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Mauricio Vargas Uribe

Head of R&D

Kura Biotech

Puerto Varas, Chile

Biotechnology; Protein Folding and Stability; Proteomics; Enzymology; Membrane Proteins; Lipids, Thermodynamics

PhD Biochemistry and Molecular Biology, UNIVERSITY OF KANSAS-MEDICAL CENTER. Estados Unidos, 2015
Biochemistry, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007
Biochemist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007

Research Assistant Part Time

UNIVERSITY OF KANSAS-MEDICAL CENTER

2010 - 2015
Adjunt Professor Part Time

UNIVERSIDAD AUSTRAL DE CHILE

Ciencias

Valdivia, Chile

2015 - 2018

Research Assistant Part Time

University of Kansas-Medical Center

Kansas City, Estados Unidos

2010 - 2015
Adjunt Professor Part Time

Universidad Austral de Chile

Valdivia, Chile

2015 - 2018
Head of R&D Proteomics and Toxicology Full Time

Kura Biotech

Puerto Varas, Chile

2019 - A la fecha


Conformational Switching in Bcl-xL: Enabling Non-Canonic Inhibition of Apoptosis Involves Multiple Intermediates and Lipid Interactions Vasquez-Montes, Victor; Kyrychenko, Alexander; Vargas-Uribe, Mauricio; Rodnin, Mykola, V; Ladokhin, Alexey S. Article ISI CELLS (2020)
Lipid-modulation of membrane insertion and refolding of the apoptotic inhibitor Bcl-xL Vasquez-Montes, V; Vargas-Uribe, M; Pandey, NK; Rodnin, MV; Langen, R; Ladokhin, AS Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2019)
Cellular Entry of the Diphtheria Toxin Does Not Require the Formation of the Open-Channel State by Its Translocation Domain Ladokhin, Alexey S.; Vargas-Uribe, Mauricio; Rodnin, Mykola V.; Ghatak, Chiranjib; Sharma, Onkar Article ISI TOXINS (2017)
Effect of nordihydroguaiaretic acid on cell viability and glucose transport in human leukemic cell lines Leon, David; Parada, Daniela; Vargas-Uribe, Mauricio; Perez, Alejandra A.; Ojeda, Lorena; Zambrano, Angara; Reyes, Alejandro M.; Salas, Mónica Article ISI FEBS Open Bio (2016)
Membrane Association of the Diphtheria Toxin Translocation Domain Studied by Coarse-Grained Simulations and Experiment Flores-Canales, Jose C.; Vargas-Uribe, Mauricio; Ladokhin, Alexey S.; Kurnikova, Maria Article ISI JOURNAL OF MEMBRANE BIOLOGY (2015)
Role of Acidic Residues in Helices TH8-TH9 in Membrane Interactions of the Diphtheria Toxin T Domain Ghatak, Chiranjib; Rodnin, Mykola V.; Vargas-Uribe, Mauricio; McCluskey, Andrew J.; Flores-Canales, Jose C.; Kurnikova, Maria; Ladokhin, Alexey S. Article ISI TOXINS (2015)
Thermodynamics of Membrane Insertion and Refolding of the Diphtheria Toxin T-Domain Vargas-Uribe, Mauricio; Rodnin, Mykola V.; Ojemalm, Karin; Holgado, Aurora; Kyrychenko, Alexander; Nilsson, IngMarie; Posokhov, Yevgen O.; Makhatadze, George; von Heijne, Gunnar; Ladokhin, Alexey S. Article ISI JOURNAL OF MEMBRANE BIOLOGY (2015)
Comparison of Membrane Insertion Pathways of the Apoptotic Regulator Bcl-xL and the Diphtheria Toxin Translocation Domain Vargas-Uribe, Mauricio; Rodnin, Mykola V.; Ladokhin, Alexey S. Article ISI BIOCHEMISTRY (2013)
Crucial Role of H322 in Folding of the Diphtheria Toxin T-Domain into the Open-Channel State Vargas-Uribe, Mauricio; Rodnin, Mykola V.; Kienker, Paul; Finkelstein, Alan; Ladokhin, Alexey S. Article ISI BIOCHEMISTRY (2013)
pH-Triggered Conformational Switching of the Diphtheria Toxin T-Domain: The Roles of N-Terminal Histidines Kurnikov, Igor V.; Kyrychenko, Alexander; Flores-Canales, Jose C.; Rodnin, Mykola V.; Simakov, Nikolay; Vargas-Uribe, Mauricio; Posokhov, Yevgen O.; Kurnikova, Maria; Ladokhin, Alexey S. Article ISI JOURNAL OF MOLECULAR BIOLOGY (2013)
Resolution of the direct interaction with and inhibition of the human GLUT1 hexose transporter by resveratrol from its effect on glucose accumulation Salas, M; Obando, P; Ojeda L.; Ojeda P.; Pérez, A.; Vargas-Uribe, M; Rivas, CI; Vera, JC; Reyes, AM Article ISI SCOPUS American Journal of Physiology - Cell Physiology (2013)
Folding of diphtheria toxin T-domain in the presence of amphipols and fluorinated surfactants: Toward thermodynamic measurements of membrane protein folding Kyrychenko, Alexander; Rodnin, Mykola V.; Vargas-Uribe, Mauricio; Sharma, Shivaji K.; Durand, Gregory; Pucci, Bernard; Popot, Jean-Luc; Ladokhin, Alexey S. Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2012)
Noncompetitive blocking of human GLUT1 hexose transporter by methylxanthines reveals an exofacial regulatory binding site Ojeda P.; Pérez, A.; Ojeda L.; Vargas-Uribe, M; Rivas C.I.; Salas, M; Vera, J. C.; Reyes, A.M. Article ISI SCOPUS American Journal of Physiology - Cell Physiology (2012)
Replacement of C-Terminal Histidines Uncouples Membrane Insertion and Translocation in Diphtheria Toxin T-Domain Rodnin, Mykola V.; Kyrychenko, Alexander; Kienker, Paul; Sharma, Onkar; Vargas-Uribe, Mauricio; Collier, R. John; Finkelstein, Alan; Ladokhin, Alexey S. Article ISI BIOPHYSICAL JOURNAL (2011)


Fluorescence Applications for Structural and Thermodynamic Studies of Membrane Protein Insertion Kyrychenko, A; Posokhov, YO; Vargas-Uribe, M; Ghatak, C; Rodnin, MV; Ladokhin, AS; Geddes, CD BookSection (2017)


EFFECT OF LIPIDS IN THE STRUCTURAL REARRANGEMENT OF THE GLUCOSE TRANSPORTER GLUT1 UPON GLUCOSE BINDING FONDECYT (3160734) Proyecto 2016-2018 Inv. Responsable
Modulation of membrane interactions of the apototic repressor Bcl-xL by lipids Biomedical Research Training Program KUMC (BRTP 2014-2015) Proyecto 2014-2015 Investigador(a)
Beca de Doctorado Igualdad de Oportunidades FULBRIGHT-CONICYT FULBRIGHT-CONICYT (IIE ID 15102782) Proyecto 2010-2014 Investigador(a)

Mauricio Vargas

Head of R&D

R&D

Kura Biotech

Puerto Varas, Chile

Paola Ojeda

Profesor Adjunto

Ciencias Pre-clinicas

Universidad Católica del Maule

Talca, Chile

CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

Alejandro Reyes

Profesor Titular

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

Angara Zambrano

Assistant Professor

Biochemistry and Microbiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Mauricio Vargas Uribe

Líneas de Investigación

Educación

PhD Biochemistry and Molecular Biology, UNIVERSITY OF KANSAS-MEDICAL CENTER. Estados Unidos, 2015

Biochemistry, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007

Biochemist, UNIVERSIDAD AUSTRAL DE CHILE. Chile, 2007

Experiencia Académica

Research Assistant Part Time

Adjunt Professor Part Time

Experiencia Profesional

Research Assistant Part Time

Adjunt Professor Part Time

Head of R&D Proteomics and Toxicology Full Time

Article (14)

Conformational Switching in Bcl-xL: Enabling Non-Canonic Inhibition of Apoptosis Involves Multiple Intermediates and Lipid Interactions

Lipid-modulation of membrane insertion and refolding of the apoptotic inhibitor Bcl-xL

Cellular Entry of the Diphtheria Toxin Does Not Require the Formation of the Open-Channel State by Its Translocation Domain

Effect of nordihydroguaiaretic acid on cell viability and glucose transport in human leukemic cell lines

Membrane Association of the Diphtheria Toxin Translocation Domain Studied by Coarse-Grained Simulations and Experiment

Role of Acidic Residues in Helices TH8-TH9 in Membrane Interactions of the Diphtheria Toxin T Domain

Thermodynamics of Membrane Insertion and Refolding of the Diphtheria Toxin T-Domain

Comparison of Membrane Insertion Pathways of the Apoptotic Regulator Bcl-xL and the Diphtheria Toxin Translocation Domain

Crucial Role of H322 in Folding of the Diphtheria Toxin T-Domain into the Open-Channel State

pH-Triggered Conformational Switching of the Diphtheria Toxin T-Domain: The Roles of N-Terminal Histidines

Resolution of the direct interaction with and inhibition of the human GLUT1 hexose transporter by resveratrol from its effect on glucose accumulation

Folding of diphtheria toxin T-domain in the presence of amphipols and fluorinated surfactants: Toward thermodynamic measurements of membrane protein folding

Noncompetitive blocking of human GLUT1 hexose transporter by methylxanthines reveals an exofacial regulatory binding site

Replacement of C-Terminal Histidines Uncouples Membrane Insertion and Translocation in Diphtheria Toxin T-Domain

BookSection (1)

Fluorescence Applications for Structural and Thermodynamic Studies of Membrane Protein Insertion

Proyecto (3)

EFFECT OF LIPIDS IN THE STRUCTURAL REARRANGEMENT OF THE GLUCOSE TRANSPORTER GLUT1 UPON GLUCOSE BINDING