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Marcelo Alejandro Navarrete Signorile

Profesor Titular

Universidad de Magallanes

Punta Arenas, Chile

Bioinformatics Lymphoma biology Tumor genetics and immunology

Medicine, ALBERT-LUDWIGS-UNIVERSITAT FREIBURG. Alemania, 2009
Hematology, UNIVERSIDAD DE BUENOS AIRES. Argentina, 2009
Medico, UNIVERSIDAD NACIONAL DE ROSARIO. Chile, 2002

Researcher Full Time

ALBERT-LUDWIGS-UNIVERSITAT FREIBURG

Medicine

Freiburg, Alemania

2006 - 2009
Postdoc Full Time

ALBERT-LUDWIGS-UNIVERSITAT FREIBURG

Medicine

Freiburg, Alemania

2009 - 2011
Researcher Full Time

LEIDEN UNIVERSITY MEDICAL CENTER

Medicine

Leiden, Holanda

2011 - 2013
Professor Full Time

UNIVERSIDAD DE MAGALLANES

Medicine

Punta Arenas, Chile

2013 - A la fecha

Especialista en Formacion Full Time

Hospital General de Agudos Dr. T. Alvarez

Buenos Aires, Argentina

2002 - 2007
Especialista en Hematologia Other

Clinica Red Salud Magallanes

Punta Arenas, Chile

2014 - A la fecha
Coordinador Laboratorio Covid19 Other

CADI UMAG

Punta Arenas, Chile

2020 - A la fecha

Coordinator of the Immunology course at the School of Medicine, University of Magallanes.
PhD Thesis: Florian Scherer, University of Freiburg, Germany
PhD Thesis: Marvyn Koning, Leiden University, The Netherlands
PhD Thesis: Julieta Sepulveda, Leiden University & University of Magallanes
PhD Thesis: Jorge Gonzalez, University of Magallanes

ASH Merit Award

American Society of Hematology

Estados Unidos, 2011

Merit Award in the context of the ASH conference


The role of machine learning in health policies during the COVID-19 pandemic and in long COVID management Varon, Lindybeth Sarmiento; Gonzalez-Puelma, Jorge; Medina-Ortiz, David; Aldridge, Jacqueline; Alvarez-Saravia, Diego; Uribe-Paredes, Roberto; Navarrete, Marcelo A. A. Article ISI FRONTIERS IN PUBLIC HEALTH (2023)
Differential neutralizing antibody responses elicited by CoronaVac and BNT162b2 against SARS-CoV-2 Lambda in Chile Acevedo, Monica L.; Gaete-Argel, Aracelly; Alonso-Palomares, Luis; de Oca, Marco Montes; Bustamante, Andres; Gaggero, Aldo; Paredes, Fabio; Cortes, Claudia P.; Pantano, Sergio; Martinez-Valdebenito, Constanza; Angulo, Jenniffer; Le Corre, Nicole; Ferres, Marcela; Navarrete, Marcelo A.; Valiente-Echeverria, Fernando; Soto-Rifo, Ricardo Article ISI NATURE MICROBIOLOGY (2022)
Generalized Property-Based Encoders and Digital Signal Processing Facilitate Predictive Tasks in Protein Engineering Medina-Ortiz, David; Contreras, Sebastian; Amado-Hinojosa, Juan; Torres-Almonacid, Jorge; Asenjo, Juan A.; Navarrete, Marcelo; Olivera-Nappa, Alvaro Article ISI FRONTIERS IN MOLECULAR BIOSCIENCES (2022)
Tandem Substitutions in Somatic Hypermutation Sepulveda-Yanez, Julieta H.; Alvarez Saravia, Diego; Pilzecker, Bas; van Schouwenburg, Pauline A.; van den Burg, Mirjam; Veelken, Hendrik; Navarrete, Marcelo A.; Jacobs, Heinz; Koning, Marvyn T. Article ISI FRONTIERS IN IMMUNOLOGY (2022)
TGF-β/SMAD Pathway Is Modulated by miR-26b-5p: Another Piece in the Puzzle of Chronic Lymphocytic Leukemia Progression Marquez, Maria Elena; Sernbo, Sandra; Payque, Eugenia; Uria, Rita; Tosar, Juan Pablo; Querol, Juliana; Berca, Catalina; Uriepero, Angimar; Prieto, Daniel; Alvarez-Saravia, Diego; Oliver, Carolina; Irigoin, Victoria; Dos Santos, Gimena; Guillermo, Cecilia; Landoni, Ana Inés; Navarrete, Marcelo A.; Palacios, Florencia; Oppezzo, Pablo Article ISI CANCERS (2022)
AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression Oppezzo, Pablo; Navarrete, Marcelo; Chiorazzi, Nicholas Article ISI FRONTIERS IN ONCOLOGY (2021)
AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms Morande, Pablo Elias; Yan, Xiao-Jie; Sepulveda, Julieta; Seija, Noe; Marquez, Maria Elena; Sotelo, Natalia; Abreu, Cecilia; Crispo, Martina; Fernandez-Grana, Gabriel; Rego, Natalia; Bois, Therence; Methot, Stephen P.; Palacios, Florencia; Remedi, Victoria; Rai, Kanti R.; Buschiazzo, Alejandro; Di Noia, Javier M.; Navarrete, Marcelo A.; Chiorazzi, Nicholas; Oppezzo, Pablo Article ISI BLOOD (2021)
Integration of Mutational Signature Analysis with 3D Chromatin Data Unveils Differential AID-Related Mutagenesis in Indolent Lymphomas Sepulveda-Yanez, Julieta H.; Alvarez-Saravia, Diego; Fernandez-Goycoolea, Jose; Aldridge, Jacqueline; van Bergen, Cornelis A. M.; Posthuma, Ward; Uribe-Paredes, Roberto; Veelken, Hendrik; Navarrete, Marcelo A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike's Dynamics Gonzalez-Puelma, Jorge; Aldridge, Jacqueline; Montes de Oca, Marco; Pinto, Monica; Uribe-Paredes, Roberto; Fernandez-Goycoolea, Jose; Alvarez-Saravia, Diego; Alvarez, Hermy; Encina, Gonzalo; Weitzel, Thomas; Munoz, Rodrigo; Olivera-Nappa, Alvaro; Pantano, Sergio; Navarrete, Marcelo A. Article ISI VIRUSES-BASEL (2021)
Peripheral IgE Repertoires of Healthy Donors Carry Moderate Mutation Loads and Do Not Overlap With Other Isotypes Koning M.T.; Trollmann I.J.M.; Van Bergen C.A.M.; Saravia D.A.; Navarrete, M. A.; Kie?basa S.M.; Veelken H. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL Prieto, D; Seija, N; Uriepero, A; Souto-Padron, T; Oliver, C; Irigoin, V; Guillermo, C; Navarrete, MA; Landoni, AI; Dighiero, G; Gabus, R; Giordano M.; Oppezzo, P Article ISI SCOPUS BRITISH JOURNAL OF HAEMATOLOGY (2018)
Physical and psychosocial development of Mapuche and nonindigenous Chilean toddlers: A modest role of ethnicity Navarrete, M. A.; Silva, J. R.; Van Ijzendoorn M.H.; CÃ¡rcamo R.A. Article ISI SCOPUS Development and Psychopathology (2018)
Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response van Bergen, Cornelis A.M.; van Luxemburg-Heijs, Simone A.P.; de Wreede, Liesbeth C.; Eefting, Matthijs; von dem Borne, Peter A.; van Balen, Peter; Heemskerk, Mirjam H.M.; Mulder, Arend; Claas, Fransiscus H.J.; Navarrete, Marcelo A.; Honders, Wilhelmina M.; Rutten, Caroline E.; Veelken, Hendrik; Jedema, Inge; Halkes, Constantijn J.M.; Griffioen, Marieke; Falkenburg, J.H. Frederik Article ISI SCOPUS JOURNAL OF CLINICAL INVESTIGATION (2017)
The pathogenesis of follicular lymphoma, beyond apoptosis resistance Navarrete, Marcelo A.; Oppezzo, Pablo Article ISI SCOPUS TRANSLATIONAL CANCER RESEARCH (2017)
ARTISAN PCR: rapid identification of full-length immunoglobulin rearrangements without primer binding bias. Koning, Marvyn T; Kie?basa, Szymon M; Boersma, Vesna; Buermans, Henk P J; van der Zeeuw, Sander A J; van Bergen, Cornelis A M; Cleven, Arjen H G; Kluin, Philip M; Griffioen, Marieke; Navarrete, Marcelo A; Veelken, Hendrik Article British journal of haematology (2016)
Isotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutation Scherer, F; Navarrete, MA; Bertinetti-Lapatki, C; Boehm J.; Schmitt-Graeff, A; Veelken H. Article ISI SCOPUS Leukemia & lymphoma. (2016)
Selection patterns of B-cell receptors and the natural history of follicular lymphoma Scherer, Florian; van der Burgt, Marlon; Kie?basa, Szymon M.; Bertinetti-Lapatki, Cristina; D?hren von Minden, Marcus; Mikesch, Kristina; Zirlik, Katja; de Wreede, Liesbeth; Veelken, Hendrik; Navarrete, Marcelo A. Article ISI British Journal of Haematology (2016)
ELISpot and DC-ELISpot Assay to Measure Frequency of Antigen-Specific IFN gamma-Secreting Cells Navarrete, Marcelo A.; Hnasko, R Article ISI NEISSERIA MENINGITIDIS (2015)
Evidence for idiotype-directed immunosurveillance is restricted to follicular lymphoma and attributable to somatic hypermutation. Papaioannou, Dimitrios; Strothmeyer, Anna-Maria; Dühren-von Minden, Marcus; Keppler-Hafkemeyer, Andrea; Zirlik, Katja; Mikesch, Kristina; van Bergen, Cornelis A M; Navarrete, Marcelo A; Veelken, Hendrik Article Haematologica (2015)
Template-switching anchored polymerase chain reaction reliably amplifies functional lambda light chain transcripts of malignant lymphoma. Koning, Marvyn T; Nteleah, Valeri; Veelken, Hendrik; Navarrete, Marcelo A Article Leukemia & lymphoma (2014)
Usage of standardized antigen-presenting cells improves ELISpot performance for complex protein antigens Navarrete, Marcelo A.; Bertinetti-Lapatki, Cristina; Michelfelder, Ines; Veelken, Hendrik Article ISI JOURNAL OF IMMUNOLOGICAL METHODS (2013)
The use of rituximab therapy in patients with acquired factor v inhibitors Navarrete, M. A.; van der Meer, F. J. M.; Damiani, G.; Diaz, A.; Eikenboom, J. Article ISI AMERICAN JOURNAL OF HEMATOLOGY (2012)
Upfront immunization with autologous recombinant idiotype Fab fragment without prior cytoreduction in indolent B-cell lymphoma Navarrete, Marcelo A.; Heining-Mikesch, Kristina; Schueler, Frank; Bertinetti-Lapatki, Cristina; Ihorst, Gabriele; Keppler-Hafkemeyer, Andrea; Doelken, Gottfried; Veelken, Hendrik Article ISI BLOOD (2011)
Comparative analysis of predicted HLA binding of immunoglobulin idiotype sequences indicates T cell-mediated immunosurveillance in follicular lymphoma Strothmeyer, Anna-Maria; Papaioannou, Dimitrios; Duehren-von Minden, Marcus; Navarrete, Marcelo; Zirlik, Katja; Heining-Mikesch, Kristina; Veelken, Hendrik Article ISI BLOOD (2010)
Nosology of Malignant Lymphomas - A Modern Pathobiological Approach Navarrete M, Veelken H. Article American Journal of Blood Research (0)


HIGH-THROUGHPUT ANALYSIS OF FULL-LENGTH IMMUNOGLOBULIN TRANSCRIPTS BY TEMPLATE-SWITCHING ANCHORED PCR AND MASSIVE PARALLEL SEQUENCING ON THE PACBIO PLATFORM Koning, MT; Nteleah, V; Navarrete, MA; Veelken H. Abstract ISI HAEMATOLOGICA (2014)
Massive Parallel Sequencing of Full-Length B-Cell Receptor Sequences Reveals HLA-Dependent Shaping of the B-Cell Immune Repertoire Koning, MT; van der Zeeuw, SAJ; Navarrete, M; van Bergen, CAM; Nteleah, V; Griffioen, M; Kielbasa, SM; Veelken H. Abstract ISI BLOOD (2014)


Identification of Immunoglobulin Gene Usage in Immune Repertoires Sequenced by Nanopore Technology Ahumada-García R.; González-Puelma J.; Álvarez-Saravia D.; Barrientos R.J.; Uribe-Paredes R.; López-Cortés X.A.; Navarrete, M. A. ConferencePaper ISI SCOPUS LEARNING AND INTELLIGENT OPTIMIZATION, LION 15 (2019)


ARTISAN PCR: rapid identification of full-length immunoglobulin rearrangements without primer binding bias Koning M.T.; Kie?basa S.M.; Boersma V.; Buermans H.P.J.; van der Zeeuw S.A.J.; van Bergen C.A.M.; Cleven A.H.G.; Kluin P.M.; Griffioen M.; Navarrete M.A.; Veelken H. Letter ISI SCOPUS BRITISH JOURNAL OF HAEMATOLOGY (2017)
Evidence for idiotype-directed immunosurveillance is restricted to follicular lymphoma and attributable to somatic hypermutation Papaioannou, D; Strothmeyer, AM; Duhren-von Minden, M; Keppler-Hafkemeyer, A; Zirlik, K; Mikesch, K; van Bergen, CAM; Navarrete, MA; Veelken H. Letter ISI SCOPUS Haematologica (2015)
Template-switching anchored polymerase chain reaction reliably amplifies functional lambda light chain transcripts of malignant lymphoma Koning, MT; Nteleah, V; Veelken H.; Navarrete, MA Letter ISI SCOPUS Leukemia & lymphoma. (2014)


Caracterización funcional de mutaciones con potencial oncogénico inducidas por la enzima AID durante la progresión leucemica Oppezzo, P; Navarrete, M Proyecto (2022)
Computational Oncology: Follicular lymphoma as a model for multidimensional analysis of tumor heterogeneity and subclonal evolution Navarrete, Marcelo; Van Bergen C.A.M. Proyecto (2021)
Tratamiento con Plasma Hiperinmune para Pacientes Críticos con COVID-19 Navarrete, Marcelo A.; Navarrete, Marcelo A.; Rodrigo Muñoz; Monica Pinto A Proyecto (2020)
Assessment of AID-related somatic signatures and their role in tumor progression of class switched vs non-switched B-cell neoplasms Marcelo A Navarrete; Cerda, Mauricio Proyecto (2018)
Oncogenic B-Cell Receptor Signalling in Aggressive B-Cell Lymphomas KWF - The Netherlands (10208) Proyecto 2017-2021 Coinvestigador(a)
ANALYSIS OF IMMUNOGLOBULIN-DERIVED EPITOPES DIVERSIFICATION FOR IMPROVING IDIOTYPE VACCINATION STRATEGIES FONDECYT (11140542) Proyecto 2014-2017 Inv. Responsable
Developing an European American Next Generation Sequencing Network (DEANN) European Commission (http=>//bioinfo.cipf.es/deann/?page_id=36) Proyecto 2014-2017 Coinvestigador(a)
DEVELOPMENT OF A NOVEL TOOL FOR B-CELL RECEPTOR SELECTION PATTERN ANALYSIS IN INDOLENT NON-HODGKIN LYMPHOMAS Universidad de Magallanes (018/DIP-14) Proyecto 2014-2014 Inv. Principal
High-throughput sequencing of the B-cell repertoire. Leiden Genome Technology Center (SASC2013#7) Proyecto 2013-2014 Inv. Principal
RED-IBEROAMERICANA DE LEUCEMIA LINFOIDE CRÓNICA=> HACIA EL DESARROLLO DE NUEVOS MARCADORES PRONÓSTICOS. CYTED (212RT0455) Proyecto 2012-2016 Investigador(a)
Role of B-Cell Receptor in Lymphoma Immunobiology Leiden University Medical Center (VBR 80306) Proyecto 2011-2015 Coinvestigador(a)
Immunotherapy of B-cell Lymphomas DEUTSCHE KREBSHILFE (70-2698-Ve I) Proyecto 2006-2011 Postdoctorado


Mortality in Critically Ill Elderly Individuals Receiving Mechanical Ventilation Santa Cruz R.; Villarejo F.; Figueroa A.; CortÃ©s-JofrÃ© M.; Gagliardi J.; Navarrete M. Review ISI SCOPUS Respiratory Care (2019)