Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels

Orellana, J.A.; Schalper K.A.; Figueroa, V.; Sanchez H.A.; Sáez, J.C.


The synchronization of numerous cellular events requires complex electric and metabolic cell-cell interactions. Connexins are a family of membrane proteins that constitute the molecular basis of two kinds of channels: gap junction channels (GJCs), which allow direct cytoplasm-cytoplasm communication, and hemichannels (HCs) that provide a pathway for exchanges between the intra and extra-cellular milieu. Both kind of connexin-based channels support intercellular communication via intercellular propagation of calcium waves. Here, we review evidence supporting the role of Ca 2+ in the regulation of GJCs and HCs formed by connexins. Also it is speculated how these connexin-based channels could contribute to the propagation of intercellular Ca 2+ signals. © 2012 Springer Science+Business Media B.V.

Más información

Título de la Revista: Advances in Experimental Medicine and Biology
Volumen: 740
Editorial: Springer, Cham
Fecha de publicación: 2012-01-01
Página de inicio: 777
Página final: 794
Idioma: English


Identificador: 10.1007/978-94-007-2888-2_34