Man

Claudia Paz Saavedra Sanchez

Full Professor

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

Líneas de Investigación


Structural and functional studies of Salmonella Typhimurium Porins; Structural and biochemical studies of enzymes; Molecular resistance strategies to adverse conditions present in extreme environments

Educación

  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2002
  •  Biochemist, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 1989
  •  Masters in Biological Sciences with mention in Molecular and Cellular Biology, UNIVERSIDAD DE CHILE. Chile, 1997
  •  Post-PhD Research, TEXAS A&M UNIVERSITY. Estados Unidos, 2003

Experiencia Académica

  •   Postdoctoral student Full Time

    TEXAS A&M UNIVERSITY

    Biology

    College Station, Texas, Estados Unidos

    Enero 2002 - Enero 2003

  •   Assistant professor Part Time

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Faculty of chemistry and biology

    Santiago, Chile

    Enero 1995 - Enero 2003

  •   assistant professor Full Time

    UNIVERSIDAD ANDRES BELLO

    Faculty of Biological Sciences

    Santiago, Chile

    Enero 2005 - Enero 2014

  •   Full professor Full Time

    UNIVERSIDAD ANDRES BELLO

    Santiago, Chile

    Enero 2015 - A la fecha

Experiencia Profesional

  •   Assistant professor Full Time

    Universidad de Talca

    Talca, Chile

    Enero 1989 - Enero 1995

  •   Associate professor Part Time

    Universidad de Santiago

    Santiago, Chile

    Enero 1995 - Enero 2004

  •   Biochemistry School Director Full Time

    Universidad Andrés Bello

    Santiago, Chile

    Enero 2005 - A la fecha

  •   Academic microbiology area Part Time

    Inacap

    Santiago, Chile

    Enero 1995 - Enero 2004

Formación de Capital Humano


Fernando Olate; U. Chile / UNAB-Biochemistry; Sponsor; 2009.
Andrea Lorenzi; U. Chile / UNAB-Biochemistry; Sponsor; 2009.
Patricia Muñoz; U. Chile / UNAB-Biochemistry; Sponsor; 2009.
Miriam Barros; U. Chile / UNAB-Biochemistry; Sponsor; 2009.
Nataly Contreras; U. Chile / UNAB-Biochemistry; Sponsor; 2009.
Carolina Leal; U. Chile / UNAB-Biochemistry; Sponsor; 2009.
Mauricio Valdivia; USACH / UNAB-Biochemistry; Sponsor; 2010.
Juan Pablo Monras; USACH / UNAB-Biochemistry; Sponsor; 2010.
Cristian Sabotier; USACH / UNAB-Biochemistry; Sponsor; 2010.

Catalina Chahuán; UNAB / Biochemistry – Master in Biochemistry; Tutor of Undergraduate Research Unit; 2008-2009.
Debbie Monsalva; UNAB / Biochemistry – Master in Biochemistry; Tutor of Undergraduate Research Unit; 2010.
Samuel Parra; UNAB / Biochemistry – Master in Biochemistry; Tutor of Undergraduate Research Unit; 2009-2010.
Patricio Guerrero; UNAB / Biochemistry – Master in Biochemistry; Tutor of Undergraduate Research Unit; 2010-2011.
Carolina Cabezas; UNAB / Biochemistry – Master in Biochemistry; Tutor of Undergraduate Research Unit; 2012.
Paulina Calderón; UNAB / Biochemistry – Master in Biochemistry; Tutor of Undergraduate Research Unit; 2012.
Ricardo Álvarez; UNAB / Biochemistry – Master in Biochemistry; Tutor of Undergraduate Research Unit; 2012.
Roberto Luraschi; UNAB / Biochemistry – Master in Biochemistry; Tutor of Undergraduate Research Unit; 2013.
Alan Briones; UNAB / Biochemistry – Master in Biochemistry; Tutor of Undergraduate Research Unit; 2013-2014.
Ana Inostroza; UNAB / Biochemistry – Master in Biochemistry; Tutor of Undergraduate Research Unit; 2013-2014.
Sylvana Urra; UNAB / Biochemistry – Master in Biochemistry; Tutor of Undergraduate Research Unit; 2013-2014.
Cesar Salinas; UNAB / Biochemistry – Master in Biochemistry; Tutor of Undergraduate Research Unit; 2015-2016.

María Graciela Delgado; Master in Biochemistry/UNAB; Masters thesis tutor; 2009.
Juan Ignacio Gutiérrez; Master in Biochemistry/UNAB; Masters thesis tutor; 2009.
Nelson Caro; Master in Biochemistry/UNAB; Masters thesis tutor; 2009.
Bernardo Collao; Master in Biochemistry/UNAB; Masters thesis tutor; 2010.
Catalina Chahuán; Master in Biochemistry/UNAB; Masters thesis tutor; 2010.
Samuel Parra; Master in Biochemistry/UNAB; Masters thesis tutor; 2011.
Nicolás Pacheco; Master in Biochemistry/UNAB; Masters thesis tutor; 2012.
Debbie Monsalva; Master in Biochemistry/UNAB; Masters thesis tutor; 2012.
Marlen Espinoza; Master in Biochemistry/UNAB; Masters thesis tutor; 2013-2014.
Roberto Luraschi; Master in Biochemistry/UNAB; Masters thesis tutor; 2013-2014.
Carolina Cabezas; Master in Biochemistry/UNAB; Masters thesis tutor; 2014.
Alan Briones; Master in Biochemistry/UNAB; Masters thesis tutor; 2014.
Ana Inostroza; Master in Biochemistry/UNAB; Masters thesis tutor; 2014.
Sylvana Urra; Master in Biochemistry/UNAB; Masters thesis tutor; 2014.
Cesar Salinas; Master in Biochemistry/UNAB; Masters thesis tutor; 2016.
Camila Aguirre; Master in Biochemistry/UNAB; Masters thesis tutor; 2017.

Fernando Gil Michell; Molecular Biosciences PhD program/UNAB; Thesis tutor; 2010.
José Miguel Villarreal; Biotechnology PhD program/UNAB; Thesis tutor; 2010.
Francisco Ipinza; Biotechnology PhD program/UNAB; Thesis tutor; 2012.
Eduardo Morales; Molecular Biosciences PhD program/UNAB; Thesis tutor; 2013
Bernardo Collao; Molecular Biosciences PhD program/UNAB; Thesis tutor; 2014.

Mario Navarrete; Molecular Biosciences PhD program/UNAB; Member of the evaluation committee preliminary draft thesis ; 2010.
Matías Jofre; Molecular Biosciences PhD program/UNAB; Member of the evaluation committee preliminary draft thesis ; 2011.
Cristóbal Mujica; Biotechnology PhD program/UNAB; Member of the evaluation committee preliminary draft thesis ; 2011.
Annettte Nicole Trombert; Molecular Biosciences PhD program/UNAB; Member of the evaluation committee preliminary draft thesis ; 2011.
Hugo González; Molecular Biosciences PhD program/UNAB; Member of the evaluation committee preliminary draft thesis ; 2011.
Héctor Osorio; Molecular Biosciences PhD program/UNAB; Member of the evaluation committee preliminary draft thesis ; 2012.
Daniela Doñas; Molecular Biosciences PhD program/UNAB; Member of the evaluation committee preliminary draft thesis ; 2012.
Nicolás Villagra; Molecular Biosciences PhD program/UNAB; Member of the evaluation committee preliminary draft thesis ; 2012.

María Graciela Delgado; Master in Biochemistry/UNAB; President of examination committee degree; 2009.
Juan Ignacio Gutiérrez; Master in Biochemistry/UNAB; President of examination committee degree; 2009.
Simón Vidal; Master in Biochemistry/UNAB; Degree examination committee member; 2009.
Bernardo Collao; Master in Biochemistry/UNAB; President of examination committee degree; 2009.
Carlos Rosales; Master in Biochemistry/UNAB; Degree examination committee member; 2009.

Cristobal Mujica; Molecular Biosciences PhD program/UNAB; President qualifying examination committee; 2009.
Héctor Osorio; Molecular Biosciences PhD program/UNAB; Qualifying examination committee member; 2010.
Matias Jofré; Molecular Biosciences PhD program/UNAB; Qualifying examination committee member; 2010.
Annette Nicole Trombert; Molecular Biosciences PhD program/UNAB; Qualifying examination committee member; 2011.
Daniela Doñas; Molecular Biosciences PhD program/UNAB; Qualifying examination committee member; 2013.
César Echeverría; Molecular Biosciences PhD program/UNAB; Qualifying examination committee member; 2013.
Nicolás Villagra; Molecular Biosciences PhD program/UNAB; Qualifying examination committee member; 2014.

Bernardo Collao; Molecular Biosciences PhD program/UNAB; Research unit Tutor; 2010.
Eduardo Morales; Molecular Biosciences PhD program/UNAB; Research unit Tutor; 2010.



 

Article (24)

Arsenic Response of Three Altiplanic Exiguobacterium Strains With Different Tolerance Levels Against the Metalloid Species: A Proteomics Study
Cysteine auxotrophy drives reduced susceptibility to quinolones and paraquat by inducing the expression of efflux-pump systems and detoxifying enzymes in S. Typhimurium.
The Transcription Factor ArcA Modulates Salmonella's Metabolism in Response to Neutrophil Hypochlorous Acid-Mediated Stress
Characterization and Salt Response in Recurrent Halotolerant Exiguobacterium sp SH31 Isolated From Sediments of Salar de Huasco, Chilean Altiplano
The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium
The transcription factor SlyA from Salmonella Typhimurium regulates genes in response to hydrogen peroxide and sodium hypochlorite
Comparative Genomics Analysis of a New Exiguobacterium Strain from Salar de Huasco Reveals a Repertoire of Stress-Related Genes and Arsenic Resistance
Hydrogen peroxide and hypochlorous acid influx through the major S. Typhimurium porin OmpD is affected by substitution of key residues of the channel
Pseudogenization of sopA and sopE2 is functionally linked and contributes to virulence of Salmonella enterica serovar Typhi
Participation of the Salmonella OmpD Porin in the Infection of RAW264.7 Macrophages and BALB/c Mice
ompW is cooperatively upregulated by MarA and SoxS in response to menadione
Probing the ArcA regulon under aerobic/ROS conditions in Salmonella enterica serovar Typhimurium
Salmonella enterica serovar Typhimurium BaeSR two-component system positively regulates sodA in response to ciprofloxacin
Characterization of the BaeSR two-component system from Salmonella Typhimurium and its role in ciprofloxacin-induced mdtA expression
Differential expression of the transcription factors MarA, Rob, and SoxS of Salmonella Typhimurium in response to sodium hypochlorite: down-regulation of rob by MarA and SoxS
Hypochlorous acid and hydrogen peroxide-induced negative regulation of Salmonella enterica serovar Typhimurium ompW by the response regulator ArcA
cAMP receptor protein (CRP) positively regulates the yihU-yshA operon in Salmonella enterica serovar Typhi
Response regulator ArcA of Salmonella enterica serovar Typhimurium downregulates expression of OmpD, a porin facilitating uptake of hydrogen peroxide
Cloning, purification and characterization of Geobacillus stearothermophilus V uroporphyrinogen-III C-methyltransferase: evaluation of its role in resistance to potassium tellurite in Escherichia coli
SoxS regulates the expression of the Salmonella enterica serovar Typhimurium ompW gene
SmvA, and not AcrB, is the major efflux pump for acriflavine and related compounds in Salmonella enterica serovar Typhimurium
The ompW (porin) gene mediates methyl viologen (paraquat) efflux in Salmonella enterica serovar Typhimurium
Catalases Are NAD(P)H-Dependent Tellurite Reductases
Identification of biogenic dimethyl selenodisulfide in the headspace gases above genetically modified Escherichia coli

Article (21)

Role of Salmonella Typhimurium small RNAs RyhB-1 and RyhB-2 in the oxidative stress response
The small RNA RyhB homologs from Salmonella typhimurium participate in the response to S-nitrosoglutathione-induced stress.
cAMP receptor protein (CRP) positively regulates the yihU-yshA operon in Salmonella enterica serovar Typhi
Expression of the ubiE gene of Geobacillus stearothermophilus V in Escherichia coli K-12 mediates the evolution of selenium compounds into the headspace of selenite- and selenate-amended cultures.
The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to beta-lactam antibiotics in gram-positive and gram-negative bacteria.
Biochemical characterization of a thermostable cysteine synthase from Geobacillus stearothermophilus V.
Geobacillus stearothermophilus V ubiE gene product is involved in the evolution of dimethyl telluride in Escherichia coli K-12 cultures amended with potassium tellurate but not with potassium tellurite.
The Geobacillus stearothermophilus V iscS gene, encoding cysteine desulfurase, confers resistance to potassium tellurite in Escherichia coli K-12.
Expression of Bacillus stearothermophilus LV cadmiun resistance genes in Escherichia coli causes hypersensitivity to cadmiun chloride.
The product of the cysK gene of Bacillus stearothermophilus V mediates potassium tellurite resistance in Escherichia coli.
Nucleotide sequence of the gene encoding the BstLVI DNA methyltransferase: comparison with other amino-DNA methyltransferases.
Cloning of a tellurite resistance determinant from Bacillus stearothermophilus V in Escherichia coli.
Structural studies of the BstVI restriction-modification proteins by fluorescence spectroscopy.
The amino acidic substitution of cysteine 167 by serine (C167S) in BstVI restriction endonuclease of Bacillus stearothermophilus V affects its conformation and thermostability.
Biochemical characterization of tellurite-reducing activities of Bacillus stearothermophilus V.
Studies on the heterologous expression of BstVI restriction endonuclease in Escherichia coli.
Cloning and expression of the bstLVIM gene from Bacillus stearothermophilus LV in Escherichia coli: purification and characterization of the M.bstLVI DNA methyltransferase.
The expression of the bstVIM gene from Bacillus stearothermophilus V is restricted to vegetative cell growth.
Plasmidios de resistencia a antibioticos en Shigella sonnei y Shigella flexneri, transferencia a Escherichia coli
Cloning the BstVI restriction-modification system in Escherichia coli.
Affinity labeling of Saccharomyces cerevisiae phosphoenolpyruvate carboxykinase with the 2',3'-dialdehyde derivative of ATP.
29
Claudia Saavedra

Full Professor

Departmento de Ciencias de la Vida

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

11
Iván Calderón

Assistant Professor / Academic Coordinator / Principal Investigator

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

9
Fernando Gil

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

4
Juan Fuentes

Académico

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

4
Alejandro Hidalgo

Associate Professor

Escuela de Química y Farmacia

Universidad Andres Bello

Santiago, Chile

3
Rubén Polanco

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO (UNAB)

SANTIAGO, Chile

2
José Pérez

Associate Professor

Biologia

Universidad Andres Bello

Santiago, Chile

2
Francisco Remonsellez

Professor

Ingenieria Química

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

2
Daniel Aguayo

Assistant Professor

Molecular Biophysics & Bioinformatics Group

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Eduardo Castro

Assistant Professor

Center for Bioinformatics and Integrative Biology

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Maria Opazo

Profesor honorarios

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Felipe Arenas

Profesor Asociado

Biología

UNIVERSIDAD SANTIAGO DE CHILE

Santiago, Chile

1
Raquel Quatrini

Research Associate

Fundación Ciencia & Vida

Santiago, Chile

1
Claudio Meneses

Profesor Asociado

Facultad de Ciencias de la Vida

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Daniel Paredes

Associate Professor

Department of Biological Sciences

Universidad Andrés Bello

Santiago, Chile

1
Bárbara Fuentes

Acádemcia, Investigadora, Jefe de Carrera

Departamento de Ingeniería Química

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

1
Fernando González

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

1
Carlos Areche

ASSOCIATE PROFESSOR

CHEMISTRY

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Claudio Vasquez

Full Professor

Biology Department

UNIVERSIDAD DE SANTIAGO DE CHILE

Santago, Chile

1
Rodrigo Pacheco

Full Professor; Head of the Laboratory of Neuroimmunology

Departamento de Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Alexis Aspee

Profesor Titular

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile