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Omar Hugo Porras Espinoza

Assistant professor

UNIVERSIDAD DE CHILE

Santiago, Chile

Our research area in focused on cellular physiology connecting redox and metabolic homeostasis in cellular models for intestinal epithelial barriers. Currently we are working with digested and fermented food as diet input to determine functionality

Doctor en Cs. Biomédicas, Universidad de Chile. Chile, 2006
Bioquímico, Universidad de Chile. Chile, 2000

Profesor Asistente Full Time

Universidad de Chile

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

2011 - A la fecha

Postdoc Other

Universidad de Chile

Chile

2008 - 2010
Postdoc Full Time

Karolinska Institutet

Estocolmo, Suecia

2006 - 2008

Juan Pablo Benitez: Master Student in medical and biological sciences. 2015.
Helen Hernandez: Engineer in Biotechnology. 2015
Camila Donoso: Master in Nutrition and Food minor in Human Nutrition. Ready to finish by 2017
Ailynne Sepúlveda, Miltha Hidalgo and Vania Rodríguez, two master students in Nutrition and Food minor in Human Nutrition are completing the graduation process ( first semester 2019)

Currently, we have one MsC Student(Yarella Pizarro) and Two PhD Students (Miltha Hidalgo and Christine Kriendl)

Christian Sagredo, Daniela Rivas, Kurt Pohlhammer, Jorge Meza, Benjamin Armijo, Francisca Chávez, Guillermo Lagos, Jaime Acevedo, José Coronado and Mará Paz Hernández have been trained at my lab in techniques such as cellular culture and imaging recording in living cells. This academic activity is a pre-requirement to obtain their final degree in Biotechnology Engineering

Since 2015, I have been in charge of outreach of the scientific meeting "ION IN THE VALLEY", which takes place in Paihuano, IV región, Chile. Our activivities have consisted in talks to students from local and public school from the zone. Currently, We are moving to integrate our initiatives with the comunity towards the creation of pedagogic enviroment designed to enrich the understanding of its local reality.

2018-2019 We have extended our collaborative connections with the Instituto Forestal located at Coyhaique, an extreme southern region of Chile and also with the Tarápaca University at the northern extrem of our country. We expect to shape a network for research the patrimonial/ancestral foods from patagonia to altiplanic environments and give scientific supported nutritional value to the communities that keep these living cultural items.

Beca Doctorado

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2004

I received the conicyt fellowship between 2004-2006.
Third place for best scientific poster

KAROLINSKA INSTITUTE

Chile, 2008

During my postdoc at KI, I was honored in a scientific meeting, in which a evaluating comitee decided that my poster was one of the best


Nocturnal Light Pollution Induces Weight Gain in Mice and Reshapes the Structure, Functions, and Interactions of Their Colonic Microbiota Sarmiento, Jose; Pulgar, Rodrigo.; Mandakovic, Dinka; Porras, Omar; Flores, Carlos A.; Luco, Diego; Trujillo, Carlos A.; Diaz-Esquivel, Briam; Alvarez, Cinthya; Acevedo, Alejandro; Catalan, Marcelo A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Epicatechin and quercetin exhibit in vitro antioxidant effect, improve biochemical parameters related to metabolic syndrome, and decrease cellular genotoxicity in humans Leyva-Soto, Aldo; Chavez-Santoscoy, Rocio Alejandra; Porras, Omar; Hidalgo-Ledesma, Miltha; Serrano-Medina, Aracely; Ramirez-Rodriguez, Ana Alejandra; Castillo-Martinez, Nydia Alejandra Article ISI FOOD RESEARCH INTERNATIONAL (2021)
Sucralose Stimulates Mitochondrial Bioenergetics in Caco-2 Cells Borquez, Juan Carlos; Hidalgo, Miltha; Rodriguez, Juan M.; Montana, Alejandra; Porras, Omar; Troncoso, Rodrigo; Bravo-Sagua, Roberto Article ISI Frontiers in Nutrition (2021)
Biological Redox Impact of Tocopherol Isomers Is Mediated by Fast Cytosolic Calcium Increases in Living Caco-2 Cells Hidalgo, Miltha; Rodríguez, Vania; Kreindl, Christine; Porras, Omar Article ISI SCOPUS ANTIOXIDANTS (2020)
Human umbilical artery endothelial cells from Large-for-Gestational-Age newborn have increased antioxidant efficiency and gene expression Carrasco-Wong, Ivo; Hernandez, Cherie; Jara-Gutierrez, Carlos; Porras, Omar; Casanello, Paola Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Insights into the HyPer biosensor as molecular tool for monitoring cellular antioxidant capacity Hernandez, Helen; Parra, Alejandra;; Tobar. Nicolas; Molina, Jessica; Kallens, Violeta; Hidalgo, Miltha; Varela, Diego; Martinez, Jorge; Porras, Omar Article ISI SCOPUS REDOX BIOLOGY (2018)
Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells Bernal-Sore, I; Navarro-Marquez, M; Osorio-Fuentealba, C; Diaz-Castro, F; del Campo, A; Donoso-Barraza, C; Porras O.; Lavandero, S; Troncoso, R Article ISI MOLECULAR AND CELLULAR ENDOCRINOLOGY (2018)
Glucose Promotes a Pro-Oxidant and Pro-Inflammatory Stromal Microenvironment Which Favors Motile Properties in Breast Tumor Cells Kallens V.; Tobar N.; Molina J.; Bidegain A.; Smith P.C.; Porras O.; Martínez J. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2017)
Modulation of Mammary Stromal Cell Lactate Dynamics by Ambient Glucose and Epithelial Factors Tobar N.; Porras O.; Smith P.C.; Barros L.F.; Martínez J. Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2017)
Real-Time H2O2 Measurements in Bone Marrow Mesenchymal Stem Cells (MSCs) Show Increased Antioxidant Capacity in Cells From Osteoporotic Women Román F.; Urra C.; Porras O.; Pino A.M.; Rosen C.J.; Rodríguez J.P. Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2017)
Functional interactions of fibrillar and oligomeric amyloid-β with alpha7 nicotinic receptors in Alzheimer's disease. Lilja A; Porras O; Storelli E.; Nordberg A; Marutle A Article Journal of Alzheimer Disease (2011)
Glutamate-induced metabolic changes influence the cytoplasmic redox state of hippocampal neurons Porras, OH; Stutzin A. Article ISI SCOPUS Biochemical and Biophysical Research Communications (2011)
Increased Expression of the Transient Receptor Potential Melastatin 7 Channel Is Critically Involved in Lipopolysaccharide-Induced Reactive Oxygen Species-Mediated Neuronal Death Nunez-Villena, F; Becerra, A; Echeverria, C.; Briceno, N; Porras O.; Armisen, R; Varela D.; Montorfano I.; Sarmiento D.; Simon F. Article ISI SCOPUS Antioxidants and Redox Signaling (2011)
Long-term effects of galantamine treatment on brain functional activities as measured by PET in Alzheimer's disease patients. Keller C, Kadir A, Forsberg A, Porras O, Nordberg A. Article ¿ (2011)
Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons. Nilbratt M, Porras O, Marutle A, Hovatta O, Nordberg A. Article JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)
Na+-Ca2+ cosignaling in the stimulation of the glucose transporter GLUT1 in cultured Astrocytes Porras, OH; Ruminot, I; Loaiza A.; Barros, LF Article ISI SCOPUS GLIA (2008)
Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis Matus, S; Burgos, PV; Bravo-Zehnder, M; Kraft R.; Porras, OH; Farías P.; Barros, LF; Torrealba, F.; Massardo, L; Jacobelli, S.; González A Article ISI SCOPUS JOURNAL OF EXPERIMENTAL MEDICINE (2007)
ATP steal between cation pumps: A mechanism linking Na + influx to the onset of necrotic Ca 2+ overload Castro J.; Ruminot, I; Porras O.H.; Flores, C. M.; Hermosilla T.; Verdugo E.; Hartel, S; Barros, L. F.; Venegas, F; Michea, L. Article CELL DEATH AND DIFFERENTIATION (2006)
Why glucose transport in the brain matters for PET Barros, LF; Porras, OH; Bittner CX Article ISI SCOPUS TRENDS IN NEUROSCIENCES (2005)
Glutamate mediates acute glucose transport inhibition in hippocampal neurons Porras, OH; Loaiza A.; Barros, LF Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2004)
Glutamate triggers rapid glucose transport stimulation in astrocytes as evidenced by real-time confocal microscopy Loaiza A.; Porras, OH; Barros, LF Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2003)
Hyperosmotic shock induces both activation and translocation of glucose transporters in mammalian cells Barros, LF; Barnes, K; Ingram, JC; Castro J.; Porras, OH; Baldwin, SA Article ISI SCOPUS PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2001)
Cytosolic [Ca2+] modulates basal GLUT1 activity and plays a permissive role in its activation by metabolic stress and insulin in rat epithelial cells Quintanilla, RA; Porras, OH; Castro J.; Barros, LF Article ISI SCOPUS CELL CALCIUM (2000)


Impact of Caffeic Acid and Quercetin on the Antioxidant Machinery Expression on Caco-2 Cells is Consistent with Changes in the Cytoplasmic Disulfide Transmission Capacity Hidalgo, M; Kallens, V; Tobar, N; Porras O. Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2019)
Antioxidant and Anti-Inflammatory Effects of Dietary Polyphenols on a Cellular Model for Intestinal Epithelia Porras O.; Hidalgo, M; Kallens, V; Tobar, N Abstract ISI ANNALS OF NUTRITION AND METABOLISM (2018)
Foxo1 subcellular dynamic and its impact on redox homeostasis in endothelial cells Porras O.; Benitez, JP Abstract ISI ACTA PHYSIOLOGICA (2014)
MATERNAL OBESITY IS ASSOCIATED WITH AN ALTERED ANTIOXIDANT SYSTEM IN THE UMBILICAL ARTERY ENDOTHELIUM: NEW INSIGHTS INTO VASCULAR FETAL PROGRAMMING BY MATERNAL OBESITY? Carrasco, I; Porras O.; Casanello, P Abstract ISI PLACENTA (2014)


IMPLEMENTACIÓN DE UN ARREGLO DE CÉLULAS CACO-2 PARA EVALUAR LAS PROPIEDADES INMUNOMODULADORAS DE COMPUESTOS NUTRICIONALES Porras, Omar ConferenceProceedingWhole This time I was invited to give a lecture about physiological aspects that must be incorporated in a modren approach to measure bioogical impact of nutrients and fitocompounds. (2018)
“¿Cuál es el impacto de la digestión sobre la bioactividad de los compuestos dietarios? Porras, Omar ConferenceProceedingWhole Invited to speak about modern technologies for a better understanding of biological impact of food and its components. (2018)


Transfering and starting of Redoxcell technology, a platform to evaluate the redox impact of food matrices Porras, Omar; Tobar. Nicolas; Pacheco, Igor Proyecto The aim of this project consist in the evaluation of redox impact of real food (fruits, oils, and others) in living intestinal cells by using an in vitro digestion protocol, known as infogest. (2019)
Development of a core facility for the analysis of foods by incorporating physiological phenomena, such as digestion and fermentation, with Twinshime technology Porras, Omar; Silva, Herman; Meisel, Lee; Reyes. Angélica Proyecto This project means the installation of a core facility for studying the interaction between diet-microbiota-host. The TWINSHIME allows the dynamic simulation of digestion and fermentative process that dietary compounds undergo. (2018)
Center for Advanced Research in Foods for Healthiness in life cycle (ABCVital) Troncoso, Rodrigo; Porras, Omar; Corvalan, Camila; Meisel, Lee; Pulgar, Rodrigo. Proyecto The main objective is to establish a platform for transdisciplinary research in nutrition and healthiness in the Universidad de Chile (2017)
Redoxcell: a platform for evaluating the antioxidant impact in living cells Porras, Omar; Martinez, Jorge Proyecto By measuring the signal of a fluorecent redox biosensor in living-cells, we develop a protocol to rank the antioxidant impact of phyto-compounds. (2016)
Redoxcell=> una plataforma para el registro del impacto antioxidante en células vivas Conicyt (IT15I10048) Proyecto 2016-2018 Director(a)
Use of cells expressing a redox biosensor for evaluating the antioxidant capacity of molecules of nutritional and therapeutic interest Porras, Omar; Martinez, Jorge Proyecto With this project we tested the proof of concept to use redox biosensor as reporter of antioxidant capacity in living mamalian cells exposed to dietary phenol compounds. (2014)
USO DE CÉLULAS QUE EXPRESAN UN BIOSENSOR REDOX PARA EVALUAR LA CAPACIDAD ANTIOXIDANTE DE MOLÉCULAS DE INTERÉS NUTRICIONAL Y TERAPÉUTICO FONDEF (ca13I10013) Proyecto 2014-2016 Director(a)
FUNCTIONAL ALTERATIONS IN IGF-1, BMP-2 AND WNT SIGNALING ARE DISTINCTIVE OF MESENCHYMAL STEM CELLS (MSCS) FROM THE BONE MARROW OF OSTEOPOROTIC WOMEN FONDECYT (1130045) Proyecto 2013-2016 Coinvestigador(a)
Functional alterations in IGF-1, BMP-2 and WNT signaling are distinctive of mesenchymal stem cells (MSCs) from the bone marrow of osteoporotic women Rodriguez, Juan Pablo.; Porras, Omar Proyecto Here, we use redox biosensors to characterize mesenchymal bone cells from healthy and osteoporotic women. This cellular feature was useful to identify some transcriptional factors that were mediating the differentiation into adipocytes (2013)
FUNCTIONAL ALTERATIONS IN IGF-1, BMP-2 AND WNT SIGNALING ARE DISTINCTIVE OF MESENCHYMAL STEM CELLS (MSCS) FROM THE BONE MARROW OF OSTEOPOROTIC WOMEN FONDECYT (1130045) Proyecto 2013-2017 Coinvestigador(a)
STUDY OF THE REGULATORY AXIS XBP-1/FOXO1 IN THE REDOX HOMEOSTASIS OF ENDOTHELIAL CELLS AND ITS REPERCUSSIONS ON THE NET BIOAVAILABILITY OF NITRIC OXIDE UNDER PHYSIOPATHOLOGICAL CONDITIONS FONDECYT (1120201) Proyecto 2012-2014 Inv. Responsable
STUDY OF THE REGULATORY AXIS XBP-1/FOXO1 IN THE REDOX HOMEOSTASIS OF ENDOTHELIAL CELLS AND ITS REPERCUSSIONS ON THE NET BIOAVAILABILITY OF NITRIC OXIDE UNDER PHYSIOPATHOLOGICAL CONDITIONS FONDECYT (1120201) Proyecto 2012-2015 Inv. Responsable
STUDY OF THE COUPLING MECHANISMS BETWEEN NEURONAL ACTIVITY AND CELLULAR METABOLISM IN NEURONS PERFORMING CODING UNDER PHYSIOLOGICAL AND ALZHEIMER"S CONDITIONS. FONDECYT (3090030) Proyecto 2008-2010 Inv. Responsable
STUDY OF THE COUPLING MECHANISMS BETWEEN NEURONAL ACTIVITY AND CELLULAR METABOLISM IN NEURONS PERFORMING CODING UNDER PHYSIOLOGICAL AND ALZHEIMER"S CONDITIONS. FONDECYT (3090030) Proyecto 2008-2010 Inv. Responsable
Study of the coupling mechanisms between neuronal activity and cellular metabolism in neurons performing coding under physiological and Alzheimer´s conditions Porras, Omar Proyecto The tight relationship between redox and metabolic homeostasis was studied in primary neurons and astrocytes form neonatal rats. Intercellular metabolic communication was demonstrated. (2008)
Patogenia de la muerte necrótica en células hepáticas=> disección de mecanismos moleculares FONDEF (1020648) Proyecto 2002-2004 Personal técnico y/o de apoyo
Mecanismos moleculares de la activación de GLUT1 por hipoxia. FONDECYT (1990782) Proyecto 1999-2002 Personal técnico y/o de apoyo
Study of the regulatory axis XBP-1/FoXO1 in the redox homeostasis of endothelial cells and its repercussions on the net bioavailability of nitric oxide under physiopathological conditions Porras, Omar Proyecto By monitoring the redox homeostasis in human endothelial cells we study the connection between transcriptional factors and external metabolic inputs (0)


Revisiting the physiological benefits of legume consumption Miltha Hidalgo; Vania Rodríguez; Omar Porras Review WOS-ESCI SCIELO SCOPUS REVISTA CHILENA DE NUTRICION (2018)
A quantitative overview of glucose dynamics in the gliovascular unit Barros, LF; Bittner CX; Loaiza A.; Porras, OH Review ISI GLIA (2007)

Omar Porras

Assistant professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Nicolas Tobar

Assistan Professor

Cellular and molecular Biology Laboratory

Institute of nutrition and food technology

Santiago, Chile

Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

Patricio Smith

Associate Professor

Medicine / Dentistry

Pontificia Universidad Católica de Chile

Santiago, Chile

ivo carrasco

Investigador

Universidad San Sebastián

Santiago, Chile

Miltha Hidalgo

LAB MANAGER

Universidad de Chile

SANTIAGO, Chile

Patricio Smith

Profesor Asociado

Odontología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Christine Kreindl

Instructor

Ciencias de salud

Universidad Autónoma de Chile

Santiago, Chile

PATRICIA BURGOS

Associate Professor Programa de Doctorado en Biología Celular y Biomedicina CEBICEM

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Carlos Jara

Profesor adjunto

Universidad de Valparaíso

Reñaca, Chile

Alvaro Becerra

Profesor Asociado

Ciencias Químico y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

Camila Donoso

Tesista Doctorado Nutrición y Alimentos

Laboratorio de Investigación en Nutrición y Actividad Física

Instituto de Nutrición y Tecnología de Alimentos

Santiago, Chile

Maria Massardo

Docente Investigador

Medicina

Universidad San Sebastián

Santiago, Chile

Andrea del Campo

Profesor Asistente, Investigador Principal

Departamento de Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

Maria Matus

Principal Investigator

Fundacion Ciencia & Vida

Santiago, Chile

Rodrigo Pulgar

Profesor/Investigador asistente

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

JUAN RODRIGUEZ

FULL PROFESSOR

LABORATORY OF CELL BIOLOGY

INTA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

DINKA MANDAKOVIC

Assistant Professor

GEMA Center

Universidad Mayor

Santiago, Chile

Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

Alejandro Acevedo

César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Marcelo Catalan

Profesor Auxiliar

Facultad de Medicina

Universidad Austral de Chile

Valdivia, Chile

Juan Bórquez

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

Omar Hugo Porras Espinoza

Líneas de Investigación

Educación

Doctor en Cs. Biomédicas, Universidad de Chile. Chile, 2006

Bioquímico, Universidad de Chile. Chile, 2000

Experiencia Académica

Profesor Asistente Full Time

Experiencia Profesional

Postdoc Other

Postdoc Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Beca Doctorado

Third place for best scientific poster

Article (23)

Abstract (4)

ConferenceProceedingWhole (2)

Proyecto (18)

Redoxcell=> una plataforma para el registro del impacto antioxidante en células vivas

USO DE CÉLULAS QUE EXPRESAN UN BIOSENSOR REDOX PARA EVALUAR LA CAPACIDAD ANTIOXIDANTE DE MOLÉCULAS DE INTERÉS NUTRICIONAL Y TERAPÉUTICO

FUNCTIONAL ALTERATIONS IN IGF-1, BMP-2 AND WNT SIGNALING ARE DISTINCTIVE OF MESENCHYMAL STEM CELLS (MSCS) FROM THE BONE MARROW OF OSTEOPOROTIC WOMEN

FUNCTIONAL ALTERATIONS IN IGF-1, BMP-2 AND WNT SIGNALING ARE DISTINCTIVE OF MESENCHYMAL STEM CELLS (MSCS) FROM THE BONE MARROW OF OSTEOPOROTIC WOMEN

STUDY OF THE REGULATORY AXIS XBP-1/FOXO1 IN THE REDOX HOMEOSTASIS OF ENDOTHELIAL CELLS AND ITS REPERCUSSIONS ON THE NET BIOAVAILABILITY OF NITRIC OXIDE UNDER PHYSIOPATHOLOGICAL CONDITIONS

STUDY OF THE REGULATORY AXIS XBP-1/FOXO1 IN THE REDOX HOMEOSTASIS OF ENDOTHELIAL CELLS AND ITS REPERCUSSIONS ON THE NET BIOAVAILABILITY OF NITRIC OXIDE UNDER PHYSIOPATHOLOGICAL CONDITIONS

STUDY OF THE COUPLING MECHANISMS BETWEEN NEURONAL ACTIVITY AND CELLULAR METABOLISM IN NEURONS PERFORMING CODING UNDER PHYSIOLOGICAL AND ALZHEIMER"S CONDITIONS.

STUDY OF THE COUPLING MECHANISMS BETWEEN NEURONAL ACTIVITY AND CELLULAR METABOLISM IN NEURONS PERFORMING CODING UNDER PHYSIOLOGICAL AND ALZHEIMER"S CONDITIONS.

Patogenia de la muerte necrótica en células hepáticas=> disección de mecanismos moleculares

Mecanismos moleculares de la activación de GLUT1 por hipoxia.

Review (2)