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Marcela Alejandra Hermoso Ramello

Full Professor

UNIVERSIDAD DE CHILE

Santiago, Chile

Innate immunity; mucosal immunity; infections and inflammation; Mechanisms of Bacterial Pathogenicity (Adhesion); Molecular Epidemiology; Cellular Microbiology (Bacteria-Cell interactions); Inflammatory Bowel Disease; Gastrointestinal Disorders.

Biochemist, UNIVERSIDAD DE BUENOS AIRES. Argentina, 1987
Biological Sciences in Physiology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997

Full Professor Full Time

UNIVERSIDAD DE CHILE

Medicine

Santiago, Chile

2017 - A la fecha
ASSOCIATE PROFESSOR Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2007 - 2017

Biochemist Full Time

Hospital of the Institute of Cardiology, National Academy of Medicine, Buenos Aires, Argentina.

Buenos Aires, Argentina

1988 - 1989
PhD Student Full Time

Pontificia Universidad Catolica de Chile

Santiago, Chile

1991 - 1997
Post-doc at Dr. Joseph Hume Laboratory Full Time

Center of Biomedical Research Excellence (COBRE), School of Medicine, University of Nevada

Reno, Estados Unidos

2001 - 2001
Post-doc at Dr. John A. Cidlowski Laboratory Full Time

National Institutes of Environmental Health Sciences/National Institutes of Health, North Carolina

Chile

2002 - 2005
Founder and Head Full Time

The Innate Immunity Laboratory, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile

Santiago, Chile

2005 - 2006
Assistant Professor Full Time

Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile.

Santiago, Chile

2005 - 2006
Associate Professor Full Time

Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile

Santiago, Chile

2007 - A la fecha
Associate Professor Full Time

Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile

Chile

2007 - A la fecha
Associate Professor Full Time

Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile

Santiago, Chile

2007 - A la fecha

PhD thesis mentoring

1) Glauben Landskron Ramos: Programa de Doctorado en Ciencias Biomédicas, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Título de la Tesis: Papel del ATP extracelular en la liberación de IL33 por fibroblastos asociados a cáncer y el efecto de esta citoquina sobre la transición epitelio-mesénquima de una línea celular de adenocarcinoma colorectal. Directores: Marcela Hermoso Ramello y Guillermo Díaz. Thesis completed 2018.

2) Nayaret Chamorro: Programa de Doctorado en Microbiología, Universidad de Chile. Título de la Tesis: Caracterización de la microbiota de pacientes con enfermedades inflamatorias intestinales y su asociación con la respuesta inflamatoria. Directores: Roberto Vidal y Marcela Hermoso Ramello. Thesis completed 2019.

3) David Diaz Jiménez: Programa de Doctorado en Bioquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. Título de la Tesis: “Los Glucocorticoides Reprimen La Transcripción del Gen GR/NR3C1 Mediante Mecanismos Autoregulatorios Y Modificaciones Epigenéticas: Impacto En La Función Inflamatoria De Macrófagos Derivados de Monocitos”. Directores: Marcela Hermoso Ramello y John A. Cidlowski. Thesis completed 2019.

4) Daniela Parada. Programa de Doctorado en Ciencias Biomédicas, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Título de la Tesis: “Rol de ácidos grasos de cadena corta en el perfil de macrófagos y la reparación epitelial en enfermedades inflamatorias intestinales” . Directores: Marcela Hermoso Ramello. Thesis to be completed 2019.

5) Karen Dubois Camacho: Programa de Doctorado en Ciencias Biomédicas, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Título de la Tesis: MicroRNA 378a-3p, un nuevo regulador post-transcripcional de la variante soluble del receptor de IL33. Directores: Marcela Hermoso Ramello y Rodrigo Quera. Thesis completed 2017.

6) Mauricio Olivares Morales. Programa de Doctorado en Ciencias Biomédicas, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Título de la Tesis: Rol de los glucocorticoides en la respuesta bactericida e inflamatoria de macrófagos infectados con la cepa de E. coli intracelular asociada a Enfermedad de Crohn. Directores: Marcela Hermoso Ramello y Roberto Vidal. Thesis completed 2017.

7) Tanya Neira. Programa de Doctorado en Ciencias Biomédicas, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Título de la Tesis: Characterization of the inflammatory response mediated by PARP-1 in a rat model of perinatal asphyxia. Directores: Mario Herrera-Marschitz, Paola Morales y Marcela Hermoso. Thesis completed 2015.

8) Marjorie De la Fuente López. Programa de Doctorado en Ciencias Biomédicas, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Título de la Tesis: Escherichia coli adherente invasiva en pacientes con enfermedad de Crohn: análisis de los mecanismos de invasión y evasión en células epiteliales y macrófagos. Directores: Marcela Hermoso Ramello y Roberto Vidal. Thesis completed 2014.

9) Daniela Araya. Programa de Doctorado en Ciencias Biomédicas, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Título de la Tesis: Sistemas de captación de hierro como mecanismos de patogenicidad asociados a Escherichia coli adherente-invasiva aisladas de pacientes con Enfermedad de Crohn. Directores: Roberto Vidal y Marcela Hermoso Ramello. Candidata a doctora 2012.

10) Pedro Ayala. Programa de Doctorado en Farmacología, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. Título de la Tesis: Rol de los fibroblastos y miofibroblastos cardíacos en el proceso inflamatorio mediado por TLR4. Directores: Guillermo Díaz y Marcela Hermoso Ramello. Thesis completed 2013

11) Patricia Langjahr. Programa de Doctorado en Ciencias Biomédicas, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Título de la Tesis: Mecanismos moleculares involucrados en la producción de variantes solubles de TLR2. Director: Marcela Hermoso Ramello. Thesis completed 2013.

12) Lucia Núñez. Programa de Doctorado en Ciencias Biomédicas, Escuela de Postgrado, Facultad de Medicina, Universidad de Chile. Título de la Tesis: ST2: un nuevo mecanismo anti-inflamatorio de la acción de los glucocorticoides. Director: Marcela Hermoso Ramello. Thesis completed 2012.

13) Frano Malinarich. Biochemistry Program, Faculty of Chemistry and Pharmacy, Universidad de Chile. “Contribution of CCL4 to the oral tolerance mediated by intestinal T-gamma delta intraepithelial cells”. Thesis completed 2010.

14) Caroll Beltrán Muñoz. Biomedical Sciences Program, Faculty of Medicine, Universidad de Chile: “ST2 as an immunomodulator in inflammatory bowel diseases”. Thesis completed 2009.

Master degree direction

1) Mirit Bitran. Biochemist Program, Faculty of of Chemistry and Pharmacy, Universidad de Chile. Correlación entre la vía esteroidogénica intestinal y la respuesta al tratamiento con glucocorticoides en pacientes con colitis ulcerosa. Thesis in progress (to be graduated 2019)

2) Enzo Candia. Biological Science Program, mention immunology, Faculty of Medicine, Universidad de Chile. “Regulation of intestinal macrophages and monocytes by TLR2 in IBD”. Thesis completed 2011.

3) Maria José Herrera. Medical Science Program, mention immunology, Faculty of Medicine, Universidad de Chile. “Regulatory mechanisms of glucocorticoids on TLR4 expression in epithelium”. Thesis completed 2010.

Undergraduate thesis direction:

1) Gonzalo Vásquez: Universidad Tecnológica Metropolitana, Facultad Ciencias Naturales, Matemática Y del Medio Ambiente, Escuela de Industria Alimentaria y Biotecnología. "Producción y purificación de un scFv recombinante específico para la proteína ST2 soluble (sST2)". Thesis to be completed 2019.

2) Jonathan Lillo Barra. Universidad Tecnológica Metropolitana, Facultad Ciencias Naturales, Matemática Y del Medio Ambiente, Escuela de Industria Alimentaria y Biotecnología. "Producción de un anticuerporecombinante específico para la proteína ST2 soluble (sST2)". Thesis in progress (2019).

3) Estefhany Rubio C: Engineering in Biotechnology, Universidad Santo Tomás, Chile. “TLR2 processing by ADAMs methalloproteinases and ?-secretase complex“. Thesis completed 2013.

4) Diego Romero, Faculty of Medical Technology, Universidad de Chile. “ST2 and GRP78 expression in goblet cells in colon mucosa of ulcerative colitis patients (Expresión de ST2 y GRP78 en células caliciformes de pacientes con colitis ulcerosa).”. Thesis completed 2012.

5) Salvador Carvajal: Engineering in Biotechnology, Faculty of Sciences, Universidad de Chile. “Standardization of a capture ELISA for the measurement of soluble toll-like receptor 2 in human plasma”. Thesis completed 2010.

6) Karen Flores: Engineering in Biotechnology, Faculty of Engineering, Universidad de Chile. Thesis title: “Determination of operational parameters that allow definition of the mechanism of cell-penetrating TIRAP-Ala and TIRAP peptides internalization in HeLa cells”. Thesis completed 2010.

7) Nancy Farfán: Engineering in Biotechnology, Faculty of Sciences, Universidad de Chile. “Determination of soluble isoforms of Toll-like receptor 2 (TLR2) and characterization of its levels in plasma and biopsies from patients with inflammatory bowel disease”. Thesis completed 2013.

8) Rodrigo Valenzuela: Biochemistry, Faculty of Chemistry and Pharmacy, Universidad de Chile. Thesis title: “Participation of ST2 as a negative endogenous regulador in the TLR2 proinflammatory pathway”. Thesis completed 2008.

9) Ramón Pérez: Biochemistry, Faculty of Chemistry and Pharmacy, Universidad de Chile. Thesis title: “Transcriptional regulation of TLR4 by pro- and anti-inflammatory agents”. Thesis completed 2008.

10) Alexis Peralta: Biochemistry, Faculty of Chemistry and Pharmacy, Universidad de Chile. Thesis title: “ST2 and its relation to the immune Th1 and Th2 pattern in inflammatory bowel disease patients”. Co-Director: Dr. Rodrigo Quera. Thesis completed 2007.

11) Sergio Arancibia Z: Biochemistry, Faculty of Chemistry and Pharmacy, Universidad de Chile. Thesis title: “Regulation of TLR2 signaling pathway by PI3K upon bacterial infection”. Thesis completed 2006.

12) Pablo Olivero R: Biochemistry, Faculty of Chemistry and Pharmacy, Universidad de Chile. Thesis title: “Participation of PKC in hypotonicity induced by taurine“.Thesis completed 2002.

Best Work Presentation

SOCIEDAD CHILENA DE GASTROENTEROLOGIA

Chile, 2011

Genética de ST2 como factor predictivo de evolución desfavorable en pacientes con enfermedad inflamatoria intestinal. XXXVIII Congress of the Chilean Gastroenterology Society, Viña del Mar, Chile. Plenary talk, best work presentation award.
Paper of the Year

NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

Estados Unidos, 2004

Paper destacado del instituto en el año, premio paper of the year


Aberrant MUC1 accumulation in salivary glands of Sjögren's syndrome patients is reversed by TUDCA in vitro. Castro I, Albornoz N, Aguilera S, Barrera MJ, González S, Núñez M, Carvajal P, Jara D, Lagos C, Molina C, Urzúa U, Hermoso MA, González MJ. Article ISI SCOPUS Rheumatology (Oxford, England) (2020)
Glucocorticoids mobilize macrophages by transcriptionally up-regulating the exopeptidase DPP4 Diaz-Jimenez, David; Petrillo, Maria Grazia; Busada, Jonathan T.; Hermoso, Marcela A.; Cidlowski, John A. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Aberrant MUC1 accumulation in salivary glands of Sjögren’s syndrome patients is reversed by TUDCA in vitro Castro, Isabel; Albornoz, Nicolás; Aguilera, Sergio; Barrera, María-José; González, Sergio; Núñez, Matilde; Carvajal, Patricia; Jara, Daniela; Lagos, Carolina; Molina, Claudio; Urzúa, Ulises; Hermoso, Marcela A; González, María-Julieta Article Rheumatology (2019)
Editorial: Intestinal Homeostasis and Disease: A Complex Partnership Between Immune Cells, Non-Immune Cells, and the Microbiome De la Fuente, Marjorie; MacDonald, Thomas Thornton; Hermoso, Marcela A. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis Dubois-Camacho, Karen; Diaz-Jimenez, David; De la Fuente, Marjorie; Quera, Rodrigo; Simian, Daniela; Martinez, Maripaz; Landskron, Glauben; Olivares-Morales, Mauricio; Cidlowski, John A.; Xu, Xiaojiang; Gao, Guangping; Xie, Jun; Chnaiderman, Jonas; Soto-R Article ISI/SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
Interleukin 33/ST2 Axis Components Are Associated to Desmoplasia, a Metastasis-Related Factor in Colorectal Cancer Landskron, Glauben; De la Fuente Lopez, Marjorie; Dubois-Camacho, Karen; Diaz-Jimenez, David; Orellana-Serradell, Octavio; Romero, Diego; Sepulveda, Santiago A.; Salazar, Christian; Parada-Venegas, Daniela; Quera, Rodrigo; Simian, Daniela; Gonzalez, Maria Article ISI/SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren's syndrome patients Cortes, J; Hidalgo, J; Aguilera, S; Castro, I; Brito, M; Urra, H; Perez, P; Barrera, MJ; Carvajal, P; Urzua, U; Gonzalez, S; Molina, C; Bahamondes, V; Hermoso, M; Gonzalez, MJ Article ISI/SCOPUS JOURNAL OF AUTOIMMUNITY (2019)
Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients Lagos, Carolina; Carvajal, Patricia; Castro, Isabel; Jara, Daniela; González, Sergio; Aguilera, Sergio; Barrera, María-José; Quest, Andrew F.G.; Bahamondes, Verónica; Molina, Claudio; Urzúa, Ulises; Hermoso, Marcela A.; Leyton, Cecilia; González, María-Julieta Article ISI SCOPUS Clinical Immunology (2018)
Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjogrens syndrome Barrera, Maria-Jose; Aguilera, Sergio; Castro, Isabel; Gonzalez, Sergio; Carvajal, Patricia; Molina, Claudio; Hermoso, Marcela A.; Gonzalez, Maria-Julieta Article ISI SCOPUS AUTOIMMUNITY REVIEWS (2018)
Glucocorticoids Impair Phagocytosis and Inflammatory Response Against Crohns Disease-Associated Adherent-Invasive Escherichia coli Javier Olivares-Morales, Mauricio; Katherine De la Fuente, Marjorie; Dubois-Camacho, Karen; Parada, Daniela; Diaz-Jimenez, David; Torres-Riquelme, Alejandro; Xu, Xiaojiang; Chamorro-Veloso, Nayaret; Naves, Rodrigo; Gonzalez, Maria-Julieta; Quera, Rodrigo; Article ISI/SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
Impaired IRE1 alpha/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjogrens syndrome patients Sepúlveda, Denisse; Barrera, María-José; Castro, Isabel; Aguilera, Sergio; Carvajal, Patricia; Lagos, Carolina; González, Sergio; Albornoz, Nicolás; Bahamondes, Verónica; Quest, Andrew F G; Urzúa, Ulises; Molina, Claudio; Leyton, Cecilia; Hermoso, Marcela A; González, María-Julieta Article ISI SCOPUS RHEUMATOLOGY (2018)
A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis Díaz-Jiménez, David; Núñez, Lucía; De la Fuente, Marjorie; Dubois-Camacho, Karen; Sepúlveda, Hugo; Montecino, Martín; Torres-Riquelme, Alejandro; García-González, Paulina; Chnaiderman, Jonás; Vossenkamper, Anna; MacDonald, Thomas T.; Simian, Daniela; Gonz Article ISI/SCOPUS Scientific Reports (2017)
Genetic Diversity and Virulence Determinants of Escherichia coli Strains Isolated from Patients with Crohn's Disease in Spain and Chile Quera, Rodrigo; De la Fuente, Marjorie; Hermoso, MA; Céspedes, S; Saitz, W; Del Canto, F; de la Fuente, M; Muñoz, M; Ginard, D; Khorrami, S; Giron, J; Rossello-Mora, R; Vidal, R Article ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2017)
Presence of intracellular Escherichia coli in patients with inflammatory bowel disease de la Fuente, M; Chahuan, I; Gutierrez, R; Diaz-Jimenez, D; Olivares, M; Vidal, R; Simian, D; Figueroa, C; Quera, R; Hermoso, MA Article ISI REVISTA MEDICA DE CHILE (2017)
Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1? synthesis, secretion, and degradation Boza P.; Ayala, P; Vivar, R; Humeres, C.; Cáceres F.T.; Munoz, C; Garcia, L.; Hermoso M.A.; Díaz-Araya G. Article ISI SCOPUS Molecular Immunology (2016)
Pro-inflammatory cytokines enhance ERAD and ATF6 pathway activity in salivary glands of Sjögren's syndrome patients Barrera, María-José; Aguilera, Sergio; Castro, Isabel; Cortés, Juan; Bahamondes, Verónica; Quest, Andrew F.G.; Molina, Claudio; González, Sergio; Hermoso, Marcela; Urzúa, Ulises; Leyton, Cecilia; González, María-Julieta Article ISI/SCOPUS JOURNAL OF AUTOIMMUNITY (2016)
Soluble ST2 is a sensitive clinical marker of ulcerative colitis evolution Díaz-Jiménez, David; De la Fuente, Marjorie; Dubois-Camacho, Karen; Landskron, Glauben; Fuentes, Janitza; Pérez, Tamara; González, María Julieta; Simian, Daniela; Hermoso, Marcela A.; Quera, Rodrigo Article ISI/SCOPUS BMC GASTROENTEROLOGY (2016)
Crohn associated microbial communities associated to colonic mucosal biopsies in patients of the western Mediterranean Vidal, R; Ginard, D; Khorrami, S; Mora-Ruiz, M; Munoz, R.; Hermoso, M; Diaz S.; Cifuentes, A.; Orfila, A.; Rossello-Mora, R Article ISI SCOPUS Systematic and Applied Microbiology (2015)
MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjogren's syndrome Sung HH; Castro, I; Gonzalez S.; Aguilera, S; Smorodinsky NI; Quest, AFG; Bahamondes, V; Alliende C.; Cortes, J; Molina C.; Urzua, U; Barrera, MJ; Hermoso, M; Herrera L.; Leyton, C; Gonzalez, MJ Article ISI SCOPUS Oral Diseases (2015)
Perinatal Asphyxia Leads to PARP-1 Overactivity, p65 Translocation, IL-1 beta and TNF-alpha Overexpression, and Apoptotic-Like Cell Death in Mesencephalon of Neonatal Rats: Prevention by Systemic Neonatal Nicotinamide Administration Neira-Pena, T; Rojas-Mancilla, E; Munoz-Vio, V; Perez, R; Gutierrez-Hernandez, M; Bustamante D.; Morales P.; Hermoso, MA; Gebicke-Haerter, P; Herrera-Marschitz, M Article ISI SCOPUS Neurotoxicity Research (2015)
RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity. Valiente-Echeverría F, Hermoso MA, Soto-Rifo R. Article Rev Med Virol (2015)
Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjogren's syndrome? Barrera, MJ; Aguilera, S; Veerman, E; Quest, AFG; Diaz-Jimenez, D; Urzua, U; Cortes, J; Gonzalez S.; Castro, I; Molina C.; Bahamondes, V; Leyton, C; Hermoso, MA; Gonzalez, MJ Article ISI SCOPUS Rheumatology (United Kingdom) (2015)
Chronic inflammation and cytokines in the tumor microenvironment. Landskron, Glauben; De la Fuente, Marjorie; Thuwajit, Peti; Thuwajit, Chanitra; Hermoso, Marcela A Article Journal of immunology research (2014)
Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome De La Fuente M.; Franchi, L; Araya D.; Diaz-Jimenez, D; Olivares M.; Alvarez-Lobos, M; Golenbock, D; Gonzalez, MJ; Lopez-Kostner, F; Quera, R; Nuñez G.; Vidal, R; Hermoso, MA Article ISI SCOPUS INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2014)
Metalloproteinase-Dependent TLR2 Ectodomain Shedding is Involved in Soluble Toll-Like Receptor 2 (sTLR2) Production Langjahr P.; Diaz-Jimenez, D; De La Fuente M.; Rubio E.; Golenbock, D; Bronfman F.C.; Quera, R; Lez M.-J.G.; Hermoso M.A.; Benjamim C.F. Article ISI SCOPUS PLOS ONE (2014)
Innate immunity modulation by the IL-33/ST2 system in intestinal mucosa. García-Miguel, Marina; González, M Julieta; Quera, Rodrigo; Hermoso, Marcela A Article BioMed research international (2013)
SjÃ¶gren's syndrome and the epithelial target: a comprehensive review. Barrera, M J; Bahamondes, V; Sepúlveda, D; Quest, A F G; Castro, I; Cortés, J; Aguilera, S; Urzúa, U; Molina, C; Pérez, P; Ewert, P; Alliende, C; Hermoso, M A; González, S; Leyton, C; González, M J Article Journal of autoimmunity (2013)
Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjogren's syndrome patients is linked to ectopic mucin secretion Barrera M.J.; Sánchez, M; Aguilera, S; Alliende C.; Bahamondes, V; Molina C.; Quest, A.F.G.; Urzua, U; Castro, I; Gonzalez S.; Sung H.H.; Albornoz, A; Hermoso, M; Leyton, C; Gonzalez M.-J. Article ISI SCOPUS Journal of Autoimmunity (2012)
Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren's syndrome patients Castro, I; Aguilera, S; Brockhausen, I; Alliende C.; Quest, A.F.G.; Molina C.; Urzua, U; Mandel, U; Bahamondes, V; Barrera M.J.; Sánchez, M; Gonzalez S.; Hermoso, M; Leyton, C; Gonzalez M.-J. Article ISI SCOPUS Rheumatology (United Kingdom) (2012)
Effect of the electrostatic potential on the internalization mechanism of cell penetrating peptides derived from TIRAP Flores K.A.; Salgado J.C.; Zapata-Torres, G; Gerdtzen, Z.P.; Gonzalez M.-J.; Hermoso M.A. Article ISI SCOPUS Biotechnology and Bioprocess Engineering (2012)
Increased production of soluble TLR2 by lamina propria mononuclear cells from ulcerative colitis patients Candia, E.; Diaz-Jimenez, D; Langjahr P.; Nunez L.E.; De La Fuente M.; Farfan, N; Lopez-Kostner, F; Abedrapo M.; Alvarez-Lobos, M; Pinedo, G; Beltrán C.J.; González C; Gonzalez M.-J.; Quera, R; Hermoso M.A. Article ISI SCOPUS IMMUNOBIOLOGY (2012)
Mechanotransduction and epigenetic control in autoimmune diseases (vol 10, pg 175, 2011) Gonzalez S.; Aguilera, S; Urzua, U; Quest, AFG; Molina C.; Alliende C.; Hermoso, M; Gonzalez, MJ Article AUTOIMMUNITY REVIEWS (2012)
Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes in vaccinated melanoma patients Tittarelli, A; González F.E.; Pereda, C; Mora, G; Munoz L.; Saffie C; Garcia, T.; Diaz, D.; Falcon, C; Hermoso, M; López, M N.; SALAZAR ONFRAY F Article ISI SCOPUS Cancer Immunology, Immunotherapy (2012)
"Corrigendum to ""Mechanotransduction and epigenetic control in autoimmune diseases"" [J. Autoimmun. Rev. 10 (2011) 175-179]" Gonzalez S.; Urzua, U; Quest, A.F.G.; Alliende C.; Hermoso, M; Gonzalez M.-J.; Aguilera, S; Molina C. Article AUTOIMMUNITY REVIEWS (2011)
[Possible association between Mycobacterium avium subsp paratuberculosis infection and Crohn's disease]. Retamal, Patricio; Beltrán, Caroll; Abalos, Pedro; Quera, Rodrigo; Hermoso, Marcela Article Revista meÌ�dica de Chile (2011)
Alterations in Type I Hemidesmosome Components Suggestive of Epigenetic Control in the Salivary Glands of Patients With Sjogren's Syndrome Gonzalez S.; Aguilera, S; Alliende C.; Urzua, U; Quest, AFG; Herrera L.; Molina C.; Hermoso, M; Ewert, P; Brito M.; Romo, R; Leyton, C; Perez, P.; Gonzalez, MJ Article ISI SCOPUS Arthritis and Rheumatism (2011)
Changes in Rab3D Expression and Distribution in the Acini of Sjogren's Syndrome Patients Are Associated With Loss of Cell Polarity and Secretory Dysfunction Bahamondes, V; Albornoz, A; Aguilera, S; Alliende C.; Molina C.; Castro, I; Urzua, U; Quest, AFG; Barrera, MJ; Gonzalez S.; Sánchez, M; Hartel, S; Hermoso, M; Leyton, C; Gonzalez, MJ Article ISI SCOPUS Arthritis and Rheumatism (2011)
Heat-Shock Induction of Tumor-Derived Danger Signals Mediates Rapid Monocyte Differentiation into Clinically Effective Dendritic Cells Aguilera R.; Saffie C; Tittarelli, A; Gonzalez, FE; Ramirez M.; Reyes, D; Pereda, C; Hevia D; Garcia, T.; Salazar, L; Ferreira A.; Hermoso, M; Mendoza-Naranjo, A; Ferrada C.; GARRIDO, P.; López MN; SALAZAR ONFRAY F Article ISI SCOPUS Clinical Cancer Research (2011)
Mechanotransduction and epigenetic control in autoimmune diseases. González S, Aguilera S, Urzúa U, Quest AF, Molina C, Alliende C, Hermoso M, González MJ. Article Autoimmun Rev. (2011)
Phosphatidylinositol 3-kinase interacts with the glucocorticoid receptor upon TLR2 activation Arancibia S.; Benitez D.; Nunez L.E.; Langjahr P.; Candia, E.; Hermoso M.A.; Jewell C.M.; Cidlowski, J.A.; Zapata-Torres, G; Gonzalez M.-J. Article ISI SCOPUS Journal of Cellular and Molecular Medicine (2011)
Soluble ST2: A new and promising activity marker in ulcerative colitis Diaz-Jimenez, D; nunez, le; Beltran, CJ; Candia, E.; Suazo, C; Alvarez-Lobos, M; Gonzalez, MJ; Hermoso, MA; Quera, R Article ISI SCOPUS World Journal of Gastroenterology (2011)
Characterization of the Novel ST2/IL-33 System in Patients with Inflammatory Bowel Disease Beltran, CJ; nunez, le; Diaz-Jimenez, D; Farfan, N; Candia, E.; Heine C.; López F; Gonzalez, MJ; Quera, R; Hermoso, MA Article ISI SCOPUS Inflammatory Bowel Diseases (2010)
Constant TCR triggering suggests that the TCR expressed on intestinal intraepithelial gamma delta T cells is functional in vivo Malinarich, FH; Grabski, E; Worbs, T; Chennupati, V; Haas, JD; Schmitz, S; Candia, E.; Quera, R; Malissen, B; Forster, R; Hermoso, M; Prinz, I Article ISI SCOPUS European Journal of Immunology (2010)
Disruption of Tight Junction Structure in Salivary Glands From Sjogren's Syndrome Patients Is Linked to Proinflammatory Cytokine Exposure Ewert, P; Aguilera, S; Alliende C.; Kwon, YJ; Albornoz, A; Molina C.; Urzua, U; Quest, AFG; Olea, N.; Perez, P.; Castro, I; Barrera, MJ; Romo, R; Hermoso, M; Leyton, C; Gonzalez, MJ Article ISI SCOPUS Arthritis and Rheumatism (2010)
An update on the pathogenesis of celiac disease Enfermedad celíaca y su patogenia Herrera, M.J.; Hermoso M.A.; Quera, R Article REVISTA MEDICA DE CHILE (2009)
Gene expression and chromosomal location for susceptibility to Sjogren's syndrome Perez, P.; Anaya, JM; Aguilera, S; Urzua, U; Munroe D.; Molina C.; Hermoso, MA; Cherry, JM; Alliende C.; Olea, N.; Ruiz-Narvaez, E; Gonzalez, MJ Article ISI SCOPUS JOURNAL OF AUTOIMMUNITY (2009)
GENE EXPRESSION AND CHROMOSOMAL LOCATION FOR SUSCEPTIBILITY TO SJOGRENS SYNDROME Perez, Paola; Anaya Juan; Aguilera, Sergio; Urzúa, Ulises; Munroe, David; Molina, Claudio; Hermoso, Marcela Article JOURNAL OF AUTOIMMUNITY (2009)
Peripheral cytokine profile in Chilean patients with Crohn's disease and ulcerative colitis Beltrán C.J.; Candia, E.; Erranz B.; Hermoso M.A.; Figueroa C.; Quera, R; Gonzalez M.-J. Article SCOPUS European Cytokine Network (2009)
PERIPHERAL CYTOKINE PROFILE IN CHILEAN PATIENTS WITH CROHNS DISEASE AND ULCERATIVE COLITIS Beltran, Caroll; Erranz, Benjamín; Candia, Enzo; Figueroa, Carolina; Gonzalez, Maria; Quera, Rodrigo; Hermoso, Marcela Article European Cytokine Network (2009)
Regulation of Cell Survival by Resveratrol Involves Inhibition of NF kappa B-Regulated Gene Expression in Prostate Cancer Cells Benitez, DA; Hermoso, MA; Pozo-Guisado, E; Fernandez-Salguero, PM; Castellon EA. Article ISI SCOPUS PROSTATE (2009)
Severe alterations in expression and localisation of alpha 6 beta 4 integrin in salivary gland acini from patients with Sjogren syndrome Velozo J.; Aguilera, S; Alliende C.; Ewert, P; Molina C.; Perez, P.; Leyton, L; Quest, A; Brito M.; Gonzalez S.; Leyton, C; Hermoso, M; Romo, R; Gonzalez, MJ Article ISI SCOPUS ANNALS OF THE RHEUMATIC DISEASES (2009)
A ROLE FOR ST2 IN MAST CELL DEGRANULATION: A CONTRIBUTORY FACTOR IN IBD Beltran, Caroll; Quera, Rodrigo; Hermoso, Marcela; Oneill, L. Article gastroenterología latinoamericana (2008)
DETERMINACION DE LA QUIMIOQUINA CCL4 MURINA EN CELULAS T TOTALES Y GAMA DELTA INTRAEPITELIALES INTESTINALES Malinarich, Frano; Diaz, David; Quera, Rodrigo; Hermoso, Marcela Article gastroenterología latinoamericana (2008)
IL-23R Arg381Gln polymorphism in Chilean patients with inflammatory bowel disease Venegas, M; Beltran, CJ; Alvarez L.; Castro A.; Torres T.; Leal, AD; Lahsen, FM; Hermoso, MA; Quera, R Article ISI SCOPUS European Cytokine Network (2008)
Effect of oestradiol and progesterone on the instant and directional velocity of microsphere movements in the rat oviduct: gap junctions mediate the kinetic effect of oestradiol Rios M.; Hermoso, M; Sanchez, TM; Croxatto HB; Villalón MJ Article ISI SCOPUS REPRODUCTION FERTILITY AND DEVELOPMENT (2007)
17-beta-Estradiol upregulates COX-2 in the rat oviduct Martinez, SP; Hermoso, M; Farina M.; Ribeiro, ML; Rapanelli, M; Espinosa,M; Villalón M.; Franchi, A Article ISI SCOPUS PROSTAGLANDINS & OTHER LIPID MEDIATORS (2006)
Inhibition of nuclear factor-kappa B enhances the capacity of immature dendritic cells to induce antigen-specific tolerance in experimental autoimmune encephalomyelitis Iruretagoyena, MI; Sepulveda, SE; Lezana, JP; Hermoso, M; Bronfman, M; Gutierrez MA; Jacobelli, SH; Kalergis, AM Article ISI SCOPUS JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
NOD2/CARD15 and Toll-like 4 receptor gene polymorphism in Chilean patients with inflammatory bowel disease Figueroa C.; Peralta, A; Herrera L.; Castro P. ; Gutierrez A.; Valenzuela J.; Aguillón JC; Quera, R; Hermosa, MA Article ISI SCOPUS European Cytokine Network (2006)
Cell volume regulation in response to hypotonicity is impaired in HeLa cells expressing a protein kinase C alpha mutant lacking kinase activity Hermoso, M; Olivero P.; Torres R.; Riveros A.; Quest, AFG; Stutzin A. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
ClC-3 is a fundamental molecular component of volume-sensitive outwardly rectifying Cl- channels and volume regulation in HeLa cells and Xenopus laevis oocytes Hermoso, M; Satterwhite, CM; Andrade, YN; Hidalgo J.; Wilson, SM; Horowitz B.; Hume, JR Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Functional inhibition of native volume-sensitive outwardly rectifying anion channels in muscle cells and Xenopus oocytes by anti-CIC-3 antibody Duan, D; Zhong, J; Hermoso, M; Satterwhite C.M.; Rossow C.F.; Hatton W.J.; Yamboliev I.; Horowitz B.; Hume J.R. Article SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2001)
Platelet activating factor increases ciliary activity in the hamster oviduct through epithelial production of prostaglandin E-2 Hermoso, M; Barrera, N; Morales, B; Pérez S.; Villalón M. Article ISI PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2001)
Identification of gap junctions in the oviduct and regulation of connexins during development and by sexual hormones Hermoso, M; Sáez, J.C.; Villalón M. Article EUROPEAN JOURNAL OF CELL BIOLOGY (1997)


ARE SALIVARY MUCINS ABLE TO TRIGGER A PROINFLAMMATORY RESPONSE? Barrera, MJ; Aguilera, S; Hermoso, M; Langjahr P.; Cortes, J; Castro, I; Molina C.; Gonzalez S.; Alliende C.; Bahamondes, V; Sepulveda D.; Leyton, C; Gonzalez, MJ Abstract ISI ANNALS OF THE RHEUMATIC DISEASES (2013)
Identification of Intracellular Escherichia Coli (IEC), Associated With Crohn's Disease, in Other Intestinal Pathologies Quera, R; De La Fuente M.; Sabotier, M; Diaz-Jimenez, D; Simian, D; Perez T.; Segovia R.; Hermoso, M Abstract ISI INFLAMMATORY BOWEL DISEASES (2012)
Rapid protocol to generate tolerogenic dendritic cells using microbial lipopeptide (BLP). Aravena, OA; Salazar, L; Mass, C; Aguirre A.; Catalan, D; Hermoso, M; Aguillón JC Abstract CLINICAL IMMUNOLOGY (2005)
Inhibition of native volume-senstive chloride currents and RVD in HeLa cells and Xenopus laevis oocytes by ClC-3 antisense Satterwhite, CM; Hermoso, M; Wilson S.; Horowitz B.; Hume, JR Abstract BIOPHYSICAL JOURNAL (2002)
Functional inhibition of native and recombinant volume-sensitive outwardly rectifying anion channels by CLC-3 antibody Satterwhite, CM; Duan, D; Zhong, J; Hermoso, M; Rossow, CF; Hatton, WJ; Horowitz B.; Hume, JR Abstract ISI FASEB JOURNAL (2001)
Functional knockout of native and recombinant volume-sensitive outwardly rectifying anion channels (VSOACs) by Anti-ClC3 antibody Hume, JR; Duan, D; Zhong, J; Hermoso, M; Satterwhite, CM; Rossow, CF; Hatton, MJ; Horowitz B. Abstract BIOPHYSICAL JOURNAL (2001)
Regulation of smooth muscle activity in the oviduct by sex hormones Villalón MJ; Martínez, S.; Hermoso, M; Sáez JC Abstract JOURNAL OF PHYSIOLOGY-LONDON (2000)


Current knowledge in inflammatorty bowel diseases immunopathogenesis Salgado, N; Díaz-Jiménez D.; De La Fuente M.; Quera, R; Hermoso M.A. BookWhole SCOPUS Materials Science and Technology Conference and Exhibition 2014, MS and T 2014 (2013)
Nutrition and inflammatory bowel disease Bascuñán K.; Díaz-Jiménez D.; Quera, R; Hermoso M.A. BookWhole SCOPUS Materials Science and Technology Conference and Exhibition 2014, MS and T 2014 (2013)


Effect of the electrostatic potential on the internalization mechanism of cell penetrating peptides Flores K.A.; Salgado J.C.; Zapata-Torres, G; Gerdtzen, Z.P.; Gonzalez M.-J.; Hermoso M.A. ConferencePaper 1604-2004: SUPERNOVAE AS COSMOLOGICAL LIGHTHOUSES (2011)


Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome (vol 304, pg 384, 2014) De La Fuente M.; Franchi, L; Araya D.; Diaz-Jimenez, D; Olivares M.; Alvarez-Lobos, M; Golenbock, D; Gonzalez, MJ; Lopez-Kostner, F; Quera, R; Nuñez G.; Vidal, R; Hermoso, MA Errata ISI SCOPUS International Journal of Medical Microbiology (2015)
Peripheral cytokine profile in Chilean patients with Crohn's disease and ulcerative colitis (vol 1, pg 33, 2008) Beltran, CJ; Candia, E.; Erranz B.; Figueroa C.; Gonzalez, MJ; Quera, R; Hermoso, MA Errata ISI SCOPUS European Cytokine Network (2009)


Development, production and characterization of a recombinant human antibody against the soluble variant of ST2 (sST2) with therapeutic potential for the treatment of ulcerative colitis Hermoso M.A.; MOLINA, MARÍA C; Gonzalez, Maria-Julieta Proyecto (2018)
Gastrointestinal diseases: loss of gut homeostasis due to the complex interaction between genetics, immune response and microbiota Hermoso M.A. Proyecto (2018)
Role of corticoids signaling on intestinal steroidogenesis in ulcerative colitis FONDECYT (1170648) Proyecto 2017-2020 Inv. Principal
IL-33 inflammatory cycle=> Role in Colangiocarcinoma metastasis and potential application as a therapeutic target. Cancer Foundation of Thailand. (CFT2560) Proyecto 2015-2018 Coinvestigador(a)
Microarray analysis of AIEC infected THP-1 cells=> effect of glucocorticoids National Institutes of Environmental Health Sciences, National Institutes of Health (NIEHS/NIH). (NIEHS 2014-002) Proyecto 2014-2015 Coinvestigador(a)
Caracterización del MicroRNA 378a-3p en Pacientes con Colitis Ulcerosa y su Potencial Asociación con la Terapia Esteroidal. Dirección Académica CLC (DA 2013) Proyecto 2013-2015 Coinvestigador(a)
Interacción patógeno-hospedero=> la necesidad de generar conocimiento de cómo patógeno promueve enfermedades inflamatorias y el cáncer PCI (130037) Proyecto 2013-2014 Inv. Responsable
The atlas of the HIV-1 genomic messenger ribonucleoprotein (mrnp) complex. PCI (USA-2013-0) Proyecto 2013-2015 Coinvestigador(a)
CELLULAR AND MOLECULAR MECHANISMS RELEVANT IN THE INTERACTION OF CLINICAL ISOLATES OF ADHERENT INVASIVE ESCHERICHIA COLI (AIEC) WITH EPITHELIAL CELLS OR MACROPHAGES IN CROHN S DISEASE FONDECYT (1120577) Proyecto 2012-2016 Inv. Responsable
Single nucleotide polymorphisms (SNPs), located in the promoter region of ST2 gene, correlate with sST2 circulating levels and influence IBD severity. Dirección Académica CLC (DA 2012) Proyecto 2012-2013 Coinvestigador(a)
Identificación y caracterización de la cepa intestinal E. coli invasiva derivada de pacientes con enfermedad de Crohn. Dirección Académica CLC (DA2011) Proyecto 2011-2013 Coinvestigador(a)
ROLE OF ST2/IL-33 SYSTEM IN MUCOSAL INFLAMMATION AND INFLAMMATORY BOWEL DISEASES PATHOGENIA FONDECYT (1110381) Proyecto 2011-2015 Coinvestigador(a)
Regulation of inflammatory responses of monocyte/macrophages induced by an agonist of TLR2 in human intestine. Dirección Académica CLC (DA2010) Proyecto 2010-2011 Coinvestigador(a)
CARACTERIZACION DE MECANISMOS POSIBLES DE PROCESAMIENTO DE TLR2 Y SU PAPEL INMUNOREGULADOR EN LA ENFERMEDAD INFLAMATORIA INTESTINAL FONDECYT (1080290) Proyecto 2008-2012 Inv. Responsable
MODULACION DE LA SENSIBILIDAD A GLUCOCORTICOIDES EN INFECCIONES AGUDAS. ROL DE RECEPTORES TIPO TOLL. FONDECYT (1080529) Proyecto 2008-2011 Coinvestigador(a)
CARACTERIZACION DE LA FUNCION INMUNO REGULADORA DE ST2 EN LAS ENFERMEDADES INFLAMATORIAS INTESTINALES. FONDECYT (1070954) Proyecto 2007-2010 Coinvestigador(a)


Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases Venegas, DP; De la Fuente, MK; Landskron, G; Gonzalez, MJ; Quera, R; Dijkstra, G; Harmsen, HJM; Faber, KN; Hermoso, MA Review ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology Dubois-Camacho K.; Ottum P.A.; Franco-Muñoz D.; De La Fuente M.; Torres-Riquelme A.; Díaz-Jiménez D.; Olivares-Morales M.; Astudillo G.; Quera R.; Hermoso M.A. Review ISI SCOPUS WORLD JOURNAL OF GASTROENTEROLOGY (2017)
RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity Valiente-Echeverria, F; Hermoso, MA; Soto-Rifo, R Review ISI SCOPUS Reviews in Medical Virology (2015)
The IL-33/ST2 axis: Role in health and disease De La Fuente M.; MacDonald, TT; Hermoso, MA Review ISI SCOPUS Cytokine and Growth Factor Reviews (2015)
Chronic Inflammation and Cytokines in the Tumor Microenvironment Landskron G.; De La Fuente M.; Thuwajit, P; Thuwajit, C; Hermoso, MA Review ISI SCOPUS JOURNAL OF IMMUNOLOGY RESEARCH (2014)
Innate Immunity Modulation by the IL-33/ST2 System in Intestinal Mucosa Garcia-Miguel, M; Gonzalez, MJ; Quera, R; Hermoso, MA Review ISI SCOPUS BioMed Research International (2013)
Oral dryness in Sjogren's syndrome patients. Not just a question of water Castro, I; Sepulveda D.; Cortes, J; Quest, AFG; Barrera, MJ; Bahamondes, V; Aguilera, S; Urzua, U; Alliende C.; Molina C.; Gonzalez S.; Hermoso, MA; Leyton, C; Gonzalez, MJ Review ISI SCOPUS Autoimmunity Reviews (2013)
Sjogren's syndrome and the epithelial target: A comprehensive review Barrera, MJ; Bahamondes, V; Sepulveda D.; Quest, AFG; Castro, I; Cortes, J; Aguilera, S; Urzua, U; Molina C.; Perez, P.; Ewert, P; Alliende C.; Hermoso, MA; Gonzalez S.; Leyton, C; Gonzalez, MJ Review ISI SCOPUS Journal of Autoimmunity (2013)
Mechanotransduction and epigenetic control in autoimmune diseases Gonzalez S.; Aguilera, S; Urzua, U; Quest, AFG; Molina C.; Alliende C.; Hermoso, M; Gonzalez, MJ Review ISI SCOPUS Autoimmunity Reviews (2011)
Possible association between Mycobacterium avium subsp paratuberculosis infection and Crohn's disease Retamal P.; beltran, C; Abalos P.; Quera, R; Hermoso, M Review REVISTA MEDICA DE CHILE (2011)
An update on the pathogenesis of celiac disease Herrera, MJ; Hermoso, MA; Quera, R Review ISI REVISTA MEDICA DE CHILE (2009)
Enfermedad celíaca y su patogenia Herrera, Maria José; Hermoso, Marcela A; Quera, Rodrigo Review SCIELO REVISTA MEDICA DE CHILE (2009)
Enfermedad inflamatoria intestinal: Una mirada inmunológica Sepúlveda, Sofía E; Beltrán, Caroll J; Peralta, Alexis; Rivas, Paola; Rojas, Nestor; Figueroa, Carolina; Quera, Rodrigo; Hermoso, Marcela A Review SCIELO REVISTA MEDICA DE CHILE (2008)
Inflammatory bowel diseases: An immunological approach Sepulveda, SE; Beltran, CJ; Peralta, A; Rivas, P; Rojas, N; Figueroa C.; Quera, R; Hermoso, MA Review REVISTA MEDICA DE CHILE (2008)

Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

Rodrigo Quera

Gastroenterólogo

Gastroenterología

CLÍNICA LAS CONDES, SERVICIO DE GASTROENTEROLOGÍA

Santiago, Chile

Maria González

Academico

FACULTAD DE MEDICINA - UNIVERSIDAD DE CHILE

Santiago, Chile

Claudio Molina

Director Investigación

Investigación

Universidad San Sebastián

Santiago, Chile

ULISES URZUA

Assistant Professor

ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

Sergio Gonzalez

Profesor titular

Patología General y Oral

Universidad Mayor

Santiago, Chile

Isabel Castro

Profesor Asistente

Tecnología Médica

Universidad de Chile

Santiago, Chile

Marjorie De la Fuente

Académico investigador

Escuela de Medicina

Universidad Finis Terrae

Santiago , Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

David Diaz

Asistente de Investigación

Instituto de Ciencias Biomédicas, Facultad de Medicina

Universidad de Chile

Santiago, Chile

Sergio Aguilera

Reumatólogo

CLÍNICA INDISA

Santiago, Chile

Caroll Beltrán

Profesor Asistente, Investigador Principal

Medicina

Universidad de Chile, Fac Medicina

SANTIAGO, Chile

roberto vidal

Head of Pathogenic Escherichia coli Laboratory

Director Microbiology and Mycology Program

UNIVERSIDAD DE CHILE

Santiago, Chile

PATRICIA CARVAJAL

Lucia Nuñez

ENCARGADA DE VALORACION

FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

María Barrera

Profesor Asistente

Odontología

Universidad San Sebastián, Facultad de Odontología

Santiago, Chile

Manuel Alvarez

Gastroenterologist and Chief of Institute of Medicine

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

Amelina Albornoz

Post doctorado

Virología Molecular

Fundación Ciencia & Vida

Santiago, Chile

Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

Ziomara Gerdtzen

Profesora Asociada

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

Fermín González

Profesor Asociado

Odontología Conservadora

Universidad de Chile

Santiago, Chile

DENISSE SEPULVEDA

Postdoc

Universidad Mayor de Chile

Santiago, Chile

Luisa Herrera

Profesor Asociado

Incstituto de Ciencias Biomédicas, Programa de Genética Humana

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA-ICBM

Santiago, Chile

Glauben Landskron

Academic Researcher

Escuela de Medicina

Universidad Finis Terrae

Santiago, Chile

Nancy Farfán

Post-doc.

Farmacología

Universidad de Chile

Santiago, Chile

Andrés Tittarelli

Profesor Asociado

Instituto Universitario de Investigación y Desarrollo Tecnológico (IDT)

Universidad Tecnológica Metropolitana

Santiago, Chile

Edgardo Rojas

Académico e Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo OHiggins

Santiago, Chile

Cristian Falcón

Urólogo

Hospital San Juan de Dios

Santiago, Chile

Benjamín Erranz

Investigador-Docente

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

daniel hevia

Investigador PhD

Inmunologia

Universidad de Chile

santiago, Chile

Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

Daniela Simian

Enfermera de Investigación

Subdirección de Investigación

Clínica Las Condes

Santiago, Chile

Raúl Vivar

Profesor Asistente

Universidad de Chile

Santiago, Chile

Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Claudia Muñoz

Postdoctorado

Universidad de Chile

Santiago, Chile

Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

JUAN AGUILLON

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

Mariana Rios

Investigador

Facultad de Ciencias Biológicas

pontificia Universidad Católica de Chile

Santiago, Chile

ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

José Salgado

Associate Professor

Chemical Engineering, Biotechnology and Materials

UNIVERSIDAD DE CHILE

Santiago, Chile

Nelson Barrera

Associate Professor

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

Sergio Arancibia

Medical Science Liaison

Medical Affairs

Johnson & Johnson (Janssen Pharmaceutical)

Santiago, Chile

Lorena Salazar

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Lampa, Chile

Patricio Retamal

Profesor Asistente

Medicina Preventiva Animal

FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

Raquel Aguilera

PROFESOR ASISTENTE

INMUNOLOGÍA CLÍNICA Y REUMATOLOGÍA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Daniela Parada

Asistente de investigación

Programa Disciplinario de Inmunología

Universidad de Chile

Santiago, Chile

Ariel Castro

Académico

Psiquiatria y Salud Mental

Hospital Clinico Universidad de Chile

Santiago, Chile

Leonel Muñoz

Assistant Professor

Escuela de Medicina

Universidad de Valparaíso

Viña del Mar, Chile

Felipe Del Canto

Profesor Asistente

Programa de Microbiologia y Micologia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Ana Riveros

Profesor Asistente

Departamento de Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

Pablo Olivero

Profesor Adjunto

Patologia y Fisiologia

Universidad de Valparaiso

Viña del Mar, Chile

Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

Marcela Alejandra Hermoso Ramello

Líneas de Investigación

Educación

Biochemist, UNIVERSIDAD DE BUENOS AIRES. Argentina, 1987

Biological Sciences in Physiology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997

Experiencia Académica

Full Professor Full Time

ASSOCIATE PROFESSOR Full Time

Experiencia Profesional

Biochemist Full Time

PhD Student Full Time

Post-doc at Dr. Joseph Hume Laboratory Full Time

Post-doc at Dr. John A. Cidlowski Laboratory Full Time

Founder and Head Full Time

Assistant Professor Full Time

Associate Professor Full Time

Associate Professor Full Time

Associate Professor Full Time

Formación de Capital Humano

Premios y Distinciones

Best Work Presentation

Paper of the Year

Article (63)

Abstract (7)

BookWhole (2)

ConferencePaper (1)

Errata (2)

Proyecto (16)

Role of corticoids signaling on intestinal steroidogenesis in ulcerative colitis

IL-33 inflammatory cycle=> Role in Colangiocarcinoma metastasis and potential application as a therapeutic target.

Microarray analysis of AIEC infected THP-1 cells=> effect of glucocorticoids

Caracterización del MicroRNA 378a-3p en Pacientes con Colitis Ulcerosa y su Potencial Asociación con la Terapia Esteroidal.

Interacción patógeno-hospedero=> la necesidad de generar conocimiento de cómo patógeno promueve enfermedades inflamatorias y el cáncer

The atlas of the HIV-1 genomic messenger ribonucleoprotein (mrnp) complex.

CELLULAR AND MOLECULAR MECHANISMS RELEVANT IN THE INTERACTION OF CLINICAL ISOLATES OF ADHERENT INVASIVE ESCHERICHIA COLI (AIEC) WITH EPITHELIAL CELLS OR MACROPHAGES IN CROHN S DISEASE

Single nucleotide polymorphisms (SNPs), located in the promoter region of ST2 gene, correlate with sST2 circulating levels and influence IBD severity.

Identificación y caracterización de la cepa intestinal E. coli invasiva derivada de pacientes con enfermedad de Crohn.

ROLE OF ST2/IL-33 SYSTEM IN MUCOSAL INFLAMMATION AND INFLAMMATORY BOWEL DISEASES PATHOGENIA

Regulation of inflammatory responses of monocyte/macrophages induced by an agonist of TLR2 in human intestine.

CARACTERIZACION DE MECANISMOS POSIBLES DE PROCESAMIENTO DE TLR2 Y SU PAPEL INMUNOREGULADOR EN LA ENFERMEDAD INFLAMATORIA INTESTINAL

MODULACION DE LA SENSIBILIDAD A GLUCOCORTICOIDES EN INFECCIONES AGUDAS. ROL DE RECEPTORES TIPO TOLL.

CARACTERIZACION DE LA FUNCION INMUNO REGULADORA DE ST2 EN LAS ENFERMEDADES INFLAMATORIAS INTESTINALES.

Review (14)