In vitro antibacterial activity of the peptide PsVP-10 against antimicrobial-resistant Enterococcus faecalis isolated from clinical samples

Padilla, C; Lobos O.; Brevis, P; Abaca, P; Hubert E.

Abstract

Objective: To analyse the antimicrobial activity of the peptide PsVP-10 against 67 resistant Enterococcus faecalis strains isolated from clinical samples. Methods: The qualitative disc diffusion method and MIC determinations were used. Results: The presence of several multidrug-resistant phenotypes of E. faecalis was demonstrated, in which there were high MICs to chloramphenicol, tetracycline, vancomycin, cefaloridine, ampicillin and gentamicin. In comparison, the peptide PsVP-10 showed lower MICs against all the multidrug-resistant and susceptible E. faecalis. Conclusions: There is an urgent need for the development of novel antimicrobial agents against the highly resistant E. faecalis. The present study shows that the peptide PsVP-10 might make a contribution to the solution of this serious problem.

Más información

Título según WOS: In vitro antibacterial activity of the peptide PsVP-10 against antimicrobial-resistant Enterococcus faecalis isolated from clinical samples
Título según SCOPUS: In vitro antibacterial activity of the peptide PsVP-10 against antimicrobial-resistant Enterococcus faecalis isolated from clinical samples
Título de la Revista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volumen: 53
Número: 2
Editorial: OXFORD UNIV PRESS
Fecha de publicación: 2004
Página de inicio: 390
Página final: 392
Idioma: English
URL: http://www.jac.oupjournals.org/cgi/doi/10.1093/jac/dkh067
DOI:

10.1093/jac/dkh067

Notas: ISI, SCOPUS