)


Endotoxin-Induced Endothelial Fibrosis Is Dependent on Expression of Transforming Growth Factors beta 1 and beta 2 (vol 82, pg 3678, 2014) Echeverria, C.; Montorfano I.; Tapia, P; Riedel C.; Cabello-Verrugio C.; Simon F. Errata ISI SCOPUS INFECTION AND IMMUNITY (2015)


Central role of transforming growth factor type beta 1 in skeletal muscle dysfunctions: An update on therapeutic strategies Abrigo J.; Simon F.; Cabrera D.; CÃ³rdova G.; Trollet C.; Cabello-Verrugio C. Review ISI SCOPUS (2018)
Transforming growth factor-beta family: Advances in vascular function and signaling Gatica S.; Cabello-Verrugio C.; Simon F. Review ISI SCOPUS (2018)
Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone Munoz-Durango, N; Vecchiola, A; Gonzalez-Gomez, LM; Simon F.; Riedel, CA; Fardella, CE; Kalergis, AM Review ISI SCOPUS BioMed Research International (2015)
Renin-Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle Cabello-Verrugio, C; Morales, MG; Rivera, JC; cabrera, D; Simon F. Review ISI SCOPUS Medicinal Research Reviews (2015)
Role of astrocytes in memory and psychiatric disorders Moraga-Amaro, R; Jerez-Baraona, JM; Simon F.; Stehberg, J Review ISI SCOPUS JOURNAL OF PHYSIOLOGY-PARIS (2014)
Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans Simon F.; Varela D.; Cabello-Verrugio, C Review ISI SCOPUS Cellular Signalling (2013)

128

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

Alvaro Elorza

FULL PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Cristian Vilos

Académico Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

Alvaro Becerra

Profesor Asociado

Ciencias Químico y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

Sebastián Gatica

Investigador Postdoctoral

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

Ricardo Fernández

Associate Professor

Salud

Universidad de Los Lagos

Osorno, Chile

Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

Andrea González

Docente

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

Pablo Tapia

Jefe Técnico Unidad de Paciente Crítico (UPC)

Unidad Paciente Critico (UPC)

Hospital Clinico Metropolitano La Florida

Santiago, Chile

Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

Ana Riveros

Profesor Asistente

Departamento de Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

Darwin Leiva

Assistant professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

Juan Rivera

Investigador

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

Rodrigo Moraga

Postdoctoral researcher

Nuklear Medizin

Medizinische Hochschule Hannover

Hannover, Alemania

Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

Maria Opazo

Profesor Asociado

Universidad de Las Américas

Santiago, Chile

Rodrigo Ramírez

Director

Direccion de Investigacion y Postgrado

Universidad de Aconcagua

Santiago, Chile

María Acuña

Directora de Investigación, académico e investigador

Universidad Bernardo O´Higgins

Santiago, Chile

Yaneisi Vazquez

Directora técnica de proyectos

Genética Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Alfredo Sagredo

Investigador Postdoctoral

ICBM

Universidad de Chile

Santiago, Chile

Omar Porras

Assistant professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

Ivanny Marchant

Directora Unidad de Estudios Clínicos

ESCUELA DE MEDICINA UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Gino Nardocci

Investigador / Profesor Asistente

Universidad de Los Andes

Santiago, Chile

Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

Berta Henriquez

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

JULIO TAPIA

Full Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Eduardo Sagredo

Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Julio Tapia

Profesor Asociado

Oncologia Basico Clinica

Universidad de Chile

Santiago, Chile

Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

Juan Santibáñez

Professor of Research

Molecular Oncology

Institute for Medical Research

Belgrade, Serbia

Claudio Cordova

Investigador asistente

Medicina

Universidad de Valparaíso

Valparaíso, Chile

Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Marcelo Andia

Associate Professor

Radiology

Pontificia Universidad Catolica de Chile

Santiago, Chile

Antonello Penna

Profesor Asociado

Anestesiología y Medicina Perioperatoria

Universidad de Chile

Santiago, Chile

Carolina Rodriguez

Investigador Docente (Postdoc)

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

Claudio Perez

Profesor Asistente

Departamento de Ciencias Fisiológicas

Pontificia Universidad Catolica de Chile

Santiago, Chile

Rodrigo Aguilar

Assistant Professor

Institute for Biomedical Sciences

Universidad Andrés Bello

Santiago, Chile

Lina Ruiz

Academico Docente Investigador

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Kevin Maisey

Profesor Asistente

Centro de Biotecnología Acuícola

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

NATALIA JUICA

Bioquímico

Facultad de Ciencias de la Salud

Universidad SEK

Santiago, Chile

Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Belen Rodriguez

Jefa de Calidad

Departamento de Patología

Universidad de Valparaíso

Viña del Mar, Chile

Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

Rodrigo Arancibia

PUCV

Valparaiso, Chile

Alejandro Arriagada

Coordinador y docente

Núcleo de Ciencias Biológicas

Universidad Mayor de Chile

Santiago, Chile

Guillermo González

Academico

Quimica

Universidad de Chile

Santiago, Chile

Luis Constandil

Profesor Titular

Biología

Universidad de Santiago de Chile

Santiago, Chile

Antonello Penna

Profesor Asociado

UNIVERSIDAD DE CHILE

Santiago, Chile

Ramiro Arratia

DIRECTOR DOCTORADO

CIENCIAS QUIMICAS

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Camilo Campusano

Doctorante

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

carlo lozano

Profesor asociado

Facultad de Medicina

Universidad de Valparaíso

Valparaíso, Chile

Ricardo Ramírez

Coordinador académico

Universidad Andrés Bello

Viña del Mar, Chile

Luis Venegas

Bioquímico/investigador

Anatomía Patológica

Clínica Alemana de Santiago

Santiago, Chile

Paula Solar

Directora de Investigación y Posgrado

Dirección de Investigación y Posgrado

Universidad SEK

Santiago, Chile

Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Alejandro Vallejos

Asistente de Investigación

Ciencias de la Vida

Laboratorio de Fisiopatología Integrativa

Santiago, Chile

MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Alvaro Muñoz

Full time professor

Dirección de Investigación y Postgrado

Universidad Autónoma de Chile

Santiago, Chile

Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

Martín Montecino

Director

Institute of Biomedical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Natalia Muñoz

Estudiante de Doctorado y Jefe Alterno_Proyecto COPEC-UC R772

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Mabel Moreno

Profesor

Universidad SEK

Santiago, Chile

RODOLFO PAREDES

Medical Education and Clinical Simulation Director

Academic Vice Rectory

UNIVERDAD ANDRÉS BELLO

Santiago, Chile

Karen Bohmwald

Investigador Postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

Mauricio Retamal

Associate Professor

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Alvaro Muñoz

Profesor Titular

Universidad San Sebastián

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

GRACIELA ARGÜELLO

Académico

Universidad Católica del Maule

Curicó, Chile

Fernando Bustos

Profesor Asistente

Facultad de Medicina

Universidad Andres Bello

Santiago, Chile

Katherine Zepeda

alumno tesista

Quimica y Biologia

Universidad de Santiago de Chile

Santiago, Chile

Pablo Díaz

Professional/Scientific advisor

Scientific Affairs

Instituto de Salud Públida de Chile

santiago, Chile

Pablo Olivero

Profesor Adjunto

Patologia y Fisiologia

Universidad de Valparaiso

Valparaíso, Chile

ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

Ricardo Gutierrez

Eduardo Catalán

Lab Manager

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Cristian Moreno

Postod

The Solomon H. Snyder Department of Neuroscience

Johns Hopkins University

Maryland, Estados Unidos

Tatiana Recabarren

Research assistant FONDECYT regular 1211931

Universidad San Sebastián

Concepción, Chile

Felipe Alonso Simon Pino

Líneas de Investigación

Educación

PhD in Biomedical Sciences, UNIVERSIDAD DE CHILE. Chile, 2006

Master in Physiology, UNIVERSIDAD DE CHILE. Chile, 2003

Biochemist, UNIVERSIDAD DE CHILE. Chile, 2001

Bachelor in Biochemistry, UNIVERSIDAD DE CHILE. Chile, 1999

Experiencia Académica

Associate Investigator Other

Profesor Titular Full Time

Postdoc Full Time

Associate Professor Full Time

Experiencia Profesional

Investigator Other

Profesor Tituar Full Time

Profesor Asociado Full Time

Post-doc Full Time

Formación de Capital Humano

Premios y Distinciones

PhD Schoolarship

PhD Scholarship

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