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YORLEY ANDREA DUARTE AYALA

profesor Asistente

Universidad Andrés Bello

Santiago, Chile

Síntesis Orgánica, Drug Discovery, Química Médica, Simulación Molecular.

Química de Alimentos, Universidad Pedagógica y Tecnológica de Colombia. Colombia, 2005
Magister en Ciencias Químicas, Universidad Nacional de Colombia. Chile, 2009
Doctora en Ciencias Aplicadas, UNIVERSIDAD DE TALCA. Chile, 2015

Auxiliar Docente. Especialización en Ciencia y Tecnología de Alimentos. Part Time

Universidad Nacional de Colombia

de Ciencias

Bogotá D.C., Colombia

2008 - 2009
Docente Tiempo Completo Ocasional; Química I y II, Química inorgánica y Orgánica. Full Time

Universidad del Atlántico

de Ciencias Químicas

Barranquilla, Colombia

2010 - 2010
Docente, laboratorios Química general-Organica Other

UNIVERSIDAD DE TALCA

Talca, Chile

2012 - 2013
Profesor Asistente Full Time

UNIVERSIDAD ANDRES BELLO

Ciencias de la Vida

Santiago, Chile

2020 - A la fecha
Investigadora Full Time

UNIVERSIDAD ANDRES BELLO

Ciencias de la Vida

Santiago, Chile

2015 - 2020

Analista Químico Full Time

Ivonne Bernier Laboratorio

Bogotá D. C. , Colombia

2006 - 2007
Estudiante Investigadora Full Time

Universidad de Talca

Talca, Chile

2011 - 2012

Tesis Co-dirigidas

“Si?ntesis y estudio de actividad biolo?gica de heterociclos nitrogenados ana?logos de quinolinas”.
Michelle Campos. 2014. Tecnologi?a Me?dica-Universidad de Talca.

“Si?ntesis de hibridos cumarino-quinolini?cos como inhibidoresselectivos de colinesterasas”.
Raphael Latorre. 2014. Tecnologi?a Me?dica-Universidad de Talca.

“Si?ntesis de hi?bridos cumarino-quinolinas como potenciales agentes antioxidantes”.
Oliver Orellana. 2015. Tecnologi?a Me?dica-Universidad de Talca.

CONGRESOS

II Encuentro Regional de Semilleros de Investigacio?n. Presentacio?n de la Ponencia del tema de trabajo de grado. UPTC, Duitama, Boyaca? Septiembre 22 al 24 de 2004.

VII Encuentro Nacional de Semilleros de Investigacio?n. Red Colombiana de Semilleros de Investigacio?n REDCOLSI y Universidad de San Buenaventura. Presentacio?n de la Ponencia de Trabajo de grado. Cartagena de Indias. Octubre 14-17 de 2004.

III Congreso latinoamericano de Estudiantes de Ciencia y Tecnologi?a de Alimentos, II Congreso Nacional ACECTA. Cartagena de Indias, Mayo 25 al 28 de 2005.

XXIX Congreso Latinoamericano de Qui?mica. Comportamiento del benzotriazol como grupo saliente en las reacciones de sustitucio?n nucleofi?lica de N,N-bis(1H- benzotriazoL-1-il-metil)-1,2-diaminobenceno con fenoles. Cartagena, Colombia 2010, 27.

XXIX Jornadas Chilenas de Qui?mica. SI?NTESIS DE DERIVADOS AZO?LICOS A PARTIR DE CETONAS ?,?---INSATURADAS Y BINUCLEOFILOS VIA REACCIO?N DE ADICIO?N 1,4 DE MICHAEL. Panima?vida, Chile 2011, QO 196.

XIX Jornadas Chilenas de Qui?mica. SINTESIS DE TETRAHIDROQUINOLINAS Y SU ACTIVIDAD BIOLOGICA. Panima?vida, Chile 2011, QO 198.

XVIII SINAQO. SINTESIS DE TETRAHIDROQUINOLINAS Y SU ACTIVIDAD BIOLOGICA. Villa Carlos Paz, Argentina 2011, QO 73.

XIX SINAQO. Synthesis of bistetrahydroquinolines as AchE inhibitor by double Diels- Alder reactions. Mar del Plata, Argentina 2013.

III SEQT Summer School. NITROGEN HETEROCYCLES AS POTENTIAL AGENTS ANTI- ALZHEIMER, Madrid, Espan?a, 2013. 53.

XIX SINAQO. DISEN?O, SI?NTESIS Y ESTUDIO FARMACOLO?GICO DE DIFERENTES AMIDAS DERIVADAS DE CUMARINAS COMO INHIBIDORES DE AChE Y BuChE. Mar del Plata Argentina, 2013. 83.

Workshop in Modern Approaches in Drug Discovery for Neglected Infectious diseases. Instituto Pasteur de Montevideo, Montevideo, Uruguay. Curso. 3-18/Nov- 2014.

16th. BMOS. Experimental and Theoretical Study of phenanthroline- tetrahydroquinolines by Povarov Reaction. Bu?zios, Brazil, 2015. 100, 170.


Comprehensive analysis of crystal structure, spectroscopic properties, quantum chemical insights, and molecular docking studies of two pyrazolopyridine compounds: potential anticancer agents Polo, Efrain; López-Cuellar, Lorena; Acosta-Quiroga, Karen; Rojas-Pena, Cristian; Brito, I; Cisterna, Jonathan; Trilleras, Jorge; Alderete, J; Duarte, Yorley; GUTIERREZ-CABRERA, MARGARITA ISABEL Article SCOPUS RSC ADVANCES (2023)
Direct Oral FXa Inhibitors Binding to Human Serum Albumin: Spectroscopic, Calorimetric, and Computational Studies Marino-Ocampo, Nory; Rodriguez, Diego F.; Guerra Diaz, Daniel; Zuniga-Nunez, Daniel; Duarte, Yorley; Fuentealba, Denis; Zacconi, Flavia C. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases Mendoza-Leon, Maria Jose; Mangalam, Ashutosh K.; Regaldiz, Alejandro; Gonzalez-Madrid, Enrique; Rangel-Ramirez, Ma. Andreina; Alvarez-Mardonez, Oscar; Vallejos, Omar P.; Mendez, Constanza; Bueno, Susan M.; Melo-Gonzalez, Felipe; Duarte, Yorley; Opazo, Ma. Cecilia; Kalergis, Alexis M.; Riedel, Claudia A. Article ISI FRONTIERS IN ENDOCRINOLOGY (2023)
Insights into Early Steps of Decanoic Acid Self-Assemblies under Prebiotic Temperatures Using Molecular Dynamics Simulations Sepulveda, R.V.; Sbarbaro, C.; Opazo, M.C.; Duarte, Y.; González-Nilo, F.; Aguayo, D. Article MEMBRANES (2023)
Multicomponent synthesis and photophysical study of novel α,β-unsaturated carbonyl depsipeptides and peptoids Gonzalez, Ricelia; Murillo-Lopez, Juliana; Rabanal-Leon, Walter; Prent-Penaloza, Luis; Concepcion, Odette; Olivares, Pedro; Duarte, Yorley; de la Torre, Alexander F.; Gutierrez, Margarita; Caballero, Julio Article ISI FRONTIERS IN CHEMISTRY (2023)
Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties Palacios-Prado, Nicolas; Soto, Paola A.; Lopez, Ximena; Choi, Eun Ju; Marquez-Miranda, Valeria; Rojas, Maximiliano; Duarte, Yorley; Lee, Jinu; Gonzalez-Nilo, Fernando D.; Saez, Juan C. Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)
Green by Design: Convergent Synthesis, Computational Analyses, and Activity Evaluation of New FXa Inhibitors Bearing Peptide Triazole Linking Units Rodriguez, Diego F.; Duran-Osorio, Francisca; Duarte, Yorley; Olivares, Pedro; Moglie, Yanina; Dua, Kamal; Zacconi, Flavia C. Article ISI PHARMACEUTICS (2022)
Molecular modeling and structural analysis of some tetrahydroindazole and cyclopentanepyrazole derivatives as COX-2 inhibitors Polo-Cuadrado, Efrain; Acosta-Quiroga, Karen; Rojas-Pena, Cristian; Rodriguez-Nunez, Yeray A.; Duarte, Yorley; Brito, Ivan; Cisterna, Jonathan; Gutierrez, Margarita Article ISI ARABIAN JOURNAL OF CHEMISTRY (2022)
Novel N-benzoylimidazolium ionic liquids derived from benzoic and hydroxybenzoic acids as therapeutic alternative against Biofilm-forming bacteria in skin and soft-tissue infections Forero-Doria, O., Parra-Cid, C., Venturini, W., Espinoza, C., Araya-Maturana, R., Valenzuela-Riffo, F., Saldias, A., Leiva, A., Duarte, Y., Echeverría, J., Guzmán, L Article BIOORGANIC CHEMISTRY (2022)
Synthesis multicomponent based on o‐tolyl‐isocyanide; cholinesterase inhibitors and computational studies Camargo-Ayala, L., Polo-Cuadrado, E., Osorio, E., Soto-Delgado, J., Duarte, Y., Prent-Peñaloza, L., Gutiérrez, M. Article JOURNAL OF MOLECULAR STRUCTURE (2022)
The TGA Transcription Factors from Clade II Negatively Regulate the Salicylic Acid Accumulation in Arabidopsis Fonseca, Alejandro; Urzua, Tomas; Jelenska, Joanna; Sbarbaro, Christopher; Seguel, Aldo; Duarte, Yorley; Greenberg, Jean T.; Holuigue, Loreto; Blanco-Herrera, Francisca; Herrera-Vasquez, Ariel Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Toward the cholinesterase inhibition potential of TADDOL derivatives: Seminal biological and computational studies Constantino, Andrea R.; Charbe, Nitin; Duarte, Yorley; Gutierrez, Margarita; Giordano, Ady; Prasher, Parteek; Dua, Kamal; Mandolesi, Sandra; Zacconi, Flavia C. Article ISI ARCHIV DER PHARMAZIE (2022)
A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII Ximena López; , Nicolas Palacios Prado; Juan Güiza; Rosalba Escamilla; Paola Fernández; José L. Vega; Maximiliano Rojas; Valeria Marquez-Miranda; Eduardo Chamorro; Ana M. Cárdenas; María Constanza Maldifassi; Agustín D. Martínez; Duarte Ayala, Yorley Andrea; Fernando D. González-Nilo; Juan C. Sáez Article Proceedings of the National Academy of Sciences (2021)
Anti-parasitics drugs that modulates non-selective channels formed by connexins or pannexins Juan Güiza, Javiera Arriagada, Luis Rodríguez, Camila Gutiérrez, Yorley Duarte, Juan C. Sáez, José L. Vega, Article BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)
Antimicrobial properties of novel ionic liquids derived from imidazolium cation with phenolic functional groups LuisGuzmán; Crist´obal Parra-Cid; Etiennette Guerrero-Mu˜noz; Carlos Pe˜na-Varas; Efraín Polo-Cuadrado; Duarte Ayala, Yorley Andrea; Ricardo I. Castro; Luz Stella Nerio; Ramiro Araya-Maturana; Tewodros Asefa; Echeverria, Javier; David Ramírez; Forero Doria, Oscar Article BIOORGANIC CHEMISTRY (2021)
Contribution of non-selective membrane channels and receptors in epilepsy Claudia García-Rodríguez; Iván D. Bravo-Tobar; Duarte, Yorley; Luis C. Barrio; Juan C. Sáez Article PHARMACOLOGY THERAPEUTICS (2021)
Development of a PHBV nanoparticle as a peptide vehicle for NOD1 activation Cabana-Brunod, Mauricio; Herrera, Pablo A.; Marquez-Miranda, Valeria; Llancalahuen, Felipe M.; Duarte, Yorley; Gonzalez-Nilo, Danilo; Fuentes, Juan A; Vilos, Cristian; Velasquez, Luis; Otero, Carolina Article ISI DRUG DELIVERY (2021)
Different Classes of Antidepressants Inhibit the Rat α7 Nicotinic Acetylcholine Receptor by Interacting within the Ion Channel: A Functional and Structural Study Duarte, Y.; Rojas, M.; Canan, J.; Pérez, E.G.; González-Nilo, F.; García-Colunga, J. Article MOLECULES (2021)
Cationic Carbosilane Dendritic Systems as Promising Anti-Amyloid Agents in Type 2 Diabetes Lozano-Cruz, Tania; Alcarraz-Vizan, Gema; Javier de la Mata, F.; de Pablo, Sara; Ortega, Paula; Duarte, Yorley; Bravo-Moraga, Felipe; Gonazlez-Nilo, Fernando D.; Novials, Anna; Gomez, Rafael Article ISI CHEMISTRY-A EUROPEAN JOURNAL (2020)
Innovative Three-Step Microwave-Promoted Synthesis of N-Propargyltetrahydroquinoline and 1,2,3-Triazole Derivatives as a Potential Factor Xa (FXa) Inhibitors: Drug Design, Synthesis, and Biological Evaluation Santana-Romo, Fabian; Lagos, Carlos F; Duarte, Yorley; Castillo, Francisco; Moglie, Yanina; Maestro, Miguel A.; Charbe, Nitin; Zacconi., Flavia C. Article ISI SCOPUS MOLECULES (2020)
Novel TRPV1 channel agonists with faster and more potent analgesic properties than capsaicin Yorley Duarte, Javier Cáceres, Romina Sepúlveda, Diego Arriagada, Pedro Olivares, Ignacio Díaz-Franulic, Jimmy Stehberg and Fernando D. González Article FRONTIERS IN PHARMACOLOGY (2020)
PLIDflow: an open-source workflow for the online analysis of protein-ligand docking using galaxy Ulzurrun, Eugenia; Duarte, Yorley; Perez-Wohlfeil, Esteban; Gonzalez-Nilo, Fernando; Trelles, Oswaldo Article ISI BIOINFORMATICS (2020)
Stretch-Induced Activation of Pannexin 1 Channels Can Be Prevented by PKA-Dependent Phosphorylation Lopez, Ximena; Escamilla, Rosalba; Fernandez, Paola; Duarte, Yorley; Gonzalez-Nilo, Fernando; Palacios-Prado, Nicolas; Martinez, Agustin D.; Saez, Juan C. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity Donate-Macian, Pablo; Duarte, Yorley; Rubio-Moscardo, Fanny; Perez-Vilaro, Gemma; Canan, Jonathan; Diez, Juana; Gonzalez-Nilo, Fernando; Valverde, Miguel A. Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2020)
Experimental and Theoretical Approaches in the Study of Phenanthroline-Tetrahydroquinolines for Alzheimer's Disease Duarte, Yorley; Gutierrez, Margarita; Álvarez, Rocío; Alzate?Morales, Jans H.; Soto?Delgado, Jorge Article ISI SCOPUS CHEMISTRYOPEN (2019)
Novel Coumarin-Quinoline Hybrids: Design of Multitarget Compounds for Alzheimer's Disease Duarte, Y; Fonseca, A; Gutierrez, M; Adasme-Carreno, F; Munoz-Gutierrez, C; Alzate-Morales, J; Santana, L; Uriarte, E; Alvarez, R; Matos, MJ Article ISI SCOPUS CHEMISTRYSELECT (2019)
Exploring coumarin potentialities: Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold Fonseca, A; Matos M.J.; Reis, J; Duarte, Y; Gutiérrez M; Santana, L; Uriarte, E; Borges, F Article ISI SCOPUS JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2016)
Tetrahydroquinolines and Isoxazoles: Nitrogen heterocycles as potential antibacterial agents Duarte, Yorley; Dueñas Fernando; Gutiérrez Margarita Article Journal of Chemical and Pharmaceutical Research (2015)
Acción antifúngica del extracto etanólico y sus fracciones de polaridad creciente del epicarpio de lima (Citrus aurantifolia swingle) Duarte, Yorley; Ramírez, Martha Beatriz Article - Revista de la Facultad de Ciencias Básicas de la Universidad del Atlántico (2013)
Crystal structure of 1,3-bis(6-methoxyquinolin-2-yl) benzene, C26H20N2O2 Duarte, Y; Gutiérrez M; Astudillo, L; Brito, I; Cardenas, A; Bolte, M; Lopez-Rodriguez, M Article ISI SCOPUS Zeitschrift fur Kristallographie - New Crystal Structures (2013)
Synthesis of Bistetrahydroquinolines as Potential Anticholinesterasic Agents by Double Diels-Alder Reactions Duarte, Yorley; Gutiérrez, Margarita; Astudillo, Luis; Alzate-Morales, Jans; Valdes, Natalia Article ISI SCOPUS MOLECULES (2013)
X-ray and Hydrogen-bonding Properties of 1-((1H-benzotriazol-1-yl)methyl)naphthalen-2-ol Rivera, Augusto; Duarte, Yorley; Gonzalez-Salas, Diego; Rios-Motta, Jaime; Zaragosa, Guillermo Article ISI MOLECULES (2009)


Nitrogen Heterocycles as Potential Antibacterial Agents Duarte, Yorley; Arevalo, Bárbara; Matus, Francisca; Poblete, Tomás; Gutierrez, Margarita; Astudillo, Luis ConferencePaper (2013)
Synthesis and Study of a Selected Series of Amides with the Coumarin Scaffold for the Treatment of Alzheimer's Disease Fonseca, André; Matos, María; Duarte, Yorley; Gutiérrez, Margarita; Astudillo, Luis; Borges, Fernanda; Uriarte, Eugenio; Santana, Lourdes ConferencePaper (2013)


Desarrollo de una cobertura cutánea costo efectiva “PanexpatchTM” para el tratamiento de úlceras venosas Agustin Martinez Carrasco; Brown, Donald; Caroline Weinstein; Danilo Gonzalez-Nilo, Fernando; Duarte, Yorley; Henriquez, Carlos; Ardiles, Alvaro; Ceriani, Ricardo; Fuentes, Miguel Proyecto (2021)
Desarrollo y producción de encapsulados de embriones de las algas pardas Durvillaea incurvata y Lessonia berteroana, para su aplicación en estrategias de repoblamiento en zonas intermareales Contreras, Loreto; Polanco, Ruben.; Duarte, Yorley; remonsellez, jean pierre Proyecto (2021)
Newly piperazinone derivatives with antithrombotic and anti-inflammatory properties: environmentally-friendly synthesis, characterization, and biological evaluation Duarte, Yorley, Cristian Vilos, Bárbara Herrera Proyecto (2021)
Hybrids of Tetrahydroquinolines as Multi-Target drugs: Design, Synthesis, characterization and biological activity Margarita Gutierrez; Duarte Ayala, Yorley Andrea; Zacconi, Flavia Proyecto (2020)
Innexin2 hemichannels of caligus rogercresseyi as a new target to design antiparasitic agents through in-silico structure-based drug discovery, chemical synthesis and biological assays Duarte, Yorley Proyecto (2020)
Diverse cell types present pannexin1-based gap junction channels with distinct regulatory, functional and pharmacological properties Juan C Saez; Duarte Ayala, Yorley Andrea Proyecto (2019)
Diverse cell types present pannexin1-based gap junction channels with distinct regulatory, functional and pharmacological properties FONDECYT (1191329) Proyecto 2019-2023 Coinvestigador(a)
Formulación y aplicación de una espuma biodegradable e inocua para la mitigación del polvo expulsado en tronaduras mineras Duarte, Yorley; Aguayo, Daniel Proyecto (2019)
FageCapsuleS, bacteriófagos de Salmonella micro-encapsulados con tecnología de liberación intestino grueso y delgado FONDEF (ID18I10235) Proyecto 2018-2020 Investigador(a)
Desarrollo de potenciales Fármacos usando los Astrocitos como blanco farmacológico para el tratamiento de enfermedades psiquiátricas CORFO (14IDL2-30195) Proyecto 2014-2017 Postdoctorado
SYNTHESIS OF DERIVATIVES QUINOLINE-ISOXAZOLE AS INHIBITORS POTENTIALS OF MICROORGANISMS PHYTOPATHOGENIC FONDECYT (1100481) Proyecto 2010-2014 Tesista


Integration of target discovery, drug discovery and drug delivery: A review on computational strategies Duarte Y.; MÃ¡rquez-Miranda V.; Miossec M.J.; GonzÃ¡lez-Nilo F. Review ISI SCOPUS Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology (2019)