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margarita isabel gutierrez cabrera

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

Organic chemistry of heterocycles; Chemistry an biological activity of synthetic compounds; Chemistry and biological activity of natural product, Bioactivity of natural and synthetic compounds, structural elucidation

Chemistry, Universidad de Talca. Chile, 2006

Proffesor Full Time

Universidad de Talca

Institute of Chemistry of Natural Resource

Talca, Chile

2007 - A la fecha

Proffesor Full Time

Universidad de Talca

Talca, Chile

2007 - A la fecha

Undergraduate thesis:

Synthesis and Evaluation of acrylonitrile derivatives as acetylcholinesterase inhibitors. Ljuvica Martinic Gonzalez, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2013.
Derivatives of Benzoacetonitriles as bacterial inhibitors. Maria Natalia Veliz Olivo, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica,Universidad de Talca, 2013.
Synthesis of nitrogen heterocycles and evaluation of their biological activity. Maria Magdalena Sepulveda Espinoza, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2014.
Synthesis of coumarin-quinoline hybrids as selective cholinesterase inhibitors. Rafael Latorre Oyanadel, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2014.
Synthesis of coumarin-quinolines hybrids as potential antioxidant agents. Oliver Orellana Muñoz, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2014.
Synthesis and study of biological activity of quinolin analog heterocycles. Michelle Campos Rodriguez, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2015.
Synthesis, characterization and bioactivity of pyrazole and imidazole systems. Lady Valdés Salas, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2015.
Synthesis of new pyrazole compounds and their biological applications. Patricio Soto Lopez, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica,Universidad de Talca, 2016.
Azorella spinosa phytochemical study. Javiera Olivares Pulgar, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2016.
Synthesis, characterization and bioactivity of ?-? unsaturated systems (chalcones). Nicol Ibarra Arellano, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2016.
Synthesis, characterization and study of biological activity of pyrazolopyrimidines. Valentina Arce Parada, Facultad de Ciencias de la Salud, Escuela de Tecnología Medica, Universidad de Talca, 2016.
Synthesis and evaluation of the antibacterial potential of N-propargyl tetrahydroquinolines derivatives. Maximiliano Norambuena Guzman, Facultad de Ciencias de la Salud, Escuela de Tecnologia Medica, Universidad de Talca,2017.
Effect of lyophilized extracts of Aristotelia chilensis (mol.) Stuntz on the healing activity of mouse fibroblasts NIH-3T3 in vitro. Macarena Jorquera Norambuena, Carlos Segovia Vásquez, Facultad de Ciencias de la Salud, Escuela de Odontología, Universidad de Talca, 2018.

Doctoral thesis
Synthesis of 5,11 epoxieudesmanos (agarofuranos) with insecticidal and antifeedant activity. Evelyn Muñoz, Doctorado en Ciencias Mención Investigación y Desarrollo de Productos Bioactivos, Universidad de Talca (Finalizada) .
Design, synthesis and characterization of pyrazoloquinolinic systems as cholinesterase inhibitors. Efraín Polo. Doctorado en Ciencias Mención Investigación y Desarrollo de Productos Bioactivos, Universidad de Talca (Finalizada).
Estudio de los metabolitos secundarios y proteómica de algunas especies del género Azorella Lam. (Apiaceae). Adriana Jara. Doctorado en Ciencias Mención Investigación y Desarrollo de Productos Bioactivos, Universidad de Talca (Finalizada)
Híbridos de tetrahidroquinolinas/triazoles, posible(s) moléculas(s) multidiana: diseño, síntesis, caracterización y actividad biológica. Meiby Fernandez. Doctorado en Ciencias Mención Investigación y Desarrollo de Productos Bioactivos, Universidad de Talca (en desarrollo)

Postgraduate teaching:
2014-present: Coordinator in the obligatory “Curso de Mecanismo de Acción y ensayos biológicos”” (10 ECTS), Doctorado en Ciencias con Mención en Investigación y Desarrollo de Productos Bioactivos, Instituto de Química de Recursos Naturales, Universidad de Talca.

Undergraduate teaching:

2011-2015: Lecturer in charge of the course “ Chemistry General and Organic", Odontología, Universidad de Talca
2011-2015: Lecturer in charge of the course “ Chemistry General and Organic", Medicina, Universidad de Talca
2016-present: Lecturer in charge of the course “ Inorganic hemistry", Tecnologia Medica, Universidad de Talca
2016-present: Lecturer in charge of the course “ Chemistry", Kinesiologia, Universidad de Talca
2019-2021: Lecturer in charge of the course “ Chemistry ", Obstetricia y Puericultura, Universidad de Talca
2021: Lecturer in charge of the course “ Chemistry ", Bioquimica, Universidad de Talca

Grants

-2006: PROYECTO FIA ES-C-2005-1-A-42 Laboratorio de plantas aromáticas Instituto de Química de Recursos Naturales Universidad de Talca

-2006-2008: Fortalecimiento de la investigación en el instituto de química de recursos naturales” proyecto nº psd-16

-2007-2010: Proyecto anillo: “obtaining natural or hemisintetic products of pharmacological, agrochemical and forestry interest and their possible biotechnological development” Proyecto Nº ACT-38

2008-2010. Research program on cardiovascular disease risk factors (pifrecv).

2011-2013: Fondecyt 1120199: Chemical study of the genus Azorella. Biological activity of its metabolites.

2011-2013: Vac 600569, Universidad de Talca: Synthesis of heterocycles with biological activity.

2013-2015: Fondecyt 1130216: Research on mechanism of antiplatelet action of adenosine and other bioactive compounds from Solanum lycopersicum L.

2014-2015: Fondef Idea:Development and functional evaluation of synthetic inhibitory molecules of potassium channels TASK-3 for the treatment of solid tumors. Proyecto: CA13I10223.

2014: Fondef Idea:In vitro propagation of Rhodophiala pratensis and its use as a source of pharmacologically important alkaloids. Proyecto CA13I10272.

2015-2018 Fondecyt 1150712: Pyrazoloquinolines Derivatives: Synthesis and biological activity
2017-2020: Fondecyt 1170718Design and synthesis of angiotensin-converting enzyme inhibitors using molecular modeling and multicomponent reactions.
2020-2023: Fondecyt 1200531 Hybrids of Tetrahydroquinolines as Multi-Target drugs: Design, Synthesis, characterization and biological activity.

Participation Science Week 2014-2019, Explora Mil Científicos Mil Aulas
Participation Scientific Fairs Explora 2015-2019
Evaluator projects Explora 2015-2019


Molecular modeling and structural analysis of some tetrahydroindazole and cyclopentanepyrazole derivatives as COX-2 inhibitors Polo-Cuadrado, Efraín; Acosta-Quiroga, Karen; Rojas-Peña, Cristian; Rodriguez-Nuñez, Yeray; Duarte, Yorley; Brito, Ivan; Cisterna, Jonathan; Gutierrez, Margarita Article ARABIAN JOURNAL OF CHEMISTRY (2022)
Synthesis Multicomponent Based on o-Tolyl-Isocyanide; Cholinesterase Inhibitors and Computational Studies Camargo-Ayala, Lorena; Polo-Cuadrado, Efraín; Osorio, Edison; Soto-Delgado, Jorge; Duarte, Yorley; Prent-Penaloza, Luis; Gutierrez, Margarita Article JOURNAL OF MOLECULAR STRUCTURE (2022)
Synthesis, characterization, crystal and molecular structure and theoretical study of N-(naphthalen-1-yl)-2-(piperidin-1-yl) acetamide, a selective butyrylcholinesterase inhibitor Camargo-Ayala, Lorena; Prent-Peñaloza, Luis; Polo-Cuadrado, Efraín; Brito, Ivan; Cisterna, Jonathan; Osorio, Edison; Gonzalez, Wendy; Gutierrez, Margarita Article JOURNAL OF MOLECULAR STRUCTURE (2022)
Microwave-assisted synthesis, biological assessment, and molecular modeling of aza-heterocycles: Potential inhibitory capacity of cholinergic enzymes to Alzheimer's disease Polo, Efrain; Prent-Penaloza, Luis; Rodriguez Nunez, Yeray A.; Valdes-Salas, Lady; Trilleras, Jorge; Ramos, Juan; Henao, Jose A.; Galdamez, Antonio; Morales-Bayuelo, Alejandro; Gutierrez, Margarita Article ISI JOURNAL OF MOLECULAR STRUCTURE (2021)
Spirocyclic derivatives as antioxidants: a review Acosta-Qurga, Karen; Rojas-Peña, Cristiian; Nerio, Luz Stella; Gutierrez, Margarita; Polo-Cuadrado, Efraín Article RSC ADVANCES (2021)
Furanyl chalcone derivatives as efficient singlet oxygen quenchers. An experimental and DFT/MRCI study Diaz-Uribe, Carlos; Vallejo, William; Florez, Jiress; Trilleras, Jorge; Gutierrez, Margarita; Rodriguez-Serrano, Angela; Schott, Eduardo; Zarate, Ximena Article ISI TETRAHEDRON (2020)
Insecticidal and cholinesterase activity of dichloromethane extracts of Tithonia diversifolia on Atta cephalotes worker ants (Formicidae: Myrmicinae) Pantoja-Pulido K.D.; RodrÃguez J.; Isaza-MartÃnez J.H.; GutiÃ©rrez-Cabrera M.; Colmenares-Dulcey A.J.; Montoya-Lerma J. Article SCOPUS Insects (2020)
Tetrahydroquinoline-Isoxazole/Isoxazoline Hybrid Compounds as Potential Cholinesterases Inhibitors: Synthesis, Enzyme Inhibition Assays, and Molecular Modeling Studies RodrÃguez NÃºÃ±ez Y.A.; GutÃerrez M.; Alzate-Morales J.; Adasme-CarreÃ±o F.; GÃ¼iza F.M.; Bernal C.C.; Romero BohÃ³rquez A.R. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Bennett acceptance ratio method to calculate the binding free energy of BACE1 inhibitors=> Theoretical model and design of new ligands of the enzyme Margarita Gutiérrez, Gabriel A. Vallejos; Magdalena P. Cortés, Carlos Bustos Article CHEMICAL BIOLOGY AND DRUG DESIGN (2019)
Crystal structure and theoretical studies of 2-bromo-N-(2,4-difluorobenzyl)benzamide; intermediate for the synthesis of phenanthridinone Polo, Efraín; Morales-Bayuelo, Alejandro; Orozco-Ugarriza, Mauricio E.; Henao, José A.; Galdámez, Antonio; Gutierrez, Margarita Article SCOPUS Chemical Data Collections (2019)
Efficient synthesis and antioxidant activity of novel N-propargyl tetrahydroquinoline derivatives through the cationic Povarov reaction Rodriguez Nunez, Yeray A.; Norambuena, Maximiliano; Romero Bohorquez, Arnold R.; Morales-Bayuelo, Alejandro; Gutierrez, Margarita Article ISI HELIYON (2019)
Eugenol supplementation as an additive to improve the thermal stability of Hedychium coronarium Koening essential oil Jiménez Macias, Julyleth P; Castro, Ricardo I; Esguerra, Saray K Gualteros; Marin, Jaime Gallego; Guzman, Luis; Gutierrez, Margarita; Vergara, Claudia E.; Forero-Doria, Oscar Article The Natural Products Journal (2019)
Novel Coumarin-Quinoline Hybrids: Design of Multitarget Compounds for Alzheimer's Disease Duarte, Y; Fonseca, A; Gutierrez, M; Adasme-Carreno, F; Munoz-Gutierrez, C; Alzate-Morales, J; Santana, L; Uriarte, E; Alvarez, R; Matos, MJ Article ISI SCOPUS CHEMISTRYSELECT (2019)
Synthesis of diN-Substituted Glycyl-Phenylalanine Derivatives by Using Ugi Four Component Reaction and Their Potential as Acetylcholinesterase Inhibitors Prent-Penaloza, L; de la Torre, AF; Velazquez-Libera, JL; Gutierrez, M; Caballero, J Article ISI SCOPUS MOLECULES (2019)
Design, facile synthesis, and evaluation of novel spiro- and pyrazolo [1,5-c]quinazolines as cholinesterase inhibitors: Molecular docking and MM/GBSA studies Galvez, J; Polo, S; Insuasty, B; Gutierrez, M; Caceres, D; Alzate-Morales, JH; De-la-Torre, P; Quiroga, J Article ISI SCOPUS COMPUTATIONAL BIOLOGY AND CHEMISTRY (2018)
Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections Forero Doria, Oscar; Castro, Ricardo; Gutierrez, Margarita; Gonzalez Valenzuela, Diego; Santos, Leonardo; Ramirez, David; Guzman, Luis Article ISI SCOPUS MOLECULES (2018)
Semisynthesis, Characterization and Evaluation of New Adenosine Derivatives as Antiproliferative Agents Zurita, FV; Vega, NB; Gutierrez Cabrera, M Article ISI SCOPUS MOLECULES (2018)
Microwave-assisted one-pot synthesis in water of carbonylpyrazolo[3,4-b] pyridine derivatives catalyzed by InCl3 and sonochemical assisted condensation with aldehydes to obtain new chalcone derivatives containing the pyrazolopyridinic moiety Polo, E; Ferrer-Pertuz, K; Trilleras, J; Quiroga, J; Gutierrez, M Article ISI SCOPUS JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2017)
N-{4-[(2E)-3-(2H-1,3-Benzodioxol-5-yl)prop-2-enoyl]phenyl}quinoline-3-carboxamide Polo, E; Trilleras, J; Cabrera, MG Article WOS-ESCI SCOPUS MolBank (2017)
Synthesis of novel 7-aryl and 7-spiropyrazolo[4 ',3 ':5,6]pyrido [2,3-d]pyrimidine derivatives and their study as AChE inhibitors Acosta P.; Insuasty B.; Abonia R.; Gutierrez M.; Quiroga J. Article ISI SCOPUS MOLECULAR DIVERSITY (2017)
Antimicrobial and degradative bacterial dna effects of new 2-alkyl (Tetrahydroquinoline-4-yl) formamide Espitia-Almeida F.; Meléndez C.M.; Ochoa-Díaz M.; Valle-Molinares R.; Gutiérrez M; Gómez, D. Article SCOPUS Pharmacologyonline (2016)
Crystal structure of (E)-2-(benzo[d]thiazol-2-yl)-3-(pyridin-3-yl)acrylonitrile) De-La-Torre, P; Gutiérrez M; Caballero, J; Trilleras, J; Astudillo, L; Cardenas, A; Brito, I Article ISI SCOPUS ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES (2016)
Efficient MW-Assisted Synthesis, Spectroscopic Characterization, X-ray and Antioxidant Properties of Indazole Derivatives Polo, E; Trilleras, J; Ramos, J; Galdamez, A; Quiroga, J; Gutierrez, M Article ISI SCOPUS MOLECULES (2016)
Exploring coumarin potentialities: Development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold Fonseca, A; Matos M.J.; Reis, J; Duarte, Y; Gutiérrez M; Santana, L; Uriarte, E; Borges, F Article ISI SCOPUS JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2016)
Monitoring and mechanisms of organophosphate resistance in San Jose scale, Diaspidiotus perniciosus (Hemiptera=> Diaspididae) Buzzetti, KA; Chorbadjian, RA; Fuentes-Contreras, E; Gutierrez, M; Rios, JC; Nauen, R Article Journal of Applied Entomology (2016)
Novel N-allyl/propargyl tetrahydroquinolines=> Synthesis via Three-component Cationic Imino Diels-Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors Rodriguez, Yeray A. Gutierrez; Margarita, Ramirez; David, Alzate-Morales; Jans, Bernal; Cristian C., Gueiza; Fausto M., Romero Bohorquez Article CHEMICAL BIOLOGY AND DRUG DESIGN (2016)
Synthesis and in silico analysis of the quantitative structure-activity relationship of heteroaryl-acrylonitriles as AChE inhibitors De-La-Torre, P; Treuer, AV; Gutiérrez M; Poblete, H.; Alzate-Morales, JH; Trilleras, J; Astudillo Saavedra L.; Caballero, J Article ISI SCOPUS Revista Mexicana de Urologia (2016)
• Synthesis and in silico analysis of the quantitative structure activity relationship of heteroaryl–acrylonitriles as AChE inhibitors. De-la Torre Pedro, .Treuer Adriana V, Gutierrez Margarita, Poblete Horacio, .Alzate-Morales Gutierrez, Horacio Poblete, Alzate-Morales Jans, Trilleras Jorge, Astudillo-Saavedra Luis, Caballero Julio. Article Journal of the Taiwan Institute of Chemical Engineers (2016)
Dihydroagarofuranoid Sesquiterpenes as Acetylcholinesterase Inhibitors from Celastraceae Plants: Maytenus disticha and Euonymus japonicus Alarcon J.; Céspedes C.L.; Muñoz E; Balbontin, C; Valdes, F; Gutiérrez M; Astudillo, L; Seigler D.S. Article ISI SCOPUS Journal of Agricultural and Food Chemistry (2015)
Molecular Docking Studies of the Antitumoral Activity and Characterization of New Chalcone San-Martín Aurelio; Donoso Viviana; Leiva Sergio; Mitchell Bacho; Núñez Solange; Gutierrez Margarita; Rovirosa Juana; Bailón-Moscoso Natalia; Cuenca Camacho Sandra; Malagón Aviles Omar and Cazar María-Elena. Article Current Topics in Medicinal Chemistry (2015)
Nano-Detoxification of Organophosphate Agents by PAMAM Derivatives Duran-Lara, EF; Avila-Salas, F; Galaz S.; John A.; Marican, A.; Gutiérrez M; Nachtigall, FM; Gonzalez-Nilo, FD; Santos, LS Article ISI SCOPUS JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY (2015)
• Synthesis, molecular docking and design of Tetrahydroquinolines as acetylcholinesterase inhibitors Gutiérrez Margarita ; Arévalo Bárbara ; Martínez Gonzalo; Valdés Francisco ; Vallejos Gabriel; Carmona Unai; and San Martin Aurelio Article Journal of Chemical and Pharmaceutical Research (2015)
• Tetrahydroquinolines and Isoxazoles: Nitrogen heterocycles as potential antibacterial agents Duarte Yorley; Dueñas Fernando and Gutiérrez Margarita Article Journal of Chemical and Pharmaceutical Research, (2015)
A New Isoxazolic Compound Acts as alpha 7 Nicotinic Receptor Agonist in Human Umbilical Vein Endothelial Cells CORTES, MP; Alvarez R.; Sepulveda E.; Jimenez-Aspee, F; Astudillo, L; Vallejos G.; Gutiérrez M Article ISI SCOPUS ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES (2014)
Antioxidant activity of bioactive extracts obtained from rhizomes of cyperus digitatus roxb [Actividad antioxidante de extractos obtenidos a partir de rizomas de cyperus digitatus roxb] Forero-Doria O.; Astudillo, L; Castro, R. I.; Lozano R.; Díaz O.; Guzmán-Jofre L.; Gutiérrez M Article SCOPUS Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2014)
Biodiesel production from an industrial residue: Alperujo Hernandez, D; Astudillo, L; Gutiérrez M; Tenreiro, C.; Retamal, C; Rojas C. Article ISI SCOPUS INDUSTRIAL CROPS AND PRODUCTS (2014)
E-2-(Benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles as effecient Michael acceptors for cystein: real application in biological imaging. Pedro De la Torre, Olimpo Garcia-Beltran, William Tiznado, Natalia Mena, Luis Astudillo Saavedra, Margarita Gutierrez Cabrera, Jorge Trilleras, Paulina Pavez, Margarita E. Aliaga Article Sensors and Actuators B: Chemical (2014)
Effect of tomato industrial processing (different hybrids, paste, and pomace) on inhibition of platelet function in vitro, ex vivo, and in vivo. Rodríguez-Azúa, Rosio; Treuer, Adriana; Moore-Carrasco, Rodrigo; Cortacáns, Daniel; Gutiérrez, Margarita; Astudillo, Luis; Fuentes, Eduardo; Palomo, Iván Article Journal of medicinal food (2014)
New Diterpenes from Azorella spinosa Astudillo, L; Gutiérrez M; Quesada, L; San Martin, A; Espinoza L.; Peñailillo P. Article ISI NATURAL PRODUCT COMMUNICATIONS (2014)
Synthesis of New 3-(2-Chloroquinolin-3-yl)-5-Phenylisoxazole Derivatives via Click-Chemistry Approach Fernandez-Galleguillos, C; Saavedra, LA; Gutiérrez M Article ISI JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY (2014)
Synthetic isoxazole as antiplatelet agent Gutierrez, Margarita; Amigo, Jessica; Fuentes, Eduardo; Palomo, Ivan; Astudillo, Luis Article PLATELETS (2014)
Ultrasound-assisted phase-transfer catalysis in ana aqueous medium to promote the Knoevenagel reaction: Advantages over the conventional and microwave-assisted solvent-free/catalyst-free method. Pedro de la Torre; Edison Osorio; Jans alzate-Morales; Julio Caballero; Jorge Trilleras; Luis Astudillo; Ivan Brito; Alejandro Cardenas; Jairo Quiroga; Margarita Gutierrez Article Ultrasonic Sonochemistry (2014)
Antioxidant and Antiplatelet Activities in Extracts from Green and Fully Ripe Tomato Fruits (Solanum lycopersicum) and Pomace from Industrial Tomato Processing Fuentes E.; Carle, R; Astudillo, L; Guzman, L; Gutiérrez M; Carrasco, G; Palomo I. Article ISI SCOPUS Evidence-based Complementary and Alternative Medicine (2013)
Crystal structure of 1,3-bis(6-methoxyquinolin-2-yl) benzene, C26H20N2O2 Duarte, Y; Gutiérrez M; Astudillo, L; Brito, I; Cardenas, A; Bolte, M; Lopez-Rodriguez, M Article ISI SCOPUS Zeitschrift fur Kristallographie - New Crystal Structures (2013)
Determination of antibacterial, antioxidant, antiplatelet and inhibition of cholinesterase activities from the methanolic extracts of Azorella species (Apiaceae) Quesada, L; Gutiérrez M; Astudillo, L; San Martin, A; Fuentes E.; Palomo I.; Peñailillo P. Article ISI BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2013)
Isoxazoles: synthesis, evaluation and bioinformatic design as acetylcholinesterase inhibitors Gutiérrez M; Matus, MF; Poblete, T; Amigo, J; Vallejos G.; Astudillo, L Article ISI SCOPUS Journal of Pharmacy and Pharmacology (2013)
Synthesis of Bistetrahydroquinolines as Potential Anticholinesterasic Agents by Double Diels-Alder Reactions Duarte, Yorley; Gutiérrez, Margarita; Astudillo, Luis; Alzate-Morales, Jans; Valdes, Natalia Article ISI SCOPUS MOLECULES (2013)
A Novel Class of Selective Acetylcholinesterase Inhibitors: Synthesis and Evaluation of (E)-2-(Benzo[d]thiazol-2-yl)-3- heteroarylacrylonitriles Pedro De La Torre; Julio Caballero; Jairo Quiroga; Jans Alzate; Margarita Gutierrez; jorge Trilleras; Luis Astudillo Article Molecules (2012)
Antifungal Activity of Tetrahydroquinolines against Some Phytopathogenic Fungi Gutiérrez M; Carmona U.; Vallejos G.; Astudillo, L Article ISI ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES (2012)
Bioassay-Guided Isolation and HPLC Determination of Bioactive Compound That Relate to the Antiplatelet Activity (Adhesion, Secretion, and Aggregation) from Solanum lycopersicum Fuentes E.; Castro R.; Astudillo, L; Carrasco, G; Alarcon M.; Gutiérrez M; Palomo I. Article ISI SCOPUS Evidence-based Complementary and Alternative Medicine (2012)
Biological Activity of Isoflavonoids from Azorella madreporica Quesada, L; Areche, C; Astudillo, L; Gutiérrez M; Sepúlveda B.; San Martin, A Article ISI SCOPUS Natural Product Communications (2012)
Fractions of aqueous and methanolic extracts from tomato (Solanum lycopersicum L.) present platelet antiaggregant activity Fuentes E.J.; Astudillo L.A.; Gutierrez M.I.; Contreras S.O.; Bustamante L.O.; Rubio P.I.; Moore-Carrasco, R; Alarcón M.A.; Fuentes, J. A.; Gonzalez D.E.; Palomo I.F. Article ISI SCOPUS Blood Coagulation and Fibrinolysis (2012)
SYNTHESIS AND AChE INHIBITING ACTIVITY OF 2, 4 SUBSTITUTED 6-PHENYL PYRIMIDINES Paz, C; Peter M.G.; Schmidt, B; Becerra, J. ; Gutiérrez M; Astudillo, L; Silva M. Article ISI SCIELO SCOPUS Journal of the Chilean Chemical Society (2012)
1-[2-(4-Nitrophenyl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one Gutiérrez M; Astudillo, L; Quesada, L; Brito, I; Lopez-Rodriguez, M Article ISI SCOPUS Acta Crystallographica Section E: Structure Reports Online (2011)
1-[2-(4-Nitrophenyl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one monohydrate Gutiérrez M; Vallejos G.; Fernandez, C.; Cardenas, A; Brito, I Article ISI SCOPUS Acta Crystallographica Section E: Structure Reports Online (2011)
Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables Torres-Urrutia C.; Guzman, L; Schmeda-Hirschmann, G; Moore-Carrasco, R; Alarcon M.; Astudillo, L; Gutiérrez M; Carrasco, G; Yuri, JA.; Aranda, E; Palomo I. Article ISI SCOPUS Blood Coagulation and Fibrinolysis (2011)
13-EPI-NEOCLERODANES FROM BACCHARIS MARGINALIS San Martin, A; Astudillo, L; Gutiérrez M; Chamy, MC; Orejarena S.; rivera, p; Vergara K. Article ISI SCIELO JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2010)
Quinoline-based compounds as modulators of HIV transcription through NF-kappa B and Sp1 inhibition Bedoya, LM; Abad, MJ; Calonge, E; Saavedra, LA; Gutiérrez M; Kouznetsov, VV; Alcami, J; Bermejo, P Article ISI SCOPUS Antiviral Research (2010)
Synthesis of New Diversely Linked Biquinoline Derivatives by Multicomponent Imino-Diels-Alder Cycloaddition and Intramolecular Friedel-Crafts Cyclization Saavedra, LA; Vallejos G.; Kouznetsov, VV; Gutiérrez M; Gomez, CMM; Mendez, LYV; Jaimes, JHB Article ISI SCOPUS Synthesis (Germany) (2010)
1-(3-Phenylisoxazol-5-yl)cyclohexane-1,2-diol Astudillo, L; Brito, I; Vallejos G.; Gutiérrez M; Lopez-Rodriguez, M Article ISI SCOPUS ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE (2009)
5-(1-Cyclohexen-1-yl)-3-(4-methoxyphenyl)isoxazole Vallejos G.; Gutiérrez M; Astudillo, L; Brito, I; Cardenas, A Article ISI SCOPUS ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE (2009)
Solvent-Free Microwave-Assisted Synthesis of New 2-Aryl-Tetrahydroquinolines Using Three-Component Povarov Reaction Astudillo, LS; Gutiérrez M; Gaete, H; Kouznetsov, VV; Melendez, CM; Palenzuela, JA; Vallejos G. Article ISI SCOPUS Letters in Organic Chemistry (2009)
Synthesis and Biotransformation of Tetrahydroquinoline by Mortierella isabelina Astudillo, L; de la Guarda, W; Gutiérrez M; San Martin, A Article ISI SCOPUS ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES (2009)
TRITERPENOIDS FROM Azorella trifurcata (Gaertn.) Pers AND THEIR EFFECT AGAINST THE ENZYME ACETYLCHOLINESTERASE Areche, C; Cejas, P; Thomas P.; San Martin, A; Astudillo, L; Gutiérrez M; Loyola, LA Article ISI SCOPUS QUIMICA NOVA (2009)
Inhibition of Acetylcholinesterase Activity by Dihydro-beta-agarofuran Sesquiterpenes Isolated from Chilean Celastraceae Alarcon J.; Astudillo, L; Gutiérrez M Article ISI ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES (2008)
Bioactive metabolites from the fungus Nectria galligena, the main apple canker agent in Chile Gutiérrez M; Theoduloz, C; Rodriguez J.; Lolas M.; Schmeda-Hirschmann, G Article ISI SCOPUS JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2005)
BIOLOGICALLY ACTIVE COMPOUNDS FROM CHILEAN PROPOLIS Astudillo, L; Ávila F.; Morrison R.; Gutiérrez M; Bastida, J.; CODINA, C; Schmeda-Hirschmann, G Article ISI SCIELO SCOPUS BOLETIN DE LA SOCIEDAD CHILENA DE QUIMICA (2000)


Obituary Luis Armando Astudillo Saavedra [Calama 1960-Talca 2013], has works published, Researcher Gutiérrez M; Alarcon J. BiographicalItem ISI BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2014)


Design and synthesis of angiotensin-converting enzyme inhibitors using molecular modeling and multicomponent reactions FONDECYT (1170718) Proyecto 2017-2020 Coinvestigador(a)
Pyrazoloquinolines derivatives=> synthesis and biological activity FONDECYT (1150712) Proyecto 2015-2018 Inv. Principal
Desarrollo y evaluacion funcional de moleculas sinteticas inhibidoras de los canales de potasio task-3 para el tratamiento de tumores solidos. FONDEF (CA13I10223) Proyecto 2014-2015 Coinvestigador(a)
Propagacion in vitro de Rhodophiala pratensis y su uso como Fuente de alcaloides de importancia farmacologica. FONDEF (CA13I1027) Proyecto 2014-2015 Coinvestigador(a)
Research on mechanism of antiplatelet action of adenosine and other bioactive compounds from Solanum lycopersicum L. FONDECYT (1130216) Proyecto 2013-2015 Coinvestigador(a)
SÍNTESIS DE NUEVOS HÍBRIDOS MOLECULARES ENTRE SISTEMAS TETRAHIDROQUINOLÍNICOS E ISOXAZOLES/ISOXAZOLINAS COMO POSIBLES AGENTES ANTI PROTOZOARIOS Y FITOPATOGENOS PCI (2012 – 005) Proyecto 2013-2014 Inv. Principal
Chemical study of the genus azorella. Biological activity of its metabolites. FONDECYT (1120199) Proyecto 2011-2013 Coinvestigador(a)


Adenosine: Synthetic methods of its derivatives and antitumor activity ValdÃ©s F.Z.; Luna V.Z.; ArÃ©valo B.R.; Brown N.V.; GutiÃ©rrez M.C. Review ISI SCOPUS (2018)

margarita gutierrez

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

Gabriel Vallejos

Académico

UNIVERSIDAD ASUTRAL DE CHILE

Valdivia, Chile

Ivan Brito

Full Professor

Chemsitry

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

AURELIO SAN MARTIN

Profesor Asociado (media jornada)

de Ciencias y Recursos Naturales

FACULTAD DE CIENCIAS

Punta Arenas, Chile

Iván Palomo

Hematology Professor

Clinical Biochemistry and Immunohematology

UNIVERSIDAD DE TALCA

Talca, Chile

Ivan Brito

Profesor Titular

Quimica

Universidad de Antofagasta

Antofagasta, Chile

YORLEY DUARTE

profesor Asistente

Universidad Andrés Bello

Santiago, Chile

Marcelo Alarcón

Profesor

Bioquimica Clinica e Inmunahematologia

UNIVERSIDAD DE TALCA

Talca, Chile

Efrain Polo

Docente

Universidad de Talca

Talca, Chile

Luisa Quesada

Docente e investigadora

Nutrición y Dietética

Universidad San Sebastián

Valdivia, Chile

Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

Eduardo Fuentes

Profesor Titular

Universidad de Talca

Talca, Chile

Rodrigo Moore

Profesor Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

Ricardo Castro

investigador

Instituto de ciencias químicas aplicadas

Universidad Autonomade Chile

Talca, Chile

Julio Alarcón

Docente

Ciencias Básicas

UNIVERSIDAD DEL BÍO-BÍO

Chillan, Chile

Luis Guzman

Profesor Asistente

Departamento Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

Gilda Carrasco

PROFESOR TITULAR

HORTICULTURA

UNIVERSIDAD DE TALCA

Talca, Chile

LEONARDO SILVA

PROFESOR TITULAR

UNIVERSIDAD DE TALCA

TALCA, Chile

Francisco Adasme

Asistente de Investigación

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Nelson Brown

Associate Professor

University of Talca

Talca, Chile

Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Guillermo Schmeda

Profesor Titular

UNIVERSIDAD DE TALCA

Talca, Chile

Oscar Forero

Asesor científico

Instituto de química de productos naturales

Universidad de Talca

Talca, Chile

Carlos Fernández

Académico

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

Alexander Fernández

Profesor Asistente

Química Orgánica

Universidad de Concepción

Concepción, Chile

Fabián Avila

INVESTIGADOR

FACULTAD DE CIENCIAS

UNIVERSIDAD MAYOR

Santiago, Chile

Cristian Balbontin

Investigador

Produccion Vegetal

Instituto de Investigaciones Agropecuarias

Chillán, Chile

Rocio Alvarez

Cristian Paz

Académico

Ciencias Químicas

Universidad de La Frontera

Temuco, Chile

Horacio Poblete

Profesor Conferenciante

Universidad de Talca

Talca, Chile

Diógenes Hernández

Conferenciante

Instituto de química de recursos naturales

Universidad de Talca

Curico, Chile

Adolfo Marican

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

MAURICIO LOLAS

Investigador

Producción Agrícola

Universidad de Talca

Talca, Chile

Jose Yuri

Profesor Titular y Director del Centro de Pomáceas

Producción Agrícola

UNIVERSIDAD DE TALCA

Talca, Chile

Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

Luis Espinoza

Assistant Professor

Chemistry

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaíso, Chile

John Amalraj

Professor Assistant

Instituto de Quimica de Recursos Naturales

Universidad de Talca

Talca, Chile

ANTONIO GALDAMEZ

ASSOCIATE PROFESSOR

CHEMISTRY

DEPARTAMENTO DE QUÍMICA, FACULTAD DE CIENCIA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Natalia Valdés

Investigador

Universidad de Santiago de Chile

Santiago, Chile

Cesar Retamal

Profesor Conferenciante

Departamento de Ingeniería y Gestión de la en Construcción

UNIVERSIDAD DE TALCA

Curicó, Chile

Mario Silva

Emeritus Professor

Botany Department

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

JOSE BECERRA

Professor

Botany Department

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Horacio Poblete

Profesor Conferenciante

UNIVERSIDAD DE TALCA

Talca, Chile

DANIEL GONZALEZ

PROFESOR ASOCIADO

CIENCIAS BASICAS BIOMEDICAS

UNIVERSIDAD DE TALCA

Talca, Chile

Fernando Avila

Graduate Researcher / PhD Student

Cirugía y Cancer

Imperial College London

London, Reino Unido

Esteban Durán

Associate Professor

Depto de Microbiologia

UNIVERSIDAD DE TALCA

Talca, Chile

Eduardo Aranda

Biochemist

Hematology

P. UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Claudio Tenreiro

Decano

Departamento de Tecnologías Industriales

Universidad de Talca

Talca, Chile

Bárbara Arévalo

Investigador

Investigación

Centro de Estudios de Alimentos Procesados

Talca, Chile

José Velázquez

Académico Investigador de la Planta no Regular

Ingeniería Civil en Bioinformática

Universidad de Talca

Talca, Chile

Oscar Forero

Investigador

Instituto de Química de Recursos Naturales

Universidad de Talca

Talca, Chile

Hernán Gaete

Profesor

Escuela de Ingeniería en Medioambiente

Universidad de Valparaíso

Valparaíso, Chile

Eduardo Schott

Profesor Asociado

Departamento de Química Inorgánica

Pontificia Universidad Católica de Chile

Santiago, Chile

Ximena Zarate

Associate Profesor

Instituto de Ciencias Químicas Aplicadas

Universidad Autónoma de Chile

Santiago, Chile

MAGDALENA CORTES

Académico

Universidad de Valparaíso

Valparaíso, Chile

Evelyn Muñoz

Post Doctorante

Ciencias Naturales y Exactas

Universidad de Playa Ancha de Ciencias de la Educación

Valparaíso, Chile

margarita isabel gutierrez cabrera

Líneas de Investigación

Educación

Chemistry, Universidad de Talca. Chile, 2006

Experiencia Académica

Proffesor Full Time

Experiencia Profesional

Proffesor Full Time

Formación de Capital Humano

Difusión y Transferencia

Article (67)

BiographicalItem (1)

Proyecto (7)

Design and synthesis of angiotensin-converting enzyme inhibitors using molecular modeling and multicomponent reactions

Pyrazoloquinolines derivatives=> synthesis and biological activity

Desarrollo y evaluacion funcional de moleculas sinteticas inhibidoras de los canales de potasio task-3 para el tratamiento de tumores solidos.

Propagacion in vitro de Rhodophiala pratensis y su uso como Fuente de alcaloides de importancia farmacologica.

Research on mechanism of antiplatelet action of adenosine and other bioactive compounds from Solanum lycopersicum L.

SÍNTESIS DE NUEVOS HÍBRIDOS MOLECULARES ENTRE SISTEMAS TETRAHIDROQUINOLÍNICOS E ISOXAZOLES/ISOXAZOLINAS COMO POSIBLES AGENTES ANTI PROTOZOARIOS Y FITOPATOGENOS

Chemical study of the genus azorella. Biological activity of its metabolites.

Review (1)