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Manuel Marcelo Alvarez Lobos

Gastroenterologist and Chief of Institute of Medicine

Pontificia Universidad Católica de Chile

Santiago, Chile

Inflamatory bowel disease (Crohn's disease and ulcerative colitis); clinical and basic research. Infectious gastrointestinal diseases (Enterocolitis due to Clostridium difficille and Salmonella), clinical and basic research.

Medico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1994
Internal Medicine Residence (specialist), PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997
Gastroenterology fellowship (Specialist), PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009

Associated Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Santiago, Chile

1997 - A la fecha

Chief of Institute of Medicine Other

Hosital Clínico UC/Red Salud UC-Christus

Santiago, Chile

1999 - A la fecha

- Professor (tutor) of the doctoral student in medicine, 2013 to present: Maria Jose Parga, Faculty of Medicine, Pontificia Universidad Católica de Chile.
- Seminar for the students of the doctoral in medical sciences, 2013-to present : Interaction pathogen and intestine. Course MDO 1220 "The cellular interactions in the Disease: Mechanisms and functions". Phd in Medical Sciences.
- Member of the commission in the thesis of the Magister in Medical Sciences in immunology, 2009-2011: Enzo Candia: " characterization of variants of TLR2 produced by intestinal mononuclear cells of patients with inflammatory bowel diseases". Faculty of Medicine. University of Chile.
- Member of the commission of the thesis for a doctoral degree in Biomedical Sciences, 2011-2014: Ms. Marjorie Source Lopez, "E Coli adherent invasive contributes to the chronic inflammation in the E of Crohn's Disease ". Faculty of Medicine, University of Chile.
- Tutor of the research project of the student of medicine Francisco Diaz 2013-2014: temporal evolution of the spores of the Clostridium difficile. Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile.
- Tutor of the research project of Fellow in Gastroenterology Dr. Juan P Ortega (2013-2014): "Effect of vitamin D levels in regulatory T LYMPHOCYTES in peripheral blood IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE". Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile.
- Tutor of the research project of Fellow in Gastroenterology Dr. Carlos Aguero L (Center for medical research: PG-06/13; 2013-2014): "Ribotyping clinical and environmental of Clostridium difficile in a university hospital and its relationship with the nosocomial diarrhea”. Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile.
- Tutor of the Research Project of the student of Medicine Mr. Joaquín Ananías, 2013: "Study of the effect of latitude on the prevalence of Inflammatory Bowel Diseases in Chile. Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile.
- Tutor of the Research Project of the student of Medicine Mr. Sr. Juan Carlos Alvarado P, 2013."Clinical and microbiological characterization of the nosocomial diarrhea associated with Clostridium difficile in adult patients of the Clinical Hospital of the Catholic University". Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile.
- Tutor of the Research Project of the student of Medicine Mr. Juan Carlos Alvarado P, Center for medical research: Summer of 2012:"Smoking as a risk factor for enteric infections by Salmonella". Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile.
- Co-Director of the thesis of the Magister of Nutrition of Maria Catalina Catherine Heusser, 2012-2013: Evaluation of the protein ligand intestinal fatty acid and plasma citrulline as biomarkers of enteral function and nutritional status in patients with intestinal diseases. Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile.
- Tutor of the research project of Fellow in Gastroenterology Dr. Cristián Hernandez R (Center for medical research: PG-20/11; 2011-2012): "Mechanisms of pathogenicity of Clostridium difficile and their clinical implications”. Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile.
- Tutor of the research project of Fellow in Gastroenterology Dr. Alberto espino (2007-2008): "Effect of genotype 4G/ 4G in the intestinal and hepatic fibrosis associated with obesity”. Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile.
- Tutor of the research project of Fellow in Gastroenterology Dr. Andrés Jorquera (2005-2006): "Phenotypic and genotypic characterization of the TPMT in chilean population”. Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile.

Dr. Gabriel Letelier Award

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 1993

"Dr Gabriel Letelier" Award, to the best graduate in Internal Medicine year 1993, School of Medicine, Pontificia Universidad Católica de Chile
Chief of residents in Internal Medicine

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, 1996

Chief of residents, Internal Medicine, School of Medicine, Pontificia Universidad Católica de Chile.
"Dr Ivan Marinovic" Award

SOCIEDAD CHILENA DE GASTROENTEROLOGIA

Chile, 1998

"Dr Ivan Marinovic" Award, to the best research of gastroenterology fellows in the XXV Chilean Congress of Gastroenterology, year 1998: "Diagnosis of Clostridium difficile infection". Chilean Society of Gastroenterology.
poster of distinction

american gastroenterology association

Estados Unidos, 2001

"Poster of Distinction" Award, to the 10% of the best poster in the Digestive Disease Week, Atlanta, USA :for the research: "High frequency of cholestatic variant in chilean patient with autoimmune hepatitis", American Gastroenterology Association.
Dr Jaime Chesta Award

SOCIEDAD CHILENA DE GASTROENTEROLOGIA

Chile, 2006

"Dr Jaime Chesta" Award, to the young investigator, Chilean gastroenterological Association, XXXIII Chilean Congress of Gastroenterology
Clinical Excellence Junior 2010 Award

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

Clinical Excellence Junior 2010 Award, in recognition of his outstanding work in the area of Clinical Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile.
"Emilio Saval 2012" Award

SOCIEDAD CHILENA DE GASTROENTEROLOGIA

Chile, 2012

"Emilio Saval 2012" Award to the best research work published in the Journal "Gastroenterología Latinoamericana" yaer 2011 for the following research: Manuel Álvarez-Lobos, Juan I. Arostegui, Miquel Sans, Dolors Tassies, Susana Plaza, Joan C. Reverter, Josep M Piqué, Jordi Yagüe, and Julián Panés. La mutación R92Q del gen TNFRSF1A está asociado con manifestaciones extraintestinales en la enfermedad de Crohn. Gastroenterología Latinoamericana, 2011; 22(3):232-237.


Do Patients Older Than 60 Years With Inflammatory Bowel Disease Have More Vertebral Fractures Than Age-matched Controls? A Study Using Abdominal and Pelvic CT Scans With Sagittal Reformatting as Screening Tool Besa P.; Meissner-Haecker A.; Ledermann G.; Perez-Valenzuela J.; Vergara-Lopez M.; Alvarez-Lobos M.; Urrutia J. Article ISI SCOPUS JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS (2020)
Symptom profiles and risk factors for hospitalization in patients with SARS-CoV-2 and COVID-19: A Large Cohort from South America Díaz, Luis Antonio; García-Salum, Tamara; Fuentes-López, Eduardo; Ferrés, Marcela; Medina, Rafael A; Riquelme, Arnoldo.; Levican, Jorge; Almonacid, Leonardo, I; Serrano, Eileen; Chahuan, Javier; Cofré, Colomba; Álvarez, Manuel; Labarca, Jaime; Valderrama, Sebastián; Salinas, Erick; Toro, Adriana; Ortega, Marcos; García, Patricia; Pizarro, Margarita. Article ISI Gastroenterology (2020)
The Cell Circuitry of Ulcerative Colitis, a New View for a Highly Complex Disease Perez-Jeldres, Tamara; Alvarez-Lobos, Manuel; Rivera Nieves, Jesus; Villablanca, Eduardo J. Article ISI Gastroenterology (2020)
Mucosal Exposure to Cigarette Components Induces Intestinal Inflammation and Alters Antimicrobial Response in Mice Berkowitz L.; Pardo-Roa C.; Salazar G.A.; Salazar-Echegarai F.; Miranda, J. P.; Ramírez G.; Chávez J.L.; Kalergis A.M.; Bueno, S. M.; Álvarez-Lobos M. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
The absence of interleukin 10 affects the morphology, differentiation, granule content and the production of cryptidin-4 in Paneth cells in mice Berkowitz, Loni; Pardo-Roa, Catalina; Ramírez, Gigliola; Vallejos, Omar P.; Sebastián, Valentina P.; Riedel, Claudia A; Álvarez-Lobos, Manuel; Bueno, Susan M.; Chamaillard, Mathias Article ISI SCOPUS PLOS ONE (2019)
Etiologic and clinical characterization of community acquired gastroenteritis in adult patients in a Chilean emergency room by the FilmArray GI panel Valenzuela, Carlos; Legarraga, Paulette; Pena, Arturo; Arenas, Alex; Berkowitz, Loni; Ramirez, Gigliola; Wozniak, Aniela; Garcia, Patricia; Alvarez-Lobos, Manuel Article PLOS ONE (2018)
Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation=> Opposing Effects in Crohn’s Disease and Ulcerative Colitis Loni Berkowitz, Bárbara M. Schultz; Geraldyne A. Salazar, Catalina Pardo-Roa; Valentina P. Sebastián, Manuel M. Álvarez-Lobos Article FRONTIERS IN IMMUNOLOGY (2018)
Outcome of surgery for Crohns colitis. Review of 28 cases Felipe Imigo G., María-Elena Molina P.; Manuel Álvarez-Lobos, Carlos Quintana V.; Julieta Klaassen L., Javiera Torres M.; Ignacio Duarte G., Felipe Bellolio R. Article REVISTA MEDICA DE CHILE (2018)
Persistent Salmonella enterica serovar Typhimurium infection increases the susceptibility of Mice to Develop intestinal inflammation Schultz, BM; Salazar, GA; Paduro, CA; Pardo-Roa, C; Pizarro, DP; Salazar-Echegarai, FJ; Torres, J; Riedel, CA; Kalergis, AM; Alvarez-Lobos, MM; Bueno, SM Article Frontiers in Immunology (2018)
Practical clues for a fecal microbiota transplantation by colonoscopy for recurrent Clostridium difficile infection. Experience in a University center Cruz, R; Monrroy, H.; Flandez, J; Perez, CM; Alvarez-Lobos, M; Hernandez-Rocha, C Article REVISTA CHILENA DE INFECTOLOGIA (2018)
A Potential Role of Salmonella Infection in the Onset of Inflammatory Bowel Diseases. Schultz BM, Paduro CA; Salazar GA, Salazar-Echegarai FJ; Sebastián VP, Riedel CA; Kalergis AM, Alvarez-Lobos M Article Frontiers in Immunology (2017)
Characterization of Chicken IgY Specific to Clostridium difficile R20291 Spores and the Effect of Oral Administration in Mouse Models of Initiation and Recurrent Disease Pizarro-Guajardo M., Díaz-González F.; Álvarez-Lobos M., Paredes-Sabja D. Article FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)
Interleukin-10 Production by T and B Cells Is a Key Factor to Promote Systemic Salmomnella enterica Serovar Typhimurium Infection in Mice Salazar, Geraldyne A.; Peñaloza, Hernán F.; Pardo-Roa, Catalina; Schultz, Bárbara M.; Muñoz-Durango, Natalia; Gómez, Roberto S.; Salazar, Francisco J.; Pizarro, Daniela P.; Riedel, Claudia A.; González, Pablo A.; Alvarez-Lobos, Manuel; Kalergis, Alexis M.; Bueno, Susan M. Article Frontiers in Immunology (2017)
Management of severe ulcerative colitis An up-to-date Hernandez-Rocha, C; Ibanez, P; Molina, ME; Klaassen, J; Valenzuela, A; Candia, R; Bellolio, F; Zuniga, A; Miguieles, R; Miquel, JF; Chianale, J; Alvarez-Lobos, M Article REVISTA MEDICA DE CHILE (2017)
Solar radiation is inversely associated with inflammatory bowel disease admissions Jaime, Francisca; Riutort, Maria C.; Alvarez-Lobos, Manuel; Hoyos-Bachiloglu, Rodrigo; Camargo Jr, Carlos A.; Borzutzky, Arturo Article SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2017)
Chilean consensus of prevention, diagnosis and treatment of Clostridium difficile-associated diarrhea Hernandez-Rocha, C; Pidal, P; Ajenjo, MC; Quera, R; Quintanilla, M; Lubascher, J; Jemenao, MI; Ibáñez P.; Alvarez-Lobos, M; Diomedi A.; Marcotti, A; Acuña M.; Arab, JP; Riquelme A.; candia, r; Carvajal S. Article ISI REVISTA CHILENA DE INFECTOLOGIA (2016)
Consenso chileno de prevención, diagnóstico y tratamiento de la diarrea asociada a Clostridium difficile Cristian Hernández-Rocha, Paola Pidal; M. Cristina Ajenjo, Rodrigo Quera; Marcela Quintanilla, Jaime Lubascher; M. Irene Jemenao, Patricio Ibáñez; Manuel Álvarez-Lobos, Alexis Diomedi; Alejandra Marcotti, Mirta Acuña; Juan P Arab, Arnoldo Riquelme; Roberto Candía, Sergio Carvajal Article REVISTA CHILENA DE INFECTOLOGIA (2016)
Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance Riquelme, Sebastián A.; Carreño, Leandro J.; Espinoza, Janyra A.; Mackern-Oberti, Juan Pablo; Alvarez-Lobos, Manuel M.; Riedel, Claudia A.; Bueno, Susan M.; Kalergis, Alexis M. Article IMMUNOLOGY (2016)
Opposing roles of IL-10 in acute bacterial infection Peñaloza, Hernán F.; Schultz, Barbara M.; Nieto, Pamela A.; Salazar, Geraldyne A.; Suazo, Isidora; Gonzalez, Pablo A.; Riedel, Claudia A.; Alvarez-Lobos, Manuel M.; Kalergis, Alexis M.; Bueno, Susan M. Article Cytokine and Growth Factor Reviews (2016)
Predominance of Clostridium difficile ribotypes 012, 027 and 046 in a university hospital in Chile, 2012 Plaza-Garrido, A; Barra-Carrasco, J; Macias, JH; Carman, R; Fawley, WN; Wilcox, MH; Hernandez-Rocha, C; Guzman-Duran, AM; Alvarez-Lobos, M; Paredes Sabja D Article ISI SCOPUS EPIDEMIOLOGY AND INFECTION (2016)
Interleukin-10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae Peñaloza HF; Nieto, PA; Munoz-Durango, N; Salazar-Echegarai, FJ; Torres J.; Parga, MJ; Alvarez-Lobos, M; Riedel, CA; Kalergis, AM; Bueno, SM Article ISI SCOPUS Immunology (2015)
Outcome of relapsing Clostridium difficile infections do not correlate with virulence-, spore- and vegetative cell-associated phenotypes Plaza-Garrido, A; Miranda-Cardenas, C; Castro-Cordova, P; Olguin-Araneda, V; Cofre-Araneda, G; Hernandez-Rocha, C; Carman, R; Ibáñez P.; Fawley, WN; Wilcox, MH; Gil, F; Calderon, IL; Fuentes, JA.; Guzman-Duran, AM; Alvarez-Lobos, M; Paredes Sabja D Article ISI SCOPUS Anaerobe (2015)
Achieving the best bowel preparation for colonoscopy Parra-Blanco, A; Ruiz A.; Alvarez-Lobos, M; Amoros A.; Gana J.C.; Ibáñez P.; Ono A.; Fujii T. Article ISI SCOPUS WORLD JOURNAL OF GASTROENTEROLOGY (2014)
Clostridium difficile spores and its relevance in the persistence and transmission of the infection Barra-Carrasco, J; Hernandez-Rocha, C; Ibáñez P.; Guzman-Duran, AM; Alvarez-Lobos, M; Paredes Sabja D Article ISI REVISTA CHILENA DE INFECTOLOGIA (2014)
Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome De La Fuente M.; Franchi, L; Araya D.; Diaz-Jimenez, D; Olivares M.; Alvarez-Lobos, M; Golenbock, D; Gonzalez, MJ; Lopez-Kostner, F; Quera, R; Nuñez G.; Vidal, R; Hermoso, MA Article ISI SCOPUS INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2014)
Performance of prognostic index in severe Clostridium difficile-associated infection. Retrospective analysis in a university hospital Hernandez-Rocha, C; Sufan, RT; Plaza-Garrido, A; Barra-Carrasco, J; Luengo, CA; Levy, GI; Lazo, PI; Guzman-Duran, AM; Paredes Sabja D; Pezoa, MEM; Alvarez-Lobos, M Article ISI REVISTA CHILENA DE INFECTOLOGIA (2014)
Atypical presentation of pseudomembranous colitis localized in adenomatous polyps Hernandez-Rocha, C; Barra-Carrasco, J; guzman AM; Paredes Sabja D; Lezcano, G; Zoroquiain, P; Alvarez-Lobos, M Article ISI SCOPUS World Journal of Gastroenterology (2013)
Prospective comparison of a commercial multiplex real-time polymerase chain reaction and an enzyme immunoassay with toxigenic culture in the diagnosis of Clostridium difficile-associated infections Hernandez-Rocha, C; Barra-Carrasco, J; Alvarez-Lobos, M; Paredes Sabja D; Guzman-Duran, AM Article ISI DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2013)
Role of Salmonella enterica exposure in Chilean Crohn's disease patients Alvarez-Lobos, M; Pizarro, DP; Palavecino, CE; Espinoza, A.; Sebastian, VP; Alvarado, JC; Ibáñez P.; Quintana, C.; Díaz O.; Kalergis, AM; Bueno, SM Article ISI SCOPUS World Journal of Gastroenterology (2013)
Clinical and genetic features of hereditary periodic fever syndromes in Hispanic patients: the Chilean experience Vergara C.; Borzutzky, A; Gutiérrez M.A.; Iacobelli, S; Talesnik E.; Martinez M.E.; Stange, L; Basualdo, J; Maluje, V; Jimenez, R; Wiener, R; Tinoco, J; Jarpa E.; Arostegui J.I.; Yague, J; Alvarez-Lobos, M Article ISI SCOPUS Clinical Rheumatology (2012)
Clostridium difficile associated infections: an updated view Hernandez-Rocha, C; Naour, S; Alvarez-Lobos, M; Paredes Sabja D Article ISI REVISTA CHILENA DE INFECTOLOGIA (2012)
Genotipo y fenotipo de la enzima tiopurina metiltransferasa en población chilena Jorquera, A.; Solari, S; Vollrath, V; Guerra, I.; Chianale, J; Cofré C; Kalergis, A; Ibáñez P.; Bueno, S; Alvarez-Lobos, M Article SCIELO SCOPUS REVISTA MEDICA DE CHILE (2012)
Increased production of soluble TLR2 by lamina propria mononuclear cells from ulcerative colitis patients Candia, E.; Diaz-Jimenez, D; Langjahr P.; Nunez L.E.; De La Fuente M.; Farfan, N; Lopez-Kostner, F; Abedrapo M.; Alvarez-Lobos, M; Pinedo, G; Beltrán C.J.; González C; Gonzalez M.-J.; Quera, R; Hermoso M.A. Article ISI SCOPUS IMMUNOBIOLOGY (2012)
Phenotype and genotype of thiopurine methyltransferase in Chilean individuals Jorquera, A.; Solari, S; Vollrath, V; Guerra, I.; Chianale, J; Cofré C; Kalergis, A; Ibáñez P.; Bueno, S; Alvarez-Lobos, M Article ISI REVISTA MEDICA DE CHILE (2012)
Plasminogen activator inhibitor type 1 serum levels and 4G/5G gene polymorphism in morbidly obese Hispanic patients with non-alcoholic fatty liver disease Espino A.; Villagrán A.; Vollrath, V; Hanckes P.; Salas, R.; Farah, A; Solís N.; Pizarro M.; Escalona A.; Boza, C; Perez G.; Carrasco, G; Padilla, O; Miguel, JF; Nervi, F; Chavez-Tapia, NC; Arab, JP; Alvarez-Lobos, M; Arrese M.; Riquelme A. Article ISI SCOPUS Annals of Hepatology (2011)
Soluble ST2: A new and promising activity marker in ulcerative colitis Diaz-Jimenez, D; nunez, le; Beltran, CJ; Candia, E.; Suazo, C; Alvarez-Lobos, M; Gonzalez, MJ; Hermoso, MA; Quera, R Article ISI SCOPUS World Journal of Gastroenterology (2011)
Non-alcoholic fatty liver disease and its association with obesity, insulin resistance and increased serum levels of C-reactive protein in Hispanics Riquelme A.; Arrese M.; Soza A.; Morales A.; Baudrand R.; Perez-Ayuso, RM; González R.; Alvarez M.; Hernández, V.; Garcia-Zattera, MJ; Otarola, F.; Medina, B.; Rigotti, A.; Miquel, JF; Marshall G.; Nervi, F Article ISI SCOPUS LIVER INTERNATIONAL (2009)
Pulmonary and gastric sarcoidosis. Report of one case Hernández J.; Gonzalez S.; Alvarez M.; Lisboa C. Article ISI REVISTA MEDICA DE CHILE (2009)
Combined type-1 plasminogen activator inhibitor and NOD2/CARD15 genotyping predicts complicated Crohn's disease behaviour Alvarez-Lobos, M; Arostegui, JI; Sans, M; Tassies, D; Piu, J; Reverter, JC; Pique, JM; Yague, J; Panes, J Article ISI SCOPUS ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2007)
Gallbladder disease is associated with insulin resistance in a high risk Hispanic population Nervi, F; Miquel, JF; Alvarez M.; Ferreccio C.; Garcia-Zattera, MJ; González R.; Perez-Ayuso, RM; Rigotti, A.; Villarroel L. Article ISI SCOPUS JOURNAL OF HEPATOLOGY (2006)
Tumor necrosis factor receptor associated periodic syndrome (TRAPS). Report of two cases Alvarez-Lobos, M; Hunter B.; Cofré C; Benítez C.; Talesnik E.; Oyarzo M.; Arostegui, JI; Yague, J Article ISI REVISTA MEDICA DE CHILE (2006)
Tumor necrosis factor receptor associated periodic syndrome (TRAPS). Report of two cases TRAPS, un síndrome autoinflamatorio. Casos cínicos Alvarez-Lobos, M; Benítez C.; Hunter B.; Cofré C; Talesnik E.; Oyarzo M.; Arostegui J.I.; Yague, J Article REVISTA MEDICA DE CHILE (2006)
Capsule endoscopy and inflammatory bowel disease Cápsula endoscópica y enfermedad inflamatoria intestinal Alvarez-Lobos, M Article GASTROENTEROLOGIA Y HEPATOLOGIA (2005)
Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence Alvarez-Lobos, M; Arostegui, JI; Sans, M; Tassies, D; Plaza, S; Delgado, S; Lacy, AM; Pique, JM; Yague, J; Panes, J Article ISI SCOPUS ANNALS OF SURGERY (2005)
Down-regulation of endothelial adhesion molecules and leukocyte adhesion by treatment with superoxide dismutase is beneficial in chronic immune experimental colitis Segui, J; Gil, F; Gironella, M; Alvarez M.; Gimeno, M; Coronel, P; Closa, D; Pique, JM; Panes, J Article ISI SCOPUS INFLAMMATORY BOWEL DISEASES (2005)
ENFERMEDAD INJERTO VERSUS HUESPED: MANIFESTACION-ENTEROCOLICA Y DIAGNOSTICO DIFERENCIAL Ortega M, Claudia; O'Brien, Andrés; BERRÍOS G, CLAUDIO; Álvarez, Manuel; Salazar S, Iván Article REVISTA CHILENA DE RADIOLOGIA (2005)
Incidence and prevalence of hepatitis C virus infection in Chile. González R.; Soza A.; Hernández, V.; Perez R.M.; Alvarez M.; Morales A.; Arellano M.; Riquelme A.; Viviani, P; Covarrubias, C; Arrese M.; Miquel, J.F; Nervi, F Article SCOPUS ANNALS OF HEPATOLOGY (2005)
Increased orocecal transit time in patients with nonalcoholic fatty liver disease Soza A.; Riquelme A.; González R.; Alvarez M.; Perez-Ayuso, RM; Glasinovic, JC; Arrese M. Article ISI SCOPUS DIGESTIVE DISEASES AND SCIENCES (2005)
Clinical and epidemiological features of 147 Chilean patients with chronic hepatitis C. Soza A.; Arrese M.; González R.; Alvarez M.; Perez R.M.; Cortes P.; Patillo, A; Riquelme A. Article ANNALS OF HEPATOLOGY (2004)
Natural history of cholelithiasis and incidence of cholecystectorny in an urban and a Mapuche rural area Perez-Ayuso, RM; Hernández, V.; Gonzalez, B.; Carvacho C.; Navarrete C.; Alvarez M.; González R.; Marshall G.; Miquel, JF; Nervi, F Article ISI REVISTA MEDICA DE CHILE (2002)
Diagnóstico de diarrea por Clostridium difficile: En busca de un enfoque clínico más eficiente. Alvarez-Lobos, M; Gonzalez, R.; Briceño, I.; Cofre, C.; Labarca, J.; Vial, P.; García, P. Article Revista Médica de Chile (2001)
Use of methylene blue in patients with refractory septic shock: Impact on hemodynamics and gas exchange Andresen M.; Dougnac, A; Díaz O.; Hernández G.; Castillo L.; Bugedo G.; Alvarez M.; Dagnino J. Article JOURNAL OF CRITICAL CARE (1998)


Complications of Gastrointestinal Endoscopy in 85,391 Procedures Espino A.; García X.; Mac-Namara, M; Richter, H; Pimentel, F; Biel, F; Robles C.; Callejas M; Sharp, AC; Donoso, A.; candia, r; Gonzalez, RG; Jarufe, N; Arrese M.; Alvarez-Lobos, M; Padilla, O Abstract GASTROINTESTINAL ENDOSCOPY (2012)
Clinical and Genetic Features of Autoinflammatory Syndromes in Hispanic Patients: The Chilean Experience Vergara C.; Borzutzky, A; Gutierrez MA; Iacobelli, S; Talesnik E.; Martinez, Me; Stange, L; Basualdo, J; Maluje, V; Jimenez, R; Jarpa E.; Wiener, R; Tinoco, J; Arostegui, JI; Yague, J; Alvarez-Lobos, M Abstract ARTHRITIS AND RHEUMATISM (2011)
CLINICAL CHARACTERISTICS OF A GROUP OF PATIENTS WITH AUTOINFLAMMATORY SYNDROMES Vergara C.; Jacobelli, S.; Gutiérrez M; Talesnik E.; Martínez M; Stange, L; Basualdo, J; Maluje, V; Jimenez, R; Arostegui, J; Yague, J; Alvarez M. Abstract JCR-JOURNAL OF CLINICAL RHEUMATOLOGY (2010)
REFRACTORY TRAPS SYNDROME SUCCESSFUL TREATMENT WITH ABATACEPT Baccigaluppi, G; Alvarez M.; Gutiérrez M; Iacobelli, S Abstract JCR-JOURNAL OF CLINICAL RHEUMATOLOGY (2010)
Genotype and phenotype of thiopurine methyl transferase (TPMT) in Chilean population Solari, S; Jorquera, A.; Selman, C.; Guerra, I.; Alvarez M. Abstract THERAPEUTIC DRUG MONITORING (2007)
High-sensitivity C-reactive protein, a new marker for non alcoholic fatty liver disease: A population-based study. Riquelme A.; Baudrand R.; Morales A.; Pérez RM; Alvarez M.; González R.; Hernández, V.; Soza A.; Arrese M.; Otarola, F.; Medina, B.; Garcia, MJ; Marshall G.; Miquel, JF; Nervi, F Abstract HEPATOLOGY (2004)
Characterization of small hepatocellular carcinoma with contrast-enhanced ultrasonography: Preliminary results. Gonzalez G. ; Arrese M.; Martinez, J.; Alvarez M.; Soza A.; Guzman, S; Perez-Ayuso, R Abstract HEPATOLOGY (2001)


TRAPS, un síndrome autoinflamatorio: Casos cínicos Álvarez-Lobos, Manuel; Hunter, Bessie; Cofré, Colomba; Benítez, Carlos; Talesnik, Eduardo; Oyarzo, Mauricio; Aróstegui, Juan I; Yagüe, Jordi CaseReport SCIELO REVISTA MEDICA DE CHILE (2006)


Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome (vol 304, pg 384, 2014) De La Fuente M.; Franchi, L; Araya D.; Diaz-Jimenez, D; Olivares M.; Alvarez-Lobos, M; Golenbock, D; Gonzalez, MJ; Lopez-Kostner, F; Quera, R; Nuñez G.; Vidal, R; Hermoso, MA Errata ISI SCOPUS International Journal of Medical Microbiology (2015)


Diagnostic accuracy of a multiplex real-time PCR to predict Clostridium difficile ribotype 027 Barra-Carrasco, J; Hernandez-Rocha, C; Miranda-Cardenas, C; Alvarez-Lobos, M; Duran, AMG; Paredes Sabja D Letter ISI SCOPUS Anaerobe (2013)
Epidemic Clostridium difficile Ribotype 027 in Chile Hernandez-Rocha, C; Barra-Carrasco, J; Pizarro-Guajardo, M; Ibáñez P.; Bueno, S. M.; Sarker M.R.; Guzmán A.M.; Alvarez-Lobos, M; Paredes Sabja D Letter ISI SCOPUS Emerging Infectious Diseases (2012)
Gastrointestinal manifestations among Chilean patients infected with novel influenza A (H1N1) 2009 virus Riquelme A.; Alvarez-Lobos, M; Pavez, C.; Hasbún P.; Dabanch, J; Cofré C; Jimenez, J; Calvo M. Letter ISI SCOPUS Gut (2009)


"Estudio del efecto de la latitud sobre la prevalencia de las enfermedades Inflamatorias Intestinales en Chile. Centro de Investigaciones Médicas, Facultad de Medicina, P U Católica de Chile (Proyecto Ayudante Alumno. J Ananías. 2013.) Proyecto 2013-2014 Inv. Patrocinante
=> "Caracterización clínica y microbiológica de las diarreas intrahospitalarias asociadas a Clostridium difficile en pacientes adultos del Hospital Clínico de la Universidad Católica". Centro de Investigaciones Médicas, Facultad de Medicina, P U Católica de Chile (Proyecto Ayudante-Alumno. Juan C. Alvarado. 2013.) Proyecto 2013-2013 Inv. Patrocinante
Estructuración de un protocolo clínico de enfrentamiento de las diarreas intrahospitalarias, de acuerdo a la epidemiología local del Clostridium difficile y el perfil clínico de la infección, en dos centros hospitalarios. FONIS (Sa12i2197) Proyecto 2013-2015 Inv. Principal
Ribotipificación Clínica y ambiental del Clostridium difficile en un hospital Universitario y su relación con las diarreas intrahospitalarias”. Centro de Investigaciones Médicas, Facultad de Medicina, P U Católica de Chile (Proyecto de Becado CIM-UC.(PG 06/13)) Proyecto 2013-2014 Inv. Patrocinante
ROLE OF HEME OXYGENASE-1 IN ACUTE AND CHRONIC INTESTINAL INFLAMATION=> INFECTIOUS AND IMMUNE MODELS. FONDECYT (1131012) Proyecto 2013-2017 Inv. Responsable
“EFECTO DE LOS NIVELES DE VITAMINA D EN LINFOCITOS T REGULADORES EN SANGRE PERIFÉRICA EN PACIENTES CON ENFERMEDAD INFLAMATORIA INTESTINAL”. Centro de Investigaciones Médicas, Facultad de Medicina, P U Católica de Chile (Proyecto de Becado CIM-UC.(PG-07/13)) Proyecto 2013-2014 Inv. Patrocinante
CELLULAR AND MOLECULAR MECHANISMS RELEVANT IN THE INTERACTION OF CLINICAL ISOLATES OF ADHERENT INVASIVE ESCHERICHIA COLI (AIEC) WITH EPITHELIAL CELLS OR MACROPHAGES IN CROHN S DISEASE FONDECYT (1120577) Proyecto 2012-2016 Coinvestigador(a)
Tabaco como factor de riesgo para infecciones entéricas por Salmonella. Centro de Investigaciones Médicas, Facultad de Medicina, P U Católica de Chile (Proyecto Inmersión en Investigación. Verano 2012) Proyecto 2012-2012 Inv. Patrocinante
Mecanismos de patogenicidad del Clostridium Difficile y sus implicancias clínicas. Centro de Investigaciones Médicas, Facultad de Medicina, P U Católica de Chile (CIM-UC=> (PG-20/11). Proyecto de Becado) Proyecto 2011-2012 Inv. Patrocinante
ROLE OF ST2/IL-33 SYSTEM IN MUCOSAL INFLAMMATION AND INFLAMMATORY BOWEL DISEASES PATHOGENIA FONDECYT (1110381) Proyecto 2011-2015 Coinvestigador(a)
EVALUATION OF SALMONELLA ENTERICA CAPACITY TO PROMOTE INFLAMMATORY BOWEL DISEASE IN SUSCEPTIBLE HOST FONDECYT (1100971) Proyecto 2010-2013 Inv. Responsable
ALTERACIONES DEL METABOLISMO HEPATICO DEL COLESTEROL Y ACIDOS BILIARES EN LA PATOGENIA DE LA COLETIASIS. FONDECYT (1070891) Proyecto 2007-2010 Coinvestigador(a)
PATOLOGIA MOLECULAR DE LA FORMACION DE CALCULOS VESICULARES DE COLESTEROL Y ROL DE LA PROTEINA SCP-2 EN EL TRANSPORTE Y SECRECION HEPATICA DE COLESTEROL. FONDECYT (1971092) Proyecto 1997-2000 Coinvestigador(a)


Heme Oxygenase-1 as a Modulator of Intestinal Inflammation Development and Progression Sebastian, VP; Salazar, GA; Coronado-Arrazola, I; Schultz, BM; Vallejos, OP; Berkowitz L.; Alvarez-Lobos, MM; Riedel, CA; Kalergis, AM; Bueno, SM Review ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
Infecciones causadas por Clostridium difficile: una visión actualizada Hernandez-Rocha, C; Alvarez-Lobos, M; Naour, S; Paredes Sabja D Review SCIELO SCOPUS REVISTA CHILENA DE INFECTOLOGIA (2012)
Active and refractory ulcerative proctitis: An update Caselli, G; Pinedo, G; Zuniga, A; Alvarez M. Review REVISTA MEDICA DE CHILE (2010)

Manuel Alvarez

Gastroenterologist and Chief of Institute of Medicine

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

Daniel Paredes

Associate Professor

Department of Biological Sciences

Universidad Andrés Bello

Santiago, Chile

MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

Rodrigo Quera

Gastroenterólogo

Gastroenterología

CLÍNICA LAS CONDES, SERVICIO DE GASTROENTEROLOGÍA

Santiago, Chile

Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE - ESCUELA DE MEDICINA - DEPTO DE GASTROENTEROLOGÍA

Santiago, Chile

Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

David Diaz

Asistente de Investigación

Instituto de Ciencias Biomédicas, Facultad de Medicina

Universidad de Chile

Santiago, Chile

Maria González

Academico

FACULTAD DE MEDICINA - UNIVERSIDAD DE CHILE

Santiago, Chile

Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

ANDRES JORQUERA

GASTROENTEROLOGO

CONSULTORIO EXTERNO

HOSPITAL DE CURANILHUE

CURANILAHUE, Chile

Attilio Rigotti

Full Professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

Marjorie De la Fuente

Académico investigador

Escuela de Medicina

Universidad Finis Terrae

Santiago , Chile

Patricio Ibañez

Asistant professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA

Santiago, Chile

Loni Berkowitz

Investigador postdoctoral

Nutrición, diabetes y metabolismo

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

Sebastián Naour

Gestor Operacional de Transferencia Tecnológica

Vicerrectoría de Transferencia Tecnológica y Extensión

Universidad Tecnológica Metropolitana

Santiago, Chile

Lucia Nuñez

ENCARGADA DE VALORACION

FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Catalina Pardo

Profesor Asistente

Dpto. de Salud del Niño y Adolescente

Pontificia Universidad Católica de Chile

Region Metropolitana, Chile

Cristian Hernández

Assistant Professor

Gastroenterology

Pontificia Universidad Católica de Chile

Santiago, Chile

Juan Arab

Assistant Professor

Gastroenterologia

Pontificia Universidad Católica de Chile

Santiago, Chile

Maria Jose Garcia

Profesor Asistente Adjunto

Estadistica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Sandra Solari

Profesor Clinico Asociado

Laboratorios Clinicos

Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Caroll Beltrán

Profesor Asistente, Investigador Principal

Medicina

Universidad de Chile, Fac Medicina

SANTIAGO, Chile

Angela Plaza

Postodoctorado

Ingeniería Civile en Obras Civil

Universidad de Santiago de Chile

Estación Central, Chile

Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

roberto vidal

Head of Pathogenic Escherichia coli Laboratory

Director Microbiology and Mycology Program

UNIVERSIDAD DE CHILE

Santiago, Chile

Roberto Candia

Profesor Asistente

Gastroenterologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

Omar Vallejos

Lab Manager y Coordinador

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

JOSE MIRANDA

Estudiante de Doctorado

Nutrición, Diabetes y Metabolismo

Pontificia Universidad Católica de Chile

Santiago, Chile

Guillermo Bugedo

Staff Medicina Intensiva

Medicina Intensiva

Pontifica Universidad Catolica de Chile

Santiago, Chile

Marjorie Pizarro

Asistente de Investigacion

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Max Andresen

profesor asociado categoria ordinaria

medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Francisco Salazar

Profesional Asistente

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

Fernando Gil

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Juan Fuentes

Académico

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

Paola Viviani

Profesor Asistente, categoría Ordinaria

Salud Pública

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Juan Gana

Gastroenterólogo Pediatra

Departamento de Gastroenterología y Nutrición Pediátrica.

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Orlando Diaz

Profesor Asociado

Enfermedades Respiratorias

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Alex Escalona

Assistant Professor

Cirugía Digestiva

Pontificia Universidad Catolica de Chile

Santiago, Chile

Javier Tinoco

Jefe Unidad de de IAAS

Medicina Interna

Clinica Universidad de Los Andes

Santiago, Chile

Arturo Borzutzky

Chief; Associate Professor

Department of Pediatric Infectious Diseases and Immunology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Alberto Espino

Jefe Unidad Endoscopia Hospital Clínico UC-Christus

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

Nancy Farfán

Post-doc.

Farmacología

Universidad de Chile

Santiago, Chile

IVAN CALDERON

Associate Professor / Principal Investigator/ Master in Biotechnology & Life Sciences Director

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

Jeannette Dabanch

Medico Infectóloga

Medicina Interna Nortee

Hospital Clínico Universidad de Chile

Santiago, Chile

Hernán Peñaloza

Postdoctoral associate

Department of Medicine

University of Pittsburgh

Pittsburgh, Estados Unidos

Santiago, Chile

Nicolas Jarufe

Chief Digestive Surgery

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

Sergio González

FACULTAD DE MEDICINA. PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

MARIO CALVO

Profesor Asociado

Instituto de Medicina

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

Luis Villarroel

Profesor Asociado

Salud Publica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE SALUD PÚBLICA

Santiago, Chile

Marcela Quintanilla

Coordinadora Unidad de Investigación

Facultad Enfermeria y Obstetricia

Universidad de los Andes

Santiago, Chile

fresia ferreccio

Full Professor, Director PhD Epidemiolgy Program

Public Health

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE FACULTAD DE MEDICINA, ESCUELA DE MEDICINA, DEPARTAMENTO DE SALUD PÚBLICA.

Santiago, Chile

Ana Guzman

MÉDICO JEFE LABORATORIO

LABORATORIO CLÍNICO

PONTIFICIA UNIVERSIDAD CATÓLICA

SANTAIGO, Chile

José Zoroquiain

PONTIFICIA UNIVERSIDAD CATÓLICA

SANTIAGO, Chile

Manuel Marcelo Alvarez Lobos

Líneas de Investigación

Educación

Medico Cirujano, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1994

Internal Medicine Residence (specialist), PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997

Gastroenterology fellowship (Specialist), PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009

Experiencia Académica

Associated Professor Full Time

Experiencia Profesional

Chief of Institute of Medicine Other

Formación de Capital Humano

Premios y Distinciones

Dr. Gabriel Letelier Award

Chief of residents in Internal Medicine

"Dr Ivan Marinovic" Award

poster of distinction

Dr Jaime Chesta Award

Clinical Excellence Junior 2010 Award

"Emilio Saval 2012" Award

Article (52)

Abstract (7)

CaseReport (1)

Errata (1)

Letter (3)

Proyecto (13)

"Estudio del efecto de la latitud sobre la prevalencia de las enfermedades Inflamatorias Intestinales en Chile.

=> "Caracterización clínica y microbiológica de las diarreas intrahospitalarias asociadas a Clostridium difficile en pacientes adultos del Hospital Clínico de la Universidad Católica".

Estructuración de un protocolo clínico de enfrentamiento de las diarreas intrahospitalarias, de acuerdo a la epidemiología local del Clostridium difficile y el perfil clínico de la infección, en dos centros hospitalarios.

Ribotipificación Clínica y ambiental del Clostridium difficile en un hospital Universitario y su relación con las diarreas intrahospitalarias”.

ROLE OF HEME OXYGENASE-1 IN ACUTE AND CHRONIC INTESTINAL INFLAMATION=> INFECTIOUS AND IMMUNE MODELS.

“EFECTO DE LOS NIVELES DE VITAMINA D EN LINFOCITOS T REGULADORES EN SANGRE PERIFÉRICA EN PACIENTES CON ENFERMEDAD INFLAMATORIA INTESTINAL”.

CELLULAR AND MOLECULAR MECHANISMS RELEVANT IN THE INTERACTION OF CLINICAL ISOLATES OF ADHERENT INVASIVE ESCHERICHIA COLI (AIEC) WITH EPITHELIAL CELLS OR MACROPHAGES IN CROHN S DISEASE

Tabaco como factor de riesgo para infecciones entéricas por Salmonella.

Mecanismos de patogenicidad del Clostridium Difficile y sus implicancias clínicas.

ROLE OF ST2/IL-33 SYSTEM IN MUCOSAL INFLAMMATION AND INFLAMMATORY BOWEL DISEASES PATHOGENIA

EVALUATION OF SALMONELLA ENTERICA CAPACITY TO PROMOTE INFLAMMATORY BOWEL DISEASE IN SUSCEPTIBLE HOST

ALTERACIONES DEL METABOLISMO HEPATICO DEL COLESTEROL Y ACIDOS BILIARES EN LA PATOGENIA DE LA COLETIASIS.

PATOLOGIA MOLECULAR DE LA FORMACION DE CALCULOS VESICULARES DE COLESTEROL Y ROL DE LA PROTEINA SCP-2 EN EL TRANSPORTE Y SECRECION HEPATICA DE COLESTEROL.

Review (3)