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Luis Pablo Cid Soto

Principal Research

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

Canales de cloruro y potasio de epitelios; Estructura -funcion de canales ionicos; Renal and Intestinal physiology and pathophysiology.

Medical Doctor, UNIVERSIDAD DE CHILE. Chile, 1982
Physiologic and Genetics, Johns Hopkins University. Estados Unidos, 1995
Magister in Cs. Physicians Mention Pathophysiology, UNIVERSIDAD DE CHILE. Chile, 2000

Instructor Full Time

UNIVERSIDAD DE CHILE

Faculty of Medicine

Santiago, Chile

1988 - 1991
Postdoctoral Fellow Full Time

Johns Hopkins University

Baltimore, Estados Unidos

1991 - 1995
Instructor Full Time

UNIVERSIDAD DE CHILE

Faculty of Medicine

Santiago, Chile

1995 - 2000

Medico Full Time

.

Lautaro, Chile

1983 - 1987

Undergraduate Students:

* Juan Pablo Donoso. “Study of interaction of TASK-2 with proteins involved in renal bicarbonate reabsorption: Carbonic Anhydrase II and Sodium Bicarbonate Cotransporter”. Undergraduate Medical Technologist. Universidad Austral de Chile. Finished 2014.
* Karen López C. "Expression of the potassium channel Kir 7.1 and NHE3 sodium proton exchanger in TASK2 KO mice". Undergraduate Biochemist. Universidad Austral de Chile. Finished in 2013.
* Sandra Villanueva S. “Effect of the genetic inactivation of the KCNQ1/KCNE3 potassium channel in the intestinal chloride secretion using murine models”. Undergraduate Biochemist Universidad Austral de Chile. Finished in 2013.
* Alexandra Alvarez A. “Generation of a transgenic mouse expressing a sensor of extracellular in the basolateral membrane of in the renal proximal tubule”. Undergraduate Biochemist Universidad Austral de Chile. Finished in 2011.
* Moisés Sandoval C. Generation of a genetically coded extracellular pH sensor to measure pH in basolateral epithelia microdomains. Undergraduate Biochemist Universidad Austral de Chile. Finished in 2009.
* Andrea Olave E. “Subcellular localization of ClC-2 chloride channel mutants using IFI”. Undergraduate Medical Technologist. Universidad Austral de Chile. Finished in 2009.
* Johanna Burgos V. “Study of the inhibitory mechanism by extracellular acid pH of the chloride channel ClC-Kb”. Undergraduate Biochemist Universidad Austral de Chile. Finished in 2007.
* Carola Maturana F. "Study of the interaction of the SPAK protein kinase with the ClC-2 chloride channel". Undergraduate Biochemist Universidad Austral de Chile. Finished in 2007.
* Gaspar Peña M. "Localization basolateral of the ClC-2 echoride channel in epithelial cell lines". Undergraduate Biochemist Universidad Austral de Chile. Finished 2005.
* Yamil Yusef R. "Effect of an intronic mutation in the function of the ClC-2 choride channel". Undergraduate of the Marine Biology. Universidad Austral de Chile. Finished in 2004.
* Leandro Zúñiga H. "Study of the mechanism of the ClC-2 channel opening by site directed mutagenesis of cysteine 256". Undergraduate Biochemist Universidad Austral de Chile. Finished 2002.
* Isabel Cornejo A. "Cloning and expression of the chloride channel ClC-5 from intestine epithelia of guinea pig".Undergraduate Medical Technologist. Universidad Austral de Chile. Finished in 2000.
* Felipe Estrada A. Generation of knock-in mice with a double lysine mutation in TASK-2 potassium channel using CRISPR-Cas9 technology. Undergraduate Medical Technologist. Universidad Austral de Chile. Ongoing.

Master Student:
Hugo Roa R. "Phenotypic rescue of the KO TASK-2 mouse by expression of the pH sensors mutants of the channel in the renal proximal tubule". Magister in Cellular Biology. Universidad Austral de Chile. Finished 2016.

PhD Student:
* Isabel Cornejo A. "Study of the traffic and membrane surface expression of the ClC-2 chloride channel. Cellular and Molecular Biology PhD. Universidad Austral de Chile. Finished in 2007.

Visit abroad
* Karen Lopez visit the Institut national de la santé et de recherche médicale (Inserm) in Paris and work in the laboratory of Dr. Jacques Teulon, learning the technique of perfusion via the aorta artery, the preparation of samples for the immunofluorescence of kidney, protein quantification and westernblot of renal proteins, 01st May to 01st June 2013.
* Karen Lopez visit the Hôpital Européen Georges-Pompidou in Paris and work in the laboratory of Dr. Dominique Eladari, to perform some analysis of samples, 01st May to 01st June 2013.

Visit in Chile
* Working meetings, Dr. Dominique Eladari and Dra. Regine Chambrey, Université de Paris Decartes Paris, 19th to 31th December 2016.

Collaborative Activities
* Course Program Modules Scholarship Nephrology, "Use of genetically modified animals in the study of physiology and renal disease", Chilean Society of Nephrology, 22- 25 april 2015, Santiago, Chile.
* Course Science and Poetry, "A surprising immune system in bacteria gives us tools to modify complex genomes", Universidad Austral de Chile, 10 May 2016, Valdivia, Chile.

National collaborators
* Leopoldo Ardiles (Universidad Austral de Chile, Valdivia).
* Sandra Bravo (Universidad Austral de Chile, Puerto Montt).
* Marcelo Catalán (Universidad Arturo Prat, Iquique).
* Wendy González (Universidad de Talca, Talca).
* Danilo González-Nilo (Universidad Andrés Bello, Santiago).

International collaborators
* Jacques Teulon and Marc Paulais (Université Pierre at Marie Curie, France),
* Olga Andrini (Université Claude Bernard, France),
* Brian Harvey (Royal College of Surgeons, Dublin Ireland),
* Sarah C. Lummis (University of Cambridge, UK),
* David M. Valenzuela and Venus Lai (Regeneron Pharmaceuticals, NY, USA),
* Dominique Eladari and Régine Chambrey (Université de La Réunion, France.),
* Thomas Jentsch (Leibniz Molecular Pharmacology Institute, Berlin Germany).


Altered phosphatidylinositol regulation of mutant inwardly rectifying K+ Kir7.1 channels associated with inherited retinal degeneration disease. Vera, E.; Cornejo, I; Niemeyer, MI; Sepulveda, FV; Cid, L. Pablo Article Journal of Physiology (2021)
Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action Catalan, Marcelo A.; Julio-Kalajzic, Francisca; Niemeyer, Maria Isabel; Cid, Luis Pablo; Sepulveda, Francisco V. Article ISI CELLS (2020)
A novel Kir7.1 splice variant expressed in various mouse tissues shares organisational and functional properties with human Leber amaurosis-causing mutations of this K+ channel. Vera, E; Cornejo, I.; Burgos, J.; Niemeyer, MI; Sepúlveda FV; Cid, L. Pablo Article BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
Kir7.1 inwardly rectifying K+ channel is expressed in ciliary body non pigment epithelial cells and might contribute to intraocular pressure regulation. Burgos, J.; Villanueva, S.; Ojeda, M.; Cornejo I.; Cid, L. Pablo; Sepulveda, FV Article EXPERIMENTAL EYE RESEARCH (2019)
K-2P TASK-2 and KCNQ1-KCNE3 K+ channels are major players contributing to intestinal anion and fluid secretion Julio-Kalajzi?, Francisca; Villanueva, Sandra; Burgos, Johanna; Ojeda, Margarita; Cid, L. Pablo; Jentsch, Thomas J.; Sepúlveda, Francisco V. Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2018)
Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse. Philp, Amber R; Riquelme, Texia T; Millar-Büchner, Pamela; González, Rodrigo; Sepúlveda, Francisco V; Cid, L Pablo; Flores, Carlos A Article Scientific reports (2018)
Reply from L. P. Cid, T. J. Jentsch and F. V. Sepulveda: intestinal electrolyte and fluid secretion - a model in trouble? Cid, L. P.; Jentsch, T.J.; Sepúlveda, F.V. Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2018)
Tissue Distribution of Kir7.1 Inwardly Rectifying K+ Channel Probed in a Knock-in Mouse Expressing a Haemagglutinin-Tagged Protein Cornejo, I; Villanueva, S; Burgos, J; Lopez-Cayuqueo, KI; Chambrey, R; Julio-Kalajzic, F; Buelvas, N; Niemeyer, MI; Figueiras-Fierro, D; Brown, PD; Sepulveda, FV; Cid, LP Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2018)
Phosphatidylinositol (4,5)bisphosphate dynamically regulates the K-2P background K+ channel TASK-2 Niemeyer, María Isabel; Cid, L. Pablo; Paulais, Marc; Teulon, Jacques; Sepúlveda, Francisco V. Article ISI SCOPUS SCIENTIFIC REPORTS (2017)
Gating, Regulation, and Structure in K2P K+ Channels: In Varietate Concordia? Niemeyer, M. I.; Cid, L. P.; Gonzalez, W.; Sepulveda, F. V. Article ISI SCOPUS Molecular Pharmacology (2016)
Cleft Palate, Moderate Lung Developmental Retardation and Early Postnatal Lethality in Mice Deficient in the Kir7.1 Inwardly Rectifying K+ Channel Villanueva, Sandra; Burgos, Johanna; Lpez-Cayuqueo, Karen I.; Lai, Ka-Man Venus; Valenzuela, David M.; Cid, L. Pablo; Seplveda, Francisco V.; Zhang, Zhe Article ISI SCOPUS PLOS ONE (2015)
Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels. Sepúlveda, Francisco V; Pablo Cid, L; Teulon, Jacques; Niemeyer, María Isabel Article Physiological reviews (2015)
Identification and functional expression of a glutamate- and avermectin-gated chloride channel from Caligus rogercresseyi, a southern Hemisphere sea louse affecting farmed fish. Cornejo, Isabel; Andrini, Olga; Niemeyer, María Isabel; Marabolí, Vanessa; González-Nilo, F Danilo; Teulon, Jacques; Sepúlveda, Francisco V; Cid, L Pablo Article PLoS pathogens (2014)
Zebrafish and mouse TASK-2 K+ channels are inhibited by increased CO2 and intracellular acidification Pena-Munzenmayer, G; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2014)
An Extracellular Ion Pathway Plays a Central Role in the Cooperative Gating of a K-2P K+ Channel by Extracellular pH Gonzalez, W; Zuniga, L.; Cid, LP; Arevalo, B.; Niemeyer, MI; Sepulveda, FV Article ISI SCOPUS Journal of Biological Chemistry (2013)
G protein modulation of K-2P potassium channel TASK-2 Añazco C.; Pena-Munzenmayer, G; Araya C.; Cid, LP; Sepulveda, FV; Niemeyer, MI Article ISI SCOPUS Pflugers Archiv European Journal of Physiology (2013)
G protein modulation of K_2P potassium channel TASK-2: a role of basic residues in the C-terminus domain. Añazco, C., Peña-Münzenmayer, G., Araya, C., Cid, L.P., Sepúlveda, F.V. Article Pflügers Arch. Eur. J.Physiol. (2013)
Novel CLCNKB Mutations Causing Bartter Syndrome Affect Channel Surface Expression Keck, M; Andrini O.; Lahuna, O; Burgos, J; Cid, LP; Sepulveda, FV; L'Hoste, S; Blanchard, A.; Vargas-Poussou, R; Lourdel S.; Teulon, J Article ISI SCOPUS Human Mutation (2013)
Extracellular pH in Restricted Domains as a Gating Signal for Ion Channels Involved in Transepithelial Transport Sandoval M.; Burgos, J; Sepulveda, FV; Cid, LP Article ISI BIOLOGICAL & PHARMACEUTICAL BULLETIN (2011)
Gating of a pH-Sensitive K-2P Potassium Channel by an Electrostatic Effect of Basic Sensor Residues on the Selectivity Filter Zuniga, L.; Cid, L. P.; Sepulveda, F. V.; Niemeyer M.I.; Marquez, V; Gonzalez-Nilo F.D.; Chipot, C Article ISI PLOS ONE (2011)
Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K+ channels Alzamora, R; O'Mahony, F; Bustos, V; Rapetti-Mauss, R; Urbach, V; Cid, LP; Sepulveda, FV; Harvey, BJ Article ISI SCOPUS Journal of Physiology (2011)
Separate Gating Mechanisms Mediate the Regulation of K-2P Potassium Channel TASK-2 by Intra- and Extracellular pH Niemeyer, MI; Cid, LP; Pena-Munzenmayer, G; Sepulveda, FV Article ISI SCOPUS Journal of Biological Chemistry (2010)
Strain-dependent differences in electrogenic secretion of electrolytes across mouse colon epithelium Flores, CA; Cid, LP; Sepulveda, FV Article ISI SCOPUS Experimental Physiology (2010)
Rapid Recycling of ClC-2 Chloride Channels Between Plasma Membrane and Endosomes: Role of a Tyrosine Endocytosis Motif in Surface Retrieval Cornejo I.; Niemeyer, MI; Zuniga, L.; Yusef, YR; Sepulveda, FV; Cid, LP Article ISI SCOPUS JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons Niemeyer, MI; Cid, LP; Yusef, YR; Briones, R; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2009)
A genetically encoded ratiometric sensor to measure extracellular pH in microdomains bounded by basolateral membranes of epithelial cells Urra, J; Sandoval M.; Cornejo I.; Barros, LF; Sepulveda, FV; Cid, LP Article ISI SCOPUS PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2008)
Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel Niemeyer, MI; Gonzalez-Nilo, FD; Zuniga, L.; Gonzalez, W; Cid, LP; Sepulveda, FV Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Gating of two-pore domain K+ channels by extracellular pH Niemeyer, MI; Gonzalez-Nilo, FD; Zuniga, L.; Gonzalez, W; Cid, LP; Sepulveda, FV Article ISI SCOPUS BIOCHEMICAL SOCIETY TRANSACTIONS (2006)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase Ramirez A.; Heimbach, A; Gruendemann, J; Stiller, B; Hampshire, D; Cid, LP; Goebel, I; Mubaidin, AF; Wriekat, AL; Roeper, J; Al-Din, A; Hillmer, AM; Karsak, M; Liss, B; Woods, CG; Behrens, MI; Kubisch, C Article ISI SCOPUS NATURE GENETICS (2006)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Ramirez A.; Heimbach A.; Grundemann J.; Stiller B.; Hampshire D.; Cid LP.; Goebel I.; Mubaidin AF.; Wriekat AL.; Roeper J.; Al-Din A.; Hillmer AM.; Karsak M.; Liss B.; Woods CG.; Behrens MI.; Kubisch C. Article ISI NATURE GENETICS (2006)
Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain Yusef, YR; Zuniga, L.; Catalán M.; Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2006)
Two splice variants derived from a Drosophila melanogaster candidate ClC gene generate ClC-2-type Cl(-) channels Flores, CA; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS MOLECULAR MEMBRANE BIOLOGY (2006)
Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif Pena-Muzenmayer, G; Catalán M.; Cornejo I.; Figueroa, CD; Melvin, JE; Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2005)
Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies Niemeyer M.I.; Yusef Y.R.; Cornejo I.; Flores C.A.; Sepulveda, F. V.; Cid, L. P. Article SCOPUS Physiological Genomics (2005)
Putative ClC-2 chloride channel mediates inward rectification in Drosophila retinal photoreceptors Ugarte, G.; Delgado, R; O'Day, PM; Farjah, F; Cid, LP; Vergara C.; Bacigalupo, J Article ISI SCOPUS JOURNAL OF MEMBRANE BIOLOGY (2005)
The voltage-dependent CIC-2 chloride channel has a dual gating mechanism Zuniga, L.; Niemeyer, MI; Varela D.; Catalán M.; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2004)
A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the CIC-2 chloride channel Niemeyer, MI; Cid, LP; Zuniga, L.; Catalán M.; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2003)
Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity Niemeyer, MI; Cid, LP; Valenzuela, X; Sepulveda, FV Article ISI SCOPUS MOLECULAR MEMBRANE BIOLOGY (2003)
ClC-2 in guinea pig colon: mRNA, immunolabeling, and functional evidence for surface epithelium localization Catalán M.; Cornejo I.; Figueroa, CD; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)
Effect of an N-terminus deletion on voltage-dependent gating of the ClC-2 chloride channel Varela D.; Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2002)
Aquaporin-2, a regulated water channel, is expressed in apical membranes of rat distal colon epithelium Gallardo, P; Cid, LP; Vio, CP; Sepulveda, FV Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2001)
Cloning, cellular distribution and functional expression of small intestinal epithelium guinea pig C1C-5 chloride channel Cornejo I.; Niemeyer, MI; Sepulveda, FV; Cid, LP Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2001)
K+ conductance activated during regulatory volume decrease. The channels in Ehrlich cells and their possible molecular counterpart Niemeyer, MI; Cid, LP; Sepulveda, FV Article ISI Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology (2001)
Modulation of the two-pore domain acid-sensitive K+ channel TASK-2 (KCNK5) by changes in cell volume Niemeyer, MI; Cid, LP; Barros, LF; Sepulveda, FV Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Splice variants of a ClC-2 chloride channel with differing functional characteristics Cid, LP; Niemeyer, MI; Ramirez A.; Sepulveda, FV Article ISI AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2000)
Separate taurine and chloride efflux pathways activated during regulatory volume decrease Stutzin, A.; Torres, R.; Oporto, M.; Pacheco, P.; Eguiguren, A.L.; Cid, L.P.; Sepúlveda´, F.V. Article ISI AMERICAN JOURNAL OF PHYSIOLOGY (1999)
Analysis of ClC-2 channels as an alternative pathway for chloride conduction in cystic fibrosis airway cells. Schwiebert, E.M.; L. Cid; D. Stafford; M. Carter; C.J. Blaisdell; P.L. Zeitlin; W.B. Guggino; G.R. Cutting Article ISI Proc Natl Acad Sci U S A (1998)
Modulation by extracellular Cl- of volume-activated organic osmolyte and halide permeabilities in HeLa cells. Stutzin A.; Eguiguren, AL; Cid, LP; Sepúlveda FV Article ISI AMERICAN JOURNAL OF PHYSIOLOGY (1997)
Cloning of a putative human voltage - gated chloride channel (CIC-2) cDNA widely expressed in human tissues Cid L.P.; Montrose- Rafizadech C.; Smith D.I.; Guggino W.B.; Cutting G. R. Article ISI Hum. Mol. Genet. (1995)


Differences in electrogenic secretion of electrolytes in colonic epithelium of inbred mouse strains. Flores, CA; Sepulveda, FV; Cid, LP Abstract ISI FASEB JOURNAL (2009)
Basolateral ClC-2 chloride channels in surface colon epithelium: Regulation by a direct effect of intracellular chloride Catalán M.; Niemeyer, MI; Cid, LP; Sepulveda, FV Abstract ISI JOURNAL OF GENERAL PHYSIOLOGY (2003)
Effect of mutation C256A in rat ClC-2 on its gating behavior Zuniga, L.; Niemeyer, MI; Varela D.; Sepulveda, FV; Cid, LP Abstract ISI JOURNAL OF GENERAL PHYSIOLOGY (2003)
Expression of aquaporin-2 in rat distal colon: Effect of water restriction Gallardo, P; Cid, LP; Sepulveda, FV Abstract ISI FASEB JOURNAL (2001)
Characterisation of ClC-2 chloride channel splice variants Cid, LP; Ramirez A.; Niemeyer, MI; Sepulveda, FV Abstract ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)
Expression of aquaporin-2 in the rat colon: effect of thirsting Gallardo, P; Vio, CP; Cid, LP; Sepulveda, FV Abstract ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)


"Indirect identi fi cation of the TASK2 potassium channel expression by β -galactosidase activity" López-Cayuqueo, I.K.; Roa-Rojas, H.A.; Sepúlveda, F.V.; Cid, L.P. ConferencePoster (2012)


Direct G protein modulation of K2P channel TASK-2: a role for basic residues in the C-terminus domain Anazco, Carolina; Cid, Luis P.; Pena, Gaspar; Sepúlveda, Francisco V.; Niemeyer, Maria Isabel ConferenceProceedingWhole Physiology 2011 (2011)


B lymphocytes taken to task: a role for a background conductance K-2P K+ channel in B cells. Focus on "Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells" Flores, CA; Cid, LP; Niemeyer, MI; Sepulveda, FV EditorialMaterial ISI SCOPUS American Journal of Physiology - Cell Physiology (2011)
A tale from the Crypt: splice variants of BK channels in colonic potassium secretion Flores, CA; Cid, LP; Sepulveda, FV EditorialMaterial ISI SCOPUS Journal of Physiology (2010)
ClC-2 channels get new partners. Focus on Association between Hsp90 and the ClC-2 chloride channel upregulates channel function" Cid, LP; Niemeyer, MI; Sepulveda, FV EditorialMaterial ISI AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)


No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy Niemeyer, MI; Cid, LP; Sepulveda, FV; Blanz, J; Auberson, M; Jentsch, TJ Letter ISI SCOPUS Nature Genetics (2010)


EXPLORING THE POSSIBLE ROLE OF THE INWARDLY RECTIFYING K+ CHANNEL KIR7.1 IN THE CILIATED EPITHELIA OF THE CHOROID PLEXUS AND THE CILIARY BODY OF THE EYE FONDECYT (1160043) Proyecto 2016-2020 Coinvestigador(a)
CHARACTERIZATION OF THE ROLE OF KIR 7.1 POTASSIUM CHANNELS IN RENAL ELECTROLYTE TRANSPORT USING A GENETIC APPROACH. FONDECYT (1150735) Proyecto 2015-2019 Inv. Responsable
REGULATION OF TASK-2 A K2P POTASSIUM CHANNEL, BY PHOSPHOINOSIDES. FONDECYT (1140153) Proyecto 2014-2018 Coinvestigador(a)
-Identificación of potassium channels involved in sodium-coupled absorption nutrients and in the secretion of electrolytes and fluid in intestinal epithelium FONDECYT (1120743) Proyecto 2013-2016 Coinvestigador(a)
Molecular dissection to study the contribution of the intra and extracellular pH sensors of TASK-2 channels on its renal function. An experimental approach using transgenic mice to rescue the TASK-2-null phenotype Cid, Luis P.; Sepulveda, Francisco V.; Niemeyer, Maria Isabel Proyecto (2011)
MOLECULAR DISSECTION TO STUDY THE CONTRIBUTION OF THE INTRA AND EXTRACELLULAR PH SENSORS OF TASK-2 CHANNELS ON ITS RENAL FUNCTION. AN EXPERIMENTAL APPROACH USING TRANSGENIC MICE TO RESCUE THE TASK-2-NULL PHENOTYPE. FONDECYT (1110774) Proyecto 2011-2015 Inv. Responsable
Molecular dissection to study the contribution of the intra and extracellular pH sensors of TASK-2 channels on its renal function. An experimental approach using transgenic mice to rescue the TASK-2-null phenotype”. FONDECYT (1110774) Proyecto 2011-2014 Inv. Principal
-Mecanismos moleculares de regulacion del canal de potasio KCNQ1/KCNE3 por 17 beta-estradiol. FONDECYT (1100859) Proyecto 2010-2012 Coinvestigador(a)
Extracellular and intracellular sensors in the gating of TASK-2, a two-pore-domain potassium channel. FONDECYT (1090478) Proyecto 2009-2011 Coinvestigador(a)
Microdominios tisulares de pH extracelular estudiados in situ con un sensor codificado genéticamente en ratones. FONDECYT (1085291) Proyecto 2008-2010 Inv. Principal
Tissue pH microdomains of extracellular pH studied in situ with a genetically coded sensor in mice Cid, Luis P.; Sepulveda, Francisco V. Proyecto (2008)
Mecanismos moleculares del efecto dual de los protones extracelulares sobre el gating del canal de cloruro ClC-2. FONDECYT (1070722) Proyecto 2007-2009 Coinvestigador(a)
Canales de cloruro activados por calcio en el epitelio intestinal como mediadores de la secreción de fluido=> potenciales mediadores de la diarrea rotaviral y modificadores del defecto intestinal en la fibrosis quística . FONDECYT (1061069) Proyecto 2006-2008 Coinvestigador(a)
- Generación de un ratón que exprese el canal ClC -2 unido a la proteína fluorescente verde. Estudio de localización e implicaciones funcionales. FONDECYT (1051081.) Proyecto 2005-2007 Inv. Principal
Es posible revertir el sindrome de Rett? restitución condicional de mecp2 en modelos murinos para esta enfermedad. 2005-2007. Fondecyt 1051079 FONDECYT (1051079) Proyecto 2005-2007 Coinvestigador(a)
Generation of a mouse expressing the ClC-2 chloride channel coupled to the green fluorescent protein. Localization studies and functional implications Cid, Luis Pablo; Sepulveda, Francisco V. Proyecto (2005)
Estudio celular y molecular d la vía basolateral de salida de cloruro en el epitelio intestinal. FONDECYT (1030627) Proyecto 2003-2005 Coinvestigador(a)
Epilepsia idiopática generalizada=> estudio funcional de mutaciones en el gen CLCN2. FONDECYT (1020652.) Proyecto 2002-2004 Inv. Principal
Idiopathic Generalized Epilepsy: Functional studies of CLC-2 gene mutations Cid, Luis P.; Sepulveda, Francisco V. Proyecto (2002)
Mecanismo de regulación y estructura oligomérica de un canal de cloruro expresado en epitelios. 2000-2002. Fondecyt 1000622 FONDECYT (1000622) Proyecto 2000-2002 Coinvestigador(a)
Papel de los canales epiteliales de la familia ClC en la función intestinal. FONDECYT (1990939.) Proyecto 1999-2001 Inv. Principal
Role of the epithelium ClC family chloride channels in the intestinal function Cid, Luis P.; Sepulveda, Francisco V. Proyecto (1999)
Identificación molecular y caracterización funcional del canal de K+ epitelial activado por aumento del volumen celular. 1998-2001. Fondecyt 1980718 FONDECYT (1980718) Proyecto 1998-2001 Coinvestigador(a)
Clonamiento y expresión funcional de canales de cloruro ClC del epitelio intestinal. FONDECYT (1961208) Proyecto 1996-1998 Inv. Principal
Cloning and functional expression of intestinal epithelium ClC family chloride channels Cid, Luis P.; Sepulveda, Francisco V.; Del Castillo-Salomon, Jesus; Jentsch, Thomas Proyecto (1996)
Cellular and molecular studies of the basolateral via of chloride efflux in the intestinal epithelia. Sepúlveda, F.V.; Cid, Luis P.; Maria Isabel Niemeyer Proyecto (0)
Characterization of the role of Kir 7.1 potassium channels in renal electrolyte transport using a genetic approach. Cid, Luis P.; Sepulveda, Francisco V.; Cornejo, Isabel M. Proyecto (0)
Chloride channels activated by calcium in the intestinal epithelia as mediators of the fluid secretion: potential mediators of the rotavirus diarrhea and modifiers of the cystic fibrosis intestinal defect Niemeyer, Maria Isabel; Cid, Luis P.; Sepulveda, Francisco V. Proyecto (0)
Exploring the possible role of the inwardly rectifying K+ channel Kir7.1 in the ciliated epithelia of the choroid plexus and the ciliary body of the eye. Sepúlveda, Francisco V.; Cid, Luis P.; Niemeyer, Maria Isabel Proyecto (0)
Extracellular and intracellular sensors in the gating of TASK-2, two-pore-domain potassium channel. Niemeyer, Maria Isabel; Cid, Luis P.; Sepulveda, Francisco V. Proyecto (0)
Identificación of potassium channels involved in sodium-coupled absorption nutrients and in the secretion of electrolytes and fluid in intestinal epithelium Sepúlveda, Francisco V.; Cid, Luis P. Proyecto (0)
Is possible revert the Rett syndrome? conditional restitution of mecp2 gene in murine models of the disease YOUNG, JUAN I.; Cid, Luis P. Proyecto (0)
Mechanism de regulation and oligomeric structure of a chloride channel expressed in epithelia Sepúlveda, Francisco V.; Cid, Luis P.; Niemeyer, Maria Isabel Proyecto (0)
Molecular identification and molecular characterization of a potassium channel activated by cell swelling STUTZIN, ANDRES J.; Cid, Luis P.; Sepulveda, Francisco V.; Riquelme, Gloria H.; Niemeyer, Maria Isabel Proyecto (0)
Molecular mechanism of regulation of KCNQ1/KCNE3 potassium channel by 17beta-oestradiol. Sepúlveda, Francisco V.; Cid, Luis P. Proyecto (0)
Molecular mechanisms of the dual effect of the extracellular protons in the chloride channel ClC-2 gating. Sepúlveda, Francisco V.; Cid, Luis P. Proyecto (0)
Regulation of TASK-2, a K2P potassium channel, by phosphoinosides. Niemeyer, Maria Isabel; Cid, Luis P. Proyecto (0)


MOLECULAR ASPECTS OF STRUCTURE, GATING, AND PHYSIOLOGY OF pH-SENSITIVE BACKGROUND K-2P AND Kir K+-TRANSPORT CHANNELS Sepulveda, F. V.; Cid, L. P.; Teulon, J; Niemeyer M.I. Review ISI SCOPUS PHYSIOLOGICAL REVIEWS (2015)
TASK-2 K-2P K+ channel: thoughts about gating and its fitness to physiological function Lopez-Cayuqueo, KI; Pena-Munzenmayer, G; Niemeyer, MI; Sepulveda, FV; Cid, LP Review ISI SCOPUS Pflugers Archiv European Journal of Physiology (2015)
TASK-2: a K-2p K+ channel with complex regulation and diverse physiological functions Cid, L. Pablo; Roa-Rojas, Hugo A.; Niemeyer, María I.; González, Wendy; Araki, Masatake; Araki, Kimi; Sepúlveda, Francisco V. Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2013)
TMEM16 proteins: the long awaited calcium-activated chloride channels? Flores, CA; Cid, LP; Sepulveda, FV; Niemeyer, MI Review ISI SCOPUS Brazilian Journal of Medical and Biological Research (2009)

Postdoctoral

Biología

Centro de Estudios Científicos

Valdivia, Chile

Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

Sandra Villanueva

Tesista

Biología

Centro de Estudios Científicos

Valdivia, Chile

Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

Moisés Sandoval

Co-Investigador

Bioquímica y Microbiología

Universidad Austral de Chile

Valdivia, Chile

Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

Viviana Bustos

Researcher

Universidad de Los Lagos

Valdivia, Chile

Carolina Añazco

Profesora Asociada

Universidad San Sebastián

Valdivia, Chile

Bárbara Arévalo

Investigador

Líneas de Investigación

Educación

Medical Doctor, UNIVERSIDAD DE CHILE. Chile, 1982

Physiologic and Genetics, Johns Hopkins University. Estados Unidos, 1995

Magister in Cs. Physicians Mention Pathophysiology, UNIVERSIDAD DE CHILE. Chile, 2000

Experiencia Académica

Instructor Full Time

Postdoctoral Fellow Full Time

Instructor Full Time

Experiencia Profesional

Medico Full Time

Formación de Capital Humano

Difusión y Transferencia

Article (49)

Abstract (6)

ConferencePoster (1)

ConferenceProceedingWhole (1)

EditorialMaterial (3)

Letter (1)

Proyecto (37)

EXPLORING THE POSSIBLE ROLE OF THE INWARDLY RECTIFYING K+ CHANNEL KIR7.1 IN THE CILIATED EPITHELIA OF THE CHOROID PLEXUS AND THE CILIARY BODY OF THE EYE

CHARACTERIZATION OF THE ROLE OF KIR 7.1 POTASSIUM CHANNELS IN RENAL ELECTROLYTE TRANSPORT USING A GENETIC APPROACH.

REGULATION OF TASK-2 A K2P POTASSIUM CHANNEL, BY PHOSPHOINOSIDES.

-Identificación of potassium channels involved in sodium-coupled absorption nutrients and in the secretion of electrolytes and fluid in intestinal epithelium

MOLECULAR DISSECTION TO STUDY THE CONTRIBUTION OF THE INTRA AND EXTRACELLULAR PH SENSORS OF TASK-2 CHANNELS ON ITS RENAL FUNCTION. AN EXPERIMENTAL APPROACH USING TRANSGENIC MICE TO RESCUE THE TASK-2-NULL PHENOTYPE.

Molecular dissection to study the contribution of the intra and extracellular pH sensors of TASK-2 channels on its renal function. An experimental approach using transgenic mice to rescue the TASK-2-null phenotype”.

-Mecanismos moleculares de regulacion del canal de potasio KCNQ1/KCNE3 por 17 beta-estradiol.

Extracellular and intracellular sensors in the gating of TASK-2, a two-pore-domain potassium channel.

Microdominios tisulares de pH extracelular estudiados in situ con un sensor codificado genéticamente en ratones.

Mecanismos moleculares del efecto dual de los protones extracelulares sobre el gating del canal de cloruro ClC-2.

Canales de cloruro activados por calcio en el epitelio intestinal como mediadores de la secreción de fluido=> potenciales mediadores de la diarrea rotaviral y modificadores del defecto intestinal en la fibrosis quística .

- Generación de un ratón que exprese el canal ClC -2 unido a la proteína fluorescente verde. Estudio de localización e implicaciones funcionales.

Es posible revertir el sindrome de Rett? restitución condicional de mecp2 en modelos murinos para esta enfermedad. 2005-2007. Fondecyt 1051079

Estudio celular y molecular d la vía basolateral de salida de cloruro en el epitelio intestinal.

Epilepsia idiopática generalizada=> estudio funcional de mutaciones en el gen CLCN2.

Mecanismo de regulación y estructura oligomérica de un canal de cloruro expresado en epitelios. 2000-2002. Fondecyt 1000622

Papel de los canales epiteliales de la familia ClC en la función intestinal.

Identificación molecular y caracterización funcional del canal de K+ epitelial activado por aumento del volumen celular. 1998-2001. Fondecyt 1980718

Clonamiento y expresión funcional de canales de cloruro ClC del epitelio intestinal.

Review (4)