Man

Maria de los Angeles Garcia Robles

Profesor Titular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Líneas de Investigación


Neurobiology, Cell Biology, Cerebral glucosensing, obesity, feeding behavior, Glia-neuron interactions

Educación

  •  Cell and Molecular Biology, UNIVERSIDAD DE CONCEPCION. Chile, 2002
  •  Biochemistry, UNIVERSIDAD DE CONCEPCION. Chile, 1988

Experiencia Académica

  •   Associated Profesor Full Time

    UNIVERSIDAD DE CONCEPCION

    Biological Science

    Concepcion, Chile

    Enero 1990 - A la fecha

  •   Profesor Titular Full Time

    UNIVERSIDAD DE CONCEPCION

    Facultad de Ciencias Biológicas

    Concepción, Chile

    Enero 2015 - A la fecha

Formación de Capital Humano


undergraduate students
1. María José Yañez. Intracellular compartmentalization of GK and GKRP in response to glucose in hypothalamic glia. Bioengineering undergraduate Thesis. University of Concepcion. 2009.
2. Estefania Tarifeño. Cloning of Glucokinase and glucokinase regulatory protein from hypothalamic glia. Biology undergraduate Thesis. University of Concepcion. 2009.
3. Paula Llanos. Generation of an adenoviral vector for in vivo inhibition of GLUT2 and its evaluation in rat insulinoma cells. Bioengineering undergraduate Thesis. University of Concepcion. 2010
4. Claudio Carril. Inhibition of monocarboxylate transporter 1 (MCT1) in hypothalamic glia. Bioengineering undergraduate Thesis. University of Concepcion. 2011
5 María José Barahona. Adenoviral inhibition of monocarboxylate transporter 1 (MCT1) in hypothalamic glia: Study of feeding behavior. 2013

Master students
1. Roberto Elizondo. Differential characterization of the ability to release lactate by cortical glia and hypothalamic glia. Master Thesis University of Concepcion. 2010
2. Paula Llanos. Inhibition of GLUT2 in hypothalamic tanycytes and its effect on food intake in vivo. Master Thesis University of Concepcion. 2013
3. Magdiel Salgado. Glucose-dependent modulation of the interaction of GKRP and GKRP in glia hypothalamic. Magister Thesis University of Concepcion. 2013
4. Claudio Carril. “Sensing de lactato en cultivo de neuronas hipotalámicas”. Tesis de Magister en Bioquímica y Bioinformática. Facultad de Ciencias Biológicas, Universidad de Concepción. 2015

PhD students
1 Christian Cortes-Campos. Function and expression of monocarboxylate transporters in hypothalamic region. . Concepcion University. 2011. CONICYT fellowship.
2 Fernando Martinez. Low affinity glucose transporters expression in the sensing mechanism. . Concepcion University. 2012 CONICYT fellowship.
3 Roberto Elizondo. Análisis comparativo de la expresión y función de transportadores de glucosa y lactato de células gliales hipotalámicas y corticales. Doctorado en Ciencias Biológicas. Facultad de Ciencias Biológicas, Universidad de Concepción. 2016
4.Magdiel Salgado. Análisis comparativo de la expresión y función de transportadores de glucosa y lactato de células gliales hipotalámicas y corticales. Doctorado en Ciencias Biológicas. Facultad de Ciencias Biológicas, Universidad de Concepción
5.María José Barahona. Participación del transportador de glucosa 2, en Tanicitos, en la regulación de la secreción de Grelina y el comportamiento alimenticio. Doctorado en Ciencias Biológicas. Facultad de Ciencias Biológicas, Universidad de Concepción.
6. Antonia Recabal Beyer. Factores dietéticos y purinérgicos que promueven la proliferación de precursores neuronales hipotalámicos. Doctorado en Ciencias Biológicas. Facultad de Ciencias Biológicas, Universidad de Concepción.
7. Marianela Gómez Gaete. Diferenciación de Células Madres de la pulpa dental en Odontoblastos para la regeneración de Dentina. Programa de Doctorado en Odontología, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina


Difusión y Transferencia


PARTICIPACIÓN EN COMITÉS EDITORIALES, JURADOS, GRUPOS DE ESTUDIO

2015-2016 Evaluador en French National Research Agency, Gobierno Francés.

2013-2016. Evaluador en Comité Biología Fisiológica y Bioquímica, Programa de Formación de Capital Humano Avanzado, CONICYT

2005-2015. Evaluador proyectos Fondecyt Regular, Iniciación y posdoctorales

2005-2015. Evaluador de proyectos de investigación de la dirección de investigación, Universidad Austral de Chile.

2013 - 2015 Representante del Departamento de Biología Celular en la secretaría de Investigación de la Facultad de Ciencias Biológicas, Universidad de Concepción

2013-2016. Miembro del comité editorial de revista científica Frontiers in Neuroenergetics

2016. Miembro del Comité de Cooperación inter-Americana del American Society for Neurochemistry.

2015- 2016 Presidente da la Comisión de Evaluación de la Facultad de Ciencias Biológicas, Universidad de Concepción

2014- 2017 Miembro del Comité de Ética y Bioseguridad, Facultad de Ciencias Biológicas, Universidad de Concepción

2013-2016. Evaluador de manuscritos científicos, Journal of Neuroendocrinology

2013-2016. Evaluador de manuscritos científicos, Plos One

2013-2016. Evaluador de manuscritos científicos, Endocrinology

2014-2016. Evaluador de manuscritos científicos, Journal of Chemical Neuroanatomy

CONSULTORIAS INTERNACIONALES

2016. Docente invitado. Department of Cell & Developmental Biology, University of Colorado, Colorado, Estados Unidos.

2014. Docente invitado. Instituto de Investigaciones Bioquímicas de Bahía Blanca, Bahía Blanca, Argentina

2013. Docente invitado. Laboratorio de Biología Molecular e Ingeniería Genética del Centro GIGA, Universidad de Liege, Lieja, Bélgica

TRANSFERENCIA TECNOLÓGICA

Constitución de SPIN-OFF: CITCELL, Ingeniería de tejidos para el tratamiento de lesiones osteocondrales y artrosis. Constitución de empresa en Noviembre de 2016, la cual nace de la integración de tecnología desarrollada por la Dra. MA. García, en conjunto con la experiencia en cirugía articular aportada por traumatólogos como el Dr. Freddy Montolla y Dr. Alejandro Marty. Se postula la iniciativa a fondos del Programa regional de apoyo al emprendimiento (PRAE) y se genera un modelo de contrato con la Universidad de Concepción, en donde se estipulan las condiciones del licenciamiento de la tecnología y las regalías que se disponen para la Universidad y para la Facultad por el concepto de uso de Equipamiento y Espacios físicos.


Premios y Distinciones

  •   Maria García

    Concepcion University

    Chile, 2014

    Assignment academic merit


Tipos de Producción
 

Article (45)

When a Little Bit More Makes the Difference: Expression Levels of GKRP Determines the Subcellular Localization of GK in Tanycytes
Connexin-43 Gap Junctions Are Responsible for the Hypothalamic Tanycyte-Coupled Network
Glial hypothalamic inhibition of GLUT2 expression alters satiety, impacting eating behavior
Metabolic strategies for the degradation of the neuromodulator agmatine in mammals
SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer-related phenotypes
Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior
Hypothalamic Neurogenesis as an Adaptive Metabolic Mechanism
Mammalian agmatinases constitute unusual members in the family of Mn2+-dependent ureahydrolases
Cloning of two LIMCH1 isoforms: characterization of their distribution in rat brain and their agmatinase activity
Inhibition of hypothalamic MCT1 expression increases food intake and alters orexigenic and anorexigenic neuropeptide expression
Monocarboxylate Transporters (MCTs) and their Role in Hypothalamic Glucosensing
Insight on the interaction of an agmatinase-like protein with Mn2+ activator ions
Dynamic Localization of Glucokinase and Its Regulatory Protein in Hypothalamic Tanycytes
SVCT2 transporter expression is post-natally induced in cortical neurons and its function is regulated by its short isoform
The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism
Clinical and experimental approaches to knee cartilage lesion repair and mesenchymal stem cell chondrocyte differentiation
Dynamic expression of the sodium-vitamin C co-transporters, SVCT1 and SVCT2, during perinatal kidney development
Human choroid plexus papilloma cells efficiently transport glucose and vitamin C
MCT2 Expression and Lactate Influx in Anorexigenic and Orexigenic Neurons of the Arcuate Nucleus
Superoxide-dependent uptake of vitamin C in human glioma cells
Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels
Glucose Transporter 1 and Monocarboxylate Transporters 1, 2, and 4 Localization within the Glial Cells of Shark Blood-Brain-Barriers
Typical and atypical stem cells in the brain, vitamin C effect and neuropathology
Expression and Distribution of Facilitative Glucose (GLUTs) and Monocarboxylate/H+ (MCTs) Transporters in Rat Olfactory Epithelia
Insulin Regulates GLUT1-Mediated Glucose Transport in MG-63 Human Osteosarcoma Cells
MCT Expression and Lactate Influx/Efflux in Tanycytes Involved in Glia-Neuron Metabolic Interaction
Expression and localization of an agmatinase-like protein in the rat brain
Glial glucokinase expression in adult and post-natal development of the hypothalamic region
The Na+-dependent l-ascorbic acid transporter SVCT2 expressed in brainstem cells, neurons, and neuroblastoma cells is inhibited by flavonoids
Differential distribution of the Sodium-vitamin C cotransporter-1 along the proximal tubule of the mouse and human kidney
Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75
Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: Ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues
Cytogenetic damage in female Chilean agricultural workers exposed to mixtures of pesticides
Ependymal cell differentiation and GLUT1 expression is a synchronous process in the ventricular wall
Novel expression of liver FBPase in Langerhans islets of human and rat pancreas
Sodium vitamin C cotransporter SVCT2 is expressed in hypothalamic glial cells
Vitamin C uptake and recycling among normal and tumor cells from the central nervous system
Differential regulation of glucose transporter expression by estrogen and progesterone in Ishikawa endometrial cancer cells
Regulation by insulin and insulin-like growth factor of 2-deoxyglucose uptake in primary ependymal cell cultures
Estrogen and progesterone up-regulate glucose transporter expression in ZR-75-1 human breast cancer cells
Human brain synembryn interacts with Gs alpha and Gq alpha and is translocated to the plasma membrane in response to isoproterenol and carbachol
Hypothalamic ependymal-glial cells express the glucose transporter GLUT2, a protein involved in glucose sensing
Ethodin: pharmacological evidence of the interaction between smooth muscle and mast cells in the myometrium.
On the mechanism of action of ethodin in inducing myometrium contractions
Significantly reduced expression of the proteoglycan decorin in Alzheimer's disease fibroblasts

Abstract (17)

MCT2 in brain glucose sensing
Spectral-confocal and microdissection analysis to define the glial cells distribution and glucose/lactate transporters expression
MCT EXPRESSION AND LACTATE INFLUX/EFFLUX IN HYPOTHALAMIC GLIAL CELLS
GLIAL GLUCOKINASE EXPRESSION IN ADULT AND POST-NATAL DEVELOPMENT OF HYPOTHALAMIC REGION
MCT1 AND MCT4 ARE LOCATED IN GLIAL CELLS OF HYPOTHALAMUS
Glucokinase expression in hypothalamic glial cells
SVCT2 transporter in early post-natal brain cortex
Vitamin C transporters in ependymal cells
Analysys of glucokinase and glucokinase regulatory protein expression in hypothalamic glial cells
Lactate and glucose transporters expression in brain glial cells and hypothalamic tanycytes
Cellular polarization of glucose transporter GLUT1 and sodium-ascorbic acid cotransporter SVCT2 in human choroid plexus
Glucokinase is expressed in mouse hypothalamic tanycytes, an enzyme involved in glucose sensing
Glucose transporter GLUT1 and ascorbic acid transporter SVCT2 are polarized in different membranes in human choroid plexus cells
Expression of vitamin C transporter SVCT2 in hypothalamic glial cells. An immunohistochemical and kinetic analysis
Hypothalamic ependymal cells express the glucose transporter GLUT2, a protein involved in glucose sensing
Expression and function of glucose and vitamin C transporters in human tumoral choroids plexus cells.
Glucose and vitamin C uptake in ependymal cells of brain hypothalamus. Glut1, Glut2 and SVCT expression and function.

Review (2)

The role of tanycytes in hypothalamic glucosensing
Glucose Transporters in Sex Steroid Hormone Related Cancer

Book Whole (1)

Molecular Characteristics, Regulation, and Function of Monocarboxylate Transporters

Dtp Import/Article (1)

Brain monitoring of glucose homeostasis. Neuron-glia interactions.
71
Maria Garcia

Profesor Titular

Biología Celular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

27
Francisco Nualart

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

14
Katterine Salazar

Associate Professor

Cell Biology

University of Concepcion

Concepción, Chile

12
Fernando Martinez

Assistant Professor

Cell Biology

Universidad de Concepción

Concepción, Chile

11
Teresa Caprile

Associate profesor

DPTO. BIOLOGIA CELULAR,

UNIVERSIDAD DE CONCEPCIÓN

Concepcion, Chile

10
Elena Uribe

Associate Professor

Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

9
Carola Millán

Profesor

de Ciencias

UNIVERSIDAD ADOLFO IBAÑEZ FACULTAD DE ARTES LIBERALES

Viña del Mar, Chile

9
Viviana Ulloa

Profesional Superior

Dirección de Estudios Estratégicos

Universidad de Concepción

Concepción, Chile

9
Juan Vera

Full professor

Pathophysiology

University of Concepcion

Concepción, Chile

8
Allisson Astuya

profesor asociado

Departamento de Oceanografia de la Universidad de Concepción

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

6
Alejandro Yañez

Full professor

Biochemistry and microbiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

4
Gareth Owen

Profesor Titular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Roberto Elizondo

Investigador Post-Doctoral

Universidad de los Andes

Santiago, Chile

4
Antonia Recabal

Estudiante de doctorado

Biología Celular

Universidad de Concepción

Concepción, Chile

3
Juan Tapia

Profesor

UNIVERSIDAD DE TALCA

Talca, Chile

2
Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

2
Romina Bertinat

Investigador asociado

Centro de Microscopía Avanzada, CMA BIO BIO

Universidad de Concepcion

Concepción, Chile

2
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

2
Juan Pablo Henriquez

Associate Professor

Cell Biology

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPARTAMENTO DE BIOLOGÍA CELULAR

Concepción, Chile

2
Andres Carvajal

Investigador

INIA

Osorno, Chile

2
Jose Guzman

Associate professor

Physiology

University of Concepcion

Concepcion, Chile

2
Juan Saez

Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jaime Cofré

Profesional investigador

Universidad San Sebastián

Concepción, Chile

1
Ariel Castro

Associate Professor

Department of Biochemistry and Molecular Biology

UNIVERSIDAD DE CONCEPCION

concepciòn, Chile

1
Sergio Onate

Associate Professor

Medical Specialties

UNIVERSIDAD DE CONCEPCION, DEPARTAMENTO FISIOPATOLOGIA

concepcion, Chile

1
Viviana Montecinos

Assistant Professor

Hematology Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Juan Cárcamo

Full Professor

Instituto de Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

1
Juan Sáez

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Vania Figueroa

Profesor Asistente

Instituto de Ciencias de la Salud

Universidad de O’Higgins

Rancagua, Chile

1
Juan Orellana

Assistant Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Maria Poblete

Profesor Auxiliar

Anatomia, Histologia y Patologia

Universidad Austral de Chile

Valdivia, Chile

1
Juan Reyes

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

1
Fernando Sepúlveda

Representante Legal

NeuroLabs

Talcahuano, Chile

1
Victor Castro

Profesor Asistente

Departamento de Biología

UNIVERSIDAD DE CHILE

Ñuñoa, Chile

1
Jose Sarmiento

Assistant Professor

Physiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Alejandro Godoy

Associate Professor

Physiological Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Maximiliano Figueroa

Assstant Professor

Universidad de Concepción

Concepción, Chile

1
Felipe Zúñiga

Profesor Asistente

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Martin Montecino

Director

Center for Biomedical Research

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Luciano Ferrada

Investigador

Biología celular

Universidad de Concepción

Concepcion, Chile

1
Estefania Tarifeño

Postdoctoral Researcher

Centro de Biotecnología

Universidad de Concepción

Concepción, Chile

1
Roxana Pincheira

Profesor Asociado

Bioquímica y Biología Celular

Universidad de Concepcion

Concepción, Chile

1
Matias Hepp

Docente - Investigador

Ciencias Basicas

universidad catolica de la santisima concepcion

Concepcion, Chile