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Cristian Fabián Paz Robles

Académico

Universidad de La Frontera

Temuco, Chile

Líneas de Investigación


Química Medicinal Química de Productos Naturales Síntesis y hemisintesis de compuestos bioactivos Análisis funcional de compuestos activos mediante biología molecular .

Educación

  •  Quimica, UNIVERSIDAD DE CONCEPCION. Chile, 2012
  •  Pedagogía en Química, UNIVERSIDAD DE CONCEPCION. Chile, 2007
  •  Quimico Analista, UNIVERSIDAD DE CONCEPCION. Chile, 2003

Experiencia Académica

  •   Académico Full Time

    UNIVERSIDAD DE LA FRONTERA

    Ingenieria y Ciencias

    Temuco, Chile

    2014 - A la fecha

  •   Académico Full Time

    UNIVERSIDAD DE LA FRONTERA

    Medicina

    Temuco, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Operador Full Time

    UDT Unidad de Desarrollo Tecnológico UdeC

    Coronel, Chile

    2004 - 2004

Formación de Capital Humano


Tesis de Pregrado : 1



 

Article (39)

Antifungal Effects of Drimane Sesquiterpenoids Isolated from Drimys winteri against Gaeumannomyces graminis var. tritici

Paz, Cristian; Viscardi, Sharon; Iturra, Andres; Marin, Victor; Miranda, Felipe; Javier Barra, Patricio; Mendez, Isabel; Duran, Paola

Article ISI
APPLIED AND ENVIRONMENTAL MICROBIOLOGY  (2020)

Drimenol, isodrimeninol and polygodial isolated from Drimys winteri reduce monocyte adhesion to stimulated human endothelial cells

Burgos, Viviana; Paz, Cristian; Saavedra, Kathleen; Saavedra, Nicolas; Foglio, Mary Ann; Salazar, Luis A.

Article ISI
FOOD AND CHEMICAL TOXICOLOGY  (2020)

Drimys winteri and isodrimeninol decreased foam cell formation in THP-1 derived macrophages

Burgos, Viviana; Paz, Cristian; Saavedra, Kathleen; Saavedra, Nicolas; Foglio, Mary Ann; Gonzalez-Chavarria, Ivan; Salazar, Luis A.

Article ISI
FOOD AND CHEMICAL TOXICOLOGY  (2020)

Maytenus disticha Extract and an Isolated beta-Dihydroagarofuran Induce Mitochondrial Depolarization and Apoptosis in Human Cancer Cells by Increasing Mitochondrial Reactive Oxygen Species

González-Chavarría, Iván; Duprat, Felix; Roa, Francisco J.; Jara, Nery; Toledo, Jorge R.; Miranda, Felipe; Becerra, José; Inostroza, Alejandro; Kelling, Alexandra; Schilde, Uwe; Heydenreich, Matthias; Paz, Cristian

Article ISI SCOPUS
BIOMOLECULES  (2020)

Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against Candida Yeast by Inhibition of Lanosterol 14-Alpha Demethylase

Marin, Victor; Iturra, Andres; Opazo, Andres; Schmidt, Bernd; Heydenreich, Matthias; Ortiz, Leandro; Jimenez, Veronica A.; Paz, Cristian

Article ISI
BIOMOLECULES  (2020)

PHYTOCHEMICAL AND CRYSTALLOGRAPHIC STUDIES OF Azara dentata EXTRACTS AND ITS CYTOTOXIC EFFECTS ON HUMAN BREAST CANCER CELL, MCF-7

Paz, Cristian; Gonzalez-Chavarria, Ivan; Freire, Eleonora; Ortiz, Leandro; Karpinski, Tomasz M.; Duprat, Felix; Baggio, Ricardo

Article ISI SCIELO
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY  (2020)

ADSORPTION ABILITY OF ACTIVATED CARBON OBTAINED FROM SUB-BITUMINOUS COAL (LEBU, CHILE) TO CAPTURE TRIMETHYLAMINE

Méndez, Paola; Nuñez, Christian; Cabrera-Pardo, Jaime R.; Paz, Cristian; Barraza, Juan Manuel; Castillo, Rosario; Peña-Farfal, Carlos

Article ISI SCIELO SCOPUS
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY  (2019)

Alkaloids Purified from Aristotelia chilensis Inhibit the Human alpha 3 beta 4 Nicotinic Acetylcholine Receptor with Higher Potencies Compared with the Human alpha 3 beta 4 and alpha 7 Subtypes

Arias H.R.; Ortells M.O.; Feuerbach D.; Burgos V.; Paz C.

Article ISI SCOPUS
JOURNAL OF NATURAL PRODUCTS  (2019)

Aristotelia chilensis (Mol.) Stuntz: A Natural Source of Bioactive Compounds

Turchetti, Giovanni; Paz, Cristian

Article WOS-ESCI
CURRENT TRADITIONAL MEDICINE  (2019)

Aristoteline, an Indole-Alkaloid, Induces Relaxation by Activating Potassium Channels and Blocking Calcium Channels in Isolated Rat Aorta

Romero, Fernando; Palacios, Javier; Jofre, Ignacio; Paz, Cristian; Nwokocha, Chukwuemeka R.; Paredes, Adrian; Cifuentes, Fredi

Article ISI SCOPUS
MOLECULES  (2019)

Exposure to UV-B Radiation Leads to Increased Deposition of Cell Wall-Associated Xerocomic Acid in Cultures of Serpula himantioides

Torres, Solange; González-Ramírez, Mariela; Gavilán, Javiera; Paz, Cristian; Palfner, Goetz; Arnold, Norbert; Fuentealba, Jorge; Becerra, José; Pérez, Claudia; Cabrera-Pardo, Jaime R.; Druzhinina, Irina S.

Article ISI SCOPUS
APPLIED AND ENVIRONMENTAL MICROBIOLOGY  (2019)

Occurrence of Soil Fungi in Antarctic Pristine Environments

Durán, Paola; Barra, Patricio J.; Jorquera, Milko A.; Viscardi, Sharon; Fernandez, Camila.; Paz, Cristian; Mora, María de la Luz; Bol, Roland

Article ISI SCOPUS
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY  (2019)

8-Oxo-9-Dihydromakomakine Isolated from Aristotelia chilensis Induces Vasodilation in Rat Aorta: Role of the Extracellular Calcium Influx

Cifuentes, Fredi; Palacios, Javier; Paredes, Adrian; Nwokocha, Chukwuemeka R.; Paz, Cristian

Article ISI SCOPUS
MOLECULES  (2018)

Assessment of insecticidal responses of extracts and compounds of Drimys winteri, Lobelia tupa, Viola portalesia and Vestia foetida against the granary weevil Sitophilus granarius

Paz, C; Burgos, V; Iturra, A; Rebolledo, R; Ortiz, L; Baggio, R; Becerra, J; Cespedes-Acuna, CL

Article ISI SCOPUS
INDUSTRIAL CROPS AND PRODUCTS  (2018)

Drimane Sesquiterpenoids Noncompetitively Inhibit Human alpha 4 beta 2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human alpha 3 beta 4 and alpha 7 Subtypes

Arias, Hugo R.; Feuerbach, Dominik; Schmidt, Bernd; Heydenreich, Matthias; Paz, Cristian; Ortells, Marcelo O.

Article ISI SCOPUS
JOURNAL OF NATURAL PRODUCTS  (2018)

Three new dihydro-beta-agarofuran sesquiterpenes from the seeds of Maytenus boaria

Paz, Cristian; Heydenreich, Matthias; Schmidt, Bernd; Vadra, Nahir; Baggio, Ricardo

Article ISI SCOPUS
ACTA CRYSTALLOGRAPHICA SECTION C: CRYSTAL STRUCTURE COMMUNICATIONS  (2018)

TrypanocidalActivity of Natural Sesquiterpenoids Involves Mitochondrial Dysfunction, ROS Production and Autophagic Phenotype in Trypanosoma cruzi

Souza Bombaca, Ana Cristina; Von Dossow, Daniela; Chaves Barbosa, Juliana Magalhaes; Paz, Cristian; Burgos, Viviana; Sadok Menna-Barreto, Rubem Figueiredo

Article ISI SCOPUS
MOLECULES  (2018)

A dihydro-beta-agarofuran sesquiterpene from Maytenus boaria

Paz C.; Von Dossow D.; Tiznado V.; Suarez S.; Cukiernik F.D.; Baggio R.

Article ISI SCOPUS
ACTA CRYSTALLOGRAPHICA SECTION C: CRYSTAL STRUCTURE COMMUNICATIONS  (2017)

Antibiotic activity of Emerimicin IV isolated from Emericellopsis minima from Talcahuano Bay, Chile

Inostroza A.; Lara L.; Paz C.; Perez A.; Galleguillos F.; Hernandez V.; Becerra J.; González-Rocha G.; Silva M.

Article SCOPUS
Natural Product Research  (2017)

Crystal structure of erioflorin isolated from Podanthus mitiqui (L.).

Paz Robles, Cristian; Schilde, Uwe

Article ISI
Acta Cryst.  (2017)

Effects of extracts from Maytenus on Aegorhinus superciliosus (Coleoptera: Curculionidae) and Hippodamia convergens (Coleoptera: Coccinellidae)

Zavala, A; Hormazabal, E; Montenegro, G; Rosalez, M; Quiroz, A; Paz, C; Rebolledo, R

Article ISI SCOPUS
Revista Colombiana de Entomologia  (2017)

Inhibition on cholinesterase and tyrosinase by alkaloids and phenolics from Aristotelia chilensis leaves

Cespedes C.L.; Balbontin C.; Avila J.G.; Dominguez M.; Alarcon J.; Paz C.; Burgos V.; Ortiz L.; Peñaloza-Castro I.; Seigler D.S.; Kubo I.

Article ISI SCOPUS
FOOD AND CHEMICAL TOXICOLOGY  (2017)

(?)-8-oxohobartine a new ?ndole alkaloid from aristotelia chilensis (Mol.) Stuntz

Paz, C; Becerra, J. ; Silva M.; Cabrera-Pardo J.; Burgos, V.; Heydenreich, M; Schmidt, B

Article SCOPUS
Records of Natural Products  (2016)

(-)-8-oxohobartine a new indole alkaloid from Aristotelia chilensis (Mol.) Stuntz

Cristian Paz; Jose Becerra; Mario Silva; Viviana Burgos; Bernd Schmidt; Matthias Heydenreich

Article
Rec. Nat. Prod.  (2015)

(-)-Pentylsedinine, a New Alkaloid from the Leaves of Lobelia tupa with Agonist Activity at Nicotinic Acetylcholine Receptor

Paz, C; Becerra, J. ; Silva M.; Burgos, V.; Heydenreich, M; Schmidt, B; Tran, T; Vetter, I

Article ISI SCOPUS
Natural Product Communications  (2015)

A monoclinic form of dendocarbin A: a borderline case of one-dimensional isostructural polymorphism

Paz, C; Burgos, V.; Suarez, S.; Baggio R.

Article ISI SCOPUS
Acta Crystallographica Section C: Structural Chemistry  (2015)

Hobartine: a tetracyclic indole alkaloid extracted from Aristotelia chilensis (maqui)

Paz Robles Cristian ; Badilla Vidal Natalia ; Suarez Sebastian ; Baggio Ricardo

Article
Acta Cryst.  (2014)

INHIBITION OF QUORUM SENSING BY DRIMANE LACTONES FROM CHILEAN FLORA

GERARDO C; Mario Silva; José Becerra; Homero, Urrutia; Katherine Sossa; Cristian Paz

Article ISI SCIELO SCOPUS
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY  (2014)

Two drimane lactones, valdiviolide and 11-epivaldiviolide, in the form of a 1:1 cocrystal obtained from Drimys winteri extracts

Paz Robles Cristian ; Mercado Darı o ; Suarez Sebastian ; Baggio Ricardo

Article
Acta Cryst.  (2014)

(E)-Ethyl 3-(3,4-dihydroxyphenyl)prop-2-enoate: a natural polymorph extracted from Aristotelia chilensis (Maqui)

Paz, C; Moreno Y.; Becerra, J. ; Silva M.; Burgos, V.; Freire, E; Baggio R.

Article ISI SCOPUS
Acta Crystallographica Section C: Crystal Structure Communications  (2013)

A natural polymorph of Ethyl 3-(3,4-dihydroxyphenyl)-2-propenoate

Paz Cristian; Moreno Yanko; Becerra José; Silva Mario; Burgos Viviana; Freire Eleonora; Baggio Ricardo

Article
Acta Cryst  (2013)

A polymorphic form of 4,4-dimethyl-8-methylene-3-azabicyclo[3.3.1]non-2-en-2-yl 3-indolyl ketone, an indole alkaloid extracted from Aristotelia chilensis (maqui)

Paz, C; Becerra, J. ; Silva M.; Freire, E; Baggio R.

Article ISI SCOPUS
Acta Crystallographica Section C: Crystal Structure Communications  (2013)

Drimendiol, A Drimane Sesquiterpene with Quorum Sensing Inhibition Activity

Paz, C; Carcamo, G.; Silva M.; Becerra, J. ; Urrutia, H; Sossa, K

Article ISI SCOPUS
Natural Product Communications  (2013)

Synthesis of the ligand (z)-2-(3-methoxyphenylamino)-4-oxo-4-phenylbut-2- enoic acid and its antifungal activity against the wood stain fungi mucor plumbeus

Paz, C; Cajas-Madriaga D.; Torres C.; Moreno Y.; Fernández M.J.; Becerra J.; Silva M.

Article SCOPUS
Journal of the Chilean Chemical Society  (2013)

SYNTHESIS AND AChE INHIBITING ACTIVITY OF 2, 4 SUBSTITUTED 6-PHENYL PYRIMIDINES

Paz, C; Peter M.G.; Schmidt, B; Becerra, J. ; Gutiérrez M; Astudillo, L; Silva M.

Article ISI SCIELO SCOPUS
Journal of the Chilean Chemical Society  (2012)

6,6,9a-Trimethyl-5,5a,6,7,8,9,9a,9b-octahydronaphtho[1,2-c]furan-1(3H)-one

Brito, I; Lopez-Rodriguez, M; Zarraga, M.; Paz, C; Pérez, C.

Article ISI SCOPUS
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE  (2008)

Regio- and stereoselective Baeyer-Villiger oxidation on (R)-(+)-camphor adducts

Zarraga, M.; Salas, V; Miranda A.; Arroyo, P; Paz, C

Article ISI SCOPUS
TETRAHEDRON-ASYMMETRY  (2008)

Synthesis of a new nitrogenated drimane derivative with antifungal activity

Zarraga, M.; Zarraga, AM; Rodríguez, B.; Pérez, C.; Paz, C; Paz, P; Sanhueza C.

Article ISI SCOPUS
TETRAHEDRON LETTERS  (2008)

X-RAY CRYSTALLOGRAPHIC STRUCTURAL STUDY ON A CINNAMOLIDE-CLASS SESQUITERPENE LACTONE FROM DRIMYS WINTERI FORST. VAR. CHILENSIS

Brito, I; Cardenas, A; Zarraga, M.; Paz, C; Pérez, C.; Lopez-Rodriguez, M

Article ISI
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY  (2008)

BookSection (1)

Drimane sesquiterpenes from Drimys winteri.

Paz, Cristian; Tiezzi, Antonio

BookSection
 (2017)

ConferencePaper (1)

ACTIVIDAD INSECTICIDA DE ARISTOTELIA CHILENSIS SOBRE SITOPHILUS GRANARIUS (COLEOPTERA: CURCULIONIDAE).

Paz, Cristian; Burgos,Viviana; Rebolledo, Ramón

ConferencePaper
 

Patent (3)

Método para combatir plagas de grano almacenado con extractos de Maytenus boaria

Montenegro, Gloria; Zavala, Andrea; Rosales-Villavicencio, Marlene; Rebolledo, Ramón; Paz, Cristian

Patent
 

Sesquiterpenos de drimano con aplicación antifúngica.

Paz, Cristian; Durán, Paola; Viscardi, Sharon

Patent
 

“Extracto etanólico de hojas de Maytenus disticha como conantimicrobiano para el control de Pseudomonas aeruginosa, Staphylococcus aureus y Pseudomonas syringae”

Montenegro, Gloria; Zavala, Andrea; Villalobos Acuna, Blanca; Rosales-Villavicencio, Marlene; Rebolledo, Ramón; Paz, Cristian

Patent Patent pending
 

Proyecto (10)

Indole Alkaloid sub products of Maqui processing as food additives to treatment of Alzheimer’s disease

Paz, Cristian; Paz, Cristian

Proyecto Indole alkaloids purified from leaves of Aristotelia chilensis display neuroprotective effects against Alzheimer models on cell lines
 (2018)

Interdisciplinary network for study of Antarctic fungal bioactive compounds for control of cancer cells, pathogenic yeasts and bacterial strains to human health

Paz, Cristian; Paz, Cristian

Proyecto Antarctic environment, it makes an unique place in the world for study of fungi as producers of bioactive compounds. The increasing health problem occasioned by cancer, bacteria and yeast, which get resistance to classic drugs, there is an urgent need to find new compounds for their treatment
 (2018)

Natural and hemisynthetic drimane sesquiterpenoids, inhibitors of nicotinic acetylcholine receptors. Looking for behavioral modulators.

Paz, Cristian

Proyecto Drimys winteri have drimane sesquiterpenoids which have been shown to be inhibitors of hα4β2 with more selectivity than hα3β4 and hα7 nAChR subtypes. nAChRs may be involved in neurological and mental dysfunctions including drug addictions, depression. We propose the isolation of natural drimanes (mu
 (2018)

Red de colaboración interdisciplinaria para la generación de medicamentos naturales desde la flora nativa Chilena

PCI (REDI170107)

Proyecto
2018-2019
Director(a)

Desarrollo de estrategias de control contra Sitophilus granarius y Tribolium castaneum mediante el uso de compuestos naturales obtenidos de plantas vasculares endémicas

Universidad de La Frontera (DIUFRO DI17-0049)

Proyecto
2017-2019
Director(a)

Red de colaboración interdisciplinaria para la generación de medicamentos naturales desde la flora nativa Chilena

Paz, Cristian

Proyecto Este proyecto une el trabajo interdisciplinario de 9 grupos de investigación nacional y extranjeros con especialidad de química/ biología, para el estudio de compuestos naturales con actividad biológica en busca de nuevos fármacos
 (2017)

“Purificación y determinación estructural de metabolitos secundarios de plantas nativas del valle de Trapa Trapa. Evaluación de potencial antibacteriano contra mastitis bovina”

DIUFRO - Universidad de La Frontera (DI15-0063)

Proyecto
2015-2016
Director(a)

MOLECULAR DETERMINATION OF NATURAL COMPOUNDS FROM NATIVE CHILEAN FLORA.

DAAD (A/13/03310)

Proyecto
2013-2013
Investigador(a)

Síntesis y evaluación funcional de heterociclos derivados de Isoxazoles y Pirazoles 3-carboxamidas, con potencial actividad analgésica. Inhibición de canales de sodio Nav1.8

PFCHA (3130378)

Proyecto
2013-2015
Inv. Responsable

Discovery of novel antimicrobial targeting cell division

Universidad de Concepción

Proyecto
2010-2010
Tesista

44
Cristian Paz

Académico

Ciencias Químicas

Universidad de La Frontera

Temuco, Chile

8
JOSE BECERRA

Professor

Botany Department

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

5
Leandro Ortiz

Académico

Química

Universidad Austral de Chile

Valdivia, Chile

5
Viviana Burgos

Estudiante

Ciencias básicas

Universidad de La Frontera

Temuco, Chile

5
Claudia Perez

Academic

Botany

University of Concepción

Concepción, Chile

4
Mario Silva

Emeritus Professor

Botany Department

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

3
Paola Durán

Profesor Asociado

Producción Agropecuaria

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

2
Ivan Brito

Full Professor

Chemsitry

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

2
Luis Salazar

Profesor Titular

Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

2
Nicolás Saavedra

Profesor Asociado

Departamento de Ciencias Básicas

Universidad de La Frontera

Temuco, Chile

2
Ivan Brito

Profesor Titular

Quimica

Universidad de Antofagasta

Antofagasta, Chile

2
Adrian Paredes

Academico

Química

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

2
Homero Urrutia

Profesor titular

Facultad de Ciencias Biológicas

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Patricio Barra

Profesor Asistente

Scientific and Technological Bioresource Nucleus

Universidad de La Frontera

Temuco, Chile

2
Jaime Cabrera

Assistant Professor

Chemistry

Universidad del Bio Bio

Concepcion, Chile

1
Cristian Balbontin

Investigador

Produccion Vegetal

Instituto de Investigaciones Agropecuarias

Chillán, Chile

1
Jorge Toledo

Director de Departamento

Fisiopatología

Universidad de Concepción

Concepcion, Chile

1
Götz Palfner

Profesor Asociado

Botánica

Universidad de Concepción

Concepción, Chile

1
Paola Méndez

Investigadora

Química

Universidad del Bío-Bío

Concepción, Chile

1
Ignacio Jofré

Postdoctoral Researcher

Departamento de Ciencias Químicas

Universidad de La Frontera

Temuco, Chile

1
IVAN GONZALEZ

Profesor Asistente

Fisiopatología

Universidad De Concepcion

Concepción, Chile

1
María Mora

Full Professor

Ciencias Químicas y Recursos Naturales

Universidad de La Frontera

TEMUCO, Chile

1
Milko Jorquera

PROFESOR TITULAR

CIENCIAS QUIMICA Y RECURSOS NATURALES

UNIVERSIDAD DE LA FRONTERA

TEMUCO, Chile

1
Nery Jara

Profesor Asistente

Departamento de Farmacología

Universidad de Concepción

Concepción, Chile

1
Javiera Gavilán

Estudiante de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

1
Clemente Palacios

Académico

Química y Farmacia

Universidad Arturo Prat

Iquique, Chile

1
Solange Torres

Investigador Postdoctoral

Botánica

Universidad de Concepción

Concepción, Chile

1
CARLOS PEÑA

PROFESOR

INSTITUTO DE CIENCIAS QUIMICAS APLICADAS

Universidad Autónoma de Chile

TEMUCO, Chile

1
Andrea Zavala

1
Sharon Viscardi

Full Professor

Departamento de Procesos, Diagnosticos y evaluación

Universidad Católica de Temuco

Temuco , Chile

1
JORGE FUENTEALBA

Dean

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

1
Katherine Sossa

Associate professor

Centro de Biotecnología

Universidad de Concepción

Concepción, Chile

1
Andres Opazo

Profesor Asistente

Microbiología

Universidad de Concepción

Concepción, Chile

1
margarita gutierrez

Proffesor

UNIVERSIDAD DE TALCA

Talca, Chile

1
Christian Nuñez

Director Departamento de Química

Química

Universidad del Bío Bío

Concepción, Chile

1
Veronica Jimenez

Assistant Professor

Chemistry

Universidad Andres Bello

Talcahuano, Chile