Man

Rolando Marcelo Vernal Astudillo

Profesor Asociado

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


1. Análisis de la respuesta inmune inducida por microorganismos patógenos humanos. 2. Etiopatogenia de las enfermedades osteo-destructivas humanas. 3. Salud pública.

Educación

  •  Doctor en Ciencias Odontológicas, Universidad Complutense de Madrid. España, 2010
  •  Magíster en Ciencias Odotológicas, Universidad de Chile. Chile, 2004
  •  Cirujano Dentista, Universidad de Chile. Chile, 1994

Experiencia Académica

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Odontología

    Santiago, Chile

    Enero 2002 - A la fecha

Experiencia Profesional

  •   Profesor Asociado Part Time

    Universidad de Chile

    Santiago, Chile

    Enero 2002 - A la fecha

Formación de Capital Humano


1) Programa: Doctorado en Ciencias Veterinarias.
Institución: Facultad de Ecología y Recursos Naturales, Universidad Andrés Bello.
Participación: Tutor principal de Tesis.
Alumna: Myriam Pujol.

2) Programa: Magíster en Ciencias Odontológicas, mención Periodontología.
Institución: Facultad de Odontología, Universidad de Chile.
Participación: Tutor principal de Tesis.
Alumna: Leticia Rojas.

3) Programa: Magíster en Ciencias Odontológicas, mención Patología.
Institución: Facultad de Odontología, Universidad de Chile.
Participación: Tutor principal de Tesis.
Alumno: Mauricio Baeza.

4) Programa: Magíster en Ciencias Odontológicas, mención Periodontología.
Institución: Facultad de Odontología, Universidad de Chile.
Participación: Tutor principal de Tesis.
Alumno: Jaime Díaz.

5) Programa: Magíster en Ciencias Odontológicas, mención Periodontología.
Institución: Facultad de Odontología, Universidad de Chile.
Participación: Tutor principal de Tesis
Alumna: Samanta Melgar.

6) Programa: Magíster en Ciencias Odontológicas, mención Periodontología.
Institución: Facultad de Odontología, Universidad de Chile.
Participación: Tutor colaborador de Tesis.
Alumno: Arnoldo Hernández.

7) Programa: Magíster en Ciencias Odontológicas, mención Periodontología.
Institución: Facultad de Odontología, Universidad de Chile.
Participación: Tutor colaborador de Tesis.
Alumno: Nicolás Dutzan.

8) Programa: Especialidad en Periodoncia.
Institución: Facultad de Odontología, Universidad de Valparaíso.
Participación: Tutor principal de Tesis.
Alumno: Franz Strauss.


Premios y Distinciones

  •   Premio Colgate Senior

    International Association for Dental Research (IADR)

    Chile, 2011

    Mejor trabajo de investigación senior

  •   Premio Colgate Periodoncia

    International Association for Dental Research (IADR)

    Chile, 2013

    Mejor trabajo de investigación en Periodoncia


Tipos de Producción
 

Article (58)

Brucella canis induces canine CD4(+) T cells multi-cytokine Th1/Th17 production via dendritic cell activation
Capsular-defective Porphyromonas gingivalis mutant strains induce less alveolar bone resorption than W50 wild-type strain due to a decreased Th1/Th17 immune response and less osteoclast activity
IL-22-expressing CD4+ AhR+ T lymphocytes are associated with RANKL-mediated alveolar bone resorption during experimental periodontitis
Immunostimulatory activity of low-molecular-weight hyaluronan on dendritic cells stimulated with Aggregatibacter actinomycetemcomitans or Porphyromonas gingivalis
Multifunctional nanocarriers for the treatment of periodontitis: Immunomodulatory, antimicrobial, and regenerative strategies
Serotype b of Aggregatibacter actinomycetemcomitans triggers pro-inflammatory responses and amyloid beta secretion in hippocampal cells: a novel link between periodontitis and Alzheimer´s disease?
Alveolar bone resorption and Th1/Th17-associated immune response triggered during Aggregatibacter actinomycetemcomitans-induced experimental periodontitis are serotype-dependent
Does the Use of a "Walking Bleaching" Technique Increase Bone Resorption Markers?
Human periodontal ligament fibroblasts synthesize C-reactive protein and Th-related cytokines in response to interleukin (IL)-6 trans-signalling
Quality of life and stability of tooth color change at three months after dental bleaching
Regulatory T Lymphocytes in Periodontitis: A Translational View
Serotype a of Aggregatibacter actinomycetemcomitans down-regulates the increased serotype b-induced cytokine and chemokine production in dendritic cells
Th1/Th17/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report
The therapeutic potential of regulatory T lymphocytes in periodontitis: A systematic review
Bone resorptive activity in symptomatic and asymptomatic apical lesions of endodontic origin
Development of a self-report questionnaire designed population-based surveillance of gingivitis in adolescentes: Assessment of contente validity and reliability.
Differential human Th22-lymphocyte response triggered by Aggregatibacter actinomycetemcomitans serotypes
Effectiveness and Impact of the Walking Bleach Technique on Esthetic Self-perception and Psychosocial Factors: A Randomized Double-blind Clinical Trial
Increased levels of the Th22-associated cytokine (IL-22) and transcription fator (AhR) in periodontitis patients are associated with osteoclast resorptive activity and severity of the disease.
Oxidative Stress in the Local and Systemic Events of Apical Periodontitis
Variability in the response of canine and human dendritic cells stimulated with Brucella canis
ATP induces IL-1β secretion in Neisseria gonorrhoeae-infected human macrophages by a mechanism not related to the NLRP3/ASC/Caspase-1 axis.
Serotype b of Aggregatibacter actinomycetemcomitans increases osteoclast and memory T-lymphocyte activation
The Porphyromonas gingivalis O antigen is required for inhibition of apoptosis in gingival epithelial cells following bacterial infection.
C-Reactive Protein Expression Is Up-regulated in Apical Lesions of Endodontic Origin in Association with Interleukin-6
Differential expression of CC chemokines (CCLs) and receptors (CCRs) by human T lymphocytes in response to different Aggregatibacter actinomycetemcomitans serotypes
Genetic and phenotypic evidence of the Salmonella enterica serotype Enteritidis human-animal interface in Chile
H2O2 activates matrix metalloproteinases through the nuclear factor kappa B pathway and Ca2+ signals in human periodontal fibroblasts
Host response mechanisms in periodontal diseases
Neisseria gonorrhoeae Modulates Immunity by Polarizing Human Macrophages to a M2 Profile
T-lymphocyte phenotype and function triggered by Aggregatibacter actinomycetemcomitans is serotype-dependent
Variability of the Dendritic Cell Response Triggered by Different Serotypes of Aggregatibacter actinomycetemcomitans or Porphyromonas gingivalis Is Toll-Like Receptor 2 (TLR2) or TLR4 Dependent
Activation of RANKL-induced osteoclasts and memory T lymphocytes by Porphyromonas gingivalis is serotype dependant
Distinct human T-lymphocyte responses triggered by Porphyromonas gingivalis capsular serotypes
Serotype-dependent response of human dendritic cells stimulated with Aggregatibacter actinomycetemcomitans
Biochemical markers of bone metabolism in gingival crevicular fluid during early orthodontic tooth movement
High Levels of CXC Ligand 12/Stromal Cell-derived Factor 1 in Apical Lesions of Endodontic Origin Associated with Mast Cell Infiltration
Variabilidad de la síntesis de citoquinas por células dendríticas humanas estimuladas con los distintos serotipos de Aggregatibacter actinomycetecomitans
Interleukin-21 Expression and Its Association With Proinflammatory Cytokines in Untreated Chronic Periodontitis Patients
Levels of Interleukin-21 in Patients With Untreated Chronic Periodontitis
Differential cytokine expression by human dendritic cells in response to different Porphyromonas gingivalis capsular serotypes
Levels of Interferon-Gamma and Transcription Factor T-Bet in Progressive Periodontal Lesions in Patients With Chronic Periodontitis
Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells
Expression of proinflammatory cytokines in osteoarthritis of the temporomandibular joint
Translation controlled mRNAs: new drug targets in infectious diseases?
Variability in the response of human dendritic cells stimulated with Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans
CCL2 inhibits the apoptosis program induced by growth factor deprivation, rescuing functional T cells
Isolation of polysome-bound mRNA from solid tissues amenable for RT-PCR and profiling experiments
Stimulatory response of neutrophils from periodontitis patients with periodontal pathogens
High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4(+) T lymphocytes
Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity
RANKL in human periapical granuloma: possible involvement in periapical bone destruction
Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis
Levels of cytokine receptor activator of nuclear factor kappa B ligand in gingival crevicular fluid in untreated chronic periodontitis patients
Six-month Follow-up of the Effect of Nonvital Bleaching on IL-1β and RANK-L: A Randomized Clinical Trial

Book Section (1)

Review (1)

Host-Pathogen Interactions in Progressive Chronic Periodontitis

Nil Class (0)

78
Rolando Vernal

Profesor Asociado

Departamento de Odontología Conservadora

UNIVERSIDAD DE CHILE

Santiago, Chile

15
Jorge Gamonal

PROFESOR TITULAR

ODONTOLOGIA CONSERVADORA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

13
Emma Hernández

Académico 44 h, profesor titular

Oral Patology and Medicine

Universidad de Chile, Facultad de Odontología

SANTIAGO, Chile

4
Alejandra Chaparro

Profesora Titular

Odontología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

3
Loreto Abusleme

Assistant Professor

Oral pathology and medicine

FACULTAD DE ODONTOLOGÍA, UNIVERSIDAD DE CHILE

Santiago, Chile

3
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Juan Aguillón

PROFESSOR

IMMUNOLOGY PROGRAM

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

3
Paola Carvajal

Profesora Asistente

Odontologia Conservadora

FACULTAD DE ODONTOLOGÍA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Jaime Diaz

Cirujano dentista

Corporación de Desarrollo Social

Cesfam Dr. Alfonso Leng

Santiago, Chile

2
Patricia Pozo

Académico

Ciencias Farmacéuticas

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

2
Franco Cavalla

Assistant professor

Conservative dentistry

Universidad de Chile

Santiago, Chile

1
Mercedes Lopez

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

1
Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Andrea Paula

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

1
Roberto Vidal

Head of Pathogenic Escherichia coli Laboratory

Microbiology and Mycology Program

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Patricio Retamal

Profesor Asistente

Medicina Preventiva Animal

FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Timo Sorsa

Visiting Professor of Oral Biology

Institute of Dentistry

Karolinska Institutet

Stockholm, Suecia

1
José Pérez

Associate Professor

Biologia

Universidad Andres Bello

Santiago, Chile

1
Rodolfo Paredes

Ungraduated General Director

Academic Vice Rectory

UNIVERDAD ANDRÉS BELLO

Santiago, Chile

1
Claudia Lefimil

Profesor Asistente

Instituto de Investigación en Ciencias odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Octavio Aravena

INVESTIGADOR

INSTITUTO CIENCIAS BIOMÉDICAS

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Samanta Melgar-Rodriguez

Profesor Asistente

Odontología Conservadora

Universidad de Chile

Santiago, Chile

1
Marlén Barreto

Profesor asociado

UNIVERSIDAD AUTONOMA DE CHILE

Santiago de Chile, Chile