Medicinal Plants of Chile: Evaluation of their Anti-Trypanosoma cruzi Activity

Munoz, OM; Maya, JD; Ferreira J.; Christen P.; San Martin, J; Lopez-Munoz, R; Morello A.; Kemmerling U.

Abstract

The extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and Drimys winteri. The active extract of Drimys winteri (IC50 51.2 mu g/mL) was purified and three drimane sesquiterpenes were obtained: polygodial, drimenol, and isodrimenin. Isodrimenin and drimenol were found to be active against the trypomastigote form of T cruzi with IC50 values of 27.9 and 25.1 mu M, respectively.

Más información

Título según WOS: Medicinal Plants of Chile: Evaluation of their Anti-Trypanosoma cruzi Activity
Título de la Revista: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
Volumen: 68
Número: 05-jun
Editorial: WALTER DE GRUYTER GMBH
Fecha de publicación: 2013
Página de inicio: 198
Página final: 202
Idioma: English
Notas: ISI