Man

Juan Carlos Sáez Carreño

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


immunology; cell death; cellular biology; neurobiology; cellular communication


Tipos de Producción
 

Dtp Import/Article (85)

Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels=> A neuroprotective mechanism.
Connexin-Dependent Neuroglial Networking as a New Therapeutic Target.
Connexins and Pannexins in Bone and Skeletal Muscle.
Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease
On Biophysical Properties and Sensitivity to Gap Junction Blockers of Connexin 39 Hemichannels Expressed in HeLa Cells.
Regulation of Connexin-Based Channels by Fatty Acids.
A Soluble Activin Receptor IIB Fails to Prevent Muscle Atrophy in a Mouse Model of Spinal Cord Injury.
Connexin hemichannels explain the ionic imbalance and lead to atrophy in denervated skeletal muscles.
Connexin Hemichannels=> Methods for Dye Uptake and Leakage.
Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels.
Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels.
Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis.
High glucocorticoid levels during gestation activate the inflammasome in hippocampal oligodendrocytes of the offspring.
Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism.
The absence of dysferlin induces the expression of functional connexin-based hemichannels in human myotubes.
Connexin43 hemichannels mediate secondary cellular damage spread from the trauma zone to distal zones in astrocyte monolayers.
Hemichannels Are Required for Amyloid β-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice.
Keratitis-Ichthyosis-Deafness Syndrome-Associated Cx26 Mutants Produce Nonfunctional Gap Junctions but Hyperactive Hemichannels When Co-Expressed With Wild Type Cx43.
Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells.
Pannexin channels mediate the acquisition of myogenic commitment in C2C12 reserve cells promoted by P2 receptor activation.
Regulation of pannexin and connexin channels and their functional role in skeletal muscles.
Restraint stress increases hemichannel activity in hippocampal glial cells and neurons.
Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition.
Characterization of a novel water pocket inside the human Cx26 hemichannel structure.
Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca(2+) signaling in HeLa cells.
HIV increases the release of dickkopf-1 protein from human astrocytes by a Cx43 hemichannel-dependent mechanism.
Hunting for connexin hemichannels.
Neuronal involvement in muscular atrophy.
Opening of pannexin- and connexin-based channels increases the excitability of nodose ganglion sensory neurons.
Pannexin 1 channels in skeletal muscles.
Pannexin 1 channels: new actors in the regulation of catecholamine release from adrenal chromaffin cells.
Pannexin 1 regulates bidirectional hippocampal synaptic plasticity in adult mice
Pannexin1 channels act downstream of P2X 7 receptors in ATP-induced murine T-cell death.
Regulation of hemichannels and gap junction channels by cytokines in antigen-presenting cells.
ATP is required and advances cytokine-induced gap junction formation in microglia in vitro.
Boldine prevents renal alterations in diabetic rats.
Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia.
Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles.
De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy.
Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels.
Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels.
Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice.
FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and P2X7 receptors.
Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress.
Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca2+-dependent pathway.
Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes.
Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes.
Possible involvement of TLRs and hemichannels in stress-induced CNS dysfunction via mastocytes, and glia activation.
Role of gap junctions and hemichannels in parasitic infections.
The extracellular ATP required for potentiation of the adult skeletal muscle contraction is released through pannexin 1 based channels
Connexin 36 is expressed in beta and connexins 26 and 32 in acinar cells at the end of the secondary transition of mouse pancreatic development and increase during fetal and perinatal life.
Connexin and pannexin hemichannels in inflammatory responses of glia and neurons.
Connexin- and pannexin-based channels in normal skeletal muscles and their possible role in muscle atrophy.
Connexin-based channels in astrocytes: how to study their properties.
Connexins 26, 32 and 36 are expressed in a cell-specific manner at the end of the secondary transition of fetal mouse pancreas development and increase during fetal and perinatal life.
Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function.
Glial connexin expression and function in the context of Alzheimer's disease.
Glial hemichannels and their involvement in aging and neurodegenerative diseases.
Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels
Modulation of gap junction channels and hemichannels by growth factors.
Permeation of calcium through purified connexin 26 hemichannels.
Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels.
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdal
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala.
The role of gap junction channels during physiologic and pathologic conditions of the human nervous system.
ATP and glutamate hemichannels mediate neuronal death through released via astroglial connexin 43 activation of pannexin 1 hemichannels.
Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species
FGF -1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels.
Hemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions.
Cell membrane permeabilization via connexin-hemichannels in living and dying cells.
Connexin43 is a pH-gated plasma membrane calcium channel.
Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels.
Inhibition of Cx43 hemichannels activated by pro-inflammatory treatment exhibited a neuroprotective effect against NMDA excitotocixity.
ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle.
Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments.
Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases.
Gap junctions at the dendritic cell-T cell Interface are key elements for antigen-dependent T cells activation.
Metabolic inhibition increases the activity of connexin-32 hemichannels which are permeable to Ca2+
Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neuro-egeneration.
Astrocytes as connexin-dependent signaling cells for local blood flow regulation.
Currently used methods for identification and characterization of hemichannels
Functional role of gap junctions in cytokine-induced leukocyte adhesion and transmigration in vivo.
The connexin hemichannel composition determines the FGF-1-induced membrane permeability and free Ca2+i responses.
Biological mechanisms involved in the spread of traumatic brain damage.
Sepsis-Induced Channelopathy in Skeletal Muscles is Associated with Expression of Non-Selective Channels.

Article (23)

Angiotensin II-Induced Mesangial Cell Damage Is Preceded by Cell Membrane Permeabilization Due to Upregulation of Non-Selective Channels
Role of calcium permeable channels in dendritic cell migration
Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes
ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X(7) receptors
Connexins and pannexins in Alzheimer's disease
Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease
Sepsis-Induced Channelopathy in Skeletal Muscles is Associated with Expression of Non-Selective Channels
A soluble activin receptor IIB fails to prevent muscle atrophy in a mouse model of spinal cord injury
Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis
Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism
Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells
Extracellular gentamicin reduces the activity of con nexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells
Gap Junction Intercellular Communication Mediated by Connexin43 in Astrocytes Is Essential for Their Resistance to Oxidative Stress
Connexin 36 is Expressed in Beta and Connexins 26 and 32 in Acinar Cells at the End of the Secondary Transition of Mouse Pancreatic Development and Increase During Fetal and Perinatal Life
Connexin-based channels in astrocytes: How to study their properties
Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function
Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels
Permeation of Calcium through Purified Connexin 26 Hemichannels
Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala
Boldina disminuye la apoptosis miocárdica post isquemia reperfusión en la rata
TNF-? plus IFN-? induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses
Activation of human polymorphonuclear cells induces formation of functional gap junctions and expression of connexins

Review (8)

Role of astrocyte connexin hemichannels in cortical spreading depression
Connexin-Dependent Neuroglial Networking as a New Therapeutic Target
Connexins and Pannexins in Bone and Skeletal Muscle
Biological mechanisms involved in the spread of traumatic brain damage
Connexin and pannexin hemichannels in inflammatory responses of glia and neurons
Connexin- and Pannexin-Based Channels in Normal Skeletal Muscles and Their Possible Role in Muscle Atrophy
Glial connexin expression and function in the context of Alzheimer's disease
Modulation of gap junction channels and hemichannels by growth factors

Abstract (2)

HIV infection of astrocytes increases release of Dickkopf-1 protein by a gap junction and hemichannel dependent mechanism
Specific ablation of connexin 43 delays skeletal muscle regeneration in vivo

Grant (2)

Book Whole (1)

Connexin and Pannexin Based Channels in the Nervous System: Gap Junctions and More
36
Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

17
Juan Saez

Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

7
Juan Orellana

Assistant Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

5
Vania Figueroa

Profesor Asistente

Instituto de Ciencias de la Salud

Universidad de O’Higgins

Rancagua, Chile

4
Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

4
Jose Luis Vega

Profesor Asociado

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

3
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

3
Carlos Puebla

Profesor Asistente

Universidad Autónoma de Chile

Santiago, Chile

2
Mauricio Retamal

Profesor Asociado

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

2
Rommy Von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Marlene Arismendi

INVESTIGADOR JEFE

INVESTIGACION Y DESARROLLO

NANOTEC S.A

SANTIAGO, Chile

1
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

1
CARLOS LAGOS

Profesor Asistente

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1
Maria Garcia

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Fernando Delgado

Associate Professor

Division of Medicine

Universidad Catolica del Maule

Talca, Chile

1
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

1
Isaac Garcia

Profesor Adjunto

Instituto de Neurociencias

Universidad de Valparaiso

Valparaiso, Chile

1
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
HELMUTH SANCHEZ

INVESTIGADOR JOVEN

Laboratorio de Conexinas y Panexinas

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAISO

VALPARAISO, Chile

1
Roberto Elizondo

Investigador Post-Doctoral

Universidad de los Andes

Santiago, Chile

1
David Rovegno

PROFESOR ASISTENTE ADJUNTO

Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Francisco Nualart

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile