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Mauricio Antonio Retamal Lucero

Associate Professor

Universidad del Desarrollo

Santiago, Chile

Study of the molecular mechanisms of opening and closing of the channels formed by connexins. And the study of hemichannels in various cellular functions under physiological and pathological conditions.

Bachelor of Science / Biology, UNIVERSIDAD DE CHILE. Chile, 2000
PhD in Physiology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Associate Professsor Full Time

Universidad del Desarrollo

Medicina

santiago, Chile

2008 - A la fecha

Postdoctoral Tutor training of Dr. Rodrigo Acuña. 2016-2020.
Tutor of PhD student. Ms Fernanda Rozas. 2016-present.
Tutor of PhD student Ms Viviana Orellana. 2017-present.
Tutor of PhD student Ms Ainoa Fernandez. 2019-present.

Classes in General Physiology for Medicine - UDD
Classes of Advanced Topics in Physiology - DICIM
Class on cellular communication in Biomedical Sciences - U. Autónoma
In all these courses, I have told students about connexins, hemichannels, cleft junctions, and lab results.

In 2018, I participated in the science week of the Alianza Francesa school, Chamisero headquarters. On that occasion, during one morning I talked to kindergarteners about science and also did a series of basic experiments on chemistry and physics.
Also during 2018, I gave several interviews to electronic newspapers and radio and TV programs, about the role of Cx46 in diseases such as cancer.
https://m.elmostrador.cl/agenda-pais/vida-en-linea/vida-destacados/2019/01/10/estudio-podria-ayudar-adetener-metastasis-en-mujeres-con-cancer-de- mama / https://www.duna.cl/programa/aire-fresco/2019/01/10/programa-de-comunicacion-celular-en-cancer-udd-quebusca-mejorar-la-eficacia-de-los- current-treatments / http://biut.latercera.com/salud/2019/01/expertos-descubren-tratamiento-que-podria-disminuir-los-efectos-delcancer-de-mama/ https: //www.24horas. cl / videos / interviews24 / Chilean-study-could-help-stop-the-metastasis-of-breast-cancer-3058983 https://www.pauta.cl/ciencia-y-tecnologia/avanza-estudio-que -seeks-to-stop-metastasis-in-women-with-breast-cancer

- Also during 2018 and 2019 I participated in the Biology Study group 2 in ANID.

Finally, during the months of July and October 2019, with a group of 5 girls from Boston College La Farfana School in the Maipú commune, we did experiments in my laboratory on the effect of Chilote garlic and different types of paprika on the death of cancer cells in mom. They learned from cell culture to doing cell death experiments on a Nikon microscope. They found that a chilote garlic extract induces cell death even when the extract was highly diluted.


Activation of Intra-nodose Ganglion P2X7 Receptors Elicit Increases in Neuronal Activity Alcayaga, Julio; Vera, Jorge; Reyna-Jeldes, Mauricio; Covarrubias, Alejandra A. A.; Coddou, Claudio; Diaz-Jara, Esteban; Del Rio, Rodrigo; Retamal, Mauricio A. A. Article ISI CELLULAR AND MOLECULAR NEUROBIOLOGY (2023)
Assessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker Meza-Fuentes, Gabriela; Lopez, Rene; Vial, Cecilia; Cortes, Lina Jimena; Retamal, Mauricio A.; Delgado, Iris; Vial, Pablo Article ISI VIRUSES-BASEL (2023)
KI04 an Aminoglycosides-Derived Molecule Acts as an Inhibitor of Human Connexin46 Hemichannels Expressed in HeLa Cells Chang, Cheng-Wei T.; Poudyal, Naveena; Verdugo, Daniel A.; Pena, Francisca; Stehberg, Jimmy; Retamal, Mauricio A. Article ISI Biomolecules (2023)
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca<SUP>2+</SUP> dynamics Prieto-Villalobos, Juan; Lucero, Claudia M.; Rovegno, Maximiliano; Gomez, Gonzalo I.; Retamal, Mauricio A.; Orellana, Juan A. Article ISI BIOLOGICAL RESEARCH (2023)
Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR-dependent transmission and short-term fear memory in the basolateral amygdala Linsambarth, Sergio; Carvajal, Francisco J.; Moraga-Amaro, Rodrigo; Mendez, Luis; Tamburini, Giovanni; Jimenez, Ivanka; Antonio Verdugo, Daniel; Gomez, Gonzalo, I; Jury, Nur; Martinez, Pablo; van Zundert, Brigitte; Varela-Nallar, Lorena; Retamal, Mauricio A.; Martin, Claire; Altenberg, Guillermo A.; Fiori, Mariana C.; Cerpa, Waldo; Orellana, Juan A.; Stehberg, Jimmy Article ISI FASEB JOURNAL (2022)
Extracellular Cysteines Are Critical to Form Functional Cx46 Hemichannels Fernandez-Olivares, Ainoa; Duran-Jara, Eduardo; Verdugo, Daniel A.; Fiori, Mariana C.; Altenberg, Guillermo A.; Stehberg, Jimmy; Alfaro, Ivan; Francisco Calderon, Juan; Retamal, Mauricio A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
GABAergic Regulation of Astroglial Gliotransmission through Cx43 Hemichannels Jimenez-Dinamarca, Ivanka; Reyes-Lizana, Rachel; Lemunao-Inostroza, Yordan; Cardenas, Kevin; Castro-Lazo, Raimundo; Pena, Francisca; Lucero, Claudia M.; Prieto-Villalobos, Juan; Antonio Retamal, Mauricio; Andres Orellana, Juan; Stehberg, Jimmy Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Connexin Hemichannel Activation by S-Nitrosoglutathione Synergizes Strongly with Photodynamic Therapy Potentiating Anti-Tumor Bystander Killing Nardin, Chiara; Peres, Chiara; Putti, Sabrina; Orsini, Tiziana; Colussi, Claudia; Mazzarda, Flavia; Raspa, Marcello; Scavizzi, Ferdinando; Salvatore, Anna Maria; Chiani, Francesco; Tettey-Matey, Abraham; Kuang, Yuanyuan; Yang, Guang; Retamal, Mauricio A.; Mammano, Fabio Article ISI CANCERS (2021)
Connexin46 Expression Enhances Cancer Stem Cell and Epithelial-to-Mesenchymal Transition Characteristics of Human Breast Cancer MCF-7 Cells Acuna, Rodrigo A.; Varas-Godoy, Manuel; Herrera-Sepulveda, Diego; Retamal, Mauricio A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Over-activated hemichannels: A possible therapeutic target for human diseases Retamal, Mauricio A.; Fernandez-Olivares, Ainoa; Stehberg, Jimmy Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)
4-Hydroxynonenal induces Cx46 hemichannel inhibition through its carbonylation. Retamal, MA.; Fiori MC.; Fernandez-Olivares A.; Linsambarth, S.; Peña F.; Quintana D.; Stehberg J.; Altenberg, GA Article WOS/ISI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2020)
Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats. Lucero, CM.; Andrade, DC.; Toledo, C.; Díaz, HS.; Pereyra, KV.; Diaz-Jara, E.; Schwarz, KG.; Marcus, NJ.; Retamal, MA.; Quintanilla, RA.; Del Rio, R. Article WOS SCIENTIFIC REPORTS (2020)
Connexin-46 Contained in Extracellular Vesicles Enhance Malignancy Features in Breast Cancer Cells Acuña RA; Varas-Godoy, M.; Berthoud VM.; alfaro ie; Retamal, MA. Article WOS/ISI Biomolecules (2020)
Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3). Figueroa, VA; Jara O; Oliva, Carolina; Ezquer, M; Ezquer, F; Retamal, MA.; Martínez AD; Altenberg, GA; Vargas AA Article WOS FRONTIERS IN PHYSIOLOGY (2020)
Interferon-γ and High Glucose-Induced Opening of Cx43 Hemichannels Causes Endothelial Cell Dysfunction and Damage Sáez JC; Contreras-Duarte, S.; Labra, VC; Santibañez CA; Mellado LA; Inostroza CA; Alvear, TF; Retamal, MA.; Velarde V; Orellana, JA Article WOS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)
Role of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece? Rozas-Villanueva, María F.; Casanello, Paola; Retamal, Mauricio A Article WOS/ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease Vejar, Sebastián; Oyarzún, Juan E.; Retamal, Mauricio A; Ortiz, Fernando C.; Orellana, Juan A. Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2019)
Connexin and Pannexin-Based Channels in Oligodendrocytes=> Implications in Brain Health and Disease. Vejar S, Oyarzún JE; Retamal MA, Ortiz FC Article FRONTIERS IN CELLULAR NEUROSCIENCE (2019)
Cx46 hemichannel modulation by nitric oxide=> Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation. Retamal MA, Orellana VP; Arévalo NJ, Rojas CG; Arjona RJ, Alcaíno CA; González W, Canan JG; Moraga-Amaro R, Stehberg J; Reuss L, Altenberg GA. Article NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)
Are Polyunsaturated Fatty Acids Implicated in Histaminergic Dysregulation in Bipolar Disorder?=> AN HYPOTHESIS. Riveros, Maria Eugenia; Retamal, Mauricio Antonio. Article FRONTIERS IN PHYSIOLOGY (2018)
Redox-mediated regulation of connexin proteins; focus on nitric oxide. García, Isaac E; Sánchez, Helmut A; Martínez, Agustin D; Retamal, Mauricio A. Article BIOCHIMICA ET BIOPHYSICA ACTA (2018)
Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword Abudara, Verónica; Retamal, Mauricio A; del Rio, Rodrigo; Orellana, Juan A. Article ISI SCOPUS Frontiers in Molecular Neuroscience (2018)
Topical Application of Connexin43 Hemichannel Blocker Reduces Carotid Body-Mediated Chemoreflex Drive in Rats Andrade, David C.; Iturriaga, Rodrigo; Toledo, Camilo; Lucero, Claudia M.; Diaz, Hugo S.; Arce-Alvarez, Alexis; Retamal, Mauricio A; Marcus, Noah J.; Alcayaga, Julio; del Rio, Rodrigo; Gauda, EB; Prabhakar, N; Schultz, HD; Monteiro, ME; Wyatt, C Article ISI SCOPUS ADVANCES IN MATERNAL-FETAL BIOMEDICINE (2018)
Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity? Retamal, Mauricio A.; Riquelme. Manuel A., Stehberg; Jimmy, Alcayaga Article FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)
Contribution of peripheral and central chemoreceptors to sympatho-excitation in heart failure. Toledo, C; Andrade, DC; Lucero, C; Schultz, HD; Marcus, N; Retamal, M; Madrid, C Article JOURNAL OF PHYSIOLOGY-LONDON (2017)
Regulation of Connexin-Based Channels by Fatty Acids. Puebla, Carlos; Retamal, Mauricio Antonio; Acuña, Rodrigo; Sáez, Juan Carlos. Article Frontiers in Physiology (2017)
Carbon Monoxide Modulates Connexin Function through a Lipid Peroxidation-Dependent Process=> A Hypothesis. Retamal, MA. Article FRONTIERS IN PHYSIOLOGY (2016)
Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins. Pinto, Bernardo I; García, Isaac E; Pupo, Amaury; Retamal, Mauricio A; Martínez, Agustín D; Latorre, Ramón; González, Carlos Article The Journal of biological chemistry (2016)
Connexinopathies=> a structural and functional glimpse. García, IE; Prado, P; Pupo, A; Jara, O; Rojas-Gómez, D; Mujica, P; Flores-Muñoz, C; González-Casanova, J; Soto-Riveros, C; Pinto, BI; Retamal, MA; González, C; Martínez, AD. Article BMC CELL BIOLOGY (2016)
Extracellular Cysteine in Connexins: Role as Redox Sensors Retamal, MA.; Garcia, IE; Pinto, BI; Pupo, A; Baez, D; Stehberg, J; Del Rio R.; González C Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2016)
Extracellular Cysteine in Connexins=> Role as Redox Sensors. Retamal, MA; García, IE; Pinto, BI; Pupo, A; Báez, D; Stehberg, J; Del Rio, R; González, C. Article FRONTIERS IN PHYSIOLOGY (2016)
Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness Dalamon V.; Fiori M.C.; Figueroa V.A.; Oliva C.A.; Del Rio R.; Gonzalez, W; Canan J.; Elgoyhen A.B.; Altenberg G.A.; Retamal M.A. Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2016)
Regulation of Connexins Expression Levels by MicroRNAs, an Update. Calderón, Juan Francisco; Retamal, Mauricio Antonio. Article Frontiers in Physiology (2016)
Regulation of gap junction channels and hemichannels by phosphorylation and redox changes=> a revision. Pogoda, K; Kameritsch, P; Retamal, MA; Vega, JL. Article BMC CELL BIOLOGY (2016)
Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases Orellana, Juan A.; Retamal, Mauricio A; Moraga-Amaro, Rodrigo; Stehberg, Jimmy Article SCOPUS FRONTIERS IN INTEGRATIVE NEUROSCIENCE (2016)
Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases. Orellana, JA; Retamal, MA; Moraga-Amaro, R; Stehberg, J. Article FRONTIERS IN INTEGRATIVE NEUROSCIENCE (2016)
Carbon monoxide: A new player in the redox regulation of connexin hemichannels. Retamal MA, León-Paravic CG, Ezquer M, Ezquer F, Rio RD, Pupo A, Martínez AD, González C. Article IUBMB Life (2015)
Diseases associated with leaky hemichannels Retamal MA, Reyes EP, Garcia IE, Pinto B, Martinez AD, Gonzalez C. Article Front Cell Neurosci (2015)
Functional hemichannels formed by human connexin 26 expressed in bacteria Fiori MC.; Krishnan S.; Cortes, DM; Retamal, MA.; Reuss L.; Altenberg, GA; Cuello, LG Article ISI SCOPUS Bioscience Reports (2015)
Neuron-Glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis Rio R.D.; Quintanilla, R. A; Orellana J.A.; Retamal M.A. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2015)
Carbon Monoxide (CO) Is a Novel Inhibitor of Connexin Hemichannels Leon-Paravic C.G.; Figueroa V.A.; Guzman D.J.; Valderrama C.F.; Vallejos A.A.; Fiori M.C.; Altenberg G.A.; Reuss L.; Retamal M.A. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Connexin and Pannexin hemichannels are regulated by redox potential Retamal, Mauricio A Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2014)
Cxs and Panx- hemichannels in peripheral and central chemosensing in mammals. Reyes EP; Cerpa V; Corvalán L; Retamal MA Article Front Cell Neurosci (2014)
Extracellular gentamicin reduces the activity of con nexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells Figueroa V.A.; Retamal M.A.; Cea L.A.; Salas J.D.; Vargas A.A.; Verdugo C.A.; Jara O.; Martinez A.D.; Sáez, J.C. Article ISI SCOPUS FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Hemichannels; from the molecule to the function Retamal, MA.; Sáez JC Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2014)
Opening of pannexin- and con nexin-based channels increases the excitability of nodose ganglion sensory neurons Retamal, Mauricio A; Alcayaga, Julio; Verdugo, Christian A.; Bultynck, Geert; Leybaert, Luc; Sáez, Pablo J.; Fernández, Ricardo; León, Luis E.; Sáez, Juan C. Article ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Petrosal ganglion: a more complex role than originally imagined Retamal, Mauricio A; Reyes, Edison P.; Alcayaga, Julio Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2014)
ATP is required and advances cytokine-induced gap junction formation in microglia in vitro. Pablo J Sáez.; Kenji F. SHOJI.; Mauricio A Retamal.; Paloma A. HARCHA; Gigliola RAMÍREZ; Jean X. JIANG; R. Von Bernhardi; Juan C. Saez Article Mediators of Inflammation (2013)
Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules. Orellana JA,; Martinez AD,; Retamal MA. Article Neuropharmacology (2013)
Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation Giaume C.; Froger, N; Orellana, JA; Retamal, M.; Sáez JC Article ISI CONNEXIN CELL COMMUNICATION CHANNELS: ROLES IN THE IMMUNE SYSTEM AND IMMUNOPATHOLOGY (2013)
Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca2+-dependent pathway Figueroa, V.; Sáez PJ; Salas JD; Salas, D.; Jara O.; Martínez AD; Sáez JC; Retamal, MA. Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)
Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: Gap junctions versus hemichannels Iyyathurai J; D'hondt C; Wang N; De Bock M; Himpens B; Retamal MA; Stehberg J; Leybaert L; Bultynck G Article Neuropharmacology (2013)
Nitric oxide signaling in the retina: What have we learned in two decades? Vielma A.H.; Schmachtenberg O.; Retamal M.A. Article Brain Res (2012)
Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala Stehberg, J; Moraga-Amaro, R; Salazar C.; Becerra, A; Echeverria, C.; Orellana J.A.; Bultynck G.; Ponsaerts, R; Leybaert, L; Simon F.; Sáez, J.C.; Retamal M.A. Article ISI SCOPUS FASEB Journal (2012)
Biphasic effect of linoleic acid on connexin 46 hemichannels Retamal, MA.; Evangelista-Martinez F.; Leon-Paravic, CG; Altenberg, GA; Reuss L. Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2011)
Cell membrane permeabilization via connexin hemichannels in living and dying cells Saez J.C.; Schalper K.A.; Orellana J.A.; Shoji K.F.; Retamal M.A.; Bennett M.V.L. Article Exp Cell Res (2010)
FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels Garre, JM; Retamal, MA.; Cassina, P; Barbeito, L; Bukauskas, FF; Sáez JC; BENNETT, MVL; Abudara, V Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2010)
Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity Ponsaerts, R; De Vuyst, E; Retamal, M.; D'hondt, C; Vermeire, D; Wang N.; De Smedt H; Zimmermann P.; Himpens, B; Vereecke, J; Leybaert, L; Bultynck G. Article ISI SCOPUS FASEB Journal (2010)
Voltage-dependent facilitation of Cx46 hemichannels Retamal, MA.; Yin, SY; Altenberg, GA; Reuss L. Article ISI SCOPUS American Journal of Physiology - Cell Physiology (2010)
Modulation of Cx46 hemichannels by nitric oxide Retamal, MA.; Yin, SY; Altenberg, GA; Reuss L. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+](i) responses Schalper, KA; Palacios-Prado, N; Retamal, MA.; Shoji, KF; Martínez AD; Sáez JC Article ISI SCOPUS MOLECULAR BIOLOGY OF THE CELL (2008)
Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia Retamal, MA.; Froger, N; Palacios-Prado, N; Ezan P.; Sáez PJ; Sáez JC; Giaume C. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2007)
Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential Retamal, MA.; Schalper, KA; Shoji, KF; BENNETT, MVL; Sáez JC Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion MA Retamal; KA Schalper; KF Shojiz; JA Orellana; MVL Bennett; JC Sáez Article Journal of Membrane Biology (2007)
S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents Retamal, MA.; Cortes, CJ; Reuss L.; BENNETT, MVL; Sáez JC Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Connexin-based gap junction hemichannels: gating mechanisms Sáez JC; Retamal MA; Basilio D; Bukauskas FF; Bennett MV Article Biochimica et biophysica acta (2005)
Dopamine inhibits ATP-induced responses in the cat petrosal ganglion in vitro Alcayaga J.; Retamal, M.; Cerpa, V; Arroyo, J.; Zapata, P Article ISI SCOPUS BRAIN RESEARCH (2003)
Gap junction hemichannels in astrocytes of the CNS JC Saez; JE Contreras; FF Bukauskas; MA Retamal; MVL Bennett Article Acta physiologica scandinavica (2003)
Adenosine triphosphate-induced peripheral nerve discharges generated from the cat petrosal ganglion in vitro Alcayaga J.; Cerpa, V; Retamal, M.; Arroyo, J.; Iturriaga R.; Zapata, P Article ISI SCOPUS NEUROSCIENCE LETTERS (2000)


Linolenic and Linoleic Acid Induce the Opening of Connexin 43, 46 and 50 Hemichannel in Human Hela Cells Figueroa, VA; Retamal, MA. Abstract ISI BIOPHYSICAL JOURNAL (2014)
Purified Functional Human Connexin 26 Hemichannels Expressed in E. Coli Fiori M.; Cortes, MD; Retamal, MA.; Krishnan S.; Reuss L.; Altenberg, GA; Cuello, LG Abstract ISI BIOPHYSICAL JOURNAL (2014)
Is the Gain of Hemichannel Activity a Common Feature Shared by Cx26 Syndromic Deafness Mutants? Garcia, IE; Retamal, MA.; Jara O.; González C; Martínez AD Abstract ISI BIOPHYSICAL JOURNAL (2013)
Hemichannels formed by connexin43 are sensitive to changes in cellular redox potential Retamal, MA.; Cortes, CJ; BENNETT, MVL; Reuss L.; Sacz, JC Abstract ISI PLACENTA (2006)
Studies on putative gating mechanisms involved in opening Cx43 hemichannels in metabolically inhibited rat astrocytes Retamal, MA.; Cortes, CJ; Bukauskas, FF; Bennett, MV; Sáez JC Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2004)


Dopamine inhibits ATP-induced responses in the cat petrosal ganglion in vitro (vol 966, pg 283, 2003) Alcayaga J.; Retamal, M.; Cerpa, V; Arroyo, J.; Zapata, P Errata ISI BRAIN RESEARCH (2003)


CARBON MONOXIDE INHIBITS CX46 HCS THROUGH A LIPID PEROXIDATION-DEPENDENT PROCESS WHICH INCREASES CX46- CA2+ SENSITIVITY Retamal, Mauricio Antonio Proyecto (2016)
Carbon monoxide inhibits Cx46 HCs through a lipid peroxidation-dependent process, which increases Cx46- Ca2+ sensitivity FONDECYT (1160227) Proyecto 2016-2020 Inv. Principal
CARDIORESPIRATORY IMBALANCE IN HIGHT-OUTPUT HEART FAILURE: DISTINCT ROLES FOR THE CENTRAL PRE-SYMPATHETIC NEURONS AND THE PERIPHERAL CAROTID CHEMORECEPTORS IN THE PROGRESSION OF THE DISEASE Del Rio, Rodrigo; Retamal, Mauricio Antonio Proyecto (2014)
CARDIORESPIRATORY IMBALANCE IN HIGHT-OUTPUT HEART FAILURE=> DISTINCT ROLES FOR THE CENTRAL PRE-SYMPATHETIC NEURONS AND THE PERIPHERAL CAROTID CHEMORECEPTORS IN THE PROGRESSION OF THE DISEASE FONDECYT (1140275) Proyecto 2014-2018 Coinvestigador(a)
Estudio de vías de señalización intracelulares activadas por ácidos grasos omega-3 y sus efectos en el estado funcional de Hemicanales formados por Cxs del Cristalino PFCHA (3130577) Proyecto 2013-2015 Director(a)
UNSATURATED FATTY ACIDS CHANGE CX43, CX46 AND CX50 HEMICHANNELS PROPERTIES INDUCING LENS CELLS DAMAGE. Retamal, Mauricio Antonio Proyecto (2013)
Sensor de Voltaje de Canales de Iones=> Desde la Estructura a la Función PIA (ACT 1104) Proyecto 2012-2015 Coinvestigador(a)
Unsaturated fatty acids change Cx43, Cx46 and Cx50 hemichannels properties inducing lens cells damage FONDECYT (1120214) Proyecto 2012-2014 Inv. Principal
NITRIC OXIDE INDUCES FUNCTIONAL AND STRUCTURAL MODIFICATIONS IN CX46 GAP-JUNCTION HEMICHANNELS AND CHANNELS. FONDECYT (11080061) Proyecto 2008-2011 Inv. Principal
NITRIC OXIDE INDUCES FUNCTIONAL AND STRUCTURAL MODIFICATIONS IN CX46 GAP-JUNCTION HEMICHANNELS AND CHANNELS. Retamal, MA Proyecto (2008)
PROGRAMA BECAS DE APOYO PARA LA REALIZACION DE TESIS DOCTORAL PFCHA (403088) Proyecto 2003-2004 Inv. Principal
Beca Doctorado - Conicyt Retamal, Mauricio Antonio Proyecto (2001)
PROGRAMA NACIONAL DE BECAS DE POSTGRADO - DOCTORADO PFCHA (101134) Proyecto 2001-2004 Inv. Principal
Sensor de Voltage de Canales de Iones: Desde la Estructura a la Función González, Carlos; Retamal, Mauricio Antonio Proyecto (0)


Connexins in Cancer, the Possible Role of Connexin46 as a Cancer Stem Cell-Determining Protein Leon-Fuentes, Isidora M.; Salgado-Gil, Maria G.; Novoa, Maria S.; Retamal, Mauricio A. Review ISI Biomolecules (2023)
Hypertensive Nephropathy: Unveiling the Possible Involvement of Hemichannels and Pannexons Lucero, Claudia M.; Prieto-Villalobos, Juan; Marambio-Ruiz, Lucas; Balmazabal, Javiera; Alvear, Tanhia F.; Vega, Matias; Barra, Paola; Retamal, Mauricio A.; Orellana, Juan A.; Gomez, Gonzalo, I Review ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Role and Posttranslational Regulation of Cx46 Hemichannels and Gap Junction Channels in the Eye Lens Retamal, Mauricio A.; Altenberg, Guillermo A. Review ISI FRONTIERS IN PHYSIOLOGY (2022)
Connexins in melanoma: Potential role of Cx46 in its aggressiveness Orellana, Viviana P.; Tittarelli, Andres; Retamal, Mauricio A. Review ISI PIGMENT CELL & MELANOMA RESEARCH (2021)
Are Polyunsaturated Fatty Acids Implicated in Histaminergic Dysregulation in Bipolar Disorder?: AN HYPOTHESIS Riveros, ME; Retamal, MA. Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2018)
Carbon monoxide: A new player in the redox regulation of connexin hemichannels Retamal, MA.; Leon-Paravic, CG; Ezquer, M; Ezquer, F; Del Rio R.; Pupo, A; Martínez AD; González C Review ISI SCOPUS IUBMB Life (2015)
Diseases associated with leaky hemichannels Retamal, MA.; Reyes, EP; Garcia, IE; Pinto, B; Martínez AD; González C Review ISI SCOPUS Frontiers in Cellular Neuroscience (2015)
Nitric oxide signaling in the retina: What have we learned in two decades? Vielma, AH; Retamal, MA.; Schmachtenberg, O. Review Brain research (2012)
Cell membrane permeabilization via connexin hemichannels in living and dying cells Sáez JC; Schalper, KA; Retamal, MA.; Orellana, JA; Shoji, KF; BENNETT, MVL Review ISI SCOPUS Experimental Cell Research (2010)
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion Retamal, MA.; Schalper, KA; Shoji, KF; Orellana, JA; BENNETT, MVL; Sáez JC Review ISI JOURNAL OF MEMBRANE BIOLOGY (2007)
Connexin-based gap junction hemichannels: Gating mechanisms Sáez JC; Retamal, MA.; Basilio D.; Bukauskas, FF; BENNETT, MVL Review ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2005)
Gap junction hemichannels in astrocytes of the CNS Sáez JC; Contreras, JE; Bukauskas, FF; Retamal, MA.; BENNETT, MVL Review ISI ACTA PHYSIOLOGICA SCANDINAVICA (2003)

Mauricio Retamal

Associate Professor

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Julio Alcayaga

Profesor Titular

Biología

UNIVERSIDAD DE CHILE, FAC. CIENCIAS, DEPTO. BIOLOGÍA

Santiago, Chile

Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

Claudia Lucero

Asistente Investigación-Docente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Vania Figueroa

Directora InES Género y CTGénero, Coordinadora de Vinculación de Investigación Aplicada

Centro de Comunicación de las Ciencias

Universidad Autónoma de Chile

Santiago, Chile

Rodrigo Moraga

Postdoctoral researcher

Nuklear Medizin

Medizinische Hochschule Hannover

Hannover, Alemania

Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

Eduardo Ezquer

Director/Full Professor

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Carolina Oliva

Investigador Asociado

Facultad de Medicina

Universidad Andrés Bello

Santiago, Chile

Juan Oyarzún

Investigador postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

Carlos Manuel González

DIRECTOR ESCUELA

FACULTAD CIENCIAS DE LA VIDA

UNIVERSIDAD ANDRES BELLO

SANTIAGO, Chile

Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

Carolina Gonzalez

Luis Leon

Head of Bioinformatics and Computational Biology

Technology

PhageLab

Santiago, Chile

Daniela Salas

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Ricardo Fernández

Associate Professor

Salud

Universidad de Los Lagos

Osorno, Chile

Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

Hugo Diaz

PhD

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

Aníbal Vargas

Investigador postdoctoral

Universidad Mayor

Santiago, Chile

Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

Andrés Tittarelli

Profesor Asociado

Instituto Universitario de Investigación y Desarrollo Tecnológico (IDT)

Universidad Tecnológica Metropolitana

Santiago, Chile

Fernando Ortiz

profesor asistente

Departmento de Biología, Facultad de Quimica y Biología

Universidad de Santiago de Chile

Santiago, Chile

Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

Mauricio Antonio Retamal Lucero

Líneas de Investigación

Educación

Bachelor of Science / Biology, UNIVERSIDAD DE CHILE. Chile, 2000

PhD in Physiology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005

Experiencia Académica

Associate Professsor Full Time

Formación de Capital Humano

Difusión y Transferencia

Article (69)

Abstract (5)

Errata (1)

Proyecto (14)

Carbon monoxide inhibits Cx46 HCs through a lipid peroxidation-dependent process, which increases Cx46- Ca2+ sensitivity

CARDIORESPIRATORY IMBALANCE IN HIGHT-OUTPUT HEART FAILURE=> DISTINCT ROLES FOR THE CENTRAL PRE-SYMPATHETIC NEURONS AND THE PERIPHERAL CAROTID CHEMORECEPTORS IN THE PROGRESSION OF THE DISEASE

Estudio de vías de señalización intracelulares activadas por ácidos grasos omega-3 y sus efectos en el estado funcional de Hemicanales formados por Cxs del Cristalino

Sensor de Voltaje de Canales de Iones=> Desde la Estructura a la Función

Unsaturated fatty acids change Cx43, Cx46 and Cx50 hemichannels properties inducing lens cells damage

NITRIC OXIDE INDUCES FUNCTIONAL AND STRUCTURAL MODIFICATIONS IN CX46 GAP-JUNCTION HEMICHANNELS AND CHANNELS.

PROGRAMA BECAS DE APOYO PARA LA REALIZACION DE TESIS DOCTORAL

PROGRAMA NACIONAL DE BECAS DE POSTGRADO - DOCTORADO

Review (12)