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Sonja Milena Buvinic Radic

Associate Professor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


• Molecular bases of muscle-bone cross-talk. • Signaling mediated by extracellular nucleotides. • Muscle Physiology / Bone Physiology in health and disease • Molecular bases of masticatory muscle plasticity. • Temporomandibular pathophysiology.

Educación

  •  PhD in Biological Sciences with a concentration in Molecular and Cellular Biology , PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Bachelor degree in Biochemist, UNIVERSIDAD DE CHILE. Chile, 2001
  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 2000

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Medicine

    Santiago, Chile

    2010 - 2011

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Santiago, Chile

    2011 - 2019

  •   Associate Professor Full Time

    UNIVERSIDAD DE CHILE

    Faculty of Dentistry

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   Trainee student Full Time

    Lab of Red Tide and Bromatology, Health Service of Magallanes

    Punta Arenas, Chile

    1999 - 1999

  •   Trainee student Full Time

    Molecular Pharmacology Lab, INSPIRE Pharmaceuticals Inc

    Durham, Estados Unidos

    2003 - 2003

  •   Postdoc trainee Full Time

    Lab of Muscle Cellular Physiology, Faculty of Medicine, Universidad de Chile

    Santiago, Chile

    2007 - 2009

  •   Assistant Professor Full Time

    Faculty of Dentistry, Universidad de Chile

    Santiago, Chile

    2011 - 2019

  •   Assistant Professor Full Time

    Faculty of Medicine, Universidad de Chile

    Santiago, Chile

    2010 - 2011

  •   Deputy Director Part Time

    Institute for Research in Dental Sciences, Faculty of Dentistry, Universidad de Chile

    Santiago, Chile

    2014 - 2016

  •   Study Group Member Part Time

    CONICYT / Study Group Medicine G1

    Santiago, Chile

    2016 - A la fecha

  •   Associate Professor Full Time

    Faculty of Dentistry, Universidad de Chile

    Chile

    2019 - A la fecha

  •   International collaborator (Internship) Full Time

    Indiana Center for Musculoskeletal Health, Indiana University School of Medicine

    Indianapolis, Estados Unidos

    2019 - 2019

  •   Director Part Time

    Sociedad Chilena de Ciencias Fisiológicas

    Chile

    2019 - A la fecha

  •   Member of the academic committee, Master Program in Dental Sciences Part Time

    Faculty of Dentistry, Universidad de Chile

    Chile

    2019 - 2021

Formación de Capital Humano


Undergraduate thesis direction:

- Francisco Cid. Thesis to Obtain the Professional Title of Dental Surgeon, Universidad de Chile. "Efecto temprano de la parálisis del músculo masetero de ratón por Toxina Botulínica tipo A en la microestructura y macroestructura ósea del cóndilo mandibular: Análisis tridimensional con microtomografía computarizada" In progress
- Angélica Araya. Thesis to Obtain the Professional Title of Dental Surgeon, Universidad de Chile. "Inducción de apoptosis en células tipo osteoblasto Saos-2 expuestas a adhesivos dentales universales" Approved in 2019
- Nathalie Vicencio. Thesis to Obtain the Professional Title of Dental Surgeon, Universidad de Chile. "Caracterización de la expresión de receptores purinérgicos de tipo P2Y en músculo masetero de ratón" Approved in 2018.
- Fernán Gómez Valenzuela. Thesis to Obtain the Professional Title of Dental Surgeon, Universidad de Chile. "Función del ATP extracelular en la Diferenciación de Células RAW264.7 a Osteoclastos Maduros". Approved in 2017.
- Giomar Intriago Lúa. Thesis to Obtain the Professional Title of Medical Technologist, Universidad de Chile. "Caracterización de complejos multiproteicos e Influencia de Nifedipino sobre la Apoptosis en Fibras Musculares de Ratones mdx". Approved in 2015.

MD thesis direction:
- Walter Vásquez Águila. Thesis to obtain the Master Degree in Biological Sciences, Universidad de Chile. "Efectos de la inyección de toxina botulínica tipo A sobre la vía de señalización del ATP extracelular en músculo masetero de ratón" Approved in 2020
- Óscar Quinteros. Thesis to obtain the Master Degree in Biological Sciences, Universidad de Chile. "Acción de Rosiglitazona, agonista PPARg, sobre la expresión de ABCA1: Efecto sobre los niveles de colesterol de membrana plasmática y la sensibilidad a la insulina en el músculo esquelético de ratones obesos" Approved in 2018.
- Rodrigo Fernández Verdejo. Thesis to obtain the Master Degree in Biological Sciences, Universidad de Chile. "Efectos de la Actividad Física Voluntaria sobre la Expresión Génica de Interleuquina-6 Inducida por ATP en Fibras Musculares de Ratón". Approved in 2011.
- Manuel Arias Calderón. Thesis to obtain the Master Degree in Biochemistry. "Caracterización Molecular de un Complejo Multiproteico Involucrado en el Acoplamiento Excitación-Transcripción en el Músculo Esquelético". Approved in 2014.

PhD thesis direction:

- Esteban Quezada Cornejo. Thesis to obtain the PhD Degree in Biomedical Sciences. Universidad de Chile. "Papel de la apoptosis en la atrofia de músculo masetero de ratón inducida por toxina botulínica tipo A" In progress
- Manuel Arias Calderón. Thesis to obtain the PhD Degree in Biomedical Sciences. Universidad de Chile. “Rol del estímulo eléctrico, a través de la señalización mediada por ATP extracelular, en la regulación de la expresión y secreción del factor de crecimiento de fibroblastos-21 en músculo esquelético” Approved in 2019
- Carolina Rojas Beato. Thesis to obtain the PhD Degree in Biomedical Sciences. Universidad de Chile. "Efecto de la Actividad Masticatoria Sobre la Produccion y Liberación de Il-1? e Il-6 a Traves de la Señalizacion por ATP Extracelular en Fibras de Músculo Masetero de Ratón" Approved in 2019
- Julián Balanta Melo. Thesis to obtain the PhD Degree in Dental Sciences. Universidad de Chile. "Osteopenia mandibular post-parálisis del músculo masetero inducida por toxina botulínica: Apoptosis de osteocitos cómo mecanismo de acción" Approved in 2019
- Camilo Morales Jiménez. Thesis to obtain the PhD Degree in Biomedical Sciences. Universidad de Chile. "ATP liberado por osteoblastos y osteoclastos activa la síntesis proteica del músculo esquelético a través de la vía PI3K/Akt/mTOR". Approved in 2018


Difusión y Transferencia


Organizer "Ciclo de seminarios 2020 / Fisiología Celular del Sistema Musculoesquelético: De los conceptos básicos al conocimiento avanzado actual" (Lecture Series 2020 Cellular physiology of the musculoskeletal system
/ From basic concepts to current advanced knowledge)
International Lecture Series, Online. 20 conferences. 15 international lecturers (Chile-Colombia-EEUU-Australia)
August 2020- January 2021
1500 attendees from 16 countries
https://seminarios-musculo-hueso-latam.cl/log-in/
http://odontologia.uchile.cl/noticias/172714/finalizo-exitoso-ciclo-de-seminarios-fisiologia-celular-


Premios y Distinciones

  •   Best Poster Award / 62nd Annual Meeting of the Society of General Physiologists

    Society of General Physiology

    Estados Unidos, 2008

    Dr. Sonja Buvinic Radic was the winner of the “Best Poster Award” with the poster “Calcium transients evoked by electrical stimulation are in part dependent on ATP release and P2X/P2Y receptor activation in skeletal muscle cells” at the 62nd Annual Meeting of the Society of General Physiologists. This meeting was held at the Marine Biological Laboratory, in Woods Hole, MA in 2008.

  •   ASCB Predoctoral Travel Award

    American Association for Cell Biology

    Estados Unidos, 2005

    Travel award for attending to the 45th annual meeting of the ASCB. San Francisco, USA.

  •   Travel award 62nd Annual Meeting of the Society of General Physiologists

    Society of General Physiology

    Chile, 2008

    Travel award for attending to the 62nd Annual Meeting of the Society of General Physiologists. Woods Hole, MA, USA.

  •   Best Poster Award / Annual Meeting of the Chilean Society for Cell Biology

    Hyclone

    Chile, 2005

    Hyclone Award to the best poster presented at the 2005 Annual Meeting of the Chilean Society for Cell Biology

  •   Biochemistry Best Graduate Student Award

    UNIVERSIDAD DE CHILE

    Chile, 2001

    Best Graduate Student Award, Biochemistry, Universidad de Chile

  •   Best Nitric Oxide Investigation Award

    Comité Iberoamericano de Investigadores del Oxido Nítrico.

    España, 2001

    Best Nitric Oxide Investigation Award. Comité Iberoamericano de Investigadores del Oxido Nítrico. VI International Meeting About Nitric Oxide Actions. Sevilla, Spain.

  •   Award to the best application to Biochemistry

    Universidad de Chile

    Chile, 1995

    Universidad de Chile award to the best application to Biochemistry 1995


 

Article (20)

Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions
Pannexin-1 and CaV1.1 show reciprocal interaction during excitation-contraction and excitation-transcription coupling in skeletal muscle
In vitro and in vivo studies using non-traditional bisphosphonates
Biological, mechanical and adhesive properties of universal adhesives containing zinc and copper nanoparticles
Mandibular Bone Loss after Masticatory Muscles Intervention with Botulinum Toxin=> An Approach from Basic Research to Clinical Findings
Masseter muscle atrophy impairs bone quality of the mandibular condyle but not the alveolar process early after induction
Early molecular response and microanatomical changes in the masseter muscle and mandibular head after botulinum toxin intervention in adult mice
Mandibular bone loss: a hidden side effect of botulinum toxin type A injection in masticatory muscles.
Three-dimensional assessment of enamel and dentine in mouse molar teeth during masseter muscle hypofunction
Characterization of a multiprotein complex involved in excitation-transcription coupling of skeletal muscle
ROS Production via P2Y(1)-PKC-NOX2 Is Triggered by Extracellular ATP after Electrical Stimulation of Skeletal Muscle Cells
Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca2+ signals and an IL-6 autocrine loop
Exercise Sensitizes Skeletal Muscle to Extracellular ATP for IL-6 Expression in Mice
Cav1.1 controls frequency-dependent events regulating adult skeletal muscle plasticity
Electrical Stimuli Are Anti-Apoptotic in Skeletal Muscle via Extracellular ATP. Alteration of This Signal in Mdx Mice Is a Likely Cause of Dystrophy
ATP Released by Electrical Stimuli Elicits Calcium Transients and Gene Expression in Skeletal Muscle
Nucleotide P2Y(1) receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells
P2Y(1) and P2Y(2) receptor distribution varies along the human placental vascular tree: role of nucleotides in vascular tone regulation
P2Y(1) and P2Y(2) receptors are coupled to the NO/cGMP pathway to vasodilate the rat arterial mesenteric bed
Basal tonic release of nitric oxide coupled to cGMP production regulates the vascular reactivity of the mesenteric bed

Abstract (17)

ATP signaling complex is altered in muscular dystrophy and was partly recovered after nifedipine treatment
Extracellular ATP as a relevant mediator between skeletal muscle depolarizaition and interleukin-6 expression: from cell culture to whole animal adaptations
Atp-Induced Membrane Depolarization Relates to Skeletal Muscle Fibers Plasticity
PI3-kinase is involved in plasticity of adult myofibers acting as a nodal step that originates divergent pathways for gene expression
Unveiling Molecular Constituents of a Multiprotein Complex Involved in Excitation-Transcription Coupling in Skeletal Muscle
A molecular mechanism for frequency dependent skeletal muscle fiber plasticity
ATP released by electrical stimulation of myotubes triggers IL6 expression and increases STAT3 activity
Molecular characterization of a multiprotein complex that links membrane depolarization with gene expression in skeletal muscle
Muscle Plasticity Is Regulated by a Process Involving ATP Release and Inositol Trisphosphate Production in Skeletal Myofibers
ATP release and autocrine signalling following gentle pipetting of HeLa cell media
TOWARDS A MOLECULAR MECHANISM FOR CALCIUM-DEPENDENT EXCITATION-TRANSCRIPTION COUPLING IN SKELETAL MUSCLE
Calcium transients evoked by electrical stimulation are in part dependent on ATP release and P2X/P2Y receptor activation in skeletal muscle cells
P2Y(1) and P2X(1) nucleotide receptors are distributed differently along the human placenta vessels
P2Y(1) nucleotide receptors regulate epithelial proliferation by trans modulation of the epidermal growth factor receptor
Basolateral regionalization and caveolin-1 mediated association with lipid rafts of the purine P2Y1 receptor
Pharmacological modulation of the L-arginine cascade in an arterial bed.
Release of endothelial nitric oxide by purinergic mechanisms in the rat mesentery

Proyecto (32)

Molecular determinants involved in musculoskeletal impairment after botulinum toxin type A intervention in the masticatory system
The NLRP3 Inflammasome in skeletal muscle=> a novel link between cholesterol accumulation and the defective insulin-mediated glucose transport in insulin resistance
Integrative Network for the study of musculoskeletal system in health and disease (INMuSS)
Nueva terapia farmacológica para el tratamiento de sarcopenia y distrofias musculares. Prueba de concepto.
Polycystin2-Beclin-1: a novel protein complex in autophagy regulation
Polycystin2-Beclin-1=> a novel protein complex in autophagy regulation
Nueva terapia farmacológica para el tratamiento de sarcopenia y distrofias musculares. Prueba de concepto
Desarrollo de una plataforma de microtomografía computarizada (microCT) para el análisis de animales y especímenes experimentales con el propósito de fortalecer la investigación avanzada en ciencias odontológicas.
Unveiling molecular basis for muscle remodeling and muscle-bone crosstalk at the masticatory apparatus=> extracellular ATP as a signaling molecule.
Unveiling molecular basis for muscle remodeling and muscle-bone crosstalk at the masticatory apparatus: extracellular ATP as a signaling molecule.
Adquisicion de una Ultracentrífuga con 4 rotores
Microscopio Electrónico de Barrido (SEM) con microanálisis EDX y equipos auxiliares
Plataforma de Microscopía Confocal para el uso en Investigaciones Biomedicas Avanzadas
Señalización por estrés metabólico en cáncer, enfermedades cardiovasculares y diabetes
Señalización por estrés metabólico en cáncer, enfermedades cardiovasculares y diabetes
A new role for dystrophin in excitation-transcription coupling in skeletal muscle
A new role for dystrophin in excitation-transcription coupling in skeletal muscle
Microscopio de epifluorescencia para promover estudios interdisciplinarios con enfoques de biología celular en la Facultad de Odontología de la Universidad de Chile
Microscopio de epifluorescencia para promover estudios interdisciplinarios con enfoques de biología celular en la Facultad de Odontología de la Universidad de Chile
Renovación Académica para el Desarrollo de la Medicina Molecular
Renovación Académica para el Desarrollo de la Medicina Molecular
Role of dystrophin in a macromolecular complex that
Role of dystrophin in a macromolecular complex that mediates excitation-transcription coupling in skeletal muscle
Unveiling a multiprotein complex involved in excitation-transcription coupling in skeletal muscle
Unveiling a multiprotein complex involved in excitation-transcription coupling in skeletal muscle
Centro FONDAP de Estudios Moleculares de la Célula
Conversacion Cruzada Entre el Receptor de Dihidropiridina y Receptores Acoplados a Proteina G Durante la Actividad del Musculo Esqueletico
Proyecto Postdoctorado=> Conversacion Cruzada Entre el Receptor de Dihidropiridina y Receptores Acoplados a Proteina G Durante la Actividad del Musculo Esqueletico
Participación del receptor P2Y1 para nucleótidos en la proliferación celular; comunicación cruzada con receptores para factores de crecimiento y regulación por compartimentalización subcelular
Participación del receptor P2Y1 para nucleótidos en la proliferación celular; comunicación cruzada con receptores para factores de crecimiento y regulación por compartimentalización subcelular
Centro FONDAP de Regulación Celular y Patología
Co-transmisión neuronal=> estudio en neuronas simpáticas perivasculares

Review (1)

ATP Signaling in Skeletal Muscle: From Fiber Plasticity to Regulation of Metabolism
48
Sonja Buvinic

Associate Professor

Institute for Research in Dental Sciences

Universidad de Chile

Santiago, Chile

19
Enrique Jaimovich

Full Professor

ICBM

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

14
Mariana Casas

Assistant Professor

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

5
Gonzalo Jorquera

Profesor Auxiliar

Instituto de Fisiología

Universidad de Valparaíso

Valparaíso, Chile

4
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

3
Denisse Valladares

Assistant Professor

Universidad de O'Higgins

Rancagua, Chile

2
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

1
ISAAC GARCÍA

Profesor Adjunto

Instituto de Neurociencias

Universidad de Valparaiso

Valparaiso, Chile

1
María Toro

Profesora Asistente

Instituto de Investigación en Ciencias Odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jorge Cancino

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

1
Alexis Diaz

PhD stundent

Fisiología

universidad de Chile

Santiago, Chile

1
Eduardo Fernandez

Profesor Asociado

UNIVERSIDAD DE CHILE

santiago, Chile

1
Mario Bustamante

Docente

Universidad Mayor de Chile

Santiago, Chile

1
JOSE GALGANI

ASSOCIATE PROFESSOR

NUTRITION, DIABETES AND METABOLISM; AND UDA-CIENCIAS DE LA SALUD, NUTRICION Y DIETETICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Berta Espinosa

Full Professor

Tecnología Médica

Universidad de Chile

Santiago, Chile

1
Mario Gutiérrez

Profesor Asistente

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

1
JAVIER MARTÍN

Director Departamento

Odontología Restauradora

Universidad de Chile

Santiago, Chile

1
Cristian Campos

Entrenamiento Post Doctorado

Fisiología

Universidad de Chile

Santiago, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Francisco Jaque

Post-Doctoral Researcher

INSTITUTE NEUROMYOGÈNE CNRS UMR 5310 - INSERM U1217

LYON, Francia

1
Walter Vásquez

Estudiante de doctorado

Centro interdisciplinario de neurociencias de Valparaíso

Universidad de Valparaíso

Valparaíso, Chile

1
Kornelius Kupczik

Profesor Titular

Antropología

Universidad de Chile

Santiago de Chile, Chile