Man

Carolina Carolina Llanos Muñoz

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that mainly affects young women. In our group we are interested in understanding the immunological mechanisms leading to the emergence and development of this disease.

Educación

  •  Medical, Universidad de Chile. Chile, 2000
  •  Internal Medicine, Universidad de Chile. Chile, 2005
  •  Clinical Immunology and Rheumatology, Pontificia Universidad Católica de Chile. Chile, 2012

Experiencia Académica

  •   Assistant Professor Full Time

    Pontificia Universidad Católica de Chile

    Facultad de Medicina

    Santiago, Chile

    Enero 2012 - A la fecha

  •   Associate Research Full Time

    New York University

    Medicine

    New York, Estados Unidos

    Enero 2009 - Enero 2010

  •   Investigador Adjunto Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    Enero 2009 - Enero 2010

Experiencia Profesional

  •   Chair Full Time

    Departamento Inmunología Clínica y Reumatología, Escuela de Medicina; P. Universidad Católica de Chile

    Santiago, Chile

    Enero 2014 - A la fecha

Formación de Capital Humano


Biochemistry Thesis, student Fabián Vega Tapia Pontificia Universidad Católica de Valparaíso, Advisor
Research Seminar of Biochemistry student Cristian Figueroa Parada, Pontificia Universidad Católica de Chile, Advisor.


Premios y Distinciones

  •   Basic Science Award

    S.L.E. Foundation Inc, New York

    Estados Unidos, 2006

    Basic Science Award for the Project: "Impaired clearence of apoptotic cardiocytes and pathogenesis of Congenital Heart Block: link to SSA/Ro-SSB/La antibodies". Mentor: Jill Buyon, MD.


 

Article (23)

Carbon monoxide exposure improves immune function in lupus-prone mice
Anatomical and pathological findings in hearts from fetuses and infants with cardiac manifestations of neonatal lupus
Haem oxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus
Heme oxygenase-1 expression were decreased in monocytes from Systemic Lupus Erithematosus patients
Maternal Use of Hydroxychloroquine Is Associated With a Reduced Risk of Recurrent Anti-SSA/Ro-Antibody-Associated Cardiac Manifestations of Neonatal Lupus
Association of the Idiotype: Antiidiotype Antibody Ratio With the Efficacy of Intravenous Immunoglobulin Treatment for the Prevention of Recurrent Autoimmune-Associated Congenital Heart Block
Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity
Maternal and Fetal Factors Associated With Mortality and Morbidity in a Multi-Racial/Ethnic Registry of Anti-SSA/Ro-Associated Cardiac Neonatal Lupus
Cutaneous manifestations of neonatal lupus and risk of subsequent congenital heart block.
Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: Results of a multicenter, prospective, open-label clinical trial
Evaluation of the risk of anti-SSA/Ro-SSB/La antibody-associated cardiac manifestations of neonatal lupus in fetuses of mothers with systemic lupus erythematosus exposed to hydroxychloroquine.
Recurrence rates of cardiac manifestations associated with neonatal lupus and maternal/fetal risk factors.
Antibody reactivity to alpha-enolase in mothers of children with congenital heart block.
Prospective evaluation of fetuses with autoimmune-associated congenital heart block followed in the PR Interval and Dexamethasone Evaluation (PRIDE) Study.
Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum
Systemic vasculitis associated with Fasciola hepatica infection
Tumour necrosis factor (TNF)alpha-308 G/G promoter polymorphism and TNF alpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis
Anti-tumor necrosis factor-? therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis
Anti-tumor necrosis factor-alpha therapy augments dipeptidyl peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis
Multiple imputation procedures allow the rescue of missing data: An application to determine serum tumor necrosis factor (TNF) concentration values during the treatment of rheumatoid arthritis patients with anti-TNF therapy
Rituximab (anti-CD20 monoclonal antibody) for refractory systemic lupus erythematosus. Report of one case
THE INFLUENCE OF -238 AND -308 TNF ALPHA POLYMORPHISMS ON THE PATHOGENESIS AND RESPONSE TO TREATMENT IN RHEUMATOID ARTHRITIS
Heme Oxygenase-1 as a Target for the Design of Gene and Pharmaceutical Therapies for Autoimmune Diseases

Abstract (6)

Anatomic and Pathologic Findings in Hearts from Fetuses and Infants with Cardiac Manifestations of Neonatal Lupus
Dendritic cells pulsed with type II bovine collagen modulate the murine collagen induced arthritis.
TNF-alpha-308 G/G promoter polymorphism correlates with a better response to adalimumab in patients with rheumatoid arthritis
Tumor necrosis factor-alpha-308 G/G promoter polymorphism correlates with a better response to adalimumab in patients with rheumatoid arthritis.
Interaction between REM sleep homeostasis, wakefulness and non-REM sleep, in sleep deprivation protocols
Length of REM sleep episodes during selective intermittent deprivation of REM sleep

Review (4)

Tolerogenic dendritic cells as a therapy for treating lupus
Genetic and Pharmacological Modulation of Dendritic Cell-T Cell Interactions as a Therapeutic Strategy for Systemic Lupus Erythematosus
Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?
Emergent therapies for rheumatoid arthritis

Letter (1)

Letter to the Editor in response to the article Preventing congenital neonatal heart block in offspring of mothers with anti-SSA/Ro and SSB/La antibodies: A review of published literature and registered clinical trials. by Gleicher N, Elkayam U, Autoimmun Rev. 2013 Sep;12(11):1039-45
36
Carolina Llanos

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

17
Carolina Llanos

Jefe de Departamento

Inmunología Clínica y Reumatología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Maria Sabugo

Medico Reumatologo

Medicina

UNIVERSIDAD DE CHILE HOSPITAL CLÍNICO

Santiago, Chile

3
Octavio Aravena

INVESTIGADOR

INSTITUTO CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

3
Leandro Carreño

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

3
Claudia Riedel

Associate Professor

Ciencias Biológicas

Universidad Andres Bello

Santiago, Chile

3
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

2
Juan Aguillón

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Lilian Soto

Rheumatologist

Medicine

CLINICAL HOSPITAL OF UNIVERSIDAD DE CHILE

Santiago, Chile

1
Susan Bueno

Profesor asociado

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Jimena Cuenca

Investigador/profesor

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

1
Rodrigo Villegas

Jefe Programa de Bioestadística

Bioestadística

Universidad de Chile - Facultad de Medicina

Santiago, Chile

1
IVAN GALLEGOS

PATHOLOGIST, LABORATORY DIRECTOR

PATHOLOGY

HOSPITAL CLINICO DE UNIVERSIDAD DE CHILE

SANTIAGO, Chile