Atrofia vellositaria duodenal inducida por micofenolato mofetil: Caso clínico

Tapia E, Oscar; Villaseca H, Miguel; SIERRALTA Z, ARMANDO; Roa S, Juan Carlos

Keywords: diarrhea, mycophenolate mofetil, immunosuppressive agents

Abstract

Mycophenolate mofetil (MMF) is an immunosupressor agent frequently used in patients after bone marrow or solid organ transplants. The most common adverse reactions of the drug are gastrointestinal, specially diarrhea and vomiting. We report a 53-year-old male, that received a heart transplant receiving immunosuppression with cyclosporine, mycophenolate mofetil and prednisone. Six months after the transplant, the patient started with diarrhea, anorexia and weight loss. A duodenal biopsy showed villous atrophy. Celiac disease and the presence of parasites were discarded. Mycophenolate mofetil was discontinued and one week later, diarrhea subsided. Two months later the patient was asymptomatic and recovered weight. A new duodenal biopsy showed absence of villous atrophy.

Más información

Título según SCIELO: Atrofia vellositaria duodenal inducida por micofenolato mofetil: Caso clínico
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 138
Número: 5
Editorial: SOC MEDICA SANTIAGO
Fecha de publicación: 2010
Página de inicio: 590
Página final: 594
Idioma: es
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000500010&lng=en&nrm=iso&tlng=en
DOI:

10.4067/S0034-98872010000500010

Notas: SCIELO