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Diego E Varela Lekanda

Profesor Asociado

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Voltage dependent Calcium channel in hypertrophy; Chloride channels: structure, function and activation mechanisms

Ciencias Básicas con Mención en Física, Universidad de Chile. Chile, 2004
Doctor en Ciencias Biomédicas, Universidad de Chile. Chile, 2004

Profesor Asistente Full Time

Universidad de Chile

Santiago, Chile

2008 - 2019
Post-Doctorado Jornada Completa

Universidad de Chile

Santiago, Chile

2004 - 2004
Post-Doctorado Jornada Completa

University of Calgary

Calgary, Canada

2005 - 2008
Profesor Asociado Full Time

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago, Chile

2019 - A la fecha

Techician Full Time

CECS

Valdivia, Chile

2000 - 2002

Thesis Direction since 2008
Undergraduate Thesis
-Sergio Linsambarth (2014). Biotechnology. Faculty of Science, Universidad de Antofagasta, Antofagasta.
-Edgardo Salamanca (2013). Biotechnology, Faculty of Science, Universidad de la Frontera, Temuco.
-Tamara Veliz (Professional Practice, 2012). Biology, Faculty of Science, Universidad Católica de Chile.
-Edgardo Salamanca (Professional Practice, 2012). Biotechnology, Faculty of Science, Universidad de la Frontera, Temuco.

Graduate Thesis
-Cristian Moreno (2012), Master in Cell Biology. Facultad de Medicina, Universidad de Chile.

Undergraduate thesis in progress
-Hilda Alfaro. Biotechnology. Faculty of Science, Universidad Arturo Prat, Iquique. (Expected graduation date: August 2014).
- Nayareth Hidalgo. Biotechnology. Faculty of Science, Universidad de Antofagasta, Antofagasta. (Expected graduation date: August 2014).
Graduate thesis in progress.
-Cristian Moreno, PhD in Neuroscience. Facultad de Ciencias Biológicas, Universidad de Santiago de Chile.
-Matías Encina, Master in Biotechnology. Universidad Andrés Bello.
-Danna Morales, Master in Biotechnology. Universidad Andrés Bello.


KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis Rivas, Jose; Diaz, Nicolas; Silva, Ian; Morales, Danna; Lavanderos, Boris; Alvarez, Alhejandra; Paz Saldias, Maria; Pulgar, Eduardo; Cruz, Pablo; Maureira, Diego; Flores, Guillermo; Colombo, Alicia; Blanco, Constanza; Contreras, Hector R.; Jana, Fabian; Gallegos, Ivan; Concha, Miguel L.; Vergara-Jaque, Ariela; Poblete, Horacio; Gonzalez, Wendy; Varela, Diego; Trimmer, James S.; Caceres, Monica; Cerda, Oscar Article ISI FASEB JOURNAL (2020)
TRPM7 Mediates Kidney Injury, Endothelial Hyperpermeability and Mortality During Endotoxemia Gatica, Sebastian; Villegas, Vicente; Vallejos, Alejandro; Olivares, Pedro; Aballai, Victor; Lagos-Meza F.; Echeverria, Cesar; Cabello-Verrugio, C; Varela, Diego; Simon F. Article LABORATORY INVESTIGATION (2020)
Calcium-dependent inactivation controls cardiac L-type Ca2+ currents under beta-adrenergic stimulation Morales D.; Hermosilla T.; Varela D. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2019)
EB1-and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion Blanco, Constanza; Morales, Danna; Mogollones, Ignacio; Vergara-Jaque, Ariela; Vargas, Carla; Alvarez, Alhejandra; Riquelme, Denise; Leiva-Salcedo, Elias; Gonzalez, Wendy; Morales, Diego; Maureira, Diego; Aldunate, Ismael; Caceres, Monica; Varela, Diego; Cerda, Oscar Article ISI SCOPUS FASEB JOURNAL (2019)
Expression Suppression and Activity Inhibition of TRPM7 Regulate Cytokine Production and Multiple Organ Dysfunction Syndrome During Endotoxemia: A New Target for Sepsis Gatica S.; Eltit F.; Santibanez J.F.; Varela D.; Cabello-Verrugio C.; Simon F. Article ISI SCOPUS CURRENT MOLECULAR MEDICINE (2019)
OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-κB pathway on endothelial cells. Pérez L, Vallejos A; Echeverria C, Varela D; Cabello-Verrugio C, Simon F. Article LABORATORY INVESTIGATION (2019)
FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway Félix A. Urra, Felipe Muñoz; Miguel Córdova-Delgado, María Paz Ramírez; Bárbara Peña-Ahumada, Melany Rios; Pablo Cruz, Ulises Ahumada-Castro; Galdo Bustos, Eduardo Silva-Pavez; Rodrigo Pulgar, Danna Morales; Diego Varela, Juan Pablo Millas-Vargas; Evelyn Retamal, Oney Ramírez-Rodríguez; Hernán Pessoa-Mahana, Mario Pavani; Jorge Ferreira, César Cárdenas Article SCIENTIFIC REPORTS (2018)
Insights into the HyPer biosensor as molecular tool for monitoring cellular antioxidant capacity Hernandez, Helen; Parra, Alejandra;; Tobar. Nicolas; Molina, Jessica; Kallens, Violeta; Hidalgo, Miltha; Varela, Diego; Martinez, Jorge; Porras, Omar Article ISI SCOPUS REDOX BIOLOGY (2018)
Preventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survival Vallejos A.; Olivares, P; Varela, D; Echeverria, C; Cabello-Verrugio, C; Perez-Leighton, C; Simon, F Article ISI FRONTIERS IN PHYSIOLOGY (2018)
Preventive Leptin Administration Protects Against Sepsis Through Improving Hypotension, Tachycardia, Oxidative Stress Burst, Multiple Organ Dysfunction, and Increasing Survival. Vallejos A, Olivares P; Varela D, Echeverria C; Cabello-Verrugio C, Pérez-Leighton C Article FRONTIERS IN PHYSIOLOGY (2018)
Prolonged AT(1)R activation induces Ca(V)1.2 channel internalization in rat cardiomyocytes Hermosilla T.; Encina M.; Morales D.; Moreno C.; Conejeros C.; Alfaro-Valdés H.M.; Lagos-Meza F.; Simon F.; Altier C.; Varela D. Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
Ca-v beta(2) transcription start site variants modulate calcium handling in newborn rat cardiomyocytes Moreno C.; Hermosilla T.; Morales, D; Encina, M; Torres-Diaz, L; Díaz P; Sarmiento D.; Simon F.; Varela D. Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4 Cerda O.; Cáceres M.; Park, KS; Leiva-Salcedo, E; Romero A.; Varela D.; Trimmer, JS; Stutzin A. Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel Sarmiento D.; Montorfano I.; Cerda O.; Cáceres M.; Becerra, A; Cabello-Verrugio, C; Elorza, AA; Riedel C.; Tapia, P; Velasquez LA; Varela D.; Simon F. Article ISI SCOPUS Microvascular Research (2015)
Suppression of transient receptor potential melastatin 4 expression promotes conversion of endothelial cells into fibroblasts via transforming growth factor/activin receptor-like kinase 5 pathway Echeverria, C.; Montorfano I.; Cabello-Verrugio, C; Armisen, R; Varela D.; Simon F. Article ISI SCOPUS Journal of Hypertension (2015)
TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility Cáceres M.; Ortiz, L; Recabarren, T; Romero A.; Colombo, A; Leiva-Salcedo, E; Varela D.; Rivas J.; Silva I.; Morales, D; Campusano, C; Almarza O.; Simon F.; Toledo, H; Park, KS; Trimmer, JS; Cerda O. Article ISI SCOPUS PLOS ONE (2015)
Endotoxin Induces Fibrosis in Vascular Endothelial Cells through a Mechanism Dependent on Transient Receptor Protein Melastatin 7 Activity Echeverría, Cesar; Montorfano, Ignacio; Hermosilla, Tamara; Armisén, Ricardo; Velásquez, Luis A.; Cabello-Verrugio, Claudio; Varela, Diego; Simon, Felipe; Li, Liwu Article ISI SCOPUS PLOS ONE (2014)
Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel. Sarmiento D.; Montorfano I.; Cerda O.; Cáceres M.; Becerra, A; Cabello-Verrugio; Elorza, AA; Riedel C.; Tapia, P; Velasquez LA; Varela D.; Simon F. Article Microvasc. Res (2014)
Targeting the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Assembly Domain Attenuates Inflammation-induced Hypersensitivity Flynn R; Chapman K.; Iftinca M; Aboushousha R; Varela D.; Altier C. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Increased Expression of the Transient Receptor Potential Melastatin 7 Channel Is Critically Involved in Lipopolysaccharide-Induced Reactive Oxygen Species-Mediated Neuronal Death Nunez-Villena, F; Becerra, A; Echeverria, C.; Briceno, N; Porras O.; Armisen, R; Varela D.; Montorfano I.; Sarmiento D.; Simon F. Article ISI SCOPUS Antioxidants and Redox Signaling (2011)
L-type calcium channel beta subunit modulates angiotensin II responses in cardiomyocytes Hermosilla T.; Moreno C.; Itfinca M.; Altier C.; Armisen, R; Stutzin A.; Zamponi GW; Varela D. Article ISI CHANNELS (2011)
Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death Becerra, A; Echeverria, C.; Varela D.; Sarmiento D.; Armisen, R; Nunez-Villena, F; Montecinos, M; Simon F. Article ISI SCOPUS Cardiovascular Research (2011)
Hydrogen Peroxide Removes TRPM4 Current Desensitization Conferring Increased Vulnerability to Necrotic Cell Death Simon F.; Leiva-Salcedo, E; Armisen, R; Riveros A.; Cerda O.; Varela D.; Eguiguren, AL; Olivero P.; Stutzin A. Article ISI SCOPUS Journal of Biological Chemistry (2010)
P2X4 Activation Modulates Volume-sensitive Outwardly Rectifying Chloride Channels in Rat Hepatoma Cells Varela D.; Penna, A; Simon F.; Eguiguren, AL; Leiva-Salcedo, E; Cerda O.; Sala F.; Stutzin A. Article ISI SCOPUS Journal of Biological Chemistry (2010)
Scanning mutagenesis of the I-II loop of the Cav2.2 calcium channel identifies residues Arginine 376 and Valine 416 as molecular determinants of voltage dependent G protein inhibition. Tedford HW; Kisilevsky AE; Vieira LB; Varela D.; Chen L.; Zamponi GW Article Mol. Brain (2010)
D1 Receptors Physically Interact with N-Type Calcium Channels to Regulate Channel Distribution and Dendritic Calcium Entry Kisilevsky, Alexandra E.; Mulligan, Sean J.; Altier, Christophe; Iftinca, Mircea C.; Varela, Diego; Tai, Chao; Chen, Lina; Hameed, Shahid; Hamid, Jawed; MacVicar, Brian A.; Zamponi, Gerald W. Article NEURON (2008)
Differential interactions of Na+ channel toxins with T-type Ca2+ channels. Sun, H; Varela D.; Chartier D; Ruben PC; Nattel S; Zamponi GW; Leblanc N Article J. Gen. Physiol. (2008)
Making the T-type even tinier: corticotropin-releasing factor-mediated inhibition of low-voltage-activated calcium channel activity Varela DL; Hermosilla T.; Zamponi GW Article Mol Pharmacol. (2008)
Use 'em and lose 'em-activity-induced removal of calcium channels from the plasma membrane Varela D.; Zamponi GW Article NEURON (2008)
Activation of H2O2-induced VSOR CI(-)currents in HTC cells require phospholipase C gamma 1 phosphorylation and Ca2+ mobilisation Varela D.; Simon F.; Olivero P.; Armisen, R; Leiva-Salcedo, E; Jorgensen, F; Sala F.; Stutzin A. Article ISI SCOPUS CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2007)
Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants Heron, SE; Khosravani H; Varela D.; Bladen C; Williams TC; Newman MR; Scheffer, IE; Berkovic, SF; Mulley, JC; Zamponi GW Article Ann Neurol (2007)
Regulation of T-type calcium channels by Rho-associated kinase. Iftinca M; Hamid J; Chen L.; Varela D.; Tadayonnejad R; Altier C.; Turner RW; Zamponi GW Article Nat Neurosci. (2007)
Hydroxyl radical activation of a Ca2+-sensitive nonselective cation channel involved in epithelial cell necrosis Simon F.; Varela D.; Eguiguren, AL; Diaz, LF; Sala F.; Stutzin A. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)
NAD(P)H oxidase-derived H2O2 signals chloride channel activation in cell volume regulation and cell proliferation Varela D.; Simon F.; Riveros A.; Jorgensen, F; Stutzin A. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The voltage-dependent CIC-2 chloride channel has a dual gating mechanism Zuniga, L.; Niemeyer, MI; Varela D.; Catalán M.; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2004)
The voltage-dependent ClC-2 chloride channel has a dual gating mechanism Leandro Zuniga; Maria Isabel Niemeyer; Diego Varela; Marcelo Catalan; Luis Pablo Cid; Francisco Sepulveda Article ISI Journal of Physiology (2004)
The volume-activated chloride current depends on phospholipase c activation and intracellular calcium mobilization Varela D.; Simon F.; Riveros A.; Jorgensen, F; Stutzin A. Article ISI Advances in Experimental Medicine and Biology (2004)
Effect of an N-terminus deletion on voltage-dependent gating of the ClC-2 chloride channel Varela D.; Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2002)
Non-selective cation channels and oxidative stress- induced cell swelling Simon F.; Varela D.; Riveros A.; Eguiguren, AL; Stutzin A. Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2002)


Vascular endothelial fibrosis induced by endotoxin: characteristics, mechanism and therapeutic perspectives Simon F.; Echeverria, C.; Montorfano I.; Becerra, A; Varela D.; Hermosilla T.; Cabello-Verrugio, C; Armisen, R Abstract ISI CARDIOVASCULAR RESEARCH (2014)
SENSING FUNCTION OF CL- CHANNELS. DOES IT MAKE SENSE? Stutzin A.; Varela D. Abstract ISI JOURNAL OF PHYSIOLOGICAL SCIENCES (2009)
Protons and calcium modulate the open probability of a non selective cation channel in epithelial cells Leiva-Salcedo, E; Varela D.; Simon F.; Stutzin A. Abstract ISI PLACENTA (2006)
Effect of mutation C256A in rat ClC-2 on its gating behavior Zuniga, L.; Niemeyer, MI; Varela D.; Sepulveda, FV; Cid, LP Abstract ISI JOURNAL OF GENERAL PHYSIOLOGY (2003)


Millennium Nucleus of ion channels-associated diseases (MiNICAD) Oscar Cerda; Diego Varela; Sebastian Brauchi; Rodolfo Madrid; Wendy Gonzalez Proyecto (2017)
Millennium Nucleus of Ion Channels-Associated Diseases, Minicad Iniciativa Científica Milenio \| Subsecretaría de Economía y Empresas de Menor Tamaño \| Ministerio de Economía, Fomento y Turismo \| Gobierno de Chile (MiNICAD) Proyecto 2017-2020 Subdirector(a)
CAVBETA2 SUBUNITS AND BETA-ADRENERGIC STIMULATION MODULATES THE C-TERMINAL AUTOINHIBITORY COMPLEX OF CAV1.2 FONDECYT (1160900) Proyecto 2016-2019 Inv. Responsable
CaVβ2 subunits and β-adrenergic stimulation modulate the C-terminal autoinhibitory complex of CaV1.2 Diego Varela; Tamara Hermosilla; Felipe Simon Proyecto (2016)
Regulation of the trafficking and activity of TRPM4 by End Binding (EB) proteins and its role during cell migration Oscar Cerda; Diego Varela Proyecto (2016)
REGULATION OF THE TRAFFICKING AND ACTIVITY OF TRPM4 CHANNELS BY END BINDING (EB) PROTEINS AND ITS ROLE DURING CELL MIGRATION FONDECYT (1160518) Proyecto 2016-2020 Coinvestigador(a)
Role of Beta-arrestin and CaVb2 splice variants in the internalization of the macromolecular complex CaV1.2/AT1 FONDECYT (1120240) Proyecto 2012-2015 Inv. Principal
Role of β-arrestin and CaVβ2 splice variants in the internalization of the macromolecular complex CaV1.2 /AT1 Diego Varela; Felipe Simon; Tamara Hermosilla Proyecto (2012)
SEPSIS-INDUCED ENDOTHELIAL FIBROSIS=> ROLE OF TRPM4 AND TRPM7 ION CHANNELS AS NOVEL TARGETS FOR PREVENTION OF ENDOTHELIAL FIBROSIS DURING SEPSIS FONDECYT (1121078) Proyecto 2012-2015 Coinvestigador(a)
CEMC-FONDAP FONDAP (15010006) Proyecto 2009-2012 Coinvestigador(a)
The role of Calcium Channel Beta Subunits in the Modulation of L-type Calcium Currents by Angiotensin II in Cardiomyocytes FONDECYT (11080019) Proyecto 2008-2011 Inv. Principal
The Role of Calcium Channel Beta Subunits in the Modulation of L-type Calcium Currents by Angiotensin in Cardiomyocytes Diego Varela Proyecto (2008)
Molecular determinants of T-type calcium channel inactivation and its physiological significance Heart and Stroke Foundation Proyecto 2006-2009 Inv. Principal
Physiological effects of T-type calcium channel mutations linked to childhood absence epilepsy Alberta Heritage Foundation for Medical Research Proyecto 2005-2008 Inv. Principal
Sepsis-induced endothelial fibrosis: Role of TRPM4 and TRPM7 ion channels as novel targets for prevention of endothelial fibrosis during sepsis Felipe Simon; Diego Varela Proyecto (0)


Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans Simon F.; Varela D.; Cabello-Verrugio, C Review ISI SCOPUS Cellular Signalling (2013)

Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Darwin Leiva

Assistant professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

Monica Caceres

Profesor asociado

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

Ana Riveros

Profesor Asistente

Departamento de Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

Omar Porras

Assistant professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

Luis Cid

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

Cristian Moreno

Postod

The Solomon H. Snyder Department of Neuroscience

Johns Hopkins University

Maryland, Estados Unidos

Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

Luis Velasquez

Director and Full Professor

Medicine

Universidad SEK

Santiago, Chile

Pablo Olivero

Profesor Adjunto

Patologia y Fisiologia

Universidad de Valparaiso

Viña del Mar, Chile

Ariela Vergara

Assistant Professor

Bioinformatics

UNIVERSIDAD DE TALCA

Talca, Chile

Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Maria Niemeyer

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECS

Valdivia, Chile

Alvaro Becerra

Profesor Asociado

Ciencias Químico y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

Antonello Penna

Profesor Asociado

Anestesiología y Medicina Perioperatoria

Universidad de Chile

Santiago, Chile

Marcelo Catalan

Profesor Auxiliar

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

Pablo Tapia

Jefe Técnico Unidad de Paciente Crítico (UPC)

Unidad Paciente Critico (UPC)

Hospital Clinico Metropolitano La Florida

Santiago, Chile

Juan Santibáñez

Professor of Research

Molecular Oncology

Institute for Medical Research

Belgrade, Serbia

Alvaro Elorza

FULL PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Camilo Campusano

Doctorante

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Nicolas Tobar

Assistan Professor

Cellular and molecular Biology Laboratory

Institute of nutrition and food technology

Santiago, Chile

Pablo Díaz

Professional/Scientific advisor

Scientific Affairs

Instituto de Salud Públida de Chile

santiago, Chile

Fabián Jaña

Profesor Asistente

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

Miguel Concha

Full Professor

Anatomy and Developmental Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

IVAN GALLEGOS

PATHOLOGIST, LABORATORY DIRECTOR

PATHOLOGY

HOSPITAL CLINICO DE UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Carolina Conejeros

Enfermera

Nefrología

Hospital Clínico de la Universidad de Chile

Santiago, Chile

Claudio Perez

Profesor Asistente

Departamento de Ciencias Fisiológicas

Pontificia Universidad Catolica de Chile

Santiago, Chile

Antonello Penna

Profesor Asociado

UNIVERSIDAD DE CHILE

Santiago, Chile

Sebastián Gatica

Investigador Postdoctoral

Instituto Milenio de Inmunología e Inmunoterapia

Santiago, Chile

Tatiana Recabarren

Research assistant FONDECYT regular 1211931

Universidad San Sebastián

Concepción, Chile

Diego E Varela Lekanda

Líneas de Investigación

Educación

Ciencias Básicas con Mención en Física, Universidad de Chile. Chile, 2004

Doctor en Ciencias Biomédicas, Universidad de Chile. Chile, 2004

Experiencia Académica

Profesor Asistente Full Time

Post-Doctorado Jornada Completa

Post-Doctorado Jornada Completa

Profesor Asociado Full Time

Experiencia Profesional

Techician Full Time

Formación de Capital Humano

Article (39)

Abstract (4)

Proyecto (15)

Millennium Nucleus of Ion Channels-Associated Diseases, Minicad

CAVBETA2 SUBUNITS AND BETA-ADRENERGIC STIMULATION MODULATES THE C-TERMINAL AUTOINHIBITORY COMPLEX OF CAV1.2

REGULATION OF THE TRAFFICKING AND ACTIVITY OF TRPM4 CHANNELS BY END BINDING (EB) PROTEINS AND ITS ROLE DURING CELL MIGRATION

Role of Beta-arrestin and CaVb2 splice variants in the internalization of the macromolecular complex CaV1.2/AT1

SEPSIS-INDUCED ENDOTHELIAL FIBROSIS=> ROLE OF TRPM4 AND TRPM7 ION CHANNELS AS NOVEL TARGETS FOR PREVENTION OF ENDOTHELIAL FIBROSIS DURING SEPSIS

CEMC-FONDAP

The role of Calcium Channel Beta Subunits in the Modulation of L-type Calcium Currents by Angiotensin II in Cardiomyocytes

Molecular determinants of T-type calcium channel inactivation and its physiological significance

Physiological effects of T-type calcium channel mutations linked to childhood absence epilepsy

Review (1)