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JUAN CARLOS AGUILLON GUTIERREZ

PROFESSOR

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Immunology of rheumatoid arthritis (RA) / Biology of tolerogenic dendritic cells / New T-cell autoantigen epitopes with potential to design a tolerogenic DC-based treatment for RA / Mechanisms of immunological tolerance / Recombinant antibodies

Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1986
Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2006
Biochemistry, UNIVERSIDAD DE CONCEPCION. Chile, 1986

ASSISTANT PROFESSOR Full Time

UNIVERSIDAD DE CHILE

FACULTY OF VETERINARY AND LIVESTOCK SCIENCES

SANTIAGO, Chile

1992 - 1997
ASSOCIATE PROFESSOR Full Time

UNIVERSIDAD DE CHILE

FACULTY OF MEDICINE

SANTIAGO, Chile

1997 - 2006
PROFESSOR Full Time

UNIVERSIDAD DE CHILE

FACULTY OF MEDICINE

SANTIAGO, Chile

2006 - A la fecha
CHAIRMAN Full Time

UNIVERSIDAD DE CHILE

FACULTY OF MEDICINE

SANTIAGO, Chile

2004 - 2017

Full Professor Full Time

UNIVERSIDAD DE CHILE

Santiago, Chile

2006 - A la fecha
Chairman of Immunology Program Full Time

UNIVERSIDAD DE CHILE

Santiago, Chile

2004 - 2017
Associate Professor Full Time

UNIVERSIDAD DE CHILE

Santiago, Chile

1997 - 2005
Assistant Professor Full Time

UNIVERSIDAD DE CHILE

Santiago, Chile

1993 - 1996
Instructor Full Time

UNIVERSIDAD DE CHILE

Santiago, Chile

1992 - 1993

POSTDOCTORAL RESEARCHERS

Postdoctoral Trainee: Evelyn Menares associated to the grant ¨Preclinical evaluation and registration of tolerogenic dendritic cells pulsed with autoantigenic peptides (TOLDeC-AP) for an antigen-specific immunotherapy for rheumatoid arthritis¨ from the Fund for the Promotion of Scientific and Technological Development (FONDEF-IDeA-Chile ID18I10243). 2016 - 2018.

Postdoctoral Trainee: Octavio Aravena associated to the grant ¨Auto-antigen peptides presented by tolerogenic dendritic cells: A personalized therapy to re-instruct the immune system of patients with rheumatoid arthritis¨ from the Fund for the Promotion of Scientific and Technological Development (FONDEF-IDeA-Chile ID15I10080). 2016 - 2018.

Fondecyt Post-Doctoral Grant 3150453. Principal Investigator: Katina Schinnerling. Sponsor Investigator: JC Aguillón. Establishment of a humanized mouse model of arthritis: An approach for studying autoimmune processes in vivo and testing novel therapeutic intervention strategies. November, 2014 – November, 2017.

Conicyt National Competition of Insertion of Advanced Human Capital in the Academy 2011, Grant 791100001. Principal Investigator: Karina Pino. Sponsor Investigator: JC Aguillón. “Strengthening research lines in cellular therapies in autoimmunity and transplantation ". October, 2011 – October, 2014.

Postdoctoral Trainee: Pablo Sotelo associated to grant "Development of an optimized expression system for the production of therapeutic antibodies" from the Fund for the Promotion of Scientific and Technological Development (FONDEF-Chile D09I1190). 2010 - 2014.

SUPERVISION OF Ph.D. M.Sc. THESIS:

17. ASHLEY ANDRÉS FERRIER ESPÓSITO. Biomedical Sciences Doctoral Program, Facultad de Medicina, Universidad de Chile. “Study of the interaction between regulatory B lymphocytes and monocytes by the TIM-1/TIM-1L axis as mechanism of immune regulation: implications in rheumatoid arthritis”. 2019 – In progress.

16. JAXAIRA AMILENE MAGGI ORELLANA. Biomedical Sciences Doctoral Program, Facultad de Medicina, Universidad de Chile. “Identification and characterization of immunodominants T cell epitopes in patients with rheumatoid arthritis”. 2018 – In progress.

15. JORGE ALEJANDRO BERENDSEN MELLA. Biological Sciences Master Program, Facultad de Medicina, Universidad de Chile. “Role of Siglec 2 and Siglec 10 in the atenuation of signals invloved in the IL-10 secretion by human B lymphocytes”. 2013 – 2016.

14. OCTAVIO ALEXIS ARAVENA MADARIAGA. Biotechnology Doctoral Program, Universidad Andrés Bello. “Study on the function of TIM-1 in the tolerance induction by human regulatory B cells in health and autoimmunity”. 2013 – 2016.

13. PAULINA ANDREA GARCÍA GONZÁLEZ. Biomedical Sciences Doctoral Program, Facultad de Medicina, Universidad de Chile. “Study of molecular networks associated to tolerance in dendritic cells of patients with rheumatoid arthritis and its expression in response inflammatory modulators”. 2015 – 2018.

12. MATÍAS GUTIÉRREZ GONZÁLEZ. Pharmacology Doctoral Program, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. “Effects of pharmacology induction of UPR and mTOR on the production of recombinant antibodies in CHO cells”. 2013 –2017.

11. BÁRBARA PAZ PESCE REYES. Biomedical Sciences Doctoral Program, Facultad de Medicina, Universidad de Chile. “Effects of tumor necrosis factor and interleukin-6 on the Th1 and Th17 axes in the context of rheumatoid arthritis”. 2010 – 2014.

10. MARÍA CORINA PEÑA JIMÉNEZ. Biological Sciences Master Program, Facultad de Medicina, Universidad de Chile. “Determination of the therapeutical value of de la administración de regulatory dendritic cells administration in the murine model of arthritis by histopathological evaluation of proinflammatory cytokines in articulations samples”. 2008 – 2013.

9. PILAR FRANCISCA GAJARDO ORELLANA. Medical Sciences Master Program, Facultad de Medicina, Universidad de Chile. “Caracterization of Foxp3+ regulatory T lymphocite subset in peripheral blood of patients with nasal polyposis”. 2008 – 2013.

8. JAIME PEÑA ALVAREZ. Engineering Sciences Master Program, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile. “CHO cells suspension culture for the production of a chimeric antibody against human tumor necrosis factor”. 2007 – 2011.

7. ALEJANDRO ESCOBAR ÁLVAREZ. Biomedical Sciences Doctoral Program. Facultad de Medicina, Universidad de Chile. “Regulatory dendritic cells modulating the immune response in latex allergy”. 2006 – 2010.

6. DIEGO CATALÁN MARTINA. Biomedical Sciences Doctoral Program. Facultad de Medicina, Universidad de Chile. “Mechanisms involved in the response against citrulinated proteins in rheumatoid arthritis”. 2006 – 2010.

5. ANTONIO SERRANO GÓMEZ. Biochemistry Doctoral Program, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. “Study of chaperone proteins associated to the MIC molecule in human placent”. 2006 – 2009.

4. ADAM AGUIRRE DUCLER. Biochemistry Master of Science Program. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. “Modulation of the cellular immune response with tolerogenic dendritic cells in rheumatoid arthritis”. 2004 – 2008.

3. LORENA SALAZAR ARAVENA. Biomedical Sciences Doctoral Program. Facultad de Medicina, Universidad de Chile. “Modulation of the T helper response by immunization with tolerogenic dendritic cells in collagen induced murine arthritis”. 2003 – 2007.

2. FERMÍN GONZÁLEZ BERGAS. Master of Science Program. Facultad de Odontología, Universidad de Chile. “Association of IL-1 y TNF? polymorphisms with aggressive periodontitis”. 2004 – 2007.

1. LORENA FERREIRA ARANGUREN. Clinical Immunology Specialist Program. Facultad de Medicina, Universidad de Chile. “Cloning and preliminary evaluation of the diagnostic potential of recombinant Tc45, a Trypanosoma cruzi antigen”. 1997 – 1999.

SUPERVISION OF GRADUATE STUDENTS:

29. NICOLÁS RODRIGO ASTUDILLO TORO. Facultad de Químicas y Biología, Universidad de Santiago de Chile. 2020 - 2021.

28. BYRON MORENO VICTORIANO. Facultad de Medicina, Universidad de Chile. 2020 - 2021.

27. CAMILA TAMARA ORTIZ SALAZAR. Facultad de Medicina, Universidad de Chile. 2019 - 2020.

26. IGNACIO ANDRÉS OSORIO CARO. Facultad de Medicina, Universidad de Chile. 2016.

25. GABRIELA TAMARA UBILLA OLGUÍN. Instituto de Química, Pontificia Universidad Católica de Valparaiso de Chile. 2014 – 2018.

24. ASHLEY ANDRÉS FERRIER ESPÓSITO. Facultad de CIencias, Universidad de Chile. 2013 –2016.

23. LUIS ALFONSO VALENZUELA VILLA. Facultad de Ciencias, Universidad de Chile. 2013 –2016.

22. CAROLINA ELISA SCHÄFER ADRIAZOLA. Instituto de Química, Pontificia Universidad Católica de Valparaiso de Chile. 2012 – 2015.

21. JAVIER IGNACIO CAMPOS ACUÑA. Facultad de Ciencias, Universidad de Chile. 2013 –2015.

20. JAXAIRA AMILENE MAGGI ORELLANA. Facultad de Ciencias, Universidad de Chile. 2013 –2014.

19. LORENA DEL PILAR HOYOS PARRA. Facultad de Farmacia, Universidad de Concepción. 2010 – 2013.

18. DARÍO DE JESUS VERGARA SALAZAR. Facultad de Medicina, Universidad de Chile. March, 2013 – August , 2013.

17. RODRIGO ALONSO MORALES CASTRO. Facultad de CIencias, Universidad de Chile. 2011 – 2013.

16. PAULINA ANDREA GARCÍA GONZÁLEZ. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. 2010 – 2013.

15. NORBERTO ANDRÉS COLLAZO MUÑOZ. Facultad de CIencias, Universidad de Chile. 2008 – 2011.

14. NICOLÁS RUIZ-TAGLE PHILLIPS. Facultad de CIencias, Universidad de Chile. 2008 – 2010.

13. DAVID GARATE OYARCE. Instituto de Química, Pontificia Universidad Católica de Valparaiso de Chile. 2008 – 2010.

12. SERGIO MERCADO ARGANDOÑA. Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile. 2008 – 2009.

11. JUAN PABLO MALDONADO ZAVALA. Facultad de Químicas y Biología, Universidad de Santiago de Chile. 2008 – 2009.

10. NICOLE MACARENA ROJAS COLONELLI. Facultad de Químicas y Biología, Universidad de Santiago de Chile. 2007 – 2008.

9. CARLOS CUEVAS LIZANA. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. 2005 – 2008.

8. PAULA ABELLO CÁCERES. Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile. 2004 – 2007.

7. OCTAVIO ARAVENA MADARIAGA. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. 2004 – 2006.
6. JIMENA CUENCA MORENO.. Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. 1999 – 2002.

5. ANA MARÍA GAETE DOÑA. Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile. 1998 – 2001.

4. PILAR CAMPOS ORTIZ. Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile. 1998 – 2000.

3. CLAUDIO PÉREZ NÚÑEZ. Facultad de Ciencias, Universidad Austral de Chile. 1997 – 2000.

2. ADAM AGUIRRE DUCLER. Facultad de Medicina Veterinaria, Universidad de Concepción. 1995 – 1996.

1. VIVIANA FERREIRA ARANGUREN. Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile. 1994 – 1995.


Immunosuppressive Mechanisms of Regulatory B Cells Catalán, Diego; Mansilla, Andres; Ferrier, Ashley; Soto, Lilian; Oleinika, Kristine; Aguillón, Juan Carlos; Aravena, Octavio Article FRONTIERS IN IMMUNOLOGY (2021)
Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated SNPs in Caucasian and Asian populations Castro-Santos, P.; Verdugo, R. A.; Alonso-Arias, R.; Gutierrez, M. A.; Suazo, J.; Aguillon, J. C.; Olloquequi, J.; Pinochet, C.; Lucia, A.; Quinones, L. A.; Diaz-Pena, R. Article ISI SCIENTIFIC REPORTS (2020)
Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies. Schinnerling, K; Rosas, C; Soto, L; Thomas, R; Aguillón, JC. Article ISI FRONTIERS IN IMMUNOLOGY (2019)
Regulation of Tolerogenic Features on Dexamethasone-Modulated MPLA-Activated Dendritic Cells by MYC Garcia-Gonzalez, Paulina A.; Maggi, Jaxaira; Schinnerling, Katina; Sepulveda-Gutierrez, Alejandro; Soto, Lilian; Neire, Oscar; Mehdi, Ahmed M.; Nel, Hendrik J.; Pesce, Barbara; Aravena, Octavio; Carmen Molina, Maria; Catalan, Diego; Thomas, Ranjeny; Verdugo, Ricardo A.; Carlos Aguillon, Juan Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
Transcription factor engineering in CHO cells for recombinant protein production. Gutierrez-Gonzalez, M; Latorre, Y; Zuñiga, R; Aguillon, JC; Molina, MC; Altamirano, C Article ISI CRITICAL REVIEWS IN BIOTECHNOLOGY (2019)
Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNF alpha production in CHO cells Torres, Mauro; Zúñiga, Roberto; Gutierrez, Matias; Vergara, Mauricio; Collazo, Norberto; Reyes, Juan; Berrios, Julio; Aguillón, Juan Carlos; Molina, María Carmen; Altamirano, Claudia Article ISI SCOPUS PLOS ONE (2018)
Dexamethasone and Monophosphoryl lipid a induce a Distinctive Profile on Monocyte-Derived Dendritic cells through Transcriptional Modulation of genes associated With essential Processes of the immune response Garcia-Gonzalez, PA; Schinnerling, K; Sepulveda-Gutierrez, A; Maggi, J; Mehdi, AM; Nel, HJ; Pesce, B; Larrondo, ML; Aravena, O; Molina, MC; Catalán, D; Thomas, R; Verdugo, RA; Aguillón, JC Article ISI SCOPUS Frontiers in immunology (2017)
STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells Garrido-Tapia, Macarena; Hernández, Carolina J.; Ascui, Gabriel; Kramm, Karina; Morales, Marcela; Gárate, Valentina; Zúñiga, Roberto; Bustamante, Marco; Aguillón, Juan Carlos; Catalán, Diego; Ribeiro, Carolina H.; Molina, María Carmen Article ISI SCOPUS IMMUNOBIOLOGY (2017)
The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis. Schinnerling, K; Aguillón, JC; Catalán, D; Soto, L. Article CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2017)
TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients. Aravena, O; Ferrier, A; Menon, M; Mauri, C; Aguillón, JC; Soto, L; Catalán, D. Article ARTHRITIS RESEARCH THERAPY (2017)
Triatoma infestans Calreticulin: Gene Cloning and Expression of a Main Domain That Interacts with the Host Complement System. Weinberger, K; Collazo, N; Aguillón, JC; Molina, MC; Rosas, C; Peña, J; Pizarro, J; Maldonado, I; Cattan, PE; Apt, W; Ferreira, A. Article ISI AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2017)
Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients Ribeiro, CH; Kramm, K.; Galvez-Jiron, F; Pola, V.; Bustamante, M; Contreras, HR; Sabag A.; Garrido-Tapia, M; Hernandez, CJ; Zúñiga R.; Collazo, N.; Sotelo, PH; Morales C. ; Mercado L.; Catalan, D; Aguillón JC; Molina, MC Article ISI SCOPUS ONCOLOGY REPORTS (2016)
Dexamethasone and Monophosphoryl Lipid A-Modulated Dendritic Cells Promote Antigen-Specific Tolerogenic Properties on Naive and Memory CD4+ T Cells. Maggi, J; Schinnerling, K; Pesce, B; Hilkens, CM; Catalán, D; Aguillón, JC. Article ISI FRONTIERS IN IMMUNOLOGY (2016)
Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies. Lord, P; Spiering, R; Aguillon, JC; Anderson, AE; Appel, S; Benitez-Ribas, D; Ten Brinke, A; Broere, F; Cools, N; Cuturi, MC; Diboll, J; Geissler, EK; Giannoukakis, N; Gregori, S; van Ham, SM; Lattimer, S; Marshall, L; Harry, RA; Hutchinson, J; Isaacs, JD Article ISI PEERJ (2016)
Tolerogenic dendritic cells for reprogramming of lymphocyte responses in autoimmune diseases. García-González, P; Ubilla-Olguín, G; Catalán, D; Schinnerling, K; Aguillón, JC. Article ISI AUTOIMMUNITY REVIEWS (2016)
Treatment with Dexamethasone and Monophosphoryl Lipid A Removes Disease-Associated Transcriptional Signatures in Monocyte-Derived Dendritic Cells from Rheumatoid Arthritis Patients and Confers Tolerogenic Features. García-González, PA; Schinnerling, K; Sepúlveda-Gutiérrez, A; Maggi, J; Hoyos, L; Morales, RA; Mehdi, AM; Nel, HJ; Soto, L; Pesce, B; Molina, MC; Cuchacovich, M; Larrondo, ML; Neira, Ó; Catalán, DF; Hilkens, CM; Thomas, R; Verdugo, RA; Aguillón, JC. Article ISI Front Immunol. (2016)
Gene Expression Profiling of Human Monocyte-derived Dendritic Cells - Searching for Molecular Regulators of Tolerogenicity. Schinnerling, K; García-González, P; Aguillón, JC. Article ISI FRONTIERS IN IMMUNOLOGY (2015)
Neuropilin-1(+) regulatory T cells promote skin allograft survival and modulate effector CD4(+) T cells phenotypic signature Campos-Mora, M; Morales, R. A.; Pérez F.; Gajardo, T; Campos J.; Catalan, D; Aguillon, J.C.; Pino-Lagos, K Article ISI SCOPUS IMMUNOLOGY AND CELL BIOLOGY (2015)
Rapamycin-conditioned dendritic cells activated with monophosphoryl lipid A promote allograft acceptance in vivo Campos-Acuna, J; Pérez F.; Narvaez, E; Campos-Mora, M; Gajardo, T; Catalan, D; Aguillón JC; Pino-Lagos, K Article ISI SCOPUS Immunotherapy (2015)
Retinaldehyde dehydrogenase activity is triggered during allograft rejection and it drives Th1/Th17 cytokine production Morales, RA; Campos-Mora, M; Gajardo, T; Pérez F.; Campos J.; Aguillón JC; Pino-Lagos, M Article ISI SCOPUS Immunobiology (2015)
Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis. Schinnerling, K; Soto, L; García-González, P; Catalán, D; Aguillón, JC. Article ISI AUTOIMMUNITY REVIEWS (2015)
Systemic sclerosis patients present alterations in the expression of molecules involved in B-cell regulation Soto L.; Ferrier, A; Aravena, O; Fonseca, E; Berendsen, J; Biere, A; Bueno, D.; Ramos, V; Aguillón JC; Catalan, D Article ISI SCOPUS Frontiers in immunology (2015)
Therapeutic potential of hyporesponsive CD4(+) T cells in autoimmunity Maggi, J; Schafer, C.; Ubilla-Olguin, G; Catalan, D; Schinnerling, K; Aguillón JC Article ISI SCOPUS Frontiers in immunology (2015)
Clinical parameters and biomarkers for anti-TNF treatment prognosis in rheumatoid arthritis patients. Cuchacovich, M; Bueno, D; Carvajal, R; Bravo, N; Aguillón, JC; Catalán, D; Soto, L. Article ISI CLINICAL RHEUMATOLOGY (2014)
Tolerogenic dendritic cells derived from donors with natural rubber latex allergy modulate allergen-specific T-cell responses and IgE production. Escobar, A; Aguirre, A; Guzmán, MA; González, R; Catalán, D; Acuña-Castillo, C; Larrondo, M; López, M; Pesce, B; Rolland, J; O'Hehir, R; Aguillón, JC. Article ISI PLOS ONE (2014)
A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines. García-González, P; Morales, R; Hoyos, L; Magg, J; Campos, J; Pesce, B; Gárate, D; Larrondo, M; Gonzalez, R; Soto, L; Ramos, V; Tobar, P; Molina, MC; Pino-Lagos, K; Catalán, D; Aguillón, JC. Article JOURNAL OF TRANSLATIONAL MEDICINE (2013)
Blocking of p38 and transforming growth factor ss receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis Garate, D; Rojas-Colonelli, N; Peña C; Salazar, L; Abello P; Pesce B,; Aravena, O; Garcia-Gonzalez, P; Ribeiro, CH; Molina, MC; Catalan, D; Aguillón JC Article ISI SCOPUS Arthritis and Rheumatism (2013)
Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells Peña C; Garate, D; Contreras-Levicoy, J; Aravena, O; Catalan, D; Aguillón JC Article ISI SCOPUS Clinical and Developmental Immunology (2013)
Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients Pesce B,; Soto L.; Sabugo, F; Wurmann, P; Cuchacovich M.; López MN; Sotelo, PH; Molina, MC; Aguillón JC; Catalan, D Article ISI SCOPUS Clinical and Experimental Immunology (2013)
An efficient method for variable region assembly in the construction of scFv phage display libraries using independent strand amplification Sotelo, P.H.; Collazo, N.; Zúñiga R.; Gutierrez-Gonzalez M.; Catalan, D; Ribeiro, C.H.; Aguillon, J.C.; Molina, M. C. Article ISI SCOPUS mAbs (2012)
Weak CD4+ T-cell responses to citrullinated vimentin in rheumatoid arthritis patients carrying HLA-DR9 alleles Catalan, D; Aravena, O; Zúñiga R.; Silva N.; Escobar A.; Sabugo, F; Wurmann, P; Soto L.; González R.; Alfaro, J; Larrondo M.; Cuchacovich M.; Aguillon, J.C. Article ISI SCOPUS Rheumatology International (2012)
A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-beta plus tolerogenic dendritic cells López MN; Pesce B,; Kurte, M; Pérez, C.; Segal G; Roa, J; Aguillón JC; Mendoza-Naranjo, A; Gesser B; Larsen C.; Villablanca A.; Choudhury A.; Kiessling R.; SALAZAR ONFRAY F Article ISI SCOPUS Immunobiology (2011)
Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-γ-producing NK cell and regulatory T cell subsets. Aravena, O; Pesce, B; Soto, L; Orrego, N; Sabugo, F; Wurmann, P; Molina, MC; Alfaro, J; Cuchacovich, M; Aguillón, J; Catalán, D. Article IMMUNOBIOLOGY (2011)
Interleukin 10 decreases MICA expression on melanoma cell surface Serrano A.E.; Menares-Castillo, E; Garrido-Tapia, M; Ribeiro, C.H.; Hernandez, C.J.; Gatica-Andrades, M; Valenzuela-Diaz R; Ziga R.; López, M N.; SALAZAR ONFRAY F; Aguillon, J.C.; Molina, M. C.; Mendoza-Naranjo, A Article ISI SCOPUS Immunology and Cell Biology (2011)
Levels of Interleukin-21 in Patients With Untreated Chronic Periodontitis Dutzan N.; Rivas, C; Garcia-Sesnich, J; Henriquez L.; Rivera O.; Dezerega, A; Hernandez, M.; Silva N.; Aguillón JC; Puente J.; Vernal, R; Gamonal, J Article ISI SCOPUS Journal of Periodontology (2011)
The presence of anti-citrullinated protein antibodies (ACPA) does not affect the clinical response to adalimumab in a group of RA patients with the tumor necrosis factor (TNF) alpha-308 G/G promoter polymorphism Soto L.; Sabugo, F; Catalan, D; Wurmann, P; Cermenatti T.; Gatica H.; Aravena, O; Salazar, L; Aguillón JC; Cuchacovich M. Article ISI SCOPUS Clinical Rheumatology (2011)
B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and Fc gamma RIIb, which are modulated by anti-tumor necrosis factor therapy Catalan, D; Aravena, O; Sabugo, F; Wurmann, P; Soto L.; Kalergis, AM; Cuchacovich M.; Aguillón JC Article ISI SCOPUS Arthritis Research and Therapy (2010)
Presencia de Linfocitos T Reguladores en Periodontitis Crónica Carré, L; Franco, ME; Henriquez L.; Garcia-Sesnich, J; Dutzan N.; Aguillón JC; Gamonal, J Article SCIELO REVISTA CLINICA DE PERIODONCIA, IMPLANTOLOGIA Y REHABILITACION ORAL (2010)
Levels of Interferon-Gamma and Transcription Factor T-Bet in Progressive Periodontal Lesions in Patients With Chronic Periodontitis Dutzan N.; Vernal, R; Hernandez, M.; Dezerega, A; Rivera O.; Silva N.; Aguillón JC; Puente J.; Pozo, P; Gamonal, J Article ISI SCOPUS JOURNAL OF PERIODONTOLOGY (2009)
Basal anti-cyclic citrullinated peptide (anti-CCP) antibody levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab in rheumatoid arthritis Cuchacovich M.; Catalan, D; Wainstein E.; Gatica H.; Soto L.; Aravena, O; Pesce B,; Sabugo, F; Aguillón JC Article ISI SCOPUS CLINICAL AND EXPERIMENTAL RHEUMATOLOGY (2008)
Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells Silva N.; Dutzan N.; Hernandez, M.; Dezerega, A; Rivera O.; Aguillón JC; Aravena, O; Lastres, P; Pozo, P; Vernal, R; Gamonal, J Article ISI SCOPUS JOURNAL OF CLINICAL PERIODONTOLOGY (2008)
Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated dendritic cells Salazar, L; Aravena, O; Abello P; Escobar A.; Contreras-Levicoy, J; Rojas-Colonelli, N; Catalan, D; Aguirre A.; Zúñiga R.; Pesce B,; González C; Cepeda R.; Cuchacovich M.; Molina, MC; SALAZAR ONFRAY F; Delgado M.; Toes, RE; Aguillón JC Article ISI SCOPUS ANNALS OF THE RHEUMATIC DISEASES (2008)
Inflammation, synovial angiogenesis and chondroid apoptosis in the evolution of type II collagen-induced arthritis González C; Abello P; Cepeda R.; Salazar, L; Aravena, O; Pesce B,; Catalan, D; Aguillón JC Article ISI SCOPUS European Cytokine Network (2007)
Short-term lipopolysaccharide stimulation indeces differentiation of murine bone marrow-derived dentritic cells into tolerogenic phenotype Salazar, L; Aravena, O; Contreras-Levicoy, J; Pesce B,; Catalan, D; Zúñiga R.; Iruretagoyena M.; Kalergis, AM; Aguillón JC Article ISI SCOPUS European Cytokine Network (2007)
Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution? Aguillón JC; Cruzat, A Article IMMUNOBIOLOGY (2006)
NOD2/CARD15 and Toll-like 4 receptor gene polymorphism in Chilean patients with inflammatory bowel disease Figueroa C.; Peralta, A; Herrera L.; Castro P. ; Gutierrez A.; Valenzuela J.; Aguillón JC; Quera, R; Hermosa, MA Article ISI SCOPUS European Cytokine Network (2006)
The role of regulatory T lymphocytes in the induced immune response mediated by biological vaccines. López M; Aguilera R.; Pérez C; Mendoza-Naranjo, A.; Pereda, C; Ramirez M.; Ferrada C.; Aguillón JC Article IMMUNOBIOLOGY (2006)
Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis. Cuchacovich, M., Soto, L., Edwardes, M., Gutierrez, M., Llanos, C., Pacheco, D., Sabugo, F., Alamo, M., Fuentealba, C., Villanueva, L., Gatica, H., Schiattino, I., Salazar, L., Catalan, D., Valenzuela, O., Salazar-Onfray, F., Aguillón, J.C. Article Scand J Rheumatol. (2006)
Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis Mavropoulos, JC; Cuchacovich M.; Llanos, C.; Aguillón JC; Gatica H.; Pizzo, SV; Gonzalez-Gronow, M Article ISI JOURNAL OF RHEUMATOLOGY (2005)
Emergent therapies for rheumatoid arthritis Aguillón, JC; Cruzat, A; Contreras-Levicoy, J; Dotte, A; Pesce, B; Aravena, O; Salazar, L; Catalán, D; Abello, P; Aguirre, A; Llanos, C; Cuchacovich, M Article Rev Med Chil (2005)
Emergent therapies for rheumatoid arthritis. Aguillón, JC; Cruzat, A; Contreras-Levicoy, J; Dotte, A; Pesce, B; Aravena, O; Salazar, L; Catalán, D; Abello, P; Aguirre, A; Llanos, C; Cuchacovich, M. Article ISI REVISTA MEDICA DE CHILE (2005)
Multiple imputation procedures allow the rescue of missing data: An application to determine serum tumor necrosis factor (TNF) concentration values during the treatment of rheumatoid arthritis patients with anti-TNF therapy Schiattino, I; Villegas, R; Cruzat, A; Cuenca J.; Salazar, L; Aravena, O; Pesce B,; Catalan, D; Llanos, C.; Cuchacovich M.; Aguillón JC Article ISI SCIELO SCOPUS BIOLOGICAL RESEARCH (2005)
Papel de los polimorfismos -238 y -308 del promotor del factor de necrosis tumoral alfa en la patogenia y respuesta al tratamiento anti- factor de necrosis tumoral alfa en artritis reumatoide Carolina Llanos M; Lilian Soto S; Francisca Sabugo S; M Jos Bast; Lorena Salazar A; Juan C Aguill; Miguel Cuchacovich T Article SCIELO REVISTA MEDICA DE CHILE (2005)
A simple immunometric assay to assess the feeding habits of Meprai spinolai, a Trypanosoma cruzi vector Molina, MC; Cattaan, P; Canals M.; Cruzat, L.; Aguillón JC; Ferreira A. Article ISI SCOPUS PARASITOLOGY RESEARCH (2004)
A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and transporter associated with antigen processing 1/2 in human melanoma cells Kurte, M; Lopez M.; Aguirre A.; Escobar A.; Aguillón JC; Charo, J; Larsen, CG; Kiessling R.; SALAZAR ONFRAY F Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2004)
The -308 polymorphism in the promotor region of the tumor necrosis factor-alpha (TNF-alpha) gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggresive peridontitis and/or type 1 diabetes mellitus Pérez, C.; Gonzalez, FE; Pavez, V; Araya, AV; Aguirre A.; Cruzat, A; Contreras-Levicoy, J; Dotte, A; Aravena, O; Salazar, L; Catalan, D; Cuenca J.; Ferreira A.; Schiattino, I; Aguillón JC Article ISI European Cytokine Network (2004)
Tumour necrosis factor-alpha (TNF-alpha) levels and influence of 2308 TNF-alpha promoter polymorphism on the responsiveness to infliximab in patients with rheumatoid arthritis Cuchacovich M.; Ferreira L.; Aliste, M; Soto L.; Cuenca J.; Cruzat, A; Gatica H.; Schiattino, I; Pérez, C.; Aguirre A.; SALAZAR ONFRAY F; Aguillón JC Article ISI SCOPUS SCANDINAVIAN JOURNAL OF RHEUMATOLOGY (2004)
An anti-human recombinant tumor necrosis factor alpha (TNF alpha) monoclonal antibody recognizes an epitope in feline TNF alpha Aguirre A.; Escobar A.; Ferreira, V; Molina, MC; Ferreira A.; Aguillón JC Article ISI VETERINARY RESEARCH (2003)
Ex vivo lipopolysaccharide (LPS)-induced TNF-alpha, IL-1 beta, IL-6 and PGE(2) secretion in whole blood from Type 1 diabetes mellitus patients with or without aggressive periodontitis Araya, AV; Pavez, V; Pérez, C.; González F; Colombo, A; Aguirre A.; Schiattino, I; Aguillón JC Article ISI European Cytokine Network (2003)
New immunological weapons for medicine in the 21st Century: biological therapy based on the use of the latest generation monoclonal antibodies Aguillón, JC; Contreras, J; Dotte, A; Cruzat, A; Catalán, D; Salazar, L; Molina, MC; Guerrero, J; López, M; Soto, L; Salazar-onfray, F; Cuchacovich, M Article Rev Med Chil (2003)
The -308 polymorphism in the tumour necrosis factor (TNF) gene promoter region and ex vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in Chilean patients with rheumatoid arthritis Cuenca J.; Cuchacovich M.; Pérez, C.; Ferreira L.; Aguirre A.; Schiattino, I; Soto L.; Cruzat, A; SALAZAR ONFRAY F; Aguillón JC Article ISI SCOPUS RHEUMATOLOGY (2003)
Tumor necrosis factor alpha genetic polymorphism as a risk factor in disease Aguillón JC; Cruzat, A; Cuenca J.; Cuchacovich M. Article ISI REVISTA MEDICA DE CHILE (2002)
Daily production of human tumor necrosis factor in LPS-stimulated ex vivo blood culture assays Aguillón JC; Escobar A.; Ferreira, V; Aguirre A.; Ferreira L.; Molina, MC; Ferreira A. Article ISI SCOPUS European Cytokine Network (2001)
Genetic polymorphism at position-308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population Cuenca J.; Perez, CA; Aguirre, AJ; Schiattino, I; Aguillón JC Article ISI SCIELO BIOLOGICAL RESEARCH (2001)
Development of an immunoenzymatic assay for the detection of human antibodies against Trypanosoma cruzi calreticulin, an immunodominant antigen Marcelain, K; Colombo, A; Molina, MC; Ferreira L.; Lorca M.; Aguillón JC; Ferreira A. Article ISI SCOPUS ACTA TROPICA (2000)
Tc45, a dimorphic Trypanosoma cruzi immunogen with variable chromosomal localization, is calreticulin Aguillón JC; Ferreira L.; Pérez, C.; Colombo, A; Molina, MC; Wallace A.; Solari, A; Carvallo, P.; Galindo, M; Galanti N.; Orn, A; Billetta, R; Ferreira A. Article ISI AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2000)
Trypanosoma cruzi: H2 complex and genetic background influence on the humoral immune response against epimastigotes Aguillón JC; Hermosilla T.; Molina, MC; Morello A.; Repetto Y; Orn, A; Ferreira A. Article ISI SCOPUS INTERNATIONAL JOURNAL FOR PARASITOLOGY (2000)
Immunization with bacterial antigens: piscirickettsiosis Smith, PA; Contreras JR; Larenas JJ; Aguillón JC; Garcés LH; Pérez B; Fryer JL Article Developments in Biological Standardization (1997)
Immunodiagnosis of fasciolosis in horses and pigs using Western blots Gorman T.; Aballay, J; Fredes, F; Silva M.; Aguillon, J.C.; Alcaino H.A. Article INTERNATIONAL JOURNAL FOR PARASITOLOGY (1997)
Recognition of an immunogenetically selected Trypanosoma cruzi antigen by seropositive chagasic human sera Aguillon, J.C.; Molina, M. C.; Colombo, A; Cortes C.; Hermosilla T.; Carreño P.; Ferreira A.; Harris R.; Orn, A Article ACTA TROPICA (1997)
Immunomodulation of LPS ability to induce the local Shwartzman reaction Aguillon, J.C.; Ferreira, V; Núñez E.; Paredes, L.; Molina, M. C.; Colombo, A; Hermosilla T.; Ferreira A. Article SCANDINAVIAN JOURNAL OF IMMUNOLOGY (1996)
Humoral immune response anti K99 pilus from enterotoxigenic Escherichia coli in experimentally inoculated calves Bustos C.; Zurita, L; Smith P.; Vallejos P.; Aguillón JC; López M; Ferreira A. Article BIOLOGICAL RESEARCH (1995)
Purification and Preliminary Sequencing of Tc45, an Immunodominant Trypanosoma cruzi Antigen: Absence of Homology with Cruzipain, Cruzain, and a 46-Kilodalton Protein. Aguillón, J.C.,... Ferreira A. Article ISI AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (1995)
Radiolabeling of Small Peptides Bound to a Solid Phase. Maass, R.,...Ferreira, A. Article ISI ANALYTICAL BIOCHEMISTRY (1995)
A Simple Method for Negative and Positive Selection of Murine and Human IgM-Bearing Lymphocytes Based on the Use of Antibody-Coated Silica Microparticles Seeger M., ... Ferreira A. Article ISI JOURNAL OF IMMUNOLOGICAL METHODS (1993)
An Immunogenetically Defined and Immunodominant Trypanosoma cruzi Antigen Ramos, R., ..., Ferreira A. Article ISI AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (1991)
Octadecyl silica: A solid Phase for Protein Purification by Immunoadsorption Chiong M., ... Ferreira, A. Article ISI ANALYTICAL BIOCHEMISTRY (1991)


In Vitro Generated Human Dendritic Cells Exposed to a Potent Maturation Melanoma Cell Lines Lysate Show a Tolerogenic-like Phenotype and Functionality When Exposed to Dexamethasone Prior to the Maturation Stimuli Falcon-Beas, C; Tempio F.; Pesce B,; Aguillon, J.; Pereda, C; Saffie C; SALAZAR ONFRAY F; López MN Abstract ISI EUROPEAN JOURNAL OF CANCER (2012)
ANTI-TNF THERAPY INDUCES CHANGES ON T CELLS AND NK CELLS SUB-POPULATIONS IN RHEUMATOID ARTHRITIS PATIENTS Catalán DF; Pesce B,; Aravena, O; Orrego, N.; Soto L.; Sabugo, F; Wurmann, P; Cuchacovich M.; Aguillón JC Abstract ISI CLINICAL AND EXPERIMENTAL RHEUMATOLOGY (2011)
Adalimumab, a Tumor Necrosis Factor Blockade Therapy, Decreases Th1 and Th17 Populations in Rheumatoid Arthritis Patients Pesce B,; Catalan, D; Orrego, N.; Aravena, O; Soto L.; Wurman, P; Sabugo, F; Cuchacovich M.; Aguillon, J. Abstract ISI CLINICAL IMMUNOLOGY (2010)
Dexamethasone Pretreatment Followed by an Inoculation of Short-term Lipopolysaccharide-stimulated Dendritic Cells Improves the Response of Murine Collagen-induced Arthritis Aguillon, J.; Pena M.; Catalan, D; Aravena, O; Rojas-Colonelli, N; Garate, D Abstract ISI CLINICAL IMMUNOLOGY (2010)
Dexamethasone Treated Monocyte-dendritic Cells from Latex Allergy Patients Induce Tolerance to the Major Allergen Hev b 5 Escobar A.; Guzman, MA; Aguillon, J. Abstract ISI CLINICAL IMMUNOLOGY (2009)
Regulation of NKG2D ligand expression by IL-10 Serrano, AE; Gatica-Andrades, M; Menares-Castillo, E; Garrido M.; Hernandez C.; López MN; SALAZAR ONFRAY F; Aguillón JC; Molina, MC Abstract ISI CYTOKINE (2008)
Basal anti-cyclic citrullinated peptide (anti-ccp) antibodies levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab therapy in rheumatoid arthritis patients Cuchacovich M.; Catalan, D; Wainstein E.; Gatica H.; Soto L.; Aravena, O; Pesce B,; Sabugo, F; Aguillon, J. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2007)
Established murine collagen-induced arthritis and IL-17 production are specifically inhibited by a single inoculation of lipopolysaccharide-stimulated dendritic cells Aguillón JC; Salazar, L; Araveno, O; González C; Abello P; Contreras-Levicoy, J; Pesce B,; SALAZAR ONFRAY F; Cuchacovich M. Abstract ISI CLINICAL IMMUNOLOGY (2007)
Tumor necrosis factor-alpha levels gurrelate with a better response to adalimumab in patients with rheumatoid arthritis Cuchacovich M.; Soto L.; Gutiérrez M; Llanos, C.; Sabugo, F; Pacheco, D. ; Alamos, M.; Fuentealba, C; Villanueva, L; Gatica H.; Schiattino, I; Salazar, L; Catalan, D; Valenzuela O.; SALAZAR ONFRAY F; Aguillon, J. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2006)
Dendritic cells pulsed with type II bovine collagen modulate the murine collagen induced arthritis. Salazar, LE; Aravena, OA; Abello P; Aguirre A.; Catalan, D; Llanos, C.; Sabugo, F; González F; González C; Cuchacovich M.; Aguillón JC Abstract ISI CLINICAL IMMUNOLOGY (2005)
Ex vivo pro-inflammatory cytokines expression in patients with aggressive periodontitis. Gonzalez, FE; Catalan, D; Aguillón JC Abstract ISI CLINICAL IMMUNOLOGY (2005)
Rapid protocol to generate tolerogenic dendritic cells using microbial lipopeptide (BLP). Aravena, OA; Salazar, L; Mass, C; Aguirre A.; Catalan, D; Hermoso, M; Aguillón JC Abstract ISI CLINICAL IMMUNOLOGY (2005)
TNF-alpha-308 G/G promoter polymorphism correlates with a better response to adalimumab in patients with rheumatoid arthritis Cuchacovich M.; Soto L.; Edwardes, M; Suissa, S; Gutiérrez M; Llanos, C.; Sabugo, F; Pacheco, D. ; Alamo, M; Fuentealba, C; Villanueva, L; Gatica H.; Salazar, L; Valenzuela O.; Salazar F.; Aguillon, J. Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2005)
Tumor necrosis factor genetic polymorphism as part of rheumatoid arthritis evolution Cruzat, A; Schiattino, I; Cuchacovich M.; Aguillón JC Abstract ISI CLINICAL IMMUNOLOGY (2005)
Tumor necrosis factor-alpha-308 G/G promoter polymorphism correlates with a better response to adalimumab in patients with rheumatoid arthritis. Cuchacovich M.; Soto L.; Edwardes, M; Gutiérrez M; Llanos, C.; Pacheco, D. ; Sabugo, F; Alamo, M; Fuentealba, C; Villanueva, L; Gatica H.; Schiattino, I; Salazar, L; Catalan, D; Valenzuela O.; SALAZAR ONFRAY F; Aguillón JC Abstract ISI ARTHRITIS AND RHEUMATISM (2005)


How we can improve the predictive value of prognostic biomarkers in rheumatoid arthritis Soto L.; Catalan, D; Aguillon, J.C.; Cuchacovich M. Editorial SCOPUS International Journal of Clinical Rheumatology (2015)


Anticuerpo monoclonal contra TNF humano y sus fragmentos; secuencia nucleotídicas que lo codifica, vector y célula que la contienen; composiciones y kit que comprenden el anticuerpo; uso de los mismos y método para su obtención Aguillón, Juan Carlos; Molina, María Carmen Patent WO2011083175 (2014)
Promotor con región rica en dinucleótidos, citosina-guanina, vectores, líneas celulares, procedimiento para producir proteína recombinante Aguillón, Juan Carlos; Molina, María Carmen; Zúñiga, Roberto; Gutiérrez, Matías; Collazo, Norberto; Teneb, Jaime Patent


Autoantigenic peptides presented by tolerogenic dendritic cells: a personalized therapy to reinstruct the immune system of patients with rheumatoid arthritis. Aguillon, JC; Soto, L; Aravena, Octavio, Schinnerling, K. Proyecto (0)
Citometría multiparamétrica para la identificación de determinantes moleculares en células involucradas en enfermedades prevalentes en Chile Ferreira, Arturo; Aguillón, Juan Carlos; Carreño, Leandro; Hermoso, Marcela; Naves, Rodrigo; López, Mercedes; Catalán, Diego; Soto, Lilian Proyecto (0)
Desarrollo, producción y caracterización de anticuerpo recombinante humano contra MIC-A con potencial terapéutico para el tratamiento de cáncer gástrico Molina, María Carmen; Aguillón, Juan Carlos; Ribeiro, Carolina Proyecto (0)
Identifying immunodominant T-cell antigen-peptides and T-cell responses in rheumatoid arthritis: A further step in the development of an antigen-specific dendritic cell-based therapy to restore self-tolerance Aguillón, Juan Carlos; Soto, Lilian; Catalán, Diego; Neira, Oscar Proyecto (0)
Instituto Milenio en inmunología e inmunoterapia Kalergis, Alexis; Aguillón, Juan Carlos; Salazar, Flavio; López, Mercedes; Michea, Luis; Galindo, Mario; López, Marcelo; Fardella, Carlos; Bueno, Susan; Melo, Francisco; Riedel, Claudia Proyecto (0)
International research network on characterization of new therapeutic targets for rheumatoid artritis. Aguillon, JC; Tomas, R; Jaraquemada, D; Mauri, C; Catalán, D Proyecto (0)
Pre-clinical evaluation and registration of tolerogenic dendritic cells pulsed with autoantigenic peptides (TOLDeC-AP) for antigen-specific immunotherapy of rheumatoid arthritis Aguillon, JC; Soto, Lilian, Aravena, Octavio, Schinnerling, K Proyecto (0)
Péptidos autoantigénicos presentados por células dendríticas tolerogénicas: una terapia personalizada para reinstruir el sistema inmune de pacientes con artritis reumatoide Aguillón, Juan Carlos; Catalán, Diego; Soto, Lilian; Schinnerling, Katina; Aravena, Octavio Proyecto (0)
Searching for a validated cell-based therapeutic approach for the treatment of rheumatoid arthritis: Identification of specific tolerance markers and characterization of monophosphoryl lipid A (MPLA)-activated tolerogenic dendritic cells (MPLA-tDCs) Aguillón, Juan Carlos; Catalán, Diego; Soto, Lilian; Verdugo, Ricardo; Schinnerling, Katina Proyecto (0)

104

JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Diego Catalán

Associate Professor

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

OCTAVIO ARAVENA

Director Científico

I+D+i

MEDICEL SA

Santiago, Chile

MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

Bárbara Pesce

Profesora Asistente

ICBM

Universidad de Chile

Santiago, Chile

Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Lorena Salazar

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Lampa, Chile

Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Roberto Zúñiga

Investigador Asociado a Proyectos

Programa Disciplinario de Inmunologia

Universidad de Chile/ Facultad de Medicina

Santiago, Chile

Maria Sabugo

Medico Reumatologo

Medicina

UNIVERSIDAD DE CHILE HOSPITAL CLÍNICO

Santiago, Chile

Carolina Llanos

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Rolando Vernal

Profesor Titular

Departamento de Odontología Conservadora

UNIVERSIDAD DE CHILE

Santiago, Chile

Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

Pamela Wurmann

reumatologa

medicina

universidad de chile

santiago, Chile

Paula Abello

Jorge Gamonal

PROFESOR TITULAR

ODONTOLOGIA CONSERVADORA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Jorge Gamonal

Académico

Odontología Conservadora

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

Emma Hernandez

Académico 44 h, profesor titular

Oral Patology and Medicine

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

Katina Schinnerling

Profesor Asistente

Departamento de Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Karina Pino

Group Leader/Associate Professor

Centro de Investigación Biomédica

Universidad de los Andes

Santiago, Chile

Mauricio Campos Mora

Ph.D student

Universidad de Chile

Santiago, Chile

Ricardo Verdugo

Asistant Professor

Facultad de Medicina

UNIVERSIDAD DE CHILE

Santiago, Chile

Nicolás Dutzan

Associate Professor

Facultad de Odontología

Universidad de Chile

Santiago, Chile

Norberto Collazo

Business Developer

Center for Sustainable Biotechnology

Fraunhofer Chile Research

Santiago, Chile

Fermín González

Profesor Asociado

Odontología Conservadora

Universidad de Chile

Santiago, Chile

Javier Campos

Gestor de Propiedad Intelectual

Universidad Tecnológica Metropolitana

Santiago, Chile

Patricia Pozo

Académico

Ciencias Farmacéuticas

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

Mónica Kurte

Investigador

Laboratorio de Inmunologìa

Universidad de los Andes

Santiago, Chile

Carolina Ribeiro

Assistant Professor

Immunology Program

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

Marcela Gatica

Coordinadora

Decanatura Facultad de Ciencias

Universidad de La Serena

La Serena, Chile

Paulina García

Investigador Postdoctoral

Programa de Inmunologia

Universidad de Chile

Santiago, Chile

Matias Gutiérrez

Investigador

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Rodrigo Valenzuela

Bioquímico

Hematologia

Hospital del Salvador

Santiago, Chile

Julio Berrios

Académico Full-time

Facultad de Ingeniería

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

Hector Contreras

Academico

Oncologia Basico Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

Antonio Serrano

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Luis Mercado

Profesor Titular

Instituto de Biología

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

pedro cattan

full professor

ciencias biologicas animales

UNIVERSIDAD DE CHILE; FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

santiago, Chile

Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

Veronica Ramos

Bioquímico

Inmunologia, VIH y Alergias

Hospital Clínico Universidad de Chile

Santiago, Chile

Claudia Altamirano

Profesor Titular

Facultad de Ingeniería

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaíso, Chile

Daniel Bueno

Médico

Servicio de Salud metropolitano Sur

Santiago, Chile

Rodrigo Quera

Gastroenterólogo

Gastroenterología

CLÍNICA LAS CONDES, SERVICIO DE GASTROENTEROLOGÍA

Santiago, Chile

Luisa Herrera

Profesor Asociado

Incstituto de Ciencias Biomédicas, Programa de Genética Humana

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA-ICBM

Santiago, Chile

Mauricio Canals

PROFESOR TITULAR

MEDICINA

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

SANTIAGO, Chile

Rodrigo Morales

Postdoctoral researcher

Dept. of Medicine Solna (MedS)

Karolinska Institutet

Stockholm, Suecia

Roberto Díaz

Docente e Investigador

UNIVERSIDAD AUTONOMA DE CHILE

Talca, Chile

Jordi Olloquequi

Profesor Titular

Instituto de Ciencias Biomédicas

UNIVERSIDAD AUTONOMA DE CHILE

Talca, Chile

José Suazo

Profesor Asociado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

Katherine Marcelain

Profesora Asociada

Oncología Básico Clínica

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA

Santiago, Chile

Norbel Galanti

Full Professor

ICBM

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE BIOLOGÍA CELULAR Y MOLECULAR

Santiago, Chile

Rodrigo Villegas

Jefe Programa de Bioestadística

Bioestadística

Universidad de Chile - Facultad de Medicina

Santiago, Chile

JUAN CARLOS AGUILLON GUTIERREZ

Líneas de Investigación

Educación

Biochemist, UNIVERSIDAD DE CONCEPCION. Chile, 1986

Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2006

Biochemistry, UNIVERSIDAD DE CONCEPCION. Chile, 1986

Experiencia Académica

ASSISTANT PROFESSOR Full Time

ASSOCIATE PROFESSOR Full Time

PROFESSOR Full Time

CHAIRMAN Full Time

Experiencia Profesional

Full Professor Full Time

Chairman of Immunology Program Full Time

Associate Professor Full Time

Assistant Professor Full Time

Instructor Full Time

Formación de Capital Humano

Article (77)

Abstract (15)

Editorial (1)

Patent (2)

Proyecto (9)