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Alvaro Fernando Lladser Caldera

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

Study of antitumor immunity, in particular CD8+ T cells, and harnessing this knowledge to design strategies promoting tumor elimination.

Biochemist, UNIVERSIDAD DE CHILE. Chile, 2001
Biochemistry, UNIVERSIDAD DE CHILE. Chile, 1999
Inmunología, UNIVERSIDAD DE CHILE. Chile, 2007

Principal Investigator, Laboratory of Immunoncology Full Time

FUNDACION CIENCIA PARA LA VIDA

Santiago, Chile

2010 - A la fecha
Postdoctoral Investigator Full Time

KAROLINSKA INSTITUTE

Cancer Center Karolinska

Stockholm, Suecia

2007 - 2010

Undergraduate student Full Time

Gene Pharmacotherapy Lab, Faculty of Chemical and Pharmaceutical, Universidad de Chile

Chile

2000 - 2001
Research Assistant Full Time

Gene Pharmacotherapy Lab, Faculty of Chemical and Pharmaceutical Sciences , Universidad de Chile

Chile

2002 - 2002
Graduate student Full Time

Cell comunication Lab, Faculty of Medicine, Universidad de Chile

Chile

2004 - 2007
Postdoctoral investigator Full Time

Cancer Center Karolinska (CCK), Karolinska Institutet

Suecia

2007 - 2010
Principal Investigator Full Time

Fundación Ciencia para la Vida

Chile

2010 - A la fecha

RESEARCH GRANTS
2025-2021 Principal Investigator FONDECYT Regular Grant 1212070.
2021-2010 Principal Investigator Basal Funding Program AFB 170004 to Fundación Ciencia & Vida
2022-2018 Co-Investigator FONDECYT Regular Grant 1180385. PI: Dr. Daniela Sauma.
2021-2017 Principal Investigator FONDECYT Regular Grant 1171703.
2018-2017 Principal Investigator FONDEF IDeA ID16I10369.
2017-2013 Co-Investigator FONDECYT Regular Grant 1130271. PI: Dr. Rodrigo Pacheco.
2016-2012 Principal Investigator CORFO-Innova L2 I+D Aplicada 12IDL2-13348.
2016-2012 Sponsor Investigator FONDECYT Postdoctoral Grant 3130764.
2016-2012 Co-Investigator CORFO-Innova L2 I+D Aplicada 12IDL2-16030. PI: Dr. Rodrigo Pacheco
2014-2011 Principal Investigator FONDECYT Starting Grant 11110525.
2014-2011 Principal Investigator CONICYT Insertion in the Academy Grant 791100038.

PEER REVIEW PANELS
2020-2019 Director Study Group FONDECYT “Biology 2”
2018-2017 Member Study Group FONDECYT “Biology 2”
2014-2013 Reviewer committee FONDEF grants
Since 2020 Reviewer for Nature Communications
Since 2020 Reviewer for Journal for ImmunoTherapy of Cancer
2015-2021 Associate Editor for Human Vaccines & Immunotherapeutics

MEMBERSHIPS
Since 2019 Vice-President ASOCHIN – Asociación Chilena de Inmunología.
Since 2018 Member EATI – European Academy of Tumor Immunology
Since 2017 Member ASOCHIN – Asociación Chilena de Inmunología.
Since 2017 Member SBCCH – Sociedad de Biología Celular de Chile

POSTDOCTORAL SUPERVISION
Since 2021 Dr. Farides Saavedra
2016-2012 Dr. Paola Murgas. Postdoctoral FONDECYT Grant 3130764.
2012-2011 Dr. Andrés Herrada.

THESIS SUPERVISION
Finished PhD Theses
2019 Evelyn Menares. PhD in Biotechnology, Universidad Andrés Bello.
2018 Felipe Gálvez. PhD in Biotechnology, Universidad Andrés Bello.
2016 Nicole Rojas. PhD in Biotechnology, Universidad Andrés Bello.
2015 César Oyarce. PhD in Biomedical Sciences, Universidad de Chile.
2015 Maarten Ligtenberg. PhD in Medical Sciences, Karolinska Institute. Sweden.

Ongoing PhD Theses
Since 2018 Sofia Hidalgo. PhD in Biotechnology, Universidad Andrés Bello.
Since 2019 Diego Figueroa. PhD in Biotechnology, Universidad Andrés Bello.

Finished Magister Theses

2020 Nicolás Méndez. Magister in Biotechnology, Universidad Andrés Bello.
2019 Pablo Cáceres. Magister in Biochemistry, Universidad de Chile.
2018 Ornella Chovar. Magister in Biological Sciences, Universidad de Chile.
2016 Ernesto López. Magister in Biological Sciences, Universidad de Chile.
2017 Luis Mourgues. Magister in Biotechnology, Universidad Andrés Bello.
2017 Sebastián Cruz. Magister in Biochemistry, Universidad de Chile.
2016 Eduardo Durán. Magister in Biochemistry, Universidad de Concepción.
2014 Nicolás Bustamante. Magister in Biological Sciences, Universidad de Chile.

Ongoing Magister Thesis

Since 2020 Francisca Hofmann. Magister in Biotechnology, Universidad Andrés Bello.

Finished Undergraduate Theses
2019 Juan Saavedra. Engineering in Molecular Biotechnology, Universidad de Chile.
2019 Javiera Gómez. Biochemistry, Universidad de Santiago de Chile.
2016 Ernesto López. Engineering in Molecular Biotechnology, Universidad de Chile.
2016 Camila Flores. Engineering in Molecular Biotechnology, Universidad de Chile.
2016 Nicole Araya. Biotechnology, Universidad Mayor.
2016 Felipe Gálvez. Pharmaceutical Chemistry, Universidad de Chile.
2014 Sebastián Cruz. Biology, Pontificia Universidad Católica de Valparaíso.
2012 Jonathan Roco. Biochemistry, Pontificia Universidad Católica de Chile.
2012 Paula González. Biotechnology, Universidad de la Frontera.

Ongoing Undergraduate Theses
2020 Brian Sirguiado. Engineering in Biotechnology, Universidad Andrés Bello.
2020 Pablo Contreras. Engineering in Biotechnology, Universidad Andrés Bello.

Participation in Opinion Leader Workshop, 2012 - 2015. Moderator Biotechnology Session at Encounters Chile Global, Santiago. 2014 “Biomedicina, una carrera contra el tiempo: desde la idea al paciente” ("Biomedicine, a race against time: from idea to patient")

OUTREACH & MEDIA

2020 Interview in television channel Mega Plus, program Mundo Plus, (February 2020)
Url: https://www.lun.com/Pages/NewsDetail.aspx?dt=2019-10-01&NewsID=437320&BodyID=0&PaginaId=8
2020 Interview in online radio program TXS Health in TxS Radio (February 2020)
Url: https://youtu.be/sejFpoxkKLU
2019 Article in national newspaper LUN (1 October 2019)
Url: https://www.lun.com/Pages/NewsDetail.aspx?dt=2019-10-01&NewsID=437320&BodyID=0&PaginaId=8
2018 Program in national television channel 24 Horas (28 November 2018)
Url: https://www.24horas.cl/programas/exploradores/exploradores---miercoles-28-de-noviembre-2897898
2018 Report in national television newscast at Chilevision about the 2018 Nobel Prize (1 October 2018)
Url: https://www.futuro360.com/data/padres-de-la-inmunoterapia-contra-el-cancer-son-ganadores-del-premio-nobel-de-medicina_20181001/
2018 Interview in Radio Pauta, program “La Invención del Futuro” (1 October 2018)
Url: http://www.pauta.cl/programas/la-invencion-del-futuro/alvaro-lladser-sobre-el-descubrimiento-clave-del-cancer
2018 Article in online newspaper El Mostrador (8 October 2018)
Url: http://www.elmostrador.cl/cultura/2018/10/08/la-investigacion-chilena-contra-el-cancer-para-fortalecer-el-sistema-inmunologico/
2018 Article in national newspaper LUN (31 March 2018)
Url: http://www.lun.com/Pages/NewsDetail.aspx?dt=2018-03-31&NewsID=397338&BodyID=0&PaginaId=2

Alvaro Lladser

Progress In Vaccination Against Cancer PIVAC-10

Reino Unido, 2010

Best poster, “DAI (ZBP1/DLM-1) as a genetic adjuvant for DNA vaccines that promotes antitumor CTL immunity”
Alvaro Lladser

DNA Vaccines 2011: Building on Clinical Progress and Exploring New Targets

Estados Unidos, 2011

Outstanding summary, “Harnessing DNA-sensing pathways of innate immunity for DNA vaccines against cancer”
Alvaro Lladser

Cell Biology society of Chile

Chile, 2013

Best Undergratuate poster (Felipe Gálvez Cancino). "NFkB activation during intradermal DNA vaccination controls migration of skin-derived dendritic cells and induction of tumor-protective CTL responses".
Alvaro Lladser

Annual Meeting of the Association for Cancer Immunotherapy (CIMT): "Next waves in cancer immunotherapy"

Alemania, 2014

Awarded Best Poster category "Improving Immunity" (Nicole Rojas Colonelli). "DNA vaccination in combination with an RNAi-based genetic adjuvant silencing STAT3 promotes migration of mature dermal dendritic cells and antitumor T cell responses against B16 melanoma".
Alvaro Lladser

Cell Biology Society of Chile

Chile, 2015

Best Postraduate poster (Ernesto López)
Alvaro Lladser

Chilean Immunology Association

Chile, 2017

Best doctoral poster (Felipe Gálvez)


CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity Pedro Briceño, Elizabeth Rivas-Yañez, Mariana V. Rosemblatt, Brian Parra-Tello, Paula Farías, Leonardo Vargas, Valeska Simon, César Cárdenas, Alvaro Lladser, Flavio Salazar-Onfray, Alvaro A. Elorza, Mario Rosemblatt, María Rosa Bono and Daniela Sauma Article WOS FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1 alpha S-Nitrosylation and Transcriptional Activity in Hypoxia Sanhueza, Carlos; Bennett, Jimena Castillo; Valenzuela-Valderrama, Manuel; Contreras, Pamela; Lobos-Gonzalez, Lorena; Campos, America; Wehinger, Sergio; LLadser, Alvaro; Kiessling, Rolf; Leyton, Lisette; Quest, Andrew F. G. Article ISI CANCERS (2020)
Loss of Caveolin-1 Is Associated with a Decrease in Beta Cell Death in Mice on a High Fat Diet Lillo Urzua, Paloma; Nunez Murillo, Olinda; Castro-Sepulveda, Mauricio; Torres-Quintana, Maria A.; Lladser Caldera, Alvaro; Quest, Andrew F. G.; Espinoza Robles, Carolina; Llanos Vidal, Paola; Wehinger, Sergio Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Transcriptional and Functional Analysis of CD1c(+) Human Dendritic Cells Identifies a CD163(+) Subset Priming CD8(+)CD103(+) T Cells Bourdely, Pierre; Anselmi, Giorgio; Vaivode, Kristine; Ramos, Rodrigo Nalio; Missolo-Koussou, Yoann; Hidalgo, Sofia; Tosselo, Jimena; Nunez, Nicolas; Richer, Wilfrid; Vincent-Salomon, Anne; Saxena, Alka; Wood, Kristie; LLadser, Alvaro; Piaggio, Eliane; Helft, Julie; Guermonprez, Pierre Article ISI IMMUNITY (2020)
Analysis of Tissue-Resident Immune Cells from Mouse Skin and Lungs by Flow Cytometry. Galvez-Cancino, Felipe; Lopez, Ernesto; Lladser, Alvaro Article Methods in molecular biology (Clifton, N.J.) (2019)
Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation Arce, Maximiliano; Pinto, Mauricio P.; Galleguillos, Macarena; Munoz, Catalina; Lange, Soledad; RAMIREZ, CAROLINA; Erices, Rafaela; Gonzalez, Pamela; Velasquez, Ethel; Tempio, Fabian; Lopez, Mercedes N.; Salazar-Onfray, Flavio; Cautivo, Kelly; Kalergis, Alexis M; Cruz, Sebastian; LLadser, Alvaro; Lobos-Gonzalez, Lorena; Valenzuela, Guillermo; Olivares, Nixa; Saez, Claudia; Koning, Tania; Sanchez, Fabiola A.; Fuenzalida, Patricia; Godoy, Alejandro; Contreras Orellana, Pamela; Leyton, Lisette; Lugano, Roberta; Dimberg, Anna; Quest, Andrew F. G.; Owen, Gareth, I Article ISI SCOPUS CANCERS (2019)
Immunotherapeutic Potential of Mollusk Hemocyanins in Combination with Human Vaccine Adjuvants in Murine Models of Oral Cancer Roman, JJM; Del Campo, M; Villar, J; Paolini, F; Curzio, G; Venuti, A; Jara, L; Ferreira, J; Murgas, P; Lladser, A; Manubens, A; Becker, MI Article ISI SCOPUS JOURNAL OF IMMUNOLOGY RESEARCH (2019)
Immunotherapeutic Potential of Mollusk Hemocyanins in Combination with Human Vaccine Adjuvants in Murine Models of Oral Cancer Roman, JJM; Del Campo, M; Villar, J; Paolini, F; Curzio, G; Venuti, A; Jara, L; Ferreira, J; Murgas, P; Lladser, A; Manubens, A; Becker, MI Article Journal of immunology research (2019)
Small Extracellular Vesicles Released from Ovarian Cancer Spheroids in Response to Cisplatin Promote the Pro-Tumorigenic Activity of Mesenchymal Stem Cells Vera, Nelly; Acuña-Gallardo, Stephanie; Grünenwald, Felipe; Caceres-Verschae, Albano; Realini, Ornella; Acuña, Rodrigo; LLadser, Alvaro; Illanes, Sebastián E.; Varas-Godoy, Manuel Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
STAT3 Activation in Combination with NF-KappaB Inhibition Induces Tolerogenic Dendritic Cells with High Therapeutic Potential to Attenuate Collagen-Induced Arthritis Prado C.; Ugalde V.; GonzÃ¡lez H.; Figueroa A.; LÃ³pez E.; Lladser A.; Pacheco R. Article ISI SCOPUS JOURNAL OF IMMUNOLOGY RESEARCH (2019)
Tissue-resident memory CD8(+) T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells Menares, Evelyn; Galvez-Cancino, Felipe; Caceres-Morgado, Pablo; Ghorani, Ehsan; Lopez, Ernesto; Diaz, Ximena; Saavedra-Almarza, Juan; Figueroae, Diego A.; Roa, Eduardo; Quezada, Sergio A.; LLadser, Alvaro Article ISI SCOPUS NATURE COMMUNICATIONS (2019)
Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells Menares E, Gálvez-Cancino F, Cáceres-Morgado P, Ghorani E, López E, Díaz X, Saavedra-Almarza J, Figueroa DA, Roa E, Quezada SA, Lladser A Article NATURE COMMUNICATIONS (2019)
A filamentous bacteriophage targeted to carcinoembryonic antigen induces tumor regression in mouse models of colorectal cancer Murgas, paola; Bustamante, Nicolás; Araya, Nicole; Cruz-Gómez, Sebastián; Durán, Eduardo; Gaete, Diana; Oyarce, César; López, Ernesto; Herrada, Andrés Alonso; Ferreira, Nicolás; Pieringer, Hans; LLadser, Alvaro Article ISI SCOPUS CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)
Cripto-1 Plasmid DNA Vaccination Targets Metastasis and Cancer Stem Cells in Murine Mammary Carcinoma Witt K.; Ligtenberg M.A.; Conti, L; Lanzardo S.; Ruiu R.; Wallmann T.; Tufvesson-Stiller H.; Chambers B.J.; Rolny C.; Lladser A.; Lundqvist A.; Cavallo, F; Kiessling R. Article ISI SCOPUS Cancer immunology research (2018)
Dopaminergic stimulation of Myeloid antigen-Presenting cells attenuates signal Transducer and activator of Transcription 3-activation Favouring the Development of experimental autoimmune encephalomyelitis Prado, Carolina; Gaiazzi, Michela; González, Hugo; Ugalde, Valentina; Figueroa, Alicia; Osorio-Barrios, Francisco J.; López, Ernesto; LLadser, Alvaro; Rasini, Emanuela; Marino, Franca; Zaffaroni, Mauro; Cosentino, Marco; Pacheco, Rodrigo Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
In Vitro-generated Tc17 cells Present a Memory Phenotype and serve as a reservoir of Tc1 cells In Vivo Flores-Santibáñez, Felipe; Cuadra, Bárbara; Fernández, Dominique; Rosemblatt, Mariana V.; Núñez, Sarah; Cruz, Pablo; Gálvez-Cancino, Felipe; Cárdenas, J. César; LLadser, Alvaro; Rosemblatt, Mario; Bono, María Rosa; Sauma, Daniela Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
In vivo knockdown of antisense non-coding mitochondrial RNAs by a lentiviral-encoded shRNA inhibits melanoma tumor growth and lung colonization Varas-Godoy, M; Lladser, A; Farfan, N; Villota, C; Villegas, J; Tapia, JC; Burzio, LO; Burzio, VA; Valenzuela, PDT Article ISI SCOPUS PIGMENT CELL & MELANOMA RESEARCH (2018)
IRE1 alpha Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8(+) T Cell Priming Medel B.; Costoya C.; Fernandez D.; Pereda C.; Lladser A.; Sauma D.; Pacheco R.; Iwawaki T.; Salazar-Onfray F.; Osorio F. Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)
Vaccination-induced skin-resident memory CD8(+) T cells mediate strong protection against cutaneous melanoma Galvez-Cancino, Felipe; Lopez, Ernesto; Menares, Evelyn; Diaz, Ximena; Flores, Camila; Caceres, Pablo; Hidalgo, Sofia; Chovar, Ornella; Alcantara-Hernandez, Marcela; Borgna, Vincenzo; Varas-Godoy, Manuel; Salazar-Onfray, Flavio; Idoyaga, Juliana; LLadser, Alvaro Article ISI SCOPUS ONCOIMMUNOLOGY (2018)
A short hairpin RNA-based adjuvant targeting NF-kappa B repressor I kappa B alpha promotes migration of dermal dendritic cells to draining lymph nodes and antitumor CTL responses induced by DNA vaccination Gálvez-Cancino, Felipe; Roco, Jonathan; Rojas-Colonelli, Nicole; Flores, Camila; Murgas, Paola; Cruz-Gómez, Sebastián; Oyarce, César; Varas-Godoy, Manuel; Sauma, Daniela; Lladser, Alvaro Article ISI SCOPUS VACCINE (2017)
Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8(+) T Cell Responses Oyarce, C; Cruz-Gomez, S; Galvez-Cancino, F; Vargas, P; Moreau, HD; Diaz-Valdivia, N; Diaz, J; Salazar-Onfray, FA; Pacheco, R; Lennon-Dumenil, AM; Quest, AFG; Lladser, A Article Frontiers in immunology (2017)
Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8+ T Cell Responses Oyarce C, Cruz-Gomez S, Galvez-Cancino F, Vargas P, Moreau HD, Diaz-Valdivia N, Diaz J, Salazar-Onfray FA, Pacheco R, Lennon-Dumenil AM, Quest AFG, Lladser A Article FRONTIERS IN IMMUNOLOGY (2017)
Inhibition of dopamine receptor D3 signaling in dendritic cells increases antigen cross-presentation to CD8(+) T-cells favoring anti-tumor immunity Figueroa, Claudio; Gálvez-Cancino, Felipe; Oyarce, Cesar; Contreras, Francisco; Prado, Carolina; Valeria, Catalina; Cruz, Sebastián; Lladser, Alvaro; Pacheco, Rodrigo Article ISI SCOPUS JOURNAL OF NEUROIMMUNOLOGY (2017)
Coexpressed Catalase Protects Chimeric Antigen Receptor-Redirected T Cells as well as Bystander Cells from Oxidative Stress-Induced Loss of Antitumor Activity Ligtenberg, MA; Mougiakakos D; Mukhopadhyay, M; Witt K.; Lladser, A; Chmielewski, M; Riet, T; Abken, H; Kiessling R. Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2016)
Cripto-1 vaccination elicits protective immunity against metastatic melanoma Ligtenberg, M. A.; Witt, K.; Galvez-Cancino, F.; Sette, A.; Lundqvist, A.; Lladser, A.; Kiessling, R. Article ISI SCOPUS ONCOIMMUNOLOGY (2016)
Dopamine receptor D3 signaling on CD4+ T cells favors Th1-and Th17-mediated immunity Contreras, F; Prado C; GONZALEZ, H; Franz D.; Osorio-Barrios, F; Osorio, F; Ugalde, V.; López E.; Elgueta, D; Figueroa, A; Lladser, A; Pacheco R. Article ISI SCOPUS Journal of Immunology (2016)
Purinergic Signaling as a Regulator of Th17 Cell Plasticity Fernández, Dominique; Flores-Santibáñez, Felipe; Neira, Jocelyn; Osorio-Barrios, Francisco; Tejón, Gabriela; Nuñez, Sarah; Hidalgo, Yessia; Fuenzalida, Maria Jose; Meza, Daniel; Ureta, Gonzalo; Lladser, Alvaro; Pacheco, Rodrigo; Acuña-Castillo, Claudio; Guixé, Victoria; Quintana, Francisco J.; Bono, Maria Rosa; Rosemblatt, Mario; Sauma, Daniela; Chamaillard, Mathias Article ISI PLOS ONE (2016)
E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells Lobos-Gonzalez, L; Aguilar, L; Díaz, J; Díaz N; Urra, H; Torres, VA; Silva, V.; Fitzpatrick, C; Lladser, A; Hoek KS; Leyton, L; Quest, AFG Article ISI SCOPUS Pigment Cell and Melanoma Research (2013)
NF-kappa B activation during intradermal DNA vaccination is essential for eliciting tumor protective antigen-specific CTL responses Ligtenberg, MA; Rojas-Colonelli, N; Kiessling R.; Lladser, A Article ISI SCOPUS Human Vaccines and Immunotherapeutics (2013)
Tumour cell lysate-loaded dendritic cell vaccine induces biochemical and memory immune response in castration-resistant prostate cancer patients Reyes, D; Salazar, L; Espinoza E.; Pereda, C; Castellón E.; Valdevenito, R; Huidobro C.; Becker, MI; Lladser, A; López MN; SALAZAR ONFRAY F Article ISI SCOPUS British Journal of Cancer (2013)
Harnessing DNA-induced immune responses for improving cancer vaccines Herrada AA, Rojas-Colonelli N, González-Figueroa P, Roco J, Oyarce C, Ligtenberg MA, Lladser A Article Human Vaccines & Immunotherapeutics (2012)
Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity Prado C; Contreras, F; GONZALEZ, H; Díaz P; Elgueta, D; Barrientos M.; Herrada A.A.; Lladser, A; Bernales S.; Pacheco R. Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2012)
DAI (DLM-1/ZBP1) as a Genetic Adjuvant for DNA Vaccines That Promotes Effective Antitumor CTL Immunity Lladser, A; Mougiakakos D; Tufvesson H; Ligtenberg M.A.; Kiessling R.; Ljungberg K.; Quest, A.F.G. Article ISI SCOPUS Molecular Therapy (2011)
Is survivin the potential Achilles’ heel of cancer?. Lladser A*, Sanhueza C, Kiessling R, Quest AF Article Advances in Cancer Research (2011)
Intradermal DNA electroporation induces survivin-specific CTLs, suppresses angiogenesis and confers protection against mouse melanoma Lladser, A; Ljungberg K.; Tufvesson H; Tazzari, M; Roos, AK; Quest, AFG; Kiessling R. Article ISI SCOPUS Cancer Immunology, Immunotherapy (2010)
Regulatory T cells in cancer Dimitrios Mougiakakos, Aniruddha Choudhury, Alvaro Lladser, Rolf Kiessling, and C. Christian Johansson Article Advances in Cancer Research (2010)
E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-Catenin-Tcf/Lef-dependent transcription Torres, VA; Tapia, JC; Rodriguez, DA; Lladser, A; Arredondo, C; Leyton, L; Quest, AFG Article ISI SCOPUS MOLECULAR AND CELLULAR BIOLOGY (2007)
Naked DNA immunization as an approach to target the generic tumor antigen survivin induces humoral and cellular immune responses in mice Lladser, A; Párraga M.; Quevedo, L.; Molina, MC; Silva, S; Ferreira A.; Billetta, R; Quest, AFG Article ISI SCOPUS IMMUNOBIOLOGY (2006)
Use of an acetaldehyde clamp" in the determination of low-K-M aldehyde dehydrogenase activity in H4-II-E-C3 rat hepatoma cells" Moncada, C; Fuentes N.; Lladser, A; Encina G.; Sapag, A; Karahanian, E; Israel, Y Article ISI SCOPUS ALCOHOL (2003)


Analysis of immune responses and tumor protection in C57/Bl6 mice immunized with altered CD8 survivin peptide ligands. de Coana, YP; Duru, AD; Lladser, A; Achour, A; Kiessling R. Abstract ISI CANCER RESEARCH (2013)
Caveolin-1 reduced HIF1 alpha transcriptional activity in hypoxic cancer cells via nitric oxide synthase inhibition Sanhueza C.; Avalos, Y; Silva P.; Diaz, MI; Lladser, A; Leyton, L; Quest, AF Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2013)
E-cadherin is a molecular switch for Caveolin-1 function in melanoma cells that synergizes in tumor suppression and blocks Caveolin-1-enhanced metastasis Lobos-Gonzalez, L; Aguilar, L; Díaz, J; Díaz N; Urra, H; Lladser, A; Hoek, K; Leyton, L; Quest, A Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2012)


Caveolin-1 promotes CCL21-dependent chemotactic migration of dendritic cells to lymph nodes Cruz, Sebastián; Oyarce, César; Vargas, Pablo; Gálvez-Cancino, Felipe; Díaz, Jorge; Diaz, Natalia; Lopez, Ernesto; Lennon-Duménil, Ana-María; Quest, Andrew F.G.; Lladser, Alvaro ConferencePoster (2016)
Cripto-1 is a potential novel target for renal cancer stem cells Hidalgo, Sofía; Borgna, Vincenzo; Araya, Mariela; Lopez, Ernesto; Cruz, Sebastián; Alarcón, Luis; Carrasco, Macarena; Lladser, Alvaro ConferencePoster (2016)
Reciprocal regulation between skin resident memory CD8+ T cells and CD103+ dermal dendritic cells Menares, Evelyn; Gálvez-Cancino, Felipe; Lopez, Ernesto; Hidalgo, Sofia; Lladser, Alvaro ConferencePoster (2016)
Skin-resident memory CD8+ T cells mediate protective immunity against cutaneous melanoma in mice Lopez, Ernesto; Gálvez-Cancino, Felipe; Flores, Camila; Menares, Evelyn; Cruz, Sebastián; Hidalgo, Sofía; Durán, Eduardo; Oyarce, César; Lladser, Alvaro ConferencePoster (2016)
Vaccination-induced skin-resident memory CD8+ T cells mediate rejection of cutaneous melanoma in mice Lopez, Ernesto; Gálvez-Cancino, Felipe; Flores, Camila; Menares, Evelyn; Cruz, Sebastián; Hidalgo, Sofía; Durán, Eduardo; Oyarce, César; Lladser, Alvaro ConferencePoster (2016)
Caveolin-1 is required for LPS-induced dendritic cell maturation Cruz, Sebastián; Oyarce, César; Gálvez-Cancino, Felipe; Díaz, J; Díaz, N; Quest, AF; Lladser, Alvaro ConferencePoster (2015)
Intradermal vaccination generates skin-resident memory CD8 T cells with enhanced effector properties Gálvez-Cancino, Felipe; Flores, C; Rojas-Colonelli, N; Gaete, D; Murgas, P; Lladser, Alvaro ConferencePoster (2015)
OX40 signaling confers resistance to lactic acid in T cells transduced with chimeric antigen receptors López, E; Durán, Eduardo; Torres, E; Murgas, P; Lladser, Alvaro ConferencePoster (2015)
Caveolin-1 is required for dendritic cell maturation and migration to peripheral lymph nodes Oyarce, C; Murgas, Paola; Bustamante, N; Gálvez-Cancino, F; Quest, A.F; Lladser, Alvaro ConferencePoster (2014)
Cripto-1 encoding DNA vaccine elicits tumor protective immune response in vivo Witt, K; Ligtenberg, MA; Tufvesson, H; Lladser, Alvaro; Kiessling, R ConferencePoster (2014)
DNA vaccination in combination with an RNAi-based genetic adjuvant silencing STAT3 promotes migration of mature dermal dendritic cells and antitumor T cell responses against B16 melanoma Rojas-Colonelli, N; Galvez-Cancino, F; Flores, C; Diaz-Ubilla, M; Murgas, P; Lladser, Alvaro ConferencePoster (2014)
RNAi-based silencing of STAT3 during intradermal DNA vaccination promotes antitumor T cell immunity Rojas-Colonelli, N; Galvez-Cancino, F; Flores, C; Ligtenberg, MA; Kiessling, R; Lladser, Alvaro ConferencePoster (2014)
DNA vaccination with an shRNA silencing STAT3 improves antitumor T cell responses in a mouse melanoma model Rojas-Colonelli, N; Gálvez, F; Murgas, P; Flores, C; Lladser, Alvaro ConferencePoster (2013)
NF-κB activation during DNA vaccination is essential for eliciting tumor protective antigen-specific CTL responses after intradermal DNA electroporation Ligtenberg, MA; Rojas-Colonelli, N; Kiessling, R; Lladser, Alvaro ConferencePoster (2013)
NFκB activation during intradermal DNA vaccination controls migration of skin-derived dendritic cells and induction of tumor-protective CTL responses Gálvez-Cancino, F; Rojas-Colonelli, N; Roco, J; Flores, C; Murgas, P; Lladser, Alvaro ConferencePoster (2013)
An shRNA-based adjuvant against IκBα promotes antitumor T cell responses mediated by DNA vaccines Roco, J; Herrada, A; Lladser, Alvaro ConferencePoster (2012)
Caveolin-1 and β-catenin levels are increased in LPS-stimulated dendritic cells Oyarce, C; Herrada, A; Bustamante, N; Quest, AF; Lladser, Alvaro ConferencePoster (2012)
Development of an RNAi-based genetic adjuvant silencing STAT3 for DNA vaccines against tumors Rojas-Colonelli, N; Herrada, A; Murgas, P; Varas, M; Lladser, Alvaro ConferencePoster (2012)
Optimizing the retroviral transduction of T cells with chimeric antigen receptors (CARs) against the carcinoembryonic antigen (CEA) for a potential antitumor immunotherapy González-Figueroa, P; Murgas, P; Lladser, Alvaro ConferencePoster (2012)
A lentivirus encoding RNAi targeting a non-coding mitochondrial RNA inhibits melanoma tumor growth and metastasis in a mouse model Varas, M; Lladser, Alvaro; Farfán, N; Valenzuela, PD; Burzio, LO ConferencePoster (2011)
Activating the β–catenin pathway modulates the phenotype of dendritic cells Oyarce, C; Herrada, A; Quest, AF; Lladser, Alvaro ConferencePoster (2011)
Characterizing the DNA-sensing signaling pathways of the innate immunity that mediate the induction of antitumor T cell immunity elicited by DNA vaccines: the role of NF-κB Roco, J; Ligtenberg, MA; Herrada, A; Kiessling, R; Lladser, Alvaro ConferencePoster (2011)
Developing an RNAi-based genetic adjuvant silencing STAT3 that counteracts tumor-associated tolerance Rojas-Colonelli, N; Roco, J; Herrada, A; Aravena, O; Varas, M; Lladser, Alvaro ConferencePoster (2011)


Caveolin-1 inhibits transcription by hypoxia inducible factor-1α in tumor cells Sanhueza, C; Lladser, Alvaro; Valenzuela, M; Núñez, S; Díaz, MI; Leyton, L; Quest, AF ConferenceProceedingWhole (2011)
Harnessing DNA-sensing pathways of innate immunity for DNA vaccines against cancer Lladser, Alvaro; Ligtenberg, MA; Mougiakakos, D; Tufvesson, H; Quest, AF; Ljungberg, K; Kiessling, R ConferenceProceedingWhole (2011)


Ingeniería genética de linfocitos T con receptores quiméricos para el desarrollo de inmunoterapias contra el cáncer Lladser, Alvaro Proyecto (2017)
UNVEILING THE ROLE OF RESIDENT MEMORY CD8 T CELLS IN ANTITUMOR IMMUNITY FONDECYT (1171703) Proyecto 2017-2020 Inv. Responsable
UNVEILING THE ROLE OF RESIDENT MEMORY CD8 T CELLS IN ANTITUMOR IMMUNITY Lladser, Alvaro Proyecto (2017)
INGENIERÍA GENÉTICA DE LINFOCITOS T CON RECEPTORES QUIMÉRICOS PARA EL DESARROLLO DE INMUNOTERAPIAS CONTRA EL CÁNCER FONDEF (ID16I10369) Proyecto 2016-2018 Director(a)
ROLE OF DOPAMINE RECEPTORS EXPRESSED ON CD4 T-CELLS AND ON DENDRITIC CELLS IN THE DEVELOPMENT OF AUTOIMMUNE RESPONSE AND IN CELLULAR MECHANISMS INVOLVED IN THE PHYSIOPATHOLOGY OF MULTIPLE SCLEROSIS FONDECYT (1130271) Proyecto 2013-2017 Coinvestigador(a)
Role of dopamine receptors expressed on CD4+ T-cells and on dendritic cells in the development of autoimmune response and in cellular mechanisms involved in the physiopathology of Multiple Sclerosis Pacheco, Rodrigo; Lladser, Alvaro Proyecto (2013)
DESARROLLO DE UNA INMUNOTERAPIA CONTRA CANCERES DEL APARATO DIGESTIVO BASADA EN BACTERIOFAGOS ESPECIFICOS PARA EL ANTIGENO CEA FONDECYT (3130764) Proyecto 2012-2015 Inv. Patrocinante
DESARROLLO DE UNA INMUNOTERAPIA CONTRA CÁNCERES DEL APARATO DIGESTIVO BASADA EN BACTERIÓFAGOS ESPECÍFICOS PARA EL ANTÍGENO CEA Murgas, Paola; Lladser, Alvaro Proyecto (2012)
Desarrollo de una inmunoterapia para cánceres del aparato digestivo basada en bacteriófagos específicos para el antígeno CEA CORFO-Innova (12IDL2-13348) Proyecto 2012-2015 Inv. Principal
Utilización de vectores lentivirales para el desarrollo de una terapia génica para la artritis CORFO-Innova (12IDL2-16030) Proyecto 2012-2015 Coinvestigador(a)
DEVELOPMENT OF RNAI-BASED GENETIC ADJUVANTS MODULATING MASTER REGULATORS OF IMMUNITY AND TOLERANCE TO ENHANCE THE POTENCY OF GENE VACCINES AGAINST CANCER FONDECYT (11110525) Proyecto 2011-2014 Inv. Responsable
Development of RNAi-based genetic adjuvants modulating master regulators of immunity and tolerance to enhance the potency of gene vaccines against cancer Lladser, Alvaro Proyecto (2011)
Fortalecimiento de la investigación, el entrenamiento de capital humano avanzado y el emprendimiento en la Fundación Ciencia para la Vida Lladser, Alvaro Proyecto (2011)
FUNDACIÓN CIENCIA PARA LA VIDA FONDAP (PFB-16) Proyecto 2010-2017 Inv. Principal
Fundación Ciencia y Vida Lladser, Alvaro Proyecto (0)


The function and dysfunction of memory CD8(+) T cells in tumor immunity Reading, JL; Galvez-Cancino, F; Swanton, C; Lladser, A; Peggs, KS; Quezada, SA Review ISI SCOPUS IMMUNOLOGICAL REVIEWS (2018)
Harnessing DNA-induced immune responses for improving cancer vaccines Herrada, AA; Rojas-Colonelli, N; Gonzáles-Figueroa P; Roco J; Oyarce, C; Ligtenberg, MA; Lladser, A Review ISI SCOPUS Human Vaccines and Immunotherapeutics (2012)
Is Survivin the Potential Achilles' Heel of Cancer? Lladser, A; Sanhueza C.; Kiessling R.; Quest, AFG Review ISI SCOPUS Advances in Cancer Research (2011)
Regulatory T Cells in Cancer Mougiakakos D; Choudhury A.; Lladser, A; Kiessling R.; Johansson, CC Review ISI ADVANCES IN CANCER RESEARCH, VOL 107 (2010)

Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

HUGO GONZALEZ

Associate Professor

Fundación Ciencia y Vida

Santiago, Chile

Cesar Oyarce Diaz

Posdtoc

MMB

UMCG

Groningen, Holanda

MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

Valentina Ugalde

Asistente de Investigación

Laboratorio de Neuroinmunología

Fundación Ciencia & Vida

Santiago, Chile

Lorena Lobos

Principal Investigator-Associate Proffesor

Facultad of Medicine - Clinic Alemana

Universidad Del Desarrollo

santiago, Chile

Paola Murgas

Profesor Investigador Asistente

Facultad de Ciencias

Universidad Austral de Chile

Valdivia , Chile

Francisco Contreras

Investigador en área de Investigación y Desarrollo de productos biológicos

Centrovet Ltda.

Santiago, Chile

Flavio Salazar

Profesor titular

Instituto de ciencias biomédicas

Universidad de Chile

SANTIAGO, Chile

LORENA AGUILAR

Assistant Professor

Animal Pathology

Faculty of Veterinary Medicine and Livestock Sciences, University of Chile

Santiago, Chile

Hery Urra

Staff scientist

INSTITUTO DE NEUROCIENCIA BIOMEDICA (BNI)

Santiago, Chile

Vicente Torres

Associate Professor

Institute for Research in Dental Sciences

FACULTAD DE ODONTOLOGÍA - UNIVERSIDAD DE CHILE

Santiago, Chile

María Becker

Scientific Director, President

Research and Development

FUNDACIÓN CIENCIA Y TECNOLOGÍA PARA EL DESARROLLLO

Santiago, Chile

Mercedes López

Profesora Asociada

Instituto de Ciencias Biomédicas

Universidad de chile

Santiago, Chile

Fabiola Osorio

Associate Professor

Programa Disciplinario de Inmunologia

Universidad de Chile

Santiago, Chile

Sofía Hidalgo

Investigadora Postdoctoral

Departamento de Biología

Universidad de Chile

Santiago, Chile

Sergio Wehinger

Académico Asociado

Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

Evelyn Menares

investigador postdoctoral

programa disciplinario de inmunología

Universidad de Chile

santiago, Chile

Sarah Nuñez

Académico Investigador

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

Maria Bono

Profesor titular

Biologia

UNIVERSIDAD DE CHILE

Santiago, Chile

Mario Rosemblatt

Executive Director

Fundacion Ciencia & Vida

Santiago, Chile

Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Julio Tapia

Profesor Asociado

Oncologia Basico Clinica

Universidad de Chile

Santiago, Chile

Augusto Manubens

Director

Tecnical Support

BIOSONDA S.A.

Santiago, Chile

Ximena Diaz

Asistente de investigación

Fundación ciencia y vida

Santiago, Chile

Mauricio Pinto

Investigador

STORM SPA

Santiago, Chile

Christopher Fitzpatrick

Postoctoral Researcher

Non coding RNAs

Fundación Ciencia y Vida

Santiago, Chile

Vincenzo Borgna

Investigador

Inmuno-Oncología

FUNDACION CIENCIA VIDA

Santiago, Chile

Jorge Ferreira

Director

Clinic and Molecular Farmacology

UNIVERSIDAD DE CHILE , FACULTAD DE MEDICINA, ICBM

Santiago, Chile

Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

Victoria Guixé

Titular Profesor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Jocelyn Neira

Especialista Profesional

Universidad Andrés Bello

Santiago, Chile

Claudio Figueroa

Profesor Asistente

Ciencias Biológicas y Quimicas

Universidad San Sebastian

Santiago, Chile

Sebastián Illanes

professor, Director of Reproductive Biology Laboratory

Medicine

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

Fabian Tempio

Asistente de Investigación

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Gabriela Tejon

Investigador Postdoctoral

Biología

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Lilian Jara

Titular Professor

Human Molecular Genetic

UNIVERSIDAD DE CHILE / FACULTAD DE MEDICINA

Santiago, Chile

Eduardo Roa

Lab manager/Asistente de investigación

Inmunoncología

Fundación Cienca para la Vida

Santiago, Chile

Gonzalo Ureta

Investigador post doctoral

Fundación Ciencia y Vida

Santiago, Chile

Nicole Farfán

Asistente de investigación

instituto de ciencias biomedicas

Universidad del Desarrollo

Santiago, Chile

Lorena Salazar

Academico

Instituto Cs Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

MARIA MOLINA

Director

Instituto de Ciencias Biomédicas

Universidad de Chile

INDEPENDENCIA, Chile

Fabiola Sánchez

Associate Profesor

Immunology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

JULIO TAPIA

Full Professor

Program of Cellular and Molecular Biology

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Patricia Diaz

Academic

University of Connecticut Health Center

Farmington, CT, Estados Unidos

Rodrigo Acuña

Profesor Asistente Investigador

Medicina

Universidad del Desarrollo

Santiago, Chile

Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Felipe Grunenwald

Postdoctoral Researcher

CIIB

Universidad de Los Andes

santiago, Chile

Claudia Saez

Associate Professor

Hematology-Oncology

Pontificia Universidad Católica de Chile

Santiago, Chile

Andres Herrada

Principal Investigator

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Talca, Chile

ARTURO FERREIRA

FULL PROFESSOR, CHAIR IMMUNOLOGY DISCIPLINARY PROGRAM

IMMUNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

Pablo Díaz

Professional/Scientific advisor

Scientific Affairs

Instituto de Salud Públida de Chile

santiago, Chile

Raul Valdevenito

Chair

UNIVERSIDAD DE CHILE, HOSPITAL CLINICO UNIVERSIDAD DE CHILE

Santiago, Chile

Enrique Castellón

Profesor Titular. Director

Oncología Básico-Clínica

UNIVERSIDAD DE CHILE

Santiago, Chile

Lorena Salazar

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Lampa, Chile

Ethel Velásquez

Directora (t) Centro de Investigaciones Nucleares para Aplicaciones en Salud y Biomedicina

Comisión Chilena de Energía Nuclear

Santiago, Chile

Sebastian Bernales

Founder

Merken Biotech

Santiago, Chile

Mario Párraga

JEFE DE LABORATORIO

ANATOMÍA

UNIVERSIDAD DE VALPARAÍSO

Reñaca, Chile

Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

Eduardo Karahanian

Académico Investigador

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

Gonzalo Encina

Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

Alvaro Fernando Lladser Caldera

Líneas de Investigación

Educación

Biochemist, UNIVERSIDAD DE CHILE. Chile, 2001

Biochemistry, UNIVERSIDAD DE CHILE. Chile, 1999

Inmunología, UNIVERSIDAD DE CHILE. Chile, 2007

Experiencia Académica

Principal Investigator, Laboratory of Immunoncology Full Time

Postdoctoral Investigator Full Time

Experiencia Profesional

Undergraduate student Full Time

Research Assistant Full Time

Graduate student Full Time

Postdoctoral investigator Full Time

Principal Investigator Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Alvaro Lladser

Alvaro Lladser

Alvaro Lladser

Alvaro Lladser

Alvaro Lladser

Alvaro Lladser

Article (39)

Abstract (3)

ConferencePoster (23)

ConferenceProceedingWhole (2)

Proyecto (15)

UNVEILING THE ROLE OF RESIDENT MEMORY CD8 T CELLS IN ANTITUMOR IMMUNITY

INGENIERÍA GENÉTICA DE LINFOCITOS T CON RECEPTORES QUIMÉRICOS PARA EL DESARROLLO DE INMUNOTERAPIAS CONTRA EL CÁNCER

ROLE OF DOPAMINE RECEPTORS EXPRESSED ON CD4 T-CELLS AND ON DENDRITIC CELLS IN THE DEVELOPMENT OF AUTOIMMUNE RESPONSE AND IN CELLULAR MECHANISMS INVOLVED IN THE PHYSIOPATHOLOGY OF MULTIPLE SCLEROSIS

DESARROLLO DE UNA INMUNOTERAPIA CONTRA CANCERES DEL APARATO DIGESTIVO BASADA EN BACTERIOFAGOS ESPECIFICOS PARA EL ANTIGENO CEA

Desarrollo de una inmunoterapia para cánceres del aparato digestivo basada en bacteriófagos específicos para el antígeno CEA

Utilización de vectores lentivirales para el desarrollo de una terapia génica para la artritis

DEVELOPMENT OF RNAI-BASED GENETIC ADJUVANTS MODULATING MASTER REGULATORS OF IMMUNITY AND TOLERANCE TO ENHANCE THE POTENCY OF GENE VACCINES AGAINST CANCER

FUNDACIÓN CIENCIA PARA LA VIDA

Review (4)