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Ricardo Alfredo Tapia Apati

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Heterocyclic Chemistry, Medicinal Chemistry, Organic Synthesis

Organic Chemitry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1981
Quimica Organica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1981

Full Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chemistry

Santiago, Chile

1971 - 2010
Full Professor Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chemistry

Santiago, Chile

2017 - A la fecha
Profesor Titular Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Quimica

Santiago, Chile

2011 - 2016

Quimico Other

CGM Nuclear

Santiago, Chile

2004 - 2005

TEACHING: ADVANCED ORGANIC SYNTHESIS
PhD Theses Directed: CLAUDIO SAITZ BARRIA (PhD 1991); CARMINA QUINTANAR SANTIBAÑEZ (PhD 1994); MIRIAM GARATE VIDAL (PhD 1997); YOLANDA PRIETO LARA (PhD 2002); LUZ ALEGRIA AGUIRRE (PhD 2002); CRISTIAN SALAS SANCHEZ (PhD 2005); CLAUDIO LOPEZ ASTORGA (PhD 2005); LORENA CANTUARIAS BOTTERO (PhD 2009)
PhD Theses Co-Directed: CHRISTIAN ESPINOSA BUSTOS (PhD 2013); ANDREA CERDA MONJE (PhD 2013); MANUEL A. ESCOBAR (PhD 2014).
Current Graduate Students:
DAVID MORENO DA COSTA (2010- )
CLAUDIA LOPEZ LIRA (2012- )
PATRICIO SANCHEZ (2013- )
Postdoctoral Fellows: FRANCISCO ARMIJO (2008-2010); GONZALO RECABARREN (2008-2010) ALVARO CAÑETE (2008-2010); JORGE SOTO DELGADO (2013- )


An efficient and eco-friendly method for the thiol-Michael addition in aqueous solutions using amino acid ionic liquids (AAILs) as organocatalysts Figueroa GuÃÃ±ez R.; Santos J.G.; Tapia, R.A.; Alcazar J.J.; Aliaga M.E.; Pavez P. Article ISI SCOPUS The Scientific Journal of IUPAC (2020)
Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays Salas, C. O.; Zarate A.M.; KryÅ¡tof V.; Mella J.; Faundez M.; Brea J.; Loza M.I.; Brito I.; HendrychovÃ¡ D.; Jorda R.; Cabrera A.R.; Tapia, R.A.; Espinosa-Bustos C. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Supercritical carbon dioxide solubility in hydrophobic ionic liquid mixtures: Experimental determination and thermodynamic modeling Ormazábal, S.; Villarroel, E.; Tapia, R.A.; Romero, J.; Quijada-Maldonado, E. Article Fluid Phase Equilibria (2020)
Design, synthesis, cytotoxicity and 3D-QSAR analysis of new 3,6-disubstituted-1,2,4,5-tetrazine derivatives as potential antitumor agents Canete-Molina, A; Espinosa-Bustos, C; Gonzalez-Castro, M; Faundez, M; Mella, J; Tapia, RA; Cabrera, AR; Brito, I; Aguirre, A; Salas, CO Article ISI ARABIAN JOURNAL OF CHEMISTRY (2019)
Thermal storage density of ionic liquid mixtures: A preliminary study as thermal fluid Mora, Sebastián; Neculqueo, Gloria; Tapia, Ricardo A.; Urzúa, Julio I. Article ISI SCOPUS JOURNAL OF MOLECULAR LIQUIDS (2019)
Activation of Electrophile/Nucleophile Pair by a Nucleophilic and Electrophilic Solvation in a SNAr Reaction Sanchez, Bruno; Calderon, Cristian; Tapia, Ricardo A.; Contreras, Renato; Campodonico, Paola R. Article ISI SCOPUS FRONTIERS IN CHEMISTRY (2018)
Dual function of amino acid ionic liquids (Bmim[AA]) on the degradation of the organophosphorus pesticide, Paraoxon® Morales J.I.; Figueroa R.; Rojas M.; MillÃ¡n D.; Tapia, R.A.; Pavez P. Article ISI SCOPUS (2018)
Effect of the nature of the nucleophile and solvent on an SNAr reaction Gazitua, M; Tapia, RA; Contreras, R; Campodonico, PR Article ISI SCOPUS NEW JOURNAL OF CHEMISTRY (2018)
Synthesis and characterization of poly (ionic liquid) derivatives of N -alkyl quaternized poly(4-vinylpyridine) Ximena Briones, O.; Tapia, Ricardo A.; Campodonico, Paola R.; Urzua, Marcela; Leiva, Angel; Contreras, Renato; Gonzalez-Navarrete, Javier Article ISI SCOPUS REACTIVE FUNCTIONAL POLYMERS (2018)
Task-Specific Ionic Liquids as Extractants for the Solvent Extraction of Molybdenum(VI) from Aqueous Solution Using Different Commercial Ionic Liquids as Diluents Quijada-Maldonado, E; Sanchez, F; Perez, B; Tapia, R; Romero, J Article ISI SCOPUS INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2018)
A New Approach to the Synthesis of Benzo[b]naphtho[2,3-b]furan-6,11-diones and 2-Benzyl-3-hydroxynaphthalene-1,4-diones Barcia, JC; Cruces, J; Salas, CO; Estevez, JC; Cuellar, MA; Tapia, RA; Estevez, RJ Article WOS-ESCI SYNOPEN (2017)
Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor Romero-Parra, Javier; Chung, Hery; Tapia, Ricardo A.; Faúndez, Mario; Morales-Verdejo, Cesar; Lorca, Marcos; Lagos, Carlos F.; Di Marzo, Vincenzo; David Pessoa-Mahana, C.; Mella, Jaime Article ISI SCOPUS EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)
Mechanism for the SNAr reaction of atrazine with endogenous thiols: experimental and theoretical study Calfuman, K; Gallardo-Fuentes, S; Contreras, R; Tapia, RA; Campodonico, PR Article ISI SCOPUS New Journal of Chemistry (2017)
Structural analysis and molecular docking of trypanocidal aryloxy-quinones in trypanothione and glutathione reductases: a comparison with biochemical data Vera, Brenda; Vazquez, Karina; Tapia, Ricardo A.; Mascayano, Carolina; Espinosa, Victoria; Soto-Delgado, Jorge; Salas, Cristian O.; Paulino, Margot Article ISI SCOPUS JOURNAL OF BIOMOLECULAR STRUCTURE DYNAMICS (2017)
Multiscale Treatment for the Molecular Mechanism of a Diels−Alder Reaction in Solution: A QM/MM-MD Study Soto-Delgado, Jorge; Tapia, Ricardo A.; Torras, Juan Article ISI JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2016)
Gutmann’s Donor Numbers Correctly Assess the Effect of the Solvent on the Kinetics of SNAr Reactions in Ionic Liquids Alarcon-Esposito, Jazmin; Contreras, Renato; Tapia, Ricardo A.; Campodonico, Paola R. Article ISI CHEMISTRY-A EUROPEAN JOURNAL (2016)
Highly sensitive determination of vanadium (V) by catalytic adsorptive stripping voltammetry. Substituent effect on sensitivity III Rojas-Romo, C; Arancibia, V; Moreno Da Costa D.; Tapia, RA Article ISI SCOPUS SENSORS AND ACTUATORS B-CHEMICAL (2016)
N-Heterocyclic carbene copper(I) complex- catalyzed synthesis of 2-aryl benzoxazoles and benzothiazoles Urzua, Julio I.; Contreras, Renato; Salas, Cristian O.; Tapia, Ricardo A. Article ISI RSC ADVANCES (2016)
Changes in the SNAr reaction mechanism brought about by preferential solvation Alarcon-Esposito, J; Tapia, RA; Contreras R.; Campodonico, PR Article ISI SCOPUS JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2015)
Design, Synthesis, Biological Evaluation and Binding Mode Modeling of Benzimidazole Derivatives Targeting the Cannabinoid Receptor Type 1 Espinosa-Bustos, C; Lagos, C. F.; Romero-Parra J.; Zarate A.M.; Mella-Raipan J.; Pessoa-Mahana H.; Recabarren-Gajardo G.; Iturriaga-Vasquez, P; Tapia, R.A.; Pessoa-Mahana C.D. Article ISI SCOPUS ARCHIV DER PHARMAZIE (2015)
Lewis Acid Enhanced Ethene Dimerization and Alkene Isomerization-ESI-MS Identification of the Catalytically Active Pyridyldimethoxybenzimidazole Nickel(II) Hydride Species Escobar, Manuel A.; Trofymchuk, Oleksandra S.; Rodriguez, Barbara E.; Lopez-Lira, Claudia; Tapia, Ricardo; Daniliuc, Constantin; Berke, Heinz; Nachtigall, Fabiane M.; Santos, Leonardo S.; Rojas, Rene S. Article ISI SCOPUS ACS Catalysis (2015)
Lewis Acid Enhanced Ethene Dimerization and Alkene IsomerizationESI-MS Identification of the Catalytically Active Pyridyldimethoxybenzimidazole Nickel(II) Hydride Species Escobar, Manuel A.; Trofymchuk, Oleksandra S.; Rodriguez, Barbara E.; Lopez-Lira, Claudia; Tapia, Ricardo; Daniliuc, Constantin; Berke, Heinz; Nachtigall, Fabiane M.; Santos, Leonardo S.; Rojas, René S. Article ISI ACS CATALYSIS (2015)
New aryloxy-quinone derivatives as potential anti- Chagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis Vazquez, Karina; Espinosa-Bustos, Christian; Soto-Delgado, Jorge; Tapia, Ricardo A.; Varela, Javier; Birriel, Estefania; Segura, Rodrigo; Pizarro, Jaime; Cerecetto, Hugo; Gonzalez, Mercedes; Paulino, Margot; Salas, Cristian O. Article ISI RSC ADVANCES (2015)
New aryloxy-quinone derivatives as potential antiChagasic agents: synthesis, trypanosomicidal activity, electrochemical properties, pharmacophore elucidation and 3D-QSAR analysis Vazquez, K; Espinosa-Bustos, C; Soto-Delgado, J; Tapia, RA; Varela, J; Birriel, E; Segura, R; Pizarro J.; Cerecetto, H.; Gonzalez, M.; Paulino M.; Salas, CO Article ISI SCOPUS JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2015)
Synthesis and pharmacophore modelling of 2,6,9-trisubstituted purine derivatives and their potential role as apoptosis-inducing agents in cancer cell lines Calderón-Arancibia, Jeannette; Espinosa-Bustos, Christian; Cañete-Molina, Alvaro; Tapia, Ricardo A.; Faundez, Mario; Torres, Maria J.; Aguirre, Adam; Paulino, Margot; Salas, Cristian O. Article ISI MOLECULES (2015)
Synthesis and Pharmacophore Modelling of 2,6,9-Trisubstituted Purine Derivatives and Their Potential Role as Apoptosis-Inducing Agents in Cancer Cell Lines Calderon-Arancibia, J; Espinosa-Bustos, C; Canete-Molina, A; Tapia, RA; Faundez, M; Torres, MJ; Aguirre A.; Paulino M.; Salas, CO Article ISI SCOPUS MOLECULES (2015)
2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities Sieveking, Ivan; Thomas, Pablo; Estevez, Juan C.; Quinones, Natalia; Cuellar, Mauricio A.; Villena, Juan; Espinosa-Bustos, Christian; Fierro, Angelica; Maya, Juan D.; Lopez-Munoz, Rodrigo; Cassels, Bruce K.; Estevez, Ramon J.; Salas, Cristian O. Article ISI SCOPUS (2014)
Mechanistic pathways of aromatic nucleophilic substitution in conventional solvents and ionic liquids Gazitua M.; Tapia, R.A.; Contreras R.; Campodónico, P. R. Article ISI SCOPUS NEW JOURNAL OF CHEMISTRY (2014)
Site activation effects promoted by intramolecular hydrogen bond interactions in SNAr reactions Gallardo-Fuentes, S; Tapia, R.A.; Contreras R.; Campodónico, P. R. Article ISI SCOPUS RSC ADVANCES (2014)
Synthesis and biological characterization of new aryloxyindole-4,9-diones as potent trypanosomicidal agents Tapia, RA; Salas, CO; Vazquez, K; Espinosa-Bustos, C; Soto-Delgado, J; Varela, J; Birriel, E; Cerecetto, H.; Gonzalez, M.; Paulino M. Article ISI SCOPUS BIOORGANIC MEDICINAL CHEMISTRY LETTERS (2014)
Copper(I) complexes bases on a new indazol-4,7-dione ligand Escobar, MA; Jara, DH; Tapia, RA; Lemus L.; Frohlich, R; Guerrero, J; Rojas, RS Article ISI SCOPUS POLYHEDRON (2013)
Lewis Molecular Acidity of Ionic Liquids from Empirical Energy− Density Models Contreras, Renato; Aizman, Arie; Tapia, Ricardo A.; Cerda-Monje, Andrea Article ISI Journal Physical Chemistry B (2013)
Mechanism of Pyrogallol Red Oxidation Induced by Free Radicals and Reactive Oxidant Species. A Kinetic and Spectroelectrochemistry Study Atala E.; Velásquez G; Vergara C.; Mardones, C.; Reyes, J; Tapia, RA; Quina, F; Mendes, MA; Speisky H.; Lissi E.; Ureta-Zanartu, MS; Aspée A.; Lopez-Alarcon, C Article ISI SCOPUS JOURNAL OF PHYSICAL CHEMISTRY B (2013)
New Short Strategy for the Synthesis of the Dibenz[b,f]oxepin Scaffold Moreno, DRR; Giorgio, G; Salas, CO; Tapia, RA Article ISI SCOPUS MOLECULES (2013)
Novel 1-(1-benzyl-1H-indol-3-yl)-N,N,Ntrimethylmethanaminium iodides are competitive antagonists for the human a4b2 and a7 nicotinic acetylcholine receptors Perez, Edwin G.; Ocampo, Cristian; Feuerbach, Dominik; Lopez, Jhon J.; Morelo, Guibeth L.; Tapia, Ricardo A.; Arias, Hugo R. Article ISI Medicinal Chemistry Communications (2013)
Specific nucleophile–electrophile interactions in nucleophilic aromatic substitutions Ormazábal-Toledo, Rodrigo; Contreras, Renato; Tapia, Ricardo A.; Campodonico, Paola R. Article ISI ORGANIC & BIOMOLECULAR CHEMISTRY (2013)
Theoretical study on the molecular mechanism of the [5+2] vs. [4+2] cyclization mediated by Lewis acid in the quinone system Soto-Delgado, J; Saez, JA; Tapia, RA; Domingo, LR Article ISI SCOPUS ORGANIC AND BIOMOLECULAR CHEMISTRY (2013)
BIOLOGICAL ACTIVITIES AND CORRELATIONS TENDENCY OF ELECTROCHEMICAL PROPERTIES OF SOME INDOLIZINO[1,2-B]QUINOLINE DERIVATIVES Cañete Á.; armijo, F; del Valle, MA; Tapia, RA; Theoduloz, C; Pessoa, CD; Cantuarias L; Recabarren, G Article ISI JOURNAL OF THE CHILEAN CHEMICAL SOCIETY (2012)
Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione Lagos, C. F.; Araya-Secchi R.; Thomas P.; Perez-Acle, T; Tapia, R.A.; Salas, C. O. Article ISI SCOPUS JOURNAL OF MOLECULAR MODELING (2012)
Solvent effects in ionic liquids: empirical linear energy-density relationships Cerda-Monje, A; Aizman A.; Tapia, R.A.; Chiappe, C.; Contreras R. Article ISI SCOPUS PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2012)
Solvent effects in ionic liquids: empirical linear energy–density relationships Cerda-Monje, Andrea; Aizman, Arie; Tapia, Ricardo A.; Chiappe, Cinthia; Contreras, Renato Article ISI Phys. Chem. Chem. Phys (2012)
6,9-Dimethoxy-3,4-dihydro-1H-1,4-oxazino[4,3-a ]indol-1- one Salas, Cristian O.; Tapia, Ricardo A.; Prieto, Yolanda Article ISI Acta Cryst. E (2011)
Adsorption Behavior of Hydrophobically Modified Polyelectrolytes onto Amino- or Methyl-Terminated Surfaces Briones, XG; Encinas, MV; Petri, DFS; Pavez, JE; Tapia, RA; Yazdani-Pedram, M; Urzua, MD Article ISI SCOPUS Langmuir (2011)
Electrochemistry behavior of endogenous thiols on fluorine doped tin oxide electrodes Rojas, L.; Molero, L.; Tapia, RA; Del Rio R.; del Valle, MA; Antilen, M; armijo, F Article ISI SCOPUS Electrochimica Acta (2011)
NL MIND-BEST: A web server for ligands and proteins discovery-Theoretic-experimental study of proteins of Giardia lamblia and new compounds active against Plasmodium falciparum Gonzalez-Diaz, H; Prado-Prado F.; Sobarzo-Sanchez, E; Haddad M.; Chevalley, SM; Valentin A.; Quetin-Leclercq, J; Dea-Ayuela, MA; Gomez-Munos, MT; Munteanu, CR; Torres-Labandeira, JJ; Garcia-Mera X.; Tapia, RA; Ubeira, FM Article ISI SCOPUS Journal of Theoretical Biology (2011)
Synthesis, characterization, and electrochemical studies of new 5-and 6-nitro N-acyl-1H-indazoles Recabarren-Gajardo G.; Gacitua, M; Murueva I.; Romero J.; Espinosa-Bustos, C; Mella-Raipan J.; del Valle, MA; Pessoa-Mahana, CD; Tapia, R Article ISI SCOPUS JOURNAL OF PHYSICAL ORGANIC CHEMISTRY (2011)
(Z)-Ethyl 2-phenyl-1-(2-vinylphenyl)vinylcarbamates. Part 1: Synthesis and preliminary studies on their divergent transformation into benzo[c]phenanthridines and 2-phenyl-1,4-naphthoquinones Treus, M; Salas, CO; Gonazalez, MA; Estevez, JC; Tapia, RA; Estevez, RJ Article ISI SCOPUS Tetrahedron (2010)
7-(tert -Butyldiphenylsilyloxy)-2,2-dimethyl-1-benzofuran- 3(2H)-one Salas, Cristian O.; Tapia, Ricardo A.; Macias, Alejandro Article ISI Acta Cryst. E (2010)
Captopril electrochemical oxidation on fluorine-doped SnO2 electrodes and their determination in pharmaceutical preparations Armijo, F.; Torres, I.; Tapia, R.; Molero, L.; Antilen, M.; del Río,R.; del Valle, M. A.; Ramírez, G. Article Electroanal (2010)
Copper Bromide-Catalyzed C-Alkylation of 2-Amino-1,4-Naphthoquinone: New Synthesis of 1-Azaanthraquinones Tapia, RA; Venegas J.; Cantuarias, LB Article ISI SCOPUS Synthetic Communications (2010)
New Approaches to 6-Oxoisoaporphine and Tetrahydroisoquinoline Derivatives Sobarzo-Sanchez, E.; Uriarteb, E.; Santana, L.; Tapia, R. A.; Lourido, P. P. Article Helvetica Chimica Acta (2010)
New approaches to 6-oxoisoaporphine and tetrahydroisoquinoline derivatives Sobarzo-SÃ¡nchez E.; Uriarte, E; Santana, L; Tapia, R.A.; Lourido P.P. Article ISI SCOPUS Helvetica Chimica Acta (2010)
New approaches to 6-oxoisoaporphine and tetrahydroisoquinoline derivatives Sobarzo-Sanchez, E. Uriarte, E.; Santana, L.; R. Tapia, R. A.; P. P. Lourido, P. P. Article Helv. Chim. Acta (2010)
Gold-Facilitated '6-Exo-dig' Intramolecular Cyclization of 2-[(2-Nitrophenyl)ethynyl]phenylacetic Acids: General Access to 5H-Benzo[b]carbazole-6,11-diones Salas, CO; Reboredo, FJ; Estevez, JC; Tapia, RA; Estevez, RJ Article ISI SCOPUS SYNLETT (2009)
Microwave-Assisted Reaction of 2,3-Dichloronaphthoquinone with Aminopyridines Tapia, Ricardo A.; Cantuarias, Lorena; Cuellar, Mauricio A.; Villena, Juan Article ISI Journal of Brazilian Chemistry (2009)


BIO-BASED IONIC LIQUIDS AND SURFACE-ACTIVE BIO-BASED IONIC LIQUIDS AS REACTION MEDIA FOR DEGRADATION OF ORGANOPHOSPHORATED PESTICIDES Pavez, Paulina; Tapia, Ricardo A. Proyecto (2017)
Design, synthesis and biological impact of new smooothened anatagonists as potent hedgehog signaling inhibitors in pancreatic cancer FONDECYT (1161816) Proyecto 2016-2019 Coinvestigador(a)
DESIGN, SYNTHESIS AND BIOLOGICAL IMPACT OF NEW SMOOTHENED ANTAGONISTS AS POTENT HEDGEHOG SIGNALING INHIBITORS IN PANCREATIC CANCER Salas, Cristian O.; Tapia, Ricardo A. Proyecto (2016)
BENZIMIDAZOLEQUINONES AND BIOISOSTERES AS ANTI-CHAGASIC AGENT: TRYPANOCIDAL EFFECT, SELECTIVITY AND 3D-QSAR STUDIES Tapia, Ricardo A.; Salas, Cristian O.; Soto-Delgado, Jorge Proyecto (2015)
BENZIMIDAZOLEQUINONES AND BIOISOSTERES AS ANTI-CHAGASIC AGENT=> TRYPANOCIDAL EFFECT, SELECTIVITY AND 3D-QSAR STUDIES FONDECYT (1150307) Proyecto 2015-2017 Inv. Responsable
Nucleo Milenio. Renovación Centro de Investigación en Líquidos Iónicos Santiago=> CILIS Fondo de Innovacion para la Competitividad del Ministerio de Economı´a, Fomento y Turismo, Chile (RC-130006 CILIS) Proyecto 2015-2017 Investigador(a)
DESIGN AND SYNTHESIS OF SMALL MOLECULES WITH POTENTIAL OSTEOGENESIS-INDUCING ACTIVITY IN MESENCHYMAL STEM CELLS. A CHEMICAL APROACH TO BONE REGENERATIVE MEDICINE. FONDECYT (1120128) Proyecto 2012-2016 Coinvestigador(a)
THEORETICAL STUDY OF THE HETERO-DIELS-ALDER REACTIONS IN DIFFERENT REACTIONS MEDIA FONDECYT (3130359) Proyecto 2012-2015 Inv. Patrocinante
Nucleo Milenio. Centro de Investigación en Líquidos Iónicos Santiago=> CILIS Fondo de Innovación para la Competitividad del Ministerio de Economía, Fomento y Turismo, Chile (ICM-P10-003-F) Proyecto 2011-2013 Investigador(a)
ESTUDIO DE OBTENCION DE QUINONAS POLICICLICAS DERIVADAS DE BENZOTHIAZINO- Y PIRIDOINDOLOQUINONAS. FONDECYT (1060592) Proyecto 2006-2010 Inv. Responsable
SINTESIS Y ACTIVIDAD ANTITUMORAL DE QUINONAS ANGULARES N-HETEROCICLICAS. FONDECYT (1060591) Proyecto 2006-2010 Coinvestigador(a)


Natural and Synthetic Naphthoquinones Active Against Trypanosoma Cruzi: An Initial Step Towards New Drugs for Chagas Disease Salas, CO; Faundez, M; Morello A.; Maya, JD; Tapia, RA Review ISI SCOPUS Current Medicinal Chemistry (2011)

Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Cristian Salas

Associate professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Renato Contreras

professor

Quimica

Universidad de Chile

Santiago, Chile

Paola Campodonico

Director of Centro de Química Médica and Associate Professor

CENTRE OF MEDICINAL CHEMISTRY, FACULTY OF MEDICINE, UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

Marcela Urzúa

Associate Professor

Chemistry

UNIVERSIDAD DE CHILE

Santiago, Chile

Maria Encinas

Full Professor

Enviroment Science

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Ximena Briones

UNIVERSIDAD DEL DESARROLLO

SANTIAGO, Chile

Javier Romero

Profesor Asistente

Departamento de Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

Alvaro Cañete

Profesor-investigador

instituto de ciencias químicas aplicadas

Universidad Autónoma de Chile

Santiago, Chile

Juan Maya

Full Professor

Biomedical Sciences Institute

UNIVERSIDAD DE CHILE

Santiago, Chile

Juan Armijo

Asociado

Inorgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

JORGE PAVEZ

Professor

Materials Chemistry

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Mehrdad Yazdani-Pedram

Académico Profesor Titular

Organic and Physical Chemistry

Universidad de Chile

Santiago, Chile

ANA ZÁRATE

investigadora

Químca-Física

Pontificia Universidad Católica de Chile

Santiago, Chile

Rene Rojas

Professor

Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Manuel Escobar

Jefe de Proyectos Investigación y Desarrollo

Investigación y desarrollo

Upcycle SpA

Santiago, Chile

Rodrigo del Rio

associate professor

inorganic chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FACULTAD DE QUIMICA, DPTO QUIMICA INORGANICA

santiago, Chile

Carlos Pessoa

Profesor Titular

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Veronica Arancibia

Profesor horas

Quimica Inorganica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Angel Leiva

Full Professor

Physical Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Fabiane Manke

Académico Docente Investigador

Universidad Autónoma de Chile

Talca, Chile

Christian Espinosa

Postdoctorando

Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

cristian calderon

inestigador/profesor

Centro de Química Medica

Universidad del Desarollo

Santiago, Chile

Julio Urzúa

Director

Center for Materials for Energy Transition and Sustainability

Chilean Nuclear Energy Commission

Santiago, Chile

Bárbara Rodríguez

Académica/Investigadora

Centro de Investigación en Recursos Naturales y Sustentabilidad

Universidad Bernardo O'Higgins

Santiago, Chile

RODRIGO SEGURA

Academico

DEPARTAMENTO DE QUIMICA DE LOS MATERIALES

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Elias Atala

Head of Science & Technology

R & D

Q-VANT Bioscience

Santiago, Chile

LEONARDO SILVA

PROFESOR TITULAR

UNIVERSIDAD DE TALCA

TALCA, Chile

Carlos Rojas

Profesor Asistente

Departamento de Química

Universidad de Chile

Santiago, Chile

Margarita Aliaga

Associate Professor

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Daniela Millan

Academico investigador

Centro integrativo de biologia y quimica aplicada

Universidad Bernardo O'Higgins

Santiago, Chile

Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

Alan Cabrera

Profesor Asistente

Departamento de Química Inorganica

Pontificia Universidad Católica de Chile

Santiago, Chile

Camilo López

prof. Asociado

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

ALEXIS ASPEE

Profesor Titular

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Maria Soledad Ureta

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Hernan Speisky

PROFESOR TITULAR

UNIVERSITY OF CHILE

SANTIAGO, Chile

Claudia Mardones

Académica

Departamento Análisis Instrumental

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Carola Vergara

Profesor Asociado

Departamento de Análisis Instrumental

Universidad de Concepción

Concepcion, Chile

Juan Guerrero

ACADEMICO

QUÍMICA DE LOS MATERIALES

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Luis Lemus

PROFESOR ASOCIADO

FACULTAD DE QUIMICA Y BIOLOGIA

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

HERNAN PESSOA

Profesor Asociado

Química Orgánica y Fisicoquímica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Raul Araya

Docente Investigador

Facultad de Ingenieria y Tecnologia

Universidad San Sebastián

Santiago, Chile

Sebastian Gallardo

Profesor colaborador

UNIVERSIDAD DE CHILE

Santiago, Chile

María José Torres

Docente

Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

Claudia López

Investigador Asociado

Food Science and Technology

The Ohio State University

Columbus, Estados Unidos

Javiera Morales

Académica / Coordinadora de Investigación

Facultad de ciencias de la salud

Universidad Bernardo O'Higgins

Santiago, Chile

Jaime Pizarro

Postdoctorando

Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile

MONICA ANTILEN

Profesor Asociado

quimica Inorganica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Oleksandra Trofymchuk

assistant professor

Universidad de Chile

Santaigo, Chile

Manuel Gacitúa

Profesor asistente

Departamento de Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile

Gonzalo Recabarren

Académico

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Ricardo Alfredo Tapia Apati

Líneas de Investigación

Educación

Organic Chemitry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1981

Quimica Organica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1981

Experiencia Académica

Full Professor Full Time

Full Professor Part Time

Profesor Titular Part Time

Experiencia Profesional

Quimico Other

Formación de Capital Humano

Article (55)

Proyecto (11)

Design, synthesis and biological impact of new smooothened anatagonists as potent hedgehog signaling inhibitors in pancreatic cancer

BENZIMIDAZOLEQUINONES AND BIOISOSTERES AS ANTI-CHAGASIC AGENT=> TRYPANOCIDAL EFFECT, SELECTIVITY AND 3D-QSAR STUDIES

Nucleo Milenio. Renovación Centro de Investigación en Líquidos Iónicos Santiago=> CILIS

DESIGN AND SYNTHESIS OF SMALL MOLECULES WITH POTENTIAL OSTEOGENESIS-INDUCING ACTIVITY IN MESENCHYMAL STEM CELLS. A CHEMICAL APROACH TO BONE REGENERATIVE MEDICINE.

THEORETICAL STUDY OF THE HETERO-DIELS-ALDER REACTIONS IN DIFFERENT REACTIONS MEDIA

Nucleo Milenio. Centro de Investigación en Líquidos Iónicos Santiago=> CILIS

ESTUDIO DE OBTENCION DE QUINONAS POLICICLICAS DERIVADAS DE BENZOTHIAZINO- Y PIRIDOINDOLOQUINONAS.

SINTESIS Y ACTIVIDAD ANTITUMORAL DE QUINONAS ANGULARES N-HETEROCICLICAS.

Review (1)