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Wendy Gonzalez Diaz

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Líneas de Investigación


Biophysics of potassium channels; Bioinformatics and Molecular Simulations; Molecular Modeling; Protein-ligand interactions

Educación

  •  PhD in Sciences, Mention Plant Genetic Engineering, UNIVERSIDAD DE TALCA. Chile, 2010
  •  Biologist, UNIVERSIDAD DE LA HABANA. Cuba, 2003
  •  Specialist in Bioinformatics, Centro de Ingeniería Genética y Biotecnología (CIGB). Cuba, 2003

Experiencia Académica

  •   Teacher Full Time

    UNIVERSIDAD DE TALCA

    Ingeniería

    Chile

    Enero 2010 - Enero 2011

  •   Assistant Professor Full Time

    UNIVERSIDAD DE TALCA

    Ingeniería

    Chile

    Enero 2012 - Enero 2014

  •   Associate Professor Full Time

    UNIVERSIDAD DE TALCA

    Ingeniería

    Chile

    Enero 2014 - A la fecha

Experiencia Profesional

  •   Research Assistant Full Time

    Centro Nacional de Bioinformática (BIOINFO)/Ministerio de Ciencia, Tecnología y Medio Ambiente

    Cuba

    Enero 2003 - Enero 2004

  •   Research Assistant Full Time

    Centro de Estudios Científicos (CECs)

    Chile

    Enero 2004 - Enero 2004

  •   Research Assistant Full Time

    Universidad de Talca

    Chile

    Enero 2004 - Enero 2010

  •   Researcher Full Time

    CBSM/Utalca

    Chile

    Enero 2010 - Enero 2012

  •   Director of the Center for Bioinformatics and Molecular Simulations (CBSM) Full Time

    CBSM/Utalca

    Talca, Chile

    Enero 2012 - A la fecha

Formación de Capital Humano


Director of PhD. thesis: 3 in the last five years
Co-director of PhD. thesis: 1 in the last five years
Director of current PhD. thesis: 3 in the framework of the Fondecyt 1140624 and 1191133 Grants

Co-director of undergraduate thesis: 1
Director of undergraduate thesis: 3 in the last five years
Director of current undergraduate thesis: 1 in the framework of the Millennium Nucleus Minicad


Difusión y Transferencia


Dissemination: Every year I meet with secondary school students to motivate them to study Bioinformatics Engineering at University of Talca. I perform every year one talk of about 1 hour to this audience.
Transfer: One patent application


Premios y Distinciones

  •   Fellowship for PhD. studies

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2006

    To perform graduate studies

  •   Beca de Apoyo a la Realización de Tesis Doctoral # AT24071103

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2007

    Beca de Apoyo a la Realización de Tesis Doctoral

  •   Fellowship for an international intership

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2008

    For a research stay at the University of Potsdam, Germany

  •   Fellowship to finish PhD. thesis

    CONSEJO NACIONAL DE CIENCIA Y TECNOLOGIA

    Chile, 2009

    Beca de Término de Tesis Doctoral

  •   Postdoctoral Fellowship

    DEUTSCHE FORSCHUNGSGEMEINSCHAFT

    Alemania, 2011

    For a postdoctoral research at University of Potsdam, Germany

  •   Young Scientist Fellowship

    DESCONOCIDO

    Reino Unido, 2012

    Beca para participar en el 37 congreso de la Federación Europea de Sociedades de Bioquímica (FEBS) y el segundo congreso de la Unión Internacional de Bioquímica y Biología Molecular (IUBMB), Programa Científicos Jóvenes

  •   Fellowship from Red Iberoamericana de Bioinformática

    DESCONOCIDO

    Brasil, 2003

    For a research stay at "Instituto de Biofísica de la Universidad Federal de Río de Janeiro"


Tipos de Producción
 

Article (33)

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels
Chalcone derivatives as non-canonical ligands of TRPV1
Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation
Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-PoreDomain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site
Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine
The molecular basis for an allosteric inhibition of K+-flux gating in K-2P channels
Computational Studies of Snake Venom Toxins
Folding and Lipid Composition Determine Membrane Interaction of the Disordered Protein COR15A
Cloning and functional characterization of HKT1 and AKT1 genes of Fragaria spp.-Relationship to plant response to salt stress
Commandeering Channel Voltage Sensors for Secretion, Cell Turgor, and Volume Control
Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A(2), ApITx-I, purified from Agkistrodon piscivorus leucostoma snake venom
Side Fenestrations Provide an "Anchor" for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels
Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia
CoaTx-II, a new dimeric Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom with bactericidal potential: Insights into its structure and biological roles
Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels
Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness
Gating, Regulation, and Structure in K2P K+ Channels: In Varietate Concordia?
Molecular dynamics simulations and CD spectroscopy reveal hydration-induced unfolding of the intrinsically disordered LEA proteins COR15A and COR15B from Arabidopsis thaliana
Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?
Mutation Update of the CLCN5 Gene Responsible for Dent Disease 1
Outward Rectification of Voltage-Gated K+ Channels Evolved at Least Twice in Life History
Voltage-Sensor Transitions of the Inward-Rectifying K+ Channel KAT1 Indicate a Latching Mechanism Biased by Hydration within the Voltage Sensor
An Extracellular Ion Pathway Plays a Central Role in the Cooperative Gating of a K-2P K+ Channel by Extracellular pH
The pH sensor of the plant K+-uptake channel KAT1 is built from a sensory cloud rather than from single key amino acids
Potassium (K plus ) gradients serve as a mobile energy source in plant vascular tissues
The K + battery-regulating Arabidopsis K + channel AKT2 is under the control of multiple post-translational steps
A Minimal Cysteine Motif Required to Activate the SKOR K+ Channel of Arabidopsis by the Reactive Oxygen Species H2O2
Distributed Structures Underlie Gating Differences between the K-in Channel KAT1 and the K-out Channel SKOR
Distinct roles of the last transmembrane domain in controlling Arabidopsis K+ channel activity
Intrinsic electrostatic potential in the BK channel pore: Role in determining single channel conductance and block
Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel
Gating of two-pore domain K+ channels by extracellular pH
Effect of high concentration of Co (II) onEnterobacter liquefaciens strain C-1: A bacterium highly resistant to heavy metals with an unknown genome.

Grant (19)

Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD)
Molecular modelling of LEA proteins (Redes Conicyt 120019)
Voltage Sensor of Ion Channels: From Structure to Function (Anillo ACT1104)

Abstract (7)

Proton Permeation in Ci-Hv1 Voltage-Gated Proton Channels occurs through a Proton Wire Involving Residues D160 and D222 and It is Modulated by N264
The pH sensor of the plant K plus uptake channel KAT1 is built from a sensory cloud rather than from single key amino acids
Dissecting phosphatidylinositol 4,5-bisphosphate activation and thermosensation in TRP channels
External surface charge neutralization induces outward rectification on the calcium- and voltage-activated potassium channel BK
Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel.
Exploring the Shaker K+ channel S3b segment using deletion mutants.
Role of the electrostatic potential on the BK potassium channel conductance.

Review (4)

Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (Ca-V) Channels
K-2P channels in plants and animals
TASK-2: a K-2p K+ channel with complex regulation and diverse physiological functions
ClC-5 mutations associated with Dent's disease: a major role of the dimer interface

Patent (1)

COMPUESTOS INHIBIDORES DE CANALES DE POTASIO DE TIPO TASK (Solicitud de patente 201701280)

Nil Class (0)

64
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

11
Fernando González

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

10
Ingo Dreyer

Professor Titular

Bioinformatica

Universidad de Talca

Talca, Chile

8
Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

8
David Ramirez

Profesor Asistente

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Talca, Chile

5
Luis Cid

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

5
leandro zuniga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

5
Maria Niemeyer

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECS

Valdivia, Chile

3
Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

3
Julio Caballero

head of department of Bioinformatics

Departamento de Ciencias Aplicadas

Universidad de Talca

Talca, Chile

1
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Vania Figueroa

Profesor Asistente

Instituto de Ciencias de la Salud

Universidad de O’Higgins

Rancagua, Chile

1
Karen Castillo

Investigadora Joven

Laboratorio de Sensores Moleculares, Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso

Valparaiso, Chile

1
Mauricio Retamal

Profesor Asociado

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

1
Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

1
Paola Ojeda

Profesor

Ciencias de la Salud

Universidad Autonóma de Chile

Talca, Chile

1
Jimmy Stehberg

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile