Man

Mauricio Antonio Retamal Lucero

Profesor Asociado

Universidad del Desarrollo

Santiago, Chile

Líneas de Investigación


Estudio de los mecanismos moleculares de apertura y cierre de los canales formados por conexinas. Y el estudio de los hemicanales en diversas funciones celulares en condiciones fisiológicas y patológicas.

Educación

  •  Doctor, Universidad Catolica de Chile. Chile, 2005
  •  Licenciado, Universidad de Chile. Chile, 2000
  •  PhD en Fisiologia, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Experiencia Académica

  •   Profesor Asociado Full Time

    Universidad del Desarrollo

    Medicina

    santiago, Chile

    Enero 2008 - A la fecha


Tipos de Producción
 

Article (24)

Extracellular Cysteine in Connexins: Role as Redox Sensors
Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness
Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases
Functional hemichannels formed by human connexin 26 expressed in bacteria
Neuron-Glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis
Carbon Monoxide (CO) Is a Novel Inhibitor of Connexin Hemichannels
Connexin and Pannexin hemichannels are regulated by redox potential
Extracellular gentamicin reduces the activity of con nexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells
Hemichannels; from the molecule to the function
Petrosal ganglion: a more complex role than originally imagined
Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation
Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca2+-dependent pathway
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala
Biphasic effect of linoleic acid on connexin 46 hemichannels
FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels
Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity
Voltage-dependent facilitation of Cx46 hemichannels
Modulation of Cx46 hemichannels by nitric oxide
Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+](i) responses
Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia
Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential
S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents
Dopamine inhibits ATP-induced responses in the cat petrosal ganglion in vitro
Adenosine triphosphate-induced peripheral nerve discharges generated from the cat petrosal ganglion in vitro

Dtp Import/Article (18)

Regulation of Connexin-Based Channels by Fatty Acids.
Carbon Monoxide Modulates Connexin Function through a Lipid Peroxidation-Dependent Process: A Hypothesis.
Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins.
Connexinopathies: a structural and functional glimpse.
Regulation of Connexins Expression Levels by MicroRNAs, an Update.
Regulation of gap junction channels and hemichannels by phosphorylation and redox changes: a revision.
Carbon monoxide: A new player in the redox regulation of connexin hemichannels.
Diseases associated with leaky hemichannels
Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals.
Opening of pannexin and connexin based-channels increases the excitability of nodose ganglion sensory neurons.
ATP is required and advances cytokine-induced gap junction formation in microglia in vitro.
Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules.
Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: Gap junctions versus hemichannels
Nitric oxide signaling in the retina: What have we learned in two decades?
Cell membrane permeabilization via connexin hemichannels in living and dying cells
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion
Connexin-based gap junction hemichannels: gating mechanisms
Gap junction hemichannels in astrocytes of the CNS

Review (7)

Carbon monoxide: A new player in the redox regulation of connexin hemichannels
Diseases associated with leaky hemichannels
Nitric oxide signaling in the retina: What have we learned in two decades?
Cell membrane permeabilization via connexin hemichannels in living and dying cells
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion
Connexin-based gap junction hemichannels: Gating mechanisms
Gap junction hemichannels in astrocytes of the CNS

Grant (6)

Beca Doctorado - Conicyt
Sensor de Voltage de Canales de Iones: Desde la Estructura a la Función

Abstract (5)

Linolenic and Linoleic Acid Induce the Opening of Connexin 43, 46 and 50 Hemichannel in Human Hela Cells
Purified Functional Human Connexin 26 Hemichannels Expressed in E. Coli
Is the Gain of Hemichannel Activity a Common Feature Shared by Cx26 Syndromic Deafness Mutants?
Hemichannels formed by connexin43 are sensitive to changes in cellular redox potential
Studies on putative gating mechanisms involved in opening Cx43 hemichannels in metabolically inhibited rat astrocytes

Editorial Material (1)

Ion Channels in Inflammatory Processes: What Is Known and What Is Next?

Errata (1)

Dopamine inhibits ATP-induced responses in the cat petrosal ganglion in vitro (vol 966, pg 283, 2003)
55
Mauricio Retamal

Profesor Asociado

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

15
Juan Saez

Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

7
Juan Orellana

Assistant Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Vania Figueroa

Profesor Asistente

Instituto de Ciencias de la Salud

Universidad de O’Higgins

Rancagua, Chile

4
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

3
Julio Alcayaga

UNIVERSIDAD DE CHILE, FAC. CIENCIAS, DEPTO. BIOLOGÍA

Santiago, Chile

2
Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Marcelo Ezquer

Director/Profesor asociado

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

1
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

1
Carlos Manuel González

DIRECTOR ESCUELA

FACULTAD CIENCIAS DE LA VIDA

UNIVERSIDAD ANDRES BELLO

SANTIAGO, Chile

1
Fernando Ezquer

Profesor Asociado

Centro de Medicina Regenerativa

Universidad del Desarrollo

Santiago, Chile

1
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

1
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

1
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

1
Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile