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Enrique Brandan Siques

Profesor Titular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Molecular mechanisms that regulate skeletal muscle formation and how they are affected in skeletal muscular dystrophies.

Cell Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1985
Biology, UNIVERSIDAD DE CHILE. Chile, 1979

Research Assistant Full Time

VANDERBILT UNIVERSITY

Nashville, Estados Unidos

1979 - 1981
PostDoctoral Fellow Full Time

SAINT LOUIS UNIVERSITY

Medicine

Saint Louis, Estados Unidos

1985 - 1986
Postdoctoral fellow Full Time

University of Massachusetts

Medicine

Worcester, Estados Unidos

1986 - 1987
Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biologicas

Santiago, Chile

1988 - 1992
Associate Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biologicas

Santiago, Chile

1992 - 1998
Full Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biológicas

Chile

1989 - A la fecha
Full Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Ciencias Biologicas

Santiago, Chile

1999 - A la fecha

Research Associate Full Time

Vanderbilt University

Nashville, Estados Unidos

1979 - 1981
Visiting Assistant Research Professor Full Time

St. Louis University

Saint Louis, Estados Unidos

1986 - 1987
Assistant Professor Full Time

University of Massachusetts

Worcester, Estados Unidos

1987 - 1988
Profesor Asistente Full Time

P. Universidad Católica de Chile

Santiago, Chile

1988 - 1992
Profesor Asociado Full Time

P. Universidad Católica de Chile

Santiago, Chile

1992 - 1998
Profesor Titular Full Time

P. Universidad Católica de Chile

Santiago, Chile

1999 - A la fecha
Profesor/Investigador Full Time

Fundación Ciencia & VIda

Chile

2019 - A la fecha

Student: Winston Andrade
Career: Biology. Faculty of Biological Sciences, P. Universidad Católica de Chile.
Title: Composition, characterization and expression of proteoglycans in the extracellular matrix of rat skeletal muscle.
Duration: 1990-1991.

Student: Alejandro Campos.
Career: Biochemistry, Universidad de Concepción.
Title: Hydrophobic proteoglycans present on the surface of the skeletal muscle.
Duration: Octubre 1991-1993.

Student: Rebeca Nuñez.
Career: Biochemistry, University of Santiago.
Title: Differential expression of extracellular matrix sulfated macromolecules, during differentiation of the glands of the chick embryo.
Duration: 1991-1992.
Dr. Cecilia Köenig as Co-adviser.

Student: Jorge Cáceres.
Career: Biochemistry, Universidad de Concepción.
Title: Alzheimer: Interaction between ?-amyloid protein and extracellular matrix.
Duration: 1993-1994.

Student: Luis Fuentealba.
Career: Biochemistry, Universidad de Concepción.
Title: Synthesis, expression and function of syndecan-3 during myogenesis.
Duration: 1998-1999.

Student: Karin Alvarez.
Career: Biochemistry, Universidad Austral de Chile.
Title: Proteoglycan synthesis and expression in patients with Duchenne Muscular Dystrophy.
Duration: 2000-2001
.
Student: Rosario Calderón.
Career: Biochemistry, P. Universidad Católica de Chile.
Title: Expression and function of heparan sulfate proteoglycans in hippocampal cells: involvement of TGF-???
Duration: 2002-2003.

Student: Rebeca Droguett.
Career: Biochemistry, P. Universidad Católica de Chile.
Title: Two different mechanisms of regulation dependent signaling TGF-? during skeletal muscle differentiation.
Duration: 2003-2004.

Student: Jaime Gutierrez.
Career: Biochemistry, P. Universidad Católica de Chile.
Title: Changes in proteoglycan synthesis during conversion of myoblasts to osteoblasts in response to BMP-2.
Duration: 2004-2005.

Student: Pablo Cañón.
Career: Biochemistry.
Title: LPA participation and stability of the cytoskeleton in the induction of CTGF in muscle cells.
Duration: 2004-2005.

Student: Daniel Cabrera.
Career: Biochemistry, P. Universidad Católica de Chile.
Title: CTGF effect on proteoglycan synthesis in fibroblasts dystrophic.
Duration: 2006-2007.

With Claudio Cabello-Verrugio as Co-adviser
Student: Paula Painemal.
Career: Chemistry and Pharmacy, Universidad de Chile.
Title: Expression control of AT-1 receptor (for angiotensin II) in skeletal muscle.
Duration: 2010-2011.

Student: Camilo Riquelme.
Career: Molecular Biotechnology Engineering, Universidad de Chile.
Title: Interaction myoblast-extracellular matrix mediated by extracelular matrix is required for the expression of CTGF / CCN2.
Duration: 2014-2015.

Student: Juan Pablo Espinoza.
Career: Biotechnology, Universidad Santo Tomás. Santiago.
Title: Effect of SOD1 expression on muscle cells and fibroblasts: role in ALS.
Duration: Enerro 2016-julio 2017.

Professional Training

Student: Francisca Ruiz.
Career: Biochemistry, P. Universidad Católica de Chile.
Title: Isolation of myoblast clones transfected with syndecan-1.
Duration: 1996.

Graduate

Masters in Sciences.

Student: Francisco Melo.
Career: Master in Science, Biochemistry, P. Universidad Católica de Chile.
Title: Differential effect of extracellular matrix in the expression of early and late markers during differentiation of skeletal muscle cells.
Duration: 1993-1994.

Student: María José Villar.
Career: Master in Science, Biochemistry, P. Universidad Católica de Chile.
Title: Characterization of perlecan in myoblasts, association with the cell membrane and its role in cell adhesion processes.
Duration: 1995-1997.

Student: Soledad Cáceres.
Career: Master in Science, Biochemistry, P. Universidad Católica de Chile.
Title: Molecular and biochemical characterization of proteoglycans in mdx skeletal muscle of mice.
Duration: 1997-1999.

PhD Theses in Progress

Student: David Gonzalez.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Role-fibrotic factors and extracellular matrix components in the progression of amyotrophic lateral sclerosis (ALS).
Duration: 2015~2017.

Student: Osvaldo Contreras.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: TCF4 transcription factor and PDGF receptor alpha are key participants in the biology of skeletal muscle: role in myofibroblast differentiation and fibrogenic process triggered by TGF-?.
Duration: 2015~2017.

Student: Roger Valle.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Role of hipoxia in the expression of CTGF/CCN2 in pro-fibrotic cells.
Duration: 2016~2018.

Student: Javier Cerda
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Co-mentoring with Dr. Viviana Montecinos.
Title: Activación de la vía de señalización de VEGF-A en fibroblastos asociados a carcinoma y su papel en la agresividad tumoral en células cancerosas de próstata
Duration: 2017-2019

Student: Mauricio Castro
Career: Ph.D. in Medical Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Co-mentoring with Dr. Verónica Eisner.
Title: Rol de la fibrosis en la pérdida de la fusión mitocondrial del músculo esquelético en la distrofia muscular de Duchenne
Duration: 2017-2019

Completed PhD Theses

Student: Juan Larraín.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Heparan sulfate proteoglycans: Modulators of myogenesis.
Duration: 1995-1998.

Student: Juan Pablo Henríquez.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Identification and Function of Ligand for heparan sulfate proteoglycans During myogenesis.
Duration: 1997-2001.

Student: Cecilia Riquelme.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Modulation of skeletal muscle differentiation by decorina: Effect on TGF-? binding to its receptors.
Duration: 1997-2001.

Student: Hugo Olguín.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Modulation of embryonic myogenesis by proteoglycans.
Duration: 1998-2002.

Student: Nelson Osses.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Effect of extracellular matrix in determining the lineage of mesodermal cells Duration: 1998-2002.

Student: Juan Carlos Casar, M.D.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Participation of proteoglycans in skeletal muscle regeneration in mouse.
Duration: 1999-2003.

Student: Claudia Hurtado.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Biglycan: Participation in skeletal muscle differentiation, modulating the bioavailability of TGF-? and factors that regulate their expression.
Duration: 2002-2005.

Student: Claudio Cabello-Verrugio.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: TGF-? dependent signaling during myogenesis. Participation of decorin and LRP.
Duration: 2004-2007.

Student: Valeria Mezzano, M.D.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: CTGF involvement in skeletal muscle fibrosis.
Duration: 2004-2007.

Student: Cecilia Vial.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: CTGF involvement in skeletal muscle fibrosis during myogenesis and its modulation by proteoglycans.
Duration: 2005-2008.

Student: Rebeca Droguett.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Participation of TGF-? receptors during myogenesis.
Duration: 2006-2009.

Student: Jaime Gutierrez.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Regulation of FGF-2 signaling by Glypican-1 during muscle differentiation.
Duration: 2007-2009.

Student: Daniel Cabrera.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Role of NFkB in skeletal muscle fibrosis induced by exercise.
Duration: 2010-2012.

Student: María Gabriela Morales.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Biological Role of Connective Tissue Growth Factor (CTGF / CCN2) in Skeletal Muscle Fibrosis.
Duration: 2009-2012.

Student: María José Acuña.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Role of the renin-angiotensin system in skeletal muscle fibrosis.
Duration: 2010-2013.

With Pascal Vigey as Co-Adviser
Student: Gozalo Córdova.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile and Doctorat de Biologie Cellulaire et Moléculaire, Université Pierre et Marie Curie, Paris, France.
Title: Role of CTGF and TNF on fibrosis in muscular dystrophy.
Duration: 2011-2014.

Student: Héctor A. Ramirez.
Career: Ph.D. in Biological Sciences, mention in Cell and Molecular Biology, P. Universidad Católica de Chile.
Title: Angiotensina (1-7) promueve la regeneración muscular aumentando la expresión de inos en monocitos pro inflamatorios y promoviendo la expansión de células satélites de forma no dependiente
Duration: 2014-2016.

"Program Science in developing countries".

NATIONAL SCIENCE FOUNDATION

Estados Unidos, 1988

"Program Science in developing countries". Título: Proteoglycan Sulfotransferases.
Howard Hughes International Research Scholar

Howard Hughes Medical Institute

Estados Unidos, 1997

- Howard Hughes International Research Scholar
“Best Teacher”

FEUC

Chile, 1997

Federación Estudiantes (FEUC), P. Universidad Católica de Chile
Presidential Chair in Sciences

Presidencia de la República

Chile, 1998

- Cátedra Presidencial en Ciencias (1998-2000)
- Award for “Best Undergraduate Thesis” Mr. Luis Fuentealba. (Enrique Brandan, Advisor)

Fundación Chilena para la Biología Celular

Chile, 2000

Premio a “La mejor Tesis de Pregrado” Sr. Luis Fuentealba, (Enrique Brandan, Director)
Award for “Best PhD Thesis”. Dr. Juan Larrain (Enrique Brandan, Director)

Fundación Chilena para la Biología Celular

Chile, 2000

Premio a “La mejor Tesis de Doctorado”. Sr. Juan Larraín, (Enrique Brandan, Director)
Howard Hughes International Research Scholar

Howard Hughes Medical Institute

Estados Unidos, 2002

Howard Hughes International Research Scholar
- Member of the Chilean Academy of Sciences

Academia Chilena de Ciencias

Chile, 2008

Miembro Correspondiente de la Academia Chilena de Ciencias
Best Teacher

Federación Estudiantes (FEUC), P. Universidad Católica de Chile

Chile, 2007

“Mejor Profesor”
Recognition Award for Excellence in Teaching, P. Universidad Católica de Chile.

Vice Rectoría Académica, P. Universidad Católica de Chile

Chile, 2007

Premio de Reconocimiento a la Excelencia Docente
Recognition for serving the P. Universidad Católica de Chile for 25 years

P. Universidad Católica de Chile

Chile, 2013

Reconocimiento a los 25 años de servicio a la P. Universidad Católica de Chile
Innovation Award. Copec-UC

Fundación Copec-UC

Chile, 2014

Innovation Award
- Miembro Académico de la Academia de Ciencias de América Latina (ACAL)

Academia de Ciencias de América Latina (ACAL)

Venezuela, 2017

Miembro Académico de la Academia de Ciencias de América Latina (ACAL)


Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle Rivera, Juan Carlos; Abrigo, Johanna; Tacchi, Franco; Simon, Felipe; Brandan, Enrique; Santos, Robson A.; Bader, Michael; Chiong, Mario; Cabello-Verrugio, Claudio Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-? signaling upregulates CCN2/CTGF expression specifically in muscle fibers Valle-Tenney R.; Rebolledo D.L.; Lipson K.E.; Brandan E. Article ISI SCOPUS Matrix Biology (2020)
TGF-beta-driven downregulation of the transcription factor TCF7L2 affects Wnt/beta-catenin signaling in PDGFR alpha(+) fibroblasts Contreras, Osvaldo; Soliman, Hesham; Theret, Marine; Rossi, Fabio M., V; Brandan, Enrique Article ISI JOURNAL OF CELL SCIENCE (2020)
Cross-talk between TGF-beta and PDGFR alpha signaling pathways regulates the fate of stromal fibro-adipogenic progenitors Contreras O.; Cruz-Soca M.; Theret M.; Soliman H.; Tung L.W.; Groppa E.; Rossi F.M.; Brandan E. Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2019)
Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-beta Rebolledo D.L.; GonzÃ¡lez D.; Faundez-Contreras J.; Contreras O.; Vio C.P.; Murphy-Ullrich J.E.; Lipson K.E.; Brandan E. Article ISI SCOPUS MATRIX BIOLOGY (2019)
Denervation-induced skeletal muscle fibrosis is mediated by CTGF/CCN2 independently of TGF-Î². Rebolledo, Daniela L; González, David; Faundez-Contreras, Jennifer; Contreras, Osvaldo; Vio, Carlos P; Murphy-Ullrich, Joanne E; Lipson, Kenneth E; Brandan, Enrique Article Matrix biology => journal of the International Society for Matrix Biology (2019)
Blockade of Bradykinin receptors worsens the dystrophic phenotype of mdx mice: differential effects for B1 and B2 receptors Acuña, María José; Salas, Daniela.; Córdova-Casanova, Adriana; Cruz-Soca, Meilyn; Céspedes, Carlos; Vio, Carlos P; Brandan, Enrique Article ISI SCOPUS Journal of Cell Communication and Signaling (2018)
Blockade of Bradykinin receptors worsens the dystrophic phenotype of mdx mice=> differential effects for B1 and B2 receptors. Acuña, María José; Salas, Daniela; Córdova-Casanova, Adriana; Cruz-Soca, Meilyn; Céspedes, Carlos; Vio, Carlos P; Brandan, Enrique Article Journal of cell communication and signaling (2018)
Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis Riquelme-Guzmán, Camilo; Contreras, Osvaldo; Brandan, Enrique Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2018)
Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis. Riquelme-Guzmán, Camilo; Contreras, Osvaldo; Brandan, Enrique Article American journal of physiology. Cell physiology (2018)
Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation Contreras, Osvaldo; Villarreal, Maximiliano; Brandan, Enrique Article ISI SCOPUS SKELETAL MUSCLE (2018)
Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation. Contreras, Osvaldo; Villarreal, Maximiliano; Brandan, Enrique Article Skeletal muscle (2018)
The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model Gonzalez, D; Rebolledo, DL; Correa, LM; Court, FA; Cerpa, W; Lipson, KE; van Zundert, B; Brandan, E Article ISI SCOPUS HUMAN MOLECULAR GENETICS (2018)
The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model. Gonzalez, David; Rebolledo, Daniela L; Correa, Lina M; Court, Felipe; Cerpa, Waldo; Lipson, Kenneth E; van Zundert, Brigitte; Brandan, Enrique Article Human molecular genetics (2018)
The pro-fibrotic connective tissue growth factor ( CTGF/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle Morales, MG; Acuna, MJ; Cabrera, D; Goldschmeding, R; Brandan, E Article ISI Journal of Cell Communication and Signaling (2018)
The pro-fibrotic connective tissue growth factor (CTGF/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle. Morales, María Gabriela; Acuña, María José; Cabrera, Daniel; Goldschmeding, Roel; Brandan, Enrique Article Journal of cell communication and signaling (2018)
ALS skeletal muscle shows enhanced TGF-beta signaling, fibrosis and induction of fibro/adipogenic progenitor markers Gonzalez, David; Contreras, Osvaldo; Rebolledo, Daniela L.; Espinoza, Juan Pablo; van Zundert, Brigitte; Brandan, Enrique; Asakura, Atsushi Article ISI SCOPUS PLOS ONE (2017)
Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis Cabrera D., Wree A., Povero D., Solís N., Hernandez A., Pizarro M., Moshage, H., Torres, J., Feldstein AE., Cabello-Verrugio C., Brandan E., Barrera F., Arab JP. and Arrese M. Article ISI SCOPUS Scientific Reports (2017)
Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered Contreras, Osvaldo; Brandan, Enrique Article ISI SCOPUS Journal of Cell Communication and Signaling (2017)
The pro-fibrotic connective tissue growth factor (CTGF/CCN2) correlates with the number of necrotic-regenerative foci in dystrophic muscle Morales, María Gabriela; Acuña, María José; Cabrera, Daniel; Goldschmeding, Roel; Brandan, Enrique Article SCOPUS Journal of Cell Communication and Signaling (2017)
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas Morales M.G.; Abrigo, J; Acuna M.J.; Santos R.A.; Bader M.; Brandan, E.; Simon F.; Olguin, H; cabrera, D; Cabello-Verrugio C. Article ISI SCOPUS DMM Disease Models and Mechanisms (2016)
Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis Contreras O.; Rebolledo D.L.; Oyarzún J.E.; Olguín H.C.; Brandan, E. Article ISI SCOPUS Cell and Tissue Research (2016)
Diet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1 Cabrera, Daniel; Ruiz, Alex; Cabello-Verrugio, Claudio; Brandan, Enrique; Estrada, Lisbell; Pizarro, Margarita; Solis, Nancy; Torres, Javiera; Barrera, Francisco; Arrese, Marco Article ISI SCOPUS DIGESTIVE DISEASES AND SCIENCES (2016)
Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy Fuenzalida, M; Espinoza, C.; Perez, MA; Tapia-Rojas, C; Cuitino, L; Brandan, E.; Inestrosa, NC Article ISI SCOPUS NEUROBIOLOGY OF DISEASE (2016)
Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism Cisternas, F.; Morales, MG; Meneses, C.; Simon F.; Brandan, E.; Abrigo, J; Vazquez, Y; Cabello-Verrugio, C Article ISI CLINICAL SCIENCE (2015)
Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism Morales, MG; Olguin, H; Di CApua G; Brandan, E.; Simon F.; Cabello-Verrugio, C Article ISI SCOPUS Clinical Science (2015)
RECK-Mediated beta 1-Integrin Regulation by TGF-beta 1 Is Critical for Wound Contraction in Mice Gutirrez, Jaime; Droppelmann, Cristian A.; Contreras, Osvaldo; Takahashi, Chiaki; Brandan, Enrique; Cukierman, Edna Article ISI SCOPUS PLOS ONE (2015)
SMAD3 and SP1/SP3 Transcription Factors Collaborate to Regulate Connective Tissue Growth Factor Gene Expression in Myoblasts in Response to Transforming Growth Factor Córdova G.; Rochard, A; Riquelme-Guzman, C; Cofré C; Scherman, D; Bigey, P; Brandan, E. Article ISI SCOPUS Journal of Cellular Biochemistry (2015)
The angiotensin-(1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice Meneses, C.; Morales M.; Abrigo, J; Simon F.; Brandan, E.; Cabello-Verrugio, C Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
Transforming growth factor type-beta inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies Cofré C; Acuña MJ; Contreras O.; Morales, MG; Riquelme C.; Cabello-Verrugio, C; Brandan, E. Article ISI SCOPUS BioFactors (2015)
ACE2 Is Augmented in Dystrophic Skeletal Muscle and Plays a Role in Decreasing Associated Fibrosis Riquelme, Cecilia; Acua, Mara Jos; Torrejn, Javiera; Rebolledo, Daniela; Cabrera, Daniel; Santos, Robson A.; Brandan, Enrique; Sampaolesi, Maurilio Article ISI SCOPUS PLOS ONE (2014)
ACE2 is augmented in dystrophic skeletal muscle and plays a role in decreasing associated fibrosis. Riquelme, Cecilia; Acuña, María José; Torrejón, Javiera; Rebolledo, Daniela; Cabrera, Daniel; Santos, Robson A; Brandan, Enrique Article PloS one (2014)
Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis Cabrera, Daniel; Gutiérrez, Jaime; Cabello-Verrugio, Claudio; Morales, Maria; Mezzano, Sergio; Fadic, Ricardo; Casar, Juan; Hancke, Juan L.; Brandan, Enrique Article ISI SCOPUS SKELETAL MUSCLE (2014)
Andrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis. Cabrera, Daniel; Gutiérrez, Jaime; Cabello-Verrugio, Claudio; Morales, Maria Gabriela; Mezzano, Sergio; Fadic, Ricardo; Casar, Juan Carlos; Hancke, Juan L; Brandan, Enrique Article Skeletal muscle (2014)
Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism: effect on migration of skeletal muscle precursor cells Gutierrez J.; cabrera, D; Brandan, E. Article ISI SKELETAL MUSCLE (2014)
Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism=> effect on migration of skeletal muscle precursor cells. Gutiérrez, Jaime; Cabrera, Daniel; Brandan, Enrique Article Skeletal muscle (2014)
Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy Pessina P; cabrera, D; Morales, MG; Riquelme C.; Gutierrez J.; Serrano, AL.; Brandan, E.; Munoz-Canoves, P Article ISI SCOPUS SKELETAL MUSCLE (2014)
Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling Acuña MJ; Pessina P; Olguin, H; cabrera, D; Vio, CP; Bader M.; Munoz-Canoves, P; Santos RA; Cabello-Verrugio, C; Brandan, E. Article ISI HUMAN MOLECULAR GENETICS (2014)
Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-Î² signalling. Acuña, María José; Pessina, Patrizia; Olguin, Hugo; Cabrera, Daniel; Vio, Carlos P; Bader, Michael; Muñoz-Canoves, Pura; Santos, Robson A; Cabello-Verrugio, Claudio; Brandan, Enrique Article Human molecular genetics (2014)
Wnt Signaling in Skeletal Muscle Dynamics: Myogenesis, Neuromuscular Synapse and Fibrosis Cisternas P.; Henriquez, JP; Brandan, E.; Inestrosa, NC Article ISI SCOPUS MOLECULAR NEUROBIOLOGY (2014)
Inhibition of the angiotensin-converting enzyme decreases skeletal muscle fibrosis in dystrophic mice by a diminution in the expression and activity of connective tissue growth factor (CTGF/CCN-2) Morales, MG; cabrera, D; Cespedes, C; Vio, CP; Vazquez, Y; Brandan, E.; Cabello-Verrugio, C Article ISI SCOPUS Cell and Tissue Research (2013)
Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy Calligaris, SD; Lecanda M; Solis, F; Ezquer, M; Gutierrez J.; Brandan, E.; Leiva A.; Sobrevia L.; Conget P. Article ISI SCOPUS PLOS ONE (2013)
Reducing CTGF/CCN2 slows down mdx muscle dystrophy and improves cell therapy Morales, MG; Gutierrez J.; Cabello-Verrugio, C; cabrera, D; Lipson, KE; Goldschmeding, R; Brandan, E. Article ISI SCOPUS Human Molecular Genetics (2013)
Role of proteoglycans in the regulation of the skeletal muscle fibrotic response. Brandan, Enrique; Gutierrez, Jaime Article The FEBS journal (2013)
Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle Painemal P; Acuña MJ; Riquelme C.; Brandan, E.; Cabello-Verrugio, C Article ISI SCOPUS BioFactors (2013)
Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle. Painemal P, Acuña MJ; Riquelme C, Brandan E Article Biofactors (2013)
Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles Cabello-Verrugio, C; Morales M.G.; cabrera, D; Vio C.P.; Brandan, E. Article ISI SCOPUS Journal of Cellular and Molecular Medicine (2012)
Angiotensin II receptor type 1 blockade decreases CTGF/CCN2-mediated damage and fibrosis in normal and dystrophic skeletal muscles. Cabello-Verrugio, Claudio; Morales, María Gabriela; Cabrera, Daniel; Vio, Carlos P; Brandan, Enrique Article Journal of cellular and molecular medicine (2012)
Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells Morales M.G.; Vazquez, Y; Acuna M.J.; Rivera J.C.; Simon F.; Salas J.D.; Alvarez Ruf J; Brandan, E.; Cabello-Verrugio, C Article ISI SCOPUS International Journal of Biochemistry and Cell Biology (2012)
The Internal Region Leucine-rich Repeat 6 of Decorin Interacts with Low Density Lipoprotein Receptor-related Protein-1, Modulates Transforming Growth Factor (TGF)-beta-dependent Signaling, and Inhibits TGF-beta-dependent Fibrotic Response in Skeletal Muscles Cabello-Verrugio, C; Santander C.; Cofré C; Acuna M.J.; Melo F.; Brandan, E. Article ISI SCOPUS Journal of Biological Chemistry (2012)
Connective tissue growth factor induction by lysophosphatidic acid requires transactivation of transforming growth factor type beta receptors and the JNK pathway Cabello-Verrugio, C; Córdova G.; Vial, C; Zuñiga LM; Brandan, E. Article ISI SCOPUS Cellular Signalling (2011)
CTGF/CCN-2 over-expression can directly induce features of skeletal muscle dystrophy Morales, MG; Cabello-Verrugio, C; Santander C.; cabrera, D; Goldschmeding, R; Brandan, E. Article ISI SCOPUS Journal of Pathology (2011)
Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity Vial, C; Gutierrez J.; Santander C.; cabrera, D; Brandan, E. Article ISI SCOPUS Journal of Biological Chemistry (2011)
Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells Cabello-Verrugio, C; Acuña MJ; Morales, MG; Becerra, A; Simon F.; Brandan, E. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2011)
A Novel Mechanism of Sequestering Fibroblast Growth Factor 2 by Glypican in Lipid Rafts, Allowing Skeletal Muscle Differentiation Gutierrez J.; Brandan, E. Article ISI SCOPUS Molecular and Cellular Biology (2010)
Syndecan-4 and beta 1 integrin are regulated by electrical activity in skeletal muscle: Implications for cell adhesion Ugarte, G.; Santander C.; Brandan, E. Article ISI SCOPUS Matrix Biology (2010)
TGF-beta receptors, in a Smad-independent manner, are required for terminal skeletal muscle differentiation Droguett R; Cabello-Verrugio, C; Santander C.; Brandan, E. Article ISI SCOPUS Experimental Cell Research (2010)
Uptake of Tritiated Liquids by Individual Breakfast Cereal Flakes Medina, WT; Laurent S; Brandan, E.; aguilera, jm Article ISI SCOPUS Journal of Food Science (2010)
Inhibition of extracellular matrix assembly induces the expression of osteogenic markers in skeletal muscle cells by a BMP-2 independent mechanism Osses N.; Casar, JC; Brandan, E. Article ISI SCOPUS BMC CELL BIOLOGY (2009)
Matrix Metalloproteinase-2-deficient Fibroblasts Exhibit an Alteration in the Fibrotic Response to Connective Tissue Growth Factor/CCN2 because of an Increase in the Levels of Endogenous Fibronectin Droppelmann, CA; Gutierrez J.; Vial, C; Brandan, E. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy Nguyen TQ; Roestenberg P; van Nieuwenhoven FA; Bovenschen N; Li Z.; Xu, L; Oliver N.; Aten J; Joles JA; Vial, C; Brandan, E.; Lyons KM; Goldschmeding, R Article ISI SCOPUS JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
Heparin activates Wnt signaling for neuronal morphogenesis Colombres M.; Henriquez, JP; Reig, GF; Scheu J.; Calderôn R.; Alvarez A.; Brandan, E.; Inestrosa, NC Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy. Brandan, Enrique; Cabello-Verrugio, Claudio; Vial, Cecilia Article Matrix biology => journal of the International Society for Matrix Biology (2008)
Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation Vial, C; Zuñiga LM; Cabello-Verrugio, C; Canon, P.; Fadic, R; Brandan, E. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2008)
A novel modulatory mechanism of transforming growth factor-ss signaling through decorin and LRP-1 Cabello-Verrugio, C; Brandan, E. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Adenovirus-mediated hepatic syndecan-1 overexpression induces hepatocyte proliferation and hyperlipidaemia in mice Cortés V.; Amigo, L; Donoso K.; Valencia I.; Quiñones V.; Zanlungo S.; Brandan, E.; Rigotti, A. Article ISI SCOPUS LIVER INTERNATIONAL (2007)
Constitutively activated dystrophic muscle fibroblasts show a paradoxical response to TGF-beta and CTGF/CCN2. Mezzano, Valeria; Cabrera, Daniel; Vial, Cecilia; Brandan, Enrique Article Journal of cell communication and signaling (2007)
Betaglycan induces TGF-beta signaling in a ligand-independent manner, through activation of the p38 pathway Santander C.; Brandan, E. Article ISI SCOPUS CELLULAR SIGNALLING (2006)
Changes in secreted and cell associated proteoglycan synthesis during conversion of myoblasts to osteoblasts in response to bone morphogenetic protein-2: Role of decorin in cell response to BMP-2 Gutierrez J.; Osses N.; Brandan, E. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Extracellular proteoglycans modify TGF-beta bio-availability attenuating its signaling during skeletal muscle differentiation Droguett R; Cabello-Verrugio, C; Riquelme C.; Brandan, E. Article ISI SCOPUS MATRIX BIOLOGY (2006)
Increase in decorin and biglycan in Duchenne Muscular Dystrophy: role of fibroblasts as cell source of these proteoglycans in the disease Fadic, R; Mezzano, V; Alvarez, K; cabrera, D; Holmgren, J; Brandan, E. Article ISI SCOPUS JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2006)
Sulfation is required for bone morphogenetic protein 2-dependent Id1 induction Osses N.; Gutierrez J.; Lopez-Rovira, T; Ventura, F; Brandan, E. Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
The low density lipoprotein receptor-related protein functions as an Endocytic receptor for decorin Brandan, E.; Retamal, C; Cabello-Verrugio, C; Marzolo, MP Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Transforming growth factor beta (TGF-beta) signaling is regulated by electrical activity in skeletal muscle cells - TGF-beta type I receptor is transcriptionally regulated by myotube excitability Ugarte, G.; Brandan, E. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway Moreno, M.; Munoz, R.; Aroca, F; Labarca M.; Brandan, E.; Larrain, J Article ISI SCOPUS EMBO JOURNAL (2005)
Caenorhabditis elegans syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva Minniti AN; Labarca M.; Hurtado C.; Brandan, E. Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2004)
Dermatan sulfate exerts an enhanced growth factor response on skeletal muscle satellite cell proliferation and migration Villena J.; Brandan, E. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2004)
Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation Casar, JC; Cabello-Verrugio, C; Olguin, H; Aldunate, R; Inestrosa, NC; Brandan, E. Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2004)
Structural and functional organization of synaptic acetylcholinesterase Aldunate, R; Casar, JC; Brandan, E.; Inestrosa, NC Article ISI BRAIN RESEARCH REVIEWS (2004)
The formation of skeletal muscle myotubes requires functional membrane receptors activated by extracellular ATP Araya, R; Riquelme, MA; Brandan, E.; Sáez JC Article ISI BRAIN RESEARCH REVIEWS (2004)
Transient up-regulation of biglycan during skeletal muscle regeneration: delayed fiber growth along with decorin increase in biglycan-deficient mice Casar, JC; McKechnie, BA; Fallon, JR; Young, MF; Brandan, E. Article ISI SCOPUS DEVELOPMENTAL BIOLOGY (2004)
Betaglycan expression is transcriptionally up-regulated during skeletal muscle differentiation - Cloning of murine betaglycan gene promoter and its modulation by myoD, retinoic acid, and transforming growth factor-beta Lopez-Casillas, F; Riquelme C.; Perez-Kato, Y; Ponce-Castaneda, MV; Osses N.; Esparza-Lopez, J; Gonzalez-Nunez, G; Cabello-Verrugio, C; Mendoza V.; Troncoso, V; Brandan, E. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Inhibition of myoblast migration via decorin expression is critical for normal skeletal muscle differentiation Olguin, HC; Santander C.; Brandan, E. Article ISI SCOPUS DEVELOPMENTAL BIOLOGY (2003)
Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy Alvarez, K; Fadic, R; Brandan, E. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2002)
ECM is required for skeletal muscle differentiation independently of muscle regulatory factor expression Osses N.; Brandan, E. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)
Extracellular matrix histone H1 binds to perlecan, is present in regenerating skeletal muscle and stimulates myoblast proliferation Henriquez, JP; Casar, JC; Fuentealba, L; CAREY, DJ; Brandan, E. Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2002)
Antisense inhibition of decorin expression in myoblasts decreases cell responsiveness to transforming growth factor beta and accelerates skeletal muscle differentiation Riquelme C.; Larrain, J; Schonherr, E; Henriquez, JP; Kresse, H; Brandan, E. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Expression and localization of proteoglycans during limb myogenic activation Olguin, H; Brandan, E. Article ISI DEVELOPMENTAL DYNAMICS (2001)
Postnatal Msx1 expression pattern in craniofacial, axial, and appendicular skeleton of transgenic mice from the first week until the second year Olguin, H; Brandan, E. Article SCOPUS DEVELOPMENTAL DYNAMICS (2001)
Synthesis of proteoglycans is augmented in dystrophic mdx mouse skeletal muscle Caceres, S; Cuellar C.; Casar, JC; Garrido, J.; Schaefer, L.; Kresse, H; Brandan, E. Article ISI SCOPUS EUROPEAN JOURNAL OF CELL BIOLOGY (2000)
Antisense inhibition of syndecan-3 expression during skeletal muscle differentiation accelerates myogenesis through a basic fibroblast growth factor-dependent mechanism. Fuentealba, L; Carey, D J; Brandan, E Article The Journal of biological chemistry (1999)
Interaction of skeletal muscle cells with collagen type IV is mediated by perlecan associated with the cell surface. Villar, M J; Hassell, J R; Brandan, E Article Journal of cellular biochemistry (1999)
Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type I collagen. Schönherr, E; Broszat, M; Brandan, E; Bruckner, P; Kresse, H Article Archives of biochemistry and biophysics (1998)
Syndecan-1 expression inhibits myoblast differentiation through a basic fibroblast growth factor-dependent mechanism. Larraín, J; Carey, D J; Brandan, E Article The Journal of biological chemistry (1998)
Ethodin=> pharmacological evidence of the interaction between smooth muscle and mast cells in the myometrium. Rudolph, M I; de los Angeles García, M; Sepulveda, M; Brandan, E; Reinicke, K; Nicovani, S; Villan, L Article The Journal of pharmacology and experimental therapeutics (1997)
Expression of perlecan, a proteoglycan that binds myogenic inhibitory basic fibroblast growth factor, is down regulated during skeletal muscle differentiation. Larraín, J; Alvarez, J; Hassell, J R; Brandan, E Article Experimental cell research (1997)
Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix=> evidence for the participation of heparan sulfate proteoglycans. Cáceres, J; Brandan, E Article Journal of cellular biochemistry (1997)
Syndecan-1 expression is down-regulated during myoblast terminal differentiation. Modulation by growth factors and retinoic acid. Larraín, J; Cizmeci-Smith, G; Troncoso, V; Stahl, R C; Carey, D J; Brandan, E Article The Journal of biological chemistry (1997)
Extracellular matrix is required for skeletal muscle differentiation but not myogenin expression. Melo, F; Carey, D J; Brandan, E Article Journal of cellular biochemistry (1996)
Significantly reduced expression of the proteoglycan decorin in Alzheimer's disease fibroblasts. Brandan, E; Melo, F; García, M; Contreras, M Article Clinical molecular pathology (1996)
Synthesis and processing of glypican during differentiation of skeletal muscle cells. Brandan, E; Carey, D J; Larraín, J; Melo, F; Campos, A Article European journal of cell biology (1996)
Differentiation of oxyntic cells and cell-matrix interactions during avian gastric gland morphogenesis. Koenig, C S; Dabike, M; Nuñez, R; Munizaga, A; Brandan, E; Garrido, J Article Biological research (1994)
Proteoglycans in skeletal muscle. Brandan, E Article Brazilian journal of medical and biological research = Revista brasileira de pesquisas mÃ©dicas e biolÃ³gicas / Sociedade Brasileira de BiofÃsica ... [et al.] (1994)
A lipid-anchored heparan sulfate proteoglycan is present in the surface of differentiated skeletal muscle cells. Isolation and biochemical characterization. Campos, A; Núñez, R; Koenig, C S; Carey, D J; Brandan, E Article European journal of biochemistry / FEBS (1993)
Decorin is specifically solubilized by heparin from the extracellular matrix of rat skeletal muscles. Melo, F; Brandan, E Article FEBS letters (1993)
Extracellular matrix components and amyloid in neuritic plaques of Alzheimer's disease. Brandan, E; Inestrosa, N C Article General pharmacology (1993)
Isolation and partial characterization of cholesterol pronucleating hydrophobic glycoproteins associated to native biliary vesicles. Miquel, J F; Núñez, L; Rigotti, A; Amigo, L; Brandan, E; Nervi, F Article FEBS letters (1993)
A high molecular weight proteoglycan is differentially expressed during development of the mollusc Concholepas concholepas (Mollusca; Gastropoda; Muricidae). Brandan, E; González, M; Inestrosa, N C; Tremblay, C; Urrea, R Article The Journal of experimental zoology (1992)
Axonal sprouting induced in the sciatic nerve by the amyloid precursor protein (APP) and other antiproteases. Alvarez, J; Moreno, R D; Llanos, O; Inestrosa, N C; Brandan, E; Colby, T; Esch, F S Article Neuroscience letters (1992)
Decorin, a chondroitin/dermatan sulfate proteoglycan is under neural control in rat skeletal muscle. Brandan, E; Fuentes, M E; Andrade, W Article Journal of neuroscience research (1992)
Isolation and purification of human biliary vesicles with potent cholesterol-nucleation-promoting activity. Miquel, J F; Rigotti, A; Rojas, E; Brandan, E; Nervi, F Article Clinical science (London, England => 1979) (1992)
Isolation of proteoglycans synthesized by rat heart=> evidence for the presence of several distinct forms. Gonzalez, R; Urrea, R; Gonzalez, M; Inestrosa, N C; Brandan, E Article General pharmacology (1992)
Isolation and characterization of rat skeletal muscle proteoglycan decorin and comparison with the human fibroblast decorin. Andrade, W; Brandan, E Article Comparative biochemistry and physiology. B, Comparative biochemistry (1991)
The proteoglycan decorin is synthesized and secreted by differentiated myotubes. Brandan, E; Fuentes, M E; Andrade, W Article European journal of cell biology (1991)
[Biotechnological aspects in "loco" larvae]. Inestrosa, N C; Labarca, R; Perelman, A; Campos, E O; Araneda, R; González, M; Brandan, E; Sánchez, J P; González-Plaza, R Article Archivos de biologÃa y medicina experimentales (1990)
Differential association and distribution of acetyl- and butyrylcholinesterases within rat liver subcellular organelles. Perelman, A; Abeijon, C; Hirschberg, C B; Inestrosa, N C; Brandan, E Article The Journal of biological chemistry (1990)
Motor nerve regulates muscle extracellular matrix proteoglycan expression. Fadic, R; Brandan, E; Inestrosa, N C Article The Journal of neuroscience => the official journal of the Society for Neuroscience (1990)
Different membrane-bound forms of acetylcholinesterase are present at the cell surface of hepatocytes. Perelman, A; Brandan, E Article European journal of biochemistry / FEBS (1989)
Differential association of rat liver heparan sulfate proteoglycans in membranes of the Golgi apparatus and the plasma membrane. Brandan, E; Hirschberg, C B Article The Journal of biological chemistry (1989)
Purification of rat liver N-heparan-sulfate sulfotransferase. Brandan, E; Hirschberg, C B Article The Journal of biological chemistry (1988)
Co-solubilization of asymmetric acetylcholinesterase and dermatan sulfate proteoglycan from the extracellular matrix of rat skeletal muscles. Brandan, E; Inestrosa, N C Article FEBS letters (1987)
Glycosaminoglycan composition of electric organ basement membranes. Inestrosa, N C; Nader, H B; Garrido, J; Sampaio, L O; Brandan, E; Dietrich, C P Article Journal of neuroscience research (1987)
Isolation of the heparan sulfate proteoglycans from the extracellular matrix of rat skeletal muscle. Brandan, E; Inestrosa, N C Article Journal of neurobiology (1987)
Heparin-acetylcholinesterase interaction=> Specific detachment of class I-A forms and binding of class I and II-A forms to heparin-agarose. Brandan, E; Llona, I; Inestrosa, N C Article Neurochemistry international (1986)
The synaptic form of acetylcholinesterase binds to cell-surface heparan sulfate proteoglycans. Brandan, E; Inestrosa, N C Article Journal of neuroscience research (1986)
Anchorage of collagen-tailed acetylcholinesterase to the extracellular matrix is mediated by heparan sulfate proteoglycans. Brandan, E; Maldonado, M; Garrido, J; Inestrosa, N C Article The Journal of cell biology (1985)
Binding of the asymmetric forms of acetylcholinesterase to heparin. Brandan, E; Inestrosa, N C Article The Biochemical journal (1984)
Isolation and characterization of coated vesicles from rat liver. Simion, F A; Winek, D; Brandan, E; Fleischer, B; Fleischer, S Article Methods in enzymology (1983)
Golgi complex function in the excretion of renal kallikrein (41502). Brandan, E; Rojas, M; Loyarte, N; Zambrano, F Article Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) (1982)
Orientation and role of nucleosidediphosphatase and 5'-nucleotidase in Golgi vesicles from rat liver. Brandan, E; Fleischer, B Article Biochemistry (1982)
Subcellular fractionation studies on the organization of fatty acid oxidation by liver peroxisomes. Leighton, F; Brandan, E; Lazo, O; Bronfman, M Article Annals of the New York Academy of Sciences (1982)
Salt loading effect on renal kallikrein activity in rat. Rojas, M; Brandan, E; Zambrano, F Article Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) (1980)
Increase in decorin and biglycan in Duchenne Muscular Dystrophy=> role of fibroblasts as cell source of these proteoglycans in the disease. Fadic, Ricardo; Mezzano, Valeria; Alvarez, Karin; Cabrera, Daniel; Holmgren, Jenny; Brandan, Enrique Article Journal of cellular and molecular medicine (0)
Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle. Painemal, Paula; Acuña, María José; Riquelme, Cecilia; Brandan, Enrique; Cabello-Verrugio, Claudio Article BioFactors (Oxford, England) (0)


NFkB inhibition by Andrographolide ameliorates inflammation and fibrogenesis through inflammasome substrate depletion in experimental Non-Alcoholic Steatohepatitis (NASH) cabrera, D; Wree, A; Povero, D; Solís N.; Pizarro M.; de Santiago, PR; Torres J.; Moshage, H; Cabello-Verrugio, C; Feldstein, AE; Brandan, E.; Arrese M. Abstract ISI HEPATOLOGY (2015)
Diet-induced nonalcoholic fatty liver disease is associated with sarcopenia and decreased serum insulin growth factor-1 Ruiz A.; cabrera, D; Quintero, P.; Pizarro M.; Solís N.; Torres J.; Cabello-Verrugio, C; Brandan, E.; Barrera F.; Arrese M. Abstract ISI HEPATOLOGY (2014)
Lipopolysaccharide-induced skeletal muscle atrophy is prevented by Angiotensin (1-7) via Mas receptor. Morales, MG; Olguin, HH; Brandan, E.; Simon F.; Cabello-Verrugio, C Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2014)
Effects of andrographolide in experimental non-alcoholic steatohepatitis cabrera, D; Pizarro M.; Solís N.; Torres J.; Brandan, E.; Arrese M. Abstract ISI HEPATOLOGY (2013)
Human platelet activation/secretion and a membrane-associated urokinase-like activity induce the activation of the latent form of platelet transforming growth factor-beta 1 (TGF-beta 1) Panes O.; Gutierrez J.; Iruretagoyena M.; Brandan, E.; Mezzano D. Abstract ISI JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2013)


Analysis of Pathological Activities of CCN2/CTGF in Muscle Dystrophy Acuña M.J.; Brandan E. BookWhole ISI SCOPUS NEISSERIA MENINGITIDIS (2017)


Heparan sulfate provides a mechanism to respond to FGFR2b and control regenerative expansion Brandan, E. EditorialMaterial ISI SCOPUS Journal of Cell Communication and Signaling (2015)


Transforming growth factor type- inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies (vol 42, pg 111, 2015) Cofré C; Acuña MJ; Contreras O.; Morales, MG; Riquelme C.; Bader M.; Santos R.; Cabello-Verrugio, C; Brandan, E. Errata ISI SCOPUS BioFactors (2015)


Methods for Treatment Motor Neuron Diseases Brandan, Enrique; David Gonzalez Patent PCT (2015)
1. Methods for Treatment of Muscular Dystrophy. Estados Unidos Brandan, Enrique; Goldschmeding, Roel; Oliver, N. Patent Jul. 8, 2014 (2014)
Pharmaceutical compositions containing the agonist of receptor Mas for the treatment of degenerative muscle diseases. Brandan Enrique y 17 mas Patent 31.10.2012 (2012)
Pharmaco-Cellular Therapeutic Method for the Treatment of Muscular Dystrophies Brandan Enrique y 5 mas Patent Sep. 18, 2014


Participation of mesenchymal progenitors in the initiation of skeletal muscle fibrosis: Effect of TGFβ/CTGF/PDGF and cofactors on fibroblasts’ ability to modulate myogenesis Brandan E, Proyecto (2015)
Novel Antifibrotic Role of the ACE2/Angiotensin 1-7/Mas Axis in Skeletal Muscular Dystrophies Brandan E, Proyecto (2011)
Centro de Envejecimiento y Regeneración (CARE) Brandan E,; Total Siete investigadores Proyecto (2008)
CTGF the factor involved in fibrosis development in DMD Brandan E, Proyecto (2008)
Droga Botánica para el tratamiento de enfermedades crónicas asociadas con fibrosis y de alta incidencia Brandan E, Proyecto (2008)
Skeletal muscle formation, function and disease. Brandan E,; más cuatro investigadores Proyecto (2005)
DMD fibrosis: Role of CTGF, LRP and proteoglycans Brandan E, Proyecto (2004)
Skeletal muscle formation, function and disease Brandan E,; mas cuatro investigadores Proyecto (2000)
Biological Function of Proteoglycans during Myogenesis Brandan E, Proyecto (1998)
Function of proteoglycans during skeletal muscle differentiation Brandan E, Proyecto (1997)
Decorin as a modulator of TGF-beta activity on skeletal muscle differentiation Brandan E,; Hans Kresse Proyecto (1996)
Function heparan sulfate proteoglycans during myogenesis Brandan E, Proyecto (1996)
Papel de los proteoglicanes en la formación de la placa neurítica, el crecimiento neuronal y el eventual diagnóstico de la enfermedad de Alzheimer Brandan E, Proyecto (1993)
Role of the proteoglycans in the organization of the extracellular matrix and their effect on skeletal muscle differentiation. Brandan E, Proyecto (1993)
Skeletal Muscle hydrophobic Proteoglycans Brandan E,; David J. Carey Proyecto (1993)
Biochemicals factors that control sulphation in muscle cells. Brandan E, Proyecto (1989)
Expression and regulation of proteoglycans of the extracellular matrix of muscle and evaluation in skeletal muscle disorders. Brandan E, Proyecto (1989)
Proteoglycan Sulfotransferases. Brandan E,; Carlos Hirschberg Proyecto (1988)
Millennium Institute for Fundamental and Applied Biology Brandan E,; 11 investigadores Proyecto (0)


HIF-hypoxia signaling in skeletal muscle physiology and fibrosis Valle-Tenney R.; Rebolledo D.; AcuÃ±a M.J.; Brandan E. Review ISI SCOPUS Journal of Cell Communication and Signaling (2020)
CTGF/CCN2 from Skeletal Muscle to Nervous System: Impact on Neurodegenerative Diseases Gonzalez D.; Brandan E. Review ISI SCOPUS MOLECULAR NEUROBIOLOGY (2019)
Angiotensins as therapeutic targets beyond heart disease Passos-Silva, DG; Brandan, E.; Santos RAS Review ISI SCOPUS Trends in Pharmacological Sciences (2015)
Role of proteoglycans in the regulation of the skeletal muscle fibrotic response Brandan, E.; Gutierrez J. Review ISI SCOPUS FEBS Journal (2013)
Role of skeletal muscle proteoglycans during myogenesis Brandan, E.; Gutierrez J. Review ISI SCOPUS Matrix Biology (2013)
Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy Brandan, E.; Cabello-Verrugio, C; Vial, C Review ISI MATRIX BIOLOGY (2008)

123

Enrique Brandan

Profesor Titular

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Daniel Cabrera

Investigador Adjunto

Gastroenterología

Pontificia Universidad Catolica de Chile

santiago, Chile

Jaime Gutierrez

Associate Professor and Researcher

Tecnología Médica

Universidad San Sebastián

Santiago, Chile

María Acuña

Directora de Investigación, académico e investigador

Universidad Bernardo O´Higgins

Santiago, Chile

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Nelson Osses

Associated Professor

Institute of Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

Daniela Rebolledo

Académico

Centro de Excelencia en Biomedicina de Magallanes

Punta Arenas, Chile

Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Hugo Olguin

Profesor Asociado

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

JUAN PABLO HENRIQUEZ

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

ricardo fadic

Jefe de Division

Division de Neurociencias

DEPARTAMENTO DE NEUROLOGÍA, FACULTAD DE MEDICINA, P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

David González

Investigador postdoctoral

Institut des Neurosciences de Montpellier (INM)

Montpellier, Francia

Margarita Pizarro

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Johanna Ábrigo

Bioquímico

Centro de Bioinformática y Biología Integrativa

Santiago, Chile

Osvaldo Contreras

Yaneisi Vazquez

Directora técnica de proyectos

Genética Molecular

Pontificia Universidad Católica de Chile

Santiago, Chile

Rebeca Aldunate

Profesor Titular

Ciencias

UNIVERSIDAD SANTO TOMÁS

Santiago, Chile

JUAN VILLENA

FULL PROFESSOR

ANATOMY

FACULTA DE MEDICINA. UNIVERSIDAD DE VALPARAISO

VIÑA DEL MAR, Chile

Francisco Melo

Profesor Titular

Genetica Molecular y Microbiologia

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Silvana Zanlungo

Full Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

Gonzalo Ugarte

Asistente de Investigación

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Juan Agustín Larraín

Profesor Titular

Biologia Celular y Molecular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Olga Panes

Technical Director/ Associated Research

Hematology-Oncology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Maria Paz Marzolo

Profesor Titular

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Pedro Cisternas

Investigador Asociado

Biología Celular

Pontificia Universidad Católica de Chile

Santiago, Chile

Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

Victor Cortes

Associate professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

Sebastián Calligaris

Cordinador de Estudios Clínicos

Clínica Alemana

Santiago, Chile

Alicia Nogueras

Profesor Asociado Adjunto

Departamento de Biología Celular y Molecular

P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Brigitte van Zundert

Full Professor

UNIVERSIDAD ANDRÉS BELLO, CENTRO DE INVESTIGACIONES BIOMÉDICAS

Santiago, Chile

Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

Daniela Salas

Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

Sergio Mezzano

Catedratico

Medicina

Universidad Austral de Chile

Valdivia, Chile

Francisco Barrera

Profesor Asociado

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

Rosana Muñoz

postdoctorante

UNIVERSIDAD DE CHILE

Santiago, Chile

Juan Oyarzún

Investigador postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

Juan Rivera

Investigador

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

Loreto Cuitiño

Investigador Asociado

Oftalmología

Hospital Clínico Universidad de Chile

229788866, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Pablo Cañón

Académico Regular

Escuela de Agronomía

Universidad Mayor de Chile

Santiago, Chile

Juan Espinoza

Encargado de Cultivo Celular y Bioterio

Universidad Bernardo O'Higgins

Santiago, Chile

MIGUEL PEREZ

Associate Professor

Pontificia Universidad Catolica de Valparaiso

VALPARAISO, Chile

Enrique Brandan Siques

Líneas de Investigación

Educación

Cell Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1985

Biology, UNIVERSIDAD DE CHILE. Chile, 1979

Experiencia Académica

Research Assistant Full Time

PostDoctoral Fellow Full Time

Postdoctoral fellow Full Time

Assistant Professor Full Time

Associate Professor Full Time

Full Professor Full Time

Full Professor Full Time

Experiencia Profesional

Research Associate Full Time

Visiting Assistant Research Professor Full Time

Assistant Professor Full Time

Profesor Asistente Full Time

Profesor Asociado Full Time

Profesor Titular Full Time

Profesor/Investigador Full Time

Formación de Capital Humano

Premios y Distinciones

"Program Science in developing countries".

Howard Hughes International Research Scholar

“Best Teacher”

Presidential Chair in Sciences

- Award for “Best Undergraduate Thesis” Mr. Luis Fuentealba. (Enrique Brandan, Advisor)

Award for “Best PhD Thesis”. Dr. Juan Larrain (Enrique Brandan, Director)

Howard Hughes International Research Scholar

- Member of the Chilean Academy of Sciences

Best Teacher

Recognition Award for Excellence in Teaching, P. Universidad Católica de Chile.

Recognition for serving the P. Universidad Católica de Chile for 25 years

Innovation Award. Copec-UC

- Miembro Académico de la Academia de Ciencias de América Latina (ACAL)

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