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Francisco Antonio Pérez Bravo

DIRECTOR

UNIVERSIDAD DE CHILE

Santiago, Chile

Epigenetics; Gene Regultation; Metabolisms; Vitamin D; Functional Foods.

Bioquímica , UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 1990
Biología Molecular, Universidad Complutense de Madrid. España, 1996
Bioquímica , UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 1989

PROFESOR TITULAR Full Time

UNIVERSIDAD DE CHILE

MEDICINA

SANTIAGO, Chile

2009 - A la fecha
PROFESOR TITULAR Part Time

UNIVERSIDAD DE CHILE

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LOS ALIMENTOS (INTA)

SANTIAGO, Chile

1995 - A la fecha
Director Full Time

UNIVERSIDAD DE CHILE

Instituto de Nutrición y Tecnología de los Alimentos (INTA)

Santiago, Chile

2018 - A la fecha

THESIS DIRECTIONS (2015-2020)

1. Bárbara Echiburú López. Magister in Biotechnology. Science Faculty. Universidad de Chile. Tittle: Expression profile of inflammatory markers: IL-6-MCP-1 and adiponectin in adipose tissue of postmenopausal women with polycystic ovary síndrome. Director: Dr. Francisco Pérez-Bravo. January 2015.

2. Carolina Pizarro Acevedo. Magister in Biotechnology. Science Faculty. Universidad de Chile. Tittle: miRNA expression in type 1 diabetic patiens: association with autoimmunity and inflammation. Director: Dr. Francisco Pérez-Bravo. January 2015.

3. Francisca Concha Celume. Magister in Genetics. Medicine Faculty. Universidad de Chile. Title: Methylation patterns of MCP-1 promotor gene in childrens from polycystic ovary síndrome mothers. Director: Dr. Francisco Pérez-Bravo. July 2015.

4. Viviana Arroyo J. Magister in Human Nutrition. Instituto de Nutrición y Tecnología de los Alimentos (INTA). Universidad de Chile. Title: Methylation state in CpG isles of the MCP-1 promotor gene and their correlation with homocistein and folic acid in type 1 diabetic patiens. Director: Dr. Francisco Pérez-Bravo. July 2015.

5. Holguer Santiago Estrella. Magister in Genetics. Medicine Faculty. Universidad de Chile. Title: microRNA - 22 and microRNA-150 expression profile in perypheral mononuclear cells of type 1 diabetic patients and the relationship with autoinmune and clinical charasteristics. Director: Dr. Francisco Pérez-Bravo. November 2015.

6. Lissette Duarte Silva. Magister in Human Nutrition. Instituto de Nutrición y Tecnología de los Alimentos (INTA). Universidad de Chile. Title: microRNA-378 expression profile and IL-6 levels in type 1 diabetic patients with differential body fat composition. Director: Dr. Francisco Pérez-Bravo. August 2017.

7. Karla Bascuñan Gamboa. Phd Nutritional Sciences (Programa Doctorado DOCNUTAL). Universidad de Chile. Doctoral Thesis: miRNAs and inflammation in celiac disease patients. Directors: Dra. Magdalena Araya and Dr. Francisco Pérez-Bravo. May 2017.

8. Alvaro Pérez Bazán. PhD Nutritional Sciences (Programa Doctorado DOCNUTAL). Universidad de Chile. Doctoral Thesis: Effect of zinc suplemmentation in type 2 diabetic patients on glucagón secretion. Directors: Dr. Manuel Ruz and Dr. Francisco Pérez-Bravo. December 2017.

9. Franco González Villar: PhD Candidate Veterinary and Silvoagropecuary Sciences (Programa Doctorado DCSAV). Uiversidad de Chile. Doctoral Thesis: Analysis of hormonal and immunological factors on the canine diabetes mellitus characterization. Director: Dr. Francisco Pérez-Bravo. October 2021.

10. Francisca Concha Celume: PhD Candidate Nutritional Sciences (Programa Doctorado DOCNUTAL). Universidad de Chile. Doctoral Thesis: Intergenerational effects of sucralose and stevia in mice models. Directors: Dr. Martín Gotteland and Dr. Francisco Pérez-Bravo. Thesis in Progress 2020-2022.

Premio Julio Santiago

Eli Lilly Awardee

Uruguay, 2001

Asociación Latinoamericana de Diabetes. Premio al Investigador Joven Destacado
Premio Sociedad Chilena de Endocrinología y Diabetes

Sociedad Chilena de Endocrinología y Diabetes

Chile, 2014

Premio al Investigador Destacado 2014


Nutritional Status and Serum Levels of Micronutrients in an Elderly Group Who Participate in the Program for Complementary Food in Older People (PACAM) from the Metropolitan Region, Santiago de Chile Arazo-Rusindo, Migdalia Caridad; Zuniga, Rommy N.; Cortes-Segovia, Pablo; Benavides-Valenzuela, Sergio; Perez-Bravo, Francisco; Castillo-Valenzuela, Oscar; Mariotti-Celis, Maria Salome Article ISI NUTRIENTS (2022)
Response to Analysis of serum 25-hydroxyvitamin D levels involves taking into account several confounding factors. Pérez-Bravo F, Arredondo-Olguín M, Castillo-Valenzuela O Article EUROPEAN JOURNAL OF CLINICAL NUTRITION (2022)
Determination of autoantibodies in dogs with diabetes mellitus. González-Villar F, Pérez-Bravo F Article VETERINARY WORLD (2021)
Vitamin D status and obesity in children from Chile Perez-Bravo, Francisco; Duarte, Lissette; Arredondo-Olguin, Miguel; Iniguez, German; Castillo-Valenzuela, Oscar Article ISI EUROPEAN JOURNAL OF CLINICAL NUTRITION (2021)
Body fat composition and mir-378 expression profiling in patients with type 1 diabetes Duarte L, García-Díaz D, Pérez-Bravo F. Article Ann Pediatr Endocrinol Metab (2020)
DNA methylation in promoter regions of genes involved in the reproductive and metabolic function of children born to women with PCOS Echiburu, Barbara; Milagro, Fermin; Crisosto, Nicolas; Perez-Bravo, Francisco; Flores, Cristian; Arpon, Ana; Salas-Perez, Francisca; Recabarren, Sergio E.; Sir-Petermann, Teresa; Maliqueo, Manuel Article ISI EPIGENETICS (2020)
A miRNA-Based Blood and Mucosal Approach for Detecting and Monitoring Celiac Disease BascuÃ±Ã¡n K.A.; PÃ©rez-Bravo F.; Gaudioso G.; Vaira V.; Roncoroni L.; Elli L.; Monguzzi E.; Araya M. Article ISI SCOPUS DIGESTIVE DISEASES AND SCIENCES (2019)
[Overweight and obesity in celiac disease=> expression of the interleukin profile Th17]. Parada, Alejandra; Aguirre, Carolina; Pérez-Bravo, Francisco Article Nutricion hospitalaria (2018)
Avoiding Small Intestinal Biopsies for Diagnosis of Celiac Disease in Children: A Reliable Strategy for All Patients? Araya, Magdalena; Diaz, Julia; Oyarzun, Amaya; Lucero, Yalda.; Alarcon, Teresa; Gonzalez, Monica; Canales, Paulina; Fierro, Liliana; Perez-Bravo, Francisco Article ISI SCOPUS JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2018)
Enlarged adipocytes in subcutaneous adipose tissue associated to hyperandrogenism and visceral adipose tissue volume in women with polycystic ovary syndrome. Echiburú, Bárbara; Pérez-Bravo, Francisco; Galgani, José E; Sandoval, Daniel; Saldías, Carolina; Crisosto, Nicolás; Maliqueo, Manuel; Sir-Petermann, Teresa Article Steroids (2018)
Expression of miR-155, miR-146a, and miR-326 in T1D patients from Chile: relationship with autoimmunity and inflammatory markers Garcia-Diaz, DF; Pizarro, C; Camacho-Guillen, P; Codner, E; Soto, N; Perez-Bravo, F Article ISI SCOPUS ARCHIVES OF ENDOCRINOLOGY METABOLISM (2018)
miR15a and miR16 in Chilean type 1 diabetes patients: possible association with apoptosis, inflammatory, or autoimmunity markers Garcia-Diaz, D. F.; Camacho-GuillÃ©n P.; Codner E.; PÃ©rez-Bravo F. Article SCOPUS Journal of Endocrinological Investigation (2018)
+ Is Associated with Milder Duodenal Histological Changes in Chilean Celiac Patients. Lucero, Yalda; Oyarzún, Amaya; O'Ryan, Miguel; Quera, Rodrigo; Espinosa, Nelly; Valenzuela, Romina; Simian, Daniela; Alcalde, Elisa; Arce, Claudio; Farfán, Mauricio J; Vergara, Alejandra F; Gajardo, Iván; Mendez, Jocelyn; Carrasco, Jorge; Errázuriz, Germán; Gonzalez, Mónica; Ossa, Juan C; Maiza, Eduardo; Perez-Bravo, Francisco; Castro, Magdalena; Araya, Magdalena Article Frontiers in cellular and infection microbiology (2017)
Epigenetics in type 1 diabetes=> TNFa gene promoter methylation status in Chilean patients with type 1 diabetes mellitus. Arroyo-Jousse, Viviana; Garcia-Diaz, Diego F; Codner, Ethel; Pérez-Bravo, Francisco Article The British journal of nutrition (2016)


El tejido adiposo como órgano endocrino Pérez-Bravo F, Salas-Pérez F BookSection (2022)
ALIMENTOS FUNCIONALES Perez, Francisco; Atalah, E.; Gotteland, Martin BookSection (2016)
NUTRIGENOMICA: NUTRIENTES Y EXPRESION GENICA Perez, Francisco BookSection (2016)
VITAMINA D Y CALCIO (FOSFORO Y MAGNESIO) Perez, Francisco BookSection (2016)
VITAMINA E Y K Diego F García-Díaz; Perez, Francisco BookSection (2016)
¿Qué miran y evalúan los editores y revisores de las revistas?. Arredondo M, Pérez F BookSection


NUTRICION Y SALUD RUZ, MANUEL H; Perez, Francisco BookWhole (2016)


Diseño racional del sistema de administración oral de florotaninos como alternativa para controlar el estado metabólico de los ancianos con sarcopenia o riesgo de sarcopenia Mariotti-Celis, María Salomé; Francisco Pérez-Bravo Proyecto (2022)
Efecto de la ingesta diaria de una crema de legumbres con bioaccesibilidad controlada de nutrientes y adecuada aceptabilidad sensorial sobre la inflamación, parámetros metabólicos, masa, fuerza y función muscular en adultos mayores Francisco Pérez-Bravo; Zuñiga, Rommy; Salome Mariotti-Celis, Maria; Albala, Cecilia Hortensia; Castillo, Oscar; Benavides, Sergio; Alviña W, Marcela; Claudia Vega; Cortes, Pablo A Proyecto (2021)
Engineering design of β-lactoglobulin fluid gels as carriers for controlled delivery of polyphenols: effect of microstructure on the in vitro and in vivo oxidative stress and inflammatory response after digestión Zuñiga, Rommy; Troncoso, Elizabeth.; Francisco Pérez-Bravo Proyecto (2020)
INTERACTION BETWEEN NEGATIVE REGULATION GENES OF T LYMPHOCYTE=> CTLA-4 AND PD-1 ON THE APOPTOTIC EVENTS ASSOCIATED TO TYPE 1 DIABETES PREDISPOSITION FONDECYT (1100075) Proyecto 2010-2013 Inv. Responsable
RELACION ENTRE AUTO-INMUNIDAD Y MUERTE CELULAR PROGRAMADA EN LA DIABETES TIPO 1=> ¿PUEDE LA ASOCIACION ENTRE LOS GENES CTLA-4 Y ANTICUERPOS ANTI-CASPASA-8 RESPONDER ESTA INTERROGANTE?. FONDECYT (7070077) Proyecto 2007-2008 Inv. Responsable
RELACION ENTRE AUTO-INMUNIDAD Y MUERTE CELULAR PROGRAMADA EN LA DIABETES TIPO 1=> ¿PUEDE LA ASOCIACION ENTRE LOS GENES CTLA-4 Y ANTICUERPOS ANTI-CASPASA-8 RESPONDER ESTA INTERROGANTE?. FONDECYT (1060790) Proyecto 2006-2009 Inv. Responsable
INTERACCION ENTRE POLIMORFISMO DEL RECEPTOR DE VITAMINA D (VDR) Y MARCADORES INMUNOGENETICOS HLA-DQB1* EN LA DIABETES TIPO 1=> POSIBLE ROL MODULADOR DE LA VITAMINA D. FONDECYT (1030680) Proyecto 2003-2006 Inv. Responsable
INTERACCION ENTRE FACTORES NUTRICIONALES , GENETICOS E INMUNOLOGICOS EN LA PATOGENESIS DE LA DIABETES TIPO 1 EN CHILE=> DISENO DE CASOS Y PADRES COMO CONTROLES FONDECYT (1000944) Proyecto 2000-2003 Inv. Responsable