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Rafael Agustin Burgos Aguilera

FULL PROFESSOR

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

PHARMACOLOGY; INFLAMMATION, SIGNAL TRANSDUCTION, NATURAL PRODUCTS, IMMUNOPHARMACOLOGY

Master of Science in Pharmacology, UNIVERSIDAD DE CHILE. Chile, 1996
Licenciado en Ciencias Veterinarias, Universidad Austral de Chile. Chile, 1990
Medico Veterinario, Universidad Austral de Chile. Chile, 1990

Full Professor Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Veterinary Science

Valdivia, Chile

2007 - A la fecha
Assistant Professor Full Time

Universidad Austral de Chile

Veterinary Science

Valdivia, Chile

1996 - 2002
Associate Professor Full Time

UNIVERSIDAD AUSTRAL DE CHILE

Veterinary Science

Valdivia, Chile

2003 - 2007

Adjunct Professor Part Time

Universidad de Chile

Santiago, Chile

1994 - 1995

TUTOR

PhD
Angélica Hidalgo. Inhibición del factor nuclear NF-kB por labdanos diterpénicos en neutrófilos humanos. Doctorado en Ciencias Mención Biología Celular y Molecular. 2003-2005

Ivan Orlando Conejeros Espinoza. ACTIVACIÓN DE LA FUNCIÓN PRO-INFLAMATORIA EN NEUTRÓFILOS BOVINOS POR ENTRADAS CAPACITATIVAS DE CALCIO (SOCE). Doctor en Ciencias Veterinarias, Universidad Austral de Chile, 2011.

Evelyn Jara F., Delfinidina estimula la producción de interleuquina-2 (IL-2) a través de la “entrada de calcio operada por almacenamiento” (SOCE) y la activación del factor nuclear de células T activadas (NFAT). Doctor en Ciencias Mención Biología Celular y Molecular. Universidad Austral de Chile, 2012.

Daniella Carretta . Propionato induce la liberación de los gránulos del neutrófilo de bovino a través de los receptores GPR41 y GPR43. Doctor en Ciencias Mención Biología Celular y Molecular. Universidad Austral de Chile, 2013.

PhD In Progress
Pablo Alarcón. Programa Doctorado en Ciencias Mención Biología Celular y Molecular. Universidad Austral de Chile,

Jorge Hidalgo, Programa de Doctorado en Ciencias Médicas. Universidad Austral de Chile,

Carlos Contreras, Programa de Doctorado en Ciencias Veterinarias, Universidad Austral de Chile

MSc
Alvaro Sandoval Hasse
Rol de la entrada capacitativa de calico sobre la activación de MAPK y control de pH intracelular. Magister en Ciencias Mención Salud Animal, 2007

Tania Pérez Determinación Del Efecto De Andrografolido Sobre La Expresion De Cox – 2 En Linea Celular Mc3t3 – E1 De Osteoblastos Estimulados Con El Factor De Necrosis Tumoral Alfa (Tnf – ?) Y El Factor De Crecimiento Transformante (TGF – ?). Magister en Ciencias Mención Salud Animal, 2009

Paula Miranda Evaluación del efecto inmunoestimulante de andrografolido en cultivos celulares en peces salmonideos Magister en Ciencias Mención Patología Animal, Universidad Austral de Chile, 2011

Claudia Concha. Evaluación de la función de neutrófilos bovinos durante acidosis ruminal aguda por sobrecarga con oligofructosa. Magister en Ciencias Mención Salud Animal, 2013.

Daniel Herzberg. Efecto de la administración de oligofructosa como inductor de acidosis ruminal aguda y su rol en el desarrollo de laminitis bovina. Magister en Ciencias Mención Salud Animal, 2014.

Postdoc:
Pamela Erhenfeld
Anisti Loaiza
Ivan Conejeros
Carola Mattus

UNDERGRADUATE
1. Raúl Sandoval. Estudio Farmacocinético de Andrografolido en ratas tratadas con Andrographis paniculata.
2. Marcelo Imilan Evaluación del efecto miorelajador de Andrographis paniculata sobre conducto deferente de rata.
3. Marcela Aguila. Caracterización del la respuesta de Andrographis paniculata sobre el bloqueo de los canales de calcio dependiente de voltaje en musculatura lisa uterina
4. Sergio Miranda. Evaluación de un extracto liofilizado y caracterizado cromatográficamente de Stachytarpheta cayennensis sobre conducto deferente de rata.
5. Mario Loyola. Evaluación del efecto miorelajador de 14-deoxiandrografolido sobre útero de rata.
6. Sabine Matthei. Determinación de receptores del factor agregante plaquetario (PAF) mediante ensayo de radioligando en neutrófilos de bovino.
7. Juan Monsalve. Efecto de Schisandrin A, 14-deoxiandrografolido y WEB 2086 sobre la liberación de calcio intracelular inducida por el factor activante plaquetario (PAF) en neutrófilos de bovino.
8. Loreto Igor. Rl rol de la vía MAPK-NF-?B sobre el aumento de la expresión de COX-2 en células HL-60 activadas con el Factor Activante Plaquetario (PAF) y N-formil-meteonil-leucil-fenilalanina (fMLP)
9. Carlos Smith. Rol de PI3K, p38, ERK1/2 y PKC en el control de los cambios de pH intracelular inducidos por PAF en neutrófilos de bovino.
10. Alejandra Maribel Sanhueza. Rol de calcio sobre los cambios de pH intracelular y su relación con la producción de superóxido en neutrófilos de bovino.
11. Jeannette Práxedes Riquelme Miranda. Rol de calcio sobre los cambios de pH intracelular inducido por PAF en neutrófilos y su relación con la producción de superóxido.
12. Mirna Elena Perez Aguilera. Evaluación del efecto inmunosupresor del principio activo FO1024 de Andrographis paniculata en linfocitos de ratón. Karina Seguel Pobrete. Determinación del efecto inmunosupresor del principio activo FO1025 de Andrographis paniculata.
13. Triviños Castillo, Francisco Santiago Rol del calcio citosólico en las variaciones de pH intracelular inducido por propionato en neutrofilos de bovino.
14. Catalina de la Vega Giglio, Estudio de la toxicidad subcrónica del extracto de Andrographis paniculata estandarizado al 30% en andrografolido,
15. Nadia Alejandra Mesías Sánchez. Rol de MAPK en el control del pHi y producción de superóxido en células HL-60/neutrófilos inducidos por fMLP y PAF.
16. Roxana Carolina Cárdenas Catalán. Estudios de toxicidad aguda y subcrónica del extracto Andrographis paniculata al 30 en ratas Sprague Dawley.
17. Fabian Perez Niesel. Rol del calcio en la liberación de metaloproteinasa-9 en neutrófilos humanos inducido por fMLP.
18. Daniella Carretta. Efecto de andrografolido sobre el factor de transcripción NFAT en células Jurkat.
19. Diego Gallardo Memoria Titulo Medicina Veterinaria
20. Daniela Igor Memoria Titulo Medicina Veterinaria
21. Carolina Barrientos Memoria Titulo Medicina Veterinaria

PREMIO IBEROAMERICANO DE LA EXCELENCIA MÉDICA VETERINARIA

Asociación Internacional de Medicina Veterinaria IMVET

Peru, 2013

Este reconocimiento Iberoamericano es entregado por la Asociación Internacional de Medicina Veterinaria IMVET y se considera una de las más importantes distinciones que se otorga a prestigiosas instituciones y profesionales líderes del campo de la Medicina Veterinaria,


ATP Induces Interleukin-8, Intracellular Calcium Release, and ERK1/2 Phosphorylation in Bovine Endometrial Cells, Partially through P2Y Receptors Gutierrez, Noemi; Teuber, Stefanie; Alarcon, Pablo; Burgos, Rafael A. A.; Hidalgo, Maria A. Article ISI ANIMALS (2023)
Bovine tumor necrosis factor-alpha Increases IL-6, IL-8, and PGE2 in bovine fibroblast-like synoviocytes by metabolic reprogramming Manosalva, Carolina; Alarcon, Pablo; Quiroga, John; Teuber, Stefanie; Carretta, Maria D.; Bustamante, Hedie; Lopez-Munoz, Rodrigo; Hidalgo, Maria A.; Burgos, Rafael A. Article ISI SCIENTIFIC REPORTS (2023)
D-lactate-induced ETosis in cattle polymorphonuclear leucocytes is dependent on the release of mitochondrial reactive oxygen species and the PI3K/Akt/HIF-1 and GSK-38 pathways Quiroga, John; Alarcon, Pablo; Ramirez, Maria Fernanda; Manosalva, Carolina; Teuber, Stefanie; Carretta, Maria Daniella; Burgos, Rafael Agustin Article ISI DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2023)
Hydroxycarboxylic acid receptor 2 (HCA2) agonists induce NET formation and MMP-9 release from bovine polymorphonuclear leukocytes Daniella Carretta, Maria; Creutzburg, Paz; Borquez, Katherine; Quiroga, John; Alarcon, Pablo; Rivera, Andres; Agustin Burgos, Rafael Article ISI DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2023)
Ovulation Induced by Intrauterine Seminal Plasma Increases Total Protein, PGE2, IL-8, and IL-1β in Uterine Fluid of Llamas (Lama glama) Hidalgo, Alejandra Isabel; Ulloa-Leal, Cesar; Gajardo, Gonzalo; Lopez, Gerardo; Carretta, Daniella; Burgos, Rafael Agustin; Ratto, Marcelo Article ISI ANIMALS (2023)
Sodium Tungstate (NaW) Decreases Reactive Oxygen Species (ROS) Production in Cells: New Cellular Antioxidant Yanez, Alejandro J.; Jaramillo, Karen; Blana, Camila; Burgos, Rafael A.; Isla, Adolfo; Silva, Pamela; Aguilar, Marcelo Article ISI BIOMEDICINES (2023)
Tamoxifen triggers the in vitro release of neutrophil extracellular traps in healthy horses Salinas, Constanza; Barriga, Kassandra; Albornoz, Alejandro; Alarcon, Pablo; Quiroga, John; Uberti, Benjamin; Sarmiento, Jose; Henriquez, Claudio; Ehrenfeld, Pamela; Burgos, Rafael A.; Moran, Gabriel Article ISI FRONTIERS IN VETERINARY SCIENCE (2023)
D-lactate-triggered extracellular trap formation in cattle polymorphonuclear leucocytes is glucose metabolism dependent Quiroga, John; Alarcon, Pablo; Manosalva, Carolina; Teuber, Stefanie; Carretta, Maria Daniella; Burgos, Rafael Agustin Article ISI DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2022)
Evaluation of peripheral blood polymorphonuclear cell functions after an oral carbohydrate overload in obese and insulin dysregulated horses Salinas, Constanza; Espinosa, Gabriel; Morales, Natalia; Henriquez, Claudio; Moran, Gabriel; Gajardo, Gonzalo; Burgos, Rafael A.; Uberti, Benjamin Article ISI VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2022)
Glycolysis, monocarboxylate transport, and purinergic signaling are key events in Eimeria bovis-induced NETosis Conejeros, Ivan; Lopez-Osorio, Sara; Zhou, Ershun; Velasquez, Zahady D.; Del Rio, Maria Cristina; Burgos, Rafael Agustin; Alarcon, Pablo; Chaparro-Gutierrez, Jenny Jovana; Hermosilla, Carlos; Taubert, Anja Article ISI FRONTIERS IN IMMUNOLOGY (2022)
Role of Lactate in Inflammatory Processes: Friend or Foe Manosalva, Carolina; Quiroga, John; Hidalgo, Alejandra I.; Alarcon, Pablo; Anseoleaga, Nicolas; Hidalgo, Maria Angelica; Burgos, Rafael Agustin Article ISI FRONTIERS IN IMMUNOLOGY (2022)
Glycolysis and mitochondrial function regulate the radical oxygen species production induced by platelet-activating factor in bovine polymorphonuclear leukocytes Quiroga, John; Alarcón, Pablo; Manosalva, Carolina; Taubert, Anja; Hermosilla, Carlos; Hidalgo, María Angélica; Carretta, María Daniella; Burgos, Rafael Agustín Article Indexing WOS Veterinary Immunology and Immunopathology (2020)
Mitochondrial-derived ATP participates in the formation of neutrophil extracellular traps induced by platelet-activating factor through purinergic signaling in cows Quiroga, John; Alarcón, Pablo; Manosalva, Carolina; Taubert, Anja; Hermosilla, Carlos; Hidalgo, María A.; Carretta, Maria D.; Burgos, Rafael A. Article Indexing WOS/ISI DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2020)
Searching for Drug Synergy Against Cancer Through Polyamine Metabolism Impairment: Insight Into the Metabolic Effect of Indomethacin on Lung Cancer Cells LÃ³pez-Contreras F.; MuÃ±oz-Uribe M.; PÃ©rez-Laines J.; Ascencio-Leal L.; Rivera-Dictter A.; Martin-Martin A.; Burgos R.A.; Alarcon P.; LÃ³pez-MuÃ±oz R. Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2020)
Vincristine, carboplatin and cisplatin increase oxidative burst induced by PAF in canine neutrophils Mendez N.; AlarcÃ³n P.; MillÃ¡n C.; Burgos R.A.; Morera F.J.; Ojeda J. Article ISI SCOPUS (2020)
A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin (R)) on pain reduction in subjects with knee osteoarthritis Hancke, Juan L.; Srivastav, Shalini; Cáceres, Dante D.; Burgos, Rafael A. Article ISI SCOPUS PHYTOTHERAPY RESEARCH (2019)
Docosahexaenoic acid and TUG-891 activate free fatty acid-4 receptor in bovine neutrophils Olmo I.; Teuber S.; Larrazabal C.; Alarcon P.; Raipane F.; burgos R.A.; Hidalgo M. A. Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2019)
Metabolic disturbances in synovial fluid are involved in the onset of synovitis in heifers with acute ruminal acidosis Alarcon, Pablo; Hidalgo, Alejandra, I; Manosalva, Carolina; Cristi, Raul; Teuber, Stefanie; Hidalgo, Maria A.; Burgos, Rafael A. Article ISI SCOPUS SCIENTIFIC REPORTS (2019)
Pro-inflammatory mediators and neutrophils are increased in synovial fluid from heifers with acute ruminal acidosis Hidalgo A.I.; Carretta M.D.; AlarcÃ³n P.; Manosalva C.; MÃ¼ller A.; Navarro M.; Hidalgo M.A.; Kaehne T.; Taubert A.; Hermosilla C.R.; Burgos R.A. Article ISI SCOPUS BMC VETERINARY RESEARCH (2019)
Amiloride interferes with platelet-activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na+/FH+ exchanger 1 Larrazabal C.S.; Carretta M.D.; Hidalgo M.A.; Burgos R.A. Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2017)
D(-) Lactic Acid-Induced Adhesion of Bovine Neutrophils onto Endothelial Cells Is Dependent on Neutrophils Extracellular Traps Formation and CD11b Expression Alarcón P.; Manosalva C.; Conejeros I.; Carretta M.D.; Muñoz-Caro T.; Silva L.M.R.; Taubert A.; Hermosilla C.; Hidalgo M.A.; Burgos R.A. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2017)
Delphinidin Reduces Glucose Uptake in Mice Jejunal Tissue and Human Intestinal Cells Lines through FFA1/GPR40 Hidalgo J.; Teuber S.; Morera F.J.; Ojeda C.; Flores C.A.; Hidalgo M.A.; Núñez L.; Villalobos C.; Burgos R.A. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Plasma and tissue disposition of florfenicol in Escherichia coli lipopolysaccharide-induced endotoxaemic sheep Pérez-Fernández R.; Cazanga V.; Jeldres J.A.; Silva P.P.; riquelme j.; Quiroz F.; Palma C.; Carretta M.D.; Burgos R.A. Article ISI SCOPUS XENOBIOTICA (2017)
Activation of the human keratinocyte B1 bradykinin receptor induces expression and secretion of metalloproteases 2 and 9 by transactivation of epidermal growth factor receptor Matus, Carola E.; Ehrenfeld, Pamela; Pavicic, Francisca; González, Carlos B.; Concha, Miguel; Bhoola, Kanti D.; Burgos, Rafael A.; Figueroa, Carlos D. Article ISI SCOPUS EXPERIMENTAL DERMATOLOGY (2016)
Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study Bertoglio, JC; Baumgartner, M; Palma, R; Ciampi, E; Carcamo, C; Caceres, DD; Acosta-Jamett, G; Hancke, JL; Burgos, RA Article ISI SCOPUS BMC NEUROLOGY (2016)
Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor Carretta M.D.; Hidalgo A.I.; Burgos, J; Opazo, L; Castro L.; Hidalgo M. A.; Figueroa C.D.; Taubert, A; Hermosilla, C; burgos R.A. Article ISI SCOPUS Veterinary Immunology and Immunopathology (2016)
Differential free fatty acid receptor-1 (FFAR1/GPR40) signalling is associated with gene expression or gelatinase granule release in bovine neutrophils Mena, S. J.; Manosalva, C.; Carretta, M. D.; Teuber, S.; Olmo, I.; Burgos, R. A.; Hidalgo, M. A. Article ISI SCOPUS INNATE IMMUNITY (2016)
Differential intracellular calcium influx, nitric oxide production, ICAM-1 and IL8 expression in primary bovine endothelial cells exposed to nonesterified fatty acids. Loaiza, Anitsi; Carretta, María D; Taubert, Anja; Hermosilla, Carlos; Hidalgo, María A; Burgos, Rafael A Article BMC veterinary research (2016)
Differential intracellular calcium influx, nitric oxide production, ICAM-1 and IL8 expression in primary bovine endothelial cells exposed to nonesterified fatty acids. Loaiza, Anitsi; Carretta, María D; Taubert, Anja; Hermosilla, Carlos; Hidalgo, María A; Burgos, Rafael A Article BMC veterinary research (2016)
Differential intracellular calcium influx, nitric oxide production, ICAM-1 and IL8 expression in primary bovine endothelial cells exposed to nonesterified fatty acids. Loaiza, Anitsi; Carretta, María D; Taubert, Anja; Hermosilla, Carlos; Hidalgo, María A; Burgos, Rafael A Article BMC veterinary research (2016)
Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo Silva, Liliana M. R.; Muñoz-Caro, Tamara; Burgos, Rafael A.; Hidalgo, Maria A.; Taubert, Anja; Hermosilla, Carlos Article ISI SCOPUS MEDIATORS OF INFLAMMATION (2016)
Haematological and blood biochemical changes induced by the administration of low doses of Escherichia coli lipopolysaccharide in rabbits Penailillo, AK; Sepulveda, MA; Palma, CJ; Espinoza, A; Aguilera, M; Burgos, RA; Carretta, D; Islas, A; Perez, R Article WOS ARCHIVOS DE MEDICINA VETERINARIA (2016)
The acute phase response induced by Escherichia coli lipopolysaccharide modifies the pharmacokinetics and metabolism of florfenicol in rabbits Perez, R; Palma C.; Burgos, R; Jeldres, JA; Espinoza, A.; Penailillo, AK Article ISI SCOPUS JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS (2016)
Cloning, Identification and Functional Characterization of Bovine Free Fatty Acid Receptor-1 (FFAR1/GPR40) in Neutrophils Manosalva C.; Mena, J.; Velasquez, Z; Colenso, CK; Brauchi, S.; Burgos, RA; Hidalgo, MA Article ISI SCOPUS PLOS ONE (2015)
Effect of the synthetic Toll-like receptor ligands LPS, Pam(3)CSK(4), HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils Conejeros I.; Gibson, AJ; Werling, D; Munoz-Caro, T; Hermosilla, C; Taubert, A; Burgos, RA Article ISI SCOPUS Developmental & Comparative Immunology (2015)
Eimeria bovis-triggered neutrophil extracellular trap formation is CD11b-, ERK 1/2-, p38 MAP kinase- and SOCE-dependent Muñoz-Caro, Tamara; Mena Huertas, Sandra Jaqueline; Conejeros, Ivan; Alarcón, Pablo; Hidalgo, María A; Burgos, Rafael A.; Hermosilla, Carlos; Taubert, Anja Article ISI VETERINARY RESEARCH (2015)
fMLP-Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils. Hidalgo, María A; Carretta, María D; Teuber, Stefanie E; Zárate, Cristian; Cárcamo, Leonardo; Concha, Ilona I; Burgos, Rafael A Article Journal of immunology research (2015)
fMLP-Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils. Hidalgo, María A; Carretta, María D; Teuber, Stefanie E; Zárate, Cristian; Cárcamo, Leonardo; Concha, Ilona I; Burgos, Rafael A Article Journal of immunology research (2015)
fMLP-Induced IL-8 Release Is Dependent on NADPH Oxidase in Human Neutrophils. Hidalgo, MA; Carretta, MD; Teuber, SE; Zarate, C; Cárcamo, L; Concha, II; Burgos, RA Article WOS JOURNAL OF IMMUNOLOGY RESEARCH (2015)
Kinin B1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1. Figueroa, Carlos D; Matus, Carola E; Pavicic, Francisca; Sarmiento, Jose; Hidalgo, Maria A; Burgos, Rafael A; Gonzalez, Carlos B; Bhoola, Kanti D; Ehrenfeld, Pamela Article Innate immunity (2015)
Decreased cyclooxygenase-2 gene expression and lactoferrin release in blood neutrophils of heifers during the calving period Hidalgo MA, Loncomán CA, Hidalgo AI, Andrade V, Carretta MD, Burgos RA. Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2014)
Delphinidin Activates NFAT and Induces IL-2 Production Through SOCE in T Cells Jara, E; Hidalgo, MA; Hancke, JL; Hidalgo, AI; Brauchi, S.; Nuñez L.; Villalobos C.; Burgos, RA Article ISI SCOPUS CELL BIOCHEMISTRY AND BIOPHYSICS (2014)
Kinin B1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1. Figueroa, CD; Matus, CE; Pavicic, F.; Sarmiento J.; Hidalgo, MA; Burgos, RA; Gonzalez, CB; Bhoola, KD; Ehrenfeld, P Article WOS INNATE IMMUNITY (2014)
Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers Concha, Claudia; Carretta, María Daniella; Alarcón, Pablo; Conejeros, Ivan; Gallardo, Diego; Hidalgo, Alejandra Isabel; Tadich, Nestor; Cáceres, Dante Daniel; Hidalgo, María Angélica; Burgos, Rafael Agustín Article ISI SCOPUS JOURNAL OF VETERINARY SCIENCE (2014)
Use of hypometabolic TRIS extenders and high cooling rate refrigeration for cryopreservation of stallion sperm: Presence and sensitivity of 5' AMP-activated protein kinase (AMPK) Cordova A.; Strobel P.; Vallejo A.; Valenzuela P.; Ulloa, O.; Burgos, RA; Menarim, B; Rodriguez-Gil, JE; Ratto M.; Ramirez-Reveco, A Article ISI SCOPUS CRYOBIOLOGY (2014)
Inhibition of Cholinergic Contractions of Rat Ileum by Tropane-Type Alkaloids Present in Schizanthus hookeri Morales, MA; Ahumada F.; Castillo E.; Burgos, R; Christen P.; Bustos, V; Muñoz, O. Article ISI ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES (2013)
Linoleic acid increases adhesion, chemotaxis, granule release, intracellular calcium mobilisation, MAPK phosphorylation and gene expression in bovine neutrophils Mena, J.; Manosalva C.; Ramirez R.; Chandia, L; Carroza, D.; Loaiza A.; Burgos, RA; Hidalgo, MA Article ISI SCOPUS Veterinary Immunology and Immunopathology (2013)
Propionate induces the release of granules from bovine neutrophils Carretta, MD; Conejeros I.; Hidalgo, MA; Burgos, RA Article ISI SCOPUS JOURNAL OF DAIRY SCIENCE (2013)
2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils Conejeros I.; Velasquez Z.D.; Carretta M.D.; Alarcón P.; Hidalgo M. A.; burgos R.A. Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2012)
2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11 b expression, and increases L-selectin shedding in bovine neutrophils Conejeros I.; Jara, E; Carretta M.D.; Alarcón P.; Hidalgo M. A.; burgos R.A. Article ISI SCOPUS RESEARCH IN VETERINARY SCIENCE (2012)
Activation of kinin B-1 receptor increases the release of metalloproteases-2 and-9 from both estrogen-sensitive and -insensitive breast cancer cells Ehrenfeld, Ingrid; Conejeros, Ivan; Pavicic, Maria; Matus, Carola; Gonzalez, Carlos; Quest, andrew; Bhoola, Daya Article ISI SCOPUS CANCER LETTERS (2011)
D-Lactic acid interferes with the effects of platelet activating factor on bovine neutrophils Alarcón P.; Conejeros I.; Carretta, MD; Concha, C; Jara, E; Tadich, N; Hidalgo, MA; Burgos, RA Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2011)
Effects of aristotelia chilensis berry juice on cyclooxygenase 2 expression, NF-?B, NFAT, ERK1/2 and PI3K/Akt activation in colon cancer cells Efecto de un concentrado del fruto de aristotelia chilensis sobre la expresión de cicloxigenasa 2, NF-k{cyrillic}B, NFAT, ERK1/2 y activación de PI3K/Akt en células de cancer de colon Ojeda J.; Jara, E; Molina, L; Parada, F; burgos R.A.; Hidalgo M. A.; Hancke J.L. Article BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2011)
Hypoglycemic effect of lupin seed gamma-conglutin in experimental animals and healthy human subjects BERTOGLIO, JC; Calvo MA; Hancke, JL; Burgos, RA; Riva, A; Morazzoni, P.; Ponzone C.; Magni, C; Duranti M. Article ISI SCOPUS Fitoterapia (2011)
Induction of reactive oxygen species in bovine neutrophils is CD11b, but not dectin-1-dependent Conejeros I.; burgos R.A.; Patterson R.; Hermosilla, C; Werling, D Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2011)
Oleic acid induces intracellular calcium mobilization, MAPK phosphorylation, superoxide production and granule release in bovine neutrophils Hidalgo, MA; Nahuelpan, C; Manosalva C.; Jara, E; Carretta, MD; Conejeros I.; Loaiza A.; Chihuailaf, R; Burgos, RA Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Detection of reaginic antibodies against Faenia rectivirgula from the serum of horses affected with Recurrent Airway Obstruction by an in vitro bioassay Moran G.; Folch H.; Araya O.; Burgos, R; Barria, M. Article ISI SCOPUS Veterinary Research Communications (2010)
In vitro bioassay to detect reaginic antibodies from the serum of horses affected with Recurrent Airway Obstruction Moran G.; Burgos, R; Araya O.; Folch H. Article ISI SCOPUS Veterinary Research Communications (2010)
Acute and subchronic toxicological study of senna in rodents Toxicología aguda y subcrónica de una pasta de sen en roedores Hancke, J; burgos R.A.; Caceres D.; Morales, M.A.; Hernandez, D; Rojas A. Article BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS (2009)
Andrographolide reduces IL-2 production in T-cells by interfering with NFAT and MAPK activation Carretta, MD; Alarcón P.; Jara, E; Solís L.; Hancke, JL; Concha, II; Hidalgo, MA; Burgos, RA Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACOLOGY (2009)
Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial Burgos, RA; Hancke, JL; BERTOGLIO, JC; Aguirre V.; Arriagada S.; Calvo M.; Caceres, DD Article ISI SCOPUS CLINICAL RHEUMATOLOGY (2009)
Kinin B-1 receptor activation turns on exocytosis of matrix metalloprotease-9 and myeloperoxidase in human neutrophils: involvement of mitogen-activated protein kinase family Ehrenfeld, P; Matus, CE; Pavicic, F.; Toledo C.; Nualart, F.; Gonzalez, CB; Burgos, RA; Bhoola, KD; Figueroa, CD Article ISI SCOPUS JOURNAL OF LEUKOCYTE BIOLOGY (2009)
Stimulation of the bradykinin B-1 receptor induces the proliferation of estrogen-sensitive breast cancer cells and activates the ERK1/2 signaling pathway Molina, L; Matus, CE; Astroza, A; Pavicic, F.; Tapia, E; Toledo C.; Perez, JA; Nualart, F.; Gonzalez, CB; Burgos, RA; Figueroa, CD; Ehrenfeld, P; Poblete MT Article ISI SCOPUS BREAST CANCER RESEARCH AND TREATMENT (2009)
Propionate induces pH((i)) changes through calcium flux, ERK1/2, p38, and PKC in bovine neutrophils Sandoval A.; Trivinos, E; Sanhueza, A; Carretta, D; Hidalgo, MA; Hancke, JL; Burgos, RA Article ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2007)
Store-operated calcium entry mediates intracellular alkalinization, ERK1/2, and Akt/PKB phosphorylation in bovine neutrophils Sandoval, AJ; Riquelme, JP; Carretta, MD; Hancke, JL; Hidalgo, MA; Burgos, RA Article ISI SCOPUS JOURNAL OF LEUKOCYTE BIOLOGY (2007)
Activation of kinin B-1 receptors induces chemotaxis of human neutrophils Ehrenfeld, P; Millán C; Matus, CE; Figueroa JE; Burgos, RA; Nualart, F.; Bhoola, KD; Figueroa, CD Article ISI SCOPUS JOURNAL OF LEUKOCYTE BIOLOGY (2006)
14-Deoxyandrographolide as a platelet activating factor antagonist in bovine neutrophils Burgos, RA; Hidalgo, MA; Monsalve, J; LaBranche, TP; Eyre, P; Hancke, JL Article ISI SCOPUS PLANTA MEDICA (2005)
Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis Burgos, RA; Seguel, K; Perez M.; Meneses A.; Ortega M.; Guarda, MI; Loaiza A.; Hancke, JL Article ISI SCOPUS PLANTA MEDICA (2005)
Andrographolide interferes with binding of nuclear factor-kappa B to DNA in HL-60-derived neutrophilic cells Hidalgo, MA; Romero A.; Figueroa J.; Cortes P.; Concha, II; Hancke, JL; Burgos, RA Article ISI SCOPUS BRITISH JOURNAL OF PHARMACOLOGY (2005)
Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse Iruretagoyena, MI; Tobar, JA; Gonzalez PA; Sepulveda, SE; Figueroa, CA; Burgos, RA; Hancke, JL; Kalergis, AM Article ISI SCOPUS JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Determination of specific receptor sites for platelet activating factor in bovine neutrophils Burgos, RA; Hidalgo, MA; Matthei, SM; Hermosilla, R; Folch H.; Hancke, JL Article ISI SCOPUS AMERICAN JOURNAL OF VETERINARY RESEARCH (2004)
Platelet-activating factor increases pH((i)) in bovine neutrophils through the PI3K-ERK1/2 pathway Hidalgo, MA; Ojeda, F; Eyre, P; LaBranche, TP; Smith C.; Hancke, JL; Burgos, RA Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2004)
Effect of 14-deoxyandrographolide on calcium-mediated rat uterine smooth muscle contractility Burgos, RA; Loyola, M; Hidalgo, MA; LaBranche, TP; Hancke, JL Article ISI SCOPUS PHYTOTHERAPY RESEARCH (2003)
Andrographis paniculata (Ness) induces relaxation of uterus by blocking voltage operated calcium channels and inhibits Ca+2 influx Burgos, RA; Aguila, MJ; Santiesteban, ET; Sanchez, NS; Hancke, JL Article ISI SCOPUS PHYTOTHERAPY RESEARCH (2001)
Andrographis paniculata (Nees) selectively blocks voltage-operated calcium channels in rat vas deferens Burgos, RA; Imilan, M; Sanchez, NS; Hancke, JL Article ISI SCOPUS JOURNAL OF ETHNOPHARMACOLOGY (2000)
Schisandra chinensis (Turcz.) Baill Hancke, JL; Burgos, RA; Ahumada, F Article WOS FITOTERAPIA (1999)
Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study Cáceres D.D.; Hancke J.L.; burgos R.A.; Sandberg F.; Wikman G.K. Article PHYTOMEDICINE (1999)
Hepatotoxic effect of Aralia mandshurica dried root extract in pigs burgos R.A.; Cáceres D.D.; Wilkman G.; Hancke J.L.; Fuenzalida H. Article PHYTOTHERAPY RESEARCH (1997)
Non-abortive effect of Adhatoda vasica spissum leaf extract by oral administration in rats Burgos, R; Hancke, J; Wikman, G; Forcelledo M.; Croxatto H.; Wagner H.; MULLER, A Article PHYTOMEDICINE (1997)
Prevention of common colds with Andrographis paniculata dried extract. A pilot double blind trial Hancke J.L.; burgos R.A.; Wikman G.K.; Cáceres D.D. Article PHYTOMEDICINE (1997)
Testicular toxicity assesment of Andrographis paniculata dried extract in rats burgos R.A.; Caballero E.E.; Sanchez N.S.; Schroeder R.A.; Hancke J.L.; Wikman G.K. Article JOURNAL OF ETHNOPHARMACOLOGY (1997)
Reduction of serum hepatic transaminases and CPK in sport horses with poor performance treated with a standardized Schizandra chinensis fruit extract Hancke, J; Burgos, R; Caceres D.; Brunetti F.; Durigon A.; Wikman, G Article PHYTOMEDICINE (1996)
A Double Blind Study With a New Monodrug: Kan Jang Decrease of Symptoms and Enhancement of Resistance to Common Colds. Phytother. Res. 9: 559-562, 1995. Hancke, Jl; Burgos, RA; Cáceres DD; Wikman, G Article WOS PHYTOTHERAPY RESEARCH (1995)
Hypothalamic changes in norepinephrine release in rats with estradiol valerate-induced polycystic ovaries. Luza, SM,; Lizama, l; Burgos, RA; Lara, HE Article WOS BIOLOGY OF REPRODUCTION (1995)
Toxicological Assesment of Aralia mandshurica (Araliaceae) Root Extract after Subchronic Administration in Rats Burgos, R; Hancke, Jl; Wikman, G; Caballero, E; Oyarzo, M; Sanchez, N Article WOS PHYTOTHERAPY RESEARCH (1994)
New Potential Targets to Modulate Neutrophil Function in Inflammation Burgos, RA; Hidalgo, MA; Figueroa, CD; Conejeros I.; Hancke, JL Article WOS core selection index MINI-REVIEWS IN MEDICINAL CHEMISTRY


Efficacy, safety, and tolerability of IB-MS versus placebo in patients with progressive forms of MS: Preliminary results from a phase II, randomized, placebo-controlled, double blind, proof-of-concept study Ciampi, E; Hancke, J; Burgos, R; Vasquez, M; Reyes, A; Reyes, D; Pinto, C; Carcamo, C Abstract ISI MULTIPLE SCLEROSIS JOURNAL (2019)
Changes in pharmacokinetics and metabolism of florfenicol during the acute phase response induced by Escherichia coli lipopolysaccharide, in rabbits Perez, R; Palma C.; Jeldres, JA; Espinoza, A.; Burgos, R; Penailillo, A Abstract ISI JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS (2015)
OLEIC ACID INDUCES DEGRANULATION, REACTIVE OXYGEN SPECIES RELEASE AND CD11B EXPRESSION DEPENDENT OF INTRACELLULAR CALCIUM IN NEUTROPHILS Hidalgo, MA; Nahuelpan, C; Jara, E; Carretta, D; Moraga, U; Loaiza A.; Conejeros I.; Chihuailaf, R; Burgos, R Abstract INFLAMMATION RESEARCH (2011)


Indirect Measurement of CRAC Channel Activity Using NFAT Nuclear Translocation by Flow Cytometry in Jurkat Cells Carretta, MD; Hidalgo, MA; Burgos, RA; Penna, Aubin; Constantin, Bruno BookSection (2018)
Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease, Hidalgo, María A; Hancke, Juan L.; Bertoglio, Juan C.; Burgos, Rafael A.; Matsuno, Hiroaki BookSection (2014)


Combination therapy with interferon and andrographolides for Multiple Sclerosis Hancke, J; Burgos, R Patent United States Patent (2015)
Composition of labdane diterpenes extracted from andrographis paniculata, useful for the treatment of autoimmune diseases, and alzheimer disease by activation for PPR-gamma receptors Burgos, Rafael A. Patent (2011)


. D (-) lactic acid triggers Fibroblast-Like Synoviocytes activity, a hallmark in the pathophysiology of neutrophilic polysynovitis in cattle with acute ruminal acidosis. Burgos, Rafael Agustín; Hidalgo, María A; Manosalva, Carolina Proyecto (2018)
D (-) lactic acid triggers Fibroblast-Like Synoviocytes activity, a hallmark in the pathophysiology of neutrophilic polysynovitis in cattle with acute ruminal acidosis. Maria Angelica Hidalgo; Carolina Manosalva; Daniella Carretta; Manuel Moroni Proyecto (2018)
Development of a boar semen cryopreservation medium by modulating oxidative/nitrosative stress and neutrophil extracellular traps (NETs): Impact on sperm function and reproductive outcome Raul Sanchez; Rafael Burgos Proyecto (2018)
EFFECTS OF TAMOXIFEN ON PRO-RESOLUTIVE MECHANISMS OF INFLAMMATION IN HORSES WITH RECURRENT AIRWAY OBSTRUCTION FONDECYT (1160352) Proyecto 2016-2019 Coinvestigador(a)
MULTI-TARGET THERAPEUTICS IN LUNG CANCER=> POLYAMINE PATHWAY INTERVENTION INCREASES THE CHEMOTHERAPY OPPORTUNITIES AGAINST TUMOR CELLS FONDECYT (1160807) Proyecto 2016-2020 Coinvestigador(a)
LONG CHAIN FATTY ACIDS AS MODULATORS OF BOVINE INNATE IMMUNITY. ROLE OF FREE FATTY ACID (FFA)-1 AND FFA4 RECEPTORS. FONDECYT (1151047) Proyecto 2015-2018 Coinvestigador(a)
DESARROLLO DE UN BIOMARCADOR EN SANGRE COMO INDICADOR DE LA FUNCION METABOLICA INMUNE EN VACAS LECHERAS FONDEF (ID14I10050) Proyecto 2014-2017 Subdirector(a)
5. Effects of the Fever Induced by Escherichia Coli Lipopolysacharide on Plasma Disposition and Tissue Distribution of Florfenicol and Ivermectin in Sheep and Rabbits Ruben Perez; Rafael A Burgos Proyecto (2013)
EFFECTS OF THE FEVER INDUCED BY ESCHERICHIA COLI LIPOPOLYSACHARIDE ON PLASMA DISPOSITION AND TISSUE DISTRIBUTION OF FLORFENICOL AND IVERMECTIN IN SHEEP AND RABBITS. FONDECYT (1130473) Proyecto 2013-2016 Coinvestigador(a)
Implementación de un laboratorio de lipidómica para el estudio de transtornos metabólicos de ácidos grasos en ganado de producción FONDEQUIP (EQM130257) Proyecto 2013-2014 Inv. Responsable
Investigación Aplicada de un Extracto de Fruto de Maqui para el control de la glicemia en pacientes con Diabetes tipo II INNOVA CORFO 12IDL2-16254 Proyecto 2013-2015 Director(a)
Studies on Neutrophil Extracellular Traps (NET) as innate immune reactions against Eimeria spp. in vitro and in vivo. DFG TA291/4-1 (TA291/4-1) Proyecto 2013-2015 Coinvestigador(a)
D-lactataemia increases the bovine blood neutrophil activity and is associated with the early onset of laminitis in heifer with acute ruminal acidosis FONDECYT (1120718) Proyecto 2012-2015 Director(a)
ROLE OF NEUTROPHILS IN THE ONSET OF BOVINE LAMINITIS. STUDY OF ACIDOSIS AS NEUTROPHILS PRIMING INDUCER AGENT. FONDECYT (1090401) Proyecto 2009-2012 Director(a)
EVALUACION DE LA EFICACIA INMUNOMODULADORA DE UNA COMPOSICION DE LABDANOS DITERPENICOS Y DESARROLLO DE NUEVOS ANALOGOS SINTETICOS FONDEF (D04I1240) Proyecto 2004-2006 Director(a)
ACTIVIDAD ANTI-INFLAMATORIA DE 14-DEOXIANDROGRAFOLIDO EN BOVINOS. POSIBLE ROL ANTAGONISTA DEL RECEPTOR DE PAF. FONDECYT (1010204) Proyecto 2001-2004 Inv. Principal
EVALUACION Y DESARROLLO DE UN NUEVO INMUNOESTIMULANTE DE ORIGEN NATURAL FONDEF (D01I1024) Proyecto 2001-2003 Subdirector(a)
Actividad anti-inflamatoria de 14-deoxiandrografolido en bovino. Posible rol antagonista del receptor de PAF Burgos, Rafael A.; Hancke, Juan L. Proyecto (0)
D-lactataemia increases the bovine blood neutrophil activity and is associated with the early onset of laminitis in heifer with acute ruminal acidosis Burgos, Rafael A.; Hidalgo, María A Proyecto (0)
EVALUACION DE LA EFICACIA INMUNOMODULADORA DE UNA COMPOSICION DE LABDANOS DITERPENICOS Y DESARROLLO DE NUEVOS ANALOGOS SINTETICOS Burgos, Rafael A.; Hancke, Juan L. Proyecto (0)
mplementación de un laboratorio de lipidómica para el estudio de transtornos metabólicos de ácidos grasos en ganado de producción Burgos, Rafael A.; Hidalgo, María A Proyecto (0)
ROLE OF NEUTROPHILS IN THE ONSET OF BOVINE LAMINITIS. STUDY OF ACIDOSIS AS NEUTROPHILS PRIMING INDUCER AGENT Burgos, Rafael A.; Hidalgo, María A Proyecto (0)
Studies on Neutrophil Extracellular Traps (NET) as innate immune reactions against Eimeria spp. in vitro and in vivo Taubert, Anja; Burgos, Rafael A. Proyecto (0)


Fatty and hydroxycarboxylic acid receptors: The missing link of immune response and metabolism in cattle Alarcon, P; Manosalva C.; Carretta, MD; Hidalgo, AI; Figueroa, CD; Taubert, A; Herrnosilla, C; Hidalgo, MA; Burgos, RA Review ISI SCOPUS VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2018)

100

Rafael Burgos

FULL PROFESSOR

PHARMACOLOGY AND MORPHOPHYSIOLOGY

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

MARIA HIDALGO

Associate professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

María Carretta

Assistant Professor

Faculty of Veterinary Science

Universidad Austral de Chile

valdivia, Chile

Evelyn Jara

Docente/Investigador

Ciencias Básicas

Universidad Santo Tomás

Temuco, Chile

Pablo Alarcón

Profesor a honorarios

CFT Santo Tomas

valdivia, Chile

DANTE CACERES

Académico

Programa de Salud Ambiental

ESCUELA DE SALUD PUBLICA, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Ivan Conejeros

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

INGRID EHRENFELD

FULL PROFESSOR

ANATOMIA; HISTOLOGIA & PATOLOGIA

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

Carlos Figueroa

Head

Anatomy, Histology and Pathology

Universidad Austral de Chile

Valdivia, Chile

FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

Hugo Folch

Professor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Pablo González

Associate Professor

Molecular Genetics and MIcrobiology

Pontificia Universidad Católica de Chile

Santiago, Chile

Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

Cesar Toledo

Estudiante de posgrado Doctorado en Ciencias Agropecuarias

Ciencias Agropecuarias y Acuícolas

Universidad Católica de Temuco

Temuco, Chile

Gabriel Moran

Associate Professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Maria Poblete

Profesor Auxiliar

Anatomia, Histologia y Patologia

Universidad Austral de Chile

Valdivia, Chile

MARIO CALVO

Profesor Asociado

Instituto de Medicina

UNIVERSIDAD AUSTRAL DE CHILE

VALDIVIA, Chile

Marcelo Ratto

Profesor titular

Ciencia Animal

Universidad Austral de Chile

Valdivia, Chile

César Ulloa

Docente Tiempo Completo

Ciencia Animal

Universidad Austral de Chile

Valdivia, Chile

Pablo Strobel

Prrofesional de laboratorio

Facultad Ciencias Veterinarias

Universidad Austral de Chile

Valdivia, Chile

Claudio Figueroa

Profesor Asistente

Ciencias Biológicas y Quimicas

Universidad San Sebastian

Santiago, Chile

Ricardo Chihuailaf

Académico

Instituto de Ciencias Clínicas Veterinarias

Universidad Austral de Chile

Valdivia, Chile

Luis Molina

PROFESOR ASISTENTE

CIENCIAS BÁSICAS

Universidad San Sebastián

Puerto Montt, Chile

Jorge Hidalgo

Profesor Auxiliar

Instituto de Medicina

Universidad Austral de Chile

Valdivia, Chile

Carolina Manosalva

Académico Auxiliar categoría 03

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Carlos Flores

Researcher

Biology Lab

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

Armando Rojas

Profesor Titular, Director de Laboratorio Investigaciones Biomédicas

Ciencias Preclínicas

FACULTAD DE MEDICINA, UNIVERSIDAD CATOLICA DEL MAULE

Talca, Chile

Ilona Concha

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

Alfredo Ramírez

Profesor Asociado

Instituto de Ciencia Animal

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Javier Ojeda

Docente instructor en el INstituto de Ciencias Clínicas Veterinarias.

Universidad Austral de Chile

Valdivia, Chile

Francisco Morera

Assistant Professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Johanna Burgos

Postdoctoral

Biología

Centro de Estudios Científicos

Valdivia, Chile

Rodrigo Lopez

Profesor Asociado

Facultad de Ciencias Veterinarias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Viviana Bustos

Researcher

Universidad de Los Lagos

Valdivia, Chile

Lucas Opazo

Postdoctoral Fellow

Renal, Vascular and Diabetes Research Lab

Instituto de Investigación Sanitaria Fundación Jiménez Díaz

Madrid, España

Pamela Silva

Lab Manager

Facultad de Ciencias

Universidad Austral de Chile

Valdivia, Chile

Carola Millan

Profesor

de Ciencias

UNIVERSIDAD ADOLFO IBAÑEZ FACULTAD DE ARTES LIBERALES

Viña del Mar, Chile

Jaime Figueroa

Profesor Titular

Bioquimica y Microbiologia

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Alex Romero

Profesor Asociado

Facultad de Ciencias Veterinarias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Rafael Agustin Burgos Aguilera

Líneas de Investigación

Educación

Master of Science in Pharmacology, UNIVERSIDAD DE CHILE. Chile, 1996

Licenciado en Ciencias Veterinarias, Universidad Austral de Chile. Chile, 1990

Medico Veterinario, Universidad Austral de Chile. Chile, 1990

Experiencia Académica

Full Professor Full Time

Assistant Professor Full Time

Associate Professor Full Time

Experiencia Profesional

Adjunct Professor Part Time

Formación de Capital Humano

Premios y Distinciones

PREMIO IBEROAMERICANO DE LA EXCELENCIA MÉDICA VETERINARIA

Article (86)

Abstract (3)

BookSection (2)

Patent (2)

Proyecto (23)

EFFECTS OF TAMOXIFEN ON PRO-RESOLUTIVE MECHANISMS OF INFLAMMATION IN HORSES WITH RECURRENT AIRWAY OBSTRUCTION

MULTI-TARGET THERAPEUTICS IN LUNG CANCER=> POLYAMINE PATHWAY INTERVENTION INCREASES THE CHEMOTHERAPY OPPORTUNITIES AGAINST TUMOR CELLS

LONG CHAIN FATTY ACIDS AS MODULATORS OF BOVINE INNATE IMMUNITY. ROLE OF FREE FATTY ACID (FFA)-1 AND FFA4 RECEPTORS.

DESARROLLO DE UN BIOMARCADOR EN SANGRE COMO INDICADOR DE LA FUNCION METABOLICA INMUNE EN VACAS LECHERAS

EFFECTS OF THE FEVER INDUCED BY ESCHERICHIA COLI LIPOPOLYSACHARIDE ON PLASMA DISPOSITION AND TISSUE DISTRIBUTION OF FLORFENICOL AND IVERMECTIN IN SHEEP AND RABBITS.

Implementación de un laboratorio de lipidómica para el estudio de transtornos metabólicos de ácidos grasos en ganado de producción

Investigación Aplicada de un Extracto de Fruto de Maqui para el control de la glicemia en pacientes con Diabetes tipo II

Studies on Neutrophil Extracellular Traps (NET) as innate immune reactions against Eimeria spp. in vitro and in vivo.

D-lactataemia increases the bovine blood neutrophil activity and is associated with the early onset of laminitis in heifer with acute ruminal acidosis

ROLE OF NEUTROPHILS IN THE ONSET OF BOVINE LAMINITIS. STUDY OF ACIDOSIS AS NEUTROPHILS PRIMING INDUCER AGENT.

EVALUACION DE LA EFICACIA INMUNOMODULADORA DE UNA COMPOSICION DE LABDANOS DITERPENICOS Y DESARROLLO DE NUEVOS ANALOGOS SINTETICOS

ACTIVIDAD ANTI-INFLAMATORIA DE 14-DEOXIANDROGRAFOLIDO EN BOVINOS. POSIBLE ROL ANTAGONISTA DEL RECEPTOR DE PAF.

EVALUACION Y DESARROLLO DE UN NUEVO INMUNOESTIMULANTE DE ORIGEN NATURAL

Review (1)