Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes

Maya, JD; Morello A.; Repetto Y; Tellez, R; Rodríguez A.; Zelada, U; Puebla P.; Caballero, E; Medarde, M; Nunez-Vergara, LJ; Squella, JA; Bonta, M; Bollo, S; San Feliciano A.

Abstract

A series of 3-chloro-phenyl-1,4-dihydropyridine derivatives produced different degrees of inhibition of parasite growth and respiration on clone Brener, LQ and Tulahuen strains of Trypanosome cruzi epimastigotes. Respiratory chain inhibition appears to be a posible determinant of the trypanosomicidal activity of this compounds. No difference in the action of these derivatives was found among the different parasite strains. For comparative purposes, the inhibitory effects of felodipine and nicardipine are also reported. A good correlation between toxic effects and the easiness of oxidation of the dihydripyridine ring was found. The presence of a fused ring on the dihydropyridine moiety significantly diminished the inhibitory effects. (C) 2000 Elsevier Science Inc. All rights reserved.

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Título según WOS: Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes
Título según SCOPUS: Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes
Título de la Revista: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY ENDOCRINOLOGY
Volumen: 125
Número: 1
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2000
Página de inicio: 103
Página final: 109
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0742841399000961
DOI:

10.1016/S0742-8413(99)00096-1

Notas: ISI, SCOPUS