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Marcelo Andres Lopez Lastra

Profesor Titular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Virologia Molecular; Virus de RNA; Interaccion virus-hospedero; Mecanismos de iniciacion de la traduccion de mRNAs virales.

Biochemist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1994
Microbiology, UNIVERSIDAD DE CHILE. Chile, 1999
Clinical Research, UNIVERSITE CLAUDE BERNARD LYON I. Francia, 1999

Post-Doctoral Fellow Full Time

ECOLE NORMALE SUPERIEURE DE LYON

Unité de Virologie Humaine

Lyon, Francia

1999 - 2000
Post-Doctoral Fellow Full Time

MCGILL UNIVERSITY

Medicine

Montreal, Canada

2000 - 2004
Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Santiago, Chile

2004 - 2010
Associated Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicine

Santiago, Chile

2011 - 2018
Full Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Medicina

Santiago, Chile

2018 - At present

ANRS Post-Doctoral Fellow Full Time

Ecole Normal Superior de Lyon

Lyon, Francia

1999 - 2000
Professor Full Time

Pontificia Universidad Catolica de Chile

Santiago, Chile

2004 - At present
CIHR Post-Doctoral Fellow Full Time

McGill University

Montreal, Canada

2000 - 2004

Training of Students:

a- Supervised Undergraduate theses or dissertations.

1- Alejandra Vásquez. Use of DNA shuffling as a tool to identify functional domains required for IRES activity. Biologist, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile.
Awarded June 2007.
2- Karla Tapia. Study of the 5'UTR of the MMTV retrovirus possible role in translation initiation. Biochemist. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded
December 2008.
3- Cristian Holzmann. The function of the HIV-1 REV protein on translation initiation of the full-length viral mRNA. Biochemist. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de
Chile. Awarded May 2009.
4- Pablo Rambohr. Development of an in vitro system to study HIV-1 IRES activity. Biochemist. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded March 2010.
5- Matías Rivero. Study of the translation initiation mechanism of the full-length HIV-1 mRNA; characterization of a dual mechanism of initiation. Biochemist. Universidad de Chile. Awarded September
2011.
6- Carla del Barrio. Study of the putative Gag-IRES in the context of the full-length HIV-1 mRNA. Biologist, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded in June
2011.
7- Fernando Lowy. Characterization of the IRES activity present within the full-length mRNA of MMTV. Biochemist. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded
April 2012.
8- Felipe Carvajal. Study of the HIV-1 IRES activity in mRNAs isolated from clinical samples. Biochemist. Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded
September 2012.
9- Federico Rossi. Study of cap-independent translation initiation of the full-length HIV-1 mRNA. Biologist, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded, July 4,
2012.
10- Carlos Joaquin Caceres. IRES activity as a target for the development of novel antiviral strategies. Biochemist, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded,
April 19, 2013.
11- Hade Ramos. Staufen-1 and snRNP70 play a role in HIV-1 IRES-mediated translation initiation. Biochemist, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile. Awarded,
September 3, 2020.

b- Supervised Medical Residence Thesis:

Patricio Astudillo. Correlation between IL28B genotype and the clinical severity of bronchiolitis in pediatric patients. Residency thesis in Pediatrics. Awarded, April 2018.

c- Supervised Master Thesis:

1- Constanza Pino. PTB is an ITAF for the MMTV-IRES. Biochemist/Master’s Degree. Awarded in September 2011. Facultad de Ciencias de la Salud. Universidad Andrés Bello.
2- Patricio Astudillo. Clinical phenotyping of viral bronchiolitis patients at hospitalization: clinical characteristics and associated outcomes. Master’s in medical research, School of Medicine, Pontificia
Universidad Católica de Chile. Awarded on October 12, 2022.

d- Supervised Graduate Thesis (Ph.D.):

1- Maria Inés Barría. "Study of the HCV IRES identifying novel targets for developing antiviral compounds". Doctor en Ciencias, mención Microbiología. Universidad de Chile. Awarded in November
2008. Current position: Professor Universidad San Sebastian, Puerto Montt, Chile.
2- Andrea Rivas-Aravena. "Study of the mechanism of translation initiation of the full-length HIV-1 mRNA; the role of cellular protein on IRES activity". Doctor en Biología mención Biología Molecular y
Celular. Pontificia Universidad Católica de Chile. Awarded in May 2009. Current position: Professor Universidad San Sebastian, Santiago, Chile.
3- Jorge Vera-Otarola. "Study of the mechanism of translation initiation of the small Andes virus mRNA". Doctor en Microbiología, Universidad de Santiago. Awarded in March 2010. Current position:
Research Associate, Applied Virology Unit, Pontificia Universidad Católica de Chile, Pontificia Universidad Catolica de Chile.
4- Fernando Valiente-Echeverría. "Regulation of the HIV-1 IRES by INS elements present within the Gag coding region". Doctor en Microbiología, Universidad de Santiago. Awarded in May 2010.
Current position: Professor Universidad de Chile, Santiago, Chile.
5- Maricarmen Vallejos García. "Structural and functional study of 5'UTR of the full-length HIV-1 mRNA". Doctor en Ciencias Médicas, Facultad de Medicina, Pontificia Universidad Católica de Chile.
Awarded in September 2011. Current position: Post-Doctoral fellow, Institut Curi, France.
6- Alejandro Letelier. "Identifying novel Cis-acting elements that modulate retroviral IRES activity". Doctorado en Ciencias Biológicas mención Genética Molecular y Microbiología, Pontificia
Universidad Católica de Chile. Awarded in October 2013.
7- Jenniffer Angulo. "Host-virus relationship in the context of an HCV infection". Awarded on May 13, 2014. Doctorado en Microbiología, Universidad de Santiago. Current position: Professor, School
of Medicine, Pontificia Universidad Catolica de Chile.
8- Eduardo Olivares. "Study of the mechanism of translation initiation driven by the 5'UTR of the HTLV-1 full-length mRNA". Doctorado en Microbiología, Universidad de Santiago. Awarded on April 1,
2015. Current position: Senior Oncology Medical Science Liaison (MSL), AstraZeneca Oncology and Immunotherapy Medical Science Liaison (MSL), AstraZeneca, Santiago, Chile.
9- Estefanía Castillo. "Study of the mechanism of translation initiation of the Small Andes virus mRNA". Doctorado en Ciencias Biológicas mención Genética Molecular y Microbiología, Pontificia
Universidad Católica de Chile. Awarded, 19-Agosto. 2015. Current Position: Oncology Medical Science Liaison, AstraZeneca.
10- Loretto Solis. "The Small RNA of ANDV encodes for the NSs protein; A possible role as an antagonist of Type I INF response". Doctorado en Ciencias, mención Microbiología. Universidad de Chile.
Awarded, 5-October, 2015.
11- Fernando Lowy. "ANDV NSs protein induces eIF2-alfa phosphorylation and stress granule formation". Doctorado en Ciencias Biológicas mención Genética Molecular y Microbiología, Pontificia
Universidad Católica de Chile. Awarded, October 26, 2016.
12- Carlos Joaquin Caceres. "Study of the mechanism of translation initiation of the HTLV-1 mRNAs encoding the HBZ proteins". Doctorado en Ciencias, mención Microbiología. Universidad de Chile.
Awarded, June 30, 2017. Current Position: Research Associate, University of Georgia, USA.
13- Natalia Contreras. "Implications of cellular proteins PTB, nucleolin, and hnRNP U on IRES-mediated translation initiation of retroviral mRNAs". Doctorado en Biología, mención Microbiología.
Universidad de Chile. Awarded, April 27, 2018. Current position: Professor Universidad Andres Bello, Santiago, Chile.
14- Felipe Carvajal. "RNA structures and their impact on translation initiation of the HIV-1 and ANDV mRNAs". Doctorado en Ciencias Biológicas mención Genética Molecular y Microbiología, Pontificia
Universidad Católica de Chile. Awarded, March 28, 2019. Post-Doctoral Fellow.
15- Valeria Olguín. "The heterogeneous ribonuclear protein K (hnRNP K) is an IRES trans-acting factor for the HIV-1, HTLV-1, and MMTV internal ribosome entry sites". Doctorado en Ciencias
Médicas, Facultad de Medicina, Pontificia Universidad Católica de Chile. Awarded, January 15, 2020. Current position: Research Associate, Universidad del Desarrollo, Santiago, Chile.
16- Leandro Fernández. "Characterization of Dengue virus mRNA IRES-dependent translation initiation; the role of PTB as an ITAF". Doctorado en Ciencias, mención Microbiología. Universidad de
Chile. Awarded, August 31, 2020. Current position: Research Associate, University of Virginia
17- Aldo Barrera. "Post-translational modifications of IRES trans-acting factors hnRNP A1 and HuR impact on the activity of retroviral IRESs". Doctorado en Ciencias Biológicas mención Genética
Molecular y Microbiología, Pontificia Universidad Católica de Chile. Awarded, November 4, 2020. Current position: Post-Doctoral Fellow, School of Medicine, Pontificia Universidad Catolica de Chil.
18- Fabian Díaz. "Development of recombinant BCG vaccines targeting Andes orthohantaviruses and Respiratory syncytial virus: Evaluation on murine and bovine models. Doctorado en Ciencias
Biológicas mención Genética Molecular y Microbiología, Pontificia Universidad Católica de Chile. Awarded, August 3, 2021. Co-Tutor together with Dr. Alexis Kalergis.
19- Yazmin Fuentes. "HnRNPK post-translational modifications regulate HIV-1 IRES activity". Doctorado en Microbiología, Universidad de Santiago. Awarded, May 12, 2023. Postdoctoral fellow
Universidad de Concepción.
20- Brenda López-Ulloa. “HnRNPA1 and HuR differentially modulate cap-independent translation initiation from the HTLV-1 IRES and the sHBZ IRES”. Doctorado en Ciencias Biológicas mención
Genética Molecular y Microbiología, Pontificia Universidad Católica de Chile. Awarded, October 10, 2023. Current position: Professor, Universidad Politécnica Salesiana, UPS, Grupo de
Investigación en Aplicaciones Biotecnologicas, GIAB, Carrera de Biotecnología,
21- Dafne Mendonca (in progress). Doctorado en Ciencias Médicas, Facultad de Medicina, Pontificia Universidad Católica de Chile.
22- Patricio Astudillo (in progress). Doctorado en Ciencias Médicas, Facultad de Medicina, Pontificia Universidad Católica de Chile.

e- Post-Doctoral trainees:

1- Dr. Delphine Marsac. "Ex vivo infection of human dendritic cells (DCs) with Andes Hantavirus: Effect on the production of cytokines and matrix metalloproteases by DCs" FONDECYT-
POSTDOCTORADO-2008–3085029 (November 2007-November 2010).
2- Dr. Maricarmen Vallejos García. "Translational control of HIV-1 gene expression", IMII-Post-Doctoral fellow (September 2011-March 2013).
3- Dr. Julio Cartagena "Characterization of cytoplasmic granules associated with the expression of the ANDV NSs protein". IMII-post-doctoral fellow (March 2012-April 2013).
4- Dr. Jenniffer Angulo. "Mechanism of translation initiation on the ANDV SmRNA; selection of the initiation codon". ACT 1408 Post-Doctoral Fellow (November 2016-November 2018).
5- Dr. Barbara Rojas "Evaluation of the impact of lncRNAs on retroviral IRES function" (April 2023-April 2024).

Abraham Stekel fellowship

UNIVERSIDAD DE CHILE

Chile, 1993

Talented young scientist award granted by Nestle International Corporation and Universidad de Chile (INTA)
Abraham Stekel fellowship

INTA

Chile, 1994

Talented young scientist award granted by Nestle International Corporation and Universidad de Chile (INTA)
Abraham Stekel fellowship

UNIVERSIDAD DE CHILE

Chile, 1995

Talented young scientist award granted by Nestle International Corporation and Universidad de Chile (INTA)
Doctoral Fellowship

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 1995

CONICYT Doctoral fellowship
Rhone-Alpes Doctoral Fellowship

Rhone-Alpes

Francia, 1996

Fellowship given by the Rhone-Aples region. Lyon, France.
Post-Doctoral followship

Agence national de recherches sur le Sida

Francia, 1999

Post-Doctoral fellowship granted by the Frence Agence national de recherches sur le Sida.
Post-Doctoral Fellowship

Canadian Institutes of Health Research

Canada, 2001

Canadian Institutes of Health Research (CIHR) Post-Doctoral fellowship (#MFE–47704), Canada [Ranked 11th from 350 total applicants].
Visiting Professor

FIOCRUZ Institute at Rio de Janeiro

Brasil, 2013

Visisting Professor at the Fiocruz Institute at Rio de Janairo, Brasil.


Heterogeneous nuclear ribonucleoprotein K promotes cap-independent translation initiation of retroviral mRNAs. Fuentes Y, Olguín V, López-Ulloa B, Mendonça D, Ramos H, Abdalla AL, Guajardo-Contreras G, Niu M, Rojas-Araya B, Mouland AJ, López-Lastra M. Article ISI NUCLEIC ACIDS RESEARCH (2024)
Heterogeneous nuclear ribonucleoprotein K promotes cap-independent translation initiation of retroviral mRNAs Fuentes, Yazmin; Olguin, Valeria; Lopez-Ulloa, Brenda; Mendonca, Dafne; Ramos, Hade; Abdalla, Ana Luiza; Guajardo-Contreras, Gabriel; Niu, Meijuan; Rojas-Araya, Barbara; Mouland, Andrew J.; Lopez-Lastra, Marcelo Article ISI NUCLEIC ACIDS RESEARCH (2024)
Polypyrimidine-Tract-Binding Protein Isoforms Differentially Regulate the Hepatitis C Virus Internal Ribosome Entry Site Angulo, Jenniffer; Caceres, C. Joaquin; Contreras, Nataly; Fernandez-Garcia, Leandro; Chamond, Nathalie; Ameur, Melissa; Sargueil, Bruno; Lopez-Lastra, Marcelo Article ISI VIRUSES-BASEL (2023)
LDL particle size and antioxidant HDL function improve after sustained virological response in patients with chronic HCV Ignacio Vargas, Jose; Rivera, Katherine; Arrese, Marco; Benitez, Carlos; Barrera, Francisco; Hugo, Monrroy; Pablo Arab, Juan; Pino, Karla; Barrera, Aldo; Lopez-Lastra, Marcelo; Rigotti, Attilio; Soza, Alejandro Article ISI ANNALS OF HEPATOLOGY (2022)
RNA-Binding Proteins as Regulators of Internal Initiation of Viral mRNA Translation Lopez-Ulloa, Brenda; Fuentes, Yazmin; Pizarro-Ortega, Magdalena S.; Lopez-Lastra, Marcelo Article ISI VIRUSES-BASEL (2022)
The double-stranded RNA-binding protein, Staufen1 is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation Ramos, Hade; Monette, Anne; Niu, Meijuan; Barrera, Aldo; Lopez-Ulloa, Brenda; Fuentes, Yazmin; Guizar, Paola; Pino, Karla; DesGroseillers, Luc; Mouland, Andrew J.; Lopez-Lastra, Marcelo Article ISI NUCLEIC ACIDS RESEARCH (2022)
The Internal Ribosome Entry Site of Dengue Virus mRNA Is Active When Cap-Dependent Translation Initiation Is Inhibited Fernandez-Garcia, Leandro; Angulo, Jenniffer; Ramos, Hade; Barrera, Aldo; Pino, Karla; Vera-Otarola, Jorge; Lopez-Lastra, Marcelo Article ISI JOURNAL OF VIROLOGY (2021)
The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA Vera-Otarola, Jorge; Castillo-Vargas, Estefania; Angulo, Jenniffer; Barriga, Francisco M.; Batlle, Eduard; Lopez-Lastra, Marcelo Article ISI PLOS PATHOGENS (2021)
Cap-independent translation initiation of the unspliced RNA of retroviruses Barrera, Aldo; Olguin, Valeria; Vera-Otarola, Jorge; Lopez-Lastra, Marcelo Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2020)
Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients Astudillo P.; Angulo J.; Pino K.; de Carvalho J.B.; de Morais G.L.; Perez S.; de Vasconcelos A.T.R.; FerrÃ©s M.; LÃ³pez-Lastra M. Article ISI SCOPUS PEDIATRIC RESEARCH (2020)
Infectious and non-infectious diseases burden among Haitian immigrants in Chile: a cross-sectional study Fuster, Francisco; Peirano, Felipe; Ignacio Vargas, Jose; Xavier Zamora, Francisco; Lopez-Lastra, Marcelo; Nunez, Ruth; Soza, Jacinta; Gonzalez, Katherine; Estay, Denisse; Barchiesi, Beatrice; Fuster, Antonieta; Lopez, Ignacia; Utrera, Nicolas; Landeros, Jorge; Chandia, Javiera; Paredes, Angela; Reyes, Daniela; Arias, Rodrigo; Padilla, Luis; Suarez, Hernan; Farcas, Katia; Cannistra, Macarena; Munoz, Geraldine; Rodriguez, Ignacio; Ormazabal, Ivana; Cortes, Josefina; Cornejo, Barbara; Manzur, Franco; Reyes, Antonia; Leiva, Vicente; Raimann, Maria Victoria; Arrau, Catalina; Cox, Valentina; Soza, Alejandro Article ISI SCIENTIFIC REPORTS (2020)
Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation Barrera, Aldo; Ramos, Hade; Vera-Otarola, Jorge; Fernandez-Garcia, Leandro; Angulo, Jenniffer; Olguin, Valeria; Pino, Karla; Mouland, Andrew J.; Lopez-Lastra, Marcelo Article ISI NUCLEIC ACIDS RESEARCH (2020)
The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling Vera-Otaroola, Jorge; Solis, Loretto; Lowy, Fernando; Olguin, Valeria; Angulo, Jenniffer; Pino, Karla; Tischler, Nicole D.; Otth, Carola; Padula, Paula; Lopez-Lastra, Marcelo Article ISI JOURNAL OF VIROLOGY (2020)
A Single-Nucleotide Polymorphism of (V3) Integrin Is Associated with the Andes Virus Infection Susceptibility Martinez-Valdebenito, C; Angulo, J; Le Corre, N; Marco, C; Vial, C; Miquel, JF; Cerda, J; Mertz, G; Vial, P; Lopez-Lastra, M; Ferres, M Article ISI SCOPUS VIRUSES-BASEL (2019)
Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis? Urra, Soledad; Fischer, Martin C.; Martinez, Jose R.; Veliz, Loreto; Orellana, Paulina; Solar, Antonieta; Bohmwald, Karen; Kalergis, Alexis; Riedel, Claudia; Corvalan, Alejandro H.; Roa, Juan C.; Fuentealba, Rodrigo.; Caceres, C. Joaquin; Lopez-Lastra, Marcelo; Leon, Augusto; Droppelmann, Nicolas; Gonzalez, Hernan E. Article ISI SCOPUS ONCOTARGET (2018)
Hepatitis A outbreak since November 2016 affecting men who have sex with men (MSM) in Chile connected to the current outbreak in MSM in Europe, situation up to October 2017 Rivas, Violeta; Barrera, Aldo; Pino, Karla; Núñez, Ruth; Caceres, C. Joaquin; Lopez-Lastra, Marcelo; Soza, Alejandro Article ISI SCOPUS EUROSURVEILLANCE (2018)
IL28B gene polymorphism rs12979860, but not rs8099917, contributes to the occurrence of chronic HCV infection in Uruguayan patients Echeverría, Natalia; Chiodi, Daniela; López, Pablo; Sanchez Ciceron, Adriana; Angulo, Jenniffer; López-Lastra, Marcelo; Silvera, Paola; Canavesi, Adrian; Bianchi, Carla; Colistro, Valentina; Cristina, Juan; Hernandez, Nelia; Moreno, Pilar Article ISI SCOPUS VIROLOGY JOURNAL (2018)
Non-canonical translation initiation of the spliced mRNA encoding the human T-cell leukemia virus type 1 basic leucine zipper protein Cáceres, C Joaquín; Angulo, Jenniffer; Lowy, Fernando; Contreras, Nataly; Walters, Beth; Olivares, Eduardo; Allouche, Delphine; Merviel, Anne; Pino, Karla; Sargueil, Bruno; Thompson, Sunnie R; López-Lastra, Marcelo Article ISI SCOPUS Nucleic Acids Research (2018)
Detection of high biliary and fecal viral loads in patients with chronic hepatitis C virus infection Monrroy, Hugo; Angulo, Jenniffer; Pino, Karla; Labbé, Pilar; Miquel, Juan Francisco; López-Lastra, Marcelo; Soza, Alejandro Article ISI SCOPUS GASTROENTEROLOGIA Y HEPATOLOGIA (2017)
Hepatitis C virus may have an entero-hepatic cycle which could be blocked with ezetimibe Monrroy H.; López-Lastra M.; Soza A. Article ISI SCOPUS MEDICAL HYPOTHESES (2017)
Serum levels of interleukin-6 are linked to the severity of the disease caused by Andes Virus Angulo, Jenniffer; Martínez-Valdebenito, Constanza; Marco, Claudia; Galeno, Héctor; Villagra, Eliecer; Vera, Lilian; Lagos, Natalia; Becerra, Natalia; Mora, Judith; Bermúdez, Andrea; Díaz, Janepsy; Ferrés, Marcela; López-Lastra, Marcelo; Aguilar, Patricia V. Article ISI SCOPUS PLOS NEGLECTED TROPICAL DISEASES (2017)
Effect of ezetimibe in HCV viral load after liver transplantation. Monrroy-Bravo H, Angulo J, Pino K, Labbé P, López-Lastra M, Soza A. Article Annals of Hepatology (2016)
LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex. Angulo, Jenniffer; Ulryck, Nathalie; Deforges, Jules; Chamond, Nathalie; Lopez-Lastra, Marcelo; Masquida, Benoît; Sargueil, Bruno Article NUCLEIC ACIDS RESEARCH (2016)
Polypyrimidine tract-binding protein binds to the 5? untranslated region of the mouse mammary tumor virus mRNA and stimulates cap-independent translation initiation Cáceres C.J.; Contreras, N; Angulo J.; Vera-Otarola, J.; Pino-Ajenjo C.; Llorian M.; Ameur M.; Lisboa F.; Pino, K; Lowy F.; Sargueil B.; Lopez-Lastra, M Article ISI SCOPUS FEBS Journal (2016)
Structural domains within the HIV-1 mRNA and the ribosomal protein S25 influence cap-independent translation initiation Carvajal, Felipe; Vallejos, Maricarmen; Walters, Beth; Contreras, Nataly; Hertz, Marla I.; Olivares, Eduardo; Cáceres, Carlos J.; Pino, Karla; Letelier, Alejandro; Thompson, Sunnie R.; López-Lastra, Marcelo Article ISI SCOPUS FEBS JOURNAL (2016)
Targeting deoxyhypusine hydroxylase activity impairs cap-independent translation initiation driven by the 5'untranslated region of the HIV-1, HTLV-1, and MMTV mRNAs Cceres, C. Joaqun; Angulo, Jenniffer; Contreras, Nataly; Pino, Karla; Vera-Otarola, Jorge; Lpez-Lastra, Marcelo Article ISI SCOPUS ANTIVIRAL RESEARCH (2016)
Urinary leukotriene and Bcl I polymorphism of glucocorticoid receptor gene in preschoolers with recurrent wheezing and high risk of asthma Morales M.; Flores C.; Pino, K; Angulo J.; Lopez-Lastra, M; Castro-Rodriguez, JA Article ISI SCOPUS Allergol Immunopathol (2016)
Association of Single-Nucleotide Polymorphisms in IL28B, but Not TNF-alpha, With Severity of Disease Caused by Andes Virus Angulo J.; Pino, K; Echeverria-Chagas, N; Marco C.; Martinez-Valdebenito, C; Galeno, H; Villagra E.; Vera L.; Lagos, N.; Becerra, N; Mora J.; Bermúdez A.; Cárcamo M.; Díaz, J; Miquel, JF; Ferrés M.; Lopez-Lastra, M Article ISI SCOPUS Clinical Infectious Diseases (2015)
LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex Angulo J.; Ulryck N.; Deforges J.; Chamond N.; Lopez-Lastra, M; Masquida B.; Sargueil B. Article ISI SCOPUS NUCLEIC ACIDS RESEARCH (2015)
Vitamin D levels and vitamin D receptor gene polymorphisms in asthmatic children: a case-control study Einisman H; Reyes, ML; Angulo J.; Cerda, J; Lopez-Lastra, M; Castro-Rodriguez, JA Article ISI SCOPUS Pediatric Allergy and Immunology (2015)
The 5 ' Untranslated Region of the Human T-Cell Lymphotropic Virus Type 1 mRNA Enables Cap-Independent Translation Initiation Olivares, E.; Landry, DM; Caceres, CJ; Pino, K; Rossi F.; Navarrete C.; Huidobro-Toro, JP; Thompson, SR; Lopez-Lastra, M Article ISI SCOPUS JOURNAL OF VIROLOGY (2014)
Translation initiation of the HIV-1 mRNA Ohlmann, Theophile; Mengardi, Chloe; Lopez-Lastra, M Article (2014)
A cis-Acting Element Present within the gag Open Reading Frame Negatively Impacts on the Activity of the HIV-1 IRES Valiente-Echeverra, Fernando; Vallejos, Maricarmen; Monette, Anne; Pino, Karla; Letelier, Alejandro; Huidobro-Toro, J. Pablo; Mouland, Andrew J.; Lpez-Lastra, Marcelo; Jan, Eric Article ISI SCOPUS PLOS ONE (2013)
Dual Mechanisms of Translation Initiation of the Full-Length HIV-1 mRNA Contribute to Gag Synthesis Monette A; Valiente-Echeverria, F; Rivero M.; Cohen, EA; Lopez-Lastra, M; Mouland AJ Article ISI SCOPUS PLOS ONE (2013)
Genetic variations in host IL28B links to the detection of peripheral blood mononuclear cells-associated hepatitis C virus RNA in chronically infected patients Angulo J.; Pino, K; Pavez, C.; Biel, F; Labbé P.; Miquel, JF; Soza A.; Lopez-Lastra, M Article ISI SCOPUS Journal of Viral Hepatitis (2013)
IL28B Polymorphisms Among Latin American HCV Patients A. Soza; M. López Lastra Article Current Hepatitis Reports (2013)
Translation initiation is driven by different mechanisms on the HIV-1 and HIV-2 genomic RNAs de Breyne, S; Soto-Rifo, R; Lopez-Lastra, M; Ohlmann T. Article ISI VIRUS RESEARCH (2013)
Functional and Structural Analysis of the Internal Ribosome Entry Site Present in the mRNA of Natural Variants of the HIV-1 Vallejos, Maricarmen; Carvajal, Felipe; Pino, Karla; Navarrete, Camilo; Ferres, Marcela; HUIDOBRO-TORO, Juan Pablo; Sargueil, Bruno; Lpez-Lastra, Marcelo; Jang, Sung Key Article ISI SCOPUS PLOS ONE (2012)
The Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism Vera-Otarola, J; Solís L.; Soto-Rifo, R; Ricci E.P.; Pino, K; Tischler, N. D.; Ohlmann T.; Darlix J.-L.; Lopez-Lastra, M Article ISI SCOPUS Journal of Virology (2012)
Activity of the human immunodeficiency virus type 1 cell cycle-dependent internal ribosomal entry site is modulated by IRES trans-acting factors Vallejos, M.; Deforges J.; Plank, TDM; Letelier, A; Ramdohr P.; Abraham, CG; Valiente-Echeverria, F; Kieft, JS; Sargueil B.; Lopez-Lastra, M Article ISI SCOPUS Nucleic Acids Research (2011)
Infection of human monocyte-derived dendritic cells by ANDES Hantavirus enhances proinflammatory state, the secretion of active MMP-9 and indirectly enhances endothelial permeability Marsac D.; García S.; Fournet, A; Aguirre A.; Pino, K; Ferrés M.; Kalergis, AM; Lopez-Lastra, M; Veas, F. Article ISI SCOPUS Virology Journal (2011)
The 3 ' Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA Vera-Otarola, J; Soto-Rifo, R; Ricci, EP; Ohlmann T.; Darlix, JL; Lopez-Lastra, M Article ISI SCOPUS Journal of Virology (2010)
The 5'-untranslated region of the mouse mammary tumor virus mRNA exhibits cap-independent translation initiation Vallejos, M.; Ramdohr P.; Valiente-Echeverria, F; Tapia K.; Rodríguez FE; Lowy F.; Huidobro-Toro, JP; DANGERFIELD JA; Lopez-Lastra, M Article ISI NUCLEIC ACIDS RESEARCH (2010)
Analysis of natural variants of the hepatitis C virus internal ribosome entry site reveals that primary sequence plays a key role in cap-independent translation Barría MI; González A; Vera-Otarola, J; León U; Vollrath, V; Marsac D.; Monasterio O.; Perez-Acle, T; Soza A.; Lopez-Lastra, M Article ISI SCOPUS NUCLEIC ACIDS RESEARCH (2009)
Andes Virus Antigens Are Shed in Urine of Patients with Acute Hantavirus Cardiopulmonary Syndrome Godoy, P; Marsac D.; Stefas E.; Ferrer, P; Tischler, ND; Pino, K; Ramdohr P.; Vial, P.; Valenzuela PDT; Ferrés M.; Veas, F.; Lopez-Lastra, M Article ISI SCOPUS JOURNAL OF VIROLOGY (2009)
Hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naive chronically infected patients Vera-Otarola, J; Barría MI; León U; Marsac D.; Carvallo, P.; Soza A.; Lopez-Lastra, M Article ISI SCOPUS JOURNAL OF VIRAL HEPATITIS (2009)
Human Immunodeficiency Virus Type 1 (HIV-1) Induces the Cytoplasmic Retention of Heterogeneous Nuclear Ribonucleoprotein A1 by Disrupting Nuclear Import IMPLICATIONS FOR HIV-1 GENE EXPRESSION Monette A; Ajamian, L; Lopez-Lastra, M; Mouland AJ Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Is Single-Strand Conformation Polymorphism Analysis of the Full 5 ' Untranslated Region an Adequate Approach To Study Hepatitis C Virus Quasispecies Distribution? Vera-Otarola, J; Barría MI; León U; Carvallo, P.; Soza A.; Lopez-Lastra, M Article ISI SCOPUS JOURNAL OF VIROLOGY (2009)
Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein Charnay, N; Ivanyi-Nagy, R; Soto-Rifo, R; Ohlmann T.; Lopez-Lastra, M; Darlix, JL Article ISI SCOPUS Retrovirology (2009)
The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites Rivas-Aravena, A; Ramdohr P.; Vallejos, M.; Valiente-Echeverria, F; Dormoy-Raclet, V; Rodriguez,F; Pino, K; HOLZMANN C; Huidobro-Toro, JP; GALLOUZI IE; Lopez-Lastra, M Article ISI SCOPUS VIROLOGY (2009)
Influence of extrahepatic viral infection on the natural history of hepatitis C Barría MI; Vera-Otarola, J; León U; Vollrath, V; Marsac D.; Riquelme A.; Lopez-Lastra, M; Soza A. Article ISI SCOPUS ANNALS OF HEPATOLOGY (2008)
Hepatitis C in Chile: Burden of the disease Hepatitis C en Chile: Magnitud del problema Soza R A.; Lopez-Lastra, M Article REVISTA MEDICA DE CHILE (2006)
Complete translation of the hepatitis C virus genome in vitro: Membranes play a critical role in the maturation of all virus proteins except for NS3 Svitkin, YV; Pause, A; Lopez-Lastra, M; Perreault, S; Sonenberg, N Article ISI SCOPUS JOURNAL OF VIROLOGY (2005)
Dicistronic MLV-retroviral vectors transduce neural precursors in vivo and co-express two genes in their differentiated neuronal progeny Derrington, EA; Lopez-Lastra, M; Darlix, JL Article ISI SCOPUS Retrovirology (2005)
Protein synthesis in eukaryotes: The growing biological relevance of cap-independent translation initiation Lopez-Lastra, M; Rivas, A; Barría MI Article BIOLOGICAL RESEARCH (2005)
Detection of the infectious hematopoietic necrosis virus directly from infected fish tissues by dot blot hybridization with a non-radioactive probe González M.P.; Sanchez X.; Ganga, M.A; Lopez-Lastra, M; Jashes, M.; Sandino, A.M. Article JOURNAL OF VIROLOGICAL METHODS (1997)
Determination of Gizzerosine Activity in Fish Meal with a Homologous Radioimmunoassay Rosselot, G; Lopez-Lastra, M; Mcmurtry J.P. Article POULTRY SCIENCE (1996)
Inhibitors of infectious pancreatic necrosis virus (IPNV) replication Jashes, M.; Gonzalez, M.; Lopez-Lastra, M; Sandino,A; De Clercq, E Article ANTIVIRAL RESEARCH (1996)
A DETECTION METHOD FOR INFECTIOUS PANCREATIC NECROSIS VIRUS (IPNV) BASED ON REVERSE TRANSCRIPTION (RT)-POLYMERASE CHAIN-REACTION (PCR) LOPEZLASTRA, M; GONZALEZ, M; JASHES, M; SANDINO, AM Article ISI JOURNAL OF FISH DISEASES (1994)
Hepatitis C in Chile: Burden of the disease Soza A.; Lopez-Lastra, M Article REVISTA MEDICA DE CHILE


PILOT STUDY OF EZETIMIBE FOR CHRONIC HEPATITIS C INFECTION: EFFECT OF TREATMENT IN PLASMA, BILE AND STOOL VIRAL LOAD IN HUMANS Monrroy, H.; Angulo J.; Pino, K; Miquel, JF; Benítez C.; Arrese M.; Barrera F.; Norero B.; Wolff R.; Labbé P.; Lopez-Lastra, M; Soza A. Abstract ISI JOURNAL OF HEPATOLOGY (2015)
Analysis of genetic determinants associated with therapy response against hepatitis C virus: first study of IL28B polymorphisms in Uruguayan patients Echeverria-Chagas, N; Fischer, S; Boschi, S; Uriarte, R; Angulo J.; Lopez-Lastra, M; Moratorio, G; Cristina, J; Moreno, P Abstract JOURNAL OF VIRAL HEPATITIS (2013)
Impact of RNA nuclear experience on protein synthesis: the case of the HIV-1 mRNA Vallejos, M.; Monette A; Deforges J.; Plannk, TDM; Kieft, JS; Sargueil B.; Mouland AJ; Lopez-Lastra, M Abstract ISI FEBS JOURNAL (2012)
ApOH-capture technology enhances Andes hantavirus detection allowing virus concentration from plasma and urine samples of patients with acute hantavirus cardiopulmonary syndrome Godoy, P; Stefas E.; Ferrer, P; Vollrath, V; Vial, P.; Ferrés M.; Veas, F.; Lopez-Lastra, M Abstract INFECTION GENETICS AND EVOLUTION (2008)


Virus de la inmunodeficiencia humana Marcelo Lopez; Avendaño, LF; Ferres, M.; Spencer, E BookSection (2011)
Virus Hepatitis C Marcelo Lopez; Alejandro Soza; Avendaño, L.F.; Ferres, M.; Spencer, E. BookSection (2011)


EGULATING THE REGULATORS; THE IMPACT OF IRES-TRANSACTING FACTORS AND THEIR POST-TRANSLATIONAL MODIFICATIONS ON RETROVIRAL-IRES ACTIVITY. Lopez-Lastra, M Proyecto (2021)
Hepatitis B virus (HBV) infection in Haitian immigrants in Chile=> Determination of HBV genotypes, viral escape mutants and host factors influencing response to vaccination. FONDECYT (1191389) Proyecto 2019-2022 Coinvestigador(a)
Laboratoire International Associé/CNRS International Associated Laboratory CNRS-France (LIA) Proyecto 2018-2021 Inv. Principal
Identifying RNA-Binding Proteins (RBP) that act as Transacting factors for retroviral internal ribosome entry sites (IRESs); role RBP in retroviral IRES-mediated protein synthesis FONDECYT (11705090) Proyecto 2017-2020 Inv. Principal
Understanding the role of the DEAD-box helicase DDX3 in viral and cellular messenger RNA metabolism. PCI (C1eb03) Proyecto 2016-2018 Coinvestigador(a)
Patogeneis Molecular de Virus Emergentes. PIA (Anillo1408) Proyecto 2015-2018 Director(a)
Mejoramiento del equipamiento estratégico del laboratorio de bioseguridad de nivel 3 (BSL-3) de la Escuela de Medicina de la Pontificia Universidad Católica de Chile FONDEQUIP (EQM-130092) Proyecto 2014-2015 Inv. Principal
Hepatitis C virus exploits the hepatic lipid pathways=> Role of NPC1L1 in HCV infection FONDECYT (1130357) Proyecto 2013-2016 Coinvestigador(a)
Laboratoire International Associé/CNRS International Associated Laboratory CNRS-FRANCE (LIA) Proyecto 2013-2016 Inv. Principal
Study of the mechanism of translation initiation of retroviral mRNAs; the role of cellular proteins and RNA structure FONDECYT (1130270) Proyecto 2013-2016 Inv. Responsable
The atlas of the HIV-1 genomic messenger ribonucleoprotein (mRNP) complex PCI (USA2013-5) Proyecto 2013-2015 Coinvestigador(a)
Characterization of cellular factors involved in HIV-1 and HIV-2 genomic RNA translational control PCI (C11 S01) Proyecto 2012-2014 Inv. Principal
Investigación y desarrollo de herramientas bioinformáticas para el diseño costo‐efectivo de biosensores y biointerruptores moleculares FONDEF (CA12i10296) Proyecto 2012-2014 Coinvestigador(a)
Andes virus transmission and pathogenesis in Chile. NIH/International Collaborations in Infectious Disease Research (ICIDR) (2U01AI045452-11) Proyecto 2011-2015 Coinvestigador(a)
Institito de Inmunologia e Inmunoterapia Iniciativa Científica Milenio del Ministerio de Economía, Fomento y Turismo (P09/016-F) Proyecto 2011-2021 Coinvestigador(a)
Characterization and inhibition of the Gc multistep fusion mechanism used by Hantavirases to infect target cells FONDECYT (1100756) Proyecto 2010-2013 Coinvestigador(a)
Molecular mechanism ruling HIV and HCV translation initiation PCI (2009-158) Proyecto 2010-2011 Inv. Principal
Núcleo Milenio de Inmunología e Inmunoterapia Iniciativa Científica Milenio del Ministerio de Economía, Fomento y Turismo Proyecto 2009-2011 Coinvestigador(a)
Translation of the HIV-1 full length mRNA is regulated by cellular proteins that modulate the shift from cap-dependent to an IRES-dependent mode of initiation=> unveiling the basis of HIV-1 mRNA translational control FONDECYT (1090318) Proyecto 2009-2013 Inv. Responsable
Rol de la replicación extrahepática del virus de hepatitis C en la predicción de la respuesta a la terapia antiviral FONDECYT (1080323) Proyecto 2008-2010 Coinvestigador(a)
IDENTIFICACION DE LAS PROTEINAS Y LOS ELEMENTOS CIS QUE PARTICIPAN EN LA REGULACION DE LA INICIACION DE LA TRADUCCION DEPENDIENTE DE SITIO INTERNO DE ENTRADA DE RIBOSOMAS (IRES) DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA PCI (7070200) Proyecto 2007-2008 Inv. Responsable
CAPTURE AND ENRICHMENT OF EMERGING PATHOGENS FOR MULTIPLE AND ULTRA-SENSITIVE DIAGNOSTIC (USDEP) FP6-LIFESCIHEALTH (37560) Proyecto 2006-2010 Coinvestigador(a)
Development of lead compounds as fusion inhibitors for Dengue virus. ITC-Americas, Army Material Command. Department of State. USA (06-001) Proyecto 2006-2009 Coinvestigador(a)
Human immunodeficiency virus type 1 (HIV-1) internal ribosome entry segment (IRES); Identification of trans-acting factors and cis-acting elements involved in IRES function FONDECYT (1060655) Proyecto 2006-2008 Inv. Responsable
Investigating and Targeting the mechanism of HIV-1 protein synthesis. PCI (C05 S01) Proyecto 2006-2008 Inv. Principal
Recherches sur le plans diagnostic et physiopathologique chez les Virus Emergents JEAI-IRD (LVMEIE) Proyecto 2006-2008 Inv. Responsable
Rol de la replicación extra-hepática del virus de la hepatitis C en la expresión clinica e historia natural de la enfermedad FONDECYT (1050782) Proyecto 2005-2007 Coinvestigador(a)


Translation initiation of viral mRNAs Lopez-Lastra, M; Ramdohr P.; Letelier, A; Vallejos, M.; Vera-Otarola, J; Valiente-Echeverria, F Review ISI SCOPUS Reviews in Medical Virology (2010)
Translational control of retroviruses Balvay, L; Lastra, ML; Sargueil B.; Darlix, JL; Ohlmann T. Review ISI NATURE REVIEWS MICROBIOLOGY (2007)
Hepatitis C en Chile: Magnitud del problema Soza R, Alejandro; Lopez Lastra, Marcelo Review SCIELO REVISTA MEDICA DE CHILE (2006)

Marcelo Lopez

Profesor Titular

Infectologia e Inmunologia Pediatrica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Jenniffer Angulo

Asistente de Investigación

Pediatría e Inmunologia Pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

Marcela Ferres

Head of Department

Pediatric Infectious Diseases and Immunology

Pontificia Universidad Católica de Chile

Santiago, Chile

Aldo Barrera

Postdoctor

Enfermedades Infecciosas e Inmunología pediátrica

Pontificia Universidad Católica de Chile

Santiago, Chile

Fernando Valiente

Profesor Asociado

ICBM

Universidad de Chile

Santiago, Chile

Ricardo Soto

PROFESOR ASOCIADO

FACULTAD DE MEDICINA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Maria Barria

Investigador, Associate Professor

Universidad San Sebastián

Puerto Montt, Chile

Valeria Olguín

Lab Manager

Universidad del Desarrollo

Santiago, Chile

Hugo Monrroy

Instructor Adjunto

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

Juan Miquel

Full Professor

Gastroenterology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Jose Castro

Profesor Asociado

Cardiologia y Neumologia Pediatrica

Pontificia Universidad Catolica de Chile

Santiago, Chile

Felipe Carvajal

Investigador Postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

Eduardo Olivares

Director area biomedicina

Diagnóstico molecular

Bioingentech

santiago, Chile

Juan Roa

Chair

Pathology

Pontificia Universidad Catolica de Chile

santiago, Chile

Patricio Astudillo

Residente Pediatría

Urgencia General

Clínica Alemana De Santiago

Santiago, Chile

Maria Vial

Associate Professor/Profesor Asociado

Instituto de Ciencias e Innovación de Medicina

UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

Claudia Marco

Jefe de Unidad

Gerencia de Innovación y transformación Digital

Red de Salud UC CHRISTUS

Santiago, Chile

Constanza Martinez

Investigador asistente

Enfermedades infecciosas e inmunologia pediatrica

Pontificia Universidad Católica de Chile

Santiago, Chile

Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

Paulina Orellana

Coordinadora traslacional

Universidad de Chile

Santiago, Chile

Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

Karen Bohmwald

Investigador Postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo Valenzuela

Founder and Scientific Director

Fundación Ciencia & Vida

Santiago, Chile

Francisco Barrera

Profesor Asociado

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

Nicole Tischler

Investigadora Titular

Molecular Virology Laboratory

Fundación Ciencia para la Vida

Santiago, Chile

Monique Le Corre

Assistant Professor

Faculty of medicine, Pediatric division

Pontificia Universidad Catolica de Chile

Santiago, Chile

CARLOS FLORES

JEFE UTI

PEDIATRIA

HOSPITAL DE OVALLE

OVALLE, Chile

Marcela Cárcamo

Profesor

Epidemiología y Estudios en Salud

Universidad de Los Andes

Santiago, Chile

Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Jose Ignacio Vargas

Assistant Professor

GASTROENTEROLOGY

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

Estefania Castillo

Asistente de Investigación

Facultad de Ciencias Biológicas

Pontificia Universidad Católica de Chile

Santiago, Chile

Cristián Holzmann

Director ejecutivo

Kelumilla

Santiago, Chile

Ana Sandino

Profesor Titular

Biología

Universidad de Santiago de Chile

Santiago, Chile

Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Octavio Monasterio

Profesor Titular

Departamento de Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

Katherine Rivera

PhD (c) student in Medical Science

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo Vial

Professor

School of Medicine

ICIM/UNIVERSIDAD DEL DESARROLLO - CLÍNICA ALEMANA

Santiago, Chile

Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

Marcelo Andres Lopez Lastra

Líneas de Investigación

Educación

Biochemist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 1994

Microbiology, UNIVERSIDAD DE CHILE. Chile, 1999

Clinical Research, UNIVERSITE CLAUDE BERNARD LYON I. Francia, 1999

Experiencia Académica

Post-Doctoral Fellow Full Time

Post-Doctoral Fellow Full Time

Assistant Professor Full Time

Associated Professor Full Time

Full Professor Full Time

Experiencia Profesional

ANRS Post-Doctoral Fellow Full Time

Professor Full Time

CIHR Post-Doctoral Fellow Full Time

Formación de Capital Humano

Premios y Distinciones

Abraham Stekel fellowship

Abraham Stekel fellowship

Abraham Stekel fellowship

Doctoral Fellowship

Rhone-Alpes Doctoral Fellowship

Post-Doctoral followship

Post-Doctoral Fellowship

Visiting Professor

Article (60)

Abstract (4)

BookSection (2)

Proyecto (27)

Hepatitis B virus (HBV) infection in Haitian immigrants in Chile=> Determination of HBV genotypes, viral escape mutants and host factors influencing response to vaccination.

Laboratoire International Associé/CNRS International Associated Laboratory

Identifying RNA-Binding Proteins (RBP) that act as Transacting factors for retroviral internal ribosome entry sites (IRESs); role RBP in retroviral IRES-mediated protein synthesis

Understanding the role of the DEAD-box helicase DDX3 in viral and cellular messenger RNA metabolism.

Patogeneis Molecular de Virus Emergentes.

Mejoramiento del equipamiento estratégico del laboratorio de bioseguridad de nivel 3 (BSL-3) de la Escuela de Medicina de la Pontificia Universidad Católica de Chile

Hepatitis C virus exploits the hepatic lipid pathways=> Role of NPC1L1 in HCV infection

Laboratoire International Associé/CNRS International Associated Laboratory

Study of the mechanism of translation initiation of retroviral mRNAs; the role of cellular proteins and RNA structure

The atlas of the HIV-1 genomic messenger ribonucleoprotein (mRNP) complex

Characterization of cellular factors involved in HIV-1 and HIV-2 genomic RNA translational control

Investigación y desarrollo de herramientas bioinformáticas para el diseño costo&#8208;efectivo de biosensores y biointerruptores moleculares

Andes virus transmission and pathogenesis in Chile.

Institito de Inmunologia e Inmunoterapia

Characterization and inhibition of the Gc multistep fusion mechanism used by Hantavirases to infect target cells

Molecular mechanism ruling HIV and HCV translation initiation

Núcleo Milenio de Inmunología e Inmunoterapia

Translation of the HIV-1 full length mRNA is regulated by cellular proteins that modulate the shift from cap-dependent to an IRES-dependent mode of initiation=> unveiling the basis of HIV-1 mRNA translational control

Rol de la replicación extrahepática del virus de hepatitis C en la predicción de la respuesta a la terapia antiviral

IDENTIFICACION DE LAS PROTEINAS Y LOS ELEMENTOS CIS QUE PARTICIPAN EN LA REGULACION DE LA INICIACION DE LA TRADUCCION DEPENDIENTE DE SITIO INTERNO DE ENTRADA DE RIBOSOMAS (IRES) DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA

CAPTURE AND ENRICHMENT OF EMERGING PATHOGENS FOR MULTIPLE AND ULTRA-SENSITIVE DIAGNOSTIC (USDEP)

Development of lead compounds as fusion inhibitors for Dengue virus.

Human immunodeficiency virus type 1 (HIV-1) internal ribosome entry segment (IRES); Identification of trans-acting factors and cis-acting elements involved in IRES function

Investigating and Targeting the mechanism of HIV-1 protein synthesis.

Recherches sur le plans diagnostic et physiopathologique chez les Virus Emergents

Rol de la replicación extra-hepática del virus de la hepatitis C en la expresión clinica e historia natural de la enfermedad

Review (3)

Investigación y desarrollo de herramientas bioinformáticas para el diseño costo‐efectivo de biosensores y biointerruptores moleculares